Gene Symbol: Ptpn6
Description: protein tyrosine phosphatase, non-receptor type 6
Alias: 70Z-SHP, Hcph, PTPTY-42, Ptp1C, SH-PTP1, SHP-1, hcp, tyrosine-protein phosphatase non-receptor type 6, SH2 phosphatase 1, hematopoietic cell protein-tyrosine phosphatase, motheaten, protein-tyrosine phosphatase 1C
Species: mouse
Products:     Ptpn6

Top Publications

  1. Berg K, Carlberg K, Rohrschneider L, Siminovitch K, Stanley E. The major SHP-1-binding, tyrosine-phosphorylated protein in macrophages is a member of the KIR/LIR family and an SHP-1 substrate. Oncogene. 1998;17:2535-41 pubmed
    ..a substrate of SHP-1 in vitro and is hyperphosphorylated on tyrosine in SHP-1 deficient macrophages from viable-motheaten mice...
  2. Pao L, Lam K, Henderson J, Kutok J, Alimzhanov M, Nitschke L, et al. B cell-specific deletion of protein-tyrosine phosphatase Shp1 promotes B-1a cell development and causes systemic autoimmunity. Immunity. 2007;27:35-48 pubmed
    Spontaneous loss-of-function mutations in the protein-tyrosine phosphatase Shp1 cause the motheaten phenotype, characterized by widespread inflammation and autoimmunity...
  3. Carter J, Neel B, Lorenz U. The tyrosine phosphatase SHP-1 influences thymocyte selection by setting TCR signaling thresholds. Int Immunol. 1999;11:1999-2014 pubmed
    ..10 TCR transgene onto the motheaten background, which lacks SHP-1 expression...
  4. Cornall R, Cyster J, Hibbs M, Dunn A, Otipoby K, Clark E, et al. Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection. Immunity. 1998;8:497-508 pubmed
    ..The biochemical basis of this complex trait involves a pathway requiring Lyn to phosphorylate CD22 and recruit SHP-1 to the CD22/BCR complex. ..
  5. Dubois M, Bergeron S, Kim H, Dombrowski L, Perreault M, Fournès B, et al. The SHP-1 protein tyrosine phosphatase negatively modulates glucose homeostasis. Nat Med. 2006;12:549-56 pubmed
    ..Here we show that Ptpn6(me-v/me-v) (also known as viable motheaten) mice bearing a functionally deficient SHP-1 protein are markedly glucose tolerant and insulin sensitive as ..
  6. Cho S, Oh S, Zhu Z, Lee J, Lane A. Spontaneous eosinophilic nasal inflammation in a genetically-mutant mouse: comparative study with an allergic inflammation model. PLoS ONE. 2012;7:e35114 pubmed publisher
    ..These mice lack the enzyme SHP-1 that down-regulates the IL-4R?/stat6 signaling pathway. We compared nasal inflammation and inflammatory mediators in SHP-1 deficient mice (mev) and an ovalbumin-induced nasal allergy model...
  7. Oriente F, Iovino S, Cabaro S, Cassese A, Longobardi E, Miele C, et al. Prep1 controls insulin glucoregulatory function in liver by transcriptional targeting of SHP1 tyrosine phosphatase. Diabetes. 2011;60:138-47 pubmed publisher
    ..SHP1, a known silencer of insulin signal, is a transcriptional target of Prep1. In liver, transcriptional activation of SHP1 gene by Prep1 attenuates insulin signal transduction and reduces glucose storage. ..
  8. Shultz L, Schweitzer P, Rajan T, Yi T, Ihle J, Matthews R, et al. Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene. Cell. 1993;73:1445-54 pubmed
    Mice homozygous for the recessive allelic mutation motheaten (me) or viable motheaten (mev) on chromosome 6 develop severe defects in hematopoiesis...
  9. Massa P, Wu C, Fecenko Tacka K. Dysmyelination and reduced myelin basic protein gene expression by oligodendrocytes of SHP-1-deficient mice. J Neurosci Res. 2004;77:15-25 pubmed the protein tyrosine phosphatase SHP-1 and that myelin formation was decreased in SHP-1-deficient motheaten mice compared to that in normal littermates...

