Ptges

Summary

Gene Symbol: Ptges
Description: prostaglandin E synthase
Alias: 2410099E23Rik, D2Ertd369e, Pges, mPGES, mPGES-1, prostaglandin E synthase, microsomal prostaglandin E synthase 1
Species: mouse
Products:     Ptges

Top Publications

  1. Guan Y, Zhang Y, Schneider A, Riendeau D, Mancini J, Davis L, et al. Urogenital distribution of a mouse membrane-associated prostaglandin E(2) synthase. Am J Physiol Renal Physiol. 2001;281:F1173-7 pubmed
    ..In the present studies, we report the functional expression of a membrane-associated murine PGES (mPGES) and its expression in urogenital tissues...
  2. Jia Z, Guo X, Zhang H, Wang M, Dong Z, Yang T. Microsomal prostaglandin synthase-1-derived prostaglandin E2 protects against angiotensin II-induced hypertension via inhibition of oxidative stress. Hypertension. 2008;52:952-9 pubmed publisher
    ..The present study examined the role and mechanism of microsomal PG synthase-1 (mPGES-1) in vascular response to angiotensin II (Ang II) infusion. A 7-day Ang II infusion at 0...
  3. Elander N, Ungerbäck J, Olsson H, Uematsu S, Akira S, Soderkvist P. Genetic deletion of mPGES-1 accelerates intestinal tumorigenesis in APC(Min/+) mice. Biochem Biophys Res Commun. 2008;372:249-53 pubmed publisher
    ..Here we demonstrate that APC(Min/+) mice with genetic deletion of microsomal prostaglandin E synthase-1 (mPGES-1), which catalyses the terminal conversion of PGH(2) into PGE(2), surprisingly develop more and ..
  4. Jia Z, Aoyagi T, Kohan D, Yang T. mPGES-1 deletion impairs aldosterone escape and enhances sodium appetite. Am J Physiol Renal Physiol. 2010;299:F155-66 pubmed publisher
    ..Here, we investigated the role of microsomal prostaglandin E synthase-1 (mPGES-1) in the response to excess Aldo. A 14-day Aldo infusion at 0...
  5. Monrad S, Kojima F, Kapoor M, Kuan E, Sarkar S, Randolph G, et al. Genetic deletion of mPGES-1 abolishes PGE2 production in murine dendritic cells and alters the cytokine profile, but does not affect maturation or migration. Prostaglandins Leukot Essent Fatty Acids. 2011;84:113-21 pubmed publisher
    We undertook this study to determine the role of Microsomal PGE Synthase-1 (mPGES-1), and mPGES-1-generated Prostaglandin (PG) E2 on Dendritic Cell (DC) phenotype and function...
  6. Cheng Y, Wang M, Yu Y, Lawson J, Funk C, Fitzgerald G. Cyclooxygenases, microsomal prostaglandin E synthase-1, and cardiovascular function. J Clin Invest. 2006;116:1391-9 pubmed
    ..PGE(2) biosynthesis is catalyzed by the coordinate actions of COX enzymes and microsomal PGE synthase-1 (mPGES-1)...
  7. Murakami M, Nakashima K, Kamei D, Masuda S, Ishikawa Y, Ishii T, et al. Cellular prostaglandin E2 production by membrane-bound prostaglandin E synthase-2 via both cyclooxygenases-1 and -2. J Biol Chem. 2003;278:37937-47 pubmed
    ..evidence suggests that two forms of prostaglandin (PG) E synthase (PGES), cytosolic PGES and membrane-bound PGES (mPGES) -1, preferentially lie downstream of cyclooxygenase (COX) -1 and -2, respectively, in the PGE2 biosynthetic ..
  8. Trebino C, Stock J, Gibbons C, Naiman B, Wachtmann T, Umland J, et al. Impaired inflammatory and pain responses in mice lacking an inducible prostaglandin E synthase. Proc Natl Acad Sci U S A. 2003;100:9044-9 pubmed
    ..These findings suggest that mPGES1 provides a target for the treatment of inflammatory diseases and pain associated with inflammatory states. ..
  9. Jia Z, Wang H, Yang T. Mice lacking mPGES-1 are resistant to lithium-induced polyuria. Am J Physiol Renal Physiol. 2009;297:F1689-96 pubmed publisher
    ..The present study was undertaken to assess lithium-induced polyuria in mice deficient in microsomal prostaglandin E synthase-1 (mPGES-1). A 2-wk administration of LiCl (4 mmol.kg(-1)...
  10. Boulet L, Ouellet M, Bateman K, Ethier D, Percival M, Riendeau D, et al. Deletion of microsomal prostaglandin E2 (PGE2) synthase-1 reduces inducible and basal PGE2 production and alters the gastric prostanoid profile. J Biol Chem. 2004;279:23229-37 pubmed
    Microsomal prostaglandin E synthase-1 (mPGES-1) is an inducible protein recently shown to be an important source of inflammatory PGE2...

Detail Information

Publications82

  1. Guan Y, Zhang Y, Schneider A, Riendeau D, Mancini J, Davis L, et al. Urogenital distribution of a mouse membrane-associated prostaglandin E(2) synthase. Am J Physiol Renal Physiol. 2001;281:F1173-7 pubmed
    ..In the present studies, we report the functional expression of a membrane-associated murine PGES (mPGES) and its expression in urogenital tissues...
