Genomes and Genes
Gene Symbol: Ptger2
Description: prostaglandin E receptor 2 (subtype EP2)
Alias: EP2, Ptgerep2, prostaglandin E2 receptor EP2 subtype, EP2 receptor, PGE receptor EP2 subtype, PGE2 receptor EP2 subtype, prostaglandin E receptor 2 (EP2 subtype), prostaglandin E receptor EP2 subtype, prostaglandin E receptor subtype EP2, prostanoid EP2 receptor
Publications118 found, 100 shown here
- Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signalingKatia Boniface
Department of Immunology, Schering Plough Biopharma, Palo Alto, CA 94304, USA
J Exp Med 206:535-48. 2009..In human purified naive T cells, PGE2 acts via prostaglandin receptor EP2- and EP4-mediated signaling and cyclic AMP pathways to up-regulate IL-23 and IL-1 receptor expression...
- Insight into prostaglandin, leukotriene, and other eicosanoid functions using mice with targeted gene disruptionsS C Austin
Center for Experimental Therapeutics, Stellar Chance Labs, University of Pennsylvania, Philadelphia 19104, USA
Prostaglandins Other Lipid Mediat 58:231-52. 1999..g., receptors for various prostaglandins). This minireview will outline the phenotype of these knockout mice and what has been learned about eicosanoid functions through use of this novel methodology...
- Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3F Ushikubi
Department of Pharmacology, Faculty of Medicine, Kyoto University, Japan
Nature 395:281-4. 1998..PGE2 acts by interacting with four subtypes of PGE receptor, the EP1, EP2, EP3 and EP4 receptors. Here we generate mice lacking each of these receptors by homologous recombination...
- Salt-sensitive hypertension and reduced fertility in mice lacking the prostaglandin EP2 receptorC R Kennedy
Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2372, USA
Nat Med 5:217-20. 1999..To evaluate the physiologic role of the PGE2 EP2 receptor subtype, we created mice with targeted disruption of this gene (EP2-/-)...
- Reproductive failure and reduced blood pressure in mice lacking the EP2 prostaglandin E2 receptorS L Tilley
Department of Medicine, University of North Carolina Chapel Hill, Chapel Hill, North Carolina 27599 7248, USA
J Clin Invest 103:1539-45. 1999..Using mice deficient in 1 of 4 prostaglandin E2 (PGE2) receptors -- specifically, the EP2 receptor -- we show that Ep2(-/-) females are infertile secondary to failure of the released ovum to become fertilized ..
- Abortive expansion of the cumulus and impaired fertility in mice lacking the prostaglandin E receptor subtype EP(2)H Hizaki
Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Faculty of Medicine, Kyoto University, Kyoto 606 8501, Japan
Proc Natl Acad Sci U S A 96:10501-6. 1999..These results indicate that PGE(2) cooperates with gonadotropin to complete cumulus expansion for successful fertilization...
- Prostanoid receptors: structures, properties, and functionsS Narumiya
Department of Pharmacology, Kyoto University Faculty of Medicine, Kyoto, Japan
Physiol Rev 79:1193-226. 1999..In this article, we summarize these findings and attempt to give an overview of the current status of research on the prostanoid receptors...
- Knockout of the murine prostaglandin EP2 receptor impairs osteoclastogenesis in vitroX Li
Department of Medicine, University of Connecticut Health Center, Farmington 06030, USA
Endocrinology 141:2054-61. 2000..We used cells from mice in which the EP2 receptor had been disrupted to test its role in the formation of TRAP + MNC...
- Bone biomechanical properties in prostaglandin EP1 and EP2 knockout miceM P Akhter
Osteoporosis Research Center, Creighton University, Omaha, NE 68131, USA
Bone 29:121-5. 2001..The PGE2 influence on bone is mediated through four well-characterized receptors (EP1, EP2, EP3, and EP4)...
- The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gutKenji Kabashima
Department of Pharmacology, Faculty of Medicine, Kyoto University, Kyoto, Japan
J Clin Invest 109:883-93. 2002..Among the prostanoid receptor-deficient mice, only EP4-deficient mice and not mice deficient in either DP, EP1, EP2, EP3, FP, IP, or TP developed severe colitis with 3% DSS treatment, which induced only marginal colitis in wild-..
- The role of prostaglandin E2 receptors in the pathogenesis of rheumatoid arthritisJennifer M McCoy
Pfizer Global Research and Development, Department of Inflammation and Pathology, Groton, Connecticut 06340, USA
J Clin Invest 110:651-8. 2002..Homozygous deletion of the EP1, EP2, or EP3 receptors did not affect the development of arthritis, whereas EP4 receptor-deficient mice showed decreased ..
- Impaired adrenocorticotropic hormone response to bacterial endotoxin in mice deficient in prostaglandin E receptor EP1 and EP3 subtypesYoko Matsuoka
Department of Pharmacology, Kyoto University Faculty of Medicine, Kyoto 606 8501, Japan
Proc Natl Acad Sci U S A 100:4132-7. 2003..These findings suggest that EP1- and EP3-mediated neuronal pathways converge at corticotropin-releasing hormone-containing neurons in the PVN to induce HPA axis activation upon sickness...
