Ptafr

Summary

Gene Symbol: Ptafr
Description: platelet-activating factor receptor
Alias: PAFR, platelet-activating factor receptor, PAF receptor
Species: mouse
Products:     Ptafr

Top Publications

  1. Stojanov T, O NEILL C. Ontogeny of expression of a receptor for platelet-activating factor in mouse preimplantation embryos and the effects of fertilization and culture in vitro on its expression. Biol Reprod. 1999;60:674-82 pubmed
    ..Transcripts for the G protein-linked PAF receptor were detected in the late 2-cell-stage embryo and in all stages from the 4-cell stage to blastocysts...
  2. Akilesh S, Dudley M, Eden P, Roopenian D. Efficient chromosomal mapping of a methylcholanthrene-induced tumor antigen by CTL immunoselection. J Immunol. 2001;167:5143-9 pubmed
    ..1 cM interval on chromosome 4. This region of the mouse genome is rich in tumor-modifier genes and this positioning of Ram1 may thus provide insight into the genetic basis of 3-methycholanthrene-induced tumor Ags. ..
  3. Walterscheid J, Ullrich S, Nghiem D. Platelet-activating factor, a molecular sensor for cellular damage, activates systemic immune suppression. J Exp Med. 2002;195:171-9 pubmed
    ..Furthermore, immune suppression was blocked when UV-irradiated mice were injected with PAF receptor antagonists...
  4. Branger J, Wieland C, Florquin S, Maris N, Pater J, Speelman P, et al. Platelet-activating factor receptor-deficient mice show an unaltered clearance of nontypeable Haemophilus influenzae from their respiratory tract. Shock. 2004;22:543-7 pubmed
    ..a glycerophospholipid with proinflammatory properties, exerts its biological effects by interacting with the PAF receptor (PAFR) expressed on many different cell types...
  5. Kihara Y, Ishii S, Kita Y, Toda A, Shimada A, Shimizu T. Dual phase regulation of experimental allergic encephalomyelitis by platelet-activating factor. J Exp Med. 2005;202:853-63 pubmed
    ..To investigate the role of platelet-activating factor (PAF) in this disease, PAF receptor (PAFR) KO (PAFR-KO) and wild-type (WT) mice, on a C57BL/6 genetic background, were immunized with myelin ..
  6. Sahu R, Kozman A, Yao Y, Dasilva S, Rezania S, Martel K, et al. Loss of the platelet activating factor receptor in mice augments PMA-induced inflammation and cutaneous chemical carcinogenesis. Carcinogenesis. 2012;33:694-701 pubmed publisher
    ..This suggests that the platelet activating factor receptor (PAFR) acts to suppress chronic inflammation in response to other stimuli, such as barrier ..
  7. Ishii S, Shimizu T. Platelet-activating factor (PAF) receptor and genetically engineered PAF receptor mutant mice. Prog Lipid Res. 2000;39:41-82 pubmed
    ..PAF acts by binding to a unique G-protein-coupled seven transmembrane receptor. PAF receptor is linked to intracellular signal transduction pathways, including turnover of phosphatidylinositol, elevation ..
  8. Dyer K, Percopo C, Xie Z, Yang Z, Kim J, Davoine F, et al. Mouse and human eosinophils degranulate in response to platelet-activating factor (PAF) and lysoPAF via a PAF-receptor-independent mechanism: evidence for a novel receptor. J Immunol. 2010;184:6327-34 pubmed publisher
    ..promote degranulation (release of eosinophil peroxidase) via a mechanism that is independent of the characterized PAFR. Specifically, we demonstrate that receptor antagonists CV-3988 and WEB-2086 and pertussis toxin have no impact on ..
  9. Hikiji H, Ishii S, Shindou H, Takato T, Shimizu T. Absence of platelet-activating factor receptor protects mice from osteoporosis following ovariectomy. J Clin Invest. 2004;114:85-93 pubmed
    ..Using PAF receptor-deficient mice, we evaluated the role of PAF in the development of bone resorption following ovariectomy, a ..

More Information

Publications80

  1. Ishii S, Nagase T, Shindou H, Takizawa H, Ouchi Y, Shimizu T. Platelet-activating factor receptor develops airway hyperresponsiveness independently of airway inflammation in a murine asthma model. J Immunol. 2004;172:7095-102 pubmed
    ..We show in this study that mice deficient in PAF receptor exhibited significantly reduced airway hyperresponsiveness to muscarinic cholinergic stimulation in an asthma ..