  2. Jia Z, Guo X, Zhang H, Wang M, Dong Z, Yang T. Microsomal prostaglandin synthase-1-derived prostaglandin E2 protects against angiotensin II-induced hypertension via inhibition of oxidative stress. Hypertension. 2008;52:952-9 pubmed publisher
    ..The present study examined the role and mechanism of microsomal PG synthase-1 (mPGES-1) in vascular response to angiotensin II (Ang II) infusion. A 7-day Ang II infusion at 0...
  3. Elander N, Ungerbäck J, Olsson H, Uematsu S, Akira S, Soderkvist P. Genetic deletion of mPGES-1 accelerates intestinal tumorigenesis in APC(Min/+) mice. Biochem Biophys Res Commun. 2008;372:249-53 pubmed publisher
    ..Here we demonstrate that APC(Min/+) mice with genetic deletion of microsomal prostaglandin E synthase-1 (mPGES-1), which catalyses the terminal conversion of PGH(2) into PGE(2), surprisingly develop more and ..
  4. Jia Z, Aoyagi T, Kohan D, Yang T. mPGES-1 deletion impairs aldosterone escape and enhances sodium appetite. Am J Physiol Renal Physiol. 2010;299:F155-66 pubmed publisher
    ..Here, we investigated the role of microsomal prostaglandin E synthase-1 (mPGES-1) in the response to excess Aldo. A 14-day Aldo infusion at 0...
  5. Monrad S, Kojima F, Kapoor M, Kuan E, Sarkar S, Randolph G, et al. Genetic deletion of mPGES-1 abolishes PGE2 production in murine dendritic cells and alters the cytokine profile, but does not affect maturation or migration. Prostaglandins Leukot Essent Fatty Acids. 2011;84:113-21 pubmed publisher
    We undertook this study to determine the role of Microsomal PGE Synthase-1 (mPGES-1), and mPGES-1-generated Prostaglandin (PG) E2 on Dendritic Cell (DC) phenotype and function...
  6. Cheng Y, Wang M, Yu Y, Lawson J, Funk C, Fitzgerald G. Cyclooxygenases, microsomal prostaglandin E synthase-1, and cardiovascular function. J Clin Invest. 2006;116:1391-9 pubmed
    ..PGE(2) biosynthesis is catalyzed by the coordinate actions of COX enzymes and microsomal PGE synthase-1 (mPGES-1)...
  7. Murakami M, Nakashima K, Kamei D, Masuda S, Ishikawa Y, Ishii T, et al. Cellular prostaglandin E2 production by membrane-bound prostaglandin E synthase-2 via both cyclooxygenases-1 and -2. J Biol Chem. 2003;278:37937-47 pubmed
    ..evidence suggests that two forms of prostaglandin (PG) E synthase (PGES), cytosolic PGES and membrane-bound PGES (mPGES) -1, preferentially lie downstream of cyclooxygenase (COX) -1 and -2, respectively, in the PGE2 biosynthetic ..
  8. Trebino C, Stock J, Gibbons C, Naiman B, Wachtmann T, Umland J, et al. Impaired inflammatory and pain responses in mice lacking an inducible prostaglandin E synthase. Proc Natl Acad Sci U S A. 2003;100:9044-9 pubmed
    ..These findings suggest that mPGES1 provides a target for the treatment of inflammatory diseases and pain associated with inflammatory states. ..
  9. Jia Z, Wang H, Yang T. Mice lacking mPGES-1 are resistant to lithium-induced polyuria. Am J Physiol Renal Physiol. 2009;297:F1689-96 pubmed publisher
    ..The present study was undertaken to assess lithium-induced polyuria in mice deficient in microsomal prostaglandin E synthase-1 (mPGES-1). A 2-wk administration of LiCl (4 mmol.kg(-1)...
  10. Boulet L, Ouellet M, Bateman K, Ethier D, Percival M, Riendeau D, et al. Deletion of microsomal prostaglandin E2 (PGE2) synthase-1 reduces inducible and basal PGE2 production and alters the gastric prostanoid profile. J Biol Chem. 2004;279:23229-37 pubmed
    Microsomal prostaglandin E synthase-1 (mPGES-1) is an inducible protein recently shown to be an important source of inflammatory PGE2...
  11. Kamei D, Yamakawa K, Takegoshi Y, Mikami Nakanishi M, Nakatani Y, Oh Ishi S, et al. Reduced pain hypersensitivity and inflammation in mice lacking microsomal prostaglandin e synthase-1. J Biol Chem. 2004;279:33684-95 pubmed
    We examined the in vivo role of membrane-bound prostaglandin E synthase (mPGES)-1, a terminal enzyme in the PGE2-biosynthetic pathway, using mPGES-1 knockout (KO) mice...
  12. Francois H, Facemire C, Kumar A, Audoly L, Koller B, Coffman T. Role of microsomal prostaglandin E synthase 1 in the kidney. J Am Soc Nephrol. 2007;18:1466-75 pubmed
    ..PGE(2) is generated through enzymatic metabolism of prostanoid endoperoxides by specific PGE synthases (PGES)...