- Prostaglandin E2-EP4 signaling initiates skin immune responses by promoting migration and maturation of Langerhans cellsKenji Kabashima
Department of Pharmacology, Kyoto University Faculty of Medicine, Kyoto 606 8501, Japan
Nat Med 9:744-9. 2003..PGE2-EP4 signaling thus facilitates initiation of skin immune responses by promoting the migration and maturation of Langerhans cells...
- Suppression of allergic inflammation by the prostaglandin E receptor subtype EP3Tomonori Kunikata
Department of Pharmacology and Faculty of Medicine and Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606 8501, Japan
Nat Immunol 6:524-31. 2005..Thus, the PGE(2)-EP3 pathway is an important negative modulator of allergic reactions...
- Prostaglandin E2 receptors EP2 and EP4 are down-regulated during differentiation of mouse osteoclasts from their precursorsYasuhiro Kobayashi
Institute for Oral Science, Matsumoto Dental University, 1780 Hiro oka Gobara, Shiojiri, Nagano 399 0781, Japan
J Biol Chem 280:24035-42. 2005..Bone marrow macrophage osteoclast precursors expressed PGE2 receptors EP1, EP2, EP3beta, and EP4, and the expression of EP2 and EP4 was down-regulated during osteoclastic differentiation induced ..
- Age-induced reprogramming of mast cell degranulationMyTrang Nguyen
Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA
J Immunol 175:5701-7. 2005..Therefore, elevated PGE2 levels might provide an important pathway by which mast cells are engaged to participate in inflammatory responses in the elderly patient...
- Prostaglandin E2 is required for ultraviolet B-induced skin inflammation via EP2 and EP4 receptorsKenji Kabashima
Department of Pharmacology, Kyoto University Graduate School of Medicine, Sakyo, Kyoto, Japan
Lab Invest 87:49-55. 2007..The UV-induced ear swelling at 48 h after exposure was significantly reduced in EP2(-/-), EP4(-/-) or wild-type mice treated with the EP4 antagonist compared to control mice...
- Synthetic prostacyclin analogs differentially regulate macrophage function via distinct analog-receptor binding specificitiesDavid M Aronoff
Division of Infectious Diseases, Department of Internal Medicine, University of Michigan Health Systems, Ann Arbor, MI 48109, USA
J Immunol 178:1628-34. 2007..indicated that this was due in part to the previously unknown ability of treprostinil to stimulate the EP2 receptor. The present investigation for the first time identifies differences in immunoregulatory properties of ..
- Prostaglandin E receptorsYukihiko Sugimoto
Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, Faculty of Medicine, Kyoto University, Kyoto 606 8501, Japan
J Biol Chem 282:11613-7. 2007..There are four GPCRs responding to PGE(2) designated subtypes EP1, EP2, EP3, and EP4 and multiple splicing isoforms of the subtype EP3...
- Bacterial clearance of Pseudomonas aeruginosa is enhanced by the inhibition of COX-2Ruxana T Sadikot
Department of Veterans Affairs, Jesse Brown VA Hospital, Chicago, IL 60612, USA
Eur J Immunol 37:1001-9. 2007..Furthermore there was enhanced bacterial clearance in EP2 receptor(-/-) mice compared to the wild-type controls...
- Prostaglandin E2 suppresses bacterial killing in alveolar macrophages by inhibiting NADPH oxidaseCarlos H Serezani
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health Systems, Ann Arbor, Michigan 48109 0642, USA
Am J Respir Cell Mol Biol 37:562-70. 2007..was blocked by an adenylyl cyclase inhibitor and mimicked by agonists for the stimulatory G protein (G(s))-coupled EP2 and EP4 receptors...
- Increased dietary NaCl induces renal medullary PGE2 production and natriuresis via the EP2 receptorJian Chen
Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
Am J Physiol Renal Physiol 295:F818-25. 2008..Renal medullary PGE(2) promotes renal sodium excretion via the EP2 receptor, thereby maintaining normotension in the setting of high salt intake.
- Bone marrow stromal cells attenuate sepsis via prostaglandin E(2)-dependent reprogramming of host macrophages to increase their interleukin-10 productionKrisztian Nemeth
National Institute of Dental and Craniofacial Research NIDCR, Craniofacial and Skeletal Diseases Branch, NIH, Bethesda, MD 20892, USA
Nat Med 15:42-9. 2009..reprogram macrophages by releasing prostaglandin E(2) that acts on the macrophages through the prostaglandin EP2 and EP4 receptors...
- Prostaglandin E(2) induces fibroblast apoptosis by modulating multiple survival pathwaysSteven K Huang
Pulmonary and Critical Care Medicine, University of Michigan, 6301 MSRB III, 1150 W Medical Center Dr, Ann Arbor, MI 48109 5642, USA
FASEB J 23:4317-26. 2009..These proapoptotic actions were dependent on signaling through the EP2/EP4 receptors and by downstream activation of both caspases 8 and 9...
- Temporal expression of the PGE2 synthetic system in the kidney is associated with the time frame of renal developmental vulnerability to cyclooxygenase-2 inhibitionStefanie Frölich
Institute of Clinical Pharmacology, Johann Wolfgang Goethe University, Theodor Stern Kai 7, Frankfurt, Germany
Am J Physiol Renal Physiol 303:F209-19. 2012..Studying glomerulogenesis in EP receptor knockout mice revealed a reduction in glomerular size in EP1(-/-), EP2(-/-), and EP4(-/-) mice, supporting the developmental role of PGE(2)...
