Gene Symbol: Prph
Description: peripherin
Alias: Prph1, peripherin, peripherin 1
Species: mouse
Products:     Prph

Top Publications

  1. Puertas M, Carrillo J, Pastor X, Ampudia R, Planas R, Alba A, et al. Peripherin is a relevant neuroendocrine autoantigen recognized by islet-infiltrating B lymphocytes. J Immunol. 2007;178:6533-9 pubmed
    ..Our results showed that peripherin is the autoantigen recognized by all anti-PNS mAbs, and, therefore, a relevant neuroendocrine autoantigen ..
  2. Foley J, Ley C, Parysek L. The structure of the human peripherin gene (PRPH) and identification of potential regulatory elements. Genomics. 1994;22:456-61 pubmed
    We determined the complete nucleotide sequence of the coding region of the human peripherin gene (PRPH), as well as 742 bp 5' to the cap site and 584 bp 3' to the stop codon, and compared its structure and sequence to the rat and mouse ..
  3. Cariboni A, Davidson K, Dozio E, Memi F, Schwarz Q, Stossi F, et al. VEGF signalling controls GnRH neuron survival via NRP1 independently of KDR and blood vessels. Development. 2011;138:3723-33 pubmed publisher
    ..Thus, the loss of both neuropilin ligands leads to an almost complete failure to establish the GnRH neuron system. ..
  4. Messina A, Ferraris N, Wray S, Cagnoni G, Donohue D, Casoni F, et al. Dysregulation of Semaphorin7A/?1-integrin signaling leads to defective GnRH-1 cell migration, abnormal gonadal development and altered fertility. Hum Mol Genet. 2011;20:4759-74 pubmed publisher
    ..In conclusion, we have identified Sema7A as a gene implicated in the normal development of the GnRH-1 system in mice and as a genetic marker for the elucidation of some forms of GnRH-1 deficiency in humans. ..
  5. Huang L, Thorne P, Housley G, Montgomery J. Spatiotemporal definition of neurite outgrowth, refinement and retraction in the developing mouse cochlea. Development. 2007;134:2925-33 pubmed
    ..b>Peripherin and choline-acetyltransferase immunofluorescence confirmed the type II and efferent innervation patterns, ..
  6. Schwarting G, Raitcheva D, Bless E, Ackerman S, Tobet S. Netrin 1-mediated chemoattraction regulates the migratory pathway of LHRH neurons. Eur J Neurosci. 2004;19:11-20 pubmed
    ..Loss of function through a genetic deletion in either Dcc or Ntn1 results in the migration of many LHRH neurons to inappropriate destinations. ..
  7. Landon F, Lemonnier M, Benarous R, Huc C, Fiszman M, Gros F, et al. Multiple mRNAs encode peripherin, a neuronal intermediate filament protein. EMBO J. 1989;8:1719-26 pubmed
    Three cDNA clones of 1.6 (3u), 1.2 (5g) and 0.6 (5b) kbp, specific for peripherin, a neuronal intermediate filament protein (IFP), have been isolated from a murine neuroblastoma cell lambda gt11 library by immunoscreening using peripherin ..
  8. Larivière R, Nguyen M, Ribeiro da Silva A, Julien J. Reduced number of unmyelinated sensory axons in peripherin null mice. J Neurochem. 2002;81:525-32 pubmed
    b>Peripherin is a type III intermediate filament (IF) abundantly expressed in developing neurons, but in the adult, it is primarily found in neurons extending to the peripheral nervous system...
  9. Schwarting G, Kostek C, Bless E, Ahmad N, Tobet S. Deleted in colorectal cancer (DCC) regulates the migration of luteinizing hormone-releasing hormone neurons to the basal forebrain. J Neurosci. 2001;21:911-9 pubmed
    ..Loss of DCC function results in the migration of many LHRH neurons to inappropriate destinations. ..

More Information


  1. Madison B, Braunstein K, Kuizon E, Portman K, Qiao X, Gumucio D. Epithelial hedgehog signals pattern the intestinal crypt-villus axis. Development. 2005;132:279-89 pubmed
    ..Thus, through a combined Hh signal to underlying ISEMFs, the epithelium patterns the crypt-villus axis, ensuring the proper size and location of the emerging precrypt compartment. ..
  2. Mandai K, Guo T, St Hillaire C, Meabon J, Kanning K, Bothwell M, et al. LIG family receptor tyrosine kinase-associated proteins modulate growth factor signals during neural development. Neuron. 2009;63:614-27 pubmed publisher
    ..These findings show that LIGs physically interact with RTKs and modulate their activities to control axonal extension, guidance and branching. ..