  13. Wang M, Zukas A, Hui Y, Ricciotti E, Pure E, Fitzgerald G. Deletion of microsomal prostaglandin E synthase-1 augments prostacyclin and retards atherogenesis. Proc Natl Acad Sci U S A. 2006;103:14507-12 pubmed
    Prostaglandin (PG) E(2) is formed from PGH(2) by a series of PGE synthase (PGES) enzymes. Microsomal PGES-1(-/-) (mPGES-1(-/-)) mice were crossed into low-density lipoprotein receptor knockout (LDLR(-/-)) mice to generate mPGES-1(-/-) ..
  14. Jia Z, Wang N, Aoyagi T, Wang H, Liu H, Yang T. Amelioration of cisplatin nephrotoxicity by genetic or pharmacologic blockade of prostaglandin synthesis. Kidney Int. 2011;79:77-88 pubmed publisher
    ..injury, inflammation, oxidative stress, and arachidonate metabolism were all diminished in microsomal prostaglandin E synthase-1 (mPGES-1) null mice; a phenotype recapitulated by treatment of wild-type mice with the COX-2 inhibitor ..
  15. Hofstetter A, Saha S, Siljehav V, Jakobsson P, Herlenius E. The induced prostaglandin E2 pathway is a key regulator of the respiratory response to infection and hypoxia in neonates. Proc Natl Acad Sci U S A. 2007;104:9894-9 pubmed
    ..IL-1beta and transient anoxia rapidly induced brainstem-specific microsomal prostaglandin E synthase-1 (mPGES-1) activity in neonatal mice...
  16. Jia Z, Zhang A, Zhang H, Dong Z, Yang T. Deletion of microsomal prostaglandin E synthase-1 increases sensitivity to salt loading and angiotensin II infusion. Circ Res. 2006;99:1243-51 pubmed
    Microsomal prostaglandin E synthase-1 (mPGES-1), a membrane-associated protein, is critically involved in the inflammatory response and may be involved in physiological processes as well...
  17. Schneider A, Zhang Y, Zhang M, Lu W, Rao R, Fan X, et al. Membrane-associated PGE synthase-1 (mPGES-1) is coexpressed with both COX-1 and COX-2 in the kidney. Kidney Int. 2004;65:1205-13 pubmed
    ..The present studies were aimed at determining the intrarenal localization of mPGES-1 and whether it is coexpressed with COX-1 or COX-2...
  18. Kapoor M, Kojima F, Qian M, Yang L, Crofford L. Shunting of prostanoid biosynthesis in microsomal prostaglandin E synthase-1 null embryo fibroblasts: regulatory effects on inducible nitric oxide synthase expression and nitrite synthesis. FASEB J. 2006;20:2387-9 pubmed
    Microsomal prostaglandin (PG) E synthase (mPGES)-1 is an inducible enzyme that acts downstream of cyclooxygenase (COX) and specifically catalyzes the conversion of prostaglandin (PG)H2 to PGE2, most prominently in inflammatory conditions...
  19. Saha S, Engström L, Mackerlova L, Jakobsson P, Blomqvist A. Impaired febrile responses to immune challenge in mice deficient in microsomal prostaglandin E synthase-1. Am J Physiol Regul Integr Comp Physiol. 2005;288:R1100-7 pubmed
    ..modified mice, we examined the role of the inducible terminal PGE2-synthesizing enzyme microsomal prostaglandin E synthase-1 (mPGES-1) for the generation of immune-elicited fever...
  20. Murakami M, Naraba H, Tanioka T, Semmyo N, Nakatani Y, Kojima F, et al. Regulation of prostaglandin E2 biosynthesis by inducible membrane-associated prostaglandin E2 synthase that acts in concert with cyclooxygenase-2. J Biol Chem. 2000;275:32783-92 pubmed
    ..the molecular identification of membrane-bound glutathione (GSH)-dependent prostaglandin (PG) E(2) synthase (mPGES), a terminal enzyme of the cyclooxygenase (COX)-2-mediated PGE(2) biosynthetic pathway...
  21. Oshima H, Oshima M, Inaba K, Taketo M. Hyperplastic gastric tumors induced by activated macrophages in COX-2/mPGES-1 transgenic mice. EMBO J. 2004;23:1669-78 pubmed
    ..in gastric tumorigenesis, we constructed transgenic mice simultaneously expressing COX-2 and microsomal prostaglandin E synthase (mPGES)-1 in the gastric epithelial cells...
  22. Uematsu S, Matsumoto M, Takeda K, Akira S. Lipopolysaccharide-dependent prostaglandin E(2) production is regulated by the glutathione-dependent prostaglandin E(2) synthase gene induced by the Toll-like receptor 4/MyD88/NF-IL6 pathway. J Immunol. 2002;168:5811-6 pubmed
    ..Membrane-bound glutathione-dependent PGE(2) synthase (mPGES) has been shown to be a terminal enzyme of the cyclooxygenase-2-mediated PGE(2) biosynthesis...
  23. Soodvilai S, Jia Z, Wang M, Dong Z, Yang T. mPGES-1 deletion impairs diuretic response to acute water loading. Am J Physiol Renal Physiol. 2009;296:F1129-35 pubmed publisher
    ..The present study was undertaken to examine the role of microsomal prostaglandin E synthase-1 (mPGES-1) in the diuretic response to acute and chronic water loading...
  24. Kojima F, Kapoor M, Yang L, Fleishaker E, Ward M, Monrad S, et al. Defective generation of a humoral immune response is associated with a reduced incidence and severity of collagen-induced arthritis in microsomal prostaglandin E synthase-1 null mice. J Immunol. 2008;180:8361-8 pubmed
    Microsomal PGE synthase-1 (mPGES-1) is an inducible enzyme that acts downstream of cyclooxygenase and specifically catalyzes the conversion of PGH(2) to PGE(2)...
