Genomes and Genes
Gene Symbol: Pten
Description: phosphatase and tensin homolog
Alias: 2310035O07Rik, A130070J02Rik, AI463227, B430203M17Rik, MMAC1, PTENbeta, TEP1, phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, mitochondrial PTENalpha, mutated in multiple advanced cancers 1
Publications197 found, 100 shown here
- Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesisZhenbang Chen
Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, Sloan Kettering Institute, 1275 York Avenue, New York, New York 10021, USA
Nature 436:725-30. 2005..The PTEN and p53 tumour suppressors are among the most commonly inactivated or mutated genes in human cancer including ..
- Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancersP A Steck
Department of Neuro Oncology, University of Texas, M D Anderson Cancer Center, Houston 77030, USA
Nat Genet 15:356-62. 1997..We have identified a gene, designated MMAC1, that spans these deletions and encodes a widely expressed 5.5-kb mRNA...
- Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cellsOmer H Yilmaz
Howard Hughes Medical Institute, Life Sciences Institute, Department of Internal Medicine, and Center for Stem Cell Biology, University of Michigan, Ann Arbor, Michigan 48109 2216, USA
Nature 441:475-82. 2006..Here we address this issue by conditionally deleting the Pten tumour suppressor gene in adult haematopoietic cells...
- Pten is essential for embryonic development and tumour suppressionA Di Cristofano
Department of Human Genetics, Memorial Sloan Kettering Cancer Center, Sloan Kettering Institute, New York, NY 10021, USA
Nat Genet 19:348-55. 1998The PTEN gene encodes a dual-specificity phosphatase mutated in a variety of human cancers...
- mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in miceDavid A Guertin
Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
Cancer Cell 15:148-59. 2009..Here, we show that transformed human prostate epithelial cells lacking PTEN require mTORC2 to form tumors when injected into nude mice...
- Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systemsK Podsypanina
Departments of Pathology and Medicine, College of Physicians and Surgeons, Columbia University, 630 W 168th Street, P and S 14 453, New York, NY 10032, USA
Proc Natl Acad Sci U S A 96:1563-8. 1999Pten/Mmac1+/- heterozygous mice exhibited neoplasms in multiple organs including the endometrium, liver, prostate, gastrointestinal tract, thyroid, and thymus...
- High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in miceA Suzuki
Amgen Institute Ontario Cancer Institute Department of Medical Biophysics and Immunology University of Toronto Toronto, Ontario, Canada M5G 2C1
Curr Biol 8:1169-78. 1998Germ-line and sporadic mutations in the tumor suppressor gene PTEN (also known as MMAC or TEP1), which encodes a dual-specificity phosphatase, cause a variety of cancers such as Cowden disease, glioblastoma, endometrial carcinoma and ..
- T cell-specific loss of Pten leads to defects in central and peripheral toleranceA Suzuki
Department of Molecular and Cellular Biology, Osaka University, 565 0871, Osaka, Japan
Immunity 14:523-34. 2001b>PTEN, a tumor suppressor gene, is essential for embryogenesis. We used the Cre-loxP system to generate a T cell-specific deletion of the Pten gene (Pten(flox/-) mice). All Pten(flox/-) mice develop CD4+ T cell lymphomas by 17 weeks...
- The deficiency of Akt1 is sufficient to suppress tumor development in Pten+/- miceMei Ling Chen
Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, Illinois 60607, USA
Genes Dev 20:1569-74. 2006The tumor suppressor PTEN is frequently inactivated in human cancers. A major downstream effector of PTEN is Akt, which is hyperactivated via PTEN inactivation...
- An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- miceK Podsypanina
Institute of Cancer Genetics, Department of Pathology and Medicine, College of Physicians and Surgeons, Columbia University, 1150 St Nicholas Avenue, Russ Berrie Pavilion, New York, NY 10032, USA
Proc Natl Acad Sci U S A 98:10320-5. 2001b>PTEN phosphatase acts as a tumor suppressor by negatively regulating the phosphoinositide 3-kinase (PI3K) signaling pathway. It is unclear which downstream components of this pathway are necessary for oncogenic transformation...
- Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytesChangchun Xiao
Immune Disease Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
Nat Immunol 9:405-14. 2008..The miR-17-92 miRNA suppressed expression of the tumor suppressor PTEN and the proapoptotic protein Bim...
- Lin-Sca-1+CD49fhigh stem/progenitors are tumor-initiating cells in the Pten-null prostate cancer modelDavid J Mulholland
Departments of Molecular and Medical Pharmacology, University of California at Los Angeles, Los Angeles, California 90095 1735, USA
Cancer Res 69:8555-62. 2009We have shown previously that Pten deletion leads to the expansion of subset of prostate cancer cells positive for CK5 and p63...
- p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiationHongwu Zheng
Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, USA
Nature 455:1129-33. 2008..The primary GBM subtype presents acutely as a high-grade disease that typically harbours mutations in EGFR, PTEN and INK4A/ARF (also known as CDKN2A), and the secondary GBM subtype evolves from the slow progression of a low-..
- Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity [corrected]Bangyan Stiles
Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095, USA
Proc Natl Acad Sci U S A 101:2082-7. 2004..Here, we investigated the function of phosphatase and tension homologue deleted on chromosome 10 (PTEN), a negative regulator of the phosphatidylinositol 3-kinase/AKT pathway, by targeted deletion of Pten in murine ..
- PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathwayH Sun
Department of Genetics, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
Proc Natl Acad Sci U S A 96:6199-204. 1999To investigate the molecular basis of PTEN-mediated tumor suppression, we introduced a null mutation into the mouse Pten gene by homologous recombination in embryonic stem (ES) cells...
- PTENless means moreBangyan Stiles
Department of Molecular and Medical Pharmacology, UCLA David Geffen School of Medicine, CHS23 234, Los Angeles, CA 90095, USA
Dev Biol 273:175-84. 2004..b>PTEN, a tumor suppressor that antagonizes the PI3 kinase pathway, is the newest one on the list...
- Inactivation of p53 and Pten promotes invasive bladder cancerAnna M Puzio-Kuter
Department of Urology, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
Genes Dev 23:675-80. 2009..We show that combined deletion of p53 and Pten in bladder epithelium leads to invasive cancer in a novel mouse model...
- High incidence of breast and endometrial neoplasia resembling human Cowden syndrome in pten+/- miceV Stambolic
Amgen Research Institute and Ontario Cancer Institute, Toronto, Canada
Cancer Res 60:3605-11. 2000b>PTEN is one of the most commonly mutated tumor suppressor genes in human cancer...
- PTEN is essential for cell migration but not for fate determination and tumourigenesis in the cerebellumSilvia Marino
Institute of Pathology, University Hospital, 8091 Zurich, Switzerland
Development 129:3513-22. 2002b>PTEN is a tumour suppressor gene involved in cell cycle control, apoptosis and mediation of adhesion and migration signalling. Germline mutations of PTEN in humans are associated with familial tumour syndromes, among them Cowden disease...
- Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos diseaseS A Backman
Department of Medical Biophysics, University of Toronto and Ontario Cancer Institute, 610 University Avenue, Toronto, Ontario M5G 2M9, Canada
Nat Genet 29:396-403. 2001Initially identified in high-grade gliomas, mutations in the PTEN tumor-suppressor are also found in many sporadic cancers and a few related autosomal dominant hamartoma syndromes...
- Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomasYasuo Horie
Department of Gastroenterology, Akita University School of Medicine, Akita, Japan
J Clin Invest 113:1774-83. 2004b>PTEN is a tumor suppressor gene mutated in many human cancers, and its expression is reduced or absent in almost half of hepatoma patients...
- Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathwayKevin Kyungsuk Park
F M Kirby Neurobiology Center, Children s Hospital, and Department of Neurology, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
Science 322:963-6. 2008..Deletion of PTEN (phosphatase and tensin homolog), a negative regulator of the mammalian target of rapamycin (mTOR) pathway, in ..
- Cell-autonomous activation of the PI3-kinase pathway initiates endometrial cancer from adult uterine epitheliumSanaz Memarzadeh
Department of Obstetrics and Gynecology, The David Geffen School of Medicine, Los Angeles, CA 90095, USA
Proc Natl Acad Sci U S A 107:17298-303. 2010..In the majority of these tumors, PTEN expression is lost in the epithelium but maintained in tumor stroma...
- Cell-specific conditional deletion of Pten in the uterus results in differential phenotypesTakiko Daikoku
Division of Reproductive Sciences, The Perinatal Institute, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
Gynecol Oncol 122:424-9. 2011..Our objective was to determine whether deletion of Pten specifically in the uterine stroma and myometrium induces cancer or manifests different phenotypes.
- Glioblastoma models reveal the connection between adult glial progenitors and the proneural phenotypeLiang Lei
Department of Pathology and Cell Biology, Columbia University, New York, New York, United States of America
PLoS ONE 6:e20041. 2011..In addition, it is unclear how different genetic alterations interact with cells of origin in determining tumor heterogeneity. This issue cannot be addressed by studying end-stage human tumors...
- Haploinsufficiency of the Pten tumor suppressor gene promotes prostate cancer progressionB Kwabi-Addo
Department of Pathology and Cell Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Proc Natl Acad Sci U S A 98:11563-8. 2001The PTEN gene encodes a lipid phosphatase that negatively regulates the phosphatidylinositol 3-kinase pathway and is inactivated in a wide variety of malignant neoplasms. High rates of loss of heterozygosity are observed at the 10q23...
- Cooperativity of Nkx3.1 and Pten loss of function in a mouse model of prostate carcinogenesisMinjung J Kim
Center for Advanced Biotechnology and Medicine and Department of Neuroscience, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
Proc Natl Acad Sci U S A 99:2884-9. 2002..Loss of function of Nkx3.1 in mice cooperates with loss of function of the Pten tumor suppressor gene in cancer progression...
- Genetic interactions between Pten and p53 in radiation-induced lymphoma developmentJian Hua Mao
Cancer Research Institute, University of California at San Francisco, 2340 Sutter Street, San Francisco, CA 94143, USA
Oncogene 22:8379-85. 2003..3 Mb interval that contained the Pten tumor suppressor gene...
- Dlg1-PTEN interaction regulates myelin thickness to prevent damaging peripheral nerve overmyelinationLaurent Cotter
Institute of Cell Biology, Department of Biology, Eidgenossische Technische Hochschule ETH Zurich, CH 8093 Zurich, Switzerland
Science 328:1415-8. 2010..Here, we show that, in Schwann cells, mammalian disks large homolog 1 (Dlg1) interacts with PTEN (phosphatase and tensin homolog deleted on chromosome 10) to inhibit axonal stimulation of myelination...
