Ptges

Summary

Gene Symbol: Ptges
Description: prostaglandin E synthase
Alias: 2410099E23Rik, D2Ertd369e, Pges, mPGES, mPGES-1, prostaglandin E synthase, microsomal prostaglandin E synthase 1
Species: mouse

Top Publications

  1. doi Endothelial microsomal prostaglandin E synthase-1 facilitates neurotoxicity by elevating astrocytic Ca2+ levels
    Takako Takemiya
    Medical Research Institute, Tokyo Women s Medical University, Shinjuku, Tokyo, Japan
    Neurochem Int 58:489-96. 2011
  2. pmc Microsomal prostaglandin E synthase-1 in both cancer cells and hosts contributes to tumour growth, invasion and metastasis
    Daisuke Kamei
    The Department of Health Chemistry, School of Pharmacy, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Biochem J 425:361-71. 2009
  3. pmc mPGES-1 null mice are resistant to bleomycin-induced skin fibrosis
    Matthew R McCann
    Osteoarthritis Research Unit, University of Montreal Hospital Research Center CR CHUM and Department of Medicine, University of Montreal, 1560 rue Sherbrooke Est, Montreal, Quebec, H2L 4M1, Canada
    Arthritis Res Ther 13:R6. 2011
  4. pmc Lack of microsomal prostaglandin E synthase-1 reduces cardiac function following angiotensin II infusion
    Pamela Harding
    Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, Detroit, Michigan 48202, USA
    Am J Physiol Heart Circ Physiol 300:H1053-61. 2011
  5. doi Microsomal prostaglandin E synthase-1 deletion suppresses oxidative stress and angiotensin II-induced abdominal aortic aneurysm formation
    Miao Wang
    Institute for Translational Medicine and Therapeutics, 153 Johnson Pavilion, University of Pennsylvania, 3620 Hamilton Walk, Philadelphia, PA 19104, USA
    Circulation 117:1302-9. 2008
  6. doi Tobacco smoke regulates the expression and activity of microsomal prostaglandin E synthase-1: role of prostacyclin and NADPH-oxidase
    Silvia S Barbieri
    Centro Cardiologico Monzino, IRCCS, Via Parea 4, 20138 Milano, Italy
    FASEB J 25:3731-40. 2011
  7. doi Roles of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 expression and beta-catenin activation in gastric carcinogenesis in N-methyl-N-nitrosourea-treated K19-C2mE transgenic mice
    Shinji Takasu
    Division of Oncological Pathology, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Cancer Sci 99:2356-64. 2008
  8. ncbi Expression of microsomal prostaglandin E synthase-1 in the spinal cord in a transgenic mouse model of amyotrophic lateral sclerosis
    Hiroko Miyagishi
    Laboratory of Pharmacology, School of Pharmacy, Nihon University, Japan
    J Pharmacol Sci 118:225-36. 2012
  9. ncbi Microglia-specific expression of microsomal prostaglandin E2 synthase-1 contributes to lipopolysaccharide-induced prostaglandin E2 production
    Yuri Ikeda-Matsuo
    Laboratory of Pharmacology, School of Pharmaceutical Sciences, Kitasato University, 5 9 1 Shirokane, Minato ku, Tokyo, Japan
    J Neurochem 94:1546-58. 2005
  10. ncbi Immunohistochemical localization of microsomal PGE synthase-1 and cyclooxygenases in male mouse reproductive organs
    Michael Lazarus
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Suita, Osaka 565 0874, Japan
    Endocrinology 143:2410-9. 2002

Research Grants

Scientific Experts

  • Youfei Guan
  • Yuri Ikeda-Matsuo
  • Takako Takemiya
  • Dongmei Wu
  • LOUISE HOWE
  • Erwan Le Maitre
  • Helena Idborg
  • P Harding
  • Masanobu Oshima
  • Silvia S Barbieri
  • Miao Wang
  • Mohit Kapoor
  • Satoshi Uematsu
  • Zhanjun Jia
  • Shizuo Akira
  • Tianxin Yang
  • Per Johan Jakobsson
  • Daisuke Kamei
  • Norbert Degousee
  • Makoto Murakami
  • Maziar Divangahi
  • Masataka Majima
  • Etsushi Kuroda
  • Ichiro Kudo
  • Sipra Saha
  • Laurent P Audoly
  • Shuntaro Hara
  • Tatsunori Suzuki
  • Kanako Hosono
  • Beverly H Koller
  • Zheng Dong
  • Marjolaine Gosset
  • Yukio Ishikawa
  • Toshiharu Ishii
  • Leslie J Crofford
  • Veronica Siljehav
  • Carlo Angioni
  • Aihua Zhang
  • Gerd Geisslinger
  • Hiroko Oshima
  • Fumiaki Kojima
  • Shafie Fazel
  • Barry B Rubin
  • Thomas F Lindsay
  • Denis Angoulvant
  • Catherine E Trebino
  • Eva Stefanski
  • Ren Ke Li
  • Leigh A Jania
  • Yoshihito Nakatani
  • E Pecchi
  • Jennifer M Dolan
  • Meghedi N Aghourian
  • M Dallaporta
  • Kiyofumi Yamakawa
  • Hua Ni
  • Francois Coulombe
  • Michael Lazarus
  • Martina Kovarova
  • Linda Engström
  • Anders Blomqvist
  • Ying Sun
  • Kazunari Sugita
  • Yoshihiro Urade
  • Gang Liu
  • David Engblom
  • Hiroko Miyagishi
  • Tomoya Shiro
  • Rachel J Church
  • Wataru Yoshioka
  • S Donnini
  • Y Sasaki
  • Yukiko Kuroki
  • K M Faisal Khan
  • Susan Parazzoli
  • Helmut Schmidt
  • Klaus Scholich
  • Akiko Numao
  • Matthew R McCann
  • M Murakami
  • Hiroyasu Sato
  • S U Monrad
  • Christian Brenneis
  • Izumi Hayashi
  • Masako Isono
  • Toshinori Aoyagi
  • Yuka Sasaki
  • Kenji Kabashima
  • Hiroki Kamata
  • Haiping Wang

Detail Information

Publications100

  1. doi Endothelial microsomal prostaglandin E synthase-1 facilitates neurotoxicity by elevating astrocytic Ca2+ levels
    Takako Takemiya
    Medical Research Institute, Tokyo Women s Medical University, Shinjuku, Tokyo, Japan
    Neurochem Int 58:489-96. 2011
    ..Recently, we found kainic acid (KA) administration induced microsomal prostaglandin E synthase-1 (mPGES-1) and prostaglandin E(2) (PGE(2)) receptor EP3 in venous endothelia and on astrocytes, ..
  2. pmc Microsomal prostaglandin E synthase-1 in both cancer cells and hosts contributes to tumour growth, invasion and metastasis
    Daisuke Kamei
    The Department of Health Chemistry, School of Pharmacy, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Biochem J 425:361-71. 2009
    mPGES-1 (microsomal prostaglandin E synthase-1) is a stimulus-inducible enzyme that functions downstream of COX (cyclo-oxygenase)-2 in the PGE2 (prostaglandin E2)-biosynthesis pathway...
