Psmb9

Summary

Gene Symbol: Psmb9
Description: proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)
Alias: Lmp-2, Lmp2, proteasome subunit beta type-9, LMP-2d, large multifunctional protease 2, low molecular mass protein 2, macropain chain 7, multicatalytic endopeptidase complex chain 7, proteasome chain 7, proteasome subunit beta-1i, proteosome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2), proteosome beta 9 subunit, really interesting new gene 12 protein
Species: mouse
Products:     Psmb9

Top Publications

  1. van Kaer L, Ashton Rickardt P, Eichelberger M, Gaczynska M, Nagashima K, Rock K, et al. Altered peptidase and viral-specific T cell response in LMP2 mutant mice. Immunity. 1994;1:533-41 pubmed
    ..Two proteasomal subunits, LMP2 and LMP7, are encoded within the MHC class II region, but their precise role in antigen processing is unknown...
  2. Nussbaum A, Rodriguez Carreno M, Benning N, Botten J, Whitton J. Immunoproteasome-deficient mice mount largely normal CD8+ T cell responses to lymphocytic choriomeningitis virus infection and DNA vaccination. J Immunol. 2005;175:1153-60 pubmed
    ..virus infection and DNA immunization in wild-type mice and in mice lacking the immunoproteasome subunits LMP2 or LMP7...
  3. Hayashi T, Faustman D. NOD mice are defective in proteasome production and activation of NF-kappaB. Mol Cell Biol. 1999;19:8646-59 pubmed
    ..We have identified in NOD lymphocytes a specific proteasome defect that results from the lack of the LMP2 subunit...
  4. Nil A, Firat E, Sobek V, Eichmann K, Niedermann G. Expression of housekeeping and immunoproteasome subunit genes is differentially regulated in positively and negatively selecting thymic stroma subsets. Eur J Immunol. 2004;34:2681-9 pubmed
    ..Absence of LMP2 altered thymic selection of the MHC class I-restricted transgenic P14 TCR in KO mice...
  5. Hayashi T, Faustman D. Development of spontaneous uterine tumors in low molecular mass polypeptide-2 knockout mice. Cancer Res. 2002;62:24-7 pubmed
    ..the proteasome pathway, a process that is influenced by the IFN-gamma-inducible low molecular mass polypeptide-2 (LMP2) subunit of the proteasome complex. LMP2 knockout mice thus exhibit a defect in proteasome function...
  6. de Graaf N, van Helden M, Textoris Taube K, Chiba T, Topham D, Kloetzel P, et al. PA28 and the proteasome immunosubunits play a central and independent role in the production of MHC class I-binding peptides in vivo. Eur J Immunol. 2011;41:926-35 pubmed publisher
  7. Marques L, Brucet M, Lloberas J, Celada A. STAT1 regulates lipopolysaccharide- and TNF-alpha-dependent expression of transporter associated with antigen processing 1 and low molecular mass polypeptide 2 genes in macrophages by distinct mechanisms. J Immunol. 2004;173:1103-10 pubmed
    Transporter associated with Ag processing 1 and low molecular mass polypeptide 2 (LMP2) are essential for class I MHC function and share a common bidirectional promoter...
  8. Pang K, Sanders M, Monaco J, Doherty P, Turner S, Chen W. Immunoproteasome subunit deficiencies impact differentially on two immunodominant influenza virus-specific CD8+ T cell responses. J Immunol. 2006;177:7680-8 pubmed
    ..Together, these results provide a clearer understanding of how immunodominance hierarchies are established. ..
  9. Caudill C, Jayarapu K, Elenich L, Monaco J, Colbert R, Griffin T. T cells lacking immunoproteasome subunits MECL-1 and LMP7 hyperproliferate in response to polyclonal mitogens. J Immunol. 2006;176:4075-82 pubmed
    ..comprise a specialized subset of proteasomes that is defined by the presence of three catalytic immunosubunits: LMP2, MECL-1 (LMP10), and LMP7...

More Information

Publications67

  1. Hensley S, Zanker D, Dolan B, David A, Hickman H, Embry A, et al. Unexpected role for the immunoproteasome subunit LMP2 in antiviral humoral and innate immune responses. J Immunol. 2010;184:4115-22 pubmed publisher
    ..In this study, we report that the presence of mixed proteasomes in immune cells in LMP2(-/-) mice compromises multiple components that contribute to the generation of antiviral Ab responses, including ..