- Distinct roles for PTEN in prevention of T cell lymphoma and autoimmunity in miceXiaohe Liu
Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
J Clin Invest 120:2497-507. 2010Mutations in the tumor-suppressor gene phosphatase and tensin homolog deleted on chromosome 10 (Pten) are associated with multiple cancers in humans, including T cell malignancies...
- Recruited cells can become transformed and overtake PDGF-induced murine gliomas in vivo during tumor progressionElena I Fomchenko
Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America
PLoS ONE 6:e20605. 2011..Glioma progression is associated with elevated growth factor signaling and loss of function of tumor suppressors Ink4a, Arf and Pten. Yet, gliomas are cellularly heterogeneous; they recruit and trap normal cells during infiltration.
- β-Catenin activation synergizes with PTEN loss to cause bladder cancer formationI Ahmad
The Beatson Institute for Cancer Research, Glasgow, Scotland, UK
Oncogene 30:178-89. 2011..These lesions were characterized by a marked increase of the phosphatase and tensin homologue (PTEN) tumour suppressor protein...
- Cooperativity within and among Pten, p53, and Rb pathways induces high-grade astrocytoma in adult brainLionel M L Chow
Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
Cancer Cell 19:305-16. 2011Mutations in the PTEN, TP53, and RB1 pathways are obligate events in the pathogenesis of human glioblastomas...
- Impaired Fas response and autoimmunity in Pten+/- miceA Di Cristofano
Department of Human Genetics Molecular Biology Program, Memorial Sloan Kettering Cancer Center, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
Science 285:2122-5. 1999Inactivating mutations in the PTEN tumor suppressor gene, encoding a phosphatase, occur in three related human autosomal dominant disorders characterized by tumor susceptibility...
- Hypomorphic mutation of PDK1 suppresses tumorigenesis in PTEN(+/-) miceJose R Bayascas
MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom
Curr Biol 15:1839-46. 2005..The importance of this pathway in tumorigenesis has been highlighted by the finding that PTEN, the lipid phosphatase that breaks down PtdIns(3,4,5)P(3) to PtdIns(4,5)P(2), is frequently mutated in human cancer...
- Essential role for nuclear PTEN in maintaining chromosomal integrityWen Hong Shen
Department of Radiation Oncology, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA
Cell 128:157-70. 2007A broad spectrum of mutations in PTEN, encoding a lipid phosphatase that inactivates the P13-K/AKT pathway, is found associated with primary tumors...
- Phosphatase and tensin homolog, deleted on chromosome 10 deficiency in brain causes defects in synaptic structure, transmission and plasticity, and myelination abnormalitiesM M Fraser
Department of Developmental Neurobiology, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA
Neuroscience 151:476-88. 2008..The tumor-suppressor phosphatase with tensin homology (PTEN) is the central negative regulator of the PI3K pathway...
- Portrait of PTEN: messages from mutant miceAkira Suzuki
Division of Embryonic and Genetic Engineering, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812 8582, Japan
Cancer Sci 99:209-13. 2008b>PTEN is a tumor suppressor gene mutated in many human sporadic cancers and in hereditary cancer syndromes such as Cowden disease...
- Multi-genetic events collaboratively contribute to Pten-null leukaemia stem-cell formationWei Guo
Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, California 90095, USA
Nature 453:529-33. 2008..Here we show that Pten deletion in mouse haematopoietic stem cells leads to a myeloproliferative disorder, followed by acute T-..
- PTEN dosage is essential for neurofibroma development and malignant transformationCaroline Gregorian
Department of Molecular and Medical Pharmacology, Institute for Molecular Medicine, University of California, Los Angeles, CA 90095, USA
Proc Natl Acad Sci U S A 106:19479-84. 2009..In a series of genetically engineered murine models, we perturbed RAS/RAF/MAPK or/and PTEN/PI3K/AKT pathway, individually or simultaneously, via conditional activation of K-ras oncogene or deletion of Nf1 ..
- Somatic induction of Pten loss in a preclinical astrocytoma model reveals major roles in disease progression and avenues for target discovery and validationAndrew Xiao
Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Cancer Res 65:5172-80. 2005High-grade astrocytomas are invariably deadly and minimally responsive to therapy. Pten is frequently mutated in aggressive astrocytoma but not in low-grade astrocytoma. However, the Pten astrocytoma suppression mechanisms are unknown...
- PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entryMatthias Groszer
Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
Proc Natl Acad Sci U S A 103:111-6. 2006..Our previous study suggests that the phosphatase and tensin homologue deleted on chromosome 10 (PTEN) tumor suppressor gene, one of the most frequently mutated genes in glioblastomas, restricts neural stem/progenitor ..
- Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of PtenStephanie A Backman
Department of Medical Biophysics, University of Toronto, Ontario Cancer Institute and University Health Network, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9
Proc Natl Acad Sci U S A 101:1725-30. 2004b>PTEN is a tumor suppressor gene mutated in various advanced human neoplasias, including glioblastomas and prostate, breast, endometrial, and kidney cancers...
- Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-gamma and PTENMin Zhao
School of Medical Sciences and Department of Ophthalmology, University of Aberdeen, Aberdeen AB25 2ZD, UK
Nature 442:457-60. 2006..Deletion of the tumour suppressor phosphatase and tensin homolog (PTEN) enhances signalling and electrotactic responses...
- Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostateBrett S Carver
Cancer Biology and Genetics Program, Sloan Kettering Institute, New York, New York, USA
Nat Genet 41:619-24. 2009..specimens containing the TMPRSS2-ERG rearrangement are significantly enriched for loss of the tumor suppressor PTEN. In concordance with these findings, transgenic overexpression of ERG in mouse prostate tissue promotes marked ..
- A luminal epithelial stem cell that is a cell of origin for prostate cancerXi Wang
Department of Medicine, Herbert Irving Comprehensive Cancer Center, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
Nature 461:495-500. 2009..Furthermore, targeted deletion of the Pten tumour suppressor gene in CARNs results in rapid carcinoma formation after androgen-mediated regeneration...
- Pten in stromal fibroblasts suppresses mammary epithelial tumoursANTHONY J TRIMBOLI
Department of Molecular Genetics, College of Biological Sciences, The Ohio State University, Columbus, Ohio 43210, USA
Nature 461:1084-91. 2009..Here we show that the genetic inactivation of Pten in stromal fibroblasts of mouse mammary glands accelerated the initiation, progression and malignant transformation ..
- Insulin-like growth factor-II regulates PTEN expression in the mammary glandRoger A Moorehead
Ontario Cancer Institute University Health Network, University of Toronto, Toronto, Ontario M5G 2M9, Canada
J Biol Chem 278:50422-7. 2003The tumor suppressor PTEN is altered in many cancers, including breast cancer, but only a handful of factors are known to control its expression...
- Conditional Pten knock-out mice: a model for metastatic phaeochromocytomaEsther Korpershoek
Department of Pathology, Josephine Nefkens Institute, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
J Pathol 217:597-604. 2009..Here we describe adrenal tumours generated in a Pten conditional knock-out (KO) mouse model...
- Involvement of phosphoinositide 3-kinase and PTEN protein in mechanism of activation of TRPC6 protein in vascular smooth muscle cellsMichael Monet
Department of Pharmacology, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, Sherbrooke, Quebec J1H 5N4, Canada
J Biol Chem 287:17672-81. 2012..In this study we showed phosphoinositide 3-kinase and its antagonistic phosphatase, PTEN, are involved in the activation of TRPC6...
- PTEN and NF1 inactivation in Schwann cells produces a severe phenotype in the peripheral nervous system that promotes the development and malignant progression of peripheral nerve sheath tumorsVincent W Keng
Masonic Cancer Center, Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota 55455, USA
Cancer Res 72:3405-13. 2012..However, the phosphatase and tensin homolog (Pten) and neurofibromatosis 1 (Nf1) genes recently were found to be comutated in high-grade peripheral nerve sheath ..
- Pten loss causes hypertrophy and increased proliferation of astrocytes in vivoMelissa M Fraser
Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
Cancer Res 64:7773-9. 2004Somatic mutations of PTEN are found in many types of cancers including glioblastoma, the most malignant astrocytic tumor. PTEN mutation occurs in 25 to 40% of glioblastomas but is rarely observed in low-grade glial neoplasms...
- Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesityLeona Plum
Department of Mouse Genetics and Metabolism, Institute for Genetics, University of Cologne and Center of Molecular Medicine Cologne CMMC, Cologne, Germany
J Clin Invest 116:1886-901. 2006..signals in hypothalamic proopiomelanocortin (POMC) neurons by inactivating the gene for the PIP3 phosphatase Pten specifically in this cell type...
- Dysregulation of WNT/CTNNB1 and PI3K/AKT signaling in testicular stromal cells causes granulosa cell tumor of the testisAlexandre Boyer
Centre de Recherche en Reproduction Animale, Universite de Montreal, St Hyacinthe, Quebec J2S7C6, Canada
Carcinogenesis 30:869-78. 2009..if concomitant dysregulation of the WNT/CTNNB1 and PI3K/AKT pathways could synergize to cause testicular cancer, Pten(tm1Hwu/tm1Hwu);Ctnnb1(tm1Mmt/+);Amhr2(tm3(cre)Bhr/+) mice that express a dominant, stable CTNNB1 mutant and lack ..
- A limited role for PI(3,4,5)P3 regulation in controlling skeletal muscle mass in response to resistance exerciseD Lee Hamilton
Division of Molecular Physiology, University of Dundee, Dundee, Scotland, United Kingdom
PLoS ONE 5:e11624. 2010....
- Differentiation of the ductal epithelium and smooth muscle in the prostate gland are regulated by the Notch/PTEN-dependent mechanismXinyu Wu
Department of Urology, New York University School of Medicine, 423 East 23rd Street, New York, NY 10010, USA
Dev Biol 356:337-49. 2011..We found that gain of Notch function resulted in inhibition of the tumor suppressor PTEN, and increase in cell proliferation and progenitor cells in the basal epithelium and smooth muscle compartments...
- Localization of agonist-sensitive PtdIns(3,4,5)P3 reveals a nuclear pool that is insensitive to PTEN expressionYvonne Lindsay
Division of Molecular Physiology, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK
J Cell Sci 119:5160-8. 2006..A similar distribution of PtdIns(3,4,5)P3 was observed in U87MG cells, which lack the PtdIns(3,4,5)P3 phosphatase, PTEN. Re-expression of PTEN into U87MG cells ablated plasma membrane PtdIns(3,4,5)P3, but not the nuclear pool of this ..
- Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesisShidong Jia
Department of Cancer Biology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
Nature 454:776-9. 2008..Most strikingly, in an animal model of prostate tumour formation induced by Pten loss, ablation of p110beta (also known as Pik3cb), but not that of p110alpha (also known as Pik3ca), impeded ..
- eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progressionLuc Furic
Goodman Cancer Centre and Department of Biochemistry, Cancer Pavilion, McGill University, Montreal, QC, Canada H3A 1A3
Proc Natl Acad Sci U S A 107:14134-9. 2010..Our findings establish eIF4E phosphorylation as a critical event in tumorigenesis. These findings raise the possibility that chemical compounds that prevent the phosphorylation of eIF4E could act as anticancer drugs...
- T-cell lymphomas in T-cell-specific Pten-deficient mice originate in the thymusT J Hagenbeek
Department of Immunology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
Leukemia 22:608-19. 2008Phosphatase and tensin homolog deleted on chromosome 10 (Pten) is a tumor suppressor protein whose loss of lipid phosphatase activity is associated with lymphomagenesis...
- Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient miceXu Huang
MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
Biochem J 412:211-21. 2008..the importance of the LKB1-AMPK pathway in regulating tumorigenesis in mice resulting from deficiency of the PTEN (phosphatase and tensin homologue deleted on chromosome 10) tumour suppressor, which drives cell growth through ..
- Correlation between synaptogenesis and the PTEN phosphatase expression in dendrites during postnatal brain developmentClaudia Perandones
Fundacion Instituto Leloir, IIBBA CONICET, IIB FCEN UBA, Avenue Patricias Argentinas 435, Buenos Aires 1405, Argentina
Brain Res Mol Brain Res 128:8-19. 2004The PTEN (phosphatase and tensin homolog deleted on chromosome 10) tumor suppressor gene codifies a lipid inositol 3'-phosphatase that negatively regulates cell survival mediated by the phosphatidyl inositol 3' kinase (PIP3-kinase)--..
- Cell type-specific targeted mutations of Kras and Pten document proliferation arrest in granulosa cells versus oncogenic insult to ovarian surface epithelial cellsHeng Yu Fan
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
Cancer Res 69:6463-72. 2009..Conversely, levels of PTEN and phosphorylated p38 mitogen-activated protein kinase (MAPK) increased markedly in the mutant granulosa cells...
- The critical role of AKT2 in hepatic steatosis induced by PTEN lossLina He
Department of Molecular Pharmacology and Pharmaceutical Sciences, University of Southern California, Los Angeles, CA 90089, USA
Am J Pathol 176:2302-8. 2010..Deletion of the phosphatase Pten (phosphatase and tensin homologue deleted on chromosome 10) reduces PIP3 levels and leads to fatty liver ..
- Mammalian target of rapamycin-dependent acinar cell neoplasia after inactivation of Apc and Pten in the mouse salivary gland: implications for human acinic cell carcinomaCassandra R Diegel
Laboratory of Cell Signaling and Carcinogenesis, Van Andel Research Institute, Grand Rapids, Michigan 49504, USA
Cancer Res 70:9143-52. 2010..a mouse model in which both pathways are constitutively activated by the conditional inactivation of the Apc and Pten tumor suppressor genes. Loss of either Apc or Pten alone did not cause tumor development...
- Ubiquitination regulates PTEN nuclear import and tumor suppressionLloyd C Trotman
Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Cell 128:141-56. 2007The PTEN tumor suppressor is frequently affected in cancer cells, and inherited PTEN mutation causes cancer-susceptibility conditions such as Cowden syndrome...
- Pten controls lung morphogenesis, bronchioalveolar stem cells, and onset of lung adenocarcinomas in miceShigehisa Yanagi
Department of Molecular Biology, Akita University School of Medicine, Akita, Japan
J Clin Invest 117:2929-40. 2007b>PTEN is a tumor suppressor gene mutated in many human cancers...
- Epithelial Pten is dispensable for intestinal homeostasis but suppresses adenoma development and progression after Apc mutationVictoria Marsh
Cardiff School of Biosciences, Cardiff University, UK
Nat Genet 40:1436-44. 2008b>PTEN acts as a tumor suppressor in a range of tissue types and has been implicated in the regulation of intestinal stem cells...
- PTEN: a tumour suppressor that functions as a phospholipid phosphataseT Maehama
Dept of Biological Chemistry, University of Michigan, USA
Trends Cell Biol 9:125-8. 1999The tumour suppressor PTEN has been implicated in a large number of human tumours and is conserved from humans to worms...
- Keratinocyte-specific Pten deficiency results in epidermal hyperplasia, accelerated hair follicle morphogenesis and tumor formationAkira Suzuki
Department of Biochemistry, Akita University School of Medicine, Akita 010 8543, Japan
Cancer Res 63:674-81. 2003b>PTEN is a tumor suppressor gene mutated in many human cancers. We used the Cre-loxP system to generate a keratinocyte-specific null mutation of Pten in mice (k5Pten(flox/flox) mice)...
