Ptger1

Summary

Gene Symbol: Ptger1
Description: prostaglandin E receptor 1 (subtype EP1)
Alias: 42kDa, EP1, Ptgerep1, prostaglandin E2 receptor EP1 subtype, PGE receptor EP1 subtype, PGE2 receptor EP1 subtype, prostanoid EP1 receptor
Species: mouse

Top Publications

  1. ncbi Prostanoid receptors: structures, properties, and functions
    S Narumiya
    Department of Pharmacology, Kyoto University Faculty of Medicine, Kyoto, Japan
    Physiol Rev 79:1193-226. 1999
  2. pmc The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut
    Kenji Kabashima
    Department of Pharmacology, Faculty of Medicine, Kyoto University, Kyoto, Japan
    J Clin Invest 109:883-93. 2002
  3. pmc The role of prostaglandin E2 receptors in the pathogenesis of rheumatoid arthritis
    Jennifer M McCoy
    Pfizer Global Research and Development, Department of Inflammation and Pathology, Groton, Connecticut 06340, USA
    J Clin Invest 110:651-8. 2002
  4. pmc Receptors for prostaglandin E(2) that regulate cellular immune responses in the mouse
    C Nataraj
    Division of Nephrology, Duke University and Durham Veterans Affairs Medical Centers, Durham, NC 27705, USA
    J Clin Invest 108:1229-35. 2001
  5. pmc Impaired adrenocorticotropic hormone response to bacterial endotoxin in mice deficient in prostaglandin E receptor EP1 and EP3 subtypes
    Yoko Matsuoka
    Department of Pharmacology, Kyoto University Faculty of Medicine, Kyoto 606 8501, Japan
    Proc Natl Acad Sci U S A 100:4132-7. 2003
  6. ncbi Prostaglandin E2-EP4 signaling initiates skin immune responses by promoting migration and maturation of Langerhans cells
    Kenji Kabashima
    Department of Pharmacology, Kyoto University Faculty of Medicine, Kyoto 606 8501, Japan
    Nat Med 9:744-9. 2003
  7. pmc The prostaglandin E2 EP1 receptor mediates pain perception and regulates blood pressure
    J L Stock
    Genetic Technologies, Pfizer Global Research and Development, Groton, Connecticut 06340, USA
    J Clin Invest 107:325-31. 2001
  8. ncbi Suppression of allergic inflammation by the prostaglandin E receptor subtype EP3
    Tomonori Kunikata
    Department of Pharmacology and Faculty of Medicine and Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606 8501, Japan
    Nat Immunol 6:524-31. 2005
  9. ncbi Dominant role of prostaglandin E2 EP4 receptor in furosemide-induced salt-losing tubulopathy: a model for hyperprostaglandin E syndrome/antenatal Bartter syndrome
    Rolf M Nusing
    Institute of Clinical Pharmacology, Johann Wolfgang Goethe University, Theodor Stern Kai 7, Frankfurt 60590, Germany
    J Am Soc Nephrol 16:2354-62. 2005
  10. ncbi Age-induced reprogramming of mast cell degranulation
    MyTrang Nguyen
    Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA
    J Immunol 175:5701-7. 2005

Research Grants

Scientific Experts

  • Koji Takeuchi
  • Asheebo Rojas
  • B B Moore
  • Karin Muller-Decker
  • Toshihiko Kawamori
  • Chris R J Kennedy
  • F Schweda
  • Ichiro Takasaki
  • Niklas Kern
  • Youfei Guan
  • Kenji Kabashima
  • Chang Han
  • Shuh Narumiya
  • Tomoyuki Furuyashiki
  • SYLVAIN DORE
  • Toshiyuki Matsuoka
  • Richard M Breyer
  • S Narumiya
  • Takayuki Maruyama
  • Inok Surh
  • Rania Nasrallah
  • Y Sugimoto
  • Shiho Kitaoka
  • Daiji Sakata
  • Eri Segi-Nishida
  • Fumitaka Ushikubi
  • Jonathan Hoggatt
  • Pratibha Singh
  • F Ushikubi
  • Yasuhiro Tanaka
  • Gang Wang
  • Minjie Zhang
  • Chengcan Yao
  • Yukihiko Sugimoto
  • Matthew D Breyer
  • Kitipong Soontrapa
  • A Ichikawa
  • Yoko Matsuoka
  • Damian C Genetos
  • Christina M Lee
  • Tetsuya Honda
  • Rolf M Nusing
  • Jan C Frankowski
  • Alexander V Glushakov
  • Grace O'Callaghan
  • Abdullah Shafique Ahmad
  • Aliza T Ehrlich
  • Peirong Hu
  • Louis M Pelus
  • Jennifer M Speth
  • Kohei Tanaka
  • Christina S Bartlett
  • Stefanie Frölich
  • Gehua Zhen
  • Koji Takayama
  • Takayuki Fujino
  • Amy Pavone
  • Carol Mikulec
  • Erika Abel
  • Susan M Fischer
  • MyTrang Nguyen
  • Torbjörn Johansson
  • Chihiro Suzuki
  • Angus Stock
  • Richard L Hébert
  • Lisa M Flick
  • REGIS J O'KEEFE
  • Yoshiyasu Esaki
  • Hiroshi Katoh
  • Yoshihiro Kita
  • Edward M Schwarz
  • Takao Shimizu
  • Rung Chi Li
  • Josef Anrather
  • Ping Zhou
  • Costantino Iadecola
  • Tomohiro Kitamura
  • C Dirk Keene
  • Ibolya Rutkai
  • Ryosuke Tsutsumi
  • Toru Oga
  • Xiaojun Wang
  • Clare E Yellowley
  • Masataka Majima
  • Sofiyan Saleem
  • Miyako Nagamachi
  • S Biswas
  • Yoshiki Miyachi
  • Hitoshi Shichi
  • Tetsuro Kayahara

Detail Information

Publications87

  1. ncbi Prostanoid receptors: structures, properties, and functions
    S Narumiya
    Department of Pharmacology, Kyoto University Faculty of Medicine, Kyoto, Japan
    Physiol Rev 79:1193-226. 1999
    ..In this article, we summarize these findings and attempt to give an overview of the current status of research on the prostanoid receptors...