  2. Moebius J, Van Den Broek M, Groettrup M, Basler M. Immunoproteasomes are essential for survival and expansion of T cells in virus-infected mice. Eur J Immunol. 2010;40:3439-49 pubmed publisher
    Immunoproteasomes containing the IFN-inducible subunits ?1i (LMP2), ?2i (MECL-1) and ?5i (LMP7) alter proteasomal cleavage preference and optimize the generation of peptide ligands of MHC class I molecules...
  3. Basler M, Youhnovski N, Van Den Broek M, Przybylski M, Groettrup M. Immunoproteasomes down-regulate presentation of a subdominant T cell epitope from lymphocytic choriomeningitis virus. J Immunol. 2004;173:3925-34 pubmed
    ..Overexpression of the active site subunits of immunoproteasomes LMP2, LMP7, and MECL-1 as well as overexpression of LMP2 alone suppressed the presentation of the gp276-286 epitope...
  4. Johnsen A, France J, Nagy N, Askew D, Abdul Karim F, Gerson S, et al. Systemic deficits in transporter for antigen presentation (TAP)-1 or proteasome subunit LMP2 have little or no effect on tumor incidence. Int J Cancer. 2001;91:366-72 pubmed
    ..deficits in T-cell immunity, including mice lacking TAP1 (a subunit of the transporter for antigen presentation) or LMP2 (a regulated subunit of the 20S proteasome)...
  5. Qian M, Pang Y, Liu C, Haratake K, Du B, Ji D, et al. Acetylation-mediated proteasomal degradation of core histones during DNA repair and spermatogenesis. Cell. 2013;153:1012-24 pubmed publisher
    ..Thus, PA200/Blm10 specifically targets the core histones for acetylation-mediated degradation by proteasomes, providing mechanisms by which acetylation regulates histone degradation, DNA repair, and spermatogenesis. ..
  6. Zheng P, Guo Y, Niu Q, Levy D, Dyck J, Lu S, et al. Proto-oncogene PML controls genes devoted to MHC class I antigen presentation. Nature. 1998;396:373-6 pubmed
    ..PML also regulates MHC expression in untransformed fibroblasts. We conclude that malfunction of PML may enable a tumour to evade the immune defence of its host. ..
  7. Ikegami H, Makino S, Yamato E, Kawaguchi Y, Ueda H, Sakamoto T, et al. Identification of a new susceptibility locus for insulin-dependent diabetes mellitus by ancestral haplotype congenic mapping. J Clin Invest. 1995;96:1936-42 pubmed
    ..Our results not only map a new MHC-linked diabetogenic gene(s) but also suggest a new way to fine map disease susceptibility genes within a region where strong linkage disequilibrium exists. ..
  8. Nandi D, Iyer M, Monaco J. Molecular and serological analysis of polymorphisms in the murine major histocompatibility complex-encoded proteasome subunits, LMP-2 and LMP-7. Exp Clin Immunogenet. 1996;13:20-9 pubmed
  9. Mizuno K, Koide T, Sagai T, Moriwaki K, Shiroishi T. Molecular analysis of a recombinational hotspot adjacent to Lmp2 gene in the mouse MHC: fine location and chromatin structure. Mamm Genome. 1996;7:490-6 pubmed
    ..one of such hotspots, previously mapped between the Pb and Ob genes, is located very close to the 3' end of the Lmp2 gene, which encodes a subunit of a proteolytic proteasome...
  10. Peleraux A, Karlsson L, Chambers J, Peterson P. Genomic organization of a mouse MHC class II region including the H2-M and Lmp2 loci. Immunogenetics. 1996;43:204-14 pubmed
    The region encompassing the Ma, Mb1, Mb2, and Lmp2 genes of the mouse class II major histocompatibility complex (MHC) was sequenced...
  11. Frausto R, Crocker S, Eam B, Whitmire J, Whitton J. Myelin oligodendrocyte glycoprotein peptide-induced experimental allergic encephalomyelitis and T cell responses are unaffected by immunoproteasome deficiency. J Neuroimmunol. 2007;192:124-33 pubmed
  12. Murata S, Sasaki K, Kishimoto T, Niwa S, Hayashi H, Takahama Y, et al. Regulation of CD8+ T cell development by thymus-specific proteasomes. Science. 2007;316:1349-53 pubmed
    ..Our results suggest a key role for beta5t in generating the MHC class I-restricted CD8(+) T cell repertoire during thymic selection. ..