- Differential stem- and progenitor-cell trafficking by prostaglandin E2Jonathan Hoggatt
Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
Nature 495:365-9. 2013..These results not only uncover unique regulatory roles for EP4 signalling in HSC retention in the niche, but also define a rapidly translatable strategy to enhance transplantation therapeutically...
- PGE2-mediated upregulation of iNOS in murine breast cancer cells through the activation of EP4 receptorsAlexander V Timoshenko
Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario, Canada
Int J Cancer 108:384-9. 2004....
- Prostaglandin E and prostacyclin receptor expression in tumor and host tissues from MCG 101-bearing mice: a model with prostanoid-related cachexiaWenhua Wang
Surgical Metabolic Research Laboratory at Lundberg Laboratory for Cancer Research, Department of Surgery, Sahlgrenska University Hospital, Goteborg, Sweden
Int J Cancer 115:582-90. 2005..Expressions of PGE (EP1, EP2, EP3alpha,beta,gamma and EP4) and PGI (IP) receptors in the central nervous system (brain cortex, hypothalamus and ..
- Prostaglandin E2 protects lower airways against bronchoconstrictionJohn M Hartney
Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, NC 27599, USA
Am J Physiol Lung Cell Mol Physiol 290:L105-13. 2006..mice lacking this synthase (Ptges-/-) and receptors that mediate the actions of PGE2, particularly the PGE2 EP2 receptor (Ptger2)...
- Increased prostaglandin E₂-EP2 signalling in cumulus cells of female mice sired by males with the Y-chromosome long-arm deletionKatarzyna Kotarska
Department of Genetics and Evolution, Institute of Zoology, Jagiellonian University, Gronostajowa 9, 30 387 Krakow, Poland
Reprod Fertil Dev 25:900-6. 2013..BR(Y(del)) females display higher surface accumulation of prostaglandin EP2 subtype receptors and higher expression of the Ptgs2 gene (encoding a rate-limiting enzyme of prostaglandin E₂ ..
- Fluid flow shear stress upregulates prostanoid receptor EP2 but not EP4 in murine podocytesTarak Srivastava
Section of Nephrology, Children s Mercy Hospital and University of Missouri at Kansas City, Kansas City, MO 64108, USA
Prostaglandins Other Lipid Mediat 104:49-57. 2013..of RT-PCR, qRT-PCR, immunoblotting and immunofluorescence studies indicate that cultured podocytes express EP1, EP2 and EP4 but not EP3. FFSS resulted in upregulated expression of only EP2 in podocytes...
- Prostaglandin E2 blockade enhances the pulmonary anti-Cryptococcus neoformans immune reaction via the induction of TLR-4Liyun Shen
Department of Hematology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou 450014, China Electronic address
Int Immunopharmacol 28:376-81. 2015..forming unit (CFU) assays demonstrated that the cryptococcal infection was dramatically depressed in mice given EP2 and EP4 or single EP antagonist treatment compared to the untreated wild type mice (p<0...
- Local abnormalities in coagulation and fibrinolytic pathways predispose to alveolar fibrin deposition in the adult respiratory distress syndromeS Idell
Department of Medicine, University of Texas Health Center, Tyler 75710
J Clin Invest 84:695-705. 1989..We conclude that abnormalities that result in enhanced coagulation and depressed fibrinolysis, thereby predisposing to alveolar fibrin deposition, occur in the alveolar lining fluids from patients with ARDS...
- Mapping of the genes encoding mouse thromboxane A2 receptor and prostaglandin E receptor subtypes EP2 and EP3M Taketo
Banyu Tsukuba Research Institute Merck, Tsukuba, Japan
Genomics 19:585-8. 1994..We have mapped genetic loci for TXA2 receptor, Tbxa2r, and for PGE2 receptor subtypes EP2 and EP3, Ptgerep2 and Ptgerep3, respectively, using restriction fragment length variants in interspecific backcross mice...
- Pregnancy and exogenous steroid treatments modulate the expression of relaxant EP(2) and contractile FP receptors in the rat uterusY L Dong
Department of Obstetrics and Gynecology, The University of Texas Medical Branch, Galveston, Texas 77555, USA
Biol Reprod 62:533-9. 2000..Therefore, we conclude that steroid hormones modulate the mRNA for relaxant EP(2) and contractile FP receptors for PGs in the uterus and thus regulate uterine activity during pregnancy and labor...
- Spinal inflammatory hyperalgesia is mediated by prostaglandin E receptors of the EP2 subtypeHeiko Reinold
Institut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Universitat Erlangen Nurnberg, Erlangen, Germany
J Clin Invest 115:673-9. 2005..Here, we have identified PGE2 receptors of the EP2 receptor subtype as key signaling elements in spinal inflammatory hyperalgesia...
- Coupling of COX-1 to mPGES1 for prostaglandin E2 biosynthesis in the murine mammary glandSubhashini Chandrasekharan
Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
J Lipid Res 46:2636-48. 2005..Expression of the G(s)-coupled PGE2 receptors, EP2 and EP4, is also temporally regulated, with highest levels detected at stages of maximal proliferation...
- Sequential down-regulation of E-cadherin with squamous cell carcinoma progression: loss of E-cadherin via a prostaglandin E2-EP2 dependent posttranslational mechanismSabine Brouxhon
Department of Emergency Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
Cancer Res 67:7654-64. 2007..indomethacin in vitro, targeted deletion of EP2 in primary mouse keratinocyte (PMK) cultures or deletion of the EP2 receptor in vivo abrogated this UV-induced E-cadherin down-regulation...