  2. pmc The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut
    Kenji Kabashima
    Department of Pharmacology, Faculty of Medicine, Kyoto University, Kyoto, Japan
    J Clin Invest 109:883-93. 2002
    ..Among the prostanoid receptor-deficient mice, only EP4-deficient mice and not mice deficient in either DP, EP1, EP2, EP3, FP, IP, or TP developed severe colitis with 3% DSS treatment, which induced only marginal colitis in ..
  3. pmc The role of prostaglandin E2 receptors in the pathogenesis of rheumatoid arthritis
    Jennifer M McCoy
    Pfizer Global Research and Development, Department of Inflammation and Pathology, Groton, Connecticut 06340, USA
    J Clin Invest 110:651-8. 2002
    ..Homozygous deletion of the EP1, EP2, or EP3 receptors did not affect the development of arthritis, whereas EP4 receptor-deficient mice showed ..
  4. pmc Receptors for prostaglandin E(2) that regulate cellular immune responses in the mouse
    C Nataraj
    Division of Nephrology, Duke University and Durham Veterans Affairs Medical Centers, Durham, NC 27705, USA
    J Clin Invest 108:1229-35. 2001
    ..There are four receptors for PGE(2) (EP1-EP4) with unique patterns of expression and different coupling to intracellular signaling pathways...
  5. pmc Impaired adrenocorticotropic hormone response to bacterial endotoxin in mice deficient in prostaglandin E receptor EP1 and EP3 subtypes
    Yoko Matsuoka
    Department of Pharmacology, Kyoto University Faculty of Medicine, Kyoto 606 8501, Japan
    Proc Natl Acad Sci U S A 100:4132-7. 2003
    ..By using mice lacking each of the four PGE receptors (EP1-EP4) and an EP1-selective antagonist, ONO-8713, we showed that both EP1 and EP3 are required for ..
  6. ncbi Prostaglandin E2-EP4 signaling initiates skin immune responses by promoting migration and maturation of Langerhans cells
    Kenji Kabashima
    Department of Pharmacology, Kyoto University Faculty of Medicine, Kyoto 606 8501, Japan
    Nat Med 9:744-9. 2003
    ..PGE2-EP4 signaling thus facilitates initiation of skin immune responses by promoting the migration and maturation of Langerhans cells...
  7. pmc The prostaglandin E2 EP1 receptor mediates pain perception and regulates blood pressure
    J L Stock
    Genetic Technologies, Pfizer Global Research and Development, Groton, Connecticut 06340, USA
    J Clin Invest 107:325-31. 2001
    ..Four different receptor subtypes (EP1-4) mediate these wide-ranging effects...
  8. ncbi Suppression of allergic inflammation by the prostaglandin E receptor subtype EP3
    Tomonori Kunikata
    Department of Pharmacology and Faculty of Medicine and Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606 8501, Japan
    Nat Immunol 6:524-31. 2005
    ..Thus, the PGE(2)-EP3 pathway is an important negative modulator of allergic reactions...
  9. ncbi Dominant role of prostaglandin E2 EP4 receptor in furosemide-induced salt-losing tubulopathy: a model for hyperprostaglandin E syndrome/antenatal Bartter syndrome
    Rolf M Nusing
    Institute of Clinical Pharmacology, Johann Wolfgang Goethe University, Theodor Stern Kai 7, Frankfurt 60590, Germany
    J Am Soc Nephrol 16:2354-62. 2005
    ..In wild-type (WT) mice and in mice lacking distinct PGE2 receptors (EP1-/-, EP2-/-, EP3-/-, and EP4-/-), the effect of chronic furosemide administration (7 d) on urine output, sodium and ..
  10. ncbi Age-induced reprogramming of mast cell degranulation
    MyTrang Nguyen
    Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA
    J Immunol 175:5701-7. 2005
    ..Therefore, elevated PGE2 levels might provide an important pathway by which mast cells are engaged to participate in inflammatory responses in the elderly patient...
  11. ncbi Prostaglandin E2 EP1 receptors: downstream effectors of COX-2 neurotoxicity
    Takayuki Kawano
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, New York 10021, USA
    Nat Med 12:225-9. 2006
    ..We therefore sought to identify the downstream effectors of COX-2 neurotoxicity, and found that prostaglandin E(2) EP1 receptors are essential for the neurotoxicity mediated by COX-2-derived prostaglandin E(2)...
  12. ncbi Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3
    F Ushikubi
    Department of Pharmacology, Faculty of Medicine, Kyoto University, Japan
    Nature 395:281-4. 1998
    ..PGE2 acts by interacting with four subtypes of PGE receptor, the EP1, EP2, EP3 and EP4 receptors. Here we generate mice lacking each of these receptors by homologous recombination...
  13. pmc Effects of EP1 receptor on cerebral blood flow in the middle cerebral artery occlusion model of stroke in mice
    Sofiyan Saleem
    Department of Anesthesiology Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci Res 85:2433-40. 2007
    ..Thus, the prostanoid EP1 receptor plays a significant role in regulating CBF and neuronal cell death...
