Ptger2

Summary

Gene Symbol: Ptger2
Description: prostaglandin E receptor 2 (subtype EP2)
Alias: EP2, Ptgerep2, prostaglandin E2 receptor EP2 subtype, EP2 receptor, PGE receptor EP2 subtype, PGE2 receptor EP2 subtype, prostaglandin E receptor 2 (EP2 subtype), prostaglandin E receptor EP2 subtype, prostaglandin E receptor subtype EP2, prostanoid EP2 receptor
Species: mouse

Top Publications

  1. pmc Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling
    Katia Boniface
    Department of Immunology, Schering Plough Biopharma, Palo Alto, CA 94304, USA
    J Exp Med 206:535-48. 2009
  2. ncbi Insight into prostaglandin, leukotriene, and other eicosanoid functions using mice with targeted gene disruptions
    S C Austin
    Center for Experimental Therapeutics, Stellar Chance Labs, University of Pennsylvania, Philadelphia 19104, USA
    Prostaglandins Other Lipid Mediat 58:231-52. 1999
  3. ncbi Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3
    F Ushikubi
    Department of Pharmacology, Faculty of Medicine, Kyoto University, Japan
    Nature 395:281-4. 1998
  4. ncbi Salt-sensitive hypertension and reduced fertility in mice lacking the prostaglandin EP2 receptor
    C R Kennedy
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2372, USA
    Nat Med 5:217-20. 1999
  5. pmc Reproductive failure and reduced blood pressure in mice lacking the EP2 prostaglandin E2 receptor
    S L Tilley
    Department of Medicine, University of North Carolina Chapel Hill, Chapel Hill, North Carolina 27599 7248, USA
    J Clin Invest 103:1539-45. 1999
  6. pmc Abortive expansion of the cumulus and impaired fertility in mice lacking the prostaglandin E receptor subtype EP(2)
    H Hizaki
    Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Faculty of Medicine, Kyoto University, Kyoto 606 8501, Japan
    Proc Natl Acad Sci U S A 96:10501-6. 1999
  7. ncbi Prostanoid receptors: structures, properties, and functions
    S Narumiya
    Department of Pharmacology, Kyoto University Faculty of Medicine, Kyoto, Japan
    Physiol Rev 79:1193-226. 1999
  8. ncbi Knockout of the murine prostaglandin EP2 receptor impairs osteoclastogenesis in vitro
    X Li
    Department of Medicine, University of Connecticut Health Center, Farmington 06030, USA
    Endocrinology 141:2054-61. 2000
  9. ncbi Bone biomechanical properties in prostaglandin EP1 and EP2 knockout mice
    M P Akhter
    Osteoporosis Research Center, Creighton University, Omaha, NE 68131, USA
    Bone 29:121-5. 2001
  10. pmc The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut
    Kenji Kabashima
    Department of Pharmacology, Faculty of Medicine, Kyoto University, Kyoto, Japan
    J Clin Invest 109:883-93. 2002

Scientific Experts

Detail Information

Publications118 found, 100 shown here

  1. pmc Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling
    Katia Boniface
    Department of Immunology, Schering Plough Biopharma, Palo Alto, CA 94304, USA
    J Exp Med 206:535-48. 2009
    ..In human purified naive T cells, PGE2 acts via prostaglandin receptor EP2- and EP4-mediated signaling and cyclic AMP pathways to up-regulate IL-23 and IL-1 receptor expression...
  2. ncbi Insight into prostaglandin, leukotriene, and other eicosanoid functions using mice with targeted gene disruptions
    S C Austin
    Center for Experimental Therapeutics, Stellar Chance Labs, University of Pennsylvania, Philadelphia 19104, USA
    Prostaglandins Other Lipid Mediat 58:231-52. 1999
    ..g., receptors for various prostaglandins). This minireview will outline the phenotype of these knockout mice and what has been learned about eicosanoid functions through use of this novel methodology...
  3. ncbi Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3
    F Ushikubi
    Department of Pharmacology, Faculty of Medicine, Kyoto University, Japan
    Nature 395:281-4. 1998
    ..PGE2 acts by interacting with four subtypes of PGE receptor, the EP1, EP2, EP3 and EP4 receptors. Here we generate mice lacking each of these receptors by homologous recombination...
  4. ncbi Salt-sensitive hypertension and reduced fertility in mice lacking the prostaglandin EP2 receptor
    C R Kennedy
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2372, USA
    Nat Med 5:217-20. 1999
    ..To evaluate the physiologic role of the PGE2 EP2 receptor subtype, we created mice with targeted disruption of this gene (EP2-/-)...
  5. pmc Reproductive failure and reduced blood pressure in mice lacking the EP2 prostaglandin E2 receptor
    S L Tilley
    Department of Medicine, University of North Carolina Chapel Hill, Chapel Hill, North Carolina 27599 7248, USA
    J Clin Invest 103:1539-45. 1999
    ..Using mice deficient in 1 of 4 prostaglandin E2 (PGE2) receptors -- specifically, the EP2 receptor -- we show that Ep2(-/-) females are infertile secondary to failure of the released ovum to become fertilized ..
  6. pmc Abortive expansion of the cumulus and impaired fertility in mice lacking the prostaglandin E receptor subtype EP(2)
    H Hizaki
    Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Faculty of Medicine, Kyoto University, Kyoto 606 8501, Japan
    Proc Natl Acad Sci U S A 96:10501-6. 1999
    ..These results indicate that PGE(2) cooperates with gonadotropin to complete cumulus expansion for successful fertilization...
  7. ncbi Prostanoid receptors: structures, properties, and functions
    S Narumiya
    Department of Pharmacology, Kyoto University Faculty of Medicine, Kyoto, Japan
    Physiol Rev 79:1193-226. 1999
    ..In this article, we summarize these findings and attempt to give an overview of the current status of research on the prostanoid receptors...
  8. ncbi Knockout of the murine prostaglandin EP2 receptor impairs osteoclastogenesis in vitro
    X Li
    Department of Medicine, University of Connecticut Health Center, Farmington 06030, USA
    Endocrinology 141:2054-61. 2000
    ..We used cells from mice in which the EP2 receptor had been disrupted to test its role in the formation of TRAP + MNC...
