Psme1

Summary

Gene Symbol: Psme1
Description: proteasome (prosome, macropain) 28 subunit, alpha
Alias: AW413925, PA28a, 11S regulator complex subunit alpha, PA28 alpha subunit, PA28alpha, REG-alpha, activator of multicatalytic protease subunit 1, protease (prosome, macropain) 28 subunit, alpha, proteasome activator 28 subunit alpha, proteasome activator complex subunit 1
Species: mouse

Top Publications

  1. ncbi A role for the proteasome regulator PA28alpha in antigen presentation
    M Groettrup
    Institute for Biochemistry, Medical Faculty Charité, Humboldt University, Berlin, Germany
    Nature 381:166-8. 1996
  2. ncbi Impaired immunoproteasome assembly and immune responses in PA28-/- mice
    T Preckel
    The R W Johnson Pharmaceutical Research Institute, 3210 Merryfield Row, San Diego, CA 92121, USA
    Science 286:2162-5. 1999
  3. ncbi Immunoproteasome assembly and antigen presentation in mice lacking both PA28alpha and PA28beta
    S Murata
    Department of Molecular Oncology, Tokyo Metropolitan Institute of Medical Science, and CREST, Japan Science and Technology Corporation, Tokyo 113 8613, Japan
    EMBO J 20:5898-907. 2001
  4. ncbi Antigen presentation by MHC class I and its regulation by interferon gamma
    K Fruh
    The R W Johnson Pharmaceutical Research Institute, General Atomics Court, San Diego, CA 92121, USA
    Curr Opin Immunol 11:76-81. 1999
  5. ncbi The ubiquitin-proteasome system plays essential roles in presenting an 8-mer CTL epitope expressed in APC to corresponding CD8+ T cells
    Xuefeng Duan
    Department of Microbiology and Immunology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Int Immunol 18:679-87. 2006
  6. ncbi Differential expression regulation of the alpha and beta subunits of the PA28 proteasome activator in mature dendritic cells
    Ferry Ossendorp
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    J Immunol 174:7815-22. 2005
  7. ncbi Allele-selective effect of PA28 in MHC class I antigen processing
    Taketoshi Yamano
    Laboratory for Immunochaperones, Research Center for Allergy and Immunology, RIKEN Yokohama Institute, Tsurumi, Yokohama, Japan
    J Immunol 181:1655-64. 2008
  8. ncbi Immunoproteasomes down-regulate presentation of a subdominant T cell epitope from lymphocytic choriomeningitis virus
    Michael Basler
    Division of Immunology, Department of Biology, University of Constance, Konstanz, Germany
    J Immunol 173:3925-34. 2004
  9. ncbi Enhancement of proteasome function by PA28α overexpression protects against oxidative stress
    Jie Li
    Division of Basic Biomedical Sciences, Sanford School of Medicine of the University of South Dakota, 414 East Clark St, Lee Medical Bldg, Vermillion, SD 57069, USA
    FASEB J 25:883-93. 2011
  10. ncbi Two distinct pathways mediated by PA28 and hsp90 in major histocompatibility complex class I antigen processing
    Taketoshi Yamano
    Department of Molecular Medicine, Division of Immunology, Nagasaki University School of Medicine, Nagasaki 852 8523, Japan
    J Exp Med 196:185-96. 2002

Scientific Experts

  • M Kasahara
  • K Fruh
  • Tomoki Chiba
  • Taketoshi Yamano
  • Keiji Tanaka
  • Shigeo Murata
  • K Tanaka
  • Jie Li
  • Natascha de Graaf
  • K Kohda
  • S Murata
  • Xuefeng Duan
  • Ferry Ossendorp
  • Heiichiro Udono
  • Katsuyuki Yui
  • Michael Basler
  • T Ishibashi
  • M V McGuire
  • M Yawata
  • Peter Michael Kloetzel
  • David J Topham
  • Mary J G van Helden
  • Saul R Powell
  • Kathrin Textoris-Taube
  • Alice J A M Sijts
  • Dietmar M W Zaiss
  • Xuejun Wang
  • Shusaku Mizukami
  • Hidetoshi Sugahara
  • T Preckel
  • Y Yao
  • Liping Tu
  • Kunisuke Himeno
  • Takaomi Koga
  • Hans Jörg Fehling
  • Bin Chou
  • Hajime Hisaeda
  • Katsuo Sueishi
  • JianYing Shen
  • Takashi Imai
  • Grayson B Lipford
  • Peter J van den Elsen
  • Peter M Kloetzel
  • Danita Schuurhuis
  • Y Matsuda
  • Alice Sijts
  • Nathalie Fu
  • Marcel Camps
  • Paola Ricciardi-Castagnoli
  • Francesca Granucci
  • Gosse J Adema
  • Sam J P Gobin
  • Peter-M Kloetzel
  • Cornelis J M Melief
  • Nikolay Youhnovski
  • Maries Van Den Broek
  • Marcus Groettrup
  • E Kandil
  • H Jiang
  • Michael Przybylski
  • Noriaki Tanaka
  • Naoki Shimbara
  • M Groettrup
  • Y Ishigatsubo
  • K Adachi
  • N Tanahashi
  • K Yui
  • H Udono
  • T Yamano
  • N Kobayashi
  • K Watanabe
  • N R Gascoigne
  • N Hamada
  • T Chiba
  • P Suthipinijtham
  • Y Yang
  • L Salter-Cid
  • T G Wolfe
  • Y Wu
  • C C Wang
  • A Krutchinsky
  • A Vitiello
  • P Ghazal
  • P A Peterson
  • J D Lee
  • K G Standing
  • O Winqvist
  • A Angulo
  • K Ngo
  • M Von Herrath