  3. pmc mPGES-1 null mice are resistant to bleomycin-induced skin fibrosis
    Matthew R McCann
    Osteoarthritis Research Unit, University of Montreal Hospital Research Center CR CHUM and Department of Medicine, University of Montreal, 1560 rue Sherbrooke Est, Montreal, Quebec, H2L 4M1, Canada
    Arthritis Res Ther 13:R6. 2011
    Microsomal prostaglandin E2 synthase-1 (mPGES-1) is an inducible enzyme that acts downstream of cyclooxygenase (COX) to specifically catalyze the conversion of prostaglandin (PG) H2 to PGE2...
  4. pmc Lack of microsomal prostaglandin E synthase-1 reduces cardiac function following angiotensin II infusion
    Pamela Harding
    Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, Detroit, Michigan 48202, USA
    Am J Physiol Heart Circ Physiol 300:H1053-61. 2011
    Our laboratory previously reported that inducible PGE(2) synthase, mPGES-1, contributes to micromolar production of PGE(2) in neonatal ventricular myocytes in vitro, which stimulates their growth...
  5. doi Microsomal prostaglandin E synthase-1 deletion suppresses oxidative stress and angiotensin II-induced abdominal aortic aneurysm formation
    Miao Wang
    Institute for Translational Medicine and Therapeutics, 153 Johnson Pavilion, University of Pennsylvania, 3620 Hamilton Walk, Philadelphia, PA 19104, USA
    Circulation 117:1302-9. 2008
    Microsomal prostaglandin (PG) E(2) synthase-1 (mPGES-1) catalyzes isomerization of the cyclooxygenase product PGH(2) into PGE(2). Deletion of mPGES-1 modulates experimentally evoked pain and inflammation and retards atherogenesis...
  6. doi Tobacco smoke regulates the expression and activity of microsomal prostaglandin E synthase-1: role of prostacyclin and NADPH-oxidase
    Silvia S Barbieri
    Centro Cardiologico Monzino, IRCCS, Via Parea 4, 20138 Milano, Italy
    FASEB J 25:3731-40. 2011
    ..We explored molecular mechanisms by which TS/IL-1β alters expression and activity of microsomal-prostaglandin E synthase-1 (mPGES-1) and of prostacyclin synthase (PGIS) in mouse cardiac endothelial cells...
  7. doi Roles of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 expression and beta-catenin activation in gastric carcinogenesis in N-methyl-N-nitrosourea-treated K19-C2mE transgenic mice
    Shinji Takasu
    Division of Oncological Pathology, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Cancer Sci 99:2356-64. 2008
    K19-C2mE transgenic (Tg) mice, simultaneously expressing cyclooxygenase-2 (COX-2) and microsomal prostaglandin E synthase-1 (mPGES-1) in the gastric mucosa under the cytokeratin 19 gene promoter, were here treated with N-methyl-N-..
  8. ncbi Expression of microsomal prostaglandin E synthase-1 in the spinal cord in a transgenic mouse model of amyotrophic lateral sclerosis
    Hiroko Miyagishi
    Laboratory of Pharmacology, School of Pharmacy, Nihon University, Japan
    J Pharmacol Sci 118:225-36. 2012
    ..Experiments were performed to elucidate the expression of PGESs and the localization of microsomal PGES-1 (mPGES-1) in neurons and glial cells in the spinal cord of ALS model (G93A) mice...
  9. ncbi Microglia-specific expression of microsomal prostaglandin E2 synthase-1 contributes to lipopolysaccharide-induced prostaglandin E2 production
    Yuri Ikeda-Matsuo
    Laboratory of Pharmacology, School of Pharmaceutical Sciences, Kitasato University, 5 9 1 Shirokane, Minato ku, Tokyo, Japan
    J Neurochem 94:1546-58. 2005
    Microsomal prostaglandin E2 synthase (mPGES)-1 is an inducible protein recently shown to be an important enzyme in inflammatory prostaglandin E2 (PGE2) production in some peripheral inflammatory lesions...
  10. ncbi Immunohistochemical localization of microsomal PGE synthase-1 and cyclooxygenases in male mouse reproductive organs
    Michael Lazarus
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Suita, Osaka 565 0874, Japan
    Endocrinology 143:2410-9. 2002
    We investigated the tissue distribution and cellular localization of microsomal PGE synthase-1 (mPGES-1) and cyclooxygenase (COX)-1 and -2 in the male mouse reproductive organs...
  11. doi mPGES-1 knock-out mice are resistant to cancer-induced anorexia despite the absence of central mPGES-1 up-regulation in wild-type anorexic mice
    E Pecchi
    Centre de Recherche en Neurobiologie Neurophysiologie de Marseille CRN2M, UMR 6231 CNRS, Université Paul Cézanne and Université de la Méditerranée, Marseille, France
    J Neuroimmunol 199:104-14. 2008
    ..The present study was designed to address the possible involvement of the inducible microsomal prostaglandin E synthase-1 (mPGES-1) in the hypopaghia observed during these pathological states...
  12. pmc Microsomal prostaglandin E synthase-1 and cyclooxygenase-2 are both required for ischaemic excitotoxicity
    Y Ikeda-Matsuo
    Kitasato University, Tokyo, Japan
    Br J Pharmacol 159:1174-86. 2010
    Although both microsomal prostaglandin E synthase (mPGES)-1 and cyclooxygenase (COX)-2 are critical factors in stroke injury, but the interactions between these enzymes in the ischaemic brain is still obscure...
  13. pmc Microsomal prostaglandin E synthase-1 is a critical factor of stroke-reperfusion injury
    Yuri Ikeda-Matsuo
    Laboratory of Pharmacology, School of Pharmaceutical Sciences, Kitasato University, Tokyo 108 8641, Japan
    Proc Natl Acad Sci U S A 103:11790-5. 2006
    ..Here we demonstrate the induction of microsomal PGE synthase 1 (mPGES-1), an inducible terminal enzyme for PGE(2) synthesis, in neurons, microglia, and endothelial cells in the ..
  14. pmc Prostaglandin E2 synthesis in cartilage explants under compression: mPGES-1 is a mechanosensitive gene
    Marjolaine Gosset
    UMR 7079 CNRS, Physiology and Physiopathology Laboratory, University Paris 6, quai St Bernard, Paris, 75252 Cedex 5, France
    Arthritis Res Ther 8:R135. 2006
    ..Its synthesis is the result of cyclooxygenase (COX) and prostaglandin E synthase (PGES) activities whereas NAD+-dependent 15 hydroxy prostaglandin dehydrogenase (15-PGDH) is the key ..
