Gene Symbol: Ptges3
Description: prostaglandin E synthase 3
Alias: 5730442A20Rik, Ptges, Tebp, cPGES, p23, sid3177, prostaglandin E synthase 3, cytosolic prostaglandin E2 synthase, hsp90 co-chaperone, p23 cochaperone, progesterone receptor complex p23, prostaglandin E synthase 3 (cytosolic), sid 3177, telomerase binding protein, p23
Species: mouse
Products:     Ptges3

Top Publications

  1. Grad I, McKee T, Ludwig S, Hoyle G, Ruiz P, Wurst W, et al. The Hsp90 cochaperone p23 is essential for perinatal survival. Mol Cell Biol. 2006;26:8976-83 pubmed
    ..that is thought to stabilize Hsp90-substrate complexes and, independently, to act as the cytosolic prostaglandin E2 synthase. Gene deletions in budding and fission yeasts and knock-down experiments with the worm have not ..
  2. Lovgren A, Kovarova M, Koller B. cPGES/p23 is required for glucocorticoid receptor function and embryonic growth but not prostaglandin E2 synthesis. Mol Cell Biol. 2007;27:4416-30 pubmed
    A number of studies have identified cytosolic prostaglandin E(2) synthase (cPGES)/p23 as a cytoplasmic protein capable of metabolism of prostaglandin E(2) (PGE(2)) from the cyclooxygenase metabolite prostaglandin endoperoxide (PGH(2))...
  3. Walsh J, Cullen S, Sheridan C, Lüthi A, Gerner C, Martin S. Executioner caspase-3 and caspase-7 are functionally distinct proteases. Proc Natl Acad Sci U S A. 2008;105:12815-9 pubmed publisher
    ..differential activity toward multiple substrate proteins, including Bid, XIAP, gelsolin, caspase-6, and cochaperone p23. Caspase-3 was found to be generally more promiscuous than caspase-7 and appears to be the major executioner ..
  4. Zhang J, Spilman P, Chen S, Gorostiza O, Matalis A, Niazi K, et al. The small co-chaperone p23 overexpressing transgenic mouse. J Neurosci Methods. 2013;212:190-4 pubmed publisher
    ..Earlier, we described the role of p23 a small co-chaperone protein in preventing ER stress-induced cell death...
  5. Zhang X, Verdine G. Mammalian DNA cytosine-5 methyltransferase interacts with p23 protein. FEBS Lett. 1996;392:179-83 pubmed
    ..Here we report an interaction between the C-terminal catalytic domain of the MTase and p23, a protein previously reported to associate with the progesterone receptor (PR) complex.
  6. Zhang Y, Schneider A, Rao R, Lu W, Fan X, Davis L, et al. Genomic structure and genitourinary expression of mouse cytosolic prostaglandin E(2) synthase gene. Biochim Biophys Acta. 2003;1634:15-23 pubmed
    ..Here we report the genomic structure and tissue-selective expression of cytosolic PGE(2) synthase (cPGES) in genitourinary tissues...
  7. Bush J, Lan Y, Jiang R. The cleft lip and palate defects in Dancer mutant mice result from gain of function of the Tbx10 gene. Proc Natl Acad Sci U S A. 2004;101:7022-7 pubmed
    ..Positional cloning of the Dc locus revealed an insertion of a 3.3-kb sequence containing the 5' region of the p23 gene into the first intron of Tbx10, which causes ectopic expression of a p23-Tbx10 chimeric transcript encoding a ..
  8. Poksay K, Banwait S, Crippen D, Mao X, Bredesen D, Rao R. The small chaperone protein p23 and its cleaved product p19 in cellular stress. J Mol Neurosci. 2012;46:303-14 pubmed publisher
    ..Earlier, we reported the role of the small co-chaperone protein p23 in preventing ER stress-induced cell death...
  9. Liepelt A, Naarmann de Vries I, Simons N, Eichelbaum K, Föhr S, Archer S, et al. Identification of RNA-binding Proteins in Macrophages by Interactome Capture. Mol Cell Proteomics. 2016;15:2699-714 pubmed publisher
    ..From this group, we validated the HSP90 cochaperone P23 that was demonstrated to exhibit cytosolic prostaglandin E2 synthase 3 (PTGES3) activity, and the hematopoietic cell-specific LYN substrate 1 (HCLS1 or HS1), a ..