Detail Information

Publications18

  1. ncbi A role for the proteasome regulator PA28alpha in antigen presentation
    M Groettrup
    Institute for Biochemistry, Medical Faculty Charité, Humboldt University, Berlin, Germany
    Nature 381:166-8. 1996
    ..the murine cytomegalovirus pp89 protein was transfected with either the human or murine gene encoding the PA28alpha subunit, which is sufficient to activate the peptide-hydrolysing activity of the 20S proteasome in vitro...
  2. ncbi Impaired immunoproteasome assembly and immune responses in PA28-/- mice
    T Preckel
    The R W Johnson Pharmaceutical Research Institute, 3210 Merryfield Row, San Diego, CA 92121, USA
    Science 286:2162-5. 1999
    In vitro PA28 binds and activates proteasomes. It is shown here that mice with a disrupted PA28b gene lack PA28a and PA28b polypeptides, demonstrating that PA28 functions as a hetero-oligomer in vivo...
  3. ncbi Immunoproteasome assembly and antigen presentation in mice lacking both PA28alpha and PA28beta
    S Murata
    Department of Molecular Oncology, Tokyo Metropolitan Institute of Medical Science, and CREST, Japan Science and Technology Corporation, Tokyo 113 8613, Japan
    EMBO J 20:5898-907. 2001
    Two members of the proteasome activator, PA28alpha and PA28beta, form a heteropolymer that binds to both ends of the 20S proteasome...
  4. ncbi Antigen presentation by MHC class I and its regulation by interferon gamma
    K Fruh
    The R W Johnson Pharmaceutical Research Institute, General Atomics Court, San Diego, CA 92121, USA
    Curr Opin Immunol 11:76-81. 1999
    ..Thus, a rather complex picture emerges for the rules governing peptide production in the presence or absence of IFN-gamma...
  5. ncbi The ubiquitin-proteasome system plays essential roles in presenting an 8-mer CTL epitope expressed in APC to corresponding CD8+ T cells
    Xuefeng Duan
    Department of Microbiology and Immunology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Int Immunol 18:679-87. 2006
    ..Furthermore, mice deficient in a proteasome regulator, PA28alpha/beta, failed to acquire protective immunity...
  6. ncbi Differential expression regulation of the alpha and beta subunits of the PA28 proteasome activator in mature dendritic cells
    Ferry Ossendorp
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    J Immunol 174:7815-22. 2005
    ..In the present study, we show that expression of PA28alpha and beta subunits was differentially regulated...
  7. ncbi Allele-selective effect of PA28 in MHC class I antigen processing
    Taketoshi Yamano
    Laboratory for Immunochaperones, Research Center for Allergy and Immunology, RIKEN Yokohama Institute, Tsurumi, Yokohama, Japan
    J Immunol 181:1655-64. 2008
    ..Retrovirus-transduced overexpression of PA28alpha decreased expression of K(d) (D(d)) while it increased K(b) and L(d) on the cell surface...
  8. ncbi Immunoproteasomes down-regulate presentation of a subdominant T cell epitope from lymphocytic choriomeningitis virus
    Michael Basler
    Division of Immunology, Department of Biology, University of Constance, Konstanz, Germany
    J Immunol 173:3925-34. 2004
    ..Taken together, we show that LMP2 and LMP7 can at least in part determine subdominance and shape the epitope hierarchy of CTL responses in vivo...
  9. ncbi Enhancement of proteasome function by PA28α overexpression protects against oxidative stress
    Jie Li
    Division of Basic Biomedical Sciences, Sanford School of Medicine of the University of South Dakota, 414 East Clark St, Lee Medical Bldg, Vermillion, SD 57069, USA
    FASEB J 25:883-93. 2011
    ....
  10. ncbi Two distinct pathways mediated by PA28 and hsp90 in major histocompatibility complex class I antigen processing
    Taketoshi Yamano
    Department of Molecular Medicine, Division of Immunology, Nagasaki University School of Medicine, Nagasaki 852 8523, Japan