  15. doi Comparison of microsomal prostaglandin E synthase-1 deletion and COX-2 inhibition in acute cardiac ischemia in mice
    Dongmei Wu
    Department of Research, Division of Neonatology, Mount Sinai Medical Center, 4300 Alton Road, Miami Beach, FL 33140, USA
    Prostaglandins Other Lipid Mediat 90:21-5. 2009
    The aim of the present study was to compare the effects of genetic mPGES-1 loss and COX-2 inhibition on myocardial damage after coronary occlusion...
  16. ncbi Biochemical characterization of mouse microsomal prostaglandin E synthase-1 and its colocalization with cyclooxygenase-2 in peritoneal macrophages
    Michael Lazarus
    Department of Molecular Behavioral Biology, Japan Science and Technology Corporation, Osaka Bioscience Institute, Suita, Osaka 565 0874, Japan
    Arch Biochem Biophys 397:336-41. 2002
    We cloned the cDNA for mouse microsomal prostaglandin (PG) E synthase-1 (mPGES-1) and expressed the recombinant enzyme in Escherichia coli...
  17. ncbi Microsomal prostaglandin E synthase-1 is the central switch during immune-induced pyresis
    David Engblom
    Division of Cell Biology, Faculty of Health Sciences, University of Linkoping, S 581 85 Linkoping, Sweden
    Nat Neurosci 6:1137-8. 2003
    We studied the febrile response in mice deficient in microsomal prostaglandin E synthase-1 (mPGES-1), an inducible terminal isomerase expressed in cytokine-sensitive brain endothelial cells...
  18. doi Amelioration of cisplatin nephrotoxicity by genetic or pharmacologic blockade of prostaglandin synthesis
    Zhanjun Jia
    Department of Internal Medicine, University of Utah, Salt Lake City, Utah 84132, USA
    Kidney Int 79:77-88. 2011
    ..injury, inflammation, oxidative stress, and arachidonate metabolism were all diminished in microsomal prostaglandin E synthase-1 (mPGES-1) null mice; a phenotype recapitulated by treatment of wild-type mice with the COX-2 inhibitor ..
  19. pmc Defective generation of a humoral immune response is associated with a reduced incidence and severity of collagen-induced arthritis in microsomal prostaglandin E synthase-1 null mice
    Fumiaki Kojima
    Division of Rheumatology, Department of Internal Medicine, University of Kentucky, Lexington, KY 40536, USA
    J Immunol 180:8361-8. 2008
    Microsomal PGE synthase-1 (mPGES-1) is an inducible enzyme that acts downstream of cyclooxygenase and specifically catalyzes the conversion of PGH(2) to PGE(2)...
  20. ncbi Regulation of prostaglandin E2 biosynthesis by inducible membrane-associated prostaglandin E2 synthase that acts in concert with cyclooxygenase-2
    M Murakami
    Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    J Biol Chem 275:32783-92. 2000
    ..the molecular identification of membrane-bound glutathione (GSH)-dependent prostaglandin (PG) E(2) synthase (mPGES), a terminal enzyme of the cyclooxygenase (COX)-2-mediated PGE(2) biosynthetic pathway...
  21. pmc Mice lacking mPGES-1 are resistant to lithium-induced polyuria
    Zhanjun Jia
    Univ of Utah and VA Medical Center, Salt Lake City, UT 84132, USA
    Am J Physiol Renal Physiol 297:F1689-96. 2009
    ..The present study was undertaken to assess lithium-induced polyuria in mice deficient in microsomal prostaglandin E synthase-1 (mPGES-1). A 2-wk administration of LiCl (4 mmol.kg(-1)...
  22. ncbi Cellular prostaglandin E2 production by membrane-bound prostaglandin E synthase-2 via both cyclooxygenases-1 and -2
    Makoto Murakami
    Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    J Biol Chem 278:37937-47. 2003
    ..evidence suggests that two forms of prostaglandin (PG) E synthase (PGES), cytosolic PGES and membrane-bound PGES (mPGES) -1, preferentially lie downstream of cyclooxygenase (COX) -1 and -2, respectively, in the PGE2 biosynthetic ..
  23. pmc mPGES-1 deletion impairs aldosterone escape and enhances sodium appetite
    Zhanjun Jia
    Department of Internal Medicine, University of Utah and Veterans Affairs Medical Center, Salt Lake City, Utah 84132, USA
    Am J Physiol Renal Physiol 299:F155-66. 2010
    ..Here, we investigated the role of microsomal prostaglandin E synthase-1 (mPGES-1) in the response to excess Aldo. A 14-day Aldo infusion at 0...
  24. pmc Cyclooxygenase-2, not microsomal prostaglandin E synthase-1, is the mechanism for interleukin-1β-induced prostaglandin E2 production and inhibition of insulin secretion in pancreatic islets
    Susan Parazzoli
    Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle, Washington 98122, USA
    J Biol Chem 287:32246-53. 2012
    ..by two isoenzyme groups, cyclooxygenases (COX-1 and COX-2) and terminal prostaglandin E synthases (cPGES, mPGES-1, and mPGES-2). mPGES-1 is widely considered to be the final enzyme regulating COX-2-dependent PGE(2) synthesis...
  25. pmc Deletion of microsomal prostaglandin E synthase-1 augments prostacyclin and retards atherogenesis
    Miao Wang
    Institute for Translational Medicine and Therapeutics, School of Medicine, University of Pennsylvania, 3620 Hamilton Walk, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 103:14507-12. 2006
    Prostaglandin (PG) E(2) is formed from PGH(2) by a series of PGE synthase (PGES) enzymes. Microsomal PGES-1(-/-) (mPGES-1(-/-)) mice were crossed into low-density lipoprotein receptor knockout (LDLR(-/-)) mice to generate mPGES-1(-/-) ..
  26. pmc Genetic deletion of mPGES-1 abolishes PGE2 production in murine dendritic cells and alters the cytokine profile, but does not affect maturation or migration
    S U Monrad
    Department of Internal Medicine, University of Michigan, Ann Arbor, 48109, USA
    Prostaglandins Leukot Essent Fatty Acids 84:113-21. 2011
    We undertook this study to determine the role of Microsomal PGE Synthase-1 (mPGES-1), and mPGES-1-generated Prostaglandin (PG) E2 on Dendritic Cell (DC) phenotype and function...
  27. pmc Hyperplastic gastric tumors induced by activated macrophages in COX-2/mPGES-1 transgenic mice
    Hiroko Oshima
    Department of Pharmacology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    EMBO J 23:1669-78. 2004
    ..in gastric tumorigenesis, we constructed transgenic mice simultaneously expressing COX-2 and microsomal prostaglandin E synthase (mPGES)-1 in the gastric epithelial cells...
  28. ncbi Impaired febrile responses to immune challenge in mice deficient in microsomal prostaglandin E synthase-1
    Sipra Saha
    Centre for Structural Biochemistry, Karolinska Institutet, Huddinge, Sweden
    Am J Physiol Regul Integr Comp Physiol 288:R1100-7. 2005
    ..modified mice, we examined the role of the inducible terminal PGE2-synthesizing enzyme microsomal prostaglandin E synthase-1 (mPGES-1) for the generation of immune-elicited fever...