  13. Tu L, Moriya C, Imai T, Ishida H, Tetsutani K, Duan X, et al. Critical role for the immunoproteasome subunit LMP7 in the resistance of mice to Toxoplasma gondii infection. Eur J Immunol. 2009;39:3385-94 pubmed publisher
    ..Immunoproteasomes, defined by the presence of the three catalytic subunits LMP2, MECL-1, and LMP7, have been hypothesized to optimize MHC class I antigen processing...
  14. Hayashi T, Faustman D. Selected contribution: Association of gender-related LMP2 inactivation with autoimmune pathogenesis. J Appl Physiol (1985). 2001;91:2804-15 pubmed
    ..Two such genes encoding the LMP2 and LMP7 proteasome subunits are located in this high-risk MHC genomic region...
  15. Callahan M, Wohlfert E, Menoret A, Srivastava P. Heat shock up-regulates lmp2 and lmp7 and enhances presentation of immunoproteasome-dependent epitopes. J Immunol. 2006;177:8393-9 pubmed
    ..We report that two inducible subunits of the proteasome, lmp2 and lmp7, are transcriptionally up-regulated by heat shock in cells of mouse and human origin...
  16. van Endert P. Genes regulating MHC class I processing of antigen. Curr Opin Immunol. 1999;11:82-8 pubmed
    ..Finally, genetic evidence suggests an important influence of an unidentified gene, in the MHC complex, on MHC class I processing...
  17. Shiroishi T, Hanzawa N, Sagai T, Ishiura M, Gojobori T, Steinmetz M, et al. Recombinational hotspot specific to female meiosis in the mouse major histocompatibility complex. Immunogenetics. 1990;31:79-88 pubmed
    ..Each hotspot consists of two elements, the consensus sequence of the mouse middle repetitive MT family and the tetrameric repeated sequences, which are separated by 1 kb of DNA. ..
  18. van Helden M, de Graaf N, Bekker C, Boog C, Zaiss D, Sijts A. Immunoproteasome-deficiency has no effects on NK cell education, but confers lymphocytes into targets for NK cells in infected wild-type mice. PLoS ONE. 2011;6:e23769 pubmed publisher
  19. Brown M, Driscoll J, Monaco J. MHC-linked low-molecular mass polypeptide subunits define distinct subsets of proteasomes. Implications for divergent function among distinct proteasome subsets. J Immunol. 1993;151:1193-204 pubmed
    ..Distinct forms of proteasomes share a hypothetical core to which unique subunits are added. One of these subsets, LMP2+ proteasome, contains the product of the MHC-linked Lmp-2 gene, and can be distinguished serologically and ..
  20. Basler M, Lauer C, Moebius J, Weber R, Przybylski M, Kisselev A, et al. Why the structure but not the activity of the immunoproteasome subunit low molecular mass polypeptide 2 rescues antigen presentation. J Immunol. 2012;189:1868-77 pubmed publisher
    ..Experiments with LMP2-deficient splenocytes revealed that the generation of the male HY-derived CTL-epitope UTY(246-254) was dependent on ..
  21. Cai Z, Shen Z, Van Kaer L, Becker L. Ischemic preconditioning-induced cardioprotection is lost in mice with immunoproteasome subunit low molecular mass polypeptide-2 deficiency. FASEB J. 2008;22:4248-57 pubmed publisher
    ..In conclusion, LMP-2 is required for normal proteasomal function and IPC induction in the heart. Its action may be related to PTEN protein degradation. ..
  22. Singh S, Awasthi N, Egwuagu C, Wagner B. Immunoproteasome expression in a nonimmune tissue, the ocular lens. Arch Biochem Biophys. 2002;405:147-53 pubmed
    ..The presence of immuno subunits in nonimmune tissues such as lens suggests that the immunoproteasome may also have nonimmune functions, such as that in lens differentiation. ..
  23. Zhou P, Zanelli E, Smart M, David C. Genomic organization and tissue expression of mouse proteasome gene Lmp-2. Genomics. 1993;16:664-8 pubmed
    ..gene consists of six exons, and its genomic organization is very similar to that of the recently described human LMP2 gene...
  24. Kincaid E, Che J, York I, Escobar H, Reyes Vargas E, Delgado J, et al. Mice completely lacking immunoproteasomes show major changes in antigen presentation. Nat Immunol. 2011;13:129-35 pubmed publisher
    ..These results indicated that immunoproteasomes were more important in antigen presentation than previously thought. ..