  14. pmc Antihypertensive effects of selective prostaglandin E2 receptor subtype 1 targeting
    Youfei Guan
    Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    J Clin Invest 117:2496-505. 2007
    ..The present studies were aimed at elucidating the role of prostaglandin E2 (PGE2) E-prostanoid receptor subtype 1 (EP1) in regulating blood pressure...
  15. ncbi The mouse genes for the EP1 prostanoid receptor and the PKN protein kinase overlap
    B Båtshake
    Division of Molecular Neurobiology, Wallenberg Neurocentre, Lund University, Sweden
    Biochem Biophys Res Commun 227:70-6. 1996
    ..We show in this report that the mouse PKN gene is situated at the mouse EP1 prostanoid receptor gene locus and that the two genes are overlapping in a tail-to-tail manner...
  16. pmc PGE2 EP1 receptor exacerbated neurotoxicity in a mouse model of cerebral ischemia and Alzheimer's disease
    Gehua Zhen
    Department of Anesthesiology Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Neurobiol Aging 33:2215-9. 2012
    ..Our study was designed to delineate the prostaglandin E(2) EP1 receptor role in AD and in the setting of cerebral ischemia...
  17. pmc Detrimental role of the EP1 prostanoid receptor in blood-brain barrier damage following experimental ischemic stroke
    Jan C Frankowski
    Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA
    Sci Rep 5:17956. 2015
    ..This study aimed to investigate the role of PGE2 EP1 receptor in neurovascular injury in stroke...
  18. doi Prostaglandin E receptor EP1 forms a complex with dopamine D1 receptor and directs D1-induced cAMP production to adenylyl cyclase 7 through mobilizing G(βγ) subunits in human embryonic kidney 293T cells
    Aliza T Ehrlich
    Medical Innovation Center, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Mol Pharmacol 84:476-86. 2013
    ..We previously reported that prostaglandin E receptor EP1 facilitates dopamine D1 receptor signaling in striatal slices and promotes behavioral responses induced by D1 ..
  19. pmc COX-1-derived PGE2 and PGE2 type 1 receptors are vital for angiotensin II-induced formation of reactive oxygen species and Ca(2+) influx in the subfornical organ
    Gang Wang
    The Brain and Mind Research Institute, Weill Cornell Medical College, New York, New York
    Am J Physiol Heart Circ Physiol 305:H1451-61. 2013
    ..Our findings provide the first evidence of a spatial and functional framework that underlies ANG-II signaling in the SFO and reveal novel targets for antihypertensive therapies...
  20. pmc Role of the prostaglandin E2 EP1 receptor in traumatic brain injury
    Alexander V Glushakov
    Department of Anesthesiology, University of Florida College of Medicine, Gainesville, Florida, United States of America
    PLoS ONE 9:e113689. 2014
    ..prostaglandin E2 (PGE2), leading to overactivation of a class of its cognate G-protein-coupled receptors, including EP1, which is considered a promising target for treatment of ischemic stroke...
  21. doi Prostaglandin E2 increases proximal tubule fluid reabsorption, and modulates cultured proximal tubule cell responses via EP1 and EP4 receptors
    Rania Nasrallah
    Department of Cellular and Molecular Medicine, Kidney Research Centre, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada
    Lab Invest 95:1044-55. 2015
    Renal prostaglandin (PG) E2 regulates salt and water transport, and affects disease processes via EP1-4 receptors, but its role in the proximal tubule (PT) is unknown...
  22. pmc Local abnormalities in coagulation and fibrinolytic pathways predispose to alveolar fibrin deposition in the adult respiratory distress syndrome
    S Idell
    Department of Medicine, University of Texas Health Center, Tyler 75710
    J Clin Invest 84:695-705. 1989
    ..We conclude that abnormalities that result in enhanced coagulation and depressed fibrinolysis, thereby predisposing to alveolar fibrin deposition, occur in the alveolar lining fluids from patients with ARDS...
  23. ncbi Involvement of prostaglandin E receptor subtype EP(4) in colon carcinogenesis
    Michihiro Mutoh
    Cancer Prevention Division, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    Cancer Res 62:28-32. 2002
    ....
  24. pmc EP1(-/-) mice have enhanced osteoblast differentiation and accelerated fracture repair
    Minjie Zhang
    Center for Musculoskeletal Research, University of Rochester, Rochester, NY, USA
    J Bone Miner Res 26:792-802. 2011
    ..It has four different receptor subtypes (EP1 through EP4), each of which exerts different effects in bone...
  25. pmc Differential stem- and progenitor-cell trafficking by prostaglandin E2
    Jonathan Hoggatt
    Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Nature 495:365-9. 2013
    ..These results not only uncover unique regulatory roles for EP4 signalling in HSC retention in the niche, but also define a rapidly translatable strategy to enhance transplantation therapeutically...
  26. doi Targeting the EP1 receptor reduces Fas ligand expression and increases the antitumor immune response in an in vivo model of colon cancer
    Grace O'Callaghan
    Department of Medicine, University College Cork, Cork, Ireland
    Int J Cancer 133:825-34. 2013
    ..PGE2 signals through four different receptors (EP1-EP4) and targeting individual receptor(s) may avoid these side effects, while retaining significant anticancer ..