  29. ncbi Deletion of microsomal prostaglandin E2 (PGE2) synthase-1 reduces inducible and basal PGE2 production and alters the gastric prostanoid profile
    Louise Boulet
    Merck Frosst Centre for Therapeutic Research, Kirkland, Quebec H9H 3L1, Canada
    J Biol Chem 279:23229-37. 2004
    Microsomal prostaglandin E synthase-1 (mPGES-1) is an inducible protein recently shown to be an important source of inflammatory PGE2...
  30. ncbi c-Jun N-terminal kinase-mediated stabilization of microsomal prostaglandin E2 synthase-1 mRNA regulates delayed microsomal prostaglandin E2 synthase-1 expression and prostaglandin E2 biosynthesis by cardiomyocytes
    Norbert Degousee
    Divisions of Vascular Surgery and Cardiac Surgery, Toronto General Hospital Research Institute of the University Health Network, University of Toronto, Toronto, Ontario M5G 2C4, Canada
    J Biol Chem 281:16443-52. 2006
    Microsomal prostaglandin (PG) E(2) synthase-1 (mPGES-1) catalyzes the terminal step in the biosynthesis of PGE(2), a key proinflammatory mediator...
  31. pmc mPGES-1 deletion impairs diuretic response to acute water loading
    Sunhapas Soodvilai
    Department of Internal Medicine, University of Utah and Veterans Affairs Medical Center, Salt Lake City, Utah, USA
    Am J Physiol Renal Physiol 296:F1129-35. 2009
    ..The present study was undertaken to examine the role of microsomal prostaglandin E synthase-1 (mPGES-1) in the diuretic response to acute and chronic water loading...
  32. pmc Shunting of prostanoid biosynthesis in microsomal prostaglandin E synthase-1 null embryo fibroblasts: regulatory effects on inducible nitric oxide synthase expression and nitrite synthesis
    Mohit Kapoor
    Department of Internal Medicine, Rheumatology Division, Kentucky Clinic, University of Kentucky, Lexington, KY 40536 0284, USA
    FASEB J 20:2387-9. 2006
    Microsomal prostaglandin (PG) E synthase (mPGES)-1 is an inducible enzyme that acts downstream of cyclooxygenase (COX) and specifically catalyzes the conversion of prostaglandin (PG)H2 to PGE2, most prominently in inflammatory conditions...
  33. pmc Cyclooxygenases, microsomal prostaglandin E synthase-1, and cardiovascular function
    Yan Cheng
    Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 116:1391-9. 2006
    ..PGE(2) biosynthesis is catalyzed by the coordinate actions of COX enzymes and microsomal PGE synthase-1 (mPGES-1)...
  34. ncbi Coupling of COX-1 to mPGES1 for prostaglandin E2 biosynthesis in the murine mammary gland
    Subhashini Chandrasekharan
    Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Lipid Res 46:2636-48. 2005
    ..We thus provide evidence for the first time of functional coupling between COX-1 and mPGES1 in the murine mammary gland in vivo...
  35. ncbi Role of microsomal prostaglandin E synthase 1 in the kidney
    Helene Francois
    Divisions of Nephrology, Duke University and Durham Veterans Affairs Medical Centers, Durham, North Carolina 27705, USA
    J Am Soc Nephrol 18:1466-75. 2007
    ..PGE(2) is generated through enzymatic metabolism of prostanoid endoperoxides by specific PGE synthases (PGES)...
  36. pmc The induced prostaglandin E2 pathway is a key regulator of the respiratory response to infection and hypoxia in neonates
    Annika O Hofstetter
    Department of Woman and Child Health, Karolinska Institutet, 171 76 Stockholm, Sweden
    Proc Natl Acad Sci U S A 104:9894-9. 2007
    ..IL-1beta and transient anoxia rapidly induced brainstem-specific microsomal prostaglandin E synthase-1 (mPGES-1) activity in neonatal mice...
  37. ncbi Lipopolysaccharide-dependent prostaglandin E(2) production is regulated by the glutathione-dependent prostaglandin E(2) synthase gene induced by the Toll-like receptor 4/MyD88/NF-IL6 pathway
    Satoshi Uematsu
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
    J Immunol 168:5811-6. 2002
    ..Membrane-bound glutathione-dependent PGE(2) synthase (mPGES) has been shown to be a terminal enzyme of the cyclooxygenase-2-mediated PGE(2) biosynthesis...
  38. doi Microsomal prostaglandin synthase-1-derived prostaglandin E2 protects against angiotensin II-induced hypertension via inhibition of oxidative stress
    Zhanjun Jia
    Department of Internal Medicine, University of Utah and Veterans Affairs Medical Center, Salt Lake City, UT 84132, USA
    Hypertension 52:952-9. 2008
    ..The present study examined the role and mechanism of microsomal PG synthase-1 (mPGES-1) in vascular response to angiotensin II (Ang II) infusion. A 7-day Ang II infusion at 0...
  39. doi Silica crystals and aluminum salts regulate the production of prostaglandin in macrophages via NALP3 inflammasome-independent mechanisms
    Etsushi Kuroda
    Department of Immunology and Parasitology, University of Occupational and Environmental Health, Japan, Kitakyushu, Fukuoka 807 8555, Japan
    Immunity 34:514-26. 2011
    ..PGE₂ expression was markedly reduced in PGE synthase-deficient (Ptges⁻/⁻) macrophages, and Ptges⁻/⁻ mice displayed reduced antigen-specific serum IgE concentrations after ..
  40. ncbi Membrane-associated PGE synthase-1 (mPGES-1) is coexpressed with both COX-1 and COX-2 in the kidney
    Andre Schneider
    Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Kidney Int 65:1205-13. 2004
    ..The present studies were aimed at determining the intrarenal localization of mPGES-1 and whether it is coexpressed with COX-1 or COX-2.
  41. doi Genetic deletion of mPGES-1 accelerates intestinal tumorigenesis in APC(Min/+) mice
    N Elander
    Department of Clinical and Experimental Medicine, Division of Cell Biology, Faculty of Health Sciences, Linkoping University, SE 58185 Linkoping, Sweden
    Biochem Biophys Res Commun 372:249-53. 2008
    ..Here we demonstrate that APC(Min/+) mice with genetic deletion of microsomal prostaglandin E synthase-1 (mPGES-1), which catalyses the terminal conversion of PGH(2) into PGE(2), surprisingly develop more and ..
  42. ncbi Reduced pain hypersensitivity and inflammation in mice lacking microsomal prostaglandin e synthase-1
    Daisuke Kamei
    Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    J Biol Chem 279:33684-95. 2004
    We examined the in vivo role of membrane-bound prostaglandin E synthase (mPGES)-1, a terminal enzyme in the PGE2-biosynthetic pathway, using mPGES-1 knockout (KO) mice...