  25. Nakanishi M, Montrose D, Clark P, Nambiar P, Belinsky G, Claffey K, et al. Genetic deletion of mPGES-1 suppresses intestinal tumorigenesis. Cancer Res. 2008;68:3251-9 pubmed publisher
    ..study, we evaluated the chemopreventive efficacy of targeting the terminal synthase microsomal PGE(2) synthase 1 (mPGES-1), which is responsible for generating PGE(2), in two murine models of intestinal cancer...
  26. Degousee N, Angoulvant D, Fazel S, Stefanski E, Saha S, Iliescu K, et al. c-Jun N-terminal kinase-mediated stabilization of microsomal prostaglandin E2 synthase-1 mRNA regulates delayed microsomal prostaglandin E2 synthase-1 expression and prostaglandin E2 biosynthesis by cardiomyocytes. J Biol Chem. 2006;281:16443-52 pubmed
    Microsomal prostaglandin (PG) E(2) synthase-1 (mPGES-1) catalyzes the terminal step in the biosynthesis of PGE(2), a key proinflammatory mediator...
  27. Parazzoli S, Harmon J, VALLERIE S, Zhang T, Zhou H, Robertson R. Cyclooxygenase-2, not microsomal prostaglandin E synthase-1, is the mechanism for interleukin-1?-induced prostaglandin E2 production and inhibition of insulin secretion in pancreatic islets. J Biol Chem. 2012;287:32246-53 pubmed publisher
    ..by two isoenzyme groups, cyclooxygenases (COX-1 and COX-2) and terminal prostaglandin E synthases (cPGES, mPGES-1, and mPGES-2). mPGES-1 is widely considered to be the final enzyme regulating COX-2-dependent PGE(2) synthesis...
  28. Chandrasekharan S, Foley N, Jania L, Clark P, Audoly L, Koller B. Coupling of COX-1 to mPGES1 for prostaglandin E2 biosynthesis in the murine mammary gland. J Lipid Res. 2005;46:2636-48 pubmed
    ..We thus provide evidence for the first time of functional coupling between COX-1 and mPGES1 in the murine mammary gland in vivo. ..
  29. Kuroda E, Ishii K, Uematsu S, Ohata K, Coban C, Akira S, et al. Silica crystals and aluminum salts regulate the production of prostaglandin in macrophages via NALP3 inflammasome-independent mechanisms. Immunity. 2011;34:514-26 pubmed publisher
    ..PGE? expression was markedly reduced in PGE synthase-deficient (Ptges?/?) macrophages, and Ptges?/? mice displayed reduced antigen-specific serum IgE concentrations after immunization ..
  30. Dallaporta M, Pecchi E, Jacques C, Berenbaum F, Jean A, Thirion S, et al. c-Fos immunoreactivity induced by intraperitoneal LPS administration is reduced in the brain of mice lacking the microsomal prostaglandin E synthase-1 (mPGES-1). Brain Behav Immun. 2007;21:1109-21 pubmed
    The aim of the present study was to investigate the impact of the deletion of the microsomal prostaglandin E synthase-1 (mPGES-1) gene on lipopolysaccharide (LPS)-induced neuronal activation in central nervous structures...
  31. Chen J, Zhao M, He W, Milne G, Howard J, Morrow J, et al. Increased dietary NaCl induces renal medullary PGE2 production and natriuresis via the EP2 receptor. Am J Physiol Renal Physiol. 2008;295:F818-25 pubmed publisher
    ..Cytosolic prostaglandin E synthase and prostacyclin synthase were not induced by the high-salt diet...
  32. Le Maître E, Revathikumar P, Idborg H, Raouf J, Korotkova M, Jakobsson P, et al. Impaired vagus-mediated immunosuppression in microsomal prostaglandin E synthase-1 deficient mice. Prostaglandins Other Lipid Mediat. 2015;121:155-62 pubmed publisher
    ..The effect of vagus nerve stimulation (VNS) has been evaluated in microsomal prostaglandin E synthase-1 (mPGES-1) knockout (-/-) and wild-type (+/+) mice regarding cytokine and PG levels after ..
  33. Divangahi M, Desjardins D, Nunes Alves C, Remold H, Behar S. Eicosanoid pathways regulate adaptive immunity to Mycobacterium tuberculosis. Nat Immunol. 2010;11:751-8 pubmed publisher
    ..Our results explain why T cell priming in response to M. tuberculosis is delayed and emphasize the importance of early immunity. ..
  34. Abbas H, Maccio D, Coskun S, Jackson J, Hazen A, SILLS T, et al. Mdm2 is required for survival of hematopoietic stem cells/progenitors via dampening of ROS-induced p53 activity. Cell Stem Cell. 2010;7:606-17 pubmed publisher
    ..p16 was also stabilized because of ROS, and its loss increased cell cycling and partially rescued hematopoiesis and survival. Thus, Mdm2 is required to control ROS-induced p53 levels for sustainable hematopoiesis. ..