- The prostaglandin E2 EP2 receptor accelerates disease progression and inflammation in a model of amyotrophic lateral sclerosisXibin Liang
Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA
Ann Neurol 64:304-14. 2008..Recent studies demonstrate that the prostaglandin E(2) EP2 receptor is a major regulator of inflammatory oxidative injury in innate immunity...
- Macrophage EP4 deficiency increases apoptosis and suppresses early atherosclerosisVladimir R Babaev
Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 6300, USA
Cell Metab 8:492-501. 2008..The PGE(2) receptors, EP2 and EP4, are expressed in atherosclerotic lesions and are known to inhibit apoptosis in cancer cells...
- Protection of hippocampal neurogenesis from toll-like receptor 4-dependent innate immune activation by ablation of prostaglandin E2 receptor subtype EP1 or EP2C Dirk Keene
Department of Pathology, University of Washington, Box 359791, Seattle, WA 98104, USA
Am J Pathol 174:2300-9. 2009..The prostaglandin E2 receptor family consists of four subtypes of which EP1 and EP2 are known to be expressed by microglia...
- Failure of postnatal ductus arteriosus closure in prostaglandin transporter-deficient miceHee Yoon Chang
Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Circulation 121:529-36. 2010..The rate-limiting step in PGE(2) signal termination is PGE(2) uptake by the transporter PGT...
- Decreased RORC-dependent silencing of prostaglandin receptor EP2 induces autoimmune Th17 cellsDavid M Kofler
J Clin Invest 124:2513-22. 2014..immunoprecipitation followed by DNA sequencing revealed that RORγt binds directly to Ptger2 (the gene encoding EP2 receptor) in Th17 cells isolated from WT mice...
- Role of the prostaglandin E2/E-prostanoid 2 receptor signalling pathway in TGFβ-induced mice mesangial cell damageNa Na Li
Department of Nephrology, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China
Biosci Rep 34:e00159. 2014The prostaglandin E2 receptor, EP2 (E-prostanoid 2), plays an important role in mice glomerular MCs (mesangial cells) damage induced by TGFβ1 (transforming growth factor-β1); however, the molecular mechanisms for this remain unknown...
- EP2 Receptor Signaling Regulates Microglia DeathYujiao Fu
Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia Y F, M S Y, J J, T G, R D Neurology Department, Xiangya Hospital, Hunan, China Y F and Department of Pharmacology, Ajou University School of Medicine, Suwon, Korea M S Y, E J
Mol Pharmacol 88:161-70. 2015..We show here that activation of the E prostanoid receptor 2 (EP2, PTGER2) for prostaglandin E2 mediates microglial death induced by LPS/IL-13, and that EP2 activation by agonist alone ..
- Prostaglandin E2 and programmed cell death 1 signaling coordinately impair CTL function and survival during chronic viral infectionJonathan H Chen
Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA
Nat Med 21:327-34. 2015..We found that the prostaglandin E2 (PGE₂) receptors EP2 and EP4 were upregulated on virus-specific CTLs during chronic lymphocytic choriomeningitis virus (LCMV) infection ..
- Prostaglandin E2 EP2 receptor deletion attenuates intracerebral hemorrhage-induced brain injury and improves functional recoveryJenna L Leclerc
Department of Anesthesiology, University of Florida, Gainesville, FL, USA Department of Neuroscience, University of Florida, Gainesville, FL, USA
ASN Neuro 7:. 2015..Signaling through the EP2 receptor has been shown to affect outcomes of many acute and chronic neurological disorders; although, not yet explored ..
- A major role for the EP4 receptor in regulation of reninCarie S Facemire
Division of Nephrology, Department of Medicine, Duke University and Durham Veterans Affairs Medical Centers, Durham, USA
Am J Physiol Renal Physiol 301:F1035-41. 2011..disruption of several key genes: cyclooxygenase-2 (COX-2), microsomal PGE synthases 1 and 2 (mPGES1, mPGES2), EP2 and EP4 receptors for PGE(2), and the IP receptor for PGI(2)...
- Prostaglandin E2 restrains macrophage maturation via E prostanoid receptor 2/protein kinase A signalingZbigniew Zaslona
Divisions of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, USA
Blood 119:2358-67. 2012..Macrophage maturation was studied in vitro in bone marrow cell cultures, and in vivo in a model of peritonitis. EP2 was the most abundant PGE(2) receptor expressed by bone marrow cells, and its expression further increased during ..
- PTGS-2-PTGER2/4 signaling pathway partially protects from diabetogenic toxicity of streptozotocin in miceAntje Vennemann
Department of Clinical Pharmacology, Goethe University Frankfurt, Frankfurt, Germany
Diabetes 61:1879-87. 2012..STZ metabolism was unaffected by PTGS deficiency. Diabetogenicity of STZ in PTGER1(-/-), PTGER2(-/-), PTGER3(-/-), and PTGER4(-/-) mice was comparable to control mice...
- Prostanoid receptor 2 signaling protects T helper 2 cells from BALB/c mice against activation-induced cell deathVandana Kaul
Immunology Group, International Center for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi 110067, India
J Biol Chem 287:25434-9. 2012..inhibits activation-induced cell death of Th2 cells by signaling through its receptor E-prostanoid receptor 2 (EP2). Consequently, Th2 cells derived from BALB/c mice expressed very high levels of EP2...
