Ptgfr

Summary

Gene Symbol: Ptgfr
Description: prostaglandin F receptor
Alias: AI957154, PGF, prostaglandin F2-alpha receptor, PGF receptor, PGF2-alpha receptor, prostaglandin F2alpha receptor, prostanoid FP receptor
Species: mouse

Top Publications

  1. ncbi Effect of latanoprost on intraocular pressure in mice lacking the prostaglandin FP receptor
    Jonathan G Crowston
    Hamilton Glaucoma Center, Department of Ophthalmology, University of California San Diego, La Jolla, California 92093 0946, USA
    Invest Ophthalmol Vis Sci 45:3555-9. 2004
  2. ncbi Uteroglobin inhibits prostaglandin F2alpha receptor-mediated expression of genes critical for the production of pro-inflammatory lipid mediators
    Asim K Mandal
    Section on Developmental Genetics, Heritable Disorders Branch, NICHD, The National Institutes of Health, Bethesda, Maryland 20892 1830, USA
    J Biol Chem 280:32897-904. 2005
  3. ncbi Prostaglandin FP receptors do not contribute to 24-hour intraocular pressure variation in mice
    Jonathan G Crowston
    Center for Eye Research Australia, Melbourne University, Melbourne, Australia
    Invest Ophthalmol Vis Sci 48:2095-8. 2007
  4. doi Novel suppression mechanism operating in early phase of adipogenesis by positive feedback loop for enhancement of cyclooxygenase-2 expression through prostaglandin F2α receptor mediated activation of MEK/ERK-CREB cascade
    Toshiyuki Ueno
    Laboratory of Biodefense and Regulation, Osaka University of Pharmaceutical Sciences, Japan
    FEBS J 278:2901-12. 2011
  5. doi Prostaglandin F2α receptor silencing attenuates vascular remodeling in rats with type 2 diabetes
    Ya Li
    The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, the State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Ji Nan, PR China Department of Cardiology, Qilu Hospital of Shandong University, Ji Nan, PR China
    Exp Mol Pathol 99:517-23. 2015
  6. ncbi Co-localization of prostaglandin F synthase, cyclooxygenase-1 and prostaglandin F receptor in mouse Leydig cells
    Toshiko Suzuki-Yamamoto
    Department of Anatomy and Cell Biology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3 18 15 Kuramoto, Tokushima, 770 8503, Japan
    Histochem Cell Biol 128:317-22. 2007
  7. pmc Genetic control of resistance to Trypanosoma brucei brucei infection in mice
    Matyáš Síma
    Laboratory of Molecular and Cellular Immunology, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    PLoS Negl Trop Dis 5:e1173. 2011
  8. ncbi Pregnancy and exogenous steroid treatments modulate the expression of relaxant EP(2) and contractile FP receptors in the rat uterus
    Y L Dong
    Department of Obstetrics and Gynecology, The University of Texas Medical Branch, Galveston, Texas 77555, USA
    Biol Reprod 62:533-9. 2000
  9. doi Seizure susceptibility in immature brain due to lack of COX-2-induced PGF2α
    Jee In Chung
    Department of Physiology, Ajou University School of Medicine, Suwon, Republic of Korea Chronic Inflammatory Disease Research Center, Ajou University School of Medicine, Suwon, Republic of Korea
    Exp Neurol 249:95-103. 2013
  10. doi Prostaglandin F2α FP receptor inhibitor reduces demyelination and motor dysfunction in a cuprizone-induced multiple sclerosis mouse model
    K Iwasa