More Information


  1. Cullen S, Adrain C, Lüthi A, Duriez P, Martin S. Human and murine granzyme B exhibit divergent substrate preferences. J Cell Biol. 2007;176:435-44 pubmed
    ..These data demonstrate that human and murine GzmB are distinct enzymes with different substrate preferences. Our observations also illustrate how subtle differences in enzyme structure can radically affect substrate selection. ..
  2. Nakatani Y, Hokonohara Y, Kakuta S, Sudo K, Iwakura Y, Kudo I. Knockout mice lacking cPGES/p23, a constitutively expressed PGE2 synthetic enzyme, are peri-natally lethal. Biochem Biophys Res Commun. 2007;362:387-92 pubmed
    Cytosolic prostaglandin (PG) E synthase (cPGES) is constitutively expressed in various cells and regulates cyclooxygenase (COX)-1-dependent immediate PGE(2) generation...
  3. Ge X, Rameix Welti M, Gault E, Chase G, Dos Santos Afonso E, Picard D, et al. Influenza virus infection induces the nuclear relocalization of the Hsp90 co-chaperone p23 and inhibits the glucocorticoid receptor response. PLoS ONE. 2011;6:e23368 pubmed publisher
    ..Here we report that the p23 cochaperone of Hsp90, which plays a major role in glucocorticoid receptor folding and function, associates with influenza ..
  4. Zelin E, Zhang Y, Toogun O, Zhong S, Freeman B. The p23 molecular chaperone and GCN5 acetylase jointly modulate protein-DNA dynamics and open chromatin status. Mol Cell. 2012;48:459-70 pubmed publisher
    ..Here we show that the p23 molecular chaperone initiates disassembly of protein-DNA complexes and that the GCN5 acetyltransferase prolongs the ..
  5. Nguyen P, Wang D, Wang Y, Li Y, Uchizono J, Chan W. p23 co-chaperone protects the aryl hydrocarbon receptor from degradation in mouse and human cell lines. Biochem Pharmacol. 2012;84:838-50 pubmed publisher
    ..Without ligand, the AhR complex is cytoplasmic and contains p23. Our objective was to investigate whether the wild type p23 levels are important for the AhR function...
  6. Vogel S, Raulf N, Bregenhorn S, Biniossek M, Maurer U, Czabotar P, et al. Cytosolic Bax: does it require binding proteins to keep its pro-apoptotic activity in check?. J Biol Chem. 2012;287:9112-27 pubmed publisher
    ..purification by gel filtration and blue native gel electrophoresis, we detected only one protein, called p23 hsp90 co-chaperone, which consistently and specifically co-purified with Bax...
  7. Nakatani Y, Hokonohara Y, Tajima Y, Kudo I, Hara S. Involvement of the constitutive prostaglandin E synthase cPGES/p23 in expression of an initial prostaglandin E2 inactivating enzyme, 15-PGDH. Prostaglandins Other Lipid Mediat. 2011;94:112-7 pubmed publisher
    We previously showed that cytosolic prostaglandin (PG) E synthase (cPGES/p23) which isomerizes PGH(2) to PGE(2), is essential for fetal mouse development...
  8. Lee J, Kim H, Moon J, Sung Y, Baek I, Roh J, et al. Transgenic overexpression of p23 induces spontaneous hydronephrosis in mice. Int J Exp Pathol. 2011;92:251-9 pubmed publisher
    b>p23 is a cochaperone of heat shock protein 90 and also interacts functionally with numerous steroid receptors and kinases. However, the in vivo roles of p23 remain unclear...
  9. Forafonov F, Toogun O, Grad I, Suslova E, Freeman B, Picard D. p23/Sba1p protects against Hsp90 inhibitors independently of its intrinsic chaperone activity. Mol Cell Biol. 2008;28:3446-56 pubmed publisher
    ..Unlike the biochemical activities of the cochaperone p23, its in vivo functions and the structure-function relationship remain poorly understood, even in the genetically ..
  10. Madon Simon M, Grad I, Bayo P, Perez P, Picard D. Defective glucocorticoid receptor signaling and keratinocyte-autonomous defects contribute to skin phenotype of mouse embryos lacking the Hsp90 co-chaperone p23. PLoS ONE. 2017;12:e0180035 pubmed publisher
    b>p23 is a small acidic protein with intrinsic molecular chaperone activity. It is best known as a co-chaperone of the major cytosolic molecular chaperone Hsp90...
  11. Baldo B, Weiss A, Parker C, Bibel M, Paganetti P, Kaupmann K. A screen for enhancers of clearance identifies huntingtin as a heat shock protein 90 (Hsp90) client protein. J Biol Chem. 2012;287:1406-14 pubmed publisher
    ..Hsp90 inhibition disrupted the interaction and induced clearance of Htt through the ubiquitin-proteasome system. Our data suggest that Htt is an Hsp90 client protein and that Hsp90 inhibition may provide a means to reduce mHtt in HD. ..
  12. Jin W, Dai J, Zhou H, Xia Q, Zou H, Zeng R. Phosphoproteome analysis of mouse liver using immobilized metal affinity purification and linear ion trap mass spectrometry. Rapid Commun Mass Spectrom. 2004;18:2169-76 pubmed
    ..The use of the linear ion trap considerably enabled exploitation of nanoflow-HPLC/MS/MS, and in addition MS/MS/MS has great potential in phosphoproteome research of relatively complex samples. ..
  13. Holt S, Aisner D, Baur J, Tesmer V, Dy M, Ouellette M, et al. Functional requirement of p23 and Hsp90 in telomerase complexes. Genes Dev. 1999;13:817-26 pubmed
    ..We have identified the molecular chaperones p23 and Hsp90 as proteins that bind to the catalytic subunit of telomerase...