  9. ncbi Bone biomechanical properties in prostaglandin EP1 and EP2 knockout mice
    M P Akhter
    Osteoporosis Research Center, Creighton University, Omaha, NE 68131, USA
    Bone 29:121-5. 2001
    ..The PGE2 influence on bone is mediated through four well-characterized receptors (EP1, EP2, EP3, and EP4)...
  10. pmc The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut
    Kenji Kabashima
    Department of Pharmacology, Faculty of Medicine, Kyoto University, Kyoto, Japan
    J Clin Invest 109:883-93. 2002
    ..Among the prostanoid receptor-deficient mice, only EP4-deficient mice and not mice deficient in either DP, EP1, EP2, EP3, FP, IP, or TP developed severe colitis with 3% DSS treatment, which induced only marginal colitis in wild-..
  11. pmc The role of prostaglandin E2 receptors in the pathogenesis of rheumatoid arthritis
    Jennifer M McCoy
    Pfizer Global Research and Development, Department of Inflammation and Pathology, Groton, Connecticut 06340, USA
    J Clin Invest 110:651-8. 2002
    ..Homozygous deletion of the EP1, EP2, or EP3 receptors did not affect the development of arthritis, whereas EP4 receptor-deficient mice showed decreased ..
  12. pmc Impaired adrenocorticotropic hormone response to bacterial endotoxin in mice deficient in prostaglandin E receptor EP1 and EP3 subtypes
    Yoko Matsuoka
    Department of Pharmacology, Kyoto University Faculty of Medicine, Kyoto 606 8501, Japan
    Proc Natl Acad Sci U S A 100:4132-7. 2003
    ..These findings suggest that EP1- and EP3-mediated neuronal pathways converge at corticotropin-releasing hormone-containing neurons in the PVN to induce HPA axis activation upon sickness...
  13. ncbi Prostaglandin E2-EP4 signaling initiates skin immune responses by promoting migration and maturation of Langerhans cells
    Kenji Kabashima
    Department of Pharmacology, Kyoto University Faculty of Medicine, Kyoto 606 8501, Japan
    Nat Med 9:744-9. 2003
    ..PGE2-EP4 signaling thus facilitates initiation of skin immune responses by promoting the migration and maturation of Langerhans cells...
  14. ncbi Suppression of allergic inflammation by the prostaglandin E receptor subtype EP3
    Tomonori Kunikata
    Department of Pharmacology and Faculty of Medicine and Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606 8501, Japan
    Nat Immunol 6:524-31. 2005
    ..Thus, the PGE(2)-EP3 pathway is an important negative modulator of allergic reactions...
  15. ncbi Prostaglandin E2 receptors EP2 and EP4 are down-regulated during differentiation of mouse osteoclasts from their precursors
    Yasuhiro Kobayashi
    Institute for Oral Science, Matsumoto Dental University, 1780 Hiro oka Gobara, Shiojiri, Nagano 399 0781, Japan
    J Biol Chem 280:24035-42. 2005
    ..Bone marrow macrophage osteoclast precursors expressed PGE2 receptors EP1, EP2, EP3beta, and EP4, and the expression of EP2 and EP4 was down-regulated during osteoclastic differentiation induced ..
  16. ncbi Age-induced reprogramming of mast cell degranulation
    MyTrang Nguyen
    Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA
    J Immunol 175:5701-7. 2005
    ..Therefore, elevated PGE2 levels might provide an important pathway by which mast cells are engaged to participate in inflammatory responses in the elderly patient...
  17. ncbi Prostaglandin E2 is required for ultraviolet B-induced skin inflammation via EP2 and EP4 receptors
    Kenji Kabashima
    Department of Pharmacology, Kyoto University Graduate School of Medicine, Sakyo, Kyoto, Japan
    Lab Invest 87:49-55. 2007
    ..The UV-induced ear swelling at 48 h after exposure was significantly reduced in EP2(-/-), EP4(-/-) or wild-type mice treated with the EP4 antagonist compared to control mice...
  18. ncbi Synthetic prostacyclin analogs differentially regulate macrophage function via distinct analog-receptor binding specificities
    David M Aronoff
    Division of Infectious Diseases, Department of Internal Medicine, University of Michigan Health Systems, Ann Arbor, MI 48109, USA
    J Immunol 178:1628-34. 2007
    ..indicated that this was due in part to the previously unknown ability of treprostinil to stimulate the EP2 receptor. The present investigation for the first time identifies differences in immunoregulatory properties of ..
  19. ncbi Prostaglandin E receptors
    Yukihiko Sugimoto
    Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, Faculty of Medicine, Kyoto University, Kyoto 606 8501, Japan
    J Biol Chem 282:11613-7. 2007
    ..There are four GPCRs responding to PGE(2) designated subtypes EP1, EP2, EP3, and EP4 and multiple splicing isoforms of the subtype EP3...
  20. ncbi Bacterial clearance of Pseudomonas aeruginosa is enhanced by the inhibition of COX-2
    Ruxana T Sadikot
    Department of Veterans Affairs, Jesse Brown VA Hospital, Chicago, IL 60612, USA
    Eur J Immunol 37:1001-9. 2007
    ..Furthermore there was enhanced bacterial clearance in EP2 receptor(-/-) mice compared to the wild-type controls...
  21. pmc Prostaglandin E2 suppresses bacterial killing in alveolar macrophages by inhibiting NADPH oxidase
    Carlos H Serezani
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health Systems, Ann Arbor, Michigan 48109 0642, USA
    Am J Respir Cell Mol Biol 37:562-70. 2007
    ..was blocked by an adenylyl cyclase inhibitor and mimicked by agonists for the stimulatory G protein (G(s))-coupled EP2 and EP4 receptors...