    Department of Pharmacology, Faculty of Medicine, Saitama Medical University, 38 Moro Hongo, Moroyama machi, Iruma gun, Saitama 350 0495, Japan
    Prostaglandins Leukot Essent Fatty Acids 91:175-82. 2014

Research Grants

Scientific Experts

  • STEVEN YELLON
  • Junwu Mu
  • Yukihiko Sugimoto
  • Martyn J James
  • Toshiko Suzuki-Yamamoto
  • Masaki Kawamata
  • Shuh Narumiya
  • Toshiyuki Matsuoka
  • Jonathan G Crowston
  • Daiji Sakata
  • Chengcan Yao
  • Joohwee Kim
  • Ya Li
  • K Iwasa
  • Miyuki Fukuda
  • Evanthia Nikolopoulou
  • Kosuke Akiyama
  • Jee In Chung
  • Koji Takayama
  • Akiyoshi Hara
  • Kenji Kabashima
  • Keisuke Yoshikawa
  • Kitipong Soontrapa
  • Matyáš Síma
  • Toshiyuki Ueno
  • Osamu Saito
  • Takao Shimizu
  • Yoshiyasu Esaki
  • Yoshihiro Kita
  • Laura Popp
  • Kazuhito Tsuboi
  • Toru Oga
  • Sofiyan Saleem
  • S Kunori
  • Ying Yu
  • S Yamamoto
  • James D Lindsey
  • Robert N Weinreb
  • Takayuki Maruyama
  • Yuji Okada
  • Takehiro Yamada
  • Asim K Mandal
  • Richard L Hébert
  • Hideji Karibe
  • Fumitaka Ushikubi
  • Koh Ichi Yuhki
  • Takayuki Fujino
  • A Ichikawa
  • Osamu Takahata
  • Shuhko Kuriyama
  • Youfei Guan
  • Matthew D Breyer
  • Zhonghua Qi
  • Richard M Breyer
  • Carlos Stocco
  • Tadatoshi Muratani
  • Wei Zhang
  • Atsushi Ichikawa
  • Yun Zhang
  • Zhi hao Wang
  • Minsub Shim
  • Ming Zhong
  • S Ito
  • Yi hui Li
  • Meng xiong Tang
  • Yun Ti
  • Lu Han
  • Wen Yuan Ding
  • Michihiro Mutoh
  • K Yoshikawa
  • Mark Christian
  • Susumu Miyamoto
  • Hiroharu Kataoka
  • M Takahashi
  • Akiko Maekawa
  • K Maruyama
  • S Narumiya
  • Malcolm G Parker
  • Georgia Papacleovoulou
  • T Awaji
  • Toshiaki Manabe
  • Giulia Grimaldi
  • Aylin C Hanyaloglu
  • Tomohiro Aoki
  • S Suzuki
  • Takayuki Shirakawa
  • S Yagishita
  • Yasushi Takagi
  • Frédéric Jean-Alphonse
  • Taisuke Kawamoto

Detail Information

Publications48

  1. ncbi Effect of latanoprost on intraocular pressure in mice lacking the prostaglandin FP receptor
    Jonathan G Crowston
    Hamilton Glaucoma Center, Department of Ophthalmology, University of California San Diego, La Jolla, California 92093 0946, USA
    Invest Ophthalmol Vis Sci 45:3555-9. 2004
    ..To determine whether latanoprost lowers IOP in prostaglandin FP receptor knockout mice...
  2. ncbi Uteroglobin inhibits prostaglandin F2alpha receptor-mediated expression of genes critical for the production of pro-inflammatory lipid mediators
    Asim K Mandal
    Section on Developmental Genetics, Heritable Disorders Branch, NICHD, The National Institutes of Health, Bethesda, Maryland 20892 1830, USA
    J Biol Chem 280:32897-904. 2005
    ..We propose that uteroglobin plays important roles in maintaining homeostasis in organs that are vulnerable to inadvertent stimulation of FP-mediated inflammatory response...
  3. ncbi Prostaglandin FP receptors do not contribute to 24-hour intraocular pressure variation in mice
    Jonathan G Crowston
    Center for Eye Research Australia, Melbourne University, Melbourne, Australia
    Invest Ophthalmol Vis Sci 48:2095-8. 2007
    ..The purpose of this study was to compare 24-hour intraocular pressure (IOP) in FP receptor-knockout mice with that of wild-type mice that have normal FP receptor expression...
