Ptprd

Summary

Gene Symbol: Ptprd
Description: protein tyrosine phosphatase, receptor type, D
Alias: 1110002J03Rik, 3000002J10Rik, B230219D21Rik, R-PTP-delta, receptor-type tyrosine-protein phosphatase delta
Species: mouse

Top Publications

  1. ncbi RPTP delta and the novel protein tyrosine phosphatase RPTP psi are expressed in restricted regions of the developing central nervous system
    L Sommer
    Howard Hughes Medical Institute, Division of Biology, California Institute of Technology, Pasadena 91125, USA
    Dev Dyn 208:48-61. 1997
  2. doi Interleukin-1 receptor accessory protein organizes neuronal synaptogenesis as a cell adhesion molecule
    Tomoyuki Yoshida
    Department of Molecular Neurobiology and Pharmacology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Neurosci 32:2588-600. 2012
  3. doi IL-1 receptor accessory protein-like 1 associated with mental retardation and autism mediates synapse formation by trans-synaptic interaction with protein tyrosine phosphatase δ
    Tomoyuki Yoshida
    Department of Molecular Neurobiology and Pharmacology, Graduate School of Medicine, University of Tokyo, Tokyo 113 0033, Japan
    J Neurosci 31:13485-99. 2011
  4. ncbi Role of the different isoforms of cyclooxygenase and nitric oxide synthase during gastric ulcer healing in cyclooxygenase-1 and -2 knockout mice
    Adrian Schmassmann
    Department of Clinical Research, University of Berne, Switzerland
    Am J Physiol Gastrointest Liver Physiol 290:G747-56. 2006
  5. ncbi Mammalian motoneuron axon targeting requires receptor protein tyrosine phosphatases sigma and delta
    Noriko Uetani
    McGill Cancer Centre, Department of Biochemistry, McGill University, Montreal, Quebec, H3G 1Y6, Canada
    J Neurosci 26:5872-80. 2006
  6. pmc Quantitative traits for the tail suspension test: automation, optimization, and BXD RI mapping
    Heena V Lad
    Social, Genetic and Developmental Psychiatry Centre PO82, Institute of Psychiatry, King s College London, London, SE5 8AF, United Kingdom
    Mamm Genome 18:482-91. 2007
  7. pmc Mutational inactivation of PTPRD in glioblastoma multiforme and malignant melanoma
    David A Solomon
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University School of Medicine, Washington, District of Columbia 20057, USA
    Cancer Res 68:10300-6. 2008
  8. pmc Maturation of ureter-bladder connection in mice is controlled by LAR family receptor protein tyrosine phosphatases
    Noriko Uetani
    Goodman Cancer Centre, Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    J Clin Invest 119:924-35. 2009
  9. pmc Protein tyrosine phosphatases expression during development of mouse superior colliculus
    Jacqueline Reinhard
    Department of Cell Morphology and Molecular Neurobiology, Faculty of Biology, Ruhr University Bochum, Universitaetsstr 150, 44780, Bochum, Germany
    Exp Brain Res 199:279-97. 2009
  10. doi Differential gene expression in migrating cortical interneurons during mouse forebrain development
    Clare Faux
    Department of Cell and Developmental Biology, University College London, London WC1E 6BT, United Kingdom
    J Comp Neurol 518:1232-48. 2010