- Effects of retinal degeneration and brain size upon spatial reversal learning in miceJ L Fuller
Percept Mot Skills 36:947-50. 1973
- Studies on the induction of cyclooxygenase isozymes by various prostaglandins in mouse osteoblastic cell line with reference to signal transduction pathwaysY Takahashi
Department of Biochemistry, Tokushima University School of Medicine, Japan
Biochim Biophys Acta 1212:217-24. 1994....
- The mouse prostaglandin E receptor EP2 subtype: cloning, expression, and northern blot analysisM Katsuyama
Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Kyoto University, Japan
FEBS Lett 372:151-6. 1995..The mouse EP2 receptor consists of 362 amino acid residues with seven putative transmembrane domains...
- Prostaglandin E2 receptor subtype EP2 gene expression in the mouse uterus coincides with differentiation of the luminal epithelium for implantationH Lim
Department of Molecular and Integrative Physiology, Ralph L Smith Research Center, University of Kansas Medical Center, Kansas City 66160 7336, USA
Endocrinology 138:4599-606. 1997..Four major PGE2 receptor subtypes, EP1, EP2, EP3, and EP4, mediate various PGE2 effects via their coupling to distinct signaling pathways...
- Embryonic stem cell lines from MRL mice allow genetic modification in a murine model of autoimmune diseaseJ L Goulet
Curriculum in Genetics and Molecular Biology and Department of Medicine, University of North Carolina, Chapel Hill, NC 27599 7248, USA
J Immunol 159:4376-81. 1997..lines undergo gene targeting by homologous recombination at high frequency by inactivating the gene encoding the EP2 prostaglandin receptor...
- Characterization of the gene for the mouse prostaglandin E receptor subtype EP2: tissue-specific initiation of transcription in the macrophage and the uterusM Katsuyama
Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Kyoto University, Kyoto 606, Japan
Biochem J 330:1115-21. 1998Genomic DNA clones for the mouse prostaglandin (PG) E receptor subtype EP2 were isolated and characterized. The mouse EP2 gene is composed of 2 exons and 1 intron, and spans 16 kb. The intron which is approx...
- Impaired bone resorption to prostaglandin E2 in prostaglandin E receptor EP4-knockout miceC Miyaura
Department of Biochemistry, School of Dentistry, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
J Biol Chem 275:19819-23. 2000..and then identified PGE receptor subtype(s) mediating this PGE(2) action using mice lacking each subtype (EP1, EP2, EP3, and EP4) of PGE receptor...
- Activation of the murine EP3 receptor for PGE2 inhibits cAMP production and promotes platelet aggregationJ E Fabre
Department of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA
J Clin Invest 107:603-10. 2001..Our results suggest that local production of PGE2 during an inflammatory process can modulate ensuing platelet responses...
- EP2 receptors mediate airway relaxation to substance P, ATP, and PGE2C N Fortner
Department of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0576, USA
Am J Physiol Lung Cell Mol Physiol 281:L469-74. 2001..Using mice homozygous for a gene-targeted deletion of the EP2 receptor [EP2(-/-)], one of the PGE2 receptors, we tested the hypothesis that PGE2 is the primary mediator of relaxation ..
- Acceleration of intestinal polyposis through prostaglandin receptor EP2 in Apc(Delta 716) knockout miceM Sonoshita
Laboratory of Biomedical Genetics, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan
Nat Med 7:1048-51. 2001..We also show that COX-2 expression is boosted by PGE(2) through the EP2 receptor via a positive feedback loop...
- Cyclooxygenase 2- and prostaglandin E(2) receptor EP(2)-dependent angiogenesis in Apc(Delta716) mouse intestinal polypsHiroshi Seno
Department of Pharmacology, Kyoto University Graduate School of Medicine, Kyoto 606 8501, Japan
Cancer Res 62:506-11. 2002....
- Prostaglandin receptor EP2 mediates PGE2 stimulated hypercalcemia in mice in vivoXiaodong Li
Department of Medicine, University of Connecticut Health Center, Farmington 06030, USA
Prostaglandins Other Lipid Mediat 67:173-80. 2002..1 microM) increased cyclic AMP production 3.5-fold, but PGE2 had no effect on cells from mice in which the EP2 receptor had been deleted (EP2 -/-)...
- Decreased expression of tumor necrosis factor-alpha-stimulated gene 6 in cumulus cells of the cyclooxygenase-2 and EP2 null miceScott A Ochsner
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
Endocrinology 144:1008-19. 2003..Female mice null for either COX-2 or the PGE(2) receptor EP2 are infertile, show decreased ovulation, and exhibit abnormal cumulus expansion...
- Receptors and pathways mediating the effects of prostaglandin E2 on airway toneStephen L Tilley
Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of North Carolina at Chapel Hill, 27599 7248, USA
Am J Physiol Lung Cell Mol Physiol 284:L599-606. 2003..This segregation of EP receptor function within the airway suggests that PGE(2) analogs that selectively activate the EP2 receptor without activating the EP1/EP3 receptors might prove useful in the treatment of asthma.