- Pten dose dictates cancer progression in the prostateLloyd C Trotman
Molecular Biology Program, Memorial Sloan Kettering Cancer Center, Sloan Kettering Institute, New York, New York, USA
PLoS Biol 1:E59. 2003Complete inactivation of the PTEN tumor suppressor gene is extremely common in advanced cancer, including prostate cancer (CaP). However, one PTEN allele is already lost in the vast majority of CaPs at presentation...
- The loss of PTEN allows TCR alphabeta lineage thymocytes to bypass IL-7 and Pre-TCR-mediated signalingThijs J Hagenbeek
Department of Immunology, Netherlands Cancer Institute, Amsterdam, The Netherlands
J Exp Med 200:883-94. 2004The phosphatase and tensin homologue deleted on chromosome 10 (PTEN) negatively regulates cell survival and proliferation mediated by phosphoinositol 3 kinases...
- Insulin hypersensitivity and resistance to streptozotocin-induced diabetes in mice lacking PTEN in adipose tissueChristine Kurlawalla-Martinez
Department of Pediatrics, Division of Neonatology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
Mol Cell Biol 25:2498-510. 2005..Phosphatase and a tensin homolog deleted from chromosome 10 (PTEN), a negative regulator of the phosphatidylinositol 3-kinase/AKT pathway, is hypothesized to inhibit the metabolic ..
- Targeted biallelic inactivation of Pten in the mouse prostate leads to prostate cancer accompanied by increased epithelial cell proliferation but not by reduced apoptosisXiaoqian Ma
Department of Pathology, Josephine Nefkens Institute, Erasmus Medical Center, Rotterdam, Netherlands
Cancer Res 65:5730-9. 2005The PTEN tumor suppressor gene is frequently inactivated in human tumors, including prostate cancer. Based on the Cre/loxP system, we generated a novel mouse prostate cancer model by targeted inactivation of the Pten gene...
- The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesisKoichi Hamada
Department of Molecular Biology, Department of Microbiology, Department of Gastroenterology, Akita University School of Medicine, Akita 010 8543, Japan
Genes Dev 19:2054-65. 2005b>PTEN is an important tumor suppressor gene. Hereditary mutation of PTEN causes tumor-susceptibility diseases such as Cowden disease...
- Pten deletion leads to the expansion of a prostatic stem/progenitor cell subpopulation and tumor initiationShunyou Wang
Departments of Molecular and Medical Pharmacology and Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine, University of California Los Angeles, 650 Charles E Young Drive South, Los Angeles, CA 90095, USA
Proc Natl Acad Sci U S A 103:1480-5. 2006b>PTEN (phosphatase and tensin homolog deleted on chromosome 10) is a potent tumor suppressor gene frequently mutated in human prostate cancers...
- Selective deletion of Pten in pancreatic beta cells leads to increased islet mass and resistance to STZ-induced diabetesBangyan L Stiles
Molecular and Medical Pharmacology, UCLA David Geffen School of Medicine, Los Angeles, California 90095, USA
Mol Cell Biol 26:2772-81. 2006Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) is a lipid phosphatase...
- Pten regulates neuronal arborization and social interaction in miceChang Hyuk Kwon
Kent Waldrep Foundation Center for Basic Neuroscience Research on Nerve Growth and Regeneration, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Neuron 50:377-88. 2006CNS deletion of Pten in the mouse has revealed its roles in controlling cell size and number, thus providing compelling etiology for macrocephaly and Lhermitte-Duclos disease...
- A novel leptin signalling pathway via PTEN inhibition in hypothalamic cell lines and pancreatic beta-cellsKe Ning
Neurosciences Institute, Division of Pathology and Neuroscience, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK
EMBO J 25:2377-87. 2006..of both hormones require intracellular signalling via the PI3-kinase pathway, which is inhibited by the phosphatase PTEN. We show that leptin-stimulated F-actin depolymerization in mouse hypothalamic cells is inhibited by PTEN, a ..
- Lifelong accumulation of bone in mice lacking Pten in osteoblastsXimeng Liu
Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Proc Natl Acad Sci U S A 104:2259-64. 2007..This process is negatively regulated by the Pten phosphatase, which inhibits the activity of PI3K...
- Oocyte-specific deletion of Pten causes premature activation of the primordial follicle poolPradeep Reddy
Department of Medical Biochemistry and Biophysics, Umea University, SE 901 87 Umea, Sweden
Science 319:611-3. 2008..We provide genetic evidence that in mice lacking PTEN (phosphatase and tensin homolog deleted on chromosome 10) in oocytes, a major negative regulator of ..
- Txnip balances metabolic and growth signaling via PTEN disulfide reductionSimon T Y Hui
Department of Biology, The Molecular Biology and Heart Institutes, The BioSciences Center, San Diego State University, 5500 Campanile Drive, San Diego, CA 92182, USA
Proc Natl Acad Sci U S A 105:3921-6. 2008..and hearts was associated with impaired mitochondrial fuel oxidation and the accumulation of oxidized (inactive) PTEN, whose activity depends on reduction of two critical cysteine residues...
- Pten haploinsufficiency accelerates formation of high-grade astrocytomasChang Hyuk Kwon
Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9133, USA
Cancer Res 68:3286-94. 2008..achieve high grade, they are frequently accompanied by Akt activation, reminiscent of the frequent association of PTEN mutations in human high-grade glioma...