Scientific Experts

  • A Schmassmann
  • Heena V Lad
  • Robert Karisch
  • Tomoyuki Yoshida
  • Noriko Uetani
  • Yoichiro Iwakura
  • Misato Yasumura
  • Takeshi Uemura
  • Sung Jin Lee
  • Masayoshi Mishina
  • Clare Faux
  • Jacqueline Reinhard
  • David A Solomon
  • Michel L Tremblay
  • Melanie J Chagnon
  • Rosa Gonzalez-Quevedo
  • Christoph Fehr
  • K Mizuno
  • Tomoko Shiroshima
  • Xigui Chen
  • Moonjin Ra
  • Ryo Taguchi
  • Sonja Rakic
  • John G Parnavelas
  • N Uetani
  • William Andrews
  • Yuchio Yanagawa
  • Kunihiko Obata
  • Andreas Faissner
  • Andrea Horvat-Bröcker
  • Wiljan Hendriks
  • Piotr Knyazev
  • Sebastian Illes
  • Angelika Zaremba
  • Kristen Bertozzi
  • Axel Ullrich
  • Maxime Bouchard
  • Walter Jean
  • Timothy Ryken
  • Zita Sibenaller
  • Jung Sik Kim
  • Darell Bigner
  • Steven A Rosenberg
  • Julia C Cronin
  • Hai Yan
  • Todd Waldman
  • R Tuttle
  • Yardena Samuels
  • Habtom Ressom
  • H Yakura
  • M J Wallace
  • R Q Schaapveld
  • Timothy E Kennedy
  • Anthony E Oro
  • Lily Horng
  • Marina Shoffer
  • L Sommer
  • B Wieringa
  • Renee L Shirley
  • Kari J Buck
  • John C Crabbe
  • John K Belknap
  • K Huang
  • K Mikoshiba
  • W Hendriks
  • K Kawano
  • M Asano
  • Y Iwakura
  • J W Celler
  • K Kato
  • H Ogura
  • A J Symes
  • D D O'Leary
  • Y Nakagawa
  • J E Johnson
  • J Batt
  • W J Hendriks
  • J T Schepens
  • D Bächner
  • D Rotin
  • J Attema
  • C Fladd
  • P H Jap
  • D J Anderson
  • T Katagiri
  • K Hasegawa
  • M Rao
  • M Ogimoto
  • Y Kaneko
  • P E Love