  43. ncbi Transcriptional regulation of the membrane-associated prostaglandin E2 synthase gene. Essential role of the transcription factor Egr-1
    Hiroaki Naraba
    Department of Pharmacology, National Cardiovascular Center Research Institute, 5 7 1 Fujishiro dai, Suita, Osaka 565 8565, Japan
    J Biol Chem 277:28601-8. 2002
    Membrane-associated prostaglandin (PG) E2 synthase (mPGES) is an inducible terminal enzyme in the biosynthetic pathway for prostaglandin E2, which participates in many biological processes...
  44. ncbi Urogenital distribution of a mouse membrane-associated prostaglandin E(2) synthase
    Y Guan
    Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37212, USA
    Am J Physiol Renal Physiol 281:F1173-7. 2001
    ..In the present studies, we report the functional expression of a membrane-associated murine PGES (mPGES) and its expression in urogenital tissues...
  45. pmc Targeted lipidomics reveals mPGES-1-PGE2 as a therapeutic target for multiple sclerosis
    Yasuyuki Kihara
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Proc Natl Acad Sci U S A 106:21807-12. 2009
    ..Here, using an AA cascade-targeted lipidomics approach, we report that microsomal PGE synthase 1 (mPGES-1) plays a key role in experimental autoimmune encephalomyelitis (EAE)...
  46. doi Genetic deletion of mPGES-1 suppresses intestinal tumorigenesis
    Masako Nakanishi
    Center for Molecular Medicine, Department of Cell Biology, University of Connecticut Health Center, Farmington, CT 06030 3101, USA
    Cancer Res 68:3251-9. 2008
    ..study, we evaluated the chemopreventive efficacy of targeting the terminal synthase microsomal PGE(2) synthase 1 (mPGES-1), which is responsible for generating PGE(2), in two murine models of intestinal cancer...
  47. doi Microsomal prostaglandin E2 synthase-1 deletion leads to adverse left ventricular remodeling after myocardial infarction
    Norbert Degousee
    Division of Vascular Surgery, University of Toronto, Toronto, Ontario, Canada M5G 2C4
    Circulation 117:1701-10. 2008
    ..Microsomal prostaglandin (PG) E(2) synthase-1 (mPGES-1), encoded by the Ptges gene, functions downstream from cyclooxygenase-2 in the inducible PGE(2) biosynthetic ..
  48. pmc Impaired inflammatory and pain responses in mice lacking an inducible prostaglandin E synthase
    Catherine E Trebino
    Inflammation, Pfizer Global Research and Development, Groton Laboratories, Groton, CT 06340, USA
    Proc Natl Acad Sci U S A 100:9044-9. 2003
    ..These findings suggest that mPGES1 provides a target for the treatment of inflammatory diseases and pain associated with inflammatory states...
  49. ncbi Deletion of microsomal prostaglandin E synthase-1 increases sensitivity to salt loading and angiotensin II infusion
    Zhanjun Jia
    Department of Internal Medicine, University of Utah and Veterans Affairs Medical Center, Salt Lake City, UT 84132, USA
    Circ Res 99:1243-51. 2006
    Microsomal prostaglandin E synthase-1 (mPGES-1), a membrane-associated protein, is critically involved in the inflammatory response and may be involved in physiological processes as well...
  50. ncbi Redirection of eicosanoid metabolism in mPGES-1-deficient macrophages
    Catherine E Trebino
    Inflammation, Pfizer Global Research and Development, Groton Laboratories, Pfizer Inc, Groton, Connecticut 06340, USA
    J Biol Chem 280:16579-85. 2005
    Microsomal prostaglandin E synthase (mPGES)-1 is one of several prostaglandin E synthases involved in prostaglandin H2 (PGH2) metabolism...
  51. pmc Increased lethality and defective pulmonary clearance of Streptococcus pneumoniae in microsomal prostaglandin E synthase-1-knockout mice
    Jennifer M Dolan
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan
    Am J Physiol Lung Cell Mol Physiol 310:L1111-20. 2016
    ..Microsomal prostaglandin E synthase-1 (mPGES-1) is a key enzyme involved in the synthesis of PGE2, and its expression is enhanced during ..
  52. doi Microsomal prostaglandin E synthase-1 enhances bone cancer growth and bone cancer-related pain behaviors in mice
    Masako Isono
    Department of Pharmacology, Kitasato University School of Medicine, Sagamihara, Kanagawa 228 8555, Japan
    Life Sci 88:693-700. 2011
    ..Microsomal PGE synthase-1 (mPGES-1) is an inducible enzyme that catalyzes isomerization of the endoperoxide PGH(2) to PGE(2)...
  53. pmc Anti-inflammatory role of microsomal prostaglandin E synthase-1 in a model of neuroinflammation
    Christian Brenneis
    Institute of Clinical Pharmacology, Pharmazentrum Frankfurt, ZAFES, Hospital of the Goethe University, 60590 Frankfurt, Germany
    J Biol Chem 286:2331-42. 2011
    ..Here, we investigated the role of microsomal PGE(2) synthase-1 (mPGES-1), which is functionally coupled to COX-2, in immune responses using a model of lipopolysaccharide (LPS)-induced ..
  54. doi Prostaglandin E2 produced by microsomal prostaglandin E synthase-1 regulates the onset and the maintenance of wakefulness
    Takako Takemiya
    Medical Research Institute, Tokyo Women s Medical University, Shinjuku, Tokyo 162 8666, Japan
    Neurochem Int 59:922-4. 2011
    This study examined the effect of prostaglandin E(2) (PGE(2)) produced by microsomal prostaglandin E synthase-1 (mPGES-1) on circadian rhythm...
  55. doi Microsomal prostaglandin E synthase-1 is involved in multiple steps of colon carcinogenesis
    Y Sasaki
    Department of Health Chemistry, School of Pharmacy, Showa University, Tokyo, Japan
    Oncogene 31:2943-52. 2012
    ..However, the precise contribution of microsomal PGE synthase (mPGES)-1, a terminal enzyme that acts downstream of COX-2 in the PGE(2)-biosynthetic pathway, to multiple processes of ..
  56. doi EGFR signaling upregulates expression of microsomal prostaglandin E synthase-1 in cancer cells leading to enhanced tumorigenicity
    S Donnini
    Section of Pharmacology, Department of Biotechnology, University of Siena, and Istituto Toscano Tumori, Siena, Italy
    Oncogene 31:3457-66. 2012
    ..the contribution of prostaglandin E(2) (PGE(2)) derived from the inducible microsomal PGE-synthase type-1 (mPGES-1) to the epidermal growth factor receptor (EGFR) oncogenic drive in tumor epithelial cells and in tumor-bearing ..
  57. doi Synthesis and SAR study of imidazoquinolines as a novel structural class of microsomal prostaglandin E₂ synthase-1 inhibitors
    Tomoya Shiro
    Drug Research Division, Dainippon Sumitomo Pharma Co Ltd, 3 1 98 Kasugade naka, Konohana ku, Osaka 554 0022, Japan
    Bioorg Med Chem Lett 22:285-8. 2012
    The imidazoquinoline derivative 1 was found as a novel mPGES-1 inhibitor. Optimization of 1 led to the identification of the 2-chlorophenyl group at the C(2)-position and the quinolone structure at the C(4)-position...