  35. Takemiya T, Matsumura K, Sugiura H, Yasuda S, Uematsu S, Akira S, et al. Endothelial microsomal prostaglandin E synthase-1 facilitates neurotoxicity by elevating astrocytic Ca2+ levels. Neurochem Int. 2011;58:489-96 pubmed publisher
    ..Recently, we found kainic acid (KA) administration induced microsomal prostaglandin E synthase-1 (mPGES-1) and prostaglandin E(2) (PGE(2)) receptor EP3 in venous endothelia and on astrocytes, ..
  36. García Alonso V, López Vicario C, Titos E, Morán Salvador E, González Périz A, Rius B, et al. Coordinate functional regulation between microsomal prostaglandin E synthase-1 (mPGES-1) and peroxisome proliferator-activated receptor ? (PPAR?) in the conversion of white-to-brown adipocytes. J Biol Chem. 2013;288:28230-42 pubmed publisher
    ..Microsomal prostaglandin E (PGE) synthase-1 (mPGES-1) is an inducible enzyme that couples with cyclooxygenase-2 for the biosynthesis of PGE2...
  37. Inagaki M, Nishimura T, Akanuma S, Nakanishi T, Tachikawa M, Tamai I, et al. Co-localization of microsomal prostaglandin E synthase-1 with cyclooxygenase-1 in layer II of murine placental syncytiotrophoblasts. Placenta. 2017;53:76-82 pubmed publisher
    ..Placental PGE2 synthesis might be mediated by microsomal PGE synthase-1 (mPGES-1), in addition to cyclooxygenase (COX) isoforms...
  38. Kamei D, Murakami M, Sasaki Y, Nakatani Y, Majima M, Ishikawa Y, et al. Microsomal prostaglandin E synthase-1 in both cancer cells and hosts contributes to tumour growth, invasion and metastasis. Biochem J. 2009;425:361-71 pubmed publisher
    mPGES-1 (microsomal prostaglandin E synthase-1) is a stimulus-inducible enzyme that functions downstream of COX (cyclo-oxygenase)-2 in the PGE2 (prostaglandin E2)-biosynthesis pathway...
  39. Gosset M, Berenbaum F, Levy A, Pigenet A, Thirion S, Saffar J, et al. Prostaglandin E2 synthesis in cartilage explants under compression: mPGES-1 is a mechanosensitive gene. Arthritis Res Ther. 2006;8:R135 pubmed
    ..Its synthesis is the result of cyclooxygenase (COX) and prostaglandin E synthase (PGES) activities whereas NAD+-dependent 15 hydroxy prostaglandin dehydrogenase (15-PGDH) is the key ..
  40. Matsuda H, Hosono K, Tsuru S, Kurashige C, Sekiguchi K, Akira S, et al. Roles of mPGES-1, an inducible prostaglandin E synthase, in enhancement of LPS-induced lymphangiogenesis in a mouse peritonitis model. Life Sci. 2015;142:1-7 pubmed publisher
    ..We explored the roles of an inducible prostaglandin E synthase, mPGES-1, in IL elicited by lipopolysaccharide (LPS)...
  41. Hartney J, Coggins K, Tilley S, Jania L, Lovgren A, Audoly L, et al. Prostaglandin E2 protects lower airways against bronchoconstriction. Am J Physiol Lung Cell Mol Physiol. 2006;290:L105-13 pubmed
    ..Hpgd-/-), the major catabolic enzyme of PGE2, and by generating a transgenic line in which mouse PGE2 synthase (Ptges) expression is driven by a human lung-specific promoter, hSP-C...
  42. Ikeda Matsuo Y, Ota A, Fukada T, Uematsu S, Akira S, Sasaki Y. Microsomal prostaglandin E synthase-1 is a critical factor of stroke-reperfusion injury. Proc Natl Acad Sci U S A. 2006;103:11790-5 pubmed
    ..Here we demonstrate the induction of microsomal PGE synthase 1 (mPGES-1), an inducible terminal enzyme for PGE(2) synthesis, in neurons, microglia, and endothelial cells in the ..
  43. Díaz Muñoz M, Osma García I, Fresno M, Iñiguez M. Involvement of PGE2 and the cAMP signalling pathway in the up-regulation of COX-2 and mPGES-1 expression in LPS-activated macrophages. Biochem J. 2012;443:451-61 pubmed publisher
    ..In the present study, we describe a PGE2 positive feedback for COX (cyclo-oxygenase)-2 and mPGES-1 [microsomal PGES (PGE synthase)-1] expression in the macrophage cell line RAW 264.7...
  44. Eskilsson A, Tachikawa M, Hosoya K, Blomqvist A. Distribution of microsomal prostaglandin E synthase-1 in the mouse brain. J Comp Neurol. 2014;522:3229-44 pubmed publisher
    Previous studies in rats have demonstrated that microsomal prostaglandin E synthase-1 (mPGES-1) is induced in brain vascular cells that also express inducible cyclooxygenase-2, suggesting that such cells are the source of the increased ..
  45. Degousee N, Fazel S, Angoulvant D, Stefanski E, Pawelzik S, Korotkova M, et al. Microsomal prostaglandin E2 synthase-1 deletion leads to adverse left ventricular remodeling after myocardial infarction. Circulation. 2008;117:1701-10 pubmed publisher
    ..Microsomal prostaglandin (PG) E(2) synthase-1 (mPGES-1), encoded by the Ptges gene, functions downstream from cyclooxygenase-2 in the inducible PGE(2) biosynthetic ..