  2. Sreevidya C, Khaskhely N, Fukunaga A, Khaskina P, Ullrich S. Inhibition of photocarcinogenesis by platelet-activating factor or serotonin receptor antagonists. Cancer Res. 2008;68:3978-84 pubmed publisher
  3. Tsuda M, Ishii S, Masuda T, Hasegawa S, Nakamura K, Nagata K, et al. Reduced pain behaviors and extracellular signal-related protein kinase activation in primary sensory neurons by peripheral tissue injury in mice lacking platelet-activating factor receptor. J Neurochem. 2007;102:1658-1668 pubmed publisher
    ..the role of platelet-activating factor (PAF), a phospholipid mediator, in pain signaling using mice lacking PAF receptor (pafr-/- mice)...
  4. Marathe G, Johnson C, Billings S, Southall M, Pei Y, Spandau D, et al. Ultraviolet B radiation generates platelet-activating factor-like phospholipids underlying cutaneous damage. J Biol Chem. 2005;280:35448-57 pubmed
    ..Expression of the PAF receptor in the PAF receptor-negative epidermoid cell line KB augmented apoptosis in response to UVB irradiation...
  5. Zhang Q, Mousdicas N, Yi Q, Al Hassani M, Billings S, Perkins S, et al. Staphylococcal lipoteichoic acid inhibits delayed-type hypersensitivity reactions via the platelet-activating factor receptor. J Clin Invest. 2005;115:2855-61 pubmed
    ..These findings show a novel mechanism by which staphylococcal infections can inhibit Th1 reactions and thus worsen Th2 skin diseases, such as atopic dermatitis. ..
  6. Radin J, Orihuela C, Murti G, Guglielmo C, Murray P, Tuomanen E. beta-Arrestin 1 participates in platelet-activating factor receptor-mediated endocytosis of Streptococcus pneumoniae. Infect Immun. 2005;73:7827-35 pubmed
    ..The platelet-activating factor receptor (PAFr) has been suggested as a portal of entry...
  7. Rijneveld A, Weijer S, Florquin S, Speelman P, Shimizu T, Ishii S, et al. Improved host defense against pneumococcal pneumonia in platelet-activating factor receptor-deficient mice. J Infect Dis. 2004;189:711-6 pubmed
    ..factor (PAF) is a phospholipid with proinflammatory properties that binds to a specific receptor (PAF receptor [PAFR]) that is expressed on many different cell types...
  8. Souza D, Pinho V, Soares A, Shimizu T, Ishii S, Teixeira M. Role of PAF receptors during intestinal ischemia and reperfusion injury. A comparative study between PAF receptor-deficient mice and PAF receptor antagonist treatment. Br J Pharmacol. 2003;139:733-40 pubmed
    ..The present study aimed to confirm a role for platelet-activating factor receptor(s) (PAFR) during ischemia and reperfusion injury by using genetically modified mice deficient in the PAFR (PAFR(-/-) mice) ..
  9. Yao Y, Wolverton J, Zhang Q, Marathe G, Al Hassani M, Konger R, et al. Ultraviolet B radiation generated platelet-activating factor receptor agonist formation involves EGF-R-mediated reactive oxygen species. J Immunol. 2009;182:2842-8 pubmed publisher
    ..These studies suggest that UVB-induced systemic immunosuppression is due to epidermal growth factor receptor-mediated ROS which results in PAF-R agonist formation. ..
  10. Ishii S, Kuwaki T, Nagase T, Maki K, Tashiro F, Sunaga S, et al. Impaired anaphylactic responses with intact sensitivity to endotoxin in mice lacking a platelet-activating factor receptor. J Exp Med. 1998;187:1779-88 pubmed
    ..Here we show that disruption of the PAF receptor gene in mice caused a marked reduction in systemic anaphylactic symptoms...
  11. Sahu R, Petrache I, Van Demark M, Rashid B, Ocana J, Tang Y, et al. Cigarette smoke exposure inhibits contact hypersensitivity via the generation of platelet-activating factor agonists. J Immunol. 2013;190:2447-54 pubmed publisher
    ..These studies provide the first evidence, to our knowledge, that the pro-oxidative stressor CS can modulate cutaneous immunity via the generation of PAF-R agonists produced through lipid oxidation. ..
