Ptpn1

Summary

Gene Symbol: Ptpn1
Description: protein tyrosine phosphatase, non-receptor type 1
Alias: PTP-1B, PTP-HA2, PTP1B, tyrosine-protein phosphatase non-receptor type 1, protein-protein-tyrosine phosphatase HA2, protein-tyrosine phosphatase 1B, protein-tyrosine phosphatase HA2
Species: mouse
Products:     Ptpn1

Top Publications

  1. Heinonen K, Dubé N, Bourdeau A, Lapp W, Tremblay M. Protein tyrosine phosphatase 1B negatively regulates macrophage development through CSF-1 signaling. Proc Natl Acad Sci U S A. 2006;103:2776-81 pubmed
    b>Protein tyrosine phosphatase 1B (PTP-1B) is a ubiquitously expressed cytosolic phosphatase with the ability to dephosphorylate JAK2 and TYK2, and thereby down-regulate cytokine receptor signaling...
  2. Dadke S, Cotteret S, Yip S, Jaffer Z, Haj F, Ivanov A, et al. Regulation of protein tyrosine phosphatase 1B by sumoylation. Nat Cell Biol. 2007;9:80-5 pubmed
    Protein-tyrosine phosphatase 1B (PTP1B) is an ubiquitously expressed enzyme that negatively regulates growth-factor signalling and cell proliferation by binding to and dephosphorylating key receptor tyrosine kinases, such as the insulin ..
  3. Delibegovic M, Zimmer D, Kauffman C, Rak K, Hong E, Cho Y, et al. Liver-specific deletion of protein-tyrosine phosphatase 1B (PTP1B) improves metabolic syndrome and attenuates diet-induced endoplasmic reticulum stress. Diabetes. 2009;58:590-9 pubmed publisher
    The protein tyrosine phosphatase PTP1B is a negative regulator of insulin signaling; consequently, mice deficient in PTP1B are hypersensitive to insulin...
  4. Xue B, Pulinilkunnil T, Murano I, Bence K, He H, Minokoshi Y, et al. Neuronal protein tyrosine phosphatase 1B deficiency results in inhibition of hypothalamic AMPK and isoform-specific activation of AMPK in peripheral tissues. Mol Cell Biol. 2009;29:4563-73 pubmed publisher
    b>PTP1B(-/-) mice are resistant to diet-induced obesity due to leptin hypersensitivity and consequent increased energy expenditure. We aimed to determine the cellular mechanisms underlying this metabolic state...
  5. Berdnikovs S, Pavlov V, Abdala Valencia H, McCary C, Klumpp D, Tremblay M, et al. PTP1B deficiency exacerbates inflammation and accelerates leukocyte trafficking in vivo. J Immunol. 2012;188:874-84 pubmed publisher
    It is reported that PTP1B limits cytokine signaling in vitro. However, PTP1B's function during inflammation in vivo is not known. In this report, we determined whether PTP1B deficiency affects allergic inflammation in vivo...
  6. Sangwan V, Paliouras G, Cheng A, Dubé N, Tremblay M, Park M. Protein-tyrosine phosphatase 1B deficiency protects against Fas-induced hepatic failure. J Biol Chem. 2006;281:221-8 pubmed
    Genetic disruption of protein-tyrosine phosphatase 1B (PTP1B) in mice leads to increased insulin sensitivity and resistance to weight gain...
  7. Gonzalez Rodriguez A, Mas Gutierrez J, Mirasierra M, Fernandez Perez A, Lee Y, Ko H, et al. Essential role of protein tyrosine phosphatase 1B in obesity-induced inflammation and peripheral insulin resistance during aging. Aging Cell. 2012;11:284-96 pubmed publisher
    b>Protein tyrosine phosphatase 1B (PTP1B) is a negative regulator of insulin signaling and a therapeutic target for type 2 diabetes (T2DM)...
