Psip1

Summary

Gene Symbol: Psip1
Description: PC4 and SFRS1 interacting protein 1
Alias: AA408851, AU015605, Dfs70, Ledgfa, Ledgfb, Psip2, PC4 and SFRS1-interacting protein, PC4 and SFRS1 interacting protein 2, dense fine speckles 70, lens epithelium-derived growth factor
Species: mouse
Products:     Psip1

Top Publications

  1. Sutherland H, Newton K, Brownstein D, Holmes M, Kress C, Semple C, et al. Disruption of Ledgf/Psip1 results in perinatal mortality and homeotic skeletal transformations. Mol Cell Biol. 2006;26:7201-10 pubmed
    PC4- and SF2-interacting protein 1 (Psip1)-also known as lens epithelium-derived growth factor (Ledgf)-is a chromatin-associated protein that has been implicated in transcriptional regulation, mRNA splicing, and cell survival in vitro, ..
  2. Shun M, Raghavendra N, Vandegraaff N, Daigle J, Hughes S, Kellam P, et al. LEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integration. Genes Dev. 2007;21:1767-78 pubmed
    ..Akin to yeast retrotransposons, disrupting the lentiviral targeting mechanism significantly perturbs overall integration. ..
  3. Sharma P, Singh D, Fatma N, Chylack L, Shinohara T. Activation of LEDGF gene by thermal-and oxidative-stresses. Biochem Biophys Res Commun. 2000;276:1320-4 pubmed
    ..Thus, one of the primary events in the stress-related protective events is the activation of LEDGF, a regulatory protein. ..
  4. Takamura Y, Fatma N, Kubo E, Singh D. Regulation of heavy subunit chain of gamma-glutamylcysteine synthetase by tumor necrosis factor-alpha in lens epithelial cells: role of LEDGF/p75. Am J Physiol Cell Physiol. 2006;290:C554-66 pubmed
  5. Pradeepa M, Sutherland H, Ule J, Grimes G, Bickmore W. Psip1/Ledgf p52 binds methylated histone H3K36 and splicing factors and contributes to the regulation of alternative splicing. PLoS Genet. 2012;8:e1002717 pubmed publisher
    ..Here we demonstrate that the PWWP domain of the chromatin-associated protein Psip1/Ledgf can specifically recognize tri-methylated H3K36 and that, like this histone modification, the Psip1 short (..
  6. Méreau H, De Rijck J, Cermakova K, Kutz A, Juge S, Demeulemeester J, et al. Impairing MLL-fusion gene-mediated transformation by dissecting critical interactions with the lens epithelium-derived growth factor (LEDGF/p75). Leukemia. 2013;27:1245-53 pubmed publisher
    ..We conclude that small peptides disrupting the LEDGF/p75-MLL interface have selective anti-leukemic activity providing a direct rationale for the design of small molecule inhibitors targeting this interaction. ..
  7. Crawford Parks T, Ravel Chapuis A, Bondy Chorney E, Renaud J, Cote J, Jasmin B. Muscle-specific expression of the RNA-binding protein Staufen1 induces progressive skeletal muscle atrophy via regulation of phosphatase tensin homolog. Hum Mol Genet. 2017;26:1821-1838 pubmed publisher
    ..Collectively, our data demonstrate that Staufen1 is a novel atrophy-associated gene, and highlight its potential as a biomarker and therapeutic target for neuromuscular disorders and conditions. ..
  8. Fatma N, Kubo E, Chylack L, Shinohara T, Akagi Y, Singh D. LEDGF regulation of alcohol and aldehyde dehydrogenases in lens epithelial cells: stimulation of retinoic acid production and protection from ethanol toxicity. Am J Physiol Cell Physiol. 2004;287:C508-16 pubmed
    ..The present findings indicate that LEDGF is one of the transcriptional activators of these genes that facilitates cellular protection against ethanol stress and plays a role in RA production. ..
  9. Ferris A, Wu X, Hughes C, Stewart C, Smith S, Milne T, et al. Lens epithelium-derived growth factor fusion proteins redirect HIV-1 DNA integration. Proc Natl Acad Sci U S A. 2010;107:3135-40 pubmed publisher
    ..The ability to redirect HIV-1 DNA integration may help solve the problems associated with the activation of oncogenes when retroviruses are used in gene therapy. ..

More Information

Publications15

  1. Roberts J, Ennajdaoui H, Edmondson C, Wirth B, Sanford J, Chen B. Splicing factor TRA2B is required for neural progenitor survival. J Comp Neurol. 2014;522:372-92 pubmed publisher
    ..Thus, TRA2B is essential for proper development of the cerebral cortex. ..
  2. Hasegawa K, Sin H, Maezawa S, Broering T, Kartashov A, Alavattam K, et al. SCML2 establishes the male germline epigenome through regulation of histone H2A ubiquitination. Dev Cell. 2015;32:574-88 pubmed publisher
    ..Our results reveal divergent mechanisms involving a shared regulator by which the male germline epigenome is distinguished from that of the soma and progenitor cells. ..
  3. Bizzaro N, Tonutti E, Visentini D, Alessio M, Platzgummer S, Morozzi G, et al. Antibodies to the lens and cornea in anti-DFS70-positive subjects. Ann N Y Acad Sci. 2007;1107:174-83 pubmed
    Autoantibodies against DFS70 (dense fine speckles 70) antigen have recently been identified among antinuclear antibodies (ANA) in patients with various inflammatory diseases and in patients with different types of cancer...
  4. Wang H, Shun M, Dickson A, ENGELMAN A. Embryonic Lethality Due to Arrested Cardiac Development in Psip1/Hdgfrp2 Double-Deficient Mice. PLoS ONE. 2015;10:e0137797 pubmed publisher
    ..Knockout of the Psip1 gene, which encodes for LEDGF/p75 and the shorter LEDGF/p52 isoform, was previously shown to cause perinatal ..
  5. Girotto G, Scheffer D, Morgan A, Vozzi D, Rubinato E, Di Stazio M, et al. PSIP1/LEDGF: a new gene likely involved in sensorineural progressive hearing loss. Sci Rep. 2015;5:18568 pubmed publisher
    ..Approximately 30 out of 80 known HHL genes are associated with autosomal dominant forms. Here, we identified PSIP1/LEDGF (isoform p75) as a novel strong candidate gene involved in dominant HHL...
  6. Pradeepa M, McKenna F, Taylor G, Bengani H, Grimes G, Wood A, et al. Psip1/p52 regulates posterior Hoxa genes through activation of lncRNA Hottip. PLoS Genet. 2017;13:e1006677 pubmed publisher
    ..Here we show that the short isoform (p52) of a transcriptional co-activator-PC4 and SF2 interacting protein (Psip1), which is known to be involved in linking transcription to RNA processing, specifically regulates the expression ..