Gene Symbol: Pstpip2
Description: proline-serine-threonine phosphatase-interacting protein 2
Alias: MAYP, cmo, proline-serine-threonine phosphatase-interacting protein 2, PEST phosphatase-interacting protein 2, macrophage actin-associated tyrosine-phosphorylated protein, pp37
Species: mouse
Products:     Pstpip2

Top Publications

  1. Wu Y, Dowbenko D, Lasky L. PSTPIP 2, a second tyrosine phosphorylated, cytoskeletal-associated protein that binds a PEST-type protein-tyrosine phosphatase. J Biol Chem. 1998;273:30487-96 pubmed
    ..These data suggest that a family of tyrosine phosphorylated, PEST PTP binding proteins may be implicated in cytoskeletal regulation. ..
  2. Yeung Y, Soldera S, Stanley E. A novel macrophage actin-associated protein (MAYP) is tyrosine-phosphorylated following colony stimulating factor-1 stimulation. J Biol Chem. 1998;273:30638-42 pubmed
    ..Termed macrophage actin-associated tyrosine-phosphorylated protein (MAYP), p37 is the major F-actin-associated protein that is tyrosine-phosphorylated in macrophages and is likely to play ..
  3. Chitu V, Pixley F, Macaluso F, Larson D, Condeelis J, Yeung Y, et al. The PCH family member MAYP/PSTPIP2 directly regulates F-actin bundling and enhances filopodia formation and motility in macrophages. Mol Biol Cell. 2005;16:2947-59 pubmed
    Macrophage actin-associated tyrosine phosphorylated protein (MAYP) belongs to the Pombe Cdc15 homology (PCH) family of proteins involved in the regulation of actin-based functions including cell adhesion and motility...
  4. Ferguson P, Bing X, Vasef M, Ochoa L, Mahgoub A, Waldschmidt T, et al. A missense mutation in pstpip2 is associated with the murine autoinflammatory disorder chronic multifocal osteomyelitis. Bone. 2006;38:41-7 pubmed
    ..3 Mb region on murine chromosome 18. Within the refined region was the gene pstpip2, which shares significant sequence homology to the PSTPIP1...
  5. Grosse J, Chitu V, Marquardt A, Hanke P, Schmittwolf C, Zeitlmann L, et al. Mutation of mouse Mayp/Pstpip2 causes a macrophage autoinflammatory disease. Blood. 2006;107:3350-8 pubmed
    Macrophage actin-associated tyrosine phosphorylated protein (MAYP)/PSTPIP2, a PCH protein, is involved in the regulation of macrophage motility...
  6. Chen T, Wu J, Chang W, Hsu P, Hsieh S, Shyu B. Spontaneous inflammatory pain model from a mouse line with N-ethyl-N-nitrosourea mutagenesis. J Biomed Sci. 2012;19:55 pubmed publisher
    ..A point mutation was detected at A to G in exon 8 of the pstpip2 gene, resulting in a conserved tyrosine residue at amino acid 180 replaced by cysteine (Y180 C)...
  7. Drobek A, Kralova J, Skopcova T, Kucova M, Novák P, Angelisová P, et al. PSTPIP2, a Protein Associated with Autoinflammatory Disease, Interacts with Inhibitory Enzymes SHIP1 and Csk. J Immunol. 2015;195:3416-26 pubmed publisher
    Mutations in the adaptor protein PSTPIP2 are the cause of the autoinflammatory disease chronic multifocal osteomyelitis in mice...
  8. Lukens J, Gross J, Calabrese C, Iwakura Y, Lamkanfi M, Vogel P, et al. Critical role for inflammasome-independent IL-1? production in osteomyelitis. Proc Natl Acad Sci U S A. 2014;111:1066-71 pubmed publisher
    ..Here, we characterized the osteoimmunological underpinnings of osteolytic bone disease in Pstpip2(cmo) mice...
  9. Byrd L, Grossmann M, Potter M, Shen Ong G. Chronic multifocal osteomyelitis, a new recessive mutation on chromosome 18 of the mouse. Genomics. 1991;11:794-8 pubmed
    ..Accordingly, we name the new mutation chronic multifocal osteomyelitis (cmo). Breeding analysis showed that the defect was determined by a single autosomal recessive gene...