  4. doi Novel suppression mechanism operating in early phase of adipogenesis by positive feedback loop for enhancement of cyclooxygenase-2 expression through prostaglandin F2α receptor mediated activation of MEK/ERK-CREB cascade
    Toshiyuki Ueno
    Laboratory of Biodefense and Regulation, Osaka University of Pharmaceutical Sciences, Japan
    FEBS J 278:2901-12. 2011
    ..mechanism, operating in the early phase of adipogenesis, that increased the production of anti-adipogenic PGF(2α) and PGE(2) by enhancing cyclooxygenase (COX) 2 expression through the PGF(2α) -activated FP receptor/..
  5. doi Prostaglandin F2α receptor silencing attenuates vascular remodeling in rats with type 2 diabetes
    Ya Li
    The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, the State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Ji Nan, PR China Department of Cardiology, Qilu Hospital of Shandong University, Ji Nan, PR China
    Exp Mol Pathol 99:517-23. 2015
    ..In this study, we aimed to investigate whether the FP receptor is implicated in diabetes-induced vascular remodeling...
  6. ncbi Co-localization of prostaglandin F synthase, cyclooxygenase-1 and prostaglandin F receptor in mouse Leydig cells
    Toshiko Suzuki-Yamamoto
    Department of Anatomy and Cell Biology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3 18 15 Kuramoto, Tokushima, 770 8503, Japan
    Histochem Cell Biol 128:317-22. 2007
    ....
  7. pmc Genetic control of resistance to Trypanosoma brucei brucei infection in mice
    Matyáš Síma
    Laboratory of Molecular and Cellular Immunology, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    PLoS Negl Trop Dis 5:e1173. 2011
    ..Trypanosoma brucei brucei infects livestock, with severe effects in horses and dogs. Mouse strains differ greatly in susceptibility to this parasite. However, no genes controlling these differences were mapped...
  8. ncbi Pregnancy and exogenous steroid treatments modulate the expression of relaxant EP(2) and contractile FP receptors in the rat uterus
    Y L Dong
    Department of Obstetrics and Gynecology, The University of Texas Medical Branch, Galveston, Texas 77555, USA
    Biol Reprod 62:533-9. 2000
    ..Therefore, we conclude that steroid hormones modulate the mRNA for relaxant EP(2) and contractile FP receptors for PGs in the uterus and thus regulate uterine activity during pregnancy and labor...
  9. doi Seizure susceptibility in immature brain due to lack of COX-2-induced PGF2α
    Jee In Chung
    Department of Physiology, Ajou University School of Medicine, Suwon, Republic of Korea Chronic Inflammatory Disease Research Center, Ajou University School of Medicine, Suwon, Republic of Korea
    Exp Neurol 249:95-103. 2013
    ..Taken together, low COX activity and the resulting deficiency of PGF2α may be an essential cause of increased seizure susceptibility in the immature brain...
  10. doi Prostaglandin F2α FP receptor inhibitor reduces demyelination and motor dysfunction in a cuprizone-induced multiple sclerosis mouse model
    K Iwasa
    Department of Pharmacology, Faculty of Medicine, Saitama Medical University, 38 Moro Hongo, Moroyama machi, Iruma gun, Saitama 350 0495, Japan
    Prostaglandins Leukot Essent Fatty Acids 91:175-82. 2014
    Previously, we have demonstrated that prostamide/PGF synthase, which catalyzes the reduction of prostaglandin (PG) H2 to PGF2α, is constitutively expressed in myelin sheaths and cultured oligodendrocytes, suggesting that PGF2α has ..
  11. pmc Arachidonic acid-dependent gene regulation during preadipocyte differentiation controls adipocyte potential
    Evanthia Nikolopoulou
    Institute of Reproductive and Developmental Biology, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK
    J Lipid Res 55:2479-90. 2014
    ..This was mediated by the prostaglandin F(2α) (PGF(2α)), as inhibition of cyclooxygenases or PGF(2α) receptor signaling counteracted the AA-mediated aP2 induction...
  12. ncbi Exacerbation of intracranial aneurysm and aortic dissection in hypertensive rat treated with the prostaglandin F-receptor antagonist AS604872
    Miyuki Fukuda
    Department of Neurosurgery, Medical Innovation Center, Kyoto University Graduate School of Medicine, Japan
    J Pharmacol Sci 126:230-42. 2014
    ....