  25. Kalim K, Basler M, Kirk C, Groettrup M. Immunoproteasome subunit LMP7 deficiency and inhibition suppresses Th1 and Th17 but enhances regulatory T cell differentiation. J Immunol. 2012;189:4182-93 pubmed publisher
    ..LMP7 governs Th cell lineage determination by affecting the balance of receptor proximal signals during differentiation. These data render LMP7 a promising drug target for the treatment of autoimmune diseases. ..
  26. Cui Z, Hwang S, Gomes A. Identification of the immunoproteasome as a novel regulator of skeletal muscle differentiation. Mol Cell Biol. 2014;34:96-109 pubmed publisher
    ..Knockdown of the i-proteasome catalytic subunit PSMB9 by short hairpin RNA (shRNA) decreased the expression of both PSMB9 and PSMB8 without affecting other catalytic ..
  27. Hayashi T, Horiuchi A, Sano K, Yaegashi N, Konishi I. Uterine Leiomyosarcoma Tumorigenesis in Lmp2-deficient Mice: Involvement of Impaired Anti-oncogenic Factor IRF1. Anticancer Res. 2015;35:4665-79 pubmed
    ..We have previously reported that low molecular mass protein2 Lmp2-deficient mice spontaneously developed Ut-LMS, which implicated this protein as an anti-oncogenic candidate...
  28. Puttaparthi K, Van Kaer L, Elliott J. Assessing the role of immuno-proteasomes in a mouse model of familial ALS. Exp Neurol. 2007;206:53-8 pubmed
    ..what role immuno-proteasomes may have in mutant SOD1-induced disease, we crossed G93A SOD1 transgenic mice with LMP2-/- mice to obtain G93A SOD1 mice lacking the LMP2 immuno-proteasome subunit...
  29. Martinez C, Monaco J. Post-translational processing of a major histocompatibility complex-encoded proteasome subunit, LMP-2. Mol Immunol. 1993;30:1177-83 pubmed
    ..Determination of the location of intron/exon boundaries in the Lmp-2 gene indicated that these residues correspond precisely to the first exon of the gene. ..
  30. Yoshino M, Sagai T, Lindahl K, Toyoda Y, Shiroishi T, Moriwaki K. No dosage effect of recombinational hotspots in the mouse major histocompatibility complex. Immunogenetics. 1994;39:381-9 pubmed
    ..Twenty-three breakpoints were confined within 5.4 kb in the Lmp-2 hotspot, and six breakpoints from the cas4 cross were located in the Pb hotspot, which we have now confined to a 15 kb segment. ..
  31. Kopach P, Lockatell V, Pickering E, Haskell R, Anderson R, Hasday J, et al. IFN-? directly controls IL-33 protein level through a STAT1- and LMP2-dependent mechanism. J Biol Chem. 2014;289:11829-43 pubmed publisher
    ..Stimulation with IFN-? strongly elevated the levels of the LMP2 proteasome subunit, known for its role in IFN-?-regulated antigen processing...
  32. Kimura H, Chen C, Tzou S, Rocchi R, Landek Salgado M, Suzuki K, et al. Immunoproteasome overexpression underlies the pathogenesis of thyroid oncocytes and primary hypothyroidism: studies in humans and mice. PLoS ONE. 2009;4:e7857 pubmed publisher
    ..analysis comparing transgenic to wild type thyrocytes revealed increased levels of immunoproteasome subunits like LMP2 in transgenics, suggesting an important role of the immunoproteasome in oncocyte pathogenesis...
  33. Basler M, Dajee M, Moll C, Groettrup M, Kirk C. Prevention of experimental colitis by a selective inhibitor of the immunoproteasome. J Immunol. 2010;185:634-41 pubmed publisher
    ..Colitis induction in LMP2-, LMP7-, and multicatalytic endopeptidase complex-like-1-deficient mice caused reduced weight loss compared with ..
  34. Mundt S, Engelhardt B, Kirk C, Groettrup M, Basler M. Inhibition and deficiency of the immunoproteasome subunit LMP7 attenuates LCMV-induced meningitis. Eur J Immunol. 2016;46:104-13 pubmed publisher
    ..Our findings support the important role of LMP7 in inflammatory disorders and suggest immunoproteasome inhibition as a novel strategy against inflammation-induced neuropathology in the CNS. ..
  35. Monaco J, McDevitt H. The LMP antigens: a stable MHC-controlled multisubunit protein complex. Hum Immunol. 1986;15:416-26 pubmed
    ..In this article we will review the biochemistry, serology, and genetics of the LMP antigens, and will speculate on their biological function. ..