More Information


  1. Kaneko T, Saito Y, Kotani T, Okazawa H, Iwamura H, Sato Hashimoto M, et al. Dendritic cell-specific ablation of the protein tyrosine phosphatase Shp1 promotes Th1 cell differentiation and induces autoimmunity. J Immunol. 2012;188:5397-407 pubmed publisher
    ..Moreover, aged mutant mice developed glomerulonephritis and interstitial pneumonitis together with increased serum concentrations of autoantibodies. Shp1 is thus a key regulator of DC functions that protects against autoimmunity. ..
  2. Zhang L, Oh S, Wu X, Oh M, Wu F, Schroeder J, et al. SHP-1 deficient mast cells are hyperresponsive to stimulation and critical in initiating allergic inflammation in the lung. J Immunol. 2010;184:1180-90 pubmed publisher
    ..survival, and functional responses to stimulation using bone marrow-derived mast cells from viable motheaten (mev) mice...
  3. Nyström A, Shaik Z, Gullberg D, Krieg T, Eckes B, Zent R, et al. Role of tyrosine phosphatase SHP-1 in the mechanism of endorepellin angiostatic activity. Blood. 2009;114:4897-906 pubmed publisher
    ..Our results show that SHP-1 is an essential mediator of endorepellin activity and discover a novel functional interaction between the integrin alpha2 subunit and SHP-1. ..
  4. Shultz L, Green M. Motheaten, an immunodeficient mutant of the mouse. II. Depressed immune competence and elevated serum immunoglobulins. J Immunol. 1976;116:936-43 pubmed
    Mice homozygous for the recessive mutation motheaten (me) are deficient in capacity for immune response but show an elevated level of serum immunoglobulins...
  5. Kozlowski M, Mlinaric Rascan I, Feng G, Shen R, Pawson T, Siminovitch K. Expression and catalytic activity of the tyrosine phosphatase PTP1C is severely impaired in motheaten and viable motheaten mice. J Exp Med. 1993;178:2157-63 pubmed
    ..containing a COOH-terminal catalytic and two NH2-terminal Src homology 2 (SH2) domains, have been identified in motheaten (me) and viable motheaten (mev) mice and are associated with severe hemopoietic dysregulation...
  6. Zhang J, Somani A, Yuen D, Yang Y, Love P, Siminovitch K. Involvement of the SHP-1 tyrosine phosphatase in regulation of T cell selection. J Immunol. 1999;163:3012-21 pubmed
    ..analysis of T cell development in H-Y TCR transgenic mice rendered SHP-1 deficient by introduction of the viable motheaten mutation or a dominant negative SHP-1-encoding transgene...
  7. Shultz L, Rajan T, Greiner D. Severe defects in immunity and hematopoiesis caused by SHP-1 protein-tyrosine-phosphatase deficiency. Trends Biotechnol. 1997;15:302-7 pubmed
    ..Mutations at the 'motheaten' locus result in severe immunological dysfunction due to disruption of the structural gene encoding Src-homology ..
  8. Wishcamper C, Coffin J, Lurie D. Lack of the protein tyrosine phosphatase SHP-1 results in decreased numbers of glia within the motheaten (me/me) mouse brain. J Comp Neurol. 2001;441:118-33 pubmed
    Mice that are homozygous for the autosomal recessive motheaten allele (me/me) lack the protein tyrosine phosphatase SHP-1...
  9. Horvat A, Schwaiger F, Hager G, Brocker F, Streif R, Knyazev P, et al. A novel role for protein tyrosine phosphatase shp1 in controlling glial activation in the normal and injured nervous system. J Neurosci. 2001;21:865-74 pubmed
    ..These results emphasize that SHP1 as a part of different signaling pathways plays an important role in the global regulation of astrocytic and microglial activation in the normal and injured CNS...
