Pth2

Summary

Gene Symbol: Pth2
Description: parathyroid hormone 2
Alias: Tifp39, Tip39, tuberoinfundibular peptide of 39 residues, tuberoinfundibular 39 residue protein, tuberoinfundibular peptide of 39 residues (TIP39) preprohormone
Species: mouse
Products:     Pth2

Top Publications

  1. John M, Arai M, Rubin D, Jonsson K, Juppner H. Identification and characterization of the murine and human gene encoding the tuberoinfundibular peptide of 39 residues. Endocrinology. 2002;143:1047-57 pubmed
    By screening public databases, we identified human and mouse genomic DNA clones that encode the tuberoinfundibular peptide of 39 residues (TIP39)...
  2. Hansen I, Jakob O, Wortmann S, Arzberger T, Allolio B, Blind E. Characterization of the human and mouse genes encoding the tuberoinfundibular peptide of 39 residues, a ligand of the parathyroid hormone receptor family. J Endocrinol. 2002;174:95-102 pubmed
    The polypeptide TIP39 (tuberoinfundibular peptide of 39 residues) is a potent activator of the parathyroid hormone (PTH)-2 receptor (P2R) and an antagonist of the PTH-1 receptor (P1R)...
  3. Faber C, Dobolyi A, Sleeman M, Usdin T. Distribution of tuberoinfundibular peptide of 39 residues and its receptor, parathyroid hormone 2 receptor, in the mouse brain. J Comp Neurol. 2007;502:563-83 pubmed
    b>Tuberoinfundibular peptide of 39 residues (TIP39) was identified as a potent parathyroid hormone 2 receptor (PTH2R) agonist...
  4. Sato E, Muto J, Zhang L, Adase C, Sanford J, Takahashi T, et al. The Parathyroid Hormone Second Receptor PTH2R and its Ligand Tuberoinfundibular Peptide of 39 Residues TIP39 Regulate Intracellular Calcium and Influence Keratinocyte Differentiation. J Invest Dermatol. 2016;136:1449-1459 pubmed publisher
    ..the expression and potential functions of the PTH second receptor (PTH2R) and its ligand, the tuberoinfundibular peptide of 39 residues (TIP39), in the skin...
  5. Dimitrov E, Kuo J, Kohno K, Usdin T. Neuropathic and inflammatory pain are modulated by tuberoinfundibular peptide of 39 residues. Proc Natl Acad Sci U S A. 2013;110:13156-61 pubmed publisher
    ..Neurons that synthesize the neuropeptide TIP39 project to many areas that modulate nociceptive information...
  6. Suzuki T, Li W, Zhang Q, Karim A, Novak E, Sviderskaya E, et al. Hermansky-Pudlak syndrome is caused by mutations in HPS4, the human homolog of the mouse light-ear gene. Nat Genet. 2002;30:321-4 pubmed
    ..In addition, the HPS1 protein is absent in tissues of le mutant mice. These results suggest that the HPS4 and HPS1 proteins may function in the same pathway of organelle biogenesis. ..
  7. Hoare S, Usdin T. Specificity and stability of a new PTH1 receptor antagonist, mouse TIP(7-39). Peptides. 2002;23:989-98 pubmed
    ..6 min (92%), and t(1/2)=21 min (8%)). Loss of unlabeled mTIP(7-39) (250 microg/kg i.v.) receptor binding was similar. mTIP(7-39)'s high-affinity should facilitate animal evaluation of effects of PTH1 receptor antagonism. ..
  8. Della Penna K, Kinose F, Sun H, Koblan K, Wang H. Tuberoinfundibular peptide of 39 residues (TIP39): molecular structure and activity for parathyroid hormone 2 receptor. Neuropharmacology. 2003;44:141-53 pubmed
    The neuropeptide TIP39 was recently purified from bovine hypothalamus based on the ability of the peptide to activate the parathyroid hormone 2 receptor (PTH2R) ( Nat. Neurosci. 2 (1999) 941)...
  9. Valenzuela D, Murphy A, Frendewey D, Gale N, Economides A, Auerbach W, et al. High-throughput engineering of the mouse genome coupled with high-resolution expression analysis. Nat Biotechnol. 2003;21:652-9 pubmed
    ..5-1.0% of the entire genome. We also provide dozens of informative expression patterns involving cells in the nervous system, immune system, vasculature, skeleton, fat and other tissues. ..