Detail Information

Publications24

  1. ncbi RPTP delta and the novel protein tyrosine phosphatase RPTP psi are expressed in restricted regions of the developing central nervous system
    L Sommer
    Howard Hughes Medical Institute, Division of Biology, California Institute of Technology, Pasadena 91125, USA
    Dev Dyn 208:48-61. 1997
    ..5, the reciprocal expression patterns of RPTP delta and RPTP psi are consistent with a sequential function, RPTP psi exerting its activity in undifferentiated progenitor cells and RPTP delta functioning during neuronal differentiation...
  2. doi Interleukin-1 receptor accessory protein organizes neuronal synaptogenesis as a cell adhesion molecule
    Tomoyuki Yoshida
    Department of Molecular Neurobiology and Pharmacology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Neurosci 32:2588-600. 2012
    ..Thus, IL-1RAcP represents an interesting molecular link between immune systems and synapse formation in the brain...
  3. doi IL-1 receptor accessory protein-like 1 associated with mental retardation and autism mediates synapse formation by trans-synaptic interaction with protein tyrosine phosphatase δ
    Tomoyuki Yoshida
    Department of Molecular Neurobiology and Pharmacology, Graduate School of Medicine, University of Tokyo, Tokyo 113 0033, Japan
    J Neurosci 31:13485-99. 2011
    ..Our findings raise an intriguing possibility that the impairment of synapse formation may underlie certain forms of MR and autism as a common pathogenic pathway shared by these mental disorders...
  4. ncbi Role of the different isoforms of cyclooxygenase and nitric oxide synthase during gastric ulcer healing in cyclooxygenase-1 and -2 knockout mice
    Adrian Schmassmann
    Department of Clinical Research, University of Berne, Switzerland
    Am J Physiol Gastrointest Liver Physiol 290:G747-56. 2006
    ..As counterregulatory mechanisms, mRNA of COX and NOS isoforms were increased during healing in COX-impaired mice...
  5. ncbi Mammalian motoneuron axon targeting requires receptor protein tyrosine phosphatases sigma and delta
    Noriko Uetani
    McGill Cancer Centre, Department of Biochemistry, McGill University, Montreal, Quebec, H3G 1Y6, Canada
    J Neurosci 26:5872-80. 2006
    ....
  6. pmc Quantitative traits for the tail suspension test: automation, optimization, and BXD RI mapping
    Heena V Lad
    Social, Genetic and Developmental Psychiatry Centre PO82, Institute of Psychiatry, King s College London, London, SE5 8AF, United Kingdom
    Mamm Genome 18:482-91. 2007
    ..A second trial of the test has greater duration of immobility and a completely different genetic profile. Frequency of mobility is also an independent phenotype, with a distal chromosome 1 locus...
  7. pmc Mutational inactivation of PTPRD in glioblastoma multiforme and malignant melanoma
    David A Solomon
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University School of Medicine, Washington, District of Columbia 20057, USA
    Cancer Res 68:10300-6. 2008
    ..screen for copy number changes in glioblastoma multiforme (GBM), we detected a high frequency of deletions of the PTPRD gene, which encodes a receptor protein tyrosine phosphatase at chromosome 9p23-24.1...
  8. pmc Maturation of ureter-bladder connection in mice is controlled by LAR family receptor protein tyrosine phosphatases
    Noriko Uetani
    Goodman Cancer Centre, Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    J Clin Invest 119:924-35. 2009
    ..Together, these results suggest that ureter positioning is controlled by the opposing actions of Ret and LAR family phosphatases regulating apoptosis-mediated tissue morphogenesis...
  9. pmc Protein tyrosine phosphatases expression during development of mouse superior colliculus
    Jacqueline Reinhard
    Department of Cell Morphology and Molecular Neurobiology, Faculty of Biology, Ruhr University Bochum, Universitaetsstr 150, 44780, Bochum, Germany
    Exp Brain Res 199:279-97. 2009
    ....
  10. doi Differential gene expression in migrating cortical interneurons during mouse forebrain development
    Clare Faux
    Department of Cell and Developmental Biology, University College London, London WC1E 6BT, United Kingdom
    J Comp Neurol 518:1232-48. 2010
    ..These data therefore provide a framework for future studies aimed at elucidating the complexities of interneuron migration and, in turn, may reveal important genes that are related to the development of specific neurological disorders...
  11. pmc Global proteomic assessment of the classical protein-tyrosine phosphatome and "Redoxome"
    Robert Karisch
    Department of Medical Biophysics, University of Toronto, Toronto M5G 2M9, ON, Canada
    Cell 146:826-40. 2011
    ....
  12. pmc Receptor tyrosine phosphatase-dependent cytoskeletal remodeling by the hedgehog-responsive gene MIM/BEG4
    Rosa Gonzalez-Quevedo
    Program in Epithelial Biology, School of Medicine, Stanford University, Stanford, CA 94305, USA
    J Cell Biol 168:453-63. 2005
    ..MIM-dependent cytoskeletal changes can be inhibited using a soluble RPTPdelta-D2 domain. Our data suggest that the hedgehog-responsive gene MIM cooperates with RPTP to induce cytoskeletal changes...