  10. Ward J. Pulmonary pathology of the motheaten mouse. Vet Pathol. 1978;15:170-8 pubmed
    Mice, homozygous for the motheaten gene, developed an unusual pneumonia that was the cause of natural death of mice by 7 weeks of age...
  11. Khaled A, Butfiloski E, Sobel E, Schiffenbauer J. Functional consequences of the SHP-1 defect in motheaten viable mice: role of NF-kappa B. Cell Immunol. 1998;185:49-58 pubmed
    ..of the src-homology domain-1 protein (SHP-1) defect, we examined cytokine production and NF-kappa B activity in motheaten viable (Mev) mice...
  12. Kamata T, Yamashita M, Kimura M, Murata K, Inami M, Shimizu C, et al. src homology 2 domain-containing tyrosine phosphatase SHP-1 controls the development of allergic airway inflammation. J Clin Invest. 2003;111:109-19 pubmed
    ..and in the development of Th2-dependent allergic airway inflammation by using a natural SHP-1 mutant, the motheaten mouse...
  13. Roach T, Slater S, White L, Zhang X, Majerus P, Brown E, et al. The protein tyrosine phosphatase SHP-1 regulates integrin-mediated adhesion of macrophages. Curr Biol. 1998;8:1035-8 pubmed
    ..The viable motheaten (Hcphme-v) mutant mice (mev) suffer from progressive inflammation due to a deficiency of SHP-1 enzyme activity [..
  14. Scribner C, Hansen C, Klinman D, Steinberg A. The interaction of the xid and me genes. J Immunol. 1987;138:3611-7 pubmed
    The murine "motheaten" (me) mutation has been bred onto the NFS background and combined with the X-linked immunodeficiency (xid) mutation to investigate the effect of the xid-induced B cell maturational block on the widespread ..
  15. Nakamura M, Niemi E, Fisher M, Shultz L, Seaman W, Ryan J. Mouse Ly-49A interrupts early signaling events in natural killer cell cytotoxicity and functionally associates with the SHP-1 tyrosine phosphatase. J Exp Med. 1997;185:673-84 pubmed
    ..tyrosine phosphatase SHP-1, and that Ly-49A function is impaired in NK cells from SHP-1 mutant viable motheaten mice and from SHP-1-deficient motheaten mice...
  16. Otipoby K, Draves K, Clark E. CD22 regulates B cell receptor-mediated signals via two domains that independently recruit Grb2 and SHP-1. J Biol Chem. 2001;276:44315-22 pubmed
    ..We propose that the cytoplasmic tail of CD22 contains two domains that regulate signal transduction pathways initiated by the BCR and B cell fate. ..
  17. Nesterovitch A, Szanto S, Gonda A, Bardos T, Kis Toth K, Adarichev V, et al. Spontaneous insertion of a b2 element in the ptpn6 gene drives a systemic autoinflammatory disease in mice resembling neutrophilic dermatosis in humans. Am J Pathol. 2011;178:1701-14 pubmed publisher
    ..onset was delayed, and the clinical phenotype was milder than the phenotypes of other Ptpn6-mutants described in motheaten (me, mev) mice; we designated this new genotype as Ptpn6(meB2/meB2) and the phenotype as meB2...
  18. Matthews R, Bowne D, Flores E, Thomas M. Characterization of hematopoietic intracellular protein tyrosine phosphatases: description of a phosphatase containing an SH2 domain and another enriched in proline-, glutamic acid-, serine-, and threonine-rich sequences. Mol Cell Biol. 1992;12:2396-405 pubmed
    ..These two additional members of the PTPase family accentuate the variety of PTPase structures and indicate the potential diversity of function for intracellular tyrosine phosphatases. ..
  19. Xiao W, Kashiwakura J, Hong H, Yasudo H, Ando T, Maeda Yamamoto M, et al. Phospholipase C-?3 regulates Fc?RI-mediated mast cell activation by recruiting the protein phosphatase SHP-1. Immunity. 2011;34:893-904 pubmed publisher
    ..Thus, we have defined a PLC-?3- and SHP-1-mediated signaling pathway for Fc?RI-mediated cytokine production. ..
