Ptk2

Summary

Gene Symbol: Ptk2
Description: PTK2 protein tyrosine kinase 2
Alias: FADK 1, FAK, FRNK, Fadk, p125FAK, focal adhesion kinase 1, focal adhesion kinase-related nonkinase, focal ashension kinase 1, pp125FAK, protein-tyrosine kinase 2
Species: mouse
Products:     Ptk2

Top Publications

  1. Pirone D, Liu W, Ruiz S, Gao L, Raghavan S, Lemmon C, et al. An inhibitory role for FAK in regulating proliferation: a link between limited adhesion and RhoA-ROCK signaling. J Cell Biol. 2006;174:277-88 pubmed
    ..displacement of FAK from adhesions by using a FAK-/- cell line or by expressing the C-terminal fragment FRNK also caused an escape of adhesion-regulated growth arrest, suggesting dual positive and negative roles for FAK in ..
  2. Young S, Gerard O Riley R, Kim J, Pavalko F. Focal adhesion kinase is important for fluid shear stress-induced mechanotransduction in osteoblasts. J Bone Miner Res. 2009;24:411-24 pubmed publisher
    ..Focal adhesions are prime candidates for transducing external stimuli. Focal adhesion kinase (FAK), a nonreceptor tyrosine kinase found in focal adhesions, may play a key role in mechanotransduction, although its ..
  3. Ballestrem C, Erez N, Kirchner J, Kam Z, Bershadsky A, Geiger B. Molecular mapping of tyrosine-phosphorylated proteins in focal adhesions using fluorescence resonance energy transfer. J Cell Sci. 2006;119:866-75 pubmed
    ..interactions and tyrosine phosphorylation of paxillin, Crk-associated substrate (CAS), and focal adhesion kinase (FAK) in focal adhesions...
  4. Schlaepfer D, Hunter T. Evidence for in vivo phosphorylation of the Grb2 SH2-domain binding site on focal adhesion kinase by Src-family protein-tyrosine kinases. Mol Cell Biol. 1996;16:5623-33 pubmed
    Focal adhesion kinase (FAK) is a nonreceptor protein-tyrosine kinase (PTK) that associates with integrin receptors and participates in extracellular matrix-mediated signal transduction events...
  5. Liu Y, Loijens J, Martin K, Karginov A, Parsons J. The association of ASAP1, an ADP ribosylation factor-GTPase activating protein, with focal adhesion kinase contributes to the process of focal adhesion assembly. Mol Biol Cell. 2002;13:2147-56 pubmed
    ..screens, we identified ASAP1 as a major binding partner of protein tyrosine kinase focal adhesion kinase (FAK)...
  6. Braren R, Hu H, Kim Y, Beggs H, Reichardt L, Wang R. Endothelial FAK is essential for vascular network stability, cell survival, and lamellipodial formation. J Cell Biol. 2006;172:151-62 pubmed
    ..To investigate the cellular mechanism underlying this process, we deleted focal adhesion kinase (FAK), a key signaling mediator, in endothelial cells (ECs) using Tie2-Cre mice...
  7. Lee J, Borboa A, Chun H, Baird A, Eliceiri B. Conditional deletion of the focal adhesion kinase FAK alters remodeling of the blood-brain barrier in glioma. Cancer Res. 2010;70:10131-40 pubmed publisher
    ..Using a conditional, endothelium-specific deletion of the focal adhesion kinase (FAK) in the mouse (FAK CKO), we show that FAK is critical for destabilization of the tumor endothelium in tumor-bearing ..
  8. McLean G, Brown K, Arbuckle M, Wyke A, Pikkarainen T, Ruoslahti E, et al. Decreased focal adhesion kinase suppresses papilloma formation during experimental mouse skin carcinogenesis. Cancer Res. 2001;61:8385-9 pubmed
    Although focal adhesion kinase (FAK) is elevated in epithelial cancers, it is not known whether FAK expression influences tumor development in vivo...
  9. Lim S, Chen X, Lim Y, Hanson D, Vo T, Howerton K, et al. Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation. Mol Cell. 2008;29:9-22 pubmed publisher
    b>FAK is known as an integrin- and growth factor-associated tyrosine kinase promoting cell motility. Here we show that, during mouse development, FAK inactivation results in p53- and p21-dependent mesodermal cell growth arrest...

More Information

Publications94

  1. Boutahar N, Guignandon A, Vico L, Lafage Proust M. Mechanical strain on osteoblasts activates autophosphorylation of focal adhesion kinase and proline-rich tyrosine kinase 2 tyrosine sites involved in ERK activation. J Biol Chem. 2004;279:30588-99 pubmed
    ..CS rapidly and time-dependently promoted phosphorylation of both ERK2 at Tyr-187 and focal adhesion kinase (FAK) at Tyr-397 and Tyr-925, leading to the activation of the Ras/Raf/MEK pathway...