  58. pmc Matrix metalloproteinase-dependent microsomal prostaglandin E synthase-1 expression in macrophages: role of TNF-α and the EP4 prostanoid receptor
    K M Faisal Khan
    Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10065, USA
    J Immunol 188:1970-80. 2012
    ..study, we determined whether MMP-induced cyclooxygenase-2 expression was coupled to the expression of prostaglandin E synthase family members...
  59. pmc mPGES-1 deletion potentiates urine concentrating capability after water deprivation
    Zhanjun Jia
    Department of Internal Medicine, Veterans Affairs Medical Center, University of Utah, Salt Lake City, UT 84132, USA
    Am J Physiol Renal Physiol 302:F1005-12. 2012
    ..The present study was undertaken to investigate the potential role of microsomal PGE synthase (mPGES)-1 in the regulation of urine concentrating ability after water deprivation (WD)...
  60. pmc Prostaglandin E(2) produced by the lung augments the effector phase of allergic inflammation
    Rachel J Church
    Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Immunol 188:4093-102. 2012
    ..Together, this supports a model in which mPGES1-dependent PGE(2) produced by populations of cells native to the lung contributes to the effector phase of some allergic responses...
  61. doi Critical role of microsomal prostaglandin E synthase-1 in the hydronephrosis caused by lactational exposure to dioxin in mice
    Wataru Yoshioka
    Laboratory of Environmental Health Sciences, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo 113 0033, Japan
    Toxicol Sci 127:547-54. 2012
    ..In this study, we investigated the role of microsomal prostaglandin E synthase-1 (mPGES-1), an inducible form of PGE(2) synthase, in TCDD-induced hydronephrosis...
  62. doi Lack of microsomal prostaglandin E(2) synthase-1 in bone marrow-derived myeloid cells impairs left ventricular function and increases mortality after acute myocardial infarction
    Norbert Degousee
    Division of Vascular Surgery, Toronto General Hospital, University Health Network, Toronto, Canada
    Circulation 125:2904-13. 2012
    Microsomal prostaglandin E(2) synthase-1 (mPGES-1), encoded by the Ptges gene, catalyzes prostaglandin E(2) biosynthesis and is expressed by leukocytes, cardiac myocytes, and cardiac fibroblasts...
  63. doi Deletion of microsomal prostaglandin E synthase-1 protects neuronal cells from cytotoxic effects of β-amyloid peptide fragment 31-35
    Yukiko Kuroki
    Department of Health Chemistry, School of Pharmacy, Showa University, Tokyo 142 8555, Japan
    Biochem Biophys Res Commun 424:409-13. 2012
    ..To examine the involvement in AD pathology of microsomal PGES-1 (mPGES-1), a PGES enzyme, we here prepared primary cerebral neuronal cells from the cerebri of wild-type and mPGES-1-..
  64. pmc mPGES-1-derived PGE2 mediates dehydration natriuresis
    Zhanjun Jia
    Univ of Utah and Veterans Affairs Medical Center, Div of Nephrology and Hypertension, Salt Lake City, UT 84132, USA
    Am J Physiol Renal Physiol 304:F214-21. 2013
    ..The goal of the present study was to investigate the role of microsomal prostaglandin E synthase-1 (mPGES-1) in dehydration natriuresis...
  65. pmc Prostaglandin E₂ is critical for the development of niacin-deficiency-induced photosensitivity via ROS production
    Kazunari Sugita
    1 Department of Dermatology, University of Occupational and Environmental Health, Kitakyushu, Japan 2 Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Sci Rep 3:2973. 2013
    ..In addition, niacin deficient mice exhibited elevated expressions of COX-2 and PGE syntheses (Ptges) mRNA...
  66. doi Targeted prostaglandin E2 inhibition enhances antiviral immunity through induction of type I interferon and apoptosis in macrophages
    Francois Coulombe
    Department of Medicine, Department of Microbiology and Immunology, Department of Pathology, McGill International TB Centre, McGill University Health Centre and Research Institute, Meakins Christie Laboratories, 3626 St Urbain Street, Montreal, Quebec H2X 2P2, Canada
    Immunity 40:554-68. 2014
    ..Targeted PGE2 suppression via genetic ablation of microsomal prostaglandin E-synthase 1 (mPGES-1) or by the pharmacological inhibition of PGE2 receptors EP2 and EP4 substantially improved survival against ..
  67. pmc COX-2 but not mPGES-1 contributes to renal PGE2 induction and diabetic proteinuria in mice with type-1 diabetes
    Zhanjun Jia
    Department of Internal Medicine, University of Utah and Veterans Affairs Medical Center, Salt Lake City, Utah, United States of America
    PLoS ONE 9:e93182. 2014
    ..To elucidate whether mPGES-1, the best characterized PGE2 synthase, was involved in the development of DN, we examined the renal phenotype of ..
  68. pmc PGE₂ promotes apoptosis induced by cytokine deprivation through EP3 receptor and induces Bim in mouse mast cells
    Martina Kovarova
    Department of Medicine, Pulmonary Division, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, United States of America
    PLoS ONE 9:e102948. 2014
    ..This supports a model in which PGE2 can contribute to the resolution of inflammation in part by augmenting the removal of inflammatory cells in this case, mast cells. ..
  69. doi Prostaglandin E synthase is upregulated by Gas6 during cancer-induced venous thrombosis
    Meghedi N Aghourian
    Lady Davis Institute and
    Blood 127:769-77. 2016
    ..WT and Gas6(-/-) endothelial cells exposed to M27 murine lung carcinoma cells reveal that Gas6 increases prostaglandin E synthase (Ptges) expression in endothelial cells...
  70. doi Inhibition of matrix metalloproteinase-3 and -13 synthesis induced by IL-1beta in chondrocytes from mice lacking microsomal prostaglandin E synthase-1
    Marjolaine Gosset
    Pierre and Marie Curie University, Paris, France
    J Immunol 185:6244-52. 2010
    ..the role of PGE(2) on MMP synthesis in articular chondrocytes using mice lacking microsomal PGE synthase-1 (mPGES-1), which catalyses the rate-limiting step of PGE(2) synthesis...
  71. ncbi Membrane-associated prostaglandin E synthase-1 is required for neuropathic pain
    Tamaki Mabuchi
    Department of Medical Chemistry, Kansai Medical University, 10 15 Fumizono, Moriguchi 570 8506, Japan
    Neuroreport 15:1395-8. 2004
    ..acid via PGH2 by at least three PGE synthases (PGES), cytosolic PGES (cPGES), and membrane-associated PGES (mPGES)-1 and -2...
  72. ncbi Membrane-bound prostaglandin E synthase-1-mediated prostaglandin E2 production by osteoblast plays a critical role in lipopolysaccharide-induced bone loss associated with inflammation
    Masaki Inada
    Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, Tokyo, Japan
    J Immunol 177:1879-85. 2006
    ..In this study, we examined the role of PGE(2) in LPS-induced bone resorption using membrane-bound PGES (mPGES)-1-deficient mice (mPges1(-/-))...