  13. doi Roles of prostaglandin receptors in female reproduction
    Yukihiko Sugimoto
    Department of Pharmaceutical Biochemistry, Kumamoto University Graduate School of Pharmaceutical Sciences, Oe Honmachi, Kumamoto 862 0973, Japan and CREST, Japan Science and Technology Agency, Saitama 332 0012, Japan Department of Pharmaceutical Biochemistry, Kumamoto University Graduate School of Pharmaceutical Sciences, Oe Honmachi, Kumamoto 862 0973, Japan and CREST, Japan Science and Technology Agency, Saitama 332 0012, Japan
    J Biochem 157:73-80. 2015
    ..A series of studies using FP-deficient mice revealed that PGF(2α)-FP signalling induces parturition at least by terminating progesterone production; however, some other EP ..
  14. pmc Prostaglandin F2α receptor (FP) signaling regulates Bmp signaling and promotes chondrocyte differentiation
    Joohwee Kim
    Department of Biological Sciences, University of South Carolina, Columbia, SC, USA
    Biochim Biophys Acta 1853:500-12. 2015
    ..These results demonstrate that up-regulation of FP expression plays an important role in chondrocyte differentiation and modulates Bmp signaling. ..
  15. doi The F-prostaglandin receptor is a novel marker for tumor endothelial cells in renal cell carcinoma
    Kosuke Akiyama
    Department of Vascular Biology, University of Hokkaido, Sapporo, Japan
    Pathol Int 63:37-44. 2013
    ..Among these genes, the expression levels of prostaglandin F receptor (PTGFR) mRNA, which encodes the prostaglandin F receptor (FP), were higher in TECs than in NECs...
  16. ncbi Different roles of Runx2 during early neural crest-derived bone and tooth development
    Martyn J James
    Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Finland
    J Bone Miner Res 21:1034-44. 2006
    ..In vitro experiments determined that Runx2 is a part of the FGF and BMP signaling pathways in tooth and bone development, respectively...
  17. pmc Parturition and recruitment of macrophages in cervix of mice lacking the prostaglandin F receptor
    Steven M Yellon
    Department of Physiology, Center for Perinatal Biology, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA
    Biol Reprod 78:438-44. 2008
    Parturition does not occur in transgenic mice lacking the prostaglandin F receptor (Ptgfr(-/-)) because luteolysis is forestalled and progesterone production persists...
  18. ncbi Infusion of oxytocin induces successful delivery in prostanoid FP-receptor-deficient mice
    Masaki Kawamata
    Department of Molecular Biology, Graduate School of Agriculture, Tohoku University, Sendai, Miyagi 981 8555, Japan
    Mol Cell Endocrinol 283:32-7. 2008
    ..the most important factor in the induction and accomplishment of parturition since delivery fails in prostaglandin F2alpha receptor (FP) knockout (FP KO) mice...
  19. doi Comparison of nociceptive behavior in prostaglandin E, F, D, prostacyclin and thromboxane receptor knockout mice
    Laura Popp
    Pharmazentrum Frankfurt, ZAFES, Institut fur Klinische Pharmakologie, Klinikum der Johann Wolfgang Goethe Universitat Frankfurt, Theodor Stern Kai 7, Haus 74, Rm 437, 60590 Frankfurt am Main, Germany
    Eur J Pain 13:691-703. 2009
    ....
  20. doi PGF(2alpha) FP receptor contributes to brain damage following transient focal brain ischemia
    Sofiyan Saleem
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, 720 Rutland Ave, Ross 365, Baltimore, MD 21205, USA
    Neurotox Res 15:62-70. 2009
    ..and prostaglandins have been implicated in stroke and excitotoxicity, the role of prostaglandin F(2alpha) (PGF(2alpha)) and its FP receptor have not been elucidated in the pathogenesis of ischemic-reperfusion (I/R) brain ..