  2. Roy S, Ruest P, Hanks S. FAK regulates tyrosine phosphorylation of CAS, paxillin, and PYK2 in cells expressing v-Src, but is not a critical determinant of v-Src transformation. J Cell Biochem. 2002;84:377-88 pubmed
    b>FAK (focal adhesion kinase) is a nonreceptor protein-tyrosine kinase activated by tyrosine phosphorylation following integrin-mediated cell adhesion...
  3. Bisht B, Srinivasan K, Dey C. In vivo inhibition of focal adhesion kinase causes insulin resistance. J Physiol. 2008;586:3825-37 pubmed publisher
    Focal adhesion kinase (FAK), a non-receptor tyrosine kinase, has recently been implicated in the regulation of insulin resistance in vitro. However, its in vivo validation has not been attempted due to lethality of FAK knockout...
  4. Provenzano P, Inman D, Eliceiri K, Beggs H, Keely P. Mammary epithelial-specific disruption of focal adhesion kinase retards tumor formation and metastasis in a transgenic mouse model of human breast cancer. Am J Pathol. 2008;173:1551-65 pubmed publisher
    Focal adhesion kinase (FAK) is a central regulator of the focal adhesion, influencing cell proliferation, survival, and migration...
  5. Ilic D, Kovacic B, McDonagh S, Jin F, Baumbusch C, Gardner D, et al. Focal adhesion kinase is required for blood vessel morphogenesis. Circ Res. 2003;92:300-7 pubmed
    The nonreceptor tyrosine kinase focal adhesion kinase (FAK) is a point of convergence for signals from extracellular matrix, soluble factors, and mechanical stimuli...
  6. Torsoni A, Constancio S, Nadruz W, Hanks S, Franchini K. Focal adhesion kinase is activated and mediates the early hypertrophic response to stretch in cardiac myocytes. Circ Res. 2003;93:140-7 pubmed
    Previously we reported that the rapid activation of the Fak/Src multicomponent signaling complex mediates load-induced activation of growth and survival signaling pathways in adult rat heart...
  7. Serrels B, Serrels A, Brunton V, Holt M, McLean G, Gray C, et al. Focal adhesion kinase controls actin assembly via a FERM-mediated interaction with the Arp2/3 complex. Nat Cell Biol. 2007;9:1046-56 pubmed
    ..How integrins signal to the Arp2/3 complex is not well understood. Here, we show that focal adhesion kinase (FAK) and the Arp2/3 complex associate and colocalize at transient structures formed early after adhesion...
  8. Tomar A, Lim S, Lim Y, Schlaepfer D. A FAK-p120RasGAP-p190RhoGAP complex regulates polarity in migrating cells. J Cell Sci. 2009;122:1852-62 pubmed publisher
    ..Focal adhesion kinase (FAK) promotes cell migration, but a molecular role for FAK in promoting cell polarity remains undefined...
  9. Rico B, Beggs H, Schahin Reed D, Kimes N, Schmidt A, Reichardt L. Control of axonal branching and synapse formation by focal adhesion kinase. Nat Neurosci. 2004;7:1059-69 pubmed
    ..Here we show that cell-specific ablation of the murine gene Ptk2 (more commonly known as fak), encoding focal adhesion kinase (FAK), increases the number of axonal terminals and ..
  10. Funakoshi Tago M, Sonoda Y, Tanaka S, Hashimoto K, Tago K, Tominaga S, et al. Tumor necrosis factor-induced nuclear factor kappaB activation is impaired in focal adhesion kinase-deficient fibroblasts. J Biol Chem. 2003;278:29359-65 pubmed
    Focal adhesion kinase (FAK) is widely involved in important cellular functions such as proliferation, migration, and survival, although its roles in immune and inflammatory responses have yet to be explored...
  11. Hayashi I, Vuori K, Liddington R. The focal adhesion targeting (FAT) region of focal adhesion kinase is a four-helix bundle that binds paxillin. Nat Struct Biol. 2002;9:101-6 pubmed
    Focal adhesion kinase (FAK) is a tyrosine kinase found in focal adhesions, intracellular signaling complexes that are formed following engagement of the extracellular matrix by integrins...
  12. Schlaepfer D, Hou S, Lim S, Tomar A, Yu H, Lim Y, et al. Tumor necrosis factor-alpha stimulates focal adhesion kinase activity required for mitogen-activated kinase-associated interleukin 6 expression. J Biol Chem. 2007;282:17450-9 pubmed
    Focal adhesion kinase (FAK) is a cytoplasmic protein-tyrosine kinase that promotes cell migration, survival, and gene expression...
  13. Shibue T, Weinberg R. Integrin beta1-focal adhesion kinase signaling directs the proliferation of metastatic cancer cells disseminated in the lungs. Proc Natl Acad Sci U S A. 2009;106:10290-5 pubmed publisher
    ..in which they undergo cell-cycle arrest resulting, in part, from insufficient activation of focal adhesion kinase (FAK)...
