Gene Symbol: Ptgfr
Description: prostaglandin F receptor
Alias: AI957154, PGF, prostaglandin F2-alpha receptor, PGF receptor, PGF2-alpha receptor, prostaglandin F2alpha receptor, prostanoid FP receptor
Species: mouse
Products:     Ptgfr

Top Publications

  1. Crowston J, Lindsey J, Aihara M, Weinreb R. Effect of latanoprost on intraocular pressure in mice lacking the prostaglandin FP receptor. Invest Ophthalmol Vis Sci. 2004;45:3555-9 pubmed
    ..52 (-0.91 to -0.14), -1.38 (-2.1 to -0.70), and -1.29 (-1.78 to -0.79) mm Hg, respectively. FP receptor signaling plays a crucial role in the early IOP response to latanoprost in the mouse eye. ..
  2. Mandal A, Ray R, Zhang Z, Chowdhury B, Pattabiraman N, Mukherjee A. Uteroglobin inhibits prostaglandin F2alpha receptor-mediated expression of genes critical for the production of pro-inflammatory lipid mediators. J Biol Chem. 2005;280:32897-904 pubmed
    ..We propose that uteroglobin plays important roles in maintaining homeostasis in organs that are vulnerable to inadvertent stimulation of FP-mediated inflammatory response. ..
  3. Crowston J, Morris C, Lindsey J, Weinreb R. Prostaglandin FP receptors do not contribute to 24-hour intraocular pressure variation in mice. Invest Ophthalmol Vis Sci. 2007;48:2095-8 pubmed
    ..An intact FP receptor does not appear to be critical for normal 24-hour IOP regulation in the mouse eye. ..
  4. Ueno T, Fujimori K. Novel suppression mechanism operating in early phase of adipogenesis by positive feedback loop for enhancement of cyclooxygenase-2 expression through prostaglandin F2? receptor mediated activation of MEK/ERK-CREB cascade. FEBS J. 2011;278:2901-12 pubmed publisher
    ..mechanism, operating in the early phase of adipogenesis, that increased the production of anti-adipogenic PGF(2?) and PGE(2) by enhancing cyclooxygenase (COX) 2 expression through the PGF(2?) -activated FP receptor/..
  5. Chung J, Kim A, Lee S, Baik E. Seizure susceptibility in immature brain due to lack of COX-2-induced PGF2?. Exp Neurol. 2013;249:95-103 pubmed publisher
    ..Taken together, low COX activity and the resulting deficiency of PGF2? may be an essential cause of increased seizure susceptibility in the immature brain. ..
  6. Sugatani J, Masu Y, Nishizawa M, Sakamoto K, Houtani T, Sugimoto T, et al. Hormonal regulation of prostaglandin F2 alpha receptor gene expression in mouse ovary. Am J Physiol. 1996;271:E686-93 pubmed
    ..stimulated the ovary and enhanced the production of progesterone at 1 h PMSG also increased the ovarian PGF2 alpha receptor mRNA level in a time-dependent manner, reaching a sixfold maximum at 1 h...
  7. Sugimoto Y, Yamasaki A, Segi E, Tsuboi K, Aze Y, Nishimura T, et al. Failure of parturition in mice lacking the prostaglandin F receptor. Science. 1997;277:681-3 pubmed
    ..These results indicate that parturition is initiated when prostaglandin F2alpha interacts with FP in ovarian luteal cells of the pregnant mice to induce luteolysis. ..
  8. Saito O, Guan Y, Qi Z, Davis L, Kömhoff M, Sugimoto Y, et al. Expression of the prostaglandin F receptor (FP) gene along the mouse genitourinary tract. Am J Physiol Renal Physiol. 2003;284:F1164-70 pubmed
    b>PGF(2alpha) is one of the major prostanoids produced by the kidney. The cellular effects of PGF(2alpha) are mediated by a G protein-coupled transmembrane receptor designated the FP receptor...
  9. Yoshikawa K, Takei S, Hasegawa Ishii S, Chiba Y, Furukawa A, Kawamura N, et al. Preferential localization of prostamide/prostaglandin F synthase in myelin sheaths of the central nervous system. Brain Res. 2011;1367:22-32 pubmed publisher
    ..Although PGF(??) is one of the most abundant prostaglandins in the brain, function of PGF(??) in the central nervous system (CNS)..