  20. Park I, Shultz L, Letterio J, Gorham J. TGF-beta1 inhibits T-bet induction by IFN-gamma in murine CD4+ T cells through the protein tyrosine phosphatase Src homology region 2 domain-containing phosphatase-1. J Immunol. 2005;175:5666-74 pubmed
    ..Together, these data show that TGF-beta1 suppresses IFN-gamma signaling and transcriptional responses in CD4+ T cells through the PTP Shp-1. ..
  21. Lowin Kropf B, Kunz B, Beermann F, Held W. Impaired natural killing of MHC class I-deficient targets by NK cells expressing a catalytically inactive form of SHP-1. J Immunol. 2000;165:1314-21 pubmed
    ..A similar NK cell phenotype is observed in viable motheaten (mev) mice, which show reduced SHP-1 activity due to a mutation in the Shp-1 gene...
  22. Lorenz U, Bergemann A, Steinberg H, Flanagan J, Li X, Galli S, et al. Genetic analysis reveals cell type-specific regulation of receptor tyrosine kinase c-Kit by the protein tyrosine phosphatase SHP1. J Exp Med. 1996;184:1111-26 pubmed
    ..between the RTK c-Kit, encoded at the W locus, and the SH2-containing non-transmembrane PTP SHP1, encoded at the motheaten (me) locus (1)...
  23. Paulson R, Vesely S, Siminovitch K, Bernstein A. Signalling by the W/Kit receptor tyrosine kinase is negatively regulated in vivo by the protein tyrosine phosphatase Shp1. Nat Genet. 1996;13:309-15 pubmed
    ..murine Dominant white spotting (W) locus and the Shp1 protein tyrosine phosphatase, the product of the murine motheaten (me) gene...
  24. Xiao W, Ando T, Wang H, Kawakami Y, Kawakami T. Lyn- and PLC-beta3-dependent regulation of SHP-1 phosphorylation controls Stat5 activity and myelomonocytic leukemia-like disease. Blood. 2010;116:6003-13 pubmed publisher
    ..Therefore, we identify a novel Lyn/PLC-?3-mediated regulatory mechanism of SHP-1 and Stat5 activities. ..
  25. Xiao W, Hong H, Kawakami Y, Kato Y, Wu D, Yasudo H, et al. Tumor suppression by phospholipase C-beta3 via SHP-1-mediated dephosphorylation of Stat5. Cancer Cell. 2009;16:161-71 pubmed publisher
    ..The same mechanism for malignant transformation seems to be operative in other human lymphoid and myeloid malignancies. Thus, PLC-beta3 is likely a tumor suppressor...
  26. Jiao H, Berrada K, Yang W, Tabrizi M, Platanias L, Yi T. Direct association with and dephosphorylation of Jak2 kinase by the SH2-domain-containing protein tyrosine phosphatase SHP-1. Mol Cell Biol. 1996;16:6985-92 pubmed shown by its constitutive association with the Tyk2 kinase and the hyperphosphorylation of Jak kinases in the motheaten cells that lack functional SHP-1...
  27. Cho Y, Oh S, Zhu Z. Tyrosine phosphatase SHP-1 in oxidative stress and development of allergic airway inflammation. Am J Respir Cell Mol Biol. 2008;39:412-9 pubmed publisher
    ..the effect of oxidative stress on the development of allergic airway inflammation in heterozygous viable motheaten (mev/+) mice deficient of SHP-1. Wild-type (WT) and mev/+ mice were compared in this study...
  28. Croker B, Lawson B, Rutschmann S, Berger M, Eidenschenk C, Blasius A, et al. Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger. Proc Natl Acad Sci U S A. 2008;105:15028-33 pubmed publisher
    ..hypomorphic allele of Ptpn6, which encodes the tyrosine phosphatase SHP1, mutated in mice with the classical motheaten alleles me and me-v. Inflammation and autoimmunity caused by SHP1 deficiency are thus conditional...