  12. Ishii S, Matsuda Y, Nakamura M, Waga I, Kume K, Izumi T, et al. A murine platelet-activating factor receptor gene: cloning, chromosomal localization and up-regulation of expression by lipopolysaccharide in peritoneal resident macrophages. Biochem J. 1996;314 ( Pt 2):671-8 pubmed
    A murine gene encoding a platelet-activating factor receptor (PAFR) was cloned. The gene was mapped to a region of the D2.2 band of chromosome 4 both by fluorescence in situ hybridization and by molecular linkage analysis...
  13. Ishii S, Nagase T, Tashiro F, Ikuta K, Sato S, Waga I, et al. Bronchial hyperreactivity, increased endotoxin lethality and melanocytic tumorigenesis in transgenic mice overexpressing platelet-activating factor receptor. EMBO J. 1997;16:133-42 pubmed
    ..To answer this question, we established transgenic mice over-expressing a guinea-pig PAF receptor (PAFR)...
  14. Fillon S, Soulis K, Rajasekaran S, Benedict Hamilton H, Radin J, Orihuela C, et al. Platelet-activating factor receptor and innate immunity: uptake of gram-positive bacterial cell wall into host cells and cell-specific pathophysiology. J Immunol. 2006;177:6182-91 pubmed
    ..We describe an additional recognition system mediated by the platelet-activating factor receptor (PAFr) and directed to the pathogen-associated molecular pattern phosphorylcholine that results in the uptake of ..
  15. McCullers J, Iverson A, McKeon R, Murray P. The platelet activating factor receptor is not required for exacerbation of bacterial pneumonia following influenza. Scand J Infect Dis. 2008;40:11-7 pubmed
    ..advanced the hypothesis that interactions of pneumococcus with the receptor for platelet activating factor (PAFR) in the lung were facilitated by antecedent influenza virus infection and play a major role in the pathogenesis of ..
  16. Doi K, Okamoto K, Negishi K, Suzuki Y, Nakao A, Fujita T, et al. Attenuation of folic acid-induced renal inflammatory injury in platelet-activating factor receptor-deficient mice. Am J Pathol. 2006;168:1413-24 pubmed
    ..In this study we used platelet-activating factor receptor (PAFR)-deficient mice to elucidate the role of PAF in inflammatory renal injury induced by folic acid administration...
  17. Tyrer P, Foxwell A, Cripps A, Apicella M, Kyd J. Microbial pattern recognition receptors mediate M-cell uptake of a gram-negative bacterium. Infect Immun. 2006;74:625-31 pubmed
    ..Taken together, the data suggest that pathogen-associated molecular pattern interactions with pattern recognition receptors are key factors in M-cell recognition of intestinal antigens for mucosal immune priming. ..
  18. Zhang Q, Yao Y, Konger R, Sinn A, Cai S, Pollok K, et al. UVB radiation-mediated inhibition of contact hypersensitivity reactions is dependent on the platelet-activating factor system. J Invest Dermatol. 2008;128:1780-7 pubmed publisher
    ..These studies suggest that UVB irradiation results in epidermal production of PAF agonists, which then act on PAF-R-positive bone marrow-derived cells to upregulate IL-10 through COX-2-generated prostaglandins. ..
  19. Han S, Kim J, Seo H, Martin M, Chung G, Michalek S, et al. Lipoteichoic acid-induced nitric oxide production depends on the activation of platelet-activating factor receptor and Jak2. J Immunol. 2006;176:573-9 pubmed
    ..Inhibitors of platelet-activating factor receptor (PAFR) blocked LTA- or Pam3CSK4-induced production of NO but not TNF-alpha...
  20. Souza D, Fagundes C, Sousa L, Amaral F, Souza R, Souza A, et al. Essential role of platelet-activating factor receptor in the pathogenesis of Dengue virus infection. Proc Natl Acad Sci U S A. 2009;106:14138-43 pubmed publisher
    ..Treatment is supportive. Activation of platelet-activating factor (PAF) receptor (PAFR) on endothelial cells and leukocytes induces increase in vascular permeability, hypotension, and production of ..