  14. Schlaepfer D, Broome M, Hunter T. Fibronectin-stimulated signaling from a focal adhesion kinase-c-Src complex: involvement of the Grb2, p130cas, and Nck adaptor proteins. Mol Cell Biol. 1997;17:1702-13 pubmed
    The focal adhesion kinase (FAK), a protein-tyrosine kinase (PTK), associates with integrin receptors and is activated by cell binding to extracellular matrix proteins, such as fibronectin (FN)...
  15. Zhao X, Peng X, Sun S, Park A, Guan J. Role of kinase-independent and -dependent functions of FAK in endothelial cell survival and barrier function during embryonic development. J Cell Biol. 2010;189:955-65 pubmed publisher
    Focal adhesion kinase (FAK) is essential for vascular development as endothelial cell (EC)-specific knockout of FAK (conditional FAK knockout [CFKO] mice) leads to embryonic lethality...
  16. Pylayeva Y, Gillen K, Gerald W, Beggs H, Reichardt L, Giancotti F. Ras- and PI3K-dependent breast tumorigenesis in mice and humans requires focal adhesion kinase signaling. J Clin Invest. 2009;119:252-66 pubmed publisher
    ..We report here that in a large fraction of human breast cancers, the gene encoding focal adhesion kinase (FAK), a core component of integrin signaling, was amplified and FAK mRNA was overexpressed...
  17. Pasapera A, Schneider I, Rericha E, Schlaepfer D, Waterman C. Myosin II activity regulates vinculin recruitment to focal adhesions through FAK-mediated paxillin phosphorylation. J Cell Biol. 2010;188:877-90 pubmed publisher
    ..We find that FA recruitment of both the cytoskeletal adapter protein vinculin and the tyrosine kinase FA kinase (FAK) are myosin II and extracellular matrix (ECM) stiffness dependent...
  18. Holinstat M, Knezevic N, Broman M, Samarel A, Malik A, Mehta D. Suppression of RhoA activity by focal adhesion kinase-induced activation of p190RhoGAP: role in regulation of endothelial permeability. J Biol Chem. 2006;281:2296-305 pubmed
    ..Inhibition of FAK by adenoviral expression of FRNK (a dominant negative FAK construct) in monolayers prevented p190RhoGAP phosphorylation, increased RhoA activity, ..
  19. Corsi J, Rouer E, Girault J, Enslen H. Organization and post-transcriptional processing of focal adhesion kinase gene. BMC Genomics. 2006;7:198 pubmed
    Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase critical for processes ranging from embryo development to cancer progression...
  20. Charlesworth P, Komiyama N, Grant S. Homozygous mutation of focal adhesion kinase in embryonic stem cell derived neurons: normal electrophysiological and morphological properties in vitro. BMC Neurosci. 2006;7:47 pubmed
    ..Here we report a study of focal adhesion kinase (FAK), which has been implicated in synapse formation and regulation of ion channels, using the ESN system to circumvent ..
  21. Westhoff M, Serrels B, Fincham V, Frame M, Carragher N. SRC-mediated phosphorylation of focal adhesion kinase couples actin and adhesion dynamics to survival signaling. Mol Cell Biol. 2004;24:8113-33 pubmed
    ..Many cell responses signal through focal adhesion kinase (FAK), often by integrin-induced autophosphorylation of FAK or phosphorylation by Src family kinases...
  22. Sandilands E, Serrels B, McEwan D, Morton J, Macagno J, McLeod K, et al. Autophagic targeting of Src promotes cancer cell survival following reduced FAK signalling. Nat Cell Biol. 2011;14:51-60 pubmed publisher
    Here we describe a mechanism that cancer cells use to survive when flux through the Src/FAK pathway is severely perturbed...
  23. Slack Davis J, Hershey E, Theodorescu D, Frierson H, Parsons J. Differential requirement for focal adhesion kinase signaling in cancer progression in the transgenic adenocarcinoma of mouse prostate model. Mol Cancer Ther. 2009;8:2470-7 pubmed publisher
    ..Focal adhesion kinase (FAK) is a nonreceptor protein tyrosine kinase that regulates adhesion-dependent cell signaling and has been implicated ..
  24. Greenberg R, Bernstein A, Benezra M, Gelman I, Taliana L, Masur S. FAK-dependent regulation of myofibroblast differentiation. FASEB J. 2006;20:1006-8 pubmed
    ..Because fibronectin signals are transmitted through focal adhesion kinase (FAK), it was predicted that FAK would be essential to TGFbeta-mediated myofibroblast differentiation...
  25. Polte T, Hanks S. Interaction between focal adhesion kinase and Crk-associated tyrosine kinase substrate p130Cas. Proc Natl Acad Sci U S A. 1995;92:10678-82 pubmed
    The focal adhesion kinase (FAK) has been implicated in integrin-mediated signaling events and in the mechanism of cell transformation by the v-Src and v-Crk oncoproteins...