More Information


  1. Yellon S, Ebner C, Sugimoto Y. Parturition and recruitment of macrophages in cervix of mice lacking the prostaglandin F receptor. Biol Reprod. 2008;78:438-44 pubmed
    Parturition does not occur in transgenic mice lacking the prostaglandin F receptor (Ptgfr(-/-)) because luteolysis is forestalled and progesterone production persists...
  2. Fukuda M, Aoki T, Manabe T, Maekawa A, Shirakawa T, Kataoka H, et al. Exacerbation of intracranial aneurysm and aortic dissection in hypertensive rat treated with the prostaglandin F-receptor antagonist AS604872. J Pharmacol Sci. 2014;126:230-42 pubmed
  3. Muratani T, Nishizawa M, Matsumura S, Mabuchi T, Abe K, Shimamoto K, et al. Functional characterization of prostaglandin F2alpha receptor in the spinal cord for tactile pain (allodynia). J Neurochem. 2003;86:374-82 pubmed
    ..These data strongly suggested that, in the dorsal horn of the spinal cord, there are the FP-expressing cells which are involved in PGF2alpha-induced mechanical allodynia. ..
  4. James M, Järvinen E, Wang X, Thesleff I. Different roles of Runx2 during early neural crest-derived bone and tooth development. J Bone Miner Res. 2006;21:1034-44 pubmed
    ..Bone genes were stimulated by BMP4 before the formation of the ossification center, suggesting that BMPs may mediate the early epithelial-mesenchymal interactions involved in bone formation. ..
  5. Tsuboi K, Iwane A, Nakazawa S, Sugimoto Y, Ichikawa A. Role of prostaglandin H2 synthase 2 in murine parturition: study on ovariectomy-induced parturition in prostaglandin F receptor-deficient mice. Biol Reprod. 2003;69:195-201 pubmed
    ..These findings suggest that COX-2-derived PGs contribute to the onset of parturition after the decrease in serum progesterone level. ..
  6. Mu J, Kanzaki T, Si X, Tomimatsu T, Fukuda H, Shioji M, et al. Apoptosis and related proteins in placenta of intrauterine fetal death in prostaglandin f receptor-deficient mice. Biol Reprod. 2003;68:1968-74 pubmed
    ..Thus, significantly increased apoptosis in the mouse placenta and decidua might be involved in the pathophysiologic mechanism of intrauterine fetal death. ..
  7. Soontrapa K, Honda T, Sakata D, Yao C, Hirata T, Hori S, et al. Prostaglandin E2-prostaglandin E receptor subtype 4 (EP4) signaling mediates UV irradiation-induced systemic immunosuppression. Proc Natl Acad Sci U S A. 2011;108:6668-73 pubmed publisher
    ..Thus, prostaglandin E(2) (PGE(2))-EP4 signaling mediates UV-induced immunosuppression by elevating the number of Treg cells through regulation of RANKL expression in the epidermis. ..
  8. Popp L, Häussler A, Olliges A, Nusing R, Narumiya S, Geisslinger G, et al. Comparison of nociceptive behavior in prostaglandin E, F, D, prostacyclin and thromboxane receptor knockout mice. Eur J Pain. 2009;13:691-703 pubmed publisher
  9. Narumiya S, Sugimoto Y, Ushikubi F. Prostanoid receptors: structures, properties, and functions. Physiol Rev. 1999;79:1193-226 pubmed
    Prostanoids are the cyclooxygenase metabolites of arachidonic acid and include prostaglandin (PG) D(2), PGE(2), PGF(2alpha), PGI(2), and thromboxne A(2)...
  10. Yu Y, Lucitt M, Stubbe J, Cheng Y, Friis U, Hansen P, et al. Prostaglandin F2alpha elevates blood pressure and promotes atherosclerosis. Proc Natl Acad Sci U S A. 2009;106:7985-90 pubmed publisher
    ..Blockade of the FP offers an approach to the treatment of hypertension and its attendant systemic vascular disease. ..