  29. Oh S, Zheng T, Kim Y, Cohn L, Homer R, McKenzie A, et al. A critical role of SHP-1 in regulation of type 2 inflammation in the lung. Am J Respir Cell Mol Biol. 2009;40:568-74 pubmed publisher
    ..we sought to define the function of SHP-1 in the lung by characterizing the pulmonary inflammation of viable motheaten (mev) mice, and to investigate the molecular mechanisms involved...
  30. Zhao J, Brooks D, Lurie D. Lipopolysaccharide-activated SHP-1-deficient motheaten microglia release increased nitric oxide, TNF-alpha, and IL-1beta. Glia. 2006;53:304-12 pubmed
    ..abnormal microglial activation accompanied by increased neuronal loss within the auditory brainstem occurs in motheaten (me/me) mice deficient in the protein tyrosine phosphatase SHP-1...
  31. Yu W, Wang S, Keegan A, Williams M, Qu C. Abnormal Th1 cell differentiation and IFN-gamma production in T lymphocytes from motheaten viable mice mutant for Src homology 2 domain-containing protein tyrosine phosphatase-1. J Immunol. 2005;174:1013-9 pubmed
    ..Compared with the wild-type control, anti-CD3-activated mouse T lymphocytes carrying the motheaten viable mutation in the SHP-1 gene produced a significantly increased amount of IFN-gamma in the presence of IL-..
  32. Clark E, Shultz L, Pollack S. Mutations in mice that influence natural killer (NK) cell activity. Immunogenetics. 1981;12:601-13 pubmed
    ..loci that reduce NK-cell activity in the homozygous state were identified, including beige (bg), hairless (hr), motheaten (me), obese (ob), steel (Sl) and, to lesser extent, dominant spotting (W)...
  33. Abram C, Roberge G, Pao L, Neel B, Lowell C. Distinct roles for neutrophils and dendritic cells in inflammation and autoimmunity in motheaten mice. Immunity. 2013;38:489-501 pubmed publisher
    The motheaten mouse has long served as a paradigm for complex autoimmune and inflammatory disease. Null mutations in Ptpn6, which encodes the nonreceptor protein-tyrosine phosphatase Shp1, cause the motheaten phenotype...
  34. Kim C, Qu C, Hangoc G, Cooper S, Anzai N, Feng G, et al. Abnormal chemokine-induced responses of immature and mature hematopoietic cells from motheaten mice implicate the protein tyrosine phosphatase SHP-1 in chemokine responses. J Exp Med. 1999;190:681-90 pubmed
    ..activities induced by chemokines, we examined the role of SHP-1 in functions of chemokines using viable motheaten (me(v)/me(v)) mice that were deficient in SHP-1...
  35. Müller M, Klaile E, Vorontsova O, Singer B, Obrink B. Homophilic adhesion and CEACAM1-S regulate dimerization of CEACAM1-L and recruitment of SHP-2 and c-Src. J Cell Biol. 2009;187:569-81 pubmed publisher
    ..These data suggest that transmembrane signaling by CEACAM1 operates by alteration of the monomer/dimer equilibrium, which leads to changes in the SHP-2/c-Src-binding ratio. ..
  36. Stromnes I, Fowler C, Casamina C, Georgopolos C, McAfee M, Schmitt T, et al. Abrogation of SRC homology region 2 domain-containing phosphatase 1 in tumor-specific T cells improves efficacy of adoptive immunotherapy by enhancing the effector function and accumulation of short-lived effector T cells in vivo. J Immunol. 2012;189:1812-25 pubmed publisher
    ..These studies suggest that abrogating SHP-1 in effector T cells may improve the efficacy of tumor elimination by T cell therapy without affecting the ability of the effector cells to persist and provide a long-term response. ..
  37. Su X, Zhou T, Wang Z, Yang P, Jope R, Mountz J. Defective expression of hematopoietic cell protein tyrosine phosphatase (HCP) in lymphoid cells blocks Fas-mediated apoptosis. Immunity. 1995;2:353-62 pubmed
    ..The time course and level of dephosphorylation were correlated with increased hematopoietic cell protein tyrosine phosphatase (HCP) activity, but not with the activity of two other tyrosine phosphatases...