  26. Moeller M, Shi Y, Reichardt L, Ethell I. EphB receptors regulate dendritic spine morphogenesis through the recruitment/phosphorylation of focal adhesion kinase and RhoA activation. J Biol Chem. 2006;281:1587-98 pubmed
    ..This appears to occur through assembly of an EphB-associated protein complex that includes focal adhesion kinase (FAK), Src, Grb2, and paxillin and the subsequent activations of FAK, Src, paxillin, and RhoA...
  27. Moissoglu K, Gelman I. v-Src rescues actin-based cytoskeletal architecture and cell motility and induces enhanced anchorage independence during oncogenic transformation of focal adhesion kinase-null fibroblasts. J Biol Chem. 2003;278:47946-59 pubmed
    The ability of the focal adhesion kinase (FAK) to integrate signals from extracellular matrix and growth factor receptors requires the integrity of Tyr397, a major autophosphorylation site that mediates the Src homology 2-dependent ..
  28. Grove M, Komiyama N, Nave K, Grant S, Sherman D, Brophy P. FAK is required for axonal sorting by Schwann cells. J Cell Biol. 2007;176:277-82 pubmed
    ..However, the signal transduction mechanisms are unknown. Focal adhesion kinase (FAK) has been linked to alpha6beta1 integrin and ErbB receptor signaling, and we show that myelination by Schwann cells ..
  29. Hauck C, Hunter T, Schlaepfer D. The v-Src SH3 domain facilitates a cell adhesion-independent association with focal adhesion kinase. J Biol Chem. 2001;276:17653-62 pubmed publisher
    ..Integrin signals are relayed in part by focal adhesion kinase (FAK) activation and the formation of a transient signaling complex initiated by Src homology 2 (SH2)-dependent binding ..
  30. Zhai J, Lin H, Nie Z, Wu J, Canete Soler R, Schlaepfer W, et al. Direct interaction of focal adhesion kinase with p190RhoGEF. J Biol Chem. 2003;278:24865-73 pubmed
    ..p190RhoGEF tyrosine phosphorylation, and co-transfection of a dominant-negative inhibitor of FAK activity, termed FRNK, inhibited lamininstimulated p190RhoGEF tyrosine phosphorylation and p21 RhoA GTP binding...
  31. Akhtar N, Streuli C. An integrin-ILK-microtubule network orients cell polarity and lumen formation in glandular epithelium. Nat Cell Biol. 2013;15:17-27 pubmed
    ..We propose that this integrin signalling network controls the delivery of apical components to the correct surface and thereby governs the orientation of polarity and development of lumens. ..
  32. Schlaepfer D, Hanks S, Hunter T, van der Geer P. Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase. Nature. 1994;372:786-91 pubmed
    The cytoplasmic focal adhesion protein-tyrosine kinase (FAK) localizes with surface integrin receptors at sites where cells attach to the extracellular matrix...
  33. Lawson C, Lim S, Uryu S, Chen X, Calderwood D, Schlaepfer D. FAK promotes recruitment of talin to nascent adhesions to control cell motility. J Cell Biol. 2012;196:223-32 pubmed publisher
    ..Integrins recruit focal adhesion kinase (FAK) and the cytoskeletal protein talin to nascent adhesions...
  34. Shen T, Park A, Alcaraz A, Peng X, Jang I, Koni P, et al. Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis. J Cell Biol. 2005;169:941-52 pubmed
    Focal adhesion kinase (FAK) is a critical mediator of signal transduction by integrins and growth factor receptors in a variety of cells including endothelial cells (ECs)...
  35. Hagel M, George E, Kim A, Tamimi R, Opitz S, Turner C, et al. The adaptor protein paxillin is essential for normal development in the mouse and is a critical transducer of fibronectin signaling. Mol Cell Biol. 2002;22:901-15 pubmed
    ..display abnormal focal adhesions, reduced cell migration, inefficient localization of focal adhesion kinase (FAK), and reduced fibronectin-induced phosphorylation of FAK, Cas, and mitogen-activated protein kinase...
  36. Kanasaki K, Kanda Y, Palmsten K, Tanjore H, Lee S, LeBleu V, et al. Integrin beta1-mediated matrix assembly and signaling are critical for the normal development and function of the kidney glomerulus. Dev Biol. 2008;313:584-93 pubmed
    ..Collectively, our studies demonstrate that podocyte beta1 integrin and ILK signaling is critical for postnatal development and function of the glomerular filtration apparatus. ..
  37. Ezratty E, Partridge M, Gundersen G. Microtubule-induced focal adhesion disassembly is mediated by dynamin and focal adhesion kinase. Nat Cell Biol. 2005;7:581-90 pubmed
    ..adhesions, and that this disassembly occurs independently of Rho and Rac, but depends on focal adhesion kinase (FAK) and dynamin. During disassembly, dynamin interacts with FAK and colocalizes with focal adhesions...
  38. Park A, Shen T, Chien S, Guan J. Role of focal adhesion kinase Ser-732 phosphorylation in centrosome function during mitosis. J Biol Chem. 2009;284:9418-25 pubmed publisher
    Focal adhesion kinase (FAK) is the major cytoplasmic tyrosine kinase in focal adhesions and a critical mediator of integrin signaling in a variety of cells, including endothelial cells (ECs)...