  21. pmc Prostaglandin F2alpha elevates blood pressure and promotes atherosclerosis
    Ying Yu
    Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 106:7985-90. 2009
    ..Blockade of the FP offers an approach to the treatment of hypertension and its attendant systemic vascular disease...
  22. pmc Colocalization of prostaglandin F(2alpha) receptor FP and prostaglandin F synthase-I in the spinal cord
    T Suzuki-Yamamoto
    Department of Nutritional Science, Okayama Prefectural University, Soja, Okayama, Japan
    J Lipid Res 50:1996-2003. 2009
    ..These findings suggest that prostaglandin F(2alpha) synthesized in the neuronal somata and dendrites exert an autocrine action there...
  23. doi Involvement of prostaglandin F 2 alpha receptor in ATP-induced mechanical allodynia
    S Kunori
    Department of Medical Chemistry, Kansai Medical University, 10 15 Fumizono, Moriguchi, 570 8506, Osaka, Japan
    Neuroscience 163:362-71. 2009
    ..It has been reported that the intrathecal (i.t.) administration of prostaglandin F(2 alpha) (PGF(2 alpha)) and ATP induces mechanical allodynia via the capsaicin-insensitive primary afferent pathway...
  24. doi Prostaglandin F(2alpha) receptor signaling facilitates bleomycin-induced pulmonary fibrosis independently of transforming growth factor-beta
    Toru Oga
    Department of Pharmacology, Kyoto University Faculty of Medicine, Kyoto, Japan
    Nat Med 15:1426-30. 2009
    ..Here we show that loss of prostaglandin F (PGF) receptor (FP) selectively attenuates pulmonary fibrosis while maintaining similar levels of alveolar inflammation ..
  25. pmc Dual roles of PGE2-EP4 signaling in mouse experimental autoimmune encephalomyelitis
    Yoshiyasu Esaki
    Departments of Pharmacology and Anesthesiology, Faculty of Medicine, Kyoto University, Kyoto 606 8501, Japan
    Proc Natl Acad Sci U S A 107:12233-8. 2010
    ....
  26. doi Preferential localization of prostamide/prostaglandin F synthase in myelin sheaths of the central nervous system
    Keisuke Yoshikawa
    Department of Pathology, Institute for Developmental Research, Aichi Human Service Center, 713 8 Kamiya, Kasugai, Aichi 480 0892, Japan
    Brain Res 1367:22-32. 2011
    ..Although PGF(₂α) is one of the most abundant prostaglandins in the brain, function of PGF(₂α) in the central nervous ..
  27. pmc Prostaglandin E2-prostaglandin E receptor subtype 4 (EP4) signaling mediates UV irradiation-induced systemic immunosuppression
    Kitipong Soontrapa
    Department of Pharmacology, Kyoto University Faculty of Medicine, Kyoto 606 8501, Japan
    Proc Natl Acad Sci U S A 108:6668-73. 2011
    ..Thus, prostaglandin E(2) (PGE(2))-EP4 signaling mediates UV-induced immunosuppression by elevating the number of Treg cells through regulation of RANKL expression in the epidermis...
  28. ncbi Expression of apoptosis in placentae from mice lacking the prostaglandin F receptor
    J Mu
    Department of Obstetrics and Gynecology, Faculty of Medicine, Osaka University, 2 2 Yamadaoka Suita, Osaka, 565 0871 Japan
    Placenta 23:215-23. 2002
    ..Apoptosis may provide insights into both normal placental development and placental dysfunction during an abnormal pregnancy from post-term pregnancy...
  29. ncbi Cloning and expression of a cDNA for mouse prostaglandin F receptor
    Y Sugimoto
    Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Kyoto University, Japan
    J Biol Chem 269:1356-60. 1994
    ..The mouse PGF receptor consists of 366 amino acid residues with putative seven transmembrane domains...
  30. ncbi Mapping of the genes encoding mouse prostaglandin D, E, and F and prostacyclin receptors
    T O Ishikawa
    Banyu Tsukuba Research Institute Merck, Japan
    Genomics 32:285-8. 1996
    ..D receptor gene (Ptgdr), prostaglandin E receptor subtype EP(1) gene (Ptgerepl), prostaglandin F receptor gene (Ptgfr), and prostacyclin receptor gene (Ptgir)...