More Information


  1. Chitu V, Ferguson P, de Bruijn R, Schlueter A, Ochoa L, Waldschmidt T, et al. Primed innate immunity leads to autoinflammatory disease in PSTPIP2-deficient cmo mice. Blood. 2009;114:2497-505 pubmed publisher
    The mouse Lupo (I282N) mutation in proline-serine-threonine phosphatase-interacting protein 2 (PSTPIP2) leads to reduced expression of PSTPIP2 that is associated with a macrophage-mediated autoinflammatory disease...
  2. Chitu V, Nacu V, Charles J, Henne W, McMahon H, Nandi S, et al. PSTPIP2 deficiency in mice causes osteopenia and increased differentiation of multipotent myeloid precursors into osteoclasts. Blood. 2012;120:3126-35 pubmed publisher
    ..myeloid cell expression of the F-BAR domain protein, proline serine threonine phosphatase-interacting protein 2 (PSTPIP2), lead to autoinflammatory disease involving extramedullary hematopoiesis, skin and bone lesions...
  3. Tsujita K, Kondo A, Kurisu S, Hasegawa J, Itoh T, Takenawa T. Antagonistic regulation of F-BAR protein assemblies controls actin polymerization during podosome formation. J Cell Sci. 2013;126:2267-78 pubmed publisher
    ..Here, we demonstrate that the assembly of FBP17 on the plasma membranes is antagonized by PSTPIP2, another F-BAR protein implicated in auto-inflammatory disorder...
  4. CASSEL S, Janczy J, Bing X, Wilson S, Olivier A, Otero J, et al. Inflammasome-independent IL-1? mediates autoinflammatory disease in Pstpip2-deficient mice. Proc Natl Acad Sci U S A. 2014;111:1072-7 pubmed publisher
    ..Missense mutation (L98P) of proline-serine-threonine phosphatase-interacting protein 2 (Pstpip2) in mice leads to a disease that is phenotypically similar to CRMO called chronic multifocal osteomyelitis (cmo)...
  5. Lukens J, Gurung P, Vogel P, Johnson G, Carter R, McGoldrick D, et al. Dietary modulation of the microbiome affects autoinflammatory disease. Nature. 2014;516:246-9 pubmed publisher
    ..b>Pstpip2(cmo) mice, which express a homozygous Leu98Pro missense mutation in the Pombe Cdc15 homology family protein ..
  6. Liao H, Chyuan I, Wu C, Lin S, Chen K, Tsai H, et al. Increased neutrophil infiltration, IL-1 production and a SAPHO syndrome-like phenotype in PSTPIP2-deficient mice. Rheumatology (Oxford). 2015;54:1317-26 pubmed publisher
    Proline-serine-threonine-phosphatase-interacting protein 2 (PSTPIP2) is involved in macrophage activation, neutrophil motility and osteoclast differentiation...
  7. Hentunen T, Choi S, Boyce B, Dallas M, Dallas S, Shen Ong G, et al. A murine model of inflammatory bone disease. Bone. 2000;26:183-8 pubmed
    ..Accordingly, this new mutation was named "CMO." In this report, we describe the histology of bones in CMO mice, as well as the capacity of the bone marrow ..
  8. Gurung P, Burton A, Kanneganti T. NLRP3 inflammasome plays a redundant role with caspase 8 to promote IL-1?-mediated osteomyelitis. Proc Natl Acad Sci U S A. 2016;113:4452-7 pubmed publisher
    Missense mutation in the proline-serine-threonine phosphatase-interacting protein 2 (Pstpip2) gene results in the development of spontaneous chronic bone disease characterized by bone deformity and inflammation that is reminiscent of ..
  9. Sztacho M, Segeletz S, Sanchez Fernandez M, Czupalla C, Niehage C, Hoflack B. BAR Proteins PSTPIP1/2 Regulate Podosome Dynamics and the Resorption Activity of Osteoclasts. PLoS ONE. 2016;11:e0164829 pubmed publisher
    ..Whereas PSTPIP2 regulates podosome assembly, PSTPIP1 regulates their disassembly...
  10. Govoni M, Colina M, Massara A, Trotta F. "SAPHO syndrome and infections". Autoimmun Rev. 2009;8:256-9 pubmed publisher
    ..The current concept of SAPHO syndrome as a reactive infectious osteitis in genetic predisposed subjects seems appealing, but it has not been yet demonstrated...