  39. Chan K, Bennin D, Huttenlocher A. Regulation of adhesion dynamics by calpain-mediated proteolysis of focal adhesion kinase (FAK). J Biol Chem. 2010;285:11418-26 pubmed publisher
    ..regions after Ser-745, resulting in a C-terminal fragment similar in size to the FAK-related non-kinase (FRNK)...
  40. Owen K, Pixley F, Thomas K, Vicente Manzanares M, Ray B, Horwitz A, et al. Regulation of lamellipodial persistence, adhesion turnover, and motility in macrophages by focal adhesion kinase. J Cell Biol. 2007;179:1275-87 pubmed
    ..Macrophages are a key component of the innate immune system. In this study, we investigate how focal adhesion kinase (FAK) and the related kinase Pyk2 integrate adhesion signaling and growth factor receptor signaling to regulate diverse ..
  41. Hanks S, Calalb M, Harper M, Patel S. Focal adhesion protein-tyrosine kinase phosphorylated in response to cell attachment to fibronectin. Proc Natl Acad Sci U S A. 1992;89:8487-91 pubmed
    ..was used to identify a widely expressed protein-tyrosine kinase designated as "focal adhesion kinase" (FadK)...
  42. Hiratsuka S, Goel S, Kamoun W, Maru Y, Fukumura D, Duda D, et al. Endothelial focal adhesion kinase mediates cancer cell homing to discrete regions of the lungs via E-selectin up-regulation. Proc Natl Acad Sci U S A. 2011;108:3725-30 pubmed publisher
    ..This is mediated by endothelial cell-focal adhesion kinase (FAK), which up-regulates E-selectin, leading to preferential homing of metastatic cancer cells to these foci...
  43. Ilic D, Furuta Y, Suda T, Atsumi T, Fujimoto J, Ikawa Y, et al. Focal adhesion kinase is not essential for in vitro and in vivo differentiation of ES cells. Biochem Biophys Res Commun. 1995;209:300-9 pubmed
    Focal adhesion kinase, FAK, is a unique protein tyrosine kinase found in cellular focal adhesions. It is widely expressed and highly phosphorylated during embryogenesis...
  44. Burgaya F, Toutant M, Studler J, Costa A, Le Bert M, Gelman M, et al. Alternatively spliced focal adhesion kinase in rat brain with increased autophosphorylation activity. J Biol Chem. 1997;272:28720-5 pubmed
    pp125 focal adhesion kinase (FAK), a cytoplasmic tyrosine kinase transducing signals initiated by integrin engagement and G protein-coupled receptors, is highly expressed in brain...
  45. Schlaepfer D, Jones K, Hunter T. Multiple Grb2-mediated integrin-stimulated signaling pathways to ERK2/mitogen-activated protein kinase: summation of both c-Src- and focal adhesion kinase-initiated tyrosine phosphorylation events. Mol Cell Biol. 1998;18:2571-85 pubmed
    ..In this study, we show that the nonreceptor protein-tyrosine kinases (PTKs) c-Src and focal adhesion kinase (FAK) can be independently activated after fibronectin (FN) stimulation and that their combined activity promotes ..
  46. Sandilands E, Serrels B, Wilkinson S, Frame M. Src-dependent autophagic degradation of Ret in FAK-signalling-defective cancer cells. EMBO Rep. 2012;13:733-40 pubmed publisher
    We have recently described that autophagic targeting of Src maintains cancer cell viability when FAK signalling is defective...
  47. Palazzo A, Eng C, Schlaepfer D, Marcantonio E, Gundersen G. Localized stabilization of microtubules by integrin- and FAK-facilitated Rho signaling. Science. 2004;303:836-9 pubmed
    ..We report that integrin-mediated activation of focal adhesion kinase (FAK) at the leading edge is required for MT stabilization by the Rho-mDia signaling pathway in mouse fibroblasts...
  48. Lahlou H, Sanguin Gendreau V, Zuo D, Cardiff R, McLean G, Frame M, et al. Mammary epithelial-specific disruption of the focal adhesion kinase blocks mammary tumor progression. Proc Natl Acad Sci U S A. 2007;104:20302-7 pubmed
    Elevated expression and activation of the focal adhesion kinase (FAK) occurs in a large proportion of human breast cancers...
  49. Carter N, Nakamoto T, Hirai H, Hunter T. EphrinA1-induced cytoskeletal re-organization requires FAK and p130(cas). Nat Cell Biol. 2002;4:565-73 pubmed
    ..EphA2, focal adhesion kinase (FAK) and p130(cas) were identified as the major ephrin-dependent phosphotyrosyl proteins during the ephrin-induced ..
  50. Gupta S, Vlahakis N. Integrin alpha9beta1 mediates enhanced cell migration through nitric oxide synthase activity regulated by Src tyrosine kinase. J Cell Sci. 2009;122:2043-54 pubmed publisher
    ..Src appeared to function most proximal in the signaling cascade, in a FAK-independent manner to facilitate iNOS activation and NO-dependent cell migration...