  13. ncbi Congenic mapping of alcohol and pentobarbital withdrawal liability loci to a <1 centimorgan interval of murine chromosome 4: identification of Mpdz as a candidate gene
    Christoph Fehr
    Portland Alcohol Research Center and Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon 97201, USA
    J Neurosci 22:3730-8. 2002
    ..These analyses, and evidence using interval-specific congenic lines, show that alcohol withdrawal severity is genetically correlated with MPDZ status, indicating that MPDZ variants may influence alcohol withdrawal liability...
  14. pmc Impaired learning with enhanced hippocampal long-term potentiation in PTPdelta-deficient mice
    N Uetani
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Minato ku, Tokyo 108 8639, Japan
    EMBO J 19:2775-85. 2000
    ..To our knowledge, this is the first report of a specific PTP involved in the regulation of synaptic plasticity or in the processes regulating learning and memory...
  15. ncbi mRNA expression of two transmembrane protein tyrosine phosphatases is modulated by growth factors and growth arrest in 3T3 fibroblasts
    J W Celler
    Max Planck Society, Faculty of Medicine, Friedrich Schiller University, Jena, Germany
    Biochem Biophys Res Commun 209:614-21. 1995
    ..In cells whose growth was arrested by contact inhibition at high cell density or by serum starvation at low cell density mRPTP-sigma mRNA level increased. The possible implications of these mRNA expression patterns are discussed...
  16. pmc A novel receptor-type protein tyrosine phosphatase with a single catalytic domain is specifically expressed in mouse brain
    W Hendriks
    Department of Cell Biology and Histology, University of Nijmegen, The Netherlands
    Biochem J 305:499-504. 1995
    ..This suggests a role for PTP-SL in cell-cell signalling processes in the brain...
  17. ncbi Developmental regulation of gene expression for the MPTP delta isoforms in the central nervous system and the immune system
    K Mizuno
    Tokyo Metropolitan Institute for Neuroscience, Japan
    FEBS Lett 355:223-8. 1994
    ..An in situ hybridization study showed that MPTP delta mRNA is diffusely expressed throughout the spleen, but its expression in the thymus is restricted to the medullary region...
  18. ncbi Identification of protein tyrosine phosphatases expressed in murine male germ cells
    Y Kaneko
    Department of Clinical Molecular Biology, Kyoto University Faculty of Medicine, Japan
    Biochem Biophys Res Commun 197:625-31. 1993
    ....
  19. pmc MPTP delta, a putative murine homolog of HPTP delta, is expressed in specialized regions of the brain and in the B-cell lineage
    K Mizuno
    Tokyo Metropolitan Institute for Neuroscience, Japan
    Mol Cell Biol 13:5513-23. 1993
    ..Finally, the MPTP delta locus was tightly linked to the brown (b) locus on mouse chromosome 4...
  20. ncbi Cloning and characterization of PTP-K1, a novel nonreceptor protein tyrosine phosphatase highly expressed in bone marrow
    K Huang
    Laboratory of Mammalian Genes and Development, NICHD, NIH, Bethesda, Maryland 20892, USA
    Oncogene 13:1567-73. 1996
    ..The high level expression of PTP-K1 mRNA in bone marrow suggests that PTP-K1 may be involved in signal transduction in growth and differentiation of hematopoietic cells...
  21. pmc The second catalytic domain of protein tyrosine phosphatase delta (PTP delta) binds to and inhibits the first catalytic domain of PTP sigma
    M J Wallace
    Division of Respiratory Research, The Hospital for Sick Children, Toronto, Ontario, Canada
    Mol Cell Biol 18:2608-16. 1998
    ....
  22. ncbi Developmental expression of the cell adhesion molecule-like protein tyrosine phosphatases LAR, RPTPdelta and RPTPsigma in the mouse
    R Q Schaapveld
    Department of Cell Biology and Histology, Institute of Cellular Signalling, University of Nijmegen, Adelbertusplein 1, 6525 EK, Nijmegen, The Netherlands
    Mech Dev 77:59-62. 1998
    ..RPTP sigma is found in (neuro)ectodermal, neural crest-derived systems and in mesoderm-derived tissues. The expression pattern of RPTP sigma largely parallels that of RPTP sigma, in concordance with their proposed evolutionary history..
  23. ncbi Defects in thalamocortical axon pathfinding correlate with altered cell domains in Mash-1-deficient mice
    R Tuttle
    Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, CA 92037, USA
    Development 126:1903-16. 1999
    ..In addition, these findings support the hypothesis that ventral telencephalic neurons and their axons guide TCAs through ventral thalamus and into ventral telencephalon...
  24. ncbi Differences in nuclear signaling by leukemia inhibitory factor and interferon-gamma: the role of STAT proteins in regulating vasoactive intestinal peptide gene expression
    A J Symes
    Department of Neurology, Massachusetts General Hospital, Boston 02114, USA
    J Neurochem 65:1926-33. 1995
    ..These findings show that regions within the CyRE distinct from the STAT site are important to the LIF-dependent regulation of VIP gene expression and enable the CyRE to respond in a cell-specific and cytokine-specific manner...