  27. pmc PGE2 EP1 receptor deletion attenuates 6-OHDA-induced Parkinsonism in mice: old switch, new target
    Abdullah Shafique Ahmad
    Department of Anesthesiology, University of Florida College of Medicine, PO Box 100159, Gainesville, FL 32610 0254, USA
    Neurotox Res 23:260-6. 2013
    ..and plays an important role in various physiologic and pathophysiologic conditions through its EP receptors (EP1-EP4)...
  28. pmc EP1 disruption attenuates end-organ damage in a mouse model of hypertension
    Christina S Bartlett
    Department of Pharmacology, Vanderbilt University Medical Center, 1161 21 Ave, Medical Center North B3214, Nashville, TN 37232 2372, USA
    Hypertension 60:1184-91. 2012
    ..The prostaglandin E(2) receptor EP1 has been shown to contribute to hypertension by mediating angiotensin II-dependent vasoconstriction, although its ..
  29. doi Temporal expression of the PGE2 synthetic system in the kidney is associated with the time frame of renal developmental vulnerability to cyclooxygenase-2 inhibition
    Stefanie Frölich
    Institute of Clinical Pharmacology, Johann Wolfgang Goethe University, Theodor Stern Kai 7, Frankfurt, Germany
    Am J Physiol Renal Physiol 303:F209-19. 2012
    ..Studying glomerulogenesis in EP receptor knockout mice revealed a reduction in glomerular size in EP1(-/-), EP2(-/-), and EP4(-/-) mice, supporting the developmental role of PGE(2)...
  30. pmc Prostaglandin E2-mediated attenuation of mesocortical dopaminergic pathway is critical for susceptibility to repeated social defeat stress in mice
    Kohei Tanaka
    Department of Pharmacology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Neurosci 32:4319-29. 2012
    ..PGE(2) level in the subcortical region of the brain, and mice lacking either COX-1, a prostaglandin synthase, or EP1, a PGE receptor, were impaired in induction of social avoidance by repeated social defeat...
  31. pmc Blockade of prostaglandin E2 signaling through EP1 and EP3 receptors attenuates Flt3L-dependent dendritic cell development from hematopoietic progenitor cells
    Pratibha Singh
    Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Blood 119:1671-82. 2012
    ..PGE(2) regulation of DC generation is specifically mediated through the EP1 and EP3 G protein PGE(2) receptors...
  32. pmc The EP1 receptor for prostaglandin E2 promotes the development and progression of malignant murine skin tumors
    Inok Surh
    The University of Texas MD Anderson Cancer Center, Department of Molecular Carcinogenesis, Science Park, Smithville, TX 78957, USA
    Mol Carcinog 51:553-64. 2012
    ..This effect of PGE2 is likely mediated by one or more of its 4 G-protein coupled membrane receptors, EP1-4. A previous study showed that BK5...
  33. doi Prostaglandin E receptor EP1 enhances GABA-mediated inhibition of dopaminergic neurons in the substantia nigra pars compacta and regulates dopamine level in the dorsal striatum
    Yasuhiro Tanaka
    Department of Pharmacology, Kyoto University Graduate School of Medicine, Sakyo ku, Kyoto, Japan
    Eur J Neurosci 30:2338-46. 2009
    ..We previously found that mice lacking prostaglandin E receptor EP1 showed impulsive emotional behaviors accompanied by enhanced DA turnover in the frontal cortex and striatum...
  34. pmc Prostaglandin E2 suppresses the differentiation of retinoic acid-producing dendritic cells in mice and humans
    Angus Stock
    Medical Research Council Human Immunology Unit, Nuffield Department of Medicine, MRC Weatherall Institute of Molecular Medicine, University of Oxford, OX3 9DS Oxford, England, UK
    J Exp Med 208:761-73. 2011
    ..Given the role of PGE2 in regulating the development of RA-producing DCs, modulating this pathway may prove a novel means to control the development of gut-tropic immune responses...
  35. pmc PGE2 signaling through the EP4 receptor on fibroblasts upregulates RANKL and stimulates osteolysis
    Ryosuke Tsutsumi
    Center for Musculoskeletal Research, University of Rochester, Rochester, New York, USA
    J Bone Miner Res 24:1753-62. 2009
    ..However, the PGE2 receptor (EP1, EP2, or EP4), and cell type in which it is expressed, which is responsible for PGE2 induction of RANKL during wear ..
  36. pmc Protection of hippocampal neurogenesis from toll-like receptor 4-dependent innate immune activation by ablation of prostaglandin E2 receptor subtype EP1 or EP2
    C Dirk Keene
    Department of Pathology, University of Washington, Box 359791, Seattle, WA 98104, USA
    Am J Pathol 174:2300-9. 2009
    ..The prostaglandin E2 receptor family consists of four subtypes of which EP1 and EP2 are known to be expressed by microglia...
  37. pmc Activation of prostaglandin E2 EP1 receptor increases arteriolar tone and blood pressure in mice with type 2 diabetes
    Ibolya Rutkai
    Division of Clinical Physiology, Institute of Cardiology, University of Debrecen, Debrecen, Hungary
    Cardiovasc Res 83:148-54. 2009
    ..We tested the hypothesis that activation of type 1 prostaglandin E(2) (PGE(2)) receptor (EP1) increases skeletal muscle arteriolar tone and blood pressure in mice with type 2 diabetes.
  38. pmc HIF-1alpha regulates hypoxia-induced EP1 expression in osteoblastic cells
    Damian C Genetos
    Department of Surgical and Radiological Sciences, University of California at Davis, 95616, USA
    J Cell Biochem 107:233-9. 2009
    ..have previously demonstrated that hypoxic osteoblasts increase PGE(2) release and expression of the PGE(2) receptor EP1. In the present studies, we investigated the impact of altered HIF-1alpha activity and expression on EP1 expression ..