  21. Sahu R, Turner M, Dasilva S, Rashid B, Ocana J, Perkins S, et al. The environmental stressor ultraviolet B radiation inhibits murine antitumor immunity through its ability to generate platelet-activating factor agonists. Carcinogenesis. 2012;33:1360-7 pubmed publisher
    ..in wild-type (WT) mice, independent of whether B16F10 cells express PAF-Rs, but do not augment tumor growth in Pafr -/- mice...
  22. Van Der Sluijs K, Van Elden L, Nijhuis M, Schuurman R, Florquin S, Shimizu T, et al. Involvement of the platelet-activating factor receptor in host defense against Streptococcus pneumoniae during postinfluenza pneumonia. Am J Physiol Lung Cell Mol Physiol. 2006;290:L194-9 pubmed
    ..Considering that S. pneumoniae utilizes the platelet-activating factor receptor (PAFR) to invade the respiratory epithelium and that the PAFR is upregulated during viral infection, we here used PAFR ..
  23. Sahu R, Rezania S, Ocana J, DaSilva Arnold S, Bradish J, Richey J, et al. Topical application of a platelet activating factor receptor agonist suppresses phorbol ester-induced acute and chronic inflammation and has cancer chemopreventive activity in mouse skin. PLoS ONE. 2014;9:e111608 pubmed publisher
    ..PAF acts by binding to a specific G-protein coupled receptor (PAF-R, Ptafr). However, the role of chronic PAF-R activation on sustained inflammatory responses has been largely ignored...
  24. Row B, Kheirandish L, Li R, Guo S, Brittian K, Hardy M, et al. Platelet-activating factor receptor-deficient mice are protected from experimental sleep apnea-induced learning deficits. J Neurochem. 2004;89:189-96 pubmed
    ..We report that mice deficient in the cell surface receptor for PAF (PAFR-/-), a bioactive mediator of oxidative stress and inflammation, are protected from the spatial reference learning ..
  25. Matsumura Y, Byrne S, Nghiem D, Miyahara Y, Ullrich S. A role for inflammatory mediators in the induction of immunoregulatory B cells. J Immunol. 2006;177:4810-7 pubmed
    ..When UV-irradiated mice were injected with PCA 4248, a selective PAF receptor (PAFR) antagonist, transfer of tolerance was suppressed...
  26. Menezes Garcia Z, Oliveira M, Lima R, Soriani F, Cisalpino D, Botion L, et al. Lack of platelet-activating factor receptor protects mice against diet-induced adipose inflammation and insulin-resistance despite fat pad expansion. Obesity (Silver Spring). 2014;22:663-72 pubmed publisher
    ..The effects of diet-induced metabolic and inflammatory dysfunction in mice with deletion of the PAF receptor (PAFR(-/-) ) were evaluated in this study...
  27. Wu C, Stojanov T, Chami O, Ishii S, Shimizu T, Li A, et al. Evidence for the autocrine induction of capacitation of mammalian spermatozoa. J Biol Chem. 2001;276:26962-8 pubmed
    ..These actions were inhibited by a PAF receptor antagonist (UR-12519) and by extracellular recombinant PAF:acetylhydrolase (an enzyme that degrades PAF to a ..
  28. Kim B, Shin E, Kim H, Chung Y, Dang D, Jung B, et al. Platelet-activating factor receptor knockout mice are protected from MPTP-induced dopaminergic degeneration. Neurochem Int. 2013;63:121-32 pubmed publisher
    ..We propose for the first time that PAF/PAF-R can mediate dopaminergic degeneration via an NF-?B-dependent signaling process. ..
  29. Koga M, Bizzarro B, Sa Nunes A, Rios F, Jancar S. Activation of PAF-receptor induces regulatory dendritic cells through PGE2 and IL-10. Prostaglandins Leukot Essent Fatty Acids. 2013;89:319-26 pubmed publisher
    Activation of the platelet-activating factor receptor (PAFR) in macrophages is associated with suppressor phenotype. Here, we investigated the PAFR in murine dendritic cells (DC)...
  30. Ohshima N, Ishii S, Izumi T, Shimizu T. Receptor-dependent metabolism of platelet-activating factor in murine macrophages. J Biol Chem. 2002;277:9722-7 pubmed
    Degradation of platelet-activating factor (PAF) was examined by incubating PAF with macrophages from PAF receptor-deficient mice. The degradation rate was halved as compared with wild-type mice...