  46. Barakat W, Herrmann O, Baumann B, Schwaninger M. NF-kappaB induces PGE2-synthesizing enzymes in neurons. Naunyn Schmiedebergs Arch Pharmacol. 2009;380:153-60 pubmed publisher
    ..cytosolic phospholipase A-2 (cPLA-2), cyclooxygenase-2 (COX-2), and microsomal prostaglandin E(2) synthase-1 (mPGES-1), three genes that are involved in the synthesis of prostaglandin E(2) (PGE(2))...
  47. Shiro T, Takahashi H, Kakiguchi K, Inoue Y, Masuda K, Nagata H, et al. Synthesis and SAR study of imidazoquinolines as a novel structural class of microsomal prostaglandin E? synthase-1 inhibitors. Bioorg Med Chem Lett. 2012;22:285-8 pubmed publisher
    The imidazoquinoline derivative 1 was found as a novel mPGES-1 inhibitor. Optimization of 1 led to the identification of the 2-chlorophenyl group at the C(2)-position and the quinolone structure at the C(4)-position...
  48. Lazarus M, Kubata B, Eguchi N, Fujitani Y, Urade Y, Hayaishi O. Biochemical characterization of mouse microsomal prostaglandin E synthase-1 and its colocalization with cyclooxygenase-2 in peritoneal macrophages. Arch Biochem Biophys. 2002;397:336-41 pubmed
    We cloned the cDNA for mouse microsomal prostaglandin (PG) E synthase-1 (mPGES-1) and expressed the recombinant enzyme in Escherichia coli...
  49. Aghourian M, Lemarié C, Bertin F, Blostein M. Prostaglandin E synthase is upregulated by Gas6 during cancer-induced venous thrombosis. Blood. 2016;127:769-77 pubmed publisher
    ..WT and Gas6(-/-) endothelial cells exposed to M27 murine lung carcinoma cells reveal that Gas6 increases prostaglandin E synthase (Ptges) expression in endothelial cells...
  50. Tamura K, Naraba H, Hara T, Nakamura K, Yoshie M, Kogo H, et al. A positive feedback loop between progesterone and microsomal prostaglandin E synthase-1-mediated PGE2 promotes production of both in mouse granulosa cells. Prostaglandins Other Lipid Mediat. 2016;123:56-62 pubmed publisher
    Microsomal prostaglandin E synthase-1 (mPGES-1) is primarily expressed in granulosa cells (GCs) in the preovulatory follicle. Both prostaglandin E2 (PGE2) and progesterone (P4) are implicated in various reproductive functions...
  51. Tang S, Monslow J, R Grant G, Todd L, Pawelzik S, Chen L, et al. Cardiovascular Consequences of Prostanoid I Receptor Deletion in Microsomal Prostaglandin E Synthase-1-Deficient Hyperlipidemic Mice. Circulation. 2016;134:328-38 pubmed publisher
    ..By contrast, deletion of microsomal prostaglandin E synthase 1 (mPGES-1) confers analgesia, attenuates atherogenesis, and fails to accelerate thrombogenesis, ..
  52. Wu D, Mennerich D, Arndt K, Sugiyama K, Ozaki N, Schwarz K, et al. Comparison of microsomal prostaglandin E synthase-1 deletion and COX-2 inhibition in acute cardiac ischemia in mice. Prostaglandins Other Lipid Mediat. 2009;90:21-5 pubmed publisher
    The aim of the present study was to compare the effects of genetic mPGES-1 loss and COX-2 inhibition on myocardial damage after coronary occlusion...
  53. Khan K, Kothari P, Du B, Dannenberg A, Falcone D. Matrix metalloproteinase-dependent microsomal prostaglandin E synthase-1 expression in macrophages: role of TNF-? and the EP4 prostanoid receptor. J Immunol. 2012;188:1970-80 pubmed publisher
    ..study, we determined whether MMP-induced cyclooxygenase-2 expression was coupled to the expression of prostaglandin E synthase family members...
  54. Facemire C, Nguyen M, Jania L, Beierwaltes W, Kim H, Koller B, et al. A major role for the EP4 receptor in regulation of renin. Am J Physiol Renal Physiol. 2011;301:F1035-41 pubmed publisher
    ..Surprisingly, mPGES1 or mPGES2 are not required, suggesting other alternative mechanisms for generating PGE(2) in response to macula densa stimulation. ..
  55. Lazarus M, Munday C, Eguchi N, Matsumoto S, Killian G, Kubata B, et al. Immunohistochemical localization of microsomal PGE synthase-1 and cyclooxygenases in male mouse reproductive organs. Endocrinology. 2002;143:2410-9 pubmed
    We investigated the tissue distribution and cellular localization of microsomal PGE synthase-1 (mPGES-1) and cyclooxygenase (COX)-1 and -2 in the male mouse reproductive organs...
  56. Nagamachi M, Sakata D, Kabashima K, Furuyashiki T, Murata T, Segi Nishida E, et al. Facilitation of Th1-mediated immune response by prostaglandin E receptor EP1. J Exp Med. 2007;204:2865-74 pubmed
    ..These results suggest that PGE2 produced by dendritic cells in the lymph nodes acts on EP1 in naive T cells to promote Th1 differentiation. ..