  73. ncbi c-Fos immunoreactivity induced by intraperitoneal LPS administration is reduced in the brain of mice lacking the microsomal prostaglandin E synthase-1 (mPGES-1)
    M Dallaporta
    Laboratoire de Physiologie Neurovégétative, UMR 6153 CNRS 1147 INRA, Universite Paul Cezanne, Marseille, France
    Brain Behav Immun 21:1109-21. 2007
    The aim of the present study was to investigate the impact of the deletion of the microsomal prostaglandin E synthase-1 (mPGES-1) gene on lipopolysaccharide (LPS)-induced neuronal activation in central nervous structures...
  74. pmc mPGES-1 and prostaglandin E2: vital role in inflammation, hypoxic response, and survival
    Veronica Siljehav
    Neonatal Research Unit Q2 07, Department of Women s and Children s Health, Astrid Lindgren Children s Hospital, Stockholm, Sweden
    Pediatr Res 72:460-7. 2012
    ..Prostaglandin E(2) (PGE(2)) serves as a critical mediator between infection and apnea. We hypothesize that alteration of the microsomal PGE synthase-1 (mPGES-1) PGE(2) pathway influences respiratory control and response to hypoxia.
  75. ncbi Differential expression of microsomal prostaglandin e synthase at implantation sites and in decidual cells of mouse uterus
    Hua Ni
    College of Life Science, Northeast Agricultural University, Harbin 150030, China
    Biol Reprod 67:351-8. 2002
    ..There are two isoforms of PGES, microsomal PGES (mPGES) and cytosolic PGES (cPGES)...
  76. pmc Mdm2 is required for survival of hematopoietic stem cells/progenitors via dampening of ROS-induced p53 activity
    Hussein A Abbas
    Program in Genes and Development of The Graduate School of Biomedical Sciences, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Cell Stem Cell 7:606-17. 2010
    ..p16 was also stabilized because of ROS, and its loss increased cell cycling and partially rescued hematopoiesis and survival. Thus, Mdm2 is required to control ROS-induced p53 levels for sustainable hematopoiesis...
  77. ncbi Expression and regulation of cytosolic prostaglandin E synthase in mouse uterus during the peri-implantation period
    Hua Ni
    College of Life Sciences, Northeast Agricultural University, Harbin 150030, China
    Biol Reprod 68:744-50. 2003
    ..PGE synthase (PGES) catalyzes the isomerization of PGH(2) to PGE(2). Two isoforms of PGES exist: microsomal PGES (mPGES) and cytosolic PGES (cPGES); however, the expression and regulation of cPGES in the mammalian uterus during early ..
  78. ncbi Destruction of pancreatic beta-cells by transgenic induction of prostaglandin E2 in the islets
    Hiroko Oshima
    Division of Genetics, Cancer Research Institute, Kanazawa University, Kanazawa 920 0934, Japan
    J Biol Chem 281:29330-6. 2006
    ..beta-cells, we generated transgenic mice (RIP-C2mE) that express cyclooxygenase-2 and microsomal prostaglandin E synthase-1 in their beta-cells using the rat insulin-2 gene promoter (RIP)...
  79. pmc Facilitation of Th1-mediated immune response by prostaglandin E receptor EP1
    Miyako Nagamachi
    Department of Pharmacology, Faculty of Medicine, Kyoto University, Kyoto 606 8501, Japan
    J Exp Med 204:2865-74. 2007
    ..These results suggest that PGE2 produced by dendritic cells in the lymph nodes acts on EP1 in naive T cells to promote Th1 differentiation...
  80. doi Association of microsomal prostaglandin E synthase 1 deficiency with impaired fracture healing, but not with bone loss or osteoarthritis, in mouse models of skeletal disorders
    Kiyofumi Yamakawa
    University of Tokyo, Tokyo, Japan
    Arthritis Rheum 58:172-83. 2008
    b>Prostaglandin E synthase (PGES) functions as the terminal enzyme in the biosynthesis of prostaglandin E(2) (PGE(2)) and is a potent regulator of bone and cartilage metabolism...
  81. doi Photo-crosslinking of proteins in intact cells reveals a dimeric structure of cyclooxygenase-2 and an inhibitor-sensitive oligomeric structure of microsomal prostaglandin E2 synthase-1
    Pierre Olivier Hétu
    Department of Biochemistry and Molecular Biology, Merck Frosst Centre for Therapeutic Research, Kirkland, Que, Canada
    Arch Biochem Biophys 477:155-62. 2008
    We have characterized the structures of cyclooxygenase-2 (COX-2) and microsomal prostaglandin E(2) synthase-1 (mPGES-1) in intact cells using bifunctional and photo-activatable crosslinking agents...
  82. doi Role of microsomal prostaglandin E synthase-1 (mPGES1)-derived PGE2 in patency of the ductus arteriosus in the mouse
    Barbara Baragatti
    Scuola Superiore Sant Anna and Institute of Clinical Physiology CNR, Pisa 56100, Italy
    Pediatr Res 64:523-7. 2008
    ..Accordingly, an mPGES1 inhibitor stands out as a prospective better tool, compared with the currently used COX inhibitors, for the management of premature infants with persistent ductus...
  83. pmc Increased dietary NaCl induces renal medullary PGE2 production and natriuresis via the EP2 receptor
    Jian Chen
    Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Am J Physiol Renal Physiol 295:F818-25. 2008
    ..Cytosolic prostaglandin E synthase and prostacyclin synthase were not induced by the high-salt diet...
  84. doi NF-kappaB induces PGE2-synthesizing enzymes in neurons
    Waleed Barakat
    Department of Pharmacology, University of Heidelberg, Heidelberg, Germany
    Naunyn Schmiedebergs Arch Pharmacol 380:153-60. 2009
    ..cytosolic phospholipase A-2 (cPLA-2), cyclooxygenase-2 (COX-2), and microsomal prostaglandin E(2) synthase-1 (mPGES-1), three genes that are involved in the synthesis of prostaglandin E(2) (PGE(2))...
  85. doi Role of microsomal prostaglandin E synthase-1 in the facilitation of angiogenesis and the healing of gastric ulcers
    Takako Ae
    Department of Pharmacology, Kitasato University School of Medicine, Kanagawa, Japan
    Am J Physiol Gastrointest Liver Physiol 299:G1139-46. 2010
    ..However, there has been no report on the functional relevance of microsomal PGES-1 (mPGES-1) to the physiological healing processes of gastric ulcers, or to angiogenesis, which is indispensable to the ..
  86. pmc Eicosanoid pathways regulate adaptive immunity to Mycobacterium tuberculosis
    Maziar Divangahi
    Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Nat Immunol 11:751-8. 2010
    ..Our results explain why T cell priming in response to M. tuberculosis is delayed and emphasize the importance of early immunity...