  22. pmc Increased dietary NaCl induces renal medullary PGE2 production and natriuresis via the EP2 receptor
    Jian Chen
    Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Am J Physiol Renal Physiol 295:F818-25. 2008
    ..Renal medullary PGE(2) promotes renal sodium excretion via the EP2 receptor, thereby maintaining normotension in the setting of high salt intake.
  23. pmc Bone marrow stromal cells attenuate sepsis via prostaglandin E(2)-dependent reprogramming of host macrophages to increase their interleukin-10 production
    Krisztian Nemeth
    National Institute of Dental and Craniofacial Research NIDCR, Craniofacial and Skeletal Diseases Branch, NIH, Bethesda, MD 20892, USA
    Nat Med 15:42-9. 2009
    ..reprogram macrophages by releasing prostaglandin E(2) that acts on the macrophages through the prostaglandin EP2 and EP4 receptors...
  24. pmc Prostaglandin E(2) induces fibroblast apoptosis by modulating multiple survival pathways
    Steven K Huang
    Pulmonary and Critical Care Medicine, University of Michigan, 6301 MSRB III, 1150 W Medical Center Dr, Ann Arbor, MI 48109 5642, USA
    FASEB J 23:4317-26. 2009
    ..These proapoptotic actions were dependent on signaling through the EP2/EP4 receptors and by downstream activation of both caspases 8 and 9...
  25. doi Temporal expression of the PGE2 synthetic system in the kidney is associated with the time frame of renal developmental vulnerability to cyclooxygenase-2 inhibition
    Stefanie Frölich
    Institute of Clinical Pharmacology, Johann Wolfgang Goethe University, Theodor Stern Kai 7, Frankfurt, Germany
    Am J Physiol Renal Physiol 303:F209-19. 2012
    ..Studying glomerulogenesis in EP receptor knockout mice revealed a reduction in glomerular size in EP1(-/-), EP2(-/-), and EP4(-/-) mice, supporting the developmental role of PGE(2)...
  26. pmc Differential stem- and progenitor-cell trafficking by prostaglandin E2
    Jonathan Hoggatt
    Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Nature 495:365-9. 2013
    ..These results not only uncover unique regulatory roles for EP4 signalling in HSC retention in the niche, but also define a rapidly translatable strategy to enhance transplantation therapeutically...
  27. ncbi PGE2-mediated upregulation of iNOS in murine breast cancer cells through the activation of EP4 receptors
    Alexander V Timoshenko
    Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario, Canada
    Int J Cancer 108:384-9. 2004
    ....
  28. ncbi Prostaglandin E and prostacyclin receptor expression in tumor and host tissues from MCG 101-bearing mice: a model with prostanoid-related cachexia
    Wenhua Wang
    Surgical Metabolic Research Laboratory at Lundberg Laboratory for Cancer Research, Department of Surgery, Sahlgrenska University Hospital, Goteborg, Sweden
    Int J Cancer 115:582-90. 2005
    ..Expressions of PGE (EP1, EP2, EP3alpha,beta,gamma and EP4) and PGI (IP) receptors in the central nervous system (brain cortex, hypothalamus and ..
  29. ncbi Prostaglandin E2 protects lower airways against bronchoconstriction
    John M Hartney
    Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, NC 27599, USA
    Am J Physiol Lung Cell Mol Physiol 290:L105-13. 2006
    ..mice lacking this synthase (Ptges-/-) and receptors that mediate the actions of PGE2, particularly the PGE2 EP2 receptor (Ptger2)...
  30. doi Increased prostaglandin E₂-EP2 signalling in cumulus cells of female mice sired by males with the Y-chromosome long-arm deletion
    Katarzyna Kotarska
    Department of Genetics and Evolution, Institute of Zoology, Jagiellonian University, Gronostajowa 9, 30 387 Krakow, Poland
    Reprod Fertil Dev 25:900-6. 2013
    ..BR(Y(del)) females display higher surface accumulation of prostaglandin EP2 subtype receptors and higher expression of the Ptgs2 gene (encoding a rate-limiting enzyme of prostaglandin E₂ ..
  31. doi Fluid flow shear stress upregulates prostanoid receptor EP2 but not EP4 in murine podocytes
    Tarak Srivastava
    Section of Nephrology, Children s Mercy Hospital and University of Missouri at Kansas City, Kansas City, MO 64108, USA
    Prostaglandins Other Lipid Mediat 104:49-57. 2013
    ..of RT-PCR, qRT-PCR, immunoblotting and immunofluorescence studies indicate that cultured podocytes express EP1, EP2 and EP4 but not EP3. FFSS resulted in upregulated expression of only EP2 in podocytes...
  32. doi Prostaglandin E2 blockade enhances the pulmonary anti-Cryptococcus neoformans immune reaction via the induction of TLR-4
    Liyun Shen
    Department of Hematology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou 450014, China Electronic address
    Int Immunopharmacol 28:376-81. 2015
    ..forming unit (CFU) assays demonstrated that the cryptococcal infection was dramatically depressed in mice given EP2 and EP4 or single EP antagonist treatment compared to the untreated wild type mice (p<0...
  33. pmc Local abnormalities in coagulation and fibrinolytic pathways predispose to alveolar fibrin deposition in the adult respiratory distress syndrome
    S Idell
    Department of Medicine, University of Texas Health Center, Tyler 75710
    J Clin Invest 84:695-705. 1989
    ..We conclude that abnormalities that result in enhanced coagulation and depressed fibrinolysis, thereby predisposing to alveolar fibrin deposition, occur in the alveolar lining fluids from patients with ARDS...
  34. ncbi Mapping of the genes encoding mouse thromboxane A2 receptor and prostaglandin E receptor subtypes EP2 and EP3
    M Taketo
    Banyu Tsukuba Research Institute Merck, Tsukuba, Japan
    Genomics 19:585-8. 1994
    ..We have mapped genetic loci for TXA2 receptor, Tbxa2r, and for PGE2 receptor subtypes EP2 and EP3, Ptgerep2 and Ptgerep3, respectively, using restriction fragment length variants in interspecific backcross mice...