  8. Kushner J, Haj F, Klaman L, Dow M, Kahn B, Neel B, et al. Islet-sparing effects of protein tyrosine phosphatase-1b deficiency delays onset of diabetes in IRS2 knockout mice. Diabetes. 2004;53:61-6 pubmed
    Protein tyrosine phosphatase-1b (Ptp1b) inhibits insulin and leptin signaling by dephosphorylating specific tyrosine residues in their activated receptor complexes...
  9. Gonzalez Rodriguez A, Clampit J, Escribano O, Benito M, Rondinone C, Valverde A. Developmental switch from prolonged insulin action to increased insulin sensitivity in protein tyrosine phosphatase 1B-deficient hepatocytes. Endocrinology. 2007;148:594-608 pubmed
    b>Protein tyrosine phosphatase 1B (PTP1B) is a negative regulator of insulin signaling and a therapeutic target for type 2 diabetes...

More Information

Publications62

  1. Rondinone C, Trevillyan J, Clampit J, Gum R, Berg C, Kroeger P, et al. Protein tyrosine phosphatase 1B reduction regulates adiposity and expression of genes involved in lipogenesis. Diabetes. 2002;51:2405-11 pubmed
    b>Protein tyrosine phosphatase 1B (PTP1B) has been implicated as a negative regulator of insulin action. Overexpression of PTP1B protein has been observed in insulin-resistant states associated with obesity...
  2. Cheng A, Uetani N, Simoncic P, Chaubey V, Lee Loy A, McGlade C, et al. Attenuation of leptin action and regulation of obesity by protein tyrosine phosphatase 1B. Dev Cell. 2002;2:497-503 pubmed
    ..Mice deficient in protein tyrosine phosphatase 1B (PTP1B) are resistant to diabetes and diet-induced obesity, prompting us to further define the ..
  3. Zabolotny J, Bence Hanulec K, Stricker Krongrad A, Haj F, Wang Y, Minokoshi Y, et al. PTP1B regulates leptin signal transduction in vivo. Dev Cell. 2002;2:489-95 pubmed
    Mice lacking the protein-tyrosine phosphatase PTP1B are hypersensitive to insulin and resistant to obesity. However, the molecular basis for resistance to obesity has been unclear. Here we show that PTP1B regulates leptin signaling...
  4. Rhee J, Lilien J, Balsamo J. Essential tyrosine residues for interaction of the non-receptor protein-tyrosine phosphatase PTP1B with N-cadherin. J Biol Chem. 2001;276:6640-4 pubmed
    Expression of a dominant-negative, catalytically inactive form of the nonreceptor protein-tyrosine phosphatase PTP1B in L-cells constitutively expressing N-cadherin results in loss of N-cadherin-mediated cell-cell adhesion...
  5. Ruffolo S, Forsell P, Yuan X, Desmarais S, Himms Hagen J, Cromlish W, et al. Basal activation of p70S6K results in adipose-specific insulin resistance in protein-tyrosine phosphatase 1B -/- mice. J Biol Chem. 2007;282:30423-33 pubmed
  6. Zabolotny J, Kim Y, Welsh L, Kershaw E, Neel B, Kahn B. Protein-tyrosine phosphatase 1B expression is induced by inflammation in vivo. J Biol Chem. 2008;283:14230-41 pubmed publisher
    Protein-tyrosine phosphatase 1B (PTP1B) is a major negative regulator of insulin and leptin sensitivity. PTP1B overexpression in adipose tissue and skeletal muscle of humans and rodents may contribute to insulin resistance and obesity...
  7. Lessard L, Stuible M, Tremblay M. The two faces of PTP1B in cancer. Biochim Biophys Acta. 2010;1804:613-9 pubmed publisher
    b>PTP1B is a classical non-transmembrane protein tyrosine phosphatase that plays a key role in metabolic signaling and is a promising drug target for type 2 diabetes and obesity...
  8. Miranda S, Gonzalez Rodriguez A, Revuelta Cervantes J, Rondinone C, Valverde A. Beneficial effects of PTP1B deficiency on brown adipocyte differentiation and protection against apoptosis induced by pro- and anti-inflammatory stimuli. Cell Signal. 2010;22:645-59 pubmed publisher
    ..the importance of brown adipose tissue (BAT) for basal thermogenic energy expenditure, we investigated the role of PTP1B in the acquisition of terminal differentiated phenotype and in the apoptotic responses of brown adipocytes...