  31. Tanaka Y, Nagai Y, Kuroishi T, Endo Y, Sugawara S. Stimulation of Ly-6G on neutrophils in LPS-primed mice induces platelet-activating factor (PAF)-mediated anaphylaxis-like shock. J Leukoc Biol. 2012;91:485-94 pubmed publisher
    ..These findings may be related to adult respiratory distress syndrome, although the natural ligand for Ly-6G remains to be identified. ..
  32. Chacón Salinas R, Chen L, Chávez Blanco A, Limon Flores A, Ma Y, Ullrich S. An essential role for platelet-activating factor in activating mast cell migration following ultraviolet irradiation. J Leukoc Biol. 2014;95:139-48 pubmed publisher
    ..However, when mast cells from PAFR-/- mice were used, the reconstituted mice were not susceptible to the suppressive effects of UV...
  33. Lee J, Simborio H, Reyes A, Hop H, Arayan L, Lee H, et al. Influence of platelet-activating factor receptor (PAFR) on Brucella abortus infection: implications for manipulating the phagocytic strategy of B. abortus. BMC Microbiol. 2016;16:70 pubmed publisher
    ..abortus. Accordingly, we demonstrated that platelet-activating factor receptor (PAFR) affects host cell response against B. abortus infection. First of all, B...
  34. Bachi A, Dos Santos L, Nonogaki S, Jancar S, Jasiulionis M. Apoptotic cells contribute to melanoma progression and this effect is partially mediated by the platelet-activating factor receptor. Mediators Inflamm. 2012;2012:610371 pubmed publisher
    There is evidence that the platelet-activating factor receptor (PAFR) is involved in the clearance of apoptotic cells by macrophages, and that this is associated with anti-inflammatory phenotype...
  35. Keely S, Glover L, Weissmueller T, MacManus C, Fillon S, Fennimore B, et al. Hypoxia-inducible factor-dependent regulation of platelet-activating factor receptor as a route for gram-positive bacterial translocation across epithelia. Mol Biol Cell. 2010;21:538-46 pubmed publisher
    ..A screen of relevant pathway inhibitors identified a prominent role for the platelet-activating factor receptor (PAFr) in hypoxia-associated bacterial translocation, wherein pharmacologic antagonists of PAFr blocked bacterial ..
  36. Hudry Clergeon H, Stengel D, Ninio E, Vilgrain I. Platelet-activating factor increases VE-cadherin tyrosine phosphorylation in mouse endothelial cells and its association with the PtdIns3'-kinase. FASEB J. 2005;19:512-20 pubmed
    ..This study was designed to characterize PAF receptor (PAF-R) expression and its specific contribution to the modifications of adherens junctions in mouse ..
  37. Zhang Q, Sitzman L, Al Hassani M, Cai S, Pollok K, Travers J, et al. Involvement of platelet-activating factor in ultraviolet B-induced hyperalgesia. J Invest Dermatol. 2009;129:167-74 pubmed publisher
    ..These substances exert effects through the PAF receptor (PAF-R). This study was designed to assess whether PAF-R is involved in UVB-induced hyperalgesia...
  38. Ferracini M, Rios F, Pecenin M, Jancar S. Clearance of apoptotic cells by macrophages induces regulatory phenotype and involves stimulation of CD36 and platelet-activating factor receptor. Mediators Inflamm. 2013;2013:950273 pubmed publisher
    ..in the recognition of apoptotic cells (AC), and we have shown that the platelet-activating factor receptor (PAFR) is also involved...
  39. Nagase T, Ishii S, Kume K, Uozumi N, Izumi T, Ouchi Y, et al. Platelet-activating factor mediates acid-induced lung injury in genetically engineered mice. J Clin Invest. 1999;104:1071-6 pubmed
    ..Here, we investigated the role of platelet-activating factor (PAF) and the PAF receptor (PAFR) gene in a murine model of acid aspiration-induced lung injury...
  40. de Oliveira M, Menezes Garcia Z, Arifa R, de Paula T, Andrade J, Santos S, et al. Platelet-activating factor modulates fat storage in the liver induced by a high-refined carbohydrate-containing diet. J Nutr Biochem. 2015;26:978-85 pubmed publisher
    ..Wild-type (WT) and PAF receptor-deficient (PAFR(-/-)) mice were fed the same diets for 8 weeks...