  57. Takahashi R, Amano H, Satoh T, Tabata K, Ikeda M, Kitasato H, et al. Roles of microsomal prostaglandin E synthase-1 in lung metastasis formation in prostate cancer RM9 cells. Biomed Pharmacother. 2014;68:71-7 pubmed publisher
    ..We have previously reported that host stromal microsomal prostaglandin E synthase-1 (mPGES-1) appeared critical for tumor-associated angiogenesis and tumor growth...
  58. Yamakawa K, Kamekura S, Kawamura N, Saegusa M, Kamei D, Murakami M, et al. Association of microsomal prostaglandin E synthase 1 deficiency with impaired fracture healing, but not with bone loss or osteoarthritis, in mouse models of skeletal disorders. Arthritis Rheum. 2008;58:172-83 pubmed publisher
    b>Prostaglandin E synthase (PGES) functions as the terminal enzyme in the biosynthesis of prostaglandin E(2) (PGE(2)) and is a potent regulator of bone and cartilage metabolism...
  59. Yao L, Chen W, Han C, Wu T. Microsomal prostaglandin E synthase-1 protects against Fas-induced liver injury. Am J Physiol Gastrointest Liver Physiol. 2016;310:G1071-80 pubmed publisher
    Microsomal prostaglandin E synthase-1 (mPGES-1) is the terminal enzyme for the synthesis of prostaglandin E2 (PGE2), a proproliferative and antiapoptotic lipid molecule important for tissue regeneration and injury repair...
  60. Siljehav V, Olsson Hofstetter A, Jakobsson P, Herlenius E. mPGES-1 and prostaglandin E2: vital role in inflammation, hypoxic response, and survival. Pediatr Res. 2012;72:460-7 pubmed publisher
    ..We hypothesize that alteration of the microsomal PGE synthase-1 (mPGES-1) PGE(2) pathway influences respiratory control and response to hypoxia...
  61. Wang M, Lee E, Song W, Ricciotti E, Rader D, Lawson J, et al. Microsomal prostaglandin E synthase-1 deletion suppresses oxidative stress and angiotensin II-induced abdominal aortic aneurysm formation. Circulation. 2008;117:1302-9 pubmed publisher
    Microsomal prostaglandin (PG) E(2) synthase-1 (mPGES-1) catalyzes isomerization of the cyclooxygenase product PGH(2) into PGE(2). Deletion of mPGES-1 modulates experimentally evoked pain and inflammation and retards atherogenesis...
  62. Kihara Y, Matsushita T, Kita Y, Uematsu S, Akira S, Kira J, et al. Targeted lipidomics reveals mPGES-1-PGE2 as a therapeutic target for multiple sclerosis. Proc Natl Acad Sci U S A. 2009;106:21807-12 pubmed publisher
    ..Here, using an AA cascade-targeted lipidomics approach, we report that microsomal PGE synthase 1 (mPGES-1) plays a key role in experimental autoimmune encephalomyelitis (EAE)...
  63. Peña Silva R, Mitchell I, Kung D, Pewe L, Granja M, Harty J, et al. Paradoxical Increase in Mortality and Rupture of Intracranial Aneurysms in Microsomal Prostaglandin E2 Synthase Type 1-Deficient Mice: Attenuation by Aspirin. Neurosurgery. 2015;77:613-20 pubmed publisher
    ..Expression of microsomal prostaglandin E2 (PGE2) synthase type 1 (mPGES-1) is increased in the wall of intracranial aneurysms in humans...
  64. Gosset M, Pigenet A, Salvat C, Berenbaum F, Jacques C. Inhibition of matrix metalloproteinase-3 and -13 synthesis induced by IL-1beta in chondrocytes from mice lacking microsomal prostaglandin E synthase-1. J Immunol. 2010;185:6244-52 pubmed publisher
    ..the role of PGE(2) on MMP synthesis in articular chondrocytes using mice lacking microsomal PGE synthase-1 (mPGES-1), which catalyses the rate-limiting step of PGE(2) synthesis...
  65. Ni H, Sun T, Ma X, Yang Z. Expression and regulation of cytosolic prostaglandin E synthase in mouse uterus during the peri-implantation period. Biol Reprod. 2003;68:744-50 pubmed
    ..PGE synthase (PGES) catalyzes the isomerization of PGH(2) to PGE(2). Two isoforms of PGES exist: microsomal PGES (mPGES) and cytosolic PGES (cPGES); however, the expression and regulation of cPGES in the mammalian uterus during early ..
  66. Ae T, Ohno T, Hattori Y, Suzuki T, Hosono K, Minamino T, et al. Role of microsomal prostaglandin E synthase-1 in the facilitation of angiogenesis and the healing of gastric ulcers. Am J Physiol Gastrointest Liver Physiol. 2010;299:G1139-46 pubmed publisher
    ..However, there has been no report on the functional relevance of microsomal PGES-1 (mPGES-1) to the physiological healing processes of gastric ulcers, or to angiogenesis, which is indispensable to the ..
  67. Jia Z, Liu G, Downton M, Dong Z, Zhang A, Yang T. mPGES-1 deletion potentiates urine concentrating capability after water deprivation. Am J Physiol Renal Physiol. 2012;302:F1005-12 pubmed publisher
    ..The present study was undertaken to investigate the potential role of microsomal PGE synthase (mPGES)-1 in the regulation of urine concentrating ability after water deprivation (WD)...
