Gene Symbol: Ptges2
Description: prostaglandin E synthase 2
Alias: 0610038H10Rik, C79137, Gbf1, Mpges2, Pges2, prostaglandin E synthase 2, GATE-binding factor 1, mPGES-2, microsomal prostaglandin E synthase 2
Species: mouse
Products:     Ptges2

Top Publications

  1. Murakami M, Nakashima K, Kamei D, Masuda S, Ishikawa Y, Ishii T, et al. Cellular prostaglandin E2 production by membrane-bound prostaglandin E synthase-2 via both cyclooxygenases-1 and -2. J Biol Chem. 2003;278:37937-47 pubmed
    ..Collectively, mPGES-2 is a unique PGES that can be coupled with both COXs and may play a role in the production of the PGE2 involved in both tissue homeostasis and disease. ..
  2. Sun Y, Jia Z, Yang G, Kakizoe Y, Liu M, Yang K, et al. mPGES-2 deletion remarkably enhances liver injury in streptozotocin-treated mice via induction of GLUT2. J Hepatol. 2014;61:1328-1336 pubmed publisher
    ..mPGES-2 deletion enhanced STZ-induced liver toxicity possibly via GLUT2-mediated STZ uptake, independently of diabetes mellitus. ..
  3. Leppilampi M, Parkkila S, Karttunen T, Gut M, Gros G, Sjöblom M. Carbonic anhydrase isozyme-II-deficient mice lack the duodenal bicarbonate secretory response to prostaglandin E2. Proc Natl Acad Sci U S A. 2005;102:15247-52 pubmed
    ..Our data demonstrate a gastrointestinal phenotypic abnormality associated with CA II deficiency. The results show that the stimulatory effect of the duodenal secretagogue PGE2 completely depends on CA II. ..
  4. Yang G, Chen L, Zhang Y, Zhang X, Wu J, Li S, et al. Expression of mouse membrane-associated prostaglandin E2 synthase-2 (mPGES-2) along the urogenital tract. Biochim Biophys Acta. 2006;1761:1459-68 pubmed
    ..This expression pattern is consistent with an important role for mPGES-2-mediated PGE(2) in urogenital function. ..
  5. Matysiak M, Fortak Michalska M, Szymanska B, Orlowski W, Jurewicz A, Selmaj K. MicroRNA-146a negatively regulates the immunoregulatory activity of bone marrow stem cells by targeting prostaglandin E2 synthase-2. J Immunol. 2013;190:5102-9 pubmed publisher
    ..Accordingly, inhibition of miR-146a restored synthesis of PGE2. These data support the conclusion that miR-146a plays a critical role in the control of the immunoregulatory potential of BMSCs. ..
  6. Engblom D, Saha S, Engström L, Westman M, Audoly L, Jakobsson P, et al. Microsomal prostaglandin E synthase-1 is the central switch during immune-induced pyresis. Nat Neurosci. 2003;6:1137-8 pubmed
    ..Our findings identify mPGES-1 as the central switch during immune-induced pyresis and as a target for the treatment of fever and other PGE2-dependent acute phase reactions elicited by the brain. ..
  7. Ma X, Aoki T, Tsuruyama T, Narumiya S. Definition of Prostaglandin E2-EP2 Signals in the Colon Tumor Microenvironment That Amplify Inflammation and Tumor Growth. Cancer Res. 2015;75:2822-32 pubmed publisher
  8. Chandrasekharan S, Foley N, Jania L, Clark P, Audoly L, Koller B. Coupling of COX-1 to mPGES1 for prostaglandin E2 biosynthesis in the murine mammary gland. J Lipid Res. 2005;46:2636-48 pubmed
    ..COX-1 and COX-2) and three terminal PGE synthases: microsomal prostaglandin E2 synthase-1 (mPGES1), mPGES2, and cytosolic prostaglandin E2 synthase (cPGES)...
  9. Hu J, Meng Q, Roy S, Raha A, Hu J, Zhang J, et al. A novel transactivating factor that regulates interferon-gamma-dependent gene expression. J Biol Chem. 2002;277:30253-63 pubmed
    ..Its expression is induced by IFN-gamma treatment. GBF-1 is present in both cytosolic and nuclear compartments. These studies thus identify a novel transactivating factor in IFN signaling pathways. ..

More Information


  1. Oshima H, Oguma K, Du Y, Oshima M. Prostaglandin E2, Wnt, and BMP in gastric tumor mouse models. Cancer Sci. 2009;100:1779-85 pubmed publisher
  2. Lundequist A, Nallamshetty S, Xing W, Feng C, Laidlaw T, Uematsu S, et al. Prostaglandin E(2) exerts homeostatic regulation of pulmonary vascular remodeling in allergic airway inflammation. J Immunol. 2010;184:433-41 pubmed publisher
    ..Thus, mPGES-1 and its product, PGE(2), protect the pulmonary vasculature from remodeling during allergen-induced pulmonary inflammation, and these effects may be mediated by more than one EP receptor. ..
  3. Radi Z, Ostroski R. Pulmonary and cardiorenal cyclooxygenase-1 (COX-1), -2 (COX-2), and microsomal prostaglandin E synthase-1 (mPGES-1) and -2 (mPGES-2) expression in a hypertension model. Mediators Inflamm. 2007;2007:85091 pubmed
  4. Facemire C, Nguyen M, Jania L, Beierwaltes W, Kim H, Koller B, et al. A major role for the EP4 receptor in regulation of renin. Am J Physiol Renal Physiol. 2011;301:F1035-41 pubmed publisher
    ..with targeted disruption of several key genes: cyclooxygenase-2 (COX-2), microsomal PGE synthases 1 and 2 (mPGES1, mPGES2), EP2 and EP4 receptors for PGE(2), and the IP receptor for PGI(2)...
  5. Jania L, Chandrasekharan S, Backlund M, Foley N, Snouwaert J, Wang I, et al. Microsomal prostaglandin E synthase-2 is not essential for in vivo prostaglandin E2 biosynthesis. Prostaglandins Other Lipid Mediat. 2009;88:73-81 pubmed publisher
    ..Taken together, analysis of the mPGES-2 deficient mouse lines does not substantiate the contention that mPGES-2 is a PGE(2) synthase. ..
  6. Meng Q, Raha A, Roy S, Hu J, Kalvakolanu D. IFN-gamma-stimulated transcriptional activation by IFN-gamma-activated transcriptional element-binding factor 1 occurs via an inducible interaction with CAAAT/enhancer-binding protein-beta. J Immunol. 2005;174:6203-11 pubmed
    IFN-gamma-activated transcriptional element (GATE)-binding factor 1 (GBF1) was identified as a transactivator that induces gene expression through GATE, a novel IFN-inducible element...
  7. Bosetti F, Langenbach R, Weerasinghe G. Prostaglandin E2 and microsomal prostaglandin E synthase-2 expression are decreased in the cyclooxygenase-2-deficient mouse brain despite compensatory induction of cyclooxygenase-1 and Ca2+-dependent phospholipase A2. J Neurochem. 2004;91:1389-97 pubmed
    ..Overall, the data suggest that compensatory mechanisms exist in COX-2(-/-) mice and that mPGES-2 is functionally coupled with COX-2. ..
  8. Zhang M, Yao B, Wang Y, Yang S, Wang S, Fan X, et al. Inhibition of cyclooxygenase-2 in hematopoietic cells results in salt-sensitive hypertension. J Clin Invest. 2015;125:4281-94 pubmed publisher
    ..Moreover, these results indicate that inhibiting COX-2 expression or activity in hematopoietic cells can result in a predisposition to salt-sensitive hypertension. ..