  41. Wang E, Han Y, Jia X. PAFR-deficiency alleviates myocardial ischemia/reperfusion injury in mice via suppressing inflammation, oxidative stress and apoptosis. Biochem Biophys Res Commun. 2018;495:2475-2481 pubmed publisher
    ..PAF acts on a single receptor (PAFR), which is expressed on cellular and nuclear membranes of various cell types...
  42. Travers J, Edenberg H, Zhang Q, Al Hassani M, Yi Q, Baskaran S, et al. Augmentation of UVB radiation-mediated early gene expression by the epidermal platelet-activating factor receptor. J Invest Dermatol. 2008;128:455-60 pubmed
    ..To gain a better insight into the role of the epidermal PAF receptor (PAF-R) in UVB-mediated gene expression, Affymetrix oligonucleotide microarrays were used to compare mRNA ..
  43. Angeli V, Llodra J, Rong J, Satoh K, Ishii S, Shimizu T, et al. Dyslipidemia associated with atherosclerotic disease systemically alters dendritic cell mobilization. Immunity. 2004;21:561-74 pubmed
    ..In this context, HDL and PAFAH maintain a normally functional DC compartment. ..
  44. Roudebush W, Purnell E, Stoddart N, Fleming S. Embryonic platelet-activating factor: temporal expression of the ligand and receptor. J Assist Reprod Genet. 2002;19:72-8 pubmed
    ..The data provide a clue to the complicated cell signaling system involving PAF production and receptor expression that may help our understanding of developmental events. ..
  45. Voorhees T, Chang J, Yao Y, Kaplan M, Chang C, Travers J. Dendritic cells produce inflammatory cytokines in response to bacterial products from Staphylococcus aureus-infected atopic dermatitis lesions. Cell Immunol. 2011;267:17-22 pubmed publisher
    ..Thus, our results support a role for DC in the worsening of AD inflammation due to secondary bacteria infections. ..
  46. Leary P, Rajasekaran S, Morrison R, Tuomanen E, Chin T, Hofmann P. A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation. Am J Physiol Heart Circ Physiol. 2008;294:H2775-84 pubmed publisher
    ..To determine whether endogenous activation of the PAF receptor is cardioprotective, we examined postischemic functional recovery in isolated hearts from wild-type and PAF ..
  47. Talvani A, Santana G, Barcelos L, Ishii S, Shimizu T, Romanha A, et al. Experimental Trypanosoma cruzi infection in platelet-activating factor receptor-deficient mice. Microbes Infect. 2003;5:789-96 pubmed
    ..cruzi infection by using mice that were genetically deficient in the PAF receptor. We observed that infected hearts of PAFR(-/-) mice had an increased number of parasite nests, associated with ..
  48. Ferracini M, Sahu R, Harrison K, Waeiss R, Murphy R, Jancar S, et al. Topical photodynamic therapy induces systemic immunosuppression via generation of platelet-activating factor receptor ligands. J Invest Dermatol. 2015;135:321-323 pubmed publisher
  49. Nagase T, Uozumi N, Ishii S, Kita Y, Yamamoto H, Ohga E, et al. A pivotal role of cytosolic phospholipase A(2) in bleomycin-induced pulmonary fibrosis. Nat Med. 2002;8:480-4 pubmed
    ..The inhibition of cPLA(2)-initiated pathways might provide a novel therapeutic approach to pulmonary fibrosis, for which no pharmaceutical agents are currently available. ..
  50. Sugatani J, Sadamitsu S, Yamaguchi M, Yamazaki Y, Higa R, Hattori Y, et al. Antiobese function of platelet-activating factor: increased adiposity in platelet-activating factor receptor-deficient mice with age. FASEB J. 2014;28:440-52 pubmed publisher
    ..factor (PAF) acetyltransferase, which is involved in PAF biosynthesis, and the PAF receptor were predominantly localized in BAT macrophages, whereas brown adipocytes possessed the enzyme and functional ..
  51. Ryan S, Harris C, Carswell C, Baenziger J, Bennett S. Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons. J Lipid Res. 2008;49:2250-8 pubmed publisher
    ..We find that both C16-PAF and C18-PAF cause PAF receptor-independent death but signal through different pathways...
  52. de Oliveira S, Andrade L, Onuchic A, Nonogaki S, Fernandes P, Pinheiro M, et al. Platelet-activating factor receptor (PAF-R)-dependent pathways control tumour growth and tumour response to chemotherapy. BMC Cancer. 2010;10:200 pubmed publisher
    ..Combination therapy with a PAF-R antagonist and a chemotherapeutic drug may represent a new and promising strategy for the treatment of some tumours. ..