  39. pmc Transgenic expression of cyclooxygenase-2 in hepatocytes accelerates endotoxin-induced acute liver failure
    Chang Han
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Immunol 181:8027-35. 2008
    ..Therefore, blocking COX-2-EP(1) pathway may represent a potential approach for amelioration of LPS-induced liver injury...
  40. ncbi Urothelium EP1 receptor facilitates the micturition reflex in mice
    Xiaojun Wang
    Department of Neurophysiology, Akita University, School of Medicine, Akita, Japan
    Biomed Res 29:105-11. 2008
    We investigated the presence of EP1 receptor in the urothelium and its role in micturition reflex by examining the effect of intravesical administration of prostaglandin E(2) (PGE2), an EP1 agonist (ONO-DI-004), acetic acid, and ..
  41. pmc Facilitation of Th1-mediated immune response by prostaglandin E receptor EP1
    Miyako Nagamachi
    Department of Pharmacology, Faculty of Medicine, Kyoto University, Kyoto 606 8501, Japan
    J Exp Med 204:2865-74. 2007
    Prostaglandin E2 (PGE2) exerts its actions via four subtypes of the PGE receptor, EP1-4...
  42. ncbi Potential sites of prostaglandin actions in the periimplantation mouse uterus: differential expression and regulation of prostaglandin receptor genes
    Z M Yang
    Department of Physiology, Ralph L Smith Research Center, University of Kansas Medical Center, Kansas City 66160 7336, USA
    Biol Reprod 56:368-79. 1997
    ..PGE2 receptors are classified into four subtypes, EP1, EP2, EP3, and EP4...
  43. ncbi Cyclooxygenase 2- and prostaglandin E(2) receptor EP(2)-dependent angiogenesis in Apc(Delta716) mouse intestinal polyps
    Hiroshi Seno
    Department of Pharmacology, Kyoto University Graduate School of Medicine, Kyoto 606 8501, Japan
    Cancer Res 62:506-11. 2002
    ....
  44. pmc COX-2 and prostaglandin EP3/EP4 signaling regulate the tumor stromal proangiogenic microenvironment via CXCL12-CXCR4 chemokine systems
    Hiroshi Katoh
    Department of Pharmacology, Kitasato University, School of Medicine, Kitasato 1 15 1, Sagamihara, Kanagawa, 228 8555, Japan
    Am J Pathol 176:1469-83. 2010
    ....
  45. pmc Dual roles of PGE2-EP4 signaling in mouse experimental autoimmune encephalomyelitis
    Yoshiyasu Esaki
    Departments of Pharmacology and Anesthesiology, Faculty of Medicine, Kyoto University, Kyoto 606 8501, Japan
    Proc Natl Acad Sci U S A 107:12233-8. 2010
    ....
  46. doi Upregulation of the EP1 receptor for prostaglandin E2 promotes skin tumor progression
    Inok Surh
    The University of Texas MD Anderson Cancer Center, Science Park Research Division, Smithville, Texas 78957, USA
    Mol Carcinog 50:458-68. 2011
    Prostaglandin E(2) (PGE(2) ) has been shown to promote the development of murine skin tumors. EP1 is 1 of the 4 PGE(2) G-protein-coupled membrane receptors expressed by murine keratinocytes...
  47. doi Contribution of peripheral versus central EP1 prostaglandin receptors to inflammatory pain
    Torbjörn Johansson
    Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Neurosci Lett 495:98-101. 2011
    ..Among the PGE(2) receptors, the EP1 subtype has repeatedly been proposed as a promising target for treatment of inflammatory hyperalgesia...
  48. ncbi Cellular localization of mRNAs for prostaglandin E receptor subtypes in mouse gastrointestinal tract
    K Morimoto
    Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Kyoto University, Japan
    Am J Physiol 272:G681-7. 1997
    ..Strong signals for EP1 transcripts were detected in cells of the muscularis mucosae layer, especially in the body of the stomach...
  49. pmc Prostaglandin E2-prostaglandin E receptor subtype 4 (EP4) signaling mediates UV irradiation-induced systemic immunosuppression
    Kitipong Soontrapa
    Department of Pharmacology, Kyoto University Faculty of Medicine, Kyoto 606 8501, Japan
    Proc Natl Acad Sci U S A 108:6668-73. 2011
    ..Thus, prostaglandin E(2) (PGE(2))-EP4 signaling mediates UV-induced immunosuppression by elevating the number of Treg cells through regulation of RANKL expression in the epidermis...
  50. doi Central PGE2 exhibits anxiolytic-like activity via EP1 and EP4 receptors in a manner dependent on serotonin 5-HT1A, dopamine D1 and GABAA receptors
    Chihiro Suzuki
    Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Gokasho Uji, Kyoto, Japan
    FEBS Lett 585:2357-62. 2011
    ..Taken together, PGE(2) exhibits anxiolytic-like activity via EP(1) and EP(4) receptors, with downstream involvement of 5-HT(1A), D(1) and GABA(A) receptor systems...
  51. ncbi Characterization and regulation of prostaglandin E2 receptors on normal and malignant murine B lymphocytes
    D M Brown
    Department of Microbiology and Immunology, University of Rochester, School of Medicine and Dentistry, New York 14642
    Cell Immunol 161:79-87. 1995
    ..Moreover, these observations may be of importance in developing strategies to specifically control the spread of PGE2-sensitive B lymphomas...