  35. ncbi Pregnancy and exogenous steroid treatments modulate the expression of relaxant EP(2) and contractile FP receptors in the rat uterus
    Y L Dong
    Department of Obstetrics and Gynecology, The University of Texas Medical Branch, Galveston, Texas 77555, USA
    Biol Reprod 62:533-9. 2000
    ..Therefore, we conclude that steroid hormones modulate the mRNA for relaxant EP(2) and contractile FP receptors for PGs in the uterus and thus regulate uterine activity during pregnancy and labor...
  36. pmc Spinal inflammatory hyperalgesia is mediated by prostaglandin E receptors of the EP2 subtype
    Heiko Reinold
    Institut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Universitat Erlangen Nurnberg, Erlangen, Germany
    J Clin Invest 115:673-9. 2005
    ..Here, we have identified PGE2 receptors of the EP2 receptor subtype as key signaling elements in spinal inflammatory hyperalgesia...
  37. ncbi Coupling of COX-1 to mPGES1 for prostaglandin E2 biosynthesis in the murine mammary gland
    Subhashini Chandrasekharan
    Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Lipid Res 46:2636-48. 2005
    ..Expression of the G(s)-coupled PGE2 receptors, EP2 and EP4, is also temporally regulated, with highest levels detected at stages of maximal proliferation...
  38. ncbi Sequential down-regulation of E-cadherin with squamous cell carcinoma progression: loss of E-cadherin via a prostaglandin E2-EP2 dependent posttranslational mechanism
    Sabine Brouxhon
    Department of Emergency Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Cancer Res 67:7654-64. 2007
    ..indomethacin in vitro, targeted deletion of EP2 in primary mouse keratinocyte (PMK) cultures or deletion of the EP2 receptor in vivo abrogated this UV-induced E-cadherin down-regulation...
  39. pmc The prostaglandin E2 EP2 receptor accelerates disease progression and inflammation in a model of amyotrophic lateral sclerosis
    Xibin Liang
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA
    Ann Neurol 64:304-14. 2008
    ..Recent studies demonstrate that the prostaglandin E(2) EP2 receptor is a major regulator of inflammatory oxidative injury in innate immunity...
  40. pmc Macrophage EP4 deficiency increases apoptosis and suppresses early atherosclerosis
    Vladimir R Babaev
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 6300, USA
    Cell Metab 8:492-501. 2008
    ..The PGE(2) receptors, EP2 and EP4, are expressed in atherosclerotic lesions and are known to inhibit apoptosis in cancer cells...
  41. pmc Protection of hippocampal neurogenesis from toll-like receptor 4-dependent innate immune activation by ablation of prostaglandin E2 receptor subtype EP1 or EP2
    C Dirk Keene
    Department of Pathology, University of Washington, Box 359791, Seattle, WA 98104, USA
    Am J Pathol 174:2300-9. 2009
    ..The prostaglandin E2 receptor family consists of four subtypes of which EP1 and EP2 are known to be expressed by microglia...
  42. pmc Failure of postnatal ductus arteriosus closure in prostaglandin transporter-deficient mice
    Hee Yoon Chang
    Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Circulation 121:529-36. 2010
    ..The rate-limiting step in PGE(2) signal termination is PGE(2) uptake by the transporter PGT...
  43. pmc Decreased RORC-dependent silencing of prostaglandin receptor EP2 induces autoimmune Th17 cells
    David M Kofler
    J Clin Invest 124:2513-22. 2014
    ..immunoprecipitation followed by DNA sequencing revealed that RORγt binds directly to Ptger2 (the gene encoding EP2 receptor) in Th17 cells isolated from WT mice...
  44. pmc Role of the prostaglandin E2/E-prostanoid 2 receptor signalling pathway in TGFβ-induced mice mesangial cell damage
    Na Na Li
    Department of Nephrology, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China
    Biosci Rep 34:e00159. 2014
    The prostaglandin E2 receptor, EP2 (E-prostanoid 2), plays an important role in mice glomerular MCs (mesangial cells) damage induced by TGFβ1 (transforming growth factor-β1); however, the molecular mechanisms for this remain unknown...
  45. pmc EP2 Receptor Signaling Regulates Microglia Death
    Yujiao Fu
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia Y F, M S Y, J J, T G, R D Neurology Department, Xiangya Hospital, Hunan, China Y F and Department of Pharmacology, Ajou University School of Medicine, Suwon, Korea M S Y, E J
    Mol Pharmacol 88:161-70. 2015
    ..We show here that activation of the E prostanoid receptor 2 (EP2, PTGER2) for prostaglandin E2 mediates microglial death induced by LPS/IL-13, and that EP2 activation by agonist alone ..
  46. pmc Prostaglandin E2 and programmed cell death 1 signaling coordinately impair CTL function and survival during chronic viral infection
    Jonathan H Chen
    Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA
    Nat Med 21:327-34. 2015
    ..We found that the prostaglandin E2 (PGE₂) receptors EP2 and EP4 were upregulated on virus-specific CTLs during chronic lymphocytic choriomeningitis virus (LCMV) infection ..
  47. pmc Prostaglandin E2 EP2 receptor deletion attenuates intracerebral hemorrhage-induced brain injury and improves functional recovery
    Jenna L Leclerc
    Department of Anesthesiology, University of Florida, Gainesville, FL, USA Department of Neuroscience, University of Florida, Gainesville, FL, USA
    ASN Neuro 7:. 2015
    ..Signaling through the EP2 receptor has been shown to affect outcomes of many acute and chronic neurological disorders; although, not yet explored ..
  48. pmc A major role for the EP4 receptor in regulation of renin
    Carie S Facemire
    Division of Nephrology, Department of Medicine, Duke University and Durham Veterans Affairs Medical Centers, Durham, USA
    Am J Physiol Renal Physiol 301:F1035-41. 2011
    ..disruption of several key genes: cyclooxygenase-2 (COX-2), microsomal PGE synthases 1 and 2 (mPGES1, mPGES2), EP2 and EP4 receptors for PGE(2), and the IP receptor for PGI(2)...