- PTEN deletion and concomitant c-Myc activation do not lead to tumor formation in pancreatic beta cellsAnna Radziszewska
Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
J Biol Chem 284:2917-22. 2009Phosphatase and tensin homologue (PTEN) deleted on chromosome 10 is a dual-specific phosphatase and a potent antagonist of the phosphoinositide 3-kinase signaling pathway...
- Interactions between cells with distinct mutations in c-MYC and Pten in prostate cancerJongchan Kim
Department of Pathology, Vanderbilt University Medical Center, Nashville, TN, USA
PLoS Genet 5:e1000542. 2009..Focal c-MYC expression resulted in mild pathology, but prostate-specific deletion of a single allele of the Pten tumor suppressor gene cooperated with c-MYC to induce high grade prostatic intraepithelial neoplasia (HGPIN)/cancer ..
- Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTENV Stambolic
Amgen Institute, and Department of Medical Biophysics, University of Toronto, Ontario, Canada
Cell 95:29-39. 1998b>PTEN is a tumor suppressor with sequence homology to protein tyrosine phosphatases and the cytoskeletal protein tensin. mPTEN-mutant mouse embryos display regions of increased proliferation...
- Pten and p27KIP1 cooperate in prostate cancer tumor suppression in the mouseA Di Cristofano
Department of Human Genetics, Memorial Sloan Kettering Cancer Center, Sloan Kettering Institute, New York, New York, USA
Nat Genet 27:222-4. 2001The genetic bases underlying prostate tumorigenesis are poorly understood. Inactivation of the tumor-suppressor gene PTEN and lack of p27(KIP1) expression have been detected in most advanced prostate cancers...
- Pten regulates neuronal soma size: a mouse model of Lhermitte-Duclos diseaseC H Kwon
Department of Developmental Neurobiology, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, Tennessee 38105, USA
Nat Genet 29:404-11. 2001Somatic inactivation of PTEN occurs in different human tumors including glioblastoma, endometrial carcinoma and prostate carcinoma...
- Cre/loxP-mediated inactivation of the murine Pten tumor suppressor geneRalf Lesche
Howard Hughes Medical Institute and Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, California 90095, USA
Genesis 32:148-9. 2002
- Protean PTEN: form and functionKristin A Waite
Human Cancer Genetics, Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, 420 West 12th Avenue, Columbus, OH 43210, USA
Am J Hum Genet 70:829-44. 2002Germline mutations distributed across the PTEN tumor-suppressor gene have been found to result in a wide spectrum of phenotypic features...
- DNA mismatch repair deficiency accelerates endometrial tumorigenesis in Pten heterozygous miceHong Wang
Department of Pathology, Weill Medical Collegeof Cornell University, New York
Am J Pathol 160:1481-6. 2002b>PTEN mutation and microsatellite instability are two of the most common genetic alterations in uterine endometrioid carcinoma...
- Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathwaysMichael A Crackower
IMBA, Institute for Molecular Biotechnology of the Austrian Academy of Sciences, c o Dr Bohr Gasse 7, A 1030, Vienna, Austria
Cell 110:737-49. 2002The PTEN/PI3K signaling pathway regulates a vast array of fundamental cellular responses...
- PTEN regulation of neural development and CNS stem cellsLi Li
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
J Cell Biochem 88:24-8. 2003..Such a phosphatase, phosphatase and tensin homologue deleted on chromosome 10 (PTEN), was cloned as a tumor suppressor for gliomas...
- Critical roles of Pten in B cell homeostasis and immunoglobulin class switch recombinationAkira Suzuki
Department of Molecular Cell Biology, Research Institute for Microbial Disease, Osaka University, Osaka 565 0871, Japan
J Exp Med 197:657-67. 2003b>Pten is a tumor suppressor gene mutated in human cancers. We used the Cre-loxP system to generate a B cell-specific mutation of Pten in mice (bPten(flox/flox)mice)...
- Conditional loss of PTEN leads to testicular teratoma and enhances embryonic germ cell productionTohru Kimura
Department of Molecular Cell Biology, Research Institute for Microbial Diseases, Osaka University, Osaka 565 0871, Japan
Development 130:1691-700. 2003The tumor suppressor gene PTEN, which is frequently mutated in human cancers, encodes a lipid phosphatase for phosphatidylinositol 3,4,5-triphosphate [PtdIns(3,4,5)P3] and antagonizes phosphatidylinositol 3 kinase...
- Nkx3.1; Pten mutant mice develop invasive prostate adenocarcinoma and lymph node metastasesCory Abate-Shen
Center for Advanced Biotechnology and Medicine, University of Medicine and Dentistry, New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
Cancer Res 63:3886-90. 2003..Here, we have investigated the malignant potential of the high-grade PIN lesions that form in Nkx3.1(+/-); Pten(+/-) compound mutant mice and demonstrate their neoplastic progression in a serial transplantation/tissue ..
- Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancerShunyou Wang
Howard Hughes Medical Institute, University of California Los Angeles School of Medicine, 90095, Los Angeles, CA, USA
Cancer Cell 4:209-21. 2003The murine Pten prostate cancer model described in this study recapitulates the disease progression seen in humans: initiation of prostate cancer with prostatic intraepithelial neoplasia (PIN), followed by progression to invasive ..