  3. Cariboni A, Davidson K, Rakic S, Maggi R, Parnavelas J, Ruhrberg C. Defective gonadotropin-releasing hormone neuron migration in mice lacking SEMA3A signalling through NRP1 and NRP2: implications for the aetiology of hypogonadotropic hypogonadism. Hum Mol Genet. 2011;20:336-44 pubmed publisher
  4. Beaulieu J, Nguyen M, Julien J. Late onset of motor neurons in mice overexpressing wild-type peripherin. J Cell Biol. 1999;147:531-44 pubmed
    b>Peripherin, a type III intermediate filament (IF) protein, upregulated by injury and inflammatory cytokines, is a component of IF inclusion bodies associated with degenerating motor neurons in sporadic amyotrophic lateral sclerosis (ALS)...
  5. Kriz J, Beaulieu J, Julien J, Krnjevic K. Up-regulation of peripherin is associated with alterations in synaptic plasticity in CA1 and CA3 regions of hippocampus. Neurobiol Dis. 2005;18:409-20 pubmed
    b>Peripherin is a type III intermediate filament protein normally undetectable in most brain neurons...
  6. Barclay M, Noakes P, Ryan A, Julien J, Housley G. Neuronal expression of peripherin, a type III intermediate filament protein, in the mouse hindbrain. Histochem Cell Biol. 2007;128:541-50 pubmed
    b>Peripherin is a 57 kDa Type III intermediate filament protein associated with neurite extension, neuropathies such as amyotrophic lateral sclerosis, and cranial nerve and dorsal root projections...
  7. Luo W, Wickramasinghe S, Savitt J, Griffin J, Dawson T, Ginty D. A hierarchical NGF signaling cascade controls Ret-dependent and Ret-independent events during development of nonpeptidergic DRG neurons. Neuron. 2007;54:739-54 pubmed
    ..These findings support a model in which NGF controls maturation of nonpeptidergic DRG neurons through a combination of GFR/Ret-dependent and -independent signaling pathways. ..
  8. Kramer P, Wray S. Midline nasal tissue influences nestin expression in nasal-placode-derived luteinizing hormone-releasing hormone neurons during development. Dev Biol. 2000;227:343-57 pubmed
    ..Prolonged nestin expression in LHRH cells after midline removal is consistent with nasal midline tissues modulating differentiation of LHRH neurons from the nasal placode. ..
  9. Coppola E, Rallu M, Richard J, Dufour S, Riethmacher D, Guillemot F, et al. Epibranchial ganglia orchestrate the development of the cranial neurogenic crest. Proc Natl Acad Sci U S A. 2010;107:2066-71 pubmed publisher
  10. Bachy I, Franck M, Li L, Abdo H, Pattyn A, Ernfors P. The transcription factor Cux2 marks development of an A-delta sublineage of TrkA sensory neurons. Dev Biol. 2011;360:77-86 pubmed publisher
    ..Hence, our results show that Cux2 is expressed and may participate in development of a specific subtype of myelinated TrkA(+) nociceptors. ..
  11. Nour M, Fliesler S, Naash M. Genetic supplementation of RDS alleviates a loss-of-function phenotype in C214S model of retinitis pigmentosa. Adv Exp Med Biol. 2008;613:129-38 pubmed publisher
  12. Colucci D Amato G, Tino A, Pernas Alonso R, Ffrench Mullen J, di Porzio U. Neuronal and glial properties coexist in a novel mouse CNS immortalized cell line. Exp Cell Res. 1999;252:383-91 pubmed
    ..precursor, and show neuronal markers such as microtubule-associated protein 1, neuron-specific enolase and peripherin, and the glial marker glial fibrillary acidic protein. Neuronal and glial markers coexist in single cells...
  13. Udager A, Prakash A, Saenz D, Schinke M, Moriguchi T, Jay P, et al. Proper development of the outer longitudinal smooth muscle of the mouse pylorus requires Nkx2-5 and Gata3. Gastroenterology. 2014;146:157-165.e10 pubmed publisher
    ..These data indicate that regulatory changes that alter Nkx2-5 or Gata3 expression could contribute to pathogenesis of infantile hypertrophic pyloric stenosis. ..
  14. Couesnon A, Offner N, Bernard V, Chaverot N, Backer S, Dimitrov A, et al. CLIPR-59: a protein essential for neuromuscular junction stability during mouse late embryonic development. Development. 2013;140:1583-93 pubmed publisher
    ..Thus, CLIPR-59 is involved in the stabilization of specific motor axons at the NMJ during mouse late embryogenesis and its role is crucial for mouse perinatal development. ..
  15. Karpov V, Fauquet M, Lecomte M, Portier M. Three different states of the chromatin structure of the mouse peripherin gene. J Neurosci Res. 1996;44:115-23 pubmed
    The chromatin structure of the mouse peripherin gene domain was analyzed in peripherin-positive and -negative cell lines...
  16. Caubit X, Thoby Brisson M, Voituron N, Filippi P, Bevengut M, Faralli H, et al. Teashirt 3 regulates development of neurons involved in both respiratory rhythm and airflow control. J Neurosci. 2010;30:9465-76 pubmed publisher
    ..Thus, a single gene, Tshz3, controls the development of diverse components of the circuitry required for breathing. ..