- Targeted gene disruption of the prostaglandin E2 EP2 receptorRichard M Breyer
Departments of Medicine Division of Nephrology, Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
Adv Exp Med Biol 507:321-6. 2002
- Functional domains essential for Gs activity in prostaglandin EP2 and EP3 receptorsYukihiko Sugimoto
Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606 8501, Sakyo, Japan
Life Sci 74:135-41. 2003..In EP2 receptor, substitution of IC1 or IC3 resulted in loss of binding activity, while substitution of IC2, N- (IC2N) or C-..
- Stimulation of renin release by prostaglandin E2 is mediated by EP2 and EP4 receptors in mouse kidneysFrank Schweda
Institute for Physiology, University of Regensburg, 93042 Regensburg, Germany
Am J Physiol Renal Physiol 287:F427-33. 2004..In contrast, all four receptor subtypes are involved in the control of renal vascular tone, EP(1) and EP(3) receptors increasing, and EP(2) as well as EP(4) receptors, decreasing it...
- Decreased susceptibility to renovascular hypertension in mice lacking the prostaglandin I2 receptor IPTakayuki Fujino
Department of Pharmacology, Asahikawa Medical College, Japan
J Clin Invest 114:805-12. 2004..These results indicate that PGI2 derived from COX-2 plays a critical role in regulating the release of renin and consequently renovascular hypertension in vivo...
- Biphasic effect of prostaglandin E2 on osteoclast formation in spleen cell cultures: role of the EP2 receptorKatsuhiro Ono
Department of Medicine, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
J Bone Miner Res 20:23-9. 2005..A selective EP2 receptor agonist mimicked these effects...
- Tumor cyclooxygenase-2/prostaglandin E2-dependent promotion of FOXP3 expression and CD4+ CD25+ T regulatory cell activities in lung cancerSherven Sharma
Department of Medicine, Lung Cancer Research Program, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095 1960, USA
Cancer Res 65:5211-20. 2005..gene expression was significantly reduced in the absence of the EP4 receptor and ablated in the absence of the EP2 receptor expression...
- Augmented cardiac hypertrophy in response to pressure overload in mice lacking the prostaglandin I2 receptorAkiyoshi Hara
Department of Pharmacology, Asahikawa Medical College, Midorigaoka Higashi 2 1 1 1, Asahikawa 078 8510, Japan
Circulation 112:84-92. 2005..However, their roles in cardiac hypertrophy in vivo remain unknown. We intended to clarify the roles of these receptors in pressure overload-induced cardiac hypertrophy using mice lacking each of their receptors...
- Prostaglandin E2 stimulates granulocyte colony-stimulating factor production via the prostanoid EP2 receptor in mouse peritoneal neutrophilsYukihiko Sugimoto
Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan
J Immunol 175:2606-12. 2005..Indeed, the effect of PGE2 on G-CSF release was abolished in neutrophils isolated from EP2-deficient mice...
- Lack of expression of the EP2 but not EP3 receptor for prostaglandin E2 results in suppression of skin tumor developmentYou Me Sung
The University of Texas M D Anderson Cancer Center, Science Park Research Division, Smithville, TX 78957, USA
Cancer Res 65:9304-11. 2005The EP2 receptor for prostaglandin E2 (PGE2) is a membrane receptor that mediates at least part of the action of PGE2. It has been shown that EP2 plays a critical role in tumorigenesis in mouse mammary gland and colon...
- Targeting PGE2 receptor subtypes rather than cyclooxygenases: a bridge over troubled water?Bianca Rocca
Center of Excellence on Aging, G d Annunzio University Foundation, Chieti, Italy
Mol Interv 6:68-73, 58. 2006..Has the time come for research to examine earnestly the selective antagonism of EP subtypes rather than further the development of direct COX-2 inhibitors?..
- EP2, a receptor for PGE2, regulates tumor angiogenesis through direct effects on endothelial cell motility and survivalM Kamiyama
Department of Radiation Oncology, Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA
Oncogene 25:7019-28. 2006..We found that deletion of the EP2 receptor impaired tumor angiogenesis and this finding was confirmed by an in vivo corneal angiogenesis model and an ex ..
- The effects of prostaglandin analogues on prostanoid EP1, EP2, and EP3 receptor-deficient miceTakashi Ota
Department of Ophthalmology, University of Tokyo School of Medicine, Japan
Invest Ophthalmol Vis Sci 47:3395-9. 2006..To determine the role of prostanoid EP receptors in the intraocular pressure (IOP)-lowering effect of prostaglandin analogues in EP receptor-deficient mice...
- Renal prostaglandin E2 receptor (EP) expression profile is altered in streptozotocin and B6-Ins2Akita type I diabetic miceRania Nasrallah
Department of Cellular and Molecular Medicine, Kidney Research Centre, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada
Am J Physiol Renal Physiol 292:F278-84. 2007..Therefore, knowing the pattern of change in relative EP receptor expression in the kidney could be useful in identifying specific EP targets for the prevention of various components of diabetic kidney disease...
- Deletion of prostaglandin E2 EP2 receptor protects against ultraviolet-induced carcinogenesis, but increases tumor aggressivenessSabine Brouxhon
Department of Emergency Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
J Invest Dermatol 127:439-46. 2007..Previous work from our group has shown that the prostaglandin E2 EP2 receptor is a powerful regulator of keratinocyte growth...