  52. ncbi Molecular characterization of the mouse prostanoid EP1 receptor gene
    B Båtshake
    Division of Molecular Neurobiology, Wallenberg Laboratory, Lund University, Sweden
    Eur J Biochem 231:809-14. 1995
    A partial cDNA, corresponding to the mouse prostaglandin E2 receptor subtype EP1, was isolated from mouse brain cDNA using a degenerate primer PCR strategy...
  53. ncbi Studies on the induction of cyclooxygenase isozymes by various prostaglandins in mouse osteoblastic cell line with reference to signal transduction pathways
    Y Takahashi
    Department of Biochemistry, Tokushima University School of Medicine, Japan
    Biochim Biophys Acta 1212:217-24. 1994
    ....
  54. ncbi Bleomycin-induced E prostanoid receptor changes alter fibroblast responses to prostaglandin E2
    Bethany B Moore
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 174:5644-9. 2005
    ..EP2(-/-), but not EP1(-/-) or EP3(-/-) mice, showed exaggerated fibrotic responses to bleomycin administration in vivo as compared with ..
  55. ncbi Gastric ulcerogenic responses following barrier disruption in knockout mice lacking prostaglandin EP1 receptors
    K Takeuchi
    Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Misasagi, Yamashina, Japan
    Aliment Pharmacol Ther 16:74-82. 2002
    ..In the present study, we evaluated the mucosal ulcerogenic and mucosal blood flow (GMBF) responses in the stomach after damage by taurocholate (TC) in knockout mice lacking EP1 or EP3 receptors.
  56. ncbi Facilitation by endogenous prostaglandins of capsaicin-induced gastric protection in rodents through EP2 and IP receptors
    Koji Takeuchi
    Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Kyoto, Japan
    J Pharmacol Exp Ther 304:1055-62. 2003
    ..The effect of PGE(2) was antagonized by ONO-AE-829 (EP1 antagonist), whereas the capsaicin action was mitigated by indomethacin as well as sensory deafferentation but not ..
  57. ncbi Receptors and pathways mediating the effects of prostaglandin E2 on airway tone
    Stephen L Tilley
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of North Carolina at Chapel Hill, 27599 7248, USA
    Am J Physiol Lung Cell Mol Physiol 284:L599-606. 2003
    ..In conscious mice the administration of PGE(2) increased airway responsiveness primarily through the EP1 receptor, although on certain genetic backgrounds a contribution of the EP3 receptor was detected...
  58. ncbi Acceleration of intestinal polyposis through prostaglandin receptor EP2 in Apc(Delta 716) knockout mice
    M Sonoshita
    Laboratory of Biomedical Genetics, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan
    Nat Med 7:1048-51. 2001
    ..Homozygous gene knockout for other PGE(2) receptors, EP1 or EP3, did not affect intestinal polyp formation in Apc(Delta 716) mice...
  59. pmc Characterization of EP receptor subtypes responsible for prostaglandin E2-induced pain responses by use of EP1 and EP3 receptor knockout mice
    T Minami
    Department of Anesthesiology, Osaka Medical College, Takatsuki 569 8686, Japan
    Br J Pharmacol 133:438-44. 2001
    ..PGE receptor (EP) subtypes that mediate pain responses to noxious and innocuous stimuli, we studied them by use of EP1 and EP3 knockout (EP1(-/-) and EP3(-/-)) mice...
  60. pmc Characteristics of thermoregulatory and febrile responses in mice deficient in prostaglandin EP1 and EP3 receptors
    Takakazu Oka
    Department of Neurology, Beth Israel Deaconess Medical Center and Program in Neuroscience and Harvard Medical School, Boston, MA 02115, USA
    J Physiol 551:945-54. 2003
    Previous studies have disagreed about whether prostaglandin EP1 or EP3 receptors are critical for producing febrile responses...
  61. ncbi Stimulation of renin release by prostaglandin E2 is mediated by EP2 and EP4 receptors in mouse kidneys
    Frank Schweda
    Institute for Physiology, University of Regensburg, 93042 Regensburg, Germany
    Am J Physiol Renal Physiol 287:F427-33. 2004
    ..In contrast, all four receptor subtypes are involved in the control of renal vascular tone, EP(1) and EP(3) receptors increasing, and EP(2) as well as EP(4) receptors, decreasing it...
  62. pmc Decreased susceptibility to renovascular hypertension in mice lacking the prostaglandin I2 receptor IP
    Takayuki Fujino
    Department of Pharmacology, Asahikawa Medical College, Japan
    J Clin Invest 114:805-12. 2004
    ..These results indicate that PGI2 derived from COX-2 plays a critical role in regulating the release of renin and consequently renovascular hypertension in vivo...
  63. ncbi Prostaglandin E receptor subtype EP(1) deficiency inhibits colon cancer development
    Toshihiko Kawamori
    Cancer Prevention Basic Research Project, National Cancer Center Research Institute, 1 1 Tsukiji 5 chome, Chuo Ku, Tokyo 104 0045, Japan
    Carcinogenesis 26:353-7. 2005
    ..These results provide strong evidence that the EP(1) receptor is of major importance for colon cancer development and it could be a new target for a mechanism-based chemoprevention strategy against colon cancer development...
  64. ncbi Impaired bone resorption to prostaglandin E2 in prostaglandin E receptor EP4-knockout mice
    C Miyaura
    Department of Biochemistry, School of Dentistry, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    J Biol Chem 275:19819-23. 2000
    ..and then identified PGE receptor subtype(s) mediating this PGE(2) action using mice lacking each subtype (EP1, EP2, EP3, and EP4) of PGE receptor...