- grb2 heterozygosity rescues embryonic lethality but not tumorigenesis in pten+/- miceMegan Cully
Department of Medical Biophysics, University of Toronto, Ontario Cancer Institute, Princess Margaret Hospital, 610 University Avenue, Room 7 411, Toronto, ON, Canada M5G 2M9
Proc Natl Acad Sci U S A 101:15358-63. 2004b>PTEN is a tumor suppressor gene implicated in both sporadic cancers and inherited tumor-prone syndromes. Here we show that pten+/- mice display a partially penetrant embryonic lethality...
- PTEN deletion in Bergmann glia leads to premature differentiation and affects laminar organizationQing Yue
Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095, USA
Development 132:3281-91. 2005..We provide evidence that loss of PTEN in Bergmann glia leads to premature differentiation of this crucial cell population and subsequently to extensive ..
- Pten deficiency activates distinct downstream signaling pathways in a tissue-specific mannerLina I Yoo
Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
Cancer Res 66:1929-39. 2006b>PTEN deficiency predisposes to a subset of human cancers, but the mechanism that underlies such selectivity is unknown. We have generated a mouse line that conditionally deletes Pten in urogenital epithelium...
- Cooperation between FGF8b overexpression and PTEN deficiency in prostate tumorigenesisChen Zhong
Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
Cancer Res 66:2188-94. 2006..overexpression of a mitogenic polypeptide (fibroblast growth factor 8, isoform b or FGF8b) and loss of function of PTEN tumor suppressor] were recapitulated into a new combinatorial mouse model...
- Role of Integrins in Pulmonary FibrosisEric White; Fiscal Year: 2006..basement membrane invasive activity of fibrotic-lung fibroblasts results from a deficiency in intracellular PTEN activity...
- Androgen Receptor in Prostate Cancer and BoneChawnshang Chang; Fiscal Year: 2005..The success of this proposal will allow a better understanding of the role of androgen in the metastatic spread of prostate cancer to bone and the molecular mechanism of bone remodeling by prostate cancer cells. ..
- Bone matrix proteins in prostate cancer progressionPradip Roy Burman; Fiscal Year: 2010..abstract_text> ..
- Androgen Receptor in B Cell Development and FunctionsChawnshang Chang; Fiscal Year: 2010..abstract_text> ..
- Role of Acetaldehyde in Alcoholic CardiomyopathyJun Ren; Fiscal Year: 2008..Our long-term goal is to establish the toxic mechanism of acetaldehyde in the development of alcoholic cardiomyopathy so that prevention and treatment can be optimized [unreadable] [unreadable]..
- Suppression of Androgen Receptor by PTENChawnshang Chang; Fiscal Year: 2006unreadable] DESCRIPTION (provided by applicant): PTEN and AR are highly involved in the prostate cancer progression. The linkage between these two antagonistic factors remains unclear...
- Single and Double Knockout of TR2 and TR4 ReceptorsChawnshang Chang; Fiscal Year: 2006..In summary, this proposal provides us the first opportunity to study the potential in vivo physiological roles of the TR2 and TR4 orphan nuclear receptors. ..
- AR-ASSOCIATED PROTEINS IN PROSTATE CARCINOGENESISChawnshang Chang; Fiscal Year: 2001..As a result, ultimately, we might find a potential protocol to manage the progression of CaP in the clinic. ..
- Induction of AR Transactivation by DHT and E2Chawnshang Chang; Fiscal Year: 2004....
- TR4 ORPHAN RECEPTOR IN TESTISChawnshang Chang; Fiscal Year: 2004..Aim 5) Study cross talk between p53 and TR4 in testes. The successful completion of this proposal may help us to better understand the molecular mechanism of the TR4 and its potential biochemical functions. ..
- IGF-1, Oxidative Stress and Cardiovascular AgingJun Ren; Fiscal Year: 2002..Our long-term goal is to establish the causal link among IGF-1 deficiency, enhanced oxidative damage and ventricular dysfunction in the progression of cardiovascular aging so that hormonal or antioxidant therapy can be optimized...
- TR2 AND TR3 ORPHAN RECEPTORS IN PROSTATE CANCERChawnshang Chang; Fiscal Year: 2002..abstract_text> ..
- Validation of potential early diagnostic and prognostic markers for pancreatic caPaul Chiao; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Mechanisms of Tumorigenesis in Pancreatic Epithelial CellsPaul Chiao; Fiscal Year: 2009..abstract_text> ..
- THE ROLE OF RE1A IN HUMAN ADENOCARCINOMA OF PANCREASPaul Chiao; Fiscal Year: 2002..The studies may lead to the development of specific inhibitors of Rel/NFkB for use in novel therapies for pancreatic cancers. ..
- Fatty Acid Effects on COX-2 Dependent Prostate CancerRussell Klein; Fiscal Year: 2005..abstract_text> ..
- PGE2 Regulation of Epithelial/Fibroblast InteractionsBethany Moore; Fiscal Year: 2006..abstract_text> ..
- Fetal Lung Development:Role of Wnt5a SignalingChanggong Li; Fiscal Year: 2008..This information will be of utility in understanding the molecular mechanisms of congenital and induced lung disease. ..
- CXC CHEMOKINE REGULATION OF PROSTATE CANCER ANGIOGENESISBethany Moore; Fiscal Year: 2002..These studies should lead to new insights into the biology of prostate cancer growth and metastasis, and pave the way to adapt adjuvant therapies for the treatment of this widespread disease. ..