Gene Symbol: Ptpmt1
Description: protein tyrosine phosphatase, mitochondrial 1
Alias: 1110001D10Rik, 2810004N20Rik, PLIP, phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1, PTEN-like phosphatase, phosphoinositide lipid phosphatase
Pagliarini D, Worby C, Dixon J. A PTEN-like phosphatase with a novel substrate specificity. J Biol Chem. 2004;279:38590-6 pubmed
We show that a novel PTEN-like phosphatase (PLIP) exhibits a unique preference for phosphatidylinositol 5-phosphate (PI(5)P) as a substrate in vitro...
Pagliarini D, Wiley S, Kimple M, Dixon J, Kelly P, Worby C, et al
. Involvement of a mitochondrial phosphatase in the regulation of ATP production and insulin secretion in pancreatic beta cells. Mol Cell. 2005;19:197-207 pubmed
..We have discovered that a member of the dual-specific protein tyrosine phosphatase (DS-PTP) family, PTPMT1 (PTP localized to the Mitochondrion 1) resides nearly exclusively in mitochondria...
Wiley S, Murphy A, Ross S, van der Geer P, Dixon J. MitoNEET is an iron-containing outer mitochondrial membrane protein that regulates oxidative capacity. Proc Natl Acad Sci U S A. 2007;104:5318-23 pubmed
..Cardiac mitochondria isolated from mitoNEET-null mice demonstrate a reduced oxidative capacity, suggesting that mito- NEET is an important iron-containing protein involved in the control of maximal mitochondrial respiratory rates. ..
Rardin M, Wiley S, Murphy A, Pagliarini D, Dixon J. Dual specificity phosphatases 18 and 21 target to opposing sides of the mitochondrial inner membrane. J Biol Chem. 2008;283:15440-50 pubmed publisher
..This work rigorously demonstrates the unique location of two highly similar DSPs on opposing sides of the mitochondrial inner membrane...
Shen J, Liu X, Yu W, Liu J, Nibbelink M, Guo C, et al
. A critical role of mitochondrial phosphatase Ptpmt1 in embryogenesis reveals a mitochondrial metabolic stress-induced differentiation checkpoint in embryonic stem cells. Mol Cell Biol. 2011;31:4902-16 pubmed publisher
..Global disruption of Ptpmt1, a mitochondrial Pten-like phosphatidylinositol phosphate (PIP) phosphatase, resulted in developmental arrest and ..
Yu W, Liu X, Shen J, Jovanović O, Pohl E, Gerson S, et al
. Metabolic regulation by the mitochondrial phosphatase PTPMT1 is required for hematopoietic stem cell differentiation. Cell Stem Cell. 2013;12:62-74 pubmed publisher
..Here we report that depletion of PTPMT1, a PTEN-like mitochondrial phosphatase, in inducible or hematopoietic-cell-specific knockout mice resulted in ..
Zhang J, Guan Z, Murphy A, Wiley S, Perkins G, Worby C, et al
. Mitochondrial phosphatase PTPMT1 is essential for cardiolipin biosynthesis. Cell Metab. 2011;13:690-700 pubmed publisher
b>PTPMT1 was the first protein tyrosine phosphatase found localized to the mitochondria, but its biological function was unknown...