  9. Lin H, Yu I, Wang R, Chen Y, Liu N, Altuwaijri S, et al. Increased hepatic steatosis and insulin resistance in mice lacking hepatic androgen receptor. Hepatology. 2008;47:1924-35 pubmed publisher
    ..AR agonists that specifically target hepatic AR might be developed to provide a better strategy for treatment of metabolic syndrome in men. ..
  10. Gonzalez Rodriguez A, Mas Gutierrez J, Sanz González S, Ros M, Burks D, Valverde A. Inhibition of PTP1B restores IRS1-mediated hepatic insulin signaling in IRS2-deficient mice. Diabetes. 2010;59:588-99 pubmed publisher
    ..regulation of liver metabolism, we used genetic and pharmacological approaches to study the effects of inhibiting PTP1B on hepatic insulin signaling and expression of gluconeogenic enzymes in IRS2(-/-) mice...
  11. Delibegovic M, Bence K, Mody N, Hong E, Ko H, Kim J, et al. Improved glucose homeostasis in mice with muscle-specific deletion of protein-tyrosine phosphatase 1B. Mol Cell Biol. 2007;27:7727-34 pubmed
    Obesity and type 2 diabetes are characterized by insulin resistance. Mice lacking the protein-tyrosine phosphatase PTP1B in all tissues are hypersensitive to insulin but also have diminished fat stores...
  12. Berdnikovs S, Abdala Valencia H, Cook Mills J. Endothelial cell PTP1B regulates leukocyte recruitment during allergic inflammation. Am J Physiol Lung Cell Mol Physiol. 2013;304:L240-9 pubmed publisher
    ..Ligation of VCAM-1 activates endothelial cell protein tyrosine phosphatase 1B (PTP1B), which is required for VCAM-1-dependent leukocyte migration in vitro...
  13. Lam N, Lewis J, Cheung A, Luk C, Tse J, Wang J, et al. Leptin increases hepatic insulin sensitivity and protein tyrosine phosphatase 1B expression. Mol Endocrinol. 2004;18:1333-45 pubmed
    ..by which leptin up-regulates hepatic IR activation, we examined the expression of the protein tyrosine phosphatase PTP1B, recently implicated as an important negative regulator of insulin signaling...
  14. Gu F, Dubé N, Kim J, Cheng A, Ibarra Sanchez M, Tremblay M, et al. Protein tyrosine phosphatase 1B attenuates growth hormone-mediated JAK2-STAT signaling. Mol Cell Biol. 2003;23:3753-62 pubmed
    ..These results indicate that PTP-1B regulates GH signaling by reducing the extent of JAK2 phosphorylation and suggest that PTP-1B is essential for limiting the action of GH during metabolic stress such as fasting. ..
  15. Zabolotny J, Haj F, Kim Y, Kim H, Shulman G, Kim J, et al. Transgenic overexpression of protein-tyrosine phosphatase 1B in muscle causes insulin resistance, but overexpression with leukocyte antigen-related phosphatase does not additively impair insulin action. J Biol Chem. 2004;279:24844-51 pubmed
    Previous studies implicate protein-tyrosine phosphatase 1B (PTP1B) and leukocyte antigen-related phosphatase (LAR) as negative regulators of insulin signaling...
  16. Elchebly M, Payette P, Michaliszyn E, Cromlish W, Collins S, Loy A, et al. Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene. Science. 1999;283:1544-8 pubmed
    ..These results demonstrate that PTP-1B has a major role in modulating both insulin sensitivity and fuel metabolism, thereby establishing it as a potential therapeutic target in the treatment of type 2 diabetes and obesity. ..