  36. Yoshino M, Sagai T, Moriwaki K, Shiroishi T. Meiotic recombination at the Lmp2 hotspot tolerates minor sequence divergence between homologous chromosomes. Immunogenetics. 1996;43:80-2 pubmed
  37. Fruh K, Yang Y, Arnold D, Chambers J, Wu L, Waters J, et al. Alternative exon usage and processing of the major histocompatibility complex-encoded proteasome subunits. J Biol Chem. 1992;267:22131-40 pubmed
    The finding that two subunits of the proteasome, LMP2 and LMP7, are encoded in the major histocompatibility complex (MHC) has linked the proteasome which represents a major extralysosomal proteolytic system to the processing of ..
  38. Fruh K, Yang Y. Antigen presentation by MHC class I and its regulation by interferon gamma. Curr Opin Immunol. 1999;11:76-81 pubmed
    ..Thus, a rather complex picture emerges for the rules governing peptide production in the presence or absence of IFN-gamma. ..
  39. Yan G, Fu Y, Faustman D. Reduced expression of Tap1 and Lmp2 antigen-processing genes in the nonobese diabetic (NOD) mouse due to a mutation in their shared bidirectional promoter. J Immunol. 1997;159:3068-80 pubmed
    The MHC is an essential contributor to autoimmunity. Lmp2 and Tap1 are genes located in the MHC class II region, and they encode proteins participating in the generation and transport of endogenous peptides for T cell education...
  40. Martin S, Gee J, Bruce Keller A, Keller J. Loss of an individual proteasome subunit alters motor function but not cognitive function or ambulation in mice. Neurosci Lett. 2004;357:76-8 pubmed
    ..motor function, cognitive function, and ambulation in transgenic mice that lack the low molecular protein 2 (LMP2) proteasome subunit...
  41. Hayashi M, Ishibashi T, Tanaka K, Kasahara M. The mouse genes encoding the third pair of beta-type proteasome subunits regulated reciprocally by IFN-gamma: structural comparison, chromosomal localization, and analysis of the promoter. J Immunol. 1997;159:2760-70 pubmed
    ..When cells are stimulated with IFN-gamma, two MHC-encoded subunits, low Mr polypeptide 2 (LMP2) and LMP7, are incorporated into the proteasomal complex by displacing the housekeeping subunits, designated Y and ..
  42. Kozak C, Gatignol A, Graham K, Jeang K, McBride O. Genetic mapping in human and mouse of the locus encoding TRBP, a protein that binds the TAR region of the human immunodeficiency virus (HIV-1). Genomics. 1995;25:66-72 pubmed
    ..Western blotting indicates that despite high sequence conservation in human and mouse, the TARBP2 protein differs in apparent size in primate and rodent cells. ..
  43. Basler M, Beck U, Kirk C, Groettrup M. The antiviral immune response in mice devoid of immunoproteasome activity. J Immunol. 2011;187:5548-57 pubmed publisher
    ..In this study, we characterized LMP2(-/-)/MECL-1(-/-) double-deficient mice and used the well-defined LMP7-selective inhibitor ONX 0914 in these mice to ..
  44. Martinez C, Monaco J. Homology of proteasome subunits to a major histocompatibility complex-linked LMP gene. Nature. 1991;353:664-7 pubmed
    ..These observations suggest that the LMP complex may be responsible for generating peptides from cytoplasmic antigen during antigen processing. ..
  45. Schuld N, Hussong S, Kapphahn R, Lehmann U, Roehrich H, Rageh A, et al. Immunoproteasome deficiency protects in the retina after optic nerve crush. PLoS ONE. 2015;10:e0126768 pubmed publisher
    ..Retinas or retinal pigment epithelial (RPE) cells from wild type (WT) and knockout (KO) mice lacking either one (LMP2) or two (LMP7 and MECL-1) catalytic subunits of the immunoproteasome were utilized in this study...
  46. Zanker D, Waithman J, Yewdell J, Chen W. Mixed proteasomes function to increase viral peptide diversity and broaden antiviral CD8+ T cell responses. J Immunol. 2013;191:52-9 pubmed publisher
    ..These findings indicate that mixed proteasomes function to enhance the diversity of peptides and support a broad CD8(+) T cell response. ..
  47. Kishi F, Suminami Y, Monaco J. Genomic organization of the mouse Lmp-2 gene and characteristic structure of its promoter. Gene. 1993;133:243-8 pubmed
    ..The Lmp-2 sequence from a non-obese diabetic (NOD) mouse, a model animal for autoimmune diabetes, was compared with that from a Balb/c mouse. ..