  49. pmc Prostaglandin E2 restrains macrophage maturation via E prostanoid receptor 2/protein kinase A signaling
    Zbigniew Zaslona
    Divisions of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, USA
    Blood 119:2358-67. 2012
    ..Macrophage maturation was studied in vitro in bone marrow cell cultures, and in vivo in a model of peritonitis. EP2 was the most abundant PGE(2) receptor expressed by bone marrow cells, and its expression further increased during ..
  50. pmc PTGS-2-PTGER2/4 signaling pathway partially protects from diabetogenic toxicity of streptozotocin in mice
    Antje Vennemann
    Department of Clinical Pharmacology, Goethe University Frankfurt, Frankfurt, Germany
    Diabetes 61:1879-87. 2012
    ..STZ metabolism was unaffected by PTGS deficiency. Diabetogenicity of STZ in PTGER1(-/-), PTGER2(-/-), PTGER3(-/-), and PTGER4(-/-) mice was comparable to control mice...
  51. pmc Prostanoid receptor 2 signaling protects T helper 2 cells from BALB/c mice against activation-induced cell death
    Vandana Kaul
    Immunology Group, International Center for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi 110067, India
    J Biol Chem 287:25434-9. 2012
    ..inhibits activation-induced cell death of Th2 cells by signaling through its receptor E-prostanoid receptor 2 (EP2). Consequently, Th2 cells derived from BALB/c mice expressed very high levels of EP2...
  52. ncbi Effects of retinal degeneration and brain size upon spatial reversal learning in mice
    J L Fuller
    Percept Mot Skills 36:947-50. 1973
  53. ncbi Studies on the induction of cyclooxygenase isozymes by various prostaglandins in mouse osteoblastic cell line with reference to signal transduction pathways
    Y Takahashi
    Department of Biochemistry, Tokushima University School of Medicine, Japan
    Biochim Biophys Acta 1212:217-24. 1994
    ....
  54. ncbi The mouse prostaglandin E receptor EP2 subtype: cloning, expression, and northern blot analysis
    M Katsuyama
    Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Kyoto University, Japan
    FEBS Lett 372:151-6. 1995
    ..The mouse EP2 receptor consists of 362 amino acid residues with seven putative transmembrane domains...
  55. ncbi Prostaglandin E2 receptor subtype EP2 gene expression in the mouse uterus coincides with differentiation of the luminal epithelium for implantation
    H Lim
    Department of Molecular and Integrative Physiology, Ralph L Smith Research Center, University of Kansas Medical Center, Kansas City 66160 7336, USA
    Endocrinology 138:4599-606. 1997
    ..Four major PGE2 receptor subtypes, EP1, EP2, EP3, and EP4, mediate various PGE2 effects via their coupling to distinct signaling pathways...
  56. ncbi Embryonic stem cell lines from MRL mice allow genetic modification in a murine model of autoimmune disease
    J L Goulet
    Curriculum in Genetics and Molecular Biology and Department of Medicine, University of North Carolina, Chapel Hill, NC 27599 7248, USA
    J Immunol 159:4376-81. 1997
    ..lines undergo gene targeting by homologous recombination at high frequency by inactivating the gene encoding the EP2 prostaglandin receptor...
  57. pmc Characterization of the gene for the mouse prostaglandin E receptor subtype EP2: tissue-specific initiation of transcription in the macrophage and the uterus
    M Katsuyama
    Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Kyoto University, Kyoto 606, Japan
    Biochem J 330:1115-21. 1998
    Genomic DNA clones for the mouse prostaglandin (PG) E receptor subtype EP2 were isolated and characterized. The mouse EP2 gene is composed of 2 exons and 1 intron, and spans 16 kb. The intron which is approx...
  58. ncbi Impaired bone resorption to prostaglandin E2 in prostaglandin E receptor EP4-knockout mice
    C Miyaura
    Department of Biochemistry, School of Dentistry, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    J Biol Chem 275:19819-23. 2000
    ..and then identified PGE receptor subtype(s) mediating this PGE(2) action using mice lacking each subtype (EP1, EP2, EP3, and EP4) of PGE receptor...
  59. pmc Activation of the murine EP3 receptor for PGE2 inhibits cAMP production and promotes platelet aggregation
    J E Fabre
    Department of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA
    J Clin Invest 107:603-10. 2001
    ..Our results suggest that local production of PGE2 during an inflammatory process can modulate ensuing platelet responses...
  60. ncbi EP2 receptors mediate airway relaxation to substance P, ATP, and PGE2
    C N Fortner
    Department of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0576, USA
    Am J Physiol Lung Cell Mol Physiol 281:L469-74. 2001
    ..Using mice homozygous for a gene-targeted deletion of the EP2 receptor [EP2(-/-)], one of the PGE2 receptors, we tested the hypothesis that PGE2 is the primary mediator of relaxation ..
  61. ncbi Acceleration of intestinal polyposis through prostaglandin receptor EP2 in Apc(Delta 716) knockout mice
    M Sonoshita
    Laboratory of Biomedical Genetics, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan
    Nat Med 7:1048-51. 2001
    ..We also show that COX-2 expression is boosted by PGE(2) through the EP2 receptor via a positive feedback loop...
  62. ncbi Cyclooxygenase 2- and prostaglandin E(2) receptor EP(2)-dependent angiogenesis in Apc(Delta716) mouse intestinal polyps
    Hiroshi Seno
    Department of Pharmacology, Kyoto University Graduate School of Medicine, Kyoto 606 8501, Japan
    Cancer Res 62:506-11. 2002
    ....
  63. ncbi Prostaglandin receptor EP2 mediates PGE2 stimulated hypercalcemia in mice in vivo
    Xiaodong Li
    Department of Medicine, University of Connecticut Health Center, Farmington 06030, USA
    Prostaglandins Other Lipid Mediat 67:173-80. 2002
    ..1 microM) increased cyclic AMP production 3.5-fold, but PGE2 had no effect on cells from mice in which the EP2 receptor had been deleted (EP2 -/-)...