- Recruitment of a prostaglandin E receptor subtype, EP3-expressing bone marrow cells is crucial in wound-induced angiogenesisEmi Kamoshita
Department of Pharmacology, Kitasato University School of Medicine, Kanagawa 228 8555, Japan
Am J Pathol 169:1458-72. 2006..knockout mice (EP3-/-) were significantly delayed compared with their wild-type (WT) mice, whereas those in EP1-/-, EP2-/-, and EP4-/- were not delayed...
- Activation of platelet function through G protein-coupled receptorsStefan Offermanns
Institute of Pharmacology, University of Heidelberg, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany
Circ Res 99:1293-304. 2006..This review summarizes recent progress in understanding the mechanisms underlying platelet activation and thrombus extension via G protein-mediated signaling pathways...
- Activating of ATP-dependent K+ channels comprised of K(ir) 6.2 and SUR 2B by PGE2 through EP2 receptor in cultured interstitial cells of Cajal from murine small intestineSeok Choi
Department of Physiology, College of Medicine, Chosun University, 375 Seosuk dong, Gwangju, South Korea
Cell Physiol Biochem 18:187-98. 2006..2-SUR 2B in ICC and this action of PGE(2) are through EP(2) receptor subtype and also the activation of ATP-dependent K(+) channels involves intracellular Ca(2+) mobilization...
- Prostaglandin receptor EP2 is responsible for cyclooxygenase-2 induction by prostaglandin E2 in mouse skinKausar M Ansari
The University of Texas M D Anderson Cancer Center, Science Park Research Division, PO Box 389, Smithville, TX 78957, USA
Carcinogenesis 28:2063-8. 2007..Taken together, EP2 activation of the PKA/CREB-signaling pathway is responsible for keratinocyte proliferation and our findings reveal a positive feedback loop between COX-2 and PGE2 that is mediated by the EP2 receptor.
- Prostaglandins enhance epidermal growth factor-induced DNA synthesis in hepatocytes by stimulation of E prostanoid 3 and F prostanoid receptorsKristin Meisdalen
Department of Pharmacology, Faculty of Medicine, University of Oslo, P O Box 1057 Blindern, N 0316 Oslo, Norway
J Pharmacol Exp Ther 322:1044-50. 2007..The EP2 receptor agonist butaprost had no significant effect on EGF-induced DNA synthesis...
- Altered hippocampal long-term synaptic plasticity in mice deficient in the PGE2 EP2 receptorHongwei Yang
Neuroscience Center of Excellence, LSU Health Sciences Center, New Orleans, Louisiana, USA
J Neurochem 108:295-304. 2009..previously that PGE2-induced modulation of hippocampal synaptic transmission is via a pre-synaptic PGE2 EP2 receptor. However, little is known about whether the EP2 receptor is involved in hippocampal long-term synaptic ..
- Efferocytosis impairs pulmonary macrophage and lung antibacterial function via PGE2/EP2 signalingAlexandra I Medeiros
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health Systems, Ann Arbor, MI 48109, USA
J Exp Med 206:61-8. 2009..killing by alveolar macrophages and that this is mediated by a cyclooxygenase-PGE(2)-E prostanoid receptor 2 (EP2)-adenylyl cyclase-cyclic AMP pathway...
- Impaired cognition, sensorimotor gating, and hippocampal long-term depression in mice lacking the prostaglandin E2 EP2 receptorA Savonenko
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Exp Neurol 217:63-73. 2009..Recent studies demonstrate an emerging role for the downstream PGE(2) EP2 receptor in diverse models of activity-dependent synaptic plasticity and a significant function in models of ..
- PGE2 signaling through the EP4 receptor on fibroblasts upregulates RANKL and stimulates osteolysisRyosuke Tsutsumi
Center for Musculoskeletal Research, University of Rochester, Rochester, New York, USA
J Bone Miner Res 24:1753-62. 2009..However, the PGE2 receptor (EP1, EP2, or EP4), and cell type in which it is expressed, which is responsible for PGE2 induction of RANKL during wear ..
- Prostaglandin E2-EP4 signaling promotes immune inflammation through Th1 cell differentiation and Th17 cell expansionChengcan Yao
Department of Pharmacology, Faculty of Medicine, Kyoto University, Kyoto, Japan
Nat Med 15:633-40. 2009..Thus, PGE2-EP4 signaling promotes immune inflammation through TH1 differentiation and TH17 expansion, and EP4 antagonism may be therapeutically useful for various immune diseases...
- DOCK2 is a microglial specific regulator of central nervous system innate immunity found in normal and Alzheimer's disease brainPatrick J Cimino
Division of Neuropathology, Department of Pathology, the Neurobiology and Behavior Program, University of Washington, Box 359645, Harborview Medical Center, Seattle, WA 98104, USA
Am J Pathol 175:1622-30. 2009..Previously, the prostaglandin E2 receptor, EP2, was shown to regulate neuroinflammation and reduce Abeta plaque burden in transgenic mice...
- Expression profiling of cumulus cells reveals functional changes during ovulation and central roles of prostaglandin EP2 receptor in cAMP signalingShigero Tamba
Department of Physiological Chemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Sakyo ku, Kyoto 606 8501, Japan
Biochimie 92:665-75. 2010To understand the role of prostaglandin (PG) receptor EP2 (Ptger2) signaling in ovulation and fertilization, we investigated time-dependent expression profiles in wild-type (WT) and Ptger2(-/-) cumuli before and after ovulation by using ..