  38. Davidson W, Morse H, Sharrow S, Chused T. Phenotypic and functional effects of the motheaten gene on murine B and T lymphocytes. J Immunol. 1979;122:884-91 pubmed
    ..It remains to be determined what the basic deficiency in me/me mice is and whether it affects primarily B cells or all lymphoid cells. ..
  39. Wang L, Blasioli J, Plas D, Thomas M, Yokoyama W. Specificity of the SH2 domains of SHP-1 in the interaction with the immunoreceptor tyrosine-based inhibitory motif-bearing receptor gp49B. J Immunol. 1999;162:1318-23 pubmed
    ..Thus, gp49B signaling involves SHP-1, and this association is dependent on tyrosine phosphorylation of the gp49B ITIMs, and an intact SHP-1 carboxyl SH2 domain. ..
  40. Veillette A, Thibaudeau E, Latour S. High expression of inhibitory receptor SHPS-1 and its association with protein-tyrosine phosphatase SHP-1 in macrophages. J Biol Chem. 1998;273:22719-28 pubmed
    ..Taken together, these findings indicate that SHPS-1 is likely to play a significant role in macrophages, at least partially as a consequence of its capacity to recruit SHP-1. ..
  41. Tsui H, Siminovitch K, de Souza L, Tsui F. Motheaten and viable motheaten mice have mutations in the haematopoietic cell phosphatase gene. Nat Genet. 1993;4:124-9 pubmed
    Mice with the recessive motheaten (me) or the allelic viable motheaten (mev) mutations express a severe autoimmune and immunodeficiency syndrome...
  42. Umeda S, Beamer W, Takagi K, Naito M, Hayashi S, Yonemitsu H, et al. Deficiency of SHP-1 protein-tyrosine phosphatase activity results in heightened osteoclast function and decreased bone density. Am J Pathol. 1999;155:223-33 pubmed
    Mice homozygous for the motheaten (Hcphme) or viable motheaten (Hcphme-v) mutations are deficient in functional SHP-1 protein-tyrosine phosphatase and show severe defects in hematopoiesis...
  43. Green M, Shultz L. Motheaten, an immunodeficient mutant of the mouse. I. Genetics and pathology. J Hered. 1975;66:250-8 pubmed
    A new recessive mutation, motheaten (me), is on chromosome 6, 21.9 +/- 4.3 recombination units distal to white (Miwh)...
  44. Khalil A, Cambier J, Shlomchik M. B cell receptor signal transduction in the GC is short-circuited by high phosphatase activity. Science. 2012;336:1178-81 pubmed publisher
    ..Furthermore, SHP-1 was required for GC maintenance. Intriguingly, GC B cells in the cell-cycle G(2) period regained responsiveness to BCR stimulation. These data have implications for how higher-affinity B cells are selected in the GC...
  45. Johnson D, Pao L, Dhanji S, Murakami K, Ohashi P, Neel B. Shp1 regulates T cell homeostasis by limiting IL-4 signals. J Exp Med. 2013;210:1419-31 pubmed
    ..Mutations in Ptpn6, which encodes Shp1, result in widespread inflammation and premature death, known as the motheaten (me) phenotype...
  46. Jang M, Kim S, Lee K, Kim T, Moon K, Park C, et al. The tyrosine phosphatase, SHP-1, is involved in bronchial mucin production during oxidative stress. Biochem Biophys Res Commun. 2010;393:137-43 pubmed publisher
    ..Notably, mucin production was enhanced in the airway epithelia of mev/+ mice exposed to oxidative stress. Our results clearly indicate that SHP-1 plays an important role in airway mucin production through regulating oxidative stress. ..