  17. Lee J, Tiong J, Maddox D, Condie B, Wray S. Temporal migration of gonadotrophin-releasing hormone-1 neurones is modified in GAD67 knockout mice. J Neuroendocrinol. 2008;20:93-103 pubmed
    ..These data indicate that attenuated levels of GABA accelerate GnRH-1 cell migration in nasal areas as well as movement of GnRH-1 cells into the central nervous system at the NFJ. ..
  18. Usui N, Watanabe K, Ono K, Tomita K, Tamamaki N, Ikenaka K, et al. Role of motoneuron-derived neurotrophin 3 in survival and axonal projection of sensory neurons during neural circuit formation. Development. 2012;139:1125-32 pubmed publisher
    ..Taken together, we show that the motoneuron is a functional source of Ntf3 and motoneuron-derived Ntf3 is an essential pre-target neurotrophin for survival and axonal projection of sensory neurons. ..
  19. Hong S, Lardaro T, Oh M, Huh Y, Ding Y, Kang U, et al. Regulation of the noradrenaline neurotransmitter phenotype by the transcription factor AP-2beta. J Biol Chem. 2008;283:16860-7 pubmed publisher
    ..In summary, we propose that AP-2beta plays critical and distinctive roles in the NA phenotype specification in both the peripheral and central nervous system during development. ..
  20. Carrillo J, Puertas M, Planas R, Pastor X, Alba A, Stratmann T, et al. Anti-peripherin B lymphocytes are positively selected during diabetogenesis. Mol Immunol. 2008;45:3152-62 pubmed publisher
    ..We found that a sizable proportion of hybridomas produced monoclonal antibodies reactive to peripherin, an intermediate filament protein mainly found in the peripheral nervous system...
  21. Barclay M, Julien J, Ryan A, Housley G. Type III intermediate filament peripherin inhibits neuritogenesis in type II spiral ganglion neurons in vitro. Neurosci Lett. 2010;478:51-5 pubmed publisher
    b>Peripherin, a type III intermediate filament protein, forms part of the cytoskeleton in a subset of neurons, most of which have peripheral fibre projections...
  22. Dykes I, Tempest L, Lee S, Turner E. Brn3a and Islet1 act epistatically to regulate the gene expression program of sensory differentiation. J Neurosci. 2011;31:9789-99 pubmed publisher
  23. Marcos S, Monnier C, Rovira X, Fouveaut C, Pitteloud N, Ango F, et al. Defective signaling through plexin-A1 compromises the development of the peripheral olfactory system and neuroendocrine reproductive axis in mice. Hum Mol Genet. 2017;26:2006-2017 pubmed publisher
    ..Our findings indicate that signaling insufficiency through plexin-A1 can contribute to the pathogenesis of Kallmann syndrome, and further substantiate the oligogenic pattern of inheritance in this developmental disorder. ..
  24. Walter L, Marynen P, Szpirer J, Levan G, Gunther E. Identification of a novel conserved human gene, TEGT. Genomics. 1995;28:301-4 pubmed
    ..The presence of a nuclear targeting motif indicates that the gene product might localize to the nucleus. The TEGT gene maps to human chromosome 12q12-q13 and belongs to a syntenic group, which is conserved in human, mouse, and rat. ..
  25. Rao M, Engle L, Mohan P, Yuan A, Qiu D, Cataldo A, et al. Myosin Va binding to neurofilaments is essential for correct myosin Va distribution and transport and neurofilament density. J Cell Biol. 2002;159:279-90 pubmed
  26. Hartman B, Nelson B, Reh T, Bermingham McDonogh O. Delta/notch-like EGF-related receptor (DNER) is expressed in hair cells and neurons in the developing and adult mouse inner ear. J Assoc Res Otolaryngol. 2010;11:187-201 pubmed publisher
    ..We found no defects in expression of markers of supporting cells and glia or myelin, and no abnormalities in hair cells or neurons, suggesting that DNER plays a redundant role with other Notch ligands in cochlear development. ..
  27. Rattazzi L, Cariboni A, Poojara R, Shoenfeld Y, D Acquisto F. Impaired sense of smell and altered olfactory system in RAG-1(-∕-) immunodeficient mice. Front Neurosci. 2015;9:318 pubmed publisher
    ..Together these findings provide a formerly unreported biological evidence for an altered function of the olfactory system in RAG-1 (-∕-) mice. ..
  28. Lariviere R, Beaulieu J, Nguyen M, Julien J. Peripherin is not a contributing factor to motor neuron disease in a mouse model of amyotrophic lateral sclerosis caused by mutant superoxide dismutase. Neurobiol Dis. 2003;13:158-66 pubmed
    b>Peripherin is a type III intermediate filament protein detected in axonal spheroids associated with amyotrophic lateral sclerosis (ALS)...
  29. Ohshima T, Ogawa M, Takeuchi K, Takahashi S, Kulkarni A, Mikoshiba K