  51. Chan K, Cortesio C, Huttenlocher A. FAK alters invadopodia and focal adhesion composition and dynamics to regulate breast cancer invasion. J Cell Biol. 2009;185:357-70 pubmed publisher
    Focal adhesion kinase (FAK) is important for breast cancer progression and invasion and is necessary for the dynamic turnover of focal adhesions...
  52. Akhtar N, Marlow R, Lambert E, Schatzmann F, Lowe E, Cheung J, et al. Molecular dissection of integrin signalling proteins in the control of mammary epithelial development and differentiation. Development. 2009;136:1019-27 pubmed publisher
    ..of two proximal beta1-integrin signalling intermediates, integrin-linked kinase (ILK) and focal adhesion kinase (FAK)...
  53. Tomar A, Lawson C, Ghassemian M, Schlaepfer D. Cortactin as a target for FAK in the regulation of focal adhesion dynamics. PLoS ONE. 2012;7:e44041 pubmed publisher
    ..Cells without focal adhesion kinase (FAK), an integrin-activated tyrosine kinase, exhibit defects in FA turnover and cell motility...
  54. Sieg D, Ilic D, Jones K, Damsky C, Hunter T, Schlaepfer D. Pyk2 and Src-family protein-tyrosine kinases compensate for the loss of FAK in fibronectin-stimulated signaling events but Pyk2 does not fully function to enhance FAK- cell migration. EMBO J. 1998;17:5933-47 pubmed
    The focal adhesion kinase (FAK) protein-tyrosine kinase (PTK) links transmembrane integrin receptors to intracellular signaling pathways...
  55. Chen B, Tzen J, Bresnick A, Chen H. Roles of Rho-associated kinase and myosin light chain kinase in morphological and migratory defects of focal adhesion kinase-null cells. J Biol Chem. 2002;277:33857-63 pubmed
    Fibroblasts derived from focal adhesion kinase (FAK)-null mouse embryos have a reduced migration rate and an increase in the number and size of peripherally localized adhesions (Ilic, D., Furuta, Y., Kanazawa, S., Takeda, N., Sobue, K...
  56. Ilic D, Mao Qiang M, Crumrine D, Dolganov G, Larocque N, Xu P, et al. Focal adhesion kinase controls pH-dependent epidermal barrier homeostasis by regulating actin-directed Na+/H+ exchanger 1 plasma membrane localization. Am J Pathol. 2007;170:2055-67 pubmed
    Ubiquitously expressed focal adhesion kinase (FAK), linked to multiple intracellular signaling pathways, has previously been shown to control cell motility, invasion, proliferation, and survival...
  57. Xie Z, Sanada K, Samuels B, Shih H, Tsai L. Serine 732 phosphorylation of FAK by Cdk5 is important for microtubule organization, nuclear movement, and neuronal migration. Cell. 2003;114:469-82 pubmed
    ..In nonneuronal cells, the tyrosine kinase FAK is a major regulator of cell motility through focal adhesions...
  58. Sieg D, Hauck C, Schlaepfer D. Required role of focal adhesion kinase (FAK) for integrin-stimulated cell migration. J Cell Sci. 1999;112 ( Pt 16):2677-91 pubmed
    ..Expression of the FAK C-terminal domain, FRNK, promoted FAK dephosphorylation at Tyr-397 and potently blocked FAK-mediated cell migration...
  59. Zhao J, Bian Z, Yee K, Chen B, Chien S, Guan J. Identification of transcription factor KLF8 as a downstream target of focal adhesion kinase in its regulation of cyclin D1 and cell cycle progression. Mol Cell. 2003;11:1503-15 pubmed
    Focal adhesion kinase (FAK) is an important mediator of integrin signaling in the regulation of cell adhesion, migration, survival, and proliferation...
  60. Corsi J, Houbron C, Billuart P, Brunet I, Bouvrée K, Eichmann A, et al. Autophosphorylation-independent and -dependent functions of focal adhesion kinase during development. J Biol Chem. 2009;284:34769-76 pubmed publisher
    Focal adhesion kinase (FAK) regulates numerous cellular functions and is critical for processes ranging from embryo development to cancer progression...
  61. Ashton G, Morton J, Myant K, Phesse T, Ridgway R, Marsh V, et al. Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling. Dev Cell. 2010;19:259-69 pubmed publisher
    ..Here, we show that the integrin effector protein Focal Adhesion Kinase (FAK) is dispensable for normal intestinal homeostasis and DNA damage signaling, but is essential for intestinal ..
  62. Brown M, Cary L, Jamieson J, Cooper J, Turner C. Src and FAK kinases cooperate to phosphorylate paxillin kinase linker, stimulate its focal adhesion localization, and regulate cell spreading and protrusiveness. Mol Biol Cell. 2005;16:4316-28 pubmed
    ..PKL is phosphorylated on tyrosine residues 286/392/592 by Src and/or FAK and these sites are required for PKL localization to focal adhesions and for paxillin binding...