  87. doi The inducible prostaglandin E synthase mPGES-1 regulates growth of endometrial tissues and angiogenesis in a mouse implantation model
    Akiko Numao
    Department of Pharmacology, Kitasato University School of Medicine, Kanagawa 252 0374, Japan
    Biomed Pharmacother 65:77-84. 2011
    ..Microsomal prostaglandin E synthase-1 (mPGES-1) is an inducible enzyme downstream of COX-2 in prostaglandin E(2) biosynthesis...
  88. doi Cyclooxygenase-2/microsomal prostaglandin E synthase-1 complex in the preoptic-anterior hypothalamus of the mouse: involvement through fever to intravenous lipopolysaccharide
    L Gaetano
    Scuola Superiore Sant Anna, Pisa, Italy
    Acta Physiol (Oxf) 200:315-24. 2010
    ..v. pyrogens. To verify the role of centrally formed PGE₂, we examined the cyclooxygenase (COX)/prostaglandin E synthase (PGES) complex through fever to i.v. lipopolysaccharide (LPS).
  89. pmc Physiological roles of group X-secreted phospholipase A2 in reproduction, gastrointestinal phospholipid digestion, and neuronal function
    Hiroyasu Sato
    Lipid Metabolism Project, The Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan
    J Biol Chem 286:11632-48. 2011
    ..Thus, besides its inflammatory action proposed previously, sPLA(2)-X participates in physiologic processes including male fertility, gastrointestinal phospholipid digestion linked to adiposity, and neuronal outgrowth and sensing...
  90. pmc Microsomal prostaglandin e2 synthase-1 modulates the response to vascular injury
    Miao Wang
    Institute for Translational Medicine and Therapeutics, Department of Pharmacology, University of Pennsylvania, Philadelphia, USA
    Circulation 123:631-9. 2011
    ..Previous studies in mice suggest that targeting mPGES-1 may be less likely to cause hypertension or thrombosis than cyclooxygenase-2-selective inhibition or deletion in ..
  91. doi mPGES-1-expressing bone marrow-derived cells enhance tumor growth and angiogenesis in mice
    Hiroki Kamata
    Department of Pharmacology, Kitasato University School of Medicine, Kitasato 1 15 1, Kanagawa 252 0374, Japan
    Biomed Pharmacother 64:409-16. 2010
    Microsomal prostaglandin (PG) E synthase 1 (mPGES-1) is a major PGE synthase and has recently been reported to be expressed at high levels in several cancer types...
  92. pmc Prostaglandin E(2) exerts homeostatic regulation of pulmonary vascular remodeling in allergic airway inflammation
    Anders Lundequist
    Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 184:433-41. 2010
    ..by a natural allergen, we used mice lacking the critical terminal synthetic enzyme, microsomal PGE(2) synthase (mPGES)-1...
  93. pmc Mycobacterium tuberculosis evades macrophage defenses by inhibiting plasma membrane repair
    Maziar Divangahi
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Nat Immunol 10:899-906. 2009
    ..By inducing production of lipoxin A(4) (LXA(4)), which blocks PGE(2) biosynthesis, virulent Mtb prevented membrane repair and induced necrosis. Thus, virulent Mtb impairs macrophage plasma membrane repair to evade host defenses...
  94. doi The effects of microsomal prostaglandin E synthase-1 deletion in acute cardiac ischemia in mice
    Dongmei Wu
    Department of Research, Division of Neonatology, Mount Sinai Medical Center, 4300 Alton Road, Miami Beach, FL 33140, USA
    Prostaglandins Leukot Essent Fatty Acids 81:31-3. 2009
    The goal of the present study was to assess how genetic loss of microsomal prostaglandin E(2) synthase-1 (mPGES-1) affects acute cardiac ischemic damage after coronary occlusion in mice...
  95. ncbi Francisella tularensis-infected macrophages release prostaglandin E2 that blocks T cell proliferation and promotes a Th2-like response
    Matthew D Woolard
    Department of Microbiology and Immunology, University of North Carolina Chapel Hill, Chapel Hill, NC 27599, USA
    J Immunol 178:2065-74. 2007
    ..From these data, we conclude that F. tularensis can alter host T cell responses by causing macrophages to produce PGE(2). This study defines a previously unknown mechanism used by F. tularensis to modulate adaptive immunity...
  96. ncbi IL-3 is an important differentiation factor for the development of prostaglandin E2-producing macrophages between C57BL/6 and BALB/c mice
    Etsushi Kuroda
    Department of Immunology and Parasitology, University of Occupational and Environmental Health, School of Medicine, Kitakyushu, Japan
    Eur J Immunol 37:2185-95. 2007
    ..macrophages from BALB/c mice expressed larger amounts of mRNA of membrane-bound (microsomal) PGE synthase-1 (mPGES-1)...
  97. pmc Pulmonary and cardiorenal cyclooxygenase-1 (COX-1), -2 (COX-2), and microsomal prostaglandin E synthase-1 (mPGES-1) and -2 (mPGES-2) expression in a hypertension model
    Zaher A Radi
    Drug Safety Research and Development, Pfizer Global Research and Development, 2800 Plymouth Road, Building 50 G0503, Ann Arbor, MI 48105, USA
    Mediators Inflamm 2007:85091. 2007
    ..Our study investigated the cellular localization and distribution of COX-1, COX-2, mPGES-1, and mPGES-2 in organ tissues from a mouse model of human hypertension...
  98. ncbi Prostaglandin E2 protects lower airways against bronchoconstriction
    John M Hartney
    Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, NC 27599, USA
    Am J Physiol Lung Cell Mol Physiol 290:L105-13. 2006
    ..Hpgd-/-), the major catabolic enzyme of PGE2, and by generating a transgenic line in which mouse PGE2 synthase (Ptges) expression is driven by a human lung-specific promoter, hSP-C...
  99. ncbi Role of cytosolic phospholipase A(2) in prostaglandin E(2) production by lung fibroblasts
    Moumita Ghosh
    Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson St, Denver, CO 80206, USA
    Am J Respir Cell Mol Biol 30:91-100. 2004
    ..Unlike primary fibroblasts, immortalized cells were deficient in microsomal PGE synthase (mPGES) but expressed slightly higher levels of cytosolic PGES...
  100. doi Inducible prostaglandin E2 synthesis interacts in a temporally supplementary sequence with constitutive prostaglandin-synthesizing enzymes in creating the hypothalamic-pituitary-adrenal axis response to immune challenge
    Louise Elander
    Division of Cell Biology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linkoping University, S 581 85 Linkoping, Sweden
    J Neurosci 29:1404-13. 2009
    ..of prostaglandin E(2)-synthesizing enzymes, including cyclooxygenase-1 (Cox-1), Cox-2, and microsomal prostaglandin E synthase-1 (mPGES-1)...

Research Grants2

  1. Combination Chemoprevention of ER-Negative Breast Cancer
    LOUISE HOWE; Fiscal Year: 2004
    ..The results of this study will provide the basis for evaluating this combination approach in women at high risk for breast cancer. ..
  2. Aspirin for Breast Cancer Prevention
    LOUISE HOWE; Fiscal Year: 2006
    ..abstract_text> ..