  17. Xu H, An H, Hou J, Han C, Wang P, Yu Y, et al. Phosphatase PTP1B negatively regulates MyD88- and TRIF-dependent proinflammatory cytokine and type I interferon production in TLR-triggered macrophages. Mol Immunol. 2008;45:3545-52 pubmed publisher
    ..Protein tyrosine phosphatase-1B (PTP1B) has been shown to be a critical negative regulator of insulin pathway and other cellular signaling, however, ..
  18. Julien S, Dubé N, Read M, Penney J, Paquet M, Han Y, et al. Protein tyrosine phosphatase 1B deficiency or inhibition delays ErbB2-induced mammary tumorigenesis and protects from lung metastasis. Nat Genet. 2007;39:338-46 pubmed
    We investigated the role of protein tyrosine phosphatase 1B (PTP1B) in mammary tumorigenesis using both genetic and pharmacological approaches...
  19. Haj F, Markova B, Klaman L, Bohmer F, Neel B. Regulation of receptor tyrosine kinase signaling by protein tyrosine phosphatase-1B. J Biol Chem. 2003;278:739-44 pubmed
    ..Based on in vitro and ex vivo studies, protein tyrosine phosphatase-1B (PTP1B) was implicated in the regulation of several RTKs, yet mice lacking PTP1B show defects mainly in insulin and ..
  20. Bence K, Delibegovic M, Xue B, Gorgun C, Hotamisligil G, Neel B, et al. Neuronal PTP1B regulates body weight, adiposity and leptin action. Nat Med. 2006;12:917-24 pubmed
    ..We generated tissue-specific PTP1B knockout (Ptpn1(-/-)) mice...
  21. Persson C, Sävenhed C, Bourdeau A, Tremblay M, Markova B, Bohmer F, et al. Site-selective regulation of platelet-derived growth factor beta receptor tyrosine phosphorylation by T-cell protein tyrosine phosphatase. Mol Cell Biol. 2004;24:2190-201 pubmed
    ..In summary, our findings identify TC-PTP as a previously unrecognized negative regulator of PDGF beta receptor signaling and support the general notion that PTPs display site selectivity in their action on tyrosine kinase receptors. ..
  22. Bettaieb A, Liu S, Xi Y, Nagata N, Matsuo K, Matsuo I, et al. Differential regulation of endoplasmic reticulum stress by protein tyrosine phosphatase 1B and T cell protein tyrosine phosphatase. J Biol Chem. 2011;286:9225-35 pubmed publisher
    Protein-tyrosine phosphatase 1B (PTP1B) and T cell protein-tyrosine phosphatase (TCPTP) are closely related intracellular phosphatases implicated in the control of glucose homeostasis...
  23. Matsuo K, Bettaieb A, Nagata N, Matsuo I, Keilhack H, Haj F. Regulation of brown fat adipogenesis by protein tyrosine phosphatase 1B. PLoS ONE. 2011;6:e16446 pubmed publisher
    Protein-tyrosine phosphatase 1B (PTP1B) is a physiological regulator of insulin signaling and energy balance, but its role in brown fat adipogenesis requires additional investigation...
  24. Gu F, Nguyen D, Stuible M, Dubé N, Tremblay M, Chevet E. Protein-tyrosine phosphatase 1B potentiates IRE1 signaling during endoplasmic reticulum stress. J Biol Chem. 2004;279:49689-93 pubmed
    ..We demonstrate that PTP-1B is not just a passive resident of the ER but on the contrary has an essential role in potentiating IRE1-mediated ER stress signaling pathways. ..
  25. Bettaieb A, Matsuo K, Matsuo I, Wang S, Melhem R, Koromilas A, et al. Protein tyrosine phosphatase 1B deficiency potentiates PERK/eIF2? signaling in brown adipocytes. PLoS ONE. 2012;7:e34412 pubmed publisher
    Protein-tyrosine phosphatase 1B (PTP1B) is a physiological regulator of glucose homeostasis and body mass, and has been implicated in endoplasmic reticulum (ER) stress...