- CD40 engagement on dendritic cells induces cyclooxygenase-2 and EP2 receptor via p38 and ERK MAPKsHedi Harizi
CNRS UMR 5540, Bordeaux, Universite Bordeaux 2, Bordeaux, France
Immunol Cell Biol 89:275-82. 2011..Collectively, we demonstrated that CD40 engagement on mBM-DC upregulates COX-2 and EP2 receptor expression through activation of p38 and ERK1/2 MAPK signaling...
- EP1(-/-) mice have enhanced osteoblast differentiation and accelerated fracture repairMinjie Zhang
Center for Musculoskeletal Research, University of Rochester, Rochester, NY, USA
J Bone Miner Res 26:792-802. 2011..It has four different receptor subtypes (EP1 through EP4), each of which exerts different effects in bone. EP2 and EP4 induce bone formation through the protein kinase A (PKA) pathway, whereas EP3 inhibits bone formation in ..
- The soluble EP2 receptor FuEP2/Ex2 suppresses endometrial cancer cell growth in an orthotopic xenograft model in nude miceTetsuyuki Takahashi
Department of Molecular and Environmental Pathology, Institute of Health Biosciences, The University of Tokushima Graduate School, Japan
Cancer Lett 306:67-75. 2011..Ish-FuEP2/Ex2 cells expressed FuEP2/Ex2 mRNA and protein. Expression levels of E-prostanoid receptor 1 (EP1), EP2, EP3, EP4, and F-prostanoid receptor (FP) were almost the same in Ish-FuEP2/Ex2 and vector control cells...
- Contribution of peripheral versus central EP1 prostaglandin receptors to inflammatory painTorbjörn Johansson
Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
Neurosci Lett 495:98-101. 2011..Taken together, these results suggest that peripheral EP1 receptors contribute significantly to inflammation induced heat pain sensitization while evidence for a contribution to central sensitization was not obtained...
- Prostaglandin E2 release from astrocytes triggers gonadotropin-releasing hormone (GnRH) neuron firing via EP2 receptor activationJérôme Clasadonte
Institut National de la Sante et de la Recherche Medicale, Jean Pierre Aubert Research Center, U837, Development and Plasticity of the Postnatal Brain, F 59000 Lille, France
Proc Natl Acad Sci U S A 108:16104-9. 2011..These effects are mimicked by an EP2 receptor agonist and attenuated by protein kinase A (PKA) inhibitors...
- Cloning of a novel human prostaglandin receptor with characteristics of the pharmacologically defined EP2 subtypeJ W Regan
Department of Pharmacology and Toxicology, University of Arizona, Tucson 85721
Mol Pharmacol 46:213-20. 1994..Our findings suggest that Hup-4 encodes the pharmacologically defined EP2 receptor, whereas the mouse and human cDNAs previously classified as EP2 may represent another EP receptor subtype or ..
- 'Distinct cellular localization' of the messenger ribonucleic acid for prostaglandin E receptor subtypes in the mouse uterus during pseudopregnancyM Katsuyama
Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Kyoto University, Japan
Endocrinology 138:344-50. 1997..uterine actions of PGE2, expression patterns of the messenger RNAs (mRNAs) for four subtypes of PGE receptors, EP1, EP2, EP3, and EP4, were investigated in the mouse uterus during pseudopregnancy...
- Role of EP(2) and EP(3) PGE(2) receptors in control of murine renal hemodynamicsL P Audoly
Department of Medicine, Duke University and Durham Veterans Affairs Medical Center, Durham, North Carolina 27710, USA
Am J Physiol Heart Circ Physiol 280:H327-33. 2001..We conclude that EP(3 )receptors mediate vasoconstriction in the kidney of male mice and its actions are tonically active in the basal state. Furthermore, EP(3) receptors are capable of buffering PGE(2)-mediated renal vasodilation...
- Diversification of cyclooxygenase-2-derived prostaglandins in ovulation and implantationH Matsumoto
Department of Molecular and Integrative Physiology, Ralph L Smith Research Center, University of Kansas Medical Center, Kansas City, Kansas 66160 7338, USA
Biol Reprod 64:1557-65. 2001....
- CXC CHEMOKINE REGULATION OF PROSTATE CANCER ANGIOGENESISBethany Moore; Fiscal Year: 2002..These studies should lead to new insights into the biology of prostate cancer growth and metastasis, and pave the way to adapt adjuvant therapies for the treatment of this widespread disease. ..
- LIPID PEROXIDATION AND APOE IN ALZHEIMERS DISEASEThomas Montine; Fiscal Year: 2003..This new information will aid in laying the foundation for designing rational therapeutic approaches to ameliorate brain oxidative damage in Alzheimer's disease. ..
- CATECHOL THIOETHERS IN PARKINSON'S DISEASEThomas Montine; Fiscal Year: 2004....
- PGE2 Regulation of Epithelial/Fibroblast InteractionsBethany Moore; Fiscal Year: 2006..Fibrotic alterations to EP2 and/or EP4 receptor expression and/or signaling could abrogate suppressive PGE 2 actions on fibroblasts...
- Characterization of Dementia with Lewy Bodies: A Collaborative StudyThomas Montine; Fiscal Year: 2007..This resource will be made available for future investigations of DLB. ..
- Lipid Oxidation Products in Alzheimer's DiseaseThomas Montine; Fiscal Year: 2007..abstract_text> ..
- Proteomic Discovery in Parkinson-Dementia Complex of GuamThomas Montine; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..