  53. Wang Y, Gao Z, Zhang Y, Feng S, Liu Y, Shields L, et al. Attenuated Reactive Gliosis and Enhanced Functional Recovery Following Spinal Cord Injury in Null Mutant Mice of Platelet-Activating Factor Receptor. Mol Neurobiol. 2016;53:3448-3461 pubmed publisher
    ..Excessive PAF plays an important role in neural injury via its specific receptor (PAFR)...
  54. Roudebush W, LaMarche M, Levine A, Jiang H, Butler W. Evidence for the presence of the platelet-activating factor receptor in the CFW mouse preimplantation two-cell-stage embryo. Biol Reprod. 1997;57:575-9 pubmed
    ..PAF's signal transduction mechanism in other cell types is receptor mediated. However, embryonic mRNA for the PAF receptor has not been detected...
  55. Liu J, Chen R, Marathe G, Febbraio M, Zou W, McIntyre T. Circulating platelet-activating factor is primarily cleared by transport, not intravascular hydrolysis by lipoprotein-associated phospholipase A2/ PAF acetylhydrolase. Circ Res. 2011;108:469-77 pubmed publisher
    ..3)H]PAF clearance was unchanged in PAF receptor(-/-) animals, or over the first 2 half-lives in PAF-AH(-/-) animals...
  56. Madeira M, Queiroz Junior C, Costa G, Werneck S, Cisalpino D, Garlet G, et al. Platelet-activating factor receptor blockade ameliorates Aggregatibacter actinomycetemcomitans-induced periodontal disease in mice. Infect Immun. 2013;81:4244-51 pubmed publisher
    ..actinomycetemcomitans in wild-type (WT) and PAF receptor knockout (Pafr(-/-)) mice. In vitro experiments using A...
  57. van Zoelen M, Florquin S, Meijers J, de Beer R, de Vos A, de Boer O, et al. Platelet-activating factor receptor contributes to host defense against Pseudomonas aeruginosa pneumonia but is not essential for the accompanying inflammatory and procoagulant response. J Immunol. 2008;180:3357-65 pubmed
    ..Platelet-activating factor receptor (PAFR) is involved in phagocytosis of several pathogens. To determine the role of PAFR in the innate immune response to P...
  58. Knapp S, von Aulock S, Leendertse M, Haslinger I, Draing C, Golenbock D, et al. Lipoteichoic acid-induced lung inflammation depends on TLR2 and the concerted action of TLR4 and the platelet-activating factor receptor. J Immunol. 2008;180:3478-84 pubmed
    ..In vitro data indicate roles for TLR2, platelet-activating factor receptor (PAFR), CD14, and LPS-binding protein (LBP) in cellular responsiveness to LTA, whereas the mechanisms contributing to LTA ..
  59. Plum L, Giesen K, Kluge R, Junger E, Linnartz K, Schurmann A, et al. Characterisation of the mouse diabetes susceptibilty locus Nidd/SJL: islet cell destruction, interaction with the obesity QTL Nob1, and effect of dietary fat. Diabetologia. 2002;45:823-30 pubmed
    ..g. Nob1) and islet cell failure ( Nidd/SJL). The combined diabetogenic effects of Nidd/SJL and Nob1 were markedly enhanced by a high-fat diet, whereas that of Nidd/SJL alone was independent of the dietary fat content. ..
  60. Mallet de Lima C, da Conceição Costa J, de Oliveira Lima Santos S, Carvalho S, de Carvalho L, Albano R, et al. Central role of PAFR signalling in ExoU-induced NF-?B activation. Cell Microbiol. 2014;16:1244-54 pubmed publisher
    ..aeruginosa strains. Several approaches showed that PAFR was crucially implicated in the activation of the canonical NF-?B pathway...
  61. Rodrigues D, Lacerda Queiroz N, de Miranda A, Fagundes C, Campos R, Arantes R, et al. Absence of PAF receptor alters cellular infiltrate but not rolling and adhesion of leukocytes in experimental autoimmune encephalomyelitis. Brain Res. 2011;1385:298-306 pubmed publisher
    ..Thus, in this study, we aimed to evaluate the role of PAF receptor in the pathogenesis of EAE. EAE was induced using an emulsion containing MOG(35-55)...