  48. Kasahara M, Hayashi M, Tanaka K, Inoko H, Sugaya K, Ikemura T, et al. Chromosomal localization of the proteasome Z subunit gene reveals an ancient chromosomal duplication involving the major histocompatibility complex. Proc Natl Acad Sci U S A. 1996;93:9096-101 pubmed
    ..3 and 9q33-q34). These observations have implications in understanding the genomic organization of the present-day MHC and offer insights into the origin of the MHC. ..
  49. White L, Wright K, Felix N, Ruffner H, Reis L, Pine R, et al. Regulation of LMP2 and TAP1 genes by IRF-1 explains the paucity of CD8+ T cells in IRF-1-/- mice. Immunity. 1996;5:365-76 pubmed
    The TAP1 and LMP2 genes are central for class I MHC function and share a common promoter. Here, we analyze the molecular mechanism of IFN gamma up-regulation of TAP1 and LMP2...
  50. Chapatte L, Ayyoub M, Morel S, Peitrequin A, Lévy N, Servis C, et al. Processing of tumor-associated antigen by the proteasomes of dendritic cells controls in vivo T-cell responses. Cancer Res. 2006;66:5461-8 pubmed
    ..These results suggest that the inefficient processing of self-antigens, such as Melan-A, by the immunoproteasomes of professional antigen-presenting cells prevents the induction of antitumor T-cell responses in vivo. ..
  51. Hayashi T, Horiuchi A, Sano K, Hiraoka N, Kasai M, Ichimura T, et al. Potential role of LMP2 as tumor-suppressor defines new targets for uterine leiomyosarcoma therapy. Sci Rep. 2011;1:180 pubmed publisher
    ..We earlier reported that mice with a homozygous deficiency for LMP2, an interferon (IFN)-?-inducible factor, spontaneously develop uterine LMS...
  52. Guillon H, Baudat F, Grey C, Liskay R, de Massy B. Crossover and noncrossover pathways in mouse meiosis. Mol Cell. 2005;20:563-73 pubmed
    ..We have developed a strategy to detect, quantify, and map NCRs in parallel to CRs, at the Psmb9 meiotic recombination hot spot, in male and female mouse germ lines...
  53. Robek M, Garcia M, Boyd B, Chisari F. Role of immunoproteasome catalytic subunits in the immune response to hepatitis B virus. J Virol. 2007;81:483-91 pubmed
    ..The immunoproteasome catalytic subunits LMP2 and LMP7 alter proteasome specificity and influence the pool of peptides available for presentation by major ..
  54. Reis J, Hassan F, Guan X, Shen J, Monaco J, Papasian C, et al. The immunoproteasomes regulate LPS-induced TRIF/TRAM signaling pathway in murine macrophages. Cell Biochem Biophys. 2011;60:119-26 pubmed publisher
    ..Accordingly, thioglycollate-elicited macrophages from LMP7, LMP2, LMP10 (MECL-1), and LMP7/MECL-1 double knockout mice were stimulated in vitro with LPS, and were found to generate ..
  55. Zhou P, Cao H, Smart M, David C. Molecular basis of genetic polymorphism in major histocompatibility complex-linked proteasome gene (Lmp-2). Proc Natl Acad Sci U S A. 1993;90:2681-4 pubmed
    ..Allelic polymorphism of the Lmp-2 gene may be involved in peptide selection, leading to autoimmune disease susceptibility. ..
  56. Kremer M, Henn A, Kolb C, Basler M, Moebius J, Guillaume B, et al. Reduced immunoproteasome formation and accumulation of immunoproteasomal precursors in the brains of lymphocytic choriomeningitis virus-infected mice. J Immunol. 2010;185:5549-60 pubmed publisher
  57. Momburg F, Roelse J, Howard J, Butcher G, Hammerling G, Neefjes J. Selectivity of MHC-encoded peptide transporters from human, mouse and rat. Nature. 1994;367:648-51 pubmed
    ..This pattern correlates with the predominant peptide binding profiles of mouse and human class I molecules...
  58. Fruh K, Gossen M, Wang K, Bujard H, Peterson P, Yang Y. Displacement of housekeeping proteasome subunits by MHC-encoded LMPs: a newly discovered mechanism for modulating the multicatalytic proteinase complex. EMBO J. 1994;13:3236-44 pubmed
    ..Thereby two subunits, LMP2 and LMP7, which are encoded in the MHC class II region, are incorporated into the proteasomal complex, whereas ..