Gene Symbol: Psmb11
Description: proteasome (prosome, macropain) subunit, beta type, 11
Alias: 5830406J20Rik, beta5t, proteasome subunit beta type-11, proteasome beta 11 subunit, proteasome subunit beta-5t, proteasome subunit beta5t
Species: mouse
Products:     Psmb11

Top Publications

  1. Murata S, Sasaki K, Kishimoto T, Niwa S, Hayashi H, Takahama Y, et al. Regulation of CD8+ T cell development by thymus-specific proteasomes. Science. 2007;316:1349-53 pubmed
    ..Here, we report the identification of a previously unrecognized catalytic subunit called beta5t. beta5t is expressed exclusively in cortical thymic epithelial cells, which are responsible for the positive ..
  2. Ripen A, Nitta T, Murata S, Tanaka K, Takahama Y. Ontogeny of thymic cortical epithelial cells expressing the thymoproteasome subunit ?5t. Eur J Immunol. 2011;41:1278-87 pubmed publisher
    ..These results indicate that ?5t expression in cTECs is dependent on Foxn1 but independent of thymocyte crosstalk or thymic medulla formation. ..
  3. Žuklys S, Handel A, Zhanybekova S, Govani F, Keller M, Maio S, et al. Foxn1 regulates key target genes essential for T cell development in postnatal thymic epithelial cells. Nat Immunol. 2016;17:1206-1215 pubmed publisher
    ..Thus, critical events in thymic lympho-stromal cross-talk and T cell selection are indispensably choreographed by Foxn1. ..
  4. Nakagawa Y, Ohigashi I, Nitta T, Sakata M, Tanaka K, Murata S, et al. Thymic nurse cells provide microenvironment for secondary T cell receptor ? rearrangement in cortical thymocytes. Proc Natl Acad Sci U S A. 2012;109:20572-7 pubmed publisher
    ..Thus, TNC complexes are formed in vivo by persistent cTEC-thymocyte interactions that then provide a microenvironment that optimizes T-cell selection through secondary TCR rearrangement. ..
  5. Ohigashi I, Zuklys S, Sakata M, Mayer C, Zhanybekova S, Murata S, et al. Aire-expressing thymic medullary epithelial cells originate from ?5t-expressing progenitor cells. Proc Natl Acad Sci U S A. 2013;110:9885-90 pubmed publisher
    ..These results indicate that the majority of mTECs, including autoimmune regulator-expressing mTECs, are derived from ?5t-expressing progenitor cells...
  6. Ando R, Noda K, Tomaru U, Kamoshita M, Ozawa Y, Notomi S, et al. Decreased proteasomal activity causes photoreceptor degeneration in mice. Invest Ophthalmol Vis Sci. 2014;55:4682-90 pubmed publisher
    ..The current data showed that impaired proteasomal function causes photoreceptor degeneration. ..
  7. Nitta T, Muro R, Shimizu Y, Nitta S, Oda H, Ohte Y, et al. The thymic cortical epithelium determines the TCR repertoire of IL-17-producing γδT cells. EMBO Rep. 2015;16:638-53 pubmed publisher
    ..These findings show that cTECs contribute to the shaping of the TCR repertoire, not only of "conventional" αβT cells but also of inflammatory "innate" γδT cells. ..
  8. Takada K, Van Laethem F, Xing Y, Akane K, Suzuki H, Murata S, et al. TCR affinity for thymoproteasome-dependent positively selecting peptides conditions antigen responsiveness in CD8(+) T cells. Nat Immunol. 2015;16:1069-76 pubmed publisher
  9. Uddin M, Ohigashi I, Motosugi R, Nakayama T, Sakata M, Hamazaki J, et al. Foxn1-β5t transcriptional axis controls CD8+ T-cell production in the thymus. Nat Commun. 2017;8:14419 pubmed publisher
    ..The results reveal a Foxn1-β5t transcriptional axis that governs CD8+ T-cell production in the thymus. ..

More Information


  1. Heinonen K, Vanegas J, Brochu S, Shan J, Vainio S, Perreault C. Wnt4 regulates thymic cellularity through the expansion of thymic epithelial cells and early thymic progenitors. Blood. 2011;118:5163-73 pubmed publisher
    ..Wnt4 and its downstream signaling pathways could thus represent interesting candidates to improve thymic output in subjects with thymic atrophy. ..
  2. Nowell C, Bredenkamp N, Tételin S, Jin X, Tischner C, Vaidya H, et al. Foxn1 regulates lineage progression in cortical and medullary thymic epithelial cells but is dispensable for medullary sublineage divergence. PLoS Genet. 2011;7:e1002348 pubmed publisher
    ..Our novel revertible hypomorph system may be similarly applied to analyzing other regulators of development. ..
  3. Xing Y, Jameson S, Hogquist K. Thymoproteasome subunit-?5T generates peptide-MHC complexes specialized for positive selection. Proc Natl Acad Sci U S A. 2013;110:6979-84 pubmed publisher
    ..Altogether, our results suggest that the thymoproteasome supports positive selection by generating peptides that are optimized for the selection of weakly self-reactive, naïve T-cell clones. ..
  4. Sasaki K, Takada K, Ohte Y, Kondo H, Sorimachi H, Tanaka K, et al. Thymoproteasomes produce unique peptide motifs for positive selection of CD8(+) T cells. Nat Commun. 2015;6:7484 pubmed publisher
    ..These results suggest that tCPs contribute to the positive selection of CD8(+) T cells by preferentially producing low-affinity TCR ligand peptides. ..
  5. Ohigashi I, Zuklys S, Sakata M, Mayer C, Hamazaki Y, Minato N, et al. Adult Thymic Medullary Epithelium Is Maintained and Regenerated by Lineage-Restricted Cells Rather Than Bipotent Progenitors. Cell Rep. 2015;13:1432-1443 pubmed publisher
    ..These results indicate that the adult thymic medullary epithelium is maintained and regenerated by mTEC-lineage cells that pass beyond the bipotent stage during early ontogeny. ..
  6. Nitta T, Murata S, Sasaki K, Fujii H, Ripen A, Ishimaru N, et al. Thymoproteasome shapes immunocompetent repertoire of CD8+ T cells. Immunity. 2010;32:29-40 pubmed publisher
    ..These results demonstrate that thymoproteasome-dependent self-peptide production is required for the development of an immunocompetent repertoire of CD8+ T cells. ..
  7. Reeh K, Cardenas K, Bain V, Liu Z, LAURENT M, Manley N, et al. Ectopic TBX1 suppresses thymic epithelial cell differentiation and proliferation during thymus organogenesis. Development. 2014;141:2950-8 pubmed publisher
    ..The results support the hypothesis that Tbx1 negatively regulates TEC growth and differentiation, and that extinction of Tbx1 expression in 3rd pp endoderm is a prerequisite for thymus organogenesis. ..