  11. Hasumoto K, Sugimoto Y, Yamasaki A, Morimoto K, Kakizuka A, Negishi M, et al. Association of expression of mRNA encoding the PGF2 alpha receptor with luteal cell apoptosis in ovaries of pseudopregnant mice. J Reprod Fertil. 1997;109:45-51 pubmed
    ..No signals for mRNA encoding the PGF2 alpha receptor were detected in the ovary as shown by RNA blot analysis of pregnant mares' serum gonadotrophin (PMSG)-..
  12. Li Y, Han L, Ding W, Ti Y, Li Y, Tang M, et al. Prostaglandin F2? receptor silencing attenuates vascular remodeling in rats with type 2 diabetes. Exp Mol Pathol. 2015;99:517-23 pubmed publisher
    ..Silencing of the FP receptor exerts a protective effect on diabetes-induced vascular remodeling, thereby suggesting a new therapeutic target for vascular remodeling in diabetes. ..
  13. Oga T, Matsuoka T, Yao C, Nonomura K, Kitaoka S, Sakata D, et al. Prostaglandin F(2alpha) receptor signaling facilitates bleomycin-induced pulmonary fibrosis independently of transforming growth factor-beta. Nat Med. 2009;15:1426-30 pubmed publisher
    ..Here we show that loss of prostaglandin F (PGF) receptor (FP) selectively attenuates pulmonary fibrosis while maintaining similar levels of alveolar inflammation ..
  14. Kunori S, Matsumura S, Mabuchi T, Tatsumi S, Sugimoto Y, Minami T, et al. Involvement of prostaglandin F 2 alpha receptor in ATP-induced mechanical allodynia. Neuroscience. 2009;163:362-71 pubmed publisher
    ..It has been reported that the intrathecal (i.t.) administration of prostaglandin F(2 alpha) (PGF(2 alpha)) and ATP induces mechanical allodynia via the capsaicin-insensitive primary afferent pathway...
  15. Hara A, Yuhki K, Fujino T, Yamada T, Takayama K, Kuriyama S, et al. Augmented cardiac hypertrophy in response to pressure overload in mice lacking the prostaglandin I2 receptor. Circulation. 2005;112:84-92 pubmed
    ..Both effects have been suggested as originating from the action on noncardiomyocytes rather than cardiomyocytes. ..
  16. Iwasa K, Yamamoto S, Takahashi M, Suzuki S, Yagishita S, Awaji T, et al. Prostaglandin F2α FP receptor inhibitor reduces demyelination and motor dysfunction in a cuprizone-induced multiple sclerosis mouse model. Prostaglandins Leukot Essent Fatty Acids. 2014;91:175-82 pubmed publisher
    Previously, we have demonstrated that prostamide/PGF synthase, which catalyzes the reduction of prostaglandin (PG) H2 to PGF2α, is constitutively expressed in myelin sheaths and cultured oligodendrocytes, suggesting that PGF2α has ..
  17. Sugimoto Y, Inazumi T, Tsuchiya S. Roles of prostaglandin receptors in female reproduction. J Biochem. 2015;157:73-80 pubmed publisher
    ..A series of studies using FP-deficient mice revealed that PGF(2α)-FP signalling induces parturition at least by terminating progesterone production; however, some other EP ..
  18. Tsuboi K, Sugimoto Y, Iwane A, Yamamoto K, Yamamoto S, Ichikawa A. Uterine expression of prostaglandin H2 synthase in late pregnancy and during parturition in prostaglandin F receptor-deficient mice. Endocrinology. 2000;141:315-24 pubmed
    ..of the PGH2 synthases, cyclooxygenase-1 (COX-1) and COX-2, in uterine tissues during late pregnancy, using PGF receptor-deficient (FP-/-) mice...
  19. Ishikawa T, Tamai Y, Rochelle J, Hirata M, Namba T, Sugimoto Y, et al. Mapping of the genes encoding mouse prostaglandin D, E, and F and prostacyclin receptors. Genomics. 1996;32:285-8 pubmed
    ..D receptor gene (Ptgdr), prostaglandin E receptor subtype EP(1) gene (Ptgerepl), prostaglandin F receptor gene (Ptgfr), and prostacyclin receptor gene (Ptgir)...