  64. ncbi Decreased expression of tumor necrosis factor-alpha-stimulated gene 6 in cumulus cells of the cyclooxygenase-2 and EP2 null mice
    Scott A Ochsner
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Endocrinology 144:1008-19. 2003
    ..Female mice null for either COX-2 or the PGE(2) receptor EP2 are infertile, show decreased ovulation, and exhibit abnormal cumulus expansion...
  65. ncbi Receptors and pathways mediating the effects of prostaglandin E2 on airway tone
    Stephen L Tilley
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of North Carolina at Chapel Hill, 27599 7248, USA
    Am J Physiol Lung Cell Mol Physiol 284:L599-606. 2003
    ..This segregation of EP receptor function within the airway suggests that PGE(2) analogs that selectively activate the EP2 receptor without activating the EP1/EP3 receptors might prove useful in the treatment of asthma.
  66. ncbi Targeted gene disruption of the prostaglandin E2 EP2 receptor
    Richard M Breyer
    Departments of Medicine Division of Nephrology, Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Adv Exp Med Biol 507:321-6. 2002
  67. ncbi Functional domains essential for Gs activity in prostaglandin EP2 and EP3 receptors
    Yukihiko Sugimoto
    Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606 8501, Sakyo, Japan
    Life Sci 74:135-41. 2003
    ..In EP2 receptor, substitution of IC1 or IC3 resulted in loss of binding activity, while substitution of IC2, N- (IC2N) or C-..
  68. ncbi Stimulation of renin release by prostaglandin E2 is mediated by EP2 and EP4 receptors in mouse kidneys
    Frank Schweda
    Institute for Physiology, University of Regensburg, 93042 Regensburg, Germany
    Am J Physiol Renal Physiol 287:F427-33. 2004
    ..In contrast, all four receptor subtypes are involved in the control of renal vascular tone, EP(1) and EP(3) receptors increasing, and EP(2) as well as EP(4) receptors, decreasing it...
  69. pmc Decreased susceptibility to renovascular hypertension in mice lacking the prostaglandin I2 receptor IP
    Takayuki Fujino
    Department of Pharmacology, Asahikawa Medical College, Japan
    J Clin Invest 114:805-12. 2004
    ..These results indicate that PGI2 derived from COX-2 plays a critical role in regulating the release of renin and consequently renovascular hypertension in vivo...
  70. ncbi Biphasic effect of prostaglandin E2 on osteoclast formation in spleen cell cultures: role of the EP2 receptor
    Katsuhiro Ono
    Department of Medicine, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    J Bone Miner Res 20:23-9. 2005
    ..A selective EP2 receptor agonist mimicked these effects...
  71. ncbi Tumor cyclooxygenase-2/prostaglandin E2-dependent promotion of FOXP3 expression and CD4+ CD25+ T regulatory cell activities in lung cancer
    Sherven Sharma
    Department of Medicine, Lung Cancer Research Program, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095 1960, USA
    Cancer Res 65:5211-20. 2005
    ..gene expression was significantly reduced in the absence of the EP4 receptor and ablated in the absence of the EP2 receptor expression...
  72. ncbi Augmented cardiac hypertrophy in response to pressure overload in mice lacking the prostaglandin I2 receptor
    Akiyoshi Hara
    Department of Pharmacology, Asahikawa Medical College, Midorigaoka Higashi 2 1 1 1, Asahikawa 078 8510, Japan
    Circulation 112:84-92. 2005
    ..However, their roles in cardiac hypertrophy in vivo remain unknown. We intended to clarify the roles of these receptors in pressure overload-induced cardiac hypertrophy using mice lacking each of their receptors...
  73. ncbi Prostaglandin E2 stimulates granulocyte colony-stimulating factor production via the prostanoid EP2 receptor in mouse peritoneal neutrophils
    Yukihiko Sugimoto
    Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan
    J Immunol 175:2606-12. 2005
    ..Indeed, the effect of PGE2 on G-CSF release was abolished in neutrophils isolated from EP2-deficient mice...
  74. ncbi Lack of expression of the EP2 but not EP3 receptor for prostaglandin E2 results in suppression of skin tumor development
    You Me Sung
    The University of Texas M D Anderson Cancer Center, Science Park Research Division, Smithville, TX 78957, USA
    Cancer Res 65:9304-11. 2005
    The EP2 receptor for prostaglandin E2 (PGE2) is a membrane receptor that mediates at least part of the action of PGE2. It has been shown that EP2 plays a critical role in tumorigenesis in mouse mammary gland and colon...
  75. ncbi Targeting PGE2 receptor subtypes rather than cyclooxygenases: a bridge over troubled water?
    Bianca Rocca
    Center of Excellence on Aging, G d Annunzio University Foundation, Chieti, Italy
    Mol Interv 6:68-73, 58. 2006
    ..Has the time come for research to examine earnestly the selective antagonism of EP subtypes rather than further the development of direct COX-2 inhibitors?..
  76. ncbi EP2, a receptor for PGE2, regulates tumor angiogenesis through direct effects on endothelial cell motility and survival
    M Kamiyama
    Department of Radiation Oncology, Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Oncogene 25:7019-28. 2006
    ..We found that deletion of the EP2 receptor impaired tumor angiogenesis and this finding was confirmed by an in vivo corneal angiogenesis model and an ex ..
  77. ncbi The effects of prostaglandin analogues on prostanoid EP1, EP2, and EP3 receptor-deficient mice
    Takashi Ota
    Department of Ophthalmology, University of Tokyo School of Medicine, Japan
    Invest Ophthalmol Vis Sci 47:3395-9. 2006
    ..To determine the role of prostanoid EP receptors in the intraocular pressure (IOP)-lowering effect of prostaglandin analogues in EP receptor-deficient mice...
  78. ncbi Renal prostaglandin E2 receptor (EP) expression profile is altered in streptozotocin and B6-Ins2Akita type I diabetic mice
    Rania Nasrallah
    Department of Cellular and Molecular Medicine, Kidney Research Centre, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada
    Am J Physiol Renal Physiol 292:F278-84. 2007
    ..Therefore, knowing the pattern of change in relative EP receptor expression in the kidney could be useful in identifying specific EP targets for the prevention of various components of diabetic kidney disease...