  65. ncbi Thromboxane A2 and prostaglandin F2alpha mediate inflammatory tachycardia
    Koji Takayama
    Department of Pharmacology, Asahikawa Medical College, Midorigaoka Higashi 2 1 1 1, Asahikawa 078 8510, Japan
    Nat Med 11:562-6. 2005
    ..Our results show that inflammatory tachycardia is caused by a direct action on the heart of TXA(2) and PGF(2alpha) formed under systemic inflammatory conditions...
  66. pmc Hypoxia regulates PGE(2) release and EP1 receptor expression in osteoblastic cells
    Christina M Lee
    Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California at Davis, Davis, California 95616, USA
    J Cell Physiol 212:182-8. 2007
    ..Cells cultured in 2% O(2) showed activation of the HRE, increased PGE(2) release, increased EP1 expression, and reduced cell proliferation compared to cells grown at 21% O(2)...
  67. ncbi Involvement of cyclooxygenase-2 and EP3 prostaglandin receptor in acute herpetic but not postherpetic pain in mice
    Ichiro Takasaki
    Department of Applied Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Neuropharmacology 49:283-92. 2005
    ..Deficiency in EP3 but not EP1, IP or TP prostanoid receptor markedly diminished the acute herpetic pain and resulted in the decrease of the ..
  68. ncbi Anorexia and cachexia in prostaglandin EP1 and EP3 subtype receptor knockout mice bearing a tumor with high intrinsic PGE2 production and prostaglandin related cachexia
    W Wang
    Dept of Surgery, Surgical Metabolic Research Laboratory at Lundberg Laboratory for Cancer Research, Sahlgrenska University Hospital, Goteborg, Sweden
    J Exp Clin Cancer Res 24:99-107. 2005
    ..In the present study, we investigated the role of PGE receptors subtype EP1 and EP3 on the development of anorexia in MCG 101-bearing mice...
  69. ncbi Role of the prostaglandin E receptor subtype EP1 in colon carcinogenesis
    K Watanabe
    Cancer Prevention Division, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Res 59:5093-6. 1999
    ..preneoplastic lesions of the colon, in two lines of knockout mice, each deficient in prostaglandin E receptors, EP1 and EP3, by treatment with the colon carcinogen, azoxymethane...
  70. ncbi Increased severity of renal impairment in nephritic mice lacking the EP1 receptor
    Sherine Rahal
    Kidney Research Centre, Molecular Medicine Program, Ottawa Health Research Institute, Division of Nephrology, Ottawa Hospital and University of Ottawa, 451 Smyth Road, Rm 1317, Ottawa, Ontario K1H 8M5, Canada
    Can J Physiol Pharmacol 84:877-85. 2006
    ..We investigated the role of the PGE2 EP1 receptor in nephritis since it is expressed in the glomerulus, collecting duct and vasculature in which its ..
  71. ncbi Prostaglandin E2 is required for ultraviolet B-induced skin inflammation via EP2 and EP4 receptors
    Kenji Kabashima
    Department of Pharmacology, Kyoto University Graduate School of Medicine, Sakyo, Kyoto, Japan
    Lab Invest 87:49-55. 2007
    ..These data suggest that PGE(2)-EP2/EP4 signaling is mandatory in UV-induced acute skin inflammation, presumably by enhancing blood flow in the microenvironment...
  72. ncbi Modulation of ocular inflammatory responses by EP1 receptors in mice
    S Biswas
    Department of Ophthalmology and Visual Science, University of Louisville, 301E Muhammad Ali Blvd, Louisville, KY 40202, USA
    Exp Eye Res 84:39-43. 2007
    The purpose of the study was to investigate the role of EP1 receptors in intraocular inflammation and to determine possible interplay between EP1, EP2 and EP4 receptors...
  73. pmc Recruitment of a prostaglandin E receptor subtype, EP3-expressing bone marrow cells is crucial in wound-induced angiogenesis
    Emi Kamoshita
    Department of Pharmacology, Kitasato University School of Medicine, Kanagawa 228 8555, Japan
    Am J Pathol 169:1458-72. 2006
    ..knockout mice (EP3-/-) were significantly delayed compared with their wild-type (WT) mice, whereas those in EP1-/-, EP2-/-, and EP4-/- were not delayed...
  74. ncbi Renal prostaglandin E2 receptor (EP) expression profile is altered in streptozotocin and B6-Ins2Akita type I diabetic mice
    Rania Nasrallah
    Department of Cellular and Molecular Medicine, Kidney Research Centre, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada
    Am J Physiol Renal Physiol 292:F278-84. 2007
    ..Therefore, knowing the pattern of change in relative EP receptor expression in the kidney could be useful in identifying specific EP targets for the prevention of various components of diabetic kidney disease...
  75. ncbi Urine concentrating defect in prostaglandin EP1-deficient mice
    Chris R J Kennedy
    Department of Medicine, Ottawa Hospital, Ontario, Canada
    Am J Physiol Renal Physiol 292:F868-75. 2007
    ..These data suggest that PGE(2) modulates urine concentration by acting at EP(1) receptors, not in the collecting duct, but within the hypothalamus to promote AVP synthesis in response to acute WD...
  76. ncbi The effects of prostaglandin analogues on prostanoid EP1, EP2, and EP3 receptor-deficient mice
    Takashi Ota
    Department of Ophthalmology, University of Tokyo School of Medicine, Japan
    Invest Ophthalmol Vis Sci 47:3395-9. 2006
    ..To determine the role of prostanoid EP receptors in the intraocular pressure (IOP)-lowering effect of prostaglandin analogues in EP receptor-deficient mice...
