Pth2r

Summary

Gene Symbol: Pth2r
Description: parathyroid hormone 2 receptor
Alias: Pthr2, parathyroid hormone 2 receptor, PTH2 receptor, parathyroid hormone receptor 2
Species: mouse
Products:     Pth2r

Top Publications

  1. Proctor W, Wu P, Bennett B, Johnson T. Differential effects of ethanol on gamma-aminobutyric acid-A receptor-mediated synaptic currents in congenic strains of inbred long and short-sleep mice. Alcohol Clin Exp Res. 2004;28:1277-83 pubmed
    ..Although the Lore2 and Lore5 QTL regions have a significant effect on sleep time, they do not play a significant role in the differential ethanol enhancement of GABAA IPSCs between ILS and ISS mice. ..
  2. Faber C, Dobolyi A, Sleeman M, Usdin T. Distribution of tuberoinfundibular peptide of 39 residues and its receptor, parathyroid hormone 2 receptor, in the mouse brain. J Comp Neurol. 2007;502:563-83 pubmed
    Tuberoinfundibular peptide of 39 residues (TIP39) was identified as a potent parathyroid hormone 2 receptor (PTH2R) agonist...
  3. Dimitrov E, Kim Y, Usdin T. Regulation of hypothalamic signaling by tuberoinfundibular peptide of 39 residues is critical for the response to cold: a novel peptidergic mechanism of thermoregulation. J Neurosci. 2011;31:18166-79 pubmed publisher
    ..Tuberoinfundibular peptide of 39 residues (TIP39) is a ligand for the parathyroid hormone 2 receptor (PTH2R). Both peptide and receptor are abundant in the preoptic hypothalamus...
  4. Sato E, Zhang L, Dorschner R, Adase C, Choudhury B, Gallo R. Activation of Parathyroid Hormone 2 Receptor Induces Decorin Expression and Promotes Wound Repair. J Invest Dermatol. 2017;137:1774-1783 pubmed publisher
    ..Small interfering RNA-mediated silencing of parathyroid hormone 2 receptor (PTH2R), the receptor for TIP39, suppressed the expression of extracellular matrix-related genes, ..
  5. John M, Arai M, Rubin D, Jonsson K, Juppner H. Identification and characterization of the murine and human gene encoding the tuberoinfundibular peptide of 39 residues. Endocrinology. 2002;143:1047-57 pubmed
    ..Because PTH2 receptor expression was previously shown to be highest in brain, pancreas, and testis, our findings are consistent with ..
  6. Dimitrov E, Petrus E, Usdin T. Tuberoinfundibular peptide of 39 residues (TIP39) signaling modulates acute and tonic nociception. Exp Neurol. 2010;226:68-83 pubmed publisher
    ..the caudal border of the thalamus and in the lateral pons project to areas rich in its receptor, the parathyroid hormone 2 receptor (PTH2R). These areas include many involved in processing nociceptive information...
  7. Atchison D, Harding P, Cecilia Ortiz Capisano M, Peterson E, Beierwaltes W. Parathyroid hormone stimulates juxtaglomerular cell cAMP accumulation without stimulating renin release. Am J Physiol Renal Physiol. 2012;303:F1157-65 pubmed publisher
    Parathyroid hormone (PTH) is positively coupled to the generation of cAMP via its actions on the PTH1R and PTH2R receptors...
  8. Tsuda M, Yeung H, Kuo J, Usdin T. Incubation of Fear Is Regulated by TIP39 Peptide Signaling in the Medial Nucleus of the Amygdala. J Neurosci. 2015;35:12152-61 pubmed publisher
    ..that the neuropeptide tuberoinfundibular peptide of 39 residues (TIP39), via its receptor, the parathyroid hormone 2 receptor (PTH2R), modulates fear memory...
  9. Sato E, Muto J, Zhang L, Adase C, Sanford J, Takahashi T, et al. The Parathyroid Hormone Second Receptor PTH2R and its Ligand Tuberoinfundibular Peptide of 39 Residues TIP39 Regulate Intracellular Calcium and Influence Keratinocyte Differentiation. J Invest Dermatol. 2016;136:1449-1459 pubmed publisher
    ..In this study, we examined the expression and potential functions of the PTH second receptor (PTH2R) and its ligand, the tuberoinfundibular peptide of 39 residues (TIP39), in the skin...

More Information

Publications13

  1. Rubin D, Hellman P, Zon L, Lobb C, Bergwitz C, J ppner H. A G protein-coupled receptor from zebrafish is activated by human parathyroid hormone and not by human or teleost parathyroid hormone-related peptide. Implications for the evolutionary conservation of calcium-regulating peptide hormones. J Biol Chem. 1999;274:23035-42 pubmed
    Genomic and cDNA clones encoding portions of a putative catfish parathyroid hormone (PTH) 2 receptor (PTH2R) led to the isolation of a cDNA encoding a full-length zebrafish PTH2R (zPTH2R)...
  2. Coutellier L, Logemann A, Rusnak M, Usdin T. Maternal absence of the parathyroid hormone 2 receptor affects postnatal pup development. J Neuroendocrinol. 2011;23:612-9 pubmed publisher
    ..suggests that the neuropeptide tuberoinfundibular peptide of 39 residues (TIP39) and its receptor, the parathyroid hormone 2 receptor (PTH2-R), contribute to these mechanisms...
  3. Panda D, Goltzman D, Karaplis A. Defective postnatal endochondral bone development by chondrocyte-specific targeted expression of parathyroid hormone type 2 receptor. Am J Physiol Endocrinol Metab. 2012;303:E1489-501 pubmed publisher
    The human parathyroid hormone type 2 receptor (PTH2R) is activated by PTH and by tuberoinfundibular peptide of 39 residues (TIP39), the latter likely acting as its natural ligand...
  4. Dimitrov E, Kuo J, Kohno K, Usdin T. Neuropathic and inflammatory pain are modulated by tuberoinfundibular peptide of 39 residues. Proc Natl Acad Sci U S A. 2013;110:13156-61 pubmed publisher
    ..These areas are enriched in its receptor, the parathyroid hormone 2 receptor (PTH2R)...