  20. Takayama K, Yuhki K, Ono K, Fujino T, Hara A, Yamada T, et al. Thromboxane A2 and prostaglandin F2alpha mediate inflammatory tachycardia. Nat Med. 2005;11:562-6 pubmed
    ..Prostanoids, including prostaglandin (PG) D(2), PGE(2), PGF(2alpha), PGI(2) and thromboxane (TX) A(2), exert their actions through specific receptors: DP, EP (EP(1), EP(2), EP(..
  21. Hébert R, Carmosino M, Saito O, Yang G, Jackson C, Qi Z, et al. Characterization of a rabbit kidney prostaglandin F(2{alpha}) receptor exhibiting G(i)-restricted signaling that inhibits water absorption in the collecting duct. J Biol Chem. 2005;280:35028-37 pubmed
    b>PGF(2alpha) is the most abundant prostaglandin detected in urine; however, its renal effects are poorly characterized...
  22. Stocco C, Djiane J, Gibori G. Prostaglandin F(2alpha) (PGF(2alpha)) and prolactin signaling: PGF(2alpha)-mediated inhibition of prolactin receptor expression in the Corpus luteum. Endocrinology. 2003;144:3301-5 pubmed
    It is well established that prolactin (PRL) sustains, whereas prostaglandin F(2alpha) (PGF(2alpha)) curtails, progesterone production by the rodent corpus luteum (CL)...
  23. Mu J, Kanzaki T, Tomimatsu T, Fukuda H, Wasada K, Fujii E, et al. Expression of apoptosis in placentae from mice lacking the prostaglandin F receptor. Placenta. 2002;23:215-23 pubmed
    ..Apoptosis may provide insights into both normal placental development and placental dysfunction during an abnormal pregnancy from post-term pregnancy. ..
  24. Mu J, Kanzaki T, Si X, Tomimatsu T, Fukuda H, Fujii E, et al. Apoptosis and related proteins during parturition in prostaglandin F receptor-deficient mice. Biochem Biophys Res Commun. 2002;292:675-81 pubmed
    ..These findings demonstrate that apoptosis, Fas, FasL, caspase-3, and Bcl-2 occur in mouse term placenta that is not involved in parturition. ..
  25. Síma M, Havelková H, Quan L, Svobodova M, Jarošíková T, Vojtísková J, et al. Genetic control of resistance to Trypanosoma brucei brucei infection in mice. PLoS Negl Trop Dis. 2011;5:e1173 pubmed publisher
    ..Definition of susceptibility genes will improve the understanding of pathways and genetic diversity underlying the disease and may result in new strategies to overcome the active subversion of the immune system by T. b. brucei. ..
  26. Kim J, Shim M. Prostaglandin F2α receptor (FP) signaling regulates Bmp signaling and promotes chondrocyte differentiation. Biochim Biophys Acta. 2015;1853:500-12 pubmed publisher
    ..These results demonstrate that up-regulation of FP expression plays an important role in chondrocyte differentiation and modulates Bmp signaling. ..
  27. Esaki Y, Li Y, Sakata D, Yao C, Segi Nishida E, Matsuoka T, et al. Dual roles of PGE2-EP4 signaling in mouse experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A. 2010;107:12233-8 pubmed publisher
  28. Inoue K, Hirose M, Inoue H, Hatanaka Y, Honda A, Hasegawa A, et al. The Rodent-Specific MicroRNA Cluster within the Sfmbt2 Gene Is Imprinted and Essential for Placental Development. Cell Rep. 2017;19:949-956 pubmed publisher
    ..Our study has provided experimental evidence for the indispensable roles of placental miRNAs in trophoblast proliferation and thus fetal development. ..
  29. Kawamata M, Yoshida M, Sugimoto Y, Kimura T, Tonomura Y, Takayanagi Y, et al. Infusion of oxytocin induces successful delivery in prostanoid FP-receptor-deficient mice. Mol Cell Endocrinol. 2008;283:32-7 pubmed
    ..the most important factor in the induction and accomplishment of parturition since delivery fails in prostaglandin F2alpha receptor (FP) knockout (FP KO) mice...