  47. Fowler C, Pao L, Blattman J, Greenberg P. SHP-1 in T cells limits the production of CD8 effector cells without impacting the formation of long-lived central memory cells. J Immunol. 2010;185:3256-67 pubmed publisher
    ..Analysis of CD8 T cells from motheaten mice, which are globally deficient in SHP-1, proved problematic due to cell-extrinsic effects of SHP-1 ..
  48. Beamer C, Brooks D, Lurie D. Motheaten (me/me) mice deficient in SHP-1 are less susceptible to focal cerebral ischemia. J Neurosci Res. 2006;83:1220-30 pubmed
  49. Cyster J, Goodnow C. Protein tyrosine phosphatase 1C negatively regulates antigen receptor signaling in B lymphocytes and determines thresholds for negative selection. Immunity. 1995;2:13-24 pubmed
    b>Motheaten viable (mev) mice are deficient in the cytosolic protein tyrosine phosphatase, PTP1C, and exhibit severe B cell immunodeficiency and autoantibody production...
  50. Kruger J, Butler J, Cherapanov V, Dong Q, Ginzberg H, Govindarajan A, et al. Deficiency of Src homology 2-containing phosphatase 1 results in abnormalities in murine neutrophil function: studies in motheaten mice. J Immunol. 2000;165:5847-59 pubmed
    ..however, implied by the overexpansion and inappropriate activation of granulocyte populations in SHP-1-deficient motheaten (me/me) and motheaten viable (me(v)/me(v)) mice...
  51. Johnson K, LeRoy F, Borysiewicz L, Matthews R. TCR signaling thresholds regulating T cell development and activation are dependent upon SHP-1. J Immunol. 1999;162:3802-13 pubmed
    An examination of thymocytes and peripheral T cells from SHP-1-deficient motheaten mice possessing a transgenic MHC class I-restricted TCR has implicated SHP-1 in regulating TCR signaling thresholds at three checkpoints in T cell ..
  52. Huber M, Izzi L, Grondin P, Houde C, Kunath T, Veillette A, et al. The carboxyl-terminal region of biliary glycoprotein controls its tyrosine phosphorylation and association with protein-tyrosine phosphatases SHP-1 and SHP-2 in epithelial cells. J Biol Chem. 1999;274:335-44 pubmed
    ..Together, these results indicate that both SHP-1 and SHP-2 interact with the Bgp1 cytoplasmic domain via ITIM-like sequences. Furthermore, they reveal that the C-terminal amino acids of Bgp1 are critical for these interactions. ..
  53. Yi T, Cleveland J, Ihle J. Protein tyrosine phosphatase containing SH2 domains: characterization, preferential expression in hematopoietic cells, and localization to human chromosome 12p12-p13. Mol Cell Biol. 1992;12:836-46 pubmed
    ..Importantly, the human gene maps to chromosome 12 region p12-p13. This region is associated with rearrangements in approximately 10% of cases of acute lymphocytic leukemia in children. ..
  54. Pan H, Shively J. Carcinoembryonic antigen-related cell adhesion molecule-1 regulates granulopoiesis by inhibition of granulocyte colony-stimulating factor receptor. Immunity. 2010;33:620-31 pubmed publisher
    ..Thus, CEACAM1 acted as a coinhibitory receptor for G-CSFR regulating granulopoiesis and host innate immune response to bacterial infections. ..
  55. Carter J, Calabrese G, Naganuma M, Lorenz U. Deficiency of the Src homology region 2 domain-containing phosphatase 1 (SHP-1) causes enrichment of CD4+CD25+ regulatory T cells. J Immunol. 2005;174:6627-38 pubmed
    ..b>motheaten mice, lacking expression of SHP-1, showed a 2- to 3-fold increase in the percentage of CD4(+)CD25(+) T(reg) ..
  56. Shultz L, Coman D, Bailey C, Beamer W, Sidman C. "Viable motheaten," a new allele at the motheaten locus. I. Pathology. Am J Pathol. 1984;116:179-92 pubmed
    A new spontaneous autosomal recessive mutation has recently occurred at the motheaten (me) locus on Chromosome 6 in strain C57BL/6J mice...