  31. ncbi Hormonal regulation of prostaglandin F2 alpha receptor gene expression in mouse ovary
    J Sugatani
    Department of Medical Chemistry, Kansai Medical University, Osaka, Japan
    Am J Physiol 271:E686-93. 1996
    ..stimulated the ovary and enhanced the production of progesterone at 1 h PMSG also increased the ovarian PGF2 alpha receptor mRNA level in a time-dependent manner, reaching a sixfold maximum at 1 h...
  32. ncbi Association of expression of mRNA encoding the PGF2 alpha receptor with luteal cell apoptosis in ovaries of pseudopregnant mice
    K Hasumoto
    Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Kyoto University, Japan
    J Reprod Fertil 109:45-51. 1997
    ..No signals for mRNA encoding the PGF2 alpha receptor were detected in the ovary as shown by RNA blot analysis of pregnant mares' serum gonadotrophin (PMSG)-..
  33. ncbi Potential sites of prostaglandin actions in the periimplantation mouse uterus: differential expression and regulation of prostaglandin receptor genes
    Z M Yang
    Department of Physiology, Ralph L Smith Research Center, University of Kansas Medical Center, Kansas City 66160 7336, USA
    Biol Reprod 56:368-79. 1997
    ..In contrast, the expression of these genes during the postimplantation period (Days 5-8) is associated with the onset of decidualization...
  34. ncbi Failure of parturition in mice lacking the prostaglandin F receptor
    Y Sugimoto
    Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Kyoto University, Kyoto 606, Japan
    Science 277:681-3. 1997
    ..These results indicate that parturition is initiated when prostaglandin F2alpha interacts with FP in ovarian luteal cells of the pregnant mice to induce luteolysis...
  35. ncbi Prostanoid receptors: structures, properties, and functions
    S Narumiya
    Department of Pharmacology, Kyoto University Faculty of Medicine, Kyoto, Japan
    Physiol Rev 79:1193-226. 1999
    Prostanoids are the cyclooxygenase metabolites of arachidonic acid and include prostaglandin (PG) D(2), PGE(2), PGF(2alpha), PGI(2), and thromboxne A(2)...
  36. ncbi Uterine expression of prostaglandin H2 synthase in late pregnancy and during parturition in prostaglandin F receptor-deficient mice
    K Tsuboi
    Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Kyoto University, Japan
    Endocrinology 141:315-24. 2000
    ..of the PGH2 synthases, cyclooxygenase-1 (COX-1) and COX-2, in uterine tissues during late pregnancy, using PGF receptor-deficient (FP-/-) mice...
  37. ncbi Involvement of prostaglandin E receptor subtype EP(4) in colon carcinogenesis
    Michihiro Mutoh
    Cancer Prevention Division, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    Cancer Res 62:28-32. 2002
    ....
  38. ncbi Apoptosis and related proteins during parturition in prostaglandin F receptor-deficient mice
    Junwu Mu
    Department of Obstetrics and Gynecology, Radiation Biology, Faculty of Medicine, Osaka University, 2 2 Yamadaoka Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 292:675-81. 2002
    ..These findings demonstrate that apoptosis, Fas, FasL, caspase-3, and Bcl-2 occur in mouse term placenta that is not involved in parturition...
  39. pmc The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut
    Kenji Kabashima
    Department of Pharmacology, Faculty of Medicine, Kyoto University, Kyoto, Japan
    J Clin Invest 109:883-93. 2002
    ..We conclude that EP4 maintains intestinal homeostasis by keeping mucosal integrity and downregulating immune response...
  40. ncbi Identification of a single (FP) receptor associated with prostanoid-induced Ca2+ signals in Swiss 3T3 cells
    D F Woodward
    Department of Biological Sciences, Allergan Inc, Irvine, CA 92713 9534
    Biochem Pharmacol 47:1567-74. 1994
    ..These results support the contention that the FP-receptor has particular sensitivity to PGF2 alpha but will also recognize PGD2 and PGE2...