  79. ncbi Deletion of prostaglandin E2 EP2 receptor protects against ultraviolet-induced carcinogenesis, but increases tumor aggressiveness
    Sabine Brouxhon
    Department of Emergency Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    J Invest Dermatol 127:439-46. 2007
    ..Previous work from our group has shown that the prostaglandin E2 EP2 receptor is a powerful regulator of keratinocyte growth...
  80. pmc Recruitment of a prostaglandin E receptor subtype, EP3-expressing bone marrow cells is crucial in wound-induced angiogenesis
    Emi Kamoshita
    Department of Pharmacology, Kitasato University School of Medicine, Kanagawa 228 8555, Japan
    Am J Pathol 169:1458-72. 2006
    ..knockout mice (EP3-/-) were significantly delayed compared with their wild-type (WT) mice, whereas those in EP1-/-, EP2-/-, and EP4-/- were not delayed...
  81. ncbi Activation of platelet function through G protein-coupled receptors
    Stefan Offermanns
    Institute of Pharmacology, University of Heidelberg, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany
    Circ Res 99:1293-304. 2006
    ..This review summarizes recent progress in understanding the mechanisms underlying platelet activation and thrombus extension via G protein-mediated signaling pathways...
  82. ncbi Activating of ATP-dependent K+ channels comprised of K(ir) 6.2 and SUR 2B by PGE2 through EP2 receptor in cultured interstitial cells of Cajal from murine small intestine
    Seok Choi
    Department of Physiology, College of Medicine, Chosun University, 375 Seosuk dong, Gwangju, South Korea
    Cell Physiol Biochem 18:187-98. 2006
    ..2-SUR 2B in ICC and this action of PGE(2) are through EP(2) receptor subtype and also the activation of ATP-dependent K(+) channels involves intracellular Ca(2+) mobilization...
  83. ncbi Prostaglandin receptor EP2 is responsible for cyclooxygenase-2 induction by prostaglandin E2 in mouse skin
    Kausar M Ansari
    The University of Texas M D Anderson Cancer Center, Science Park Research Division, PO Box 389, Smithville, TX 78957, USA
    Carcinogenesis 28:2063-8. 2007
    ..Taken together, EP2 activation of the PKA/CREB-signaling pathway is responsible for keratinocyte proliferation and our findings reveal a positive feedback loop between COX-2 and PGE2 that is mediated by the EP2 receptor.
  84. ncbi Prostaglandins enhance epidermal growth factor-induced DNA synthesis in hepatocytes by stimulation of E prostanoid 3 and F prostanoid receptors
    Kristin Meisdalen
    Department of Pharmacology, Faculty of Medicine, University of Oslo, P O Box 1057 Blindern, N 0316 Oslo, Norway
    J Pharmacol Exp Ther 322:1044-50. 2007
    ..The EP2 receptor agonist butaprost had no significant effect on EGF-induced DNA synthesis...
  85. pmc Altered hippocampal long-term synaptic plasticity in mice deficient in the PGE2 EP2 receptor
    Hongwei Yang
    Neuroscience Center of Excellence, LSU Health Sciences Center, New Orleans, Louisiana, USA
    J Neurochem 108:295-304. 2009
    ..previously that PGE2-induced modulation of hippocampal synaptic transmission is via a pre-synaptic PGE2 EP2 receptor. However, little is known about whether the EP2 receptor is involved in hippocampal long-term synaptic ..
  86. pmc Efferocytosis impairs pulmonary macrophage and lung antibacterial function via PGE2/EP2 signaling
    Alexandra I Medeiros
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health Systems, Ann Arbor, MI 48109, USA
    J Exp Med 206:61-8. 2009
    ..killing by alveolar macrophages and that this is mediated by a cyclooxygenase-PGE(2)-E prostanoid receptor 2 (EP2)-adenylyl cyclase-cyclic AMP pathway...
  87. pmc Impaired cognition, sensorimotor gating, and hippocampal long-term depression in mice lacking the prostaglandin E2 EP2 receptor
    A Savonenko
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Exp Neurol 217:63-73. 2009
    ..Recent studies demonstrate an emerging role for the downstream PGE(2) EP2 receptor in diverse models of activity-dependent synaptic plasticity and a significant function in models of ..
  88. pmc PGE2 signaling through the EP4 receptor on fibroblasts upregulates RANKL and stimulates osteolysis
    Ryosuke Tsutsumi
    Center for Musculoskeletal Research, University of Rochester, Rochester, New York, USA
    J Bone Miner Res 24:1753-62. 2009
    ..However, the PGE2 receptor (EP1, EP2, or EP4), and cell type in which it is expressed, which is responsible for PGE2 induction of RANKL during wear ..
  89. doi Prostaglandin E2-EP4 signaling promotes immune inflammation through Th1 cell differentiation and Th17 cell expansion
    Chengcan Yao
    Department of Pharmacology, Faculty of Medicine, Kyoto University, Kyoto, Japan
    Nat Med 15:633-40. 2009
    ..Thus, PGE2-EP4 signaling promotes immune inflammation through TH1 differentiation and TH17 expansion, and EP4 antagonism may be therapeutically useful for various immune diseases...
  90. pmc DOCK2 is a microglial specific regulator of central nervous system innate immunity found in normal and Alzheimer's disease brain
    Patrick J Cimino
    Division of Neuropathology, Department of Pathology, the Neurobiology and Behavior Program, University of Washington, Box 359645, Harborview Medical Center, Seattle, WA 98104, USA
    Am J Pathol 175:1622-30. 2009
    ..Previously, the prostaglandin E2 receptor, EP2, was shown to regulate neuroinflammation and reduce Abeta plaque burden in transgenic mice...
  91. doi Expression profiling of cumulus cells reveals functional changes during ovulation and central roles of prostaglandin EP2 receptor in cAMP signaling
    Shigero Tamba
    Department of Physiological Chemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Sakyo ku, Kyoto 606 8501, Japan
    Biochimie 92:665-75. 2010
    To understand the role of prostaglandin (PG) receptor EP2 (Ptger2) signaling in ovulation and fertilization, we investigated time-dependent expression profiles in wild-type (WT) and Ptger2(-/-) cumuli before and after ovulation by using ..