  26. Owen C, Czopek A, Agouni A, Grant L, Judson R, Lees E, et al. Adipocyte-specific protein tyrosine phosphatase 1B deletion increases lipogenesis, adipocyte cell size and is a minor regulator of glucose homeostasis. PLoS ONE. 2012;7:e32700 pubmed publisher
    b>Protein tyrosine phosphatase 1B (PTP1B), a key negative regulator of leptin and insulin signaling, is positively correlated with adiposity and contributes to insulin resistance...
  27. White C, Whittington A, Barnes M, Wang Z, Bray G, Morrison C. HF diets increase hypothalamic PTP1B and induce leptin resistance through both leptin-dependent and -independent mechanisms. Am J Physiol Endocrinol Metab. 2009;296:E291-9 pubmed publisher
    b>Protein tyrosine phosphatase 1B (PTP1B) contributes to leptin resistance by inhibiting intracellular leptin receptor signaling...
  28. Mohammadtaghvaei N, Taheripak G, Taghikhani M, Meshkani R. Palmitate-induced PTP1B expression is mediated by ceramide-JNK and nuclear factor ?B (NF-?B) activation. Cell Signal. 2012;24:1964-70 pubmed publisher
    Palmitate induces PTP1B expression in skeletal muscle cells. The purpose of this study was to investigate the mechanisms responsible for palmitate-induced PTP1B expression in mouse skeletal muscle cells...
  29. Bentires Alj M, Neel B. Protein-tyrosine phosphatase 1B is required for HER2/Neu-induced breast cancer. Cancer Res. 2007;67:2420-4 pubmed
    The protein-tyrosine phosphatase 1B (PTP1B; PTPN1) is an important regulator of mammalian metabolism and also helps control signaling by growth factors, cytokines, and extracellular matrix...
  30. Yi T, Cleveland J, Ihle J. Identification of novel protein tyrosine phosphatases of hematopoietic cells by polymerase chain reaction amplification. Blood. 1991;78:2222-8 pubmed
    ..Two of the cDNA sequences were 95% identical to human PTP epsilon (HPTP epsilon) and rat brain PTP (PTP1B), respectively, and are likely to represent their murine homologs...
  31. Sun C, Zhang F, Ge X, Yan T, Chen X, Shi X, et al. SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B. Cell Metab. 2007;6:307-19 pubmed
    ..5 mg/kg/day. Further studies demonstrated that the effect of SIRT1 on insulin resistance is mediated by repressing PTP1B transcription at the chromatin level...
  32. Klaman L, Boss O, Peroni O, Kim J, Martino J, Zabolotny J, et al. Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice. Mol Cell Biol. 2000;20:5479-89 pubmed
    ..Our results identify PTP-1B as a major regulator of energy balance, insulin sensitivity, and body fat stores in vivo. ..
  33. Hernández M, Sala M, Balsamo J, Lilien J, Arregui C. ER-bound PTP1B is targeted to newly forming cell-matrix adhesions. J Cell Sci. 2006;119:1233-43 pubmed
    Here, we define the mechanism through which protein tyrosine phosphatase 1B (PTP1B) is targeted to cell-matrix adhesion sites...
  34. Buckley D, Cheng A, Kiely P, Tremblay M, O Connor R. Regulation of insulin-like growth factor type I (IGF-I) receptor kinase activity by protein tyrosine phosphatase 1B (PTP-1B) and enhanced IGF-I-mediated suppression of apoptosis and motility in PTP-1B-deficient fibroblasts. Mol Cell Biol. 2002;22:1998-2010 pubmed
    ..Here we investigated the regulation of IGF-IR activation and function by protein tyrosine phosphatase 1B (PTP-1B)...
  35. Waring J, Ciurlionis R, Clampit J, Morgan S, Gum R, Jolly R, et al. PTP1B antisense-treated mice show regulation of genes involved in lipogenesis in liver and fat. Mol Cell Endocrinol. 2003;203:155-68 pubmed
    ..have shown that in insulin resistant and diabetic ob/ob and db/db mice, reducing the levels of protein tyrosine phosphatase 1B (PTP1B) protein by treatment with a PTP1B antisense oligonucleotide resulted in improved insulin ..