  41. ncbi Apoptosis and related proteins in placenta of intrauterine fetal death in prostaglandin f receptor-deficient mice
    Junwu Mu
    Department of Obstetrics and Gynecology, Osaka University, Faculty of Medicine, Osaka, Japan
    Biol Reprod 68:1968-74. 2003
    ..Thus, significantly increased apoptosis in the mouse placenta and decidua might be involved in the pathophysiologic mechanism of intrauterine fetal death...
  42. ncbi Role of prostaglandin H2 synthase 2 in murine parturition: study on ovariectomy-induced parturition in prostaglandin F receptor-deficient mice
    Kazuhito Tsuboi
    Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    Biol Reprod 69:195-201. 2003
    ..These findings suggest that COX-2-derived PGs contribute to the onset of parturition after the decrease in serum progesterone level...
  43. ncbi Expression of the prostaglandin F receptor (FP) gene along the mouse genitourinary tract
    Osamu Saito
    Division of Nephrology, Department of Medicine, Vanderbilt University Veterans Affairs Medical Center, Nashville, Tennessee 37212, USA
    Am J Physiol Renal Physiol 284:F1164-70. 2003
    b>PGF(2alpha) is one of the major prostanoids produced by the kidney. The cellular effects of PGF(2alpha) are mediated by a G protein-coupled transmembrane receptor designated the FP receptor...
  44. ncbi Prostaglandin F(2alpha) (PGF(2alpha)) and prolactin signaling: PGF(2alpha)-mediated inhibition of prolactin receptor expression in the Corpus luteum
    Carlos Stocco
    Department of Physiology and Biophysics, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Endocrinology 144:3301-5. 2003
    It is well established that prolactin (PRL) sustains, whereas prostaglandin F(2alpha) (PGF(2alpha)) curtails, progesterone production by the rodent corpus luteum (CL)...
  45. ncbi Functional characterization of prostaglandin F2alpha receptor in the spinal cord for tactile pain (allodynia)
    Tadatoshi Muratani
    Department of Anesthesiology, Osaka Medical College, Takatsuki, Japan
    J Neurochem 86:374-82. 2003
    ..These data strongly suggested that, in the dorsal horn of the spinal cord, there are the FP-expressing cells which are involved in PGF2alpha-induced mechanical allodynia...
  46. ncbi Thromboxane A2 and prostaglandin F2alpha mediate inflammatory tachycardia
    Koji Takayama
    Department of Pharmacology, Asahikawa Medical College, Midorigaoka Higashi 2 1 1 1, Asahikawa 078 8510, Japan
    Nat Med 11:562-6. 2005
    ..Prostanoids, including prostaglandin (PG) D(2), PGE(2), PGF(2alpha), PGI(2) and thromboxane (TX) A(2), exert their actions through specific receptors: DP, EP (EP(1), EP(2), EP(..
  47. ncbi Augmented cardiac hypertrophy in response to pressure overload in mice lacking the prostaglandin I2 receptor
    Akiyoshi Hara
    Department of Pharmacology, Asahikawa Medical College, Midorigaoka Higashi 2 1 1 1, Asahikawa 078 8510, Japan
    Circulation 112:84-92. 2005
    ..However, their roles in cardiac hypertrophy in vivo remain unknown. We intended to clarify the roles of these receptors in pressure overload-induced cardiac hypertrophy using mice lacking each of their receptors...
  48. ncbi Characterization of a rabbit kidney prostaglandin F(2{alpha}) receptor exhibiting G(i)-restricted signaling that inhibits water absorption in the collecting duct
    Richard L Hébert
    Departments of Cellular and Molecular Medicine, Kidney Research Centre, Faculty of Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada
    J Biol Chem 280:35028-37. 2005
    b>PGF(2alpha) is the most abundant prostaglandin detected in urine; however, its renal effects are poorly characterized...

Research Grants1

  1. NEUROENDOCRINE/IMMUNE INTERACTIONS: ROLE OF MELATONIN
    STEVEN YELLON; Fiscal Year: 2002
    ....