  77. pmc Airway smooth muscle prostaglandin-EP1 receptors directly modulate beta2-adrenergic receptors within a unique heterodimeric complex
    Dennis W McGraw
    Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    J Clin Invest 116:1400-9. 2006
    ..This mechanism may contribute to beta-agonist resistance found in asthma...
  78. pmc Prostacyclin-IP signaling and prostaglandin E2-EP2/EP4 signaling both mediate joint inflammation in mouse collagen-induced arthritis
    Tetsuya Honda
    Department of Pharmacology, Faculty of Medicine, Kyoto University, Kyoto 606 8501, Japan
    J Exp Med 203:325-35. 2006
    ..Our results show significant roles of both PGI2-IP and PGE2-EP2/EP4 signaling in the development of CIA, and suggest that inhibition of PGE2 synthesis alone may not be sufficient for suppression of RA symptoms...
  79. ncbi Insight into prostaglandin, leukotriene, and other eicosanoid functions using mice with targeted gene disruptions
    S C Austin
    Center for Experimental Therapeutics, Stellar Chance Labs, University of Pennsylvania, Philadelphia 19104, USA
    Prostaglandins Other Lipid Mediat 58:231-52. 1999
    ..g., receptors for various prostaglandins). This minireview will outline the phenotype of these knockout mice and what has been learned about eicosanoid functions through use of this novel methodology...
  80. ncbi Expression of cyclooxygenase isozymes during morphogenesis and cycling of pelage hair follicles in mouse skin: precocious onset of the first catagen phase and alopecia upon cyclooxygenase-2 overexpression
    Karin Muller-Decker
    Section of Eicosanoids and Epithelial Tumor Development, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    J Invest Dermatol 121:661-8. 2003
    ..Inhibition of transgenic COX-2 activity by feeding the specific COX-2 inhibitor valdecoxib suppressed the development of alopecia, indicating that COX-2-mediated prostaglandin synthesis is involved in hair follicle biology...
  81. ncbi Combined effects of prostaglandin E receptor subtype EP1 and subtype EP4 antagonists on intestinal tumorigenesis in adenomatous polyposis coli gene knockout mice
    Tomohiro Kitamura
    Cancer Prevention Basic Research Project, National Cancer Center Research Institute, Chuo Ku, Tokyo 104 0045, Japan
    Cancer Sci 94:618-21. 2003
    ..Our results indicate that EP(1) and EP(4) may have separate intrinsic roles and, to some extent, contribute to polyp formation independently. Thus, combination treatment has potential for the chemoprevention of colon carcinogenesis...
  82. ncbi Mapping of the genes encoding mouse prostaglandin D, E, and F and prostacyclin receptors
    T O Ishikawa
    Banyu Tsukuba Research Institute Merck, Japan
    Genomics 32:285-8. 1996
    ..Ptgdr mapped to proximal Chr 14, Ptgfr mapped to distal Chr 3, Ptgerepl mapped to middle Chr 8, and Ptgir mapped to proximal Chr 7...
  83. doi Prostaglandin F(2alpha) receptor signaling facilitates bleomycin-induced pulmonary fibrosis independently of transforming growth factor-beta
    Toru Oga
    Department of Pharmacology, Kyoto University Faculty of Medicine, Kyoto, Japan
    Nat Med 15:1426-30. 2009
    ..These findings show that PGF(2alpha)-FP signaling facilitates pulmonary fibrosis independently of TGF-beta and suggests this signaling pathway as a therapeutic target for IPF...
  84. ncbi Distinct cellular localization of mRNAs for three subtypes of prostaglandin E receptor in kidney
    Y Sugimoto
    Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Kyoto University, Japan
    Am J Physiol 266:F823-8. 1994
    ..The mRNA for EP1 subtype, which is coupled to Ca2+ mobilization, was specifically localized to the collecting ducts from the cortex ..
  85. ncbi Cloning and expression of cDNA for a mouse EP1 subtype of prostaglandin E receptor
    A Watabe
    Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Kyoto University, Japan
    J Biol Chem 268:20175-8. 1993
    A functional cDNA clone encoding a mouse EP1 subtype of prostaglandin (PG) E receptor was isolated from a mouse cDNA library by cross-hybridization with the mouse thromboxane A2 receptor cDNA...
  86. pmc Prostaglandin E receptor EP1 controls impulsive behavior under stress
    Yoko Matsuoka
    Department of Pharmacology, Kyoto University Faculty of Medicine, Kyoto 606 8501, Japan
    Proc Natl Acad Sci U S A 102:16066-71. 2005
    ..We now show that, under social or environmental stress, mice deficient in prostaglandin E receptor subtype EP1 (Ptger1(-/-)) manifest behavioral disinhibition, including impulsive aggression with defective social interaction, ..
  87. ncbi Impaired duodenal bicarbonate secretion and mucosal integrity in mice lacking prostaglandin E-receptor subtype EP(3)
    K Takeuchi
    Department of Pharmacology, Kyoto Pharmaceutical University, Yamashina, Kyoto, Japan
    Gastroenterology 117:1128-35. 1999
    ....

Research Grants2

  1. CXC CHEMOKINE REGULATION OF PROSTATE CANCER ANGIOGENESIS
    Bethany Moore; Fiscal Year: 2002
    ..These studies should lead to new insights into the biology of prostate cancer growth and metastasis, and pave the way to adapt adjuvant therapies for the treatment of this widespread disease. ..
  2. PGE2 Regulation of Epithelial/Fibroblast Interactions
    Bethany Moore; Fiscal Year: 2006
    ..abstract_text> ..