  36. Dubé N, Cheng A, Tremblay M. The role of protein tyrosine phosphatase 1B in Ras signaling. Proc Natl Acad Sci U S A. 2004;101:1834-9 pubmed
    ..Surprisingly, we show that platelet-derived growth factor-stimulated extracellular-regulated kinase signaling in PTP1B-deficient cells is not significantly hyperactivated...
  37. Galic S, Hauser C, Kahn B, Haj F, Neel B, Tonks N, et al. Coordinated regulation of insulin signaling by the protein tyrosine phosphatases PTP1B and TCPTP. Mol Cell Biol. 2005;25:819-29 pubmed
    The protein tyrosine phosphatase PTP1B is a negative regulator of insulin signaling and a therapeutic target for type 2 diabetes...
  38. Agouni A, Mody N, Owen C, Czopek A, Zimmer D, Bentires Alj M, et al. Liver-specific deletion of protein tyrosine phosphatase (PTP) 1B improves obesity- and pharmacologically induced endoplasmic reticulum stress. Biochem J. 2011;438:369-78 pubmed publisher
    ..PTP1B (protein tyrosine phosphatase 1B) is a major regulator of adiposity and insulin sensitivity...
  39. Zinker B, Rondinone C, Trevillyan J, Gum R, Clampit J, Waring J, et al. PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic mice. Proc Natl Acad Sci U S A. 2002;99:11357-62 pubmed
    The role of protein-tyrosine phosphatase 1B (PTP1B) in diabetes was investigated using an antisense oligonucleotide in ob/ob and db/db mice...
  40. Haj F, Zabolotny J, Kim Y, Kahn B, Neel B. Liver-specific protein-tyrosine phosphatase 1B (PTP1B) re-expression alters glucose homeostasis of PTP1B-/-mice. J Biol Chem. 2005;280:15038-46 pubmed
    Protein-tyrosine phosphatase 1B (PTP1B) is an important negative regulator of insulin and leptin signaling in vivo. Mice lacking PTP1B (PTP1B-/- mice) are hyper-responsive to insulin and leptin and resistant to diet-induced obesity...
  41. Nieto Vazquez I, Fernández Veledo S, de Alvaro C, Rondinone C, Valverde A, Lorenzo M. Protein-tyrosine phosphatase 1B-deficient myocytes show increased insulin sensitivity and protection against tumor necrosis factor-alpha-induced insulin resistance. Diabetes. 2007;56:404-13 pubmed
    ..In this study, we have assessed the role of PTP1B in the insulin sensitivity of skeletal muscle under physiological and insulin-resistant conditions...
  42. Heinonen K, Bourdeau A, Doody K, Tremblay M. Protein tyrosine phosphatases PTP-1B and TC-PTP play nonredundant roles in macrophage development and IFN-gamma signaling. Proc Natl Acad Sci U S A. 2009;106:9368-72 pubmed publisher
    ..b>Protein tyrosine phosphatase 1B (PTP-1B) and T cell protein tyrosine phosphatase (TC-PTP) are 2 closely related phosphatases known to ..
  43. Gonzalez Rodriguez A, Escribano O, Alba J, Rondinone C, Benito M, Valverde A. Levels of protein tyrosine phosphatase 1B determine susceptibility to apoptosis in serum-deprived hepatocytes. J Cell Physiol. 2007;212:76-88 pubmed
    b>Protein tyrosine phosphatase 1B (PTP1B) is a negative regulator of tyrosine kinase growth factor signaling...
  44. Xue B, Kim Y, Lee A, Toschi E, Bonner Weir S, Kahn C, et al. Protein-tyrosine phosphatase 1B deficiency reduces insulin resistance and the diabetic phenotype in mice with polygenic insulin resistance. J Biol Chem. 2007;282:23829-40 pubmed
    ..Protein-tyrosine phosphatase 1B (PTP1B) dephosphorylates tyrosine residues in IR and possibly IRS proteins, thereby inhibiting insulin signaling...