  92. doi CD40 engagement on dendritic cells induces cyclooxygenase-2 and EP2 receptor via p38 and ERK MAPKs
    Hedi Harizi
    CNRS UMR 5540, Bordeaux, Universite Bordeaux 2, Bordeaux, France
    Immunol Cell Biol 89:275-82. 2011
    ..Collectively, we demonstrated that CD40 engagement on mBM-DC upregulates COX-2 and EP2 receptor expression through activation of p38 and ERK1/2 MAPK signaling...
  93. pmc EP1(-/-) mice have enhanced osteoblast differentiation and accelerated fracture repair
    Minjie Zhang
    Center for Musculoskeletal Research, University of Rochester, Rochester, NY, USA
    J Bone Miner Res 26:792-802. 2011
    ..It has four different receptor subtypes (EP1 through EP4), each of which exerts different effects in bone. EP2 and EP4 induce bone formation through the protein kinase A (PKA) pathway, whereas EP3 inhibits bone formation in ..
  94. doi The soluble EP2 receptor FuEP2/Ex2 suppresses endometrial cancer cell growth in an orthotopic xenograft model in nude mice
    Tetsuyuki Takahashi
    Department of Molecular and Environmental Pathology, Institute of Health Biosciences, The University of Tokushima Graduate School, Japan
    Cancer Lett 306:67-75. 2011
    ..Ish-FuEP2/Ex2 cells expressed FuEP2/Ex2 mRNA and protein. Expression levels of E-prostanoid receptor 1 (EP1), EP2, EP3, EP4, and F-prostanoid receptor (FP) were almost the same in Ish-FuEP2/Ex2 and vector control cells...
  95. doi Contribution of peripheral versus central EP1 prostaglandin receptors to inflammatory pain
    Torbjörn Johansson
    Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Neurosci Lett 495:98-101. 2011
    ..Taken together, these results suggest that peripheral EP1 receptors contribute significantly to inflammation induced heat pain sensitization while evidence for a contribution to central sensitization was not obtained...
  96. pmc Prostaglandin E2 release from astrocytes triggers gonadotropin-releasing hormone (GnRH) neuron firing via EP2 receptor activation
    Jérôme Clasadonte
    Institut National de la Sante et de la Recherche Medicale, Jean Pierre Aubert Research Center, U837, Development and Plasticity of the Postnatal Brain, F 59000 Lille, France
    Proc Natl Acad Sci U S A 108:16104-9. 2011
    ..These effects are mimicked by an EP2 receptor agonist and attenuated by protein kinase A (PKA) inhibitors...
  97. ncbi Cloning of a novel human prostaglandin receptor with characteristics of the pharmacologically defined EP2 subtype
    J W Regan
    Department of Pharmacology and Toxicology, University of Arizona, Tucson 85721
    Mol Pharmacol 46:213-20. 1994
    ..Our findings suggest that Hup-4 encodes the pharmacologically defined EP2 receptor, whereas the mouse and human cDNAs previously classified as EP2 may represent another EP receptor subtype or ..
  98. ncbi 'Distinct cellular localization' of the messenger ribonucleic acid for prostaglandin E receptor subtypes in the mouse uterus during pseudopregnancy
    M Katsuyama
    Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Kyoto University, Japan
    Endocrinology 138:344-50. 1997
    ..uterine actions of PGE2, expression patterns of the messenger RNAs (mRNAs) for four subtypes of PGE receptors, EP1, EP2, EP3, and EP4, were investigated in the mouse uterus during pseudopregnancy...
  99. ncbi Role of EP(2) and EP(3) PGE(2) receptors in control of murine renal hemodynamics
    L P Audoly
    Department of Medicine, Duke University and Durham Veterans Affairs Medical Center, Durham, North Carolina 27710, USA
    Am J Physiol Heart Circ Physiol 280:H327-33. 2001
    ..We conclude that EP(3 )receptors mediate vasoconstriction in the kidney of male mice and its actions are tonically active in the basal state. Furthermore, EP(3) receptors are capable of buffering PGE(2)-mediated renal vasodilation...
  100. ncbi Diversification of cyclooxygenase-2-derived prostaglandins in ovulation and implantation
    H Matsumoto
    Department of Molecular and Integrative Physiology, Ralph L Smith Research Center, University of Kansas Medical Center, Kansas City, Kansas 66160 7338, USA
    Biol Reprod 64:1557-65. 2001
    ....

Research Grants7

  1. CXC CHEMOKINE REGULATION OF PROSTATE CANCER ANGIOGENESIS
    Bethany Moore; Fiscal Year: 2002
    ..These studies should lead to new insights into the biology of prostate cancer growth and metastasis, and pave the way to adapt adjuvant therapies for the treatment of this widespread disease. ..
  2. LIPID PEROXIDATION AND APOE IN ALZHEIMERS DISEASE
    Thomas Montine; Fiscal Year: 2003
    ..This new information will aid in laying the foundation for designing rational therapeutic approaches to ameliorate brain oxidative damage in Alzheimer's disease. ..
  3. CATECHOL THIOETHERS IN PARKINSON'S DISEASE
    Thomas Montine; Fiscal Year: 2004
    ....
  4. PGE2 Regulation of Epithelial/Fibroblast Interactions
    Bethany Moore; Fiscal Year: 2006
    ..Fibrotic alterations to EP2 and/or EP4 receptor expression and/or signaling could abrogate suppressive PGE 2 actions on fibroblasts...
  5. Characterization of Dementia with Lewy Bodies: A Collaborative Study
    Thomas Montine; Fiscal Year: 2007
    ..This resource will be made available for future investigations of DLB. ..
  6. Lipid Oxidation Products in Alzheimer's Disease
    Thomas Montine; Fiscal Year: 2007
    ..abstract_text> ..
  7. Proteomic Discovery in Parkinson-Dementia Complex of Guam
    Thomas Montine; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..