  63. Fan H, Guan J. Compensatory function of Pyk2 protein in the promotion of focal adhesion kinase (FAK)-null mammary cancer stem cell tumorigenicity and metastatic activity. J Biol Chem. 2011;286:18573-82 pubmed publisher
    ..Using a recently developed breast cancer mouse model with focal adhesion kinase (FAK) deletion in mammary tumor cells (MFCKO-MT mice), here we present evidence suggesting a compensatory function of ..
  64. Furuta Y, Ilic D, Kanazawa S, Takeda N, Yamamoto T, Aizawa S. Mesodermal defect in late phase of gastrulation by a targeted mutation of focal adhesion kinase, FAK. Oncogene. 1995;11:1989-95 pubmed
    b>FAK is a unique non-receptor protein tyrosine kinase that was found in cellular focal adhesions...
  65. Weis S, Lim S, Lutu Fuga K, Barnes L, Chen X, Gothert J, et al. Compensatory role for Pyk2 during angiogenesis in adult mice lacking endothelial cell FAK. J Cell Biol. 2008;181:43-50 pubmed publisher
    Focal adhesion kinase (FAK) plays a critical role during vascular development because knockout of FAK in endothelial cells (ECs) is embryonic lethal...
  66. Ilic D, Damsky C, Yamamoto T. Focal adhesion kinase: at the crossroads of signal transduction. J Cell Sci. 1997;110 ( Pt 4):401-7 pubmed
    ..Extensive evidence has shown that the nonreceptor tyrosine kinase, focal adhesion kinase (FAK), is activated in response to both kind of signal...
  67. Hsia D, Mitra S, Hauck C, Streblow D, Nelson J, Ilic D, et al. Differential regulation of cell motility and invasion by FAK. J Cell Biol. 2003;160:753-67 pubmed
    Cell migration and invasion are fundamental components of tumor cell metastasis. Increased focal adhesion kinase (FAK) expression and tyrosine phosphorylation are connected with elevated tumorigenesis...
  68. McLean G, Komiyama N, Serrels B, Asano H, Reynolds L, Conti F, et al. Specific deletion of focal adhesion kinase suppresses tumor formation and blocks malignant progression. Genes Dev. 2004;18:2998-3003 pubmed
    We have generated mice with a floxed fak allele under the control of keratin-14-driven Cre fused to a modified estrogen receptor (CreER(T2))...
  69. Cohen L, Guan J. Residues within the first subdomain of the FERM-like domain in focal adhesion kinase are important in its regulation. J Biol Chem. 2005;280:8197-207 pubmed
    We have previously described regulation of focal adhesion kinase (FAK) by its amino-terminal FERM-like domain through an autoinhibitory interaction with its kinase domain (Cooper, L. A., Shen, T. L., and Guan, J. L. (2003) Mol. Cell...
  70. Tilghman R, Slack Davis J, Sergina N, Martin K, Iwanicki M, Hershey E, et al. Focal adhesion kinase is required for the spatial organization of the leading edge in migrating cells. J Cell Sci. 2005;118:2613-23 pubmed
    ..Focal adhesion kinase (FAK) is intimately involved in the regulation of this process, although the precise mechanism(s) whereby FAK regulates ..
  71. Iwanicki M, Vomastek T, Tilghman R, Martin K, Banerjee J, Wedegaertner P, et al. FAK, PDZ-RhoGEF and ROCKII cooperate to regulate adhesion movement and trailing-edge retraction in fibroblasts. J Cell Sci. 2008;121:895-905 pubmed publisher
    ..Focal adhesion kinase (FAK), guanine nucleotide exchange factors (GEF) for Rho and the Rho effector Rho kinase II (ROCKII) are crucial for the ..
  72. Luo M, Fan H, Nagy T, Wei H, Wang C, Liu S, et al. Mammary epithelial-specific ablation of the focal adhesion kinase suppresses mammary tumorigenesis by affecting mammary cancer stem/progenitor cells. Cancer Res. 2009;69:466-74 pubmed publisher
    Focal adhesion kinase (FAK) has been implicated in the development of cancers, including those of the breast. Nevertheless, the molecular and cellular mechanisms by which FAK promotes mammary tumorigenesis in vivo are not well understood...
  73. Benlimame N, He Q, Jie S, Xiao D, Xu Y, Loignon M, et al. FAK signaling is critical for ErbB-2/ErbB-3 receptor cooperation for oncogenic transformation and invasion. J Cell Biol. 2005;171:505-16 pubmed
    ..We demonstrate that focal adhesion kinase (FAK) is essential for oncogenic transformation and cell invasion that is induced by ErbB-2 and -3 receptor signaling...