  45. Carbone C, Zheng H, Bhattacharya S, Lewis J, Reiter A, Henthorn P, et al. Protein tyrosine phosphatase 1B is a key regulator of IFNAR1 endocytosis and a target for antiviral therapies. Proc Natl Acad Sci U S A. 2012;109:19226-31 pubmed publisher
    ..An RNAi-based screen identified PTP1B as a specific regulator of IFNAR1 endocytosis stimulated by IFN1, but not by ligand-independent inducers of IFNAR1 ..
  46. Panzhinskiy E, Hua Y, Culver B, Ren J, Nair S. Endoplasmic reticulum stress upregulates protein tyrosine phosphatase 1B and impairs glucose uptake in cultured myotubes. Diabetologia. 2013;56:598-607 pubmed publisher
    ..b>Protein tyrosine phosphatase 1B (PTP1B) is a negative regulator of insulin signalling and is localised on the ER membrane...
  47. Zhang J, Wang B, Zhang W, Wei Y, Bian Z, Zhang C, et al. Protein tyrosine phosphatase 1B deficiency ameliorates murine experimental colitis via the expansion of myeloid-derived suppressor cells. PLoS ONE. 2013;8:e70828 pubmed publisher
    b>Protein tyrosine phosphatase 1B (PTP1B) is a key molecule in modulating low-degree inflammatory conditions such as diabetes. The role of PTP1B in other chronic inflammations, however, remains unknown...
  48. Revuelta Cervantes J, Mayoral R, Miranda S, Gonzalez Rodriguez A, Fernandez M, Martín Sanz P, et al. Protein Tyrosine Phosphatase 1B (PTP1B) deficiency accelerates hepatic regeneration in mice. Am J Pathol. 2011;178:1591-604 pubmed publisher
    b>Protein tyrosine phosphatase 1B (PTP1B) is a key regulator of metabolism and cell growth by its ability to dephosphorylate tyrosine kinase receptors and modulate the intensity of their signaling cascades...
  49. Dubé N, Bourdeau A, Heinonen K, Cheng A, Loy A, Tremblay M. Genetic ablation of protein tyrosine phosphatase 1B accelerates lymphomagenesis of p53-null mice through the regulation of B-cell development. Cancer Res. 2005;65:10088-95 pubmed
    b>Protein tyrosine phosphatase 1B (PTP1B) is involved in multiple signaling pathways by down-regulating several tyrosine kinases...
  50. Banno R, Zimmer D, De Jonghe B, Atienza M, Rak K, Yang W, et al. PTP1B and SHP2 in POMC neurons reciprocally regulate energy balance in mice. J Clin Invest. 2010;120:720-34 pubmed publisher
    b>Protein tyrosine phosphatase 1B (PTP1B) and SH2 domain-containing protein tyrosine phosphatase-2 (SHP2) have been shown in mice to regulate metabolism via the central nervous system, but the specific neurons mediating these effects are ..
  51. Deem T, Abdala Valencia H, Cook Mills J. VCAM-1 activation of endothelial cell protein tyrosine phosphatase 1B. J Immunol. 2007;178:3865-73 pubmed
    ..In this report, we identify a role for protein tyrosine phosphatase 1B (PTP1B) in the VCAM-1 signaling pathway...
  52. Belin De Chantemele E, Muta K, MINTZ J, Tremblay M, Marrero M, Fulton D, et al. Protein tyrosine phosphatase 1B, a major regulator of leptin-mediated control of cardiovascular function. Circulation. 2009;120:753-63 pubmed publisher
    Obesity causes hypertension and sympathoactivation, a process proposed to be mediated by leptin. Protein tyrosine phosphatase 1B (PTP1B), a major new pharmaceutical target in the treatment of obesity and type II diabetes mellitus, ..
  53. Lu X, Malumbres R, Shields B, Jiang X, Sarosiek K, Natkunam Y, et al. PTP1B is a negative regulator of interleukin 4-induced STAT6 signaling. Blood. 2008;112:4098-108 pubmed publisher
    b>Protein tyrosine phosphatase 1B (PTP1B) is a ubiquitously expressed enzyme shown to negatively regulate multiple tyrosine phosphorylation-dependent signaling pathways...