  62. Miller M, Gao G, Pestina T, Persons D, Tuomanen E. Hypersusceptibility to invasive pneumococcal infection in experimental sickle cell disease involves platelet-activating factor receptor. J Infect Dis. 2007;195:581-4 pubmed
    ..Platelet-activating factor receptor (PAFr) mediates pneumococcal invasion, and up-regulation of PAFr on chronically activated endothelia could contribute to ..
  63. Tokuoka S, Ishii S, Kawamura N, Satoh M, Shimada A, Sasaki S, et al. Involvement of platelet-activating factor and LIS1 in neuronal migration. Eur J Neurosci. 2003;18:563-70 pubmed
    ..We have previously shown the expression of PAF receptor in neurons and microglia...
  64. Yamaguchi M, Matsui M, Higa R, Yamazaki Y, Ikari A, Miyake M, et al. A platelet-activating factor (PAF) receptor deficiency exacerbates diet-induced obesity but PAF/PAF receptor signaling does not contribute to the development of obesity-induced chronic inflammation. Biochem Pharmacol. 2015;93:482-95 pubmed publisher
    ..In the present study, we investigated whether PAF/PAF receptor signaling contributed to chronic inflammation in the white adipose tissue (WAT) of PAF receptor-knockout (PAFR-..
  65. Moreno S, Alves Filho J, Rios Santos F, Silva J, Ferreira S, Cunha F, et al. Signaling via platelet-activating factor receptors accounts for the impairment of neutrophil migration in polymicrobial sepsis. J Immunol. 2006;177:1264-71 pubmed
    ..Using a PAFR antagonist, PCA-4248, and PAFR-deficient mice, we investigated whether signaling via PAFR was relevant for the ..
  66. Correa Costa M, Andrade Oliveira V, Braga T, Castoldi A, Aguiar C, Origassa C, et al. Activation of platelet-activating factor receptor exacerbates renal inflammation and promotes fibrosis. Lab Invest. 2014;94:455-66 pubmed publisher
    ..In the present study, we investigated the role of PAF receptor (PAFR) in an experimental model of chronic renal disease...
  67. Chen C, Magee J, Marcheselli V, Hardy M, Bazan N. Attenuated LTP in hippocampal dentate gyrus neurons of mice deficient in the PAF receptor. J Neurophysiol. 2001;85:384-90 pubmed
    ..Long-term potentiation (LTP) can be induced by the application of PAF and blocked by a PAF receptor (PAF-R) inhibitor in the hippocampal CA1 and dentate gyrus...
  68. Castor M, Rezende B, Resende C, Bernardes P, Cisalpino D, Vieira A, et al. Platelet-activating factor receptor plays a role in the pathogenesis of graft-versus-host disease by regulating leukocyte recruitment, tissue injury, and lethality. J Leukoc Biol. 2012;91:629-39 pubmed publisher
    ..The present study evaluated the relevance of PAFR for the pathogenesis of acute GVHD using a model of adoptive transfer of splenocytes from WT or PAFR(-/-) C57BL/6J ..
  69. Lacerda Queiroz N, Rachid M, Teixeira M, Teixeira A. The role of platelet-activating factor receptor (PAFR) in lung pathology during experimental malaria. Int J Parasitol. 2013;43:11-5 pubmed publisher
    ..Using mice lacking the PAF receptor (PAFR(-/-)) we investigated the relevance of signaling through the PAFR for the lung inflammatory process ..
  70. Onuchic A, Machado C, Saito R, Rios F, Jancar S, Chammas R. Expression of PAFR as part of a prosurvival response to chemotherapy: a novel target for combination therapy in melanoma. Mediators Inflamm. 2012;2012:175408 pubmed publisher
    Melanoma cells express the platelet-activating factor receptor (PAFR) and, thus, respond to PAF, a bioactive lipid produced by both tumour cells and those in the tumour microenvironment such as macrophages...
  71. Fukunaga A, Khaskhely N, Sreevidya C, Byrne S, Ullrich S. Dermal dendritic cells, and not Langerhans cells, play an essential role in inducing an immune response. J Immunol. 2008;180:3057-64 pubmed
    ..In contrast, applying DNFB to PAF receptor-deficient mice or mice injected with PAF receptor antagonists failed to induce LC migration...