    J Exp Med 196:185-96. 2002
    ..Geldanamycin, an inhibitor of hsp90, almost completely suppressed OVA antigen presentation in PA28alpha(-/-)/beta(-/-) lipopolysaccharide blasts, but not in wild-type cells, indicating that hsp90 compensates for the ..
  11. ncbi The mouse Supt16h/Fact140 gene, encoding part of the FACT chromatin transcription complex, maps close to Tcra and is highly expressed in thymus
    M V McGuire
    Department of Immunology, IMM1, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Mamm Genome 12:664-7. 2001
  12. ncbi Nucleotide sequence analysis of the approximately 35-kb segment containing interferon-gamma-inducible mouse proteasome activator genes
    M Yawata
    CREST, Japan Science and Technology Corporation JST, Hayama 240 0193, Japan
    Immunogenetics 53:119-29. 2001
    ..Previously, we showed that the genes coding for PA28 alpha and PA28 beta, designated Psme1 and Psme2, respectively, are located approximately 6 kb apart with their 3' ends pointing toward each other on ..
  13. ncbi Structural and functional characterizations of the proteasome-activating protein PA26 from Trypanosoma brucei
    Y Yao
    Department of Pharmaceutical Chemistry, Howard Hughes Medical Institute, University of California, San Francisco, California 94143, USA
    J Biol Chem 274:33921-30. 1999
    ..5 nm. The ring binds and activates 20 S proteasomes from T. brucei as well as rat, whereas human PA28alpha can neither bind nor activate T. brucei 20 S proteasome...
  14. ncbi Characterization of the mouse PA28 activator complex gene family: complete organizations of the three member genes and a physical map of the approximately 150-kb region containing the alpha- and beta-subunit genes
    K Kohda
    Department of Biochemistry, Hokkaido University School of Medicine, Sapporo, Japan
    J Immunol 160:4923-35. 1998
    ..In this study, we describe the complete nucleotide sequences of the mouse genes, Psme1, Psme2, and Psme3, coding for the alpha-, beta-, and gamma-subunits, respectively...
  15. ncbi Structural analysis and chromosomal localization of the mouse Psmb5 gene coding for the constitutively expressed beta-type proteasome subunit
    K Kohda
    Department of Biochemistry, Hokkaido University School of Medicine, Sapporo 060, Japan
    Immunogenetics 47:77-87. 1997
    ..These results were confirmed by fluorescent in situ hybridization analysis that localized Psmb5 to band C2 to proximal D1 of chromosome 14 and Psmb5-ps to band D of chromosome 11...
  16. ncbi PA28 subunits of the mouse proteasome: primary structures and chromosomal localization of the genes
    E Kandil
    Department of Biochemistry, Hokkaido University School of Medicine, Sapporo 060, Japan
    Immunogenetics 46:337-44. 1997
    ..Interspecific backcross mapping showed that the mouse genes coding for the alpha- and beta-subunits (designated Psme1 and Psme2, respectively) are tightly linked and map close to the Atp5g1 locus on chromosome 14...
  17. ncbi Sequence and expression of mouse proteasome activator PA28 and the related autoantigen Ki
    H Jiang
    Graduate Program in Cell Biology, Department of Cell Biology, Neurobiology, and Anatomy, University of Cincinnati, 231 Bethesda Avenue, Cincinnati, OH 45 267 0521, USA
    Immunogenetics 46:93-8. 1997
    ..cloned and sequenced full-length mouse cDNAs for the two homologous subunits of the proteasome activator PA28 (PA28alpha and PA28beta), as well as for the related protein Ki. These proteins are highly conserved among species...
  18. ncbi PA28 and the proteasome immunosubunits play a central and independent role in the production of MHC class I-binding peptides in vivo
    Natascha de Graaf
    Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, University of Utrecht, Utrecht, The Netherlands
    Eur J Immunol 41:926-35. 2011
    ....