More Information

Publications22

  1. Tsuda M, Yeung H, Kuo J, Usdin T. Incubation of Fear Is Regulated by TIP39 Peptide Signaling in the Medial Nucleus of the Amygdala. J Neurosci. 2015;35:12152-61 pubmed publisher
    ..Recent behavioral evidence suggests that the neuropeptide tuberoinfundibular peptide of 39 residues (TIP39), via its receptor, the parathyroid hormone 2 receptor (PTH2R), modulates fear memory...
  2. Coutellier L, Logemann A, Rusnak M, Usdin T. Maternal absence of the parathyroid hormone 2 receptor affects postnatal pup development. J Neuroendocrinol. 2011;23:612-9 pubmed publisher
    ..Recent evidence suggests that the neuropeptide tuberoinfundibular peptide of 39 residues (TIP39) and its receptor, the parathyroid hormone 2 receptor (PTH2-R), contribute to these ..
  3. Sato E, Zhang L, Dorschner R, Adase C, Choudhury B, Gallo R. Activation of Parathyroid Hormone 2 Receptor Induces Decorin Expression and Promotes Wound Repair. J Invest Dermatol. 2017;137:1774-1783 pubmed publisher
    In this study, we report that TIP39, a parathyroid hormone ligand family member that was recently identified to be expressed in the skin, can induce decorin expression and enhance wound repair...
  4. Dobolyi A, Ueda H, Uchida H, Palkovits M, Usdin T. Anatomical and physiological evidence for involvement of tuberoinfundibular peptide of 39 residues in nociception. Proc Natl Acad Sci U S A. 2002;99:1651-6 pubmed
    ..b>Tuberoinfundibular peptide of 39 residues (TIP39) selectively activates the PTH2 receptor...
  5. Zagami C, Stifani S. Molecular characterization of the mouse superior lateral parabrachial nucleus through expression of the transcription factor Runx1. PLoS ONE. 2010;5:e13944 pubmed publisher
    ..Based on the anatomical and molecular characteristics of the Runx1-expressing cells in the rostral hindbrain, we propose that Runx1 expression in this region of the mouse brain defines the superior lateral parabrachial nucleus. ..
  6. Coutellier L, Logemann A, Kuo J, Rusnak M, Usdin T. TIP39 modulates effects of novelty-induced arousal on memory. Genes Brain Behav. 2011;10:90-9 pubmed publisher
    b>Tuberoinfundibular peptide of 39 residues (TIP39) is a neuropeptide localized to neural circuits subserving emotional processing...
  7. Dimitrov E, Petrus E, Usdin T. Tuberoinfundibular peptide of 39 residues (TIP39) signaling modulates acute and tonic nociception. Exp Neurol. 2010;226:68-83 pubmed publisher
    b>Tuberoinfundibular peptide of 39 residues (TIP39) synthesizing neurons at the caudal border of the thalamus and in the lateral pons project to areas rich in its receptor, the parathyroid hormone 2 receptor (PTH2R)...
  8. Usdin T, Paciga M, Riordan T, Kuo J, Parmelee A, Petukova G, et al. Tuberoinfundibular Peptide of 39 residues is required for germ cell development. Endocrinology. 2008;149:4292-300 pubmed publisher
    b>Tuberoinfundibular peptide of 39 residues (TIP39) was identified as a PTH 2 receptor ligand. We report that mice with deletion of Tifp39, the gene encoding TIP39, are sterile...
  9. Dimitrov E, Usdin T. Tuberoinfundibular peptide of 39 residues modulates the mouse hypothalamic-pituitary-adrenal axis via paraventricular glutamatergic neurons. J Comp Neurol. 2010;518:4375-94 pubmed publisher
    ..in the subparafascicular area at the caudal border of the thalamus that contain the neuropeptide tuberoinfundibular peptide of 39 residues (TIP39) densely innervate several hypothalamic areas, including the paraventricular nucleus (PVN)..
  10. Coutellier L, Usdin T. Enhanced long-term fear memory and increased anxiety and depression-like behavior after exposure to an aversive event in mice lacking TIP39 signaling. Behav Brain Res. 2011;222:265-9 pubmed publisher
    ..We hypothesized that tuberoinfundibular-peptide-of-39-residues (TIP39) modulates fear memory by limiting long-term consequences of aversive experiences...
  11. Dimitrov E, Kim Y, Usdin T. Regulation of hypothalamic signaling by tuberoinfundibular peptide of 39 residues is critical for the response to cold: a novel peptidergic mechanism of thermoregulation. J Neurosci. 2011;31:18166-79 pubmed publisher
    ..b>Tuberoinfundibular peptide of 39 residues (TIP39) is a ligand for the parathyroid hormone 2 receptor (PTH2R)...
  12. Panda D, Goltzman D, Juppner H, Karaplis A. TIP39/parathyroid hormone type 2 receptor signaling is a potent inhibitor of chondrocyte proliferation and differentiation. Am J Physiol Endocrinol Metab. 2009;297:E1125-36 pubmed publisher
    b>Tuberoinfundibular peptide of 39 residues (TIP39) is a member of the parathyroid hormone (PTH) family of peptide hormones that exerts its function by interacting with the PTH type 2 receptor (PTH2R)...
  13. Fegley D, Holmes A, Riordan T, Faber C, Weiss J, Ma S, et al. Increased fear- and stress-related anxiety-like behavior in mice lacking tuberoinfundibular peptide of 39 residues. Genes Brain Behav. 2008;7:933-42 pubmed publisher
    b>Tuberoinfundibular peptide of 39 residues (TIP39) is synthesized by two groups of neurons, one in the subparafascicular area at the caudal end of the thalamus and the other in the medial paralemniscal nucleus within the lateral brainstem...