  68. Wang M, Ihida Stansbury K, Kothapalli D, Tamby M, Yu Z, Chen L, et al. Microsomal prostaglandin e2 synthase-1 modulates the response to vascular injury. Circulation. 2011;123:631-9 pubmed publisher
    ..Previous studies in mice suggest that targeting mPGES-1 may be less likely to cause hypertension or thrombosis than cyclooxygenase-2-selective inhibition or deletion in ..
  69. Samuchiwal S, Balestrieri B, Raff H, Boyce J. Endogenous prostaglandin E2 amplifies IL-33 production by macrophages through an E prostanoid (EP)2/EP4-cAMP-EPAC-dependent pathway. J Biol Chem. 2017;292:8195-8206 pubmed publisher
    ..prostaglandin E2 (PGE2) through inducible COX-2 and microsomal PGE2 synthase 1 (mPGES-1) (1)...
  70. Oshima H, Taketo M, Oshima M. Destruction of pancreatic beta-cells by transgenic induction of prostaglandin E2 in the islets. J Biol Chem. 2006;281:29330-6 pubmed
    ..beta-cells, we generated transgenic mice (RIP-C2mE) that express cyclooxygenase-2 and microsomal prostaglandin E synthase-1 in their beta-cells using the rat insulin-2 gene promoter (RIP)...
  71. Liu T, Laidlaw T, Katz H, Boyce J. Prostaglandin E2 deficiency causes a phenotype of aspirin sensitivity that depends on platelets and cysteinyl leukotrienes. Proc Natl Acad Sci U S A. 2013;110:16987-92 pubmed publisher
    ..The findings suggest applications of antiplatelet drugs or TP receptor antagonists for the treatment of AERD. ..
  72. Ni H, Sun T, Ding N, Ma X, Yang Z. Differential expression of microsomal prostaglandin e synthase at implantation sites and in decidual cells of mouse uterus. Biol Reprod. 2002;67:351-8 pubmed
    ..There are two isoforms of PGES, microsomal PGES (mPGES) and cytosolic PGES (cPGES)...
  73. Brenneis C, Coste O, Altenrath K, Angioni C, Schmidt H, Schuh C, et al. Anti-inflammatory role of microsomal prostaglandin E synthase-1 in a model of neuroinflammation. J Biol Chem. 2011;286:2331-42 pubmed publisher
    ..Here, we investigated the role of microsomal PGE(2) synthase-1 (mPGES-1), which is functionally coupled to COX-2, in immune responses using a model of lipopolysaccharide (LPS)-induced ..
  74. Ueno N, Taketomi Y, Yamamoto K, Hirabayashi T, Kamei D, Kita Y, et al. Analysis of two major intracellular phospholipases A(2) (PLA(2)) in mast cells reveals crucial contribution of cytosolic PLA(2)?, not Ca(2+)-independent PLA(2)?, to lipid mobilization in proximal mast cells and distal fibroblasts. J Biol Chem. 2011;286:37249-63 pubmed publisher
    ..the AA released by cPLA(2)? from BMMCs during maturation was converted to PGE(2) by microsomal PGE synthase-1 (mPGES-1) in cocultured fibroblasts, and accordingly, Pla2g4a(-/-) BMMCs promoted microenvironmental PGE(2) synthesis ..
  75. Sugita K, Ikenouchi Sugita A, Nakayama Y, Yoshioka H, Nomura T, Sakabe J, et al. Prostaglandin E? is critical for the development of niacin-deficiency-induced photosensitivity via ROS production. Sci Rep. 2013;3:2973 pubmed publisher
    ..In addition, niacin deficient mice exhibited elevated expressions of COX-2 and PGE syntheses (Ptges) mRNA...
  76. Murase R, Sato H, Yamamoto K, Ushida A, Nishito Y, Ikeda K, et al. Group X Secreted Phospholipase A2 Releases ω3 Polyunsaturated Fatty Acids, Suppresses Colitis, and Promotes Sperm Fertility. J Biol Chem. 2016;291:6895-911 pubmed publisher
  77. Yoshioka W, Aida Yasuoka K, Fujisawa N, Kawaguchi T, Ohsako S, Hara S, et al. Critical role of microsomal prostaglandin E synthase-1 in the hydronephrosis caused by lactational exposure to dioxin in mice. Toxicol Sci. 2012;127:547-54 pubmed publisher
    ..In this study, we investigated the role of microsomal prostaglandin E synthase-1 (mPGES-1), an inducible form of PGE(2) synthase, in TCDD-induced hydronephrosis...
  78. Donnini S, Finetti F, Terzuoli E, Giachetti A, Iniguez M, Hanaka H, et al. EGFR signaling upregulates expression of microsomal prostaglandin E synthase-1 in cancer cells leading to enhanced tumorigenicity. Oncogene. 2012;31:3457-66 pubmed publisher
    ..the contribution of prostaglandin E(2) (PGE(2)) derived from the inducible microsomal PGE-synthase type-1 (mPGES-1) to the epidermal growth factor receptor (EGFR) oncogenic drive in tumor epithelial cells and in tumor-bearing ..
  79. Idborg H, Olsson P, Leclerc P, Raouf J, Jakobsson P, Korotkova M. Effects of mPGES-1 deletion on eicosanoid and fatty acid profiles in mice. Prostaglandins Other Lipid Mediat. 2013;107:18-25 pubmed publisher
    b>mPGES-1 is considered an alternative target for anti-inflammatory treatment with improved selectivity and safety compared to NSAIDs...