  30. Kabashima K, Saji T, Murata T, Nagamachi M, Matsuoka T, Segi E, et al. The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut. J Clin Invest. 2002;109:883-93 pubmed
    ..We conclude that EP4 maintains intestinal homeostasis by keeping mucosal integrity and downregulating immune response. ..
  31. Yang Z, Das S, Wang J, Sugimoto Y, Ichikawa A, Dey S. Potential sites of prostaglandin actions in the periimplantation mouse uterus: differential expression and regulation of prostaglandin receptor genes. Biol Reprod. 1997;56:368-79 pubmed
    ..In contrast, the expression of these genes during the postimplantation period (Days 5-8) is associated with the onset of decidualization. ..
  32. Suzuki Yamamoto T, Toida K, Sugimoto Y, Ishimura K. Colocalization of prostaglandin F(2alpha) receptor FP and prostaglandin F synthase-I in the spinal cord. J Lipid Res. 2009;50:1996-2003 pubmed publisher
    ..These findings suggest that prostaglandin F(2alpha) synthesized in the neuronal somata and dendrites exert an autocrine action there. ..
  33. Saleem S, Ahmad A, Maruyama T, Narumiya S, DORE S. PGF(2alpha) FP receptor contributes to brain damage following transient focal brain ischemia. Neurotox Res. 2009;15:62-70 pubmed publisher
    ..and prostaglandins have been implicated in stroke and excitotoxicity, the role of prostaglandin F(2alpha) (PGF(2alpha)) and its FP receptor have not been elucidated in the pathogenesis of ischemic-reperfusion (I/R) brain ..
  34. Suzuki Yamamoto T, Sugimoto Y, Ichikawa A, Ishimura K. Co-localization of prostaglandin F synthase, cyclooxygenase-1 and prostaglandin F receptor in mouse Leydig cells. Histochem Cell Biol. 2007;128:317-22 pubmed
  35. Akiyama K, Ohga N, Maishi N, Hida Y, Kitayama K, Kawamoto T, et al. The F-prostaglandin receptor is a novel marker for tumor endothelial cells in renal cell carcinoma. Pathol Int. 2013;63:37-44 pubmed publisher
    ..Among these genes, the expression levels of prostaglandin F receptor (PTGFR) mRNA, which encodes the prostaglandin F receptor (FP), were higher in TECs than in NECs...
  36. Nikolopoulou E, Papacleovoulou G, Jean Alphonse F, Grimaldi G, Parker M, Hanyaloglu A, et al. Arachidonic acid-dependent gene regulation during preadipocyte differentiation controls adipocyte potential. J Lipid Res. 2014;55:2479-90 pubmed publisher
    ..This was mediated by the prostaglandin F(2α) (PGF(2α)), as inhibition of cyclooxygenases or PGF(2α) receptor signaling counteracted the AA-mediated aP2 ..
  37. Mutoh M, Watanabe K, Kitamura T, Shoji Y, Takahashi M, Kawamori T, et al. Involvement of prostaglandin E receptor subtype EP(4) in colon carcinogenesis. Cancer Res. 2002;62:28-32 pubmed
  38. Sugimoto Y, Hasumoto K, Namba T, Irie A, Katsuyama M, Negishi M, et al. Cloning and expression of a cDNA for mouse prostaglandin F receptor. J Biol Chem. 1994;269:1356-60 pubmed
    ..The mouse PGF receptor consists of 366 amino acid residues with putative seven transmembrane domains...
  39. Woodward D, Lawrence R. Identification of a single (FP) receptor associated with prostanoid-induced Ca2+ signals in Swiss 3T3 cells. Biochem Pharmacol. 1994;47:1567-74 pubmed
    ..These results support the contention that the FP-receptor has particular sensitivity to PGF2 alpha but will also recognize PGD2 and PGE2. ..
  40. Dong Y, Yallampalli C. Pregnancy and exogenous steroid treatments modulate the expression of relaxant EP(2) and contractile FP receptors in the rat uterus. Biol Reprod. 2000;62:533-9 pubmed
    ..Therefore, we conclude that steroid hormones modulate the mRNA for relaxant EP(2) and contractile FP receptors for PGs in the uterus and thus regulate uterine activity during pregnancy and labor. ..