  74. Ma H, Togawa A, Soda K, Zhang J, Lee S, Ma M, et al. Inhibition of podocyte FAK protects against proteinuria and foot process effacement. J Am Soc Nephrol. 2010;21:1145-56 pubmed publisher
    Focal adhesion kinase (FAK) is a nonreceptor tyrosine kinase that plays a critical role in cell motility. Movement and retraction of podocyte foot processes, which accompany podocyte injury, suggest focal adhesion disassembly...
  75. Chang F, Lemmon C, Park D, Romer L. FAK potentiates Rac1 activation and localization to matrix adhesion sites: a role for betaPIX. Mol Biol Cell. 2007;18:253-64 pubmed
    b>FAK, a cytoplasmic protein tyrosine kinase, is activated and localized to focal adhesions upon cell attachment to extracellular matrix. FAK null cells spread poorly and exhibit altered focal adhesion turnover...
  76. Li S, Dong W, Zong Y, Yin W, Jin G, Hu Q, et al. Polyethylenimine-complexed plasmid particles targeting focal adhesion kinase function as melanoma tumor therapeutics. Mol Ther. 2007;15:515-23 pubmed
    ..that both plasmid-encoded FAK small interfering RNA (siRNA) and overexpression of FAK-related non-kinase (FRNK, FAK dominant negative) dramatically inhibited in vitro B16F10 cell proliferation and invasion...
  77. Ishibe S, Joly D, Liu Z, Cantley L. Paxillin serves as an ERK-regulated scaffold for coordinating FAK and Rac activation in epithelial morphogenesis. Mol Cell. 2004;16:257-67 pubmed
    ..on serine 83 and that mutation of this site eliminates HGF-stimulated increased association of paxillin and FAK in subconfluent cells...
  78. Kurio N, Shimo T, Fukazawa T, Okui T, Hassan N, Honami T, et al. Anti-tumor effect of a novel FAK inhibitor TAE226 against human oral squamous cell carcinoma. Oral Oncol. 2012;48:1159-70 pubmed publisher
    Focal adhesion kinase (FAK) overexpression is frequently found in invasive and metastatic cancers, but its role in oral squamous cell carcinoma is not yet well understood...
  79. Ilic D, Furuta Y, Kanazawa S, Takeda N, Sobue K, Nakatsuji N, et al. Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice. Nature. 1995;377:539-44 pubmed
    The intracellular protein tyrosine kinase FAK (focal adhesion kinase) was originally identified gy its high level of tyrosine phosphorylation in v-src-transformed cells. FAK is also highly phosphorylated during early development...
  80. Chang L, Huang C, Cheng C, Chen B, Chen H. Differential effect of the focal adhesion kinase Y397F mutant on v-Src-stimulated cell invasion and tumor growth. J Biomed Sci. 2005;12:571-85 pubmed
    Upon cell adhesion to extracellular matrix proteins, focal adhesion kinase (FAK) rapidly undergoes autophosphorylation on its Tyr-397 which consequently serves as a binding site for the Src homology 2 domains of the Src family protein ..
  81. Young S, Hum J, Rodenberg E, Turner C, Pavalko F. Non-overlapping functions for Pyk2 and FAK in osteoblasts during fluid shear stress-induced mechanotransduction. PLoS ONE. 2011;6:e16026 pubmed publisher
    ..Recently, we reported that focal adhesion kinase (FAK) functions as a part of a mechanosome complex that is required for FSS-induced mechanotransduction in bone cells...
  82. Kim J, Leucht P, Luppen C, Park Y, Beggs H, Damsky C, et al. Reconciling the roles of FAK in osteoblast differentiation, osteoclast remodeling, and bone regeneration. Bone. 2007;41:39-51 pubmed
    ..The majority of integrin signaling proceeds through focal adhesion kinase (FAK), an essential component of the focal adhesion complex...
  83. Takeuchi Y, Suzawa M, Kikuchi T, Nishida E, Fujita T, Matsumoto T. Differentiation and transforming growth factor-beta receptor down-regulation by collagen-alpha2beta1 integrin interaction is mediated by focal adhesion kinase and its downstream signals in murine osteoblastic cells. J Biol Chem. 1997;272:29309-16 pubmed
    ..Attachment of cells to COL(I) stimulated tyrosine phosphorylation of focal adhesion kinase (FAK) and extracellular signal-regulated kinase (ERK), a mitogen-activated protein kinase (MAPK), and enhanced MAPK ..
  84. Calalb M, Polte T, Hanks S. Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases. Mol Cell Biol. 1995;15:954-63 pubmed
    Focal adhesion kinase (FAK) is a widely expressed nonreceptor protein-tyrosine kinase implicated in integrin-mediated signal transduction pathways and in the process of oncogenic transformation by v-Src...
  85. Choi C, Webb B, Chimenti M, Jacobson M, Barber D. pH sensing by FAK-His58 regulates focal adhesion remodeling. J Cell Biol. 2013;202:849-59 pubmed publisher
    ..We now report that focal adhesion kinase (FAK), a key regulator of focal adhesion remodeling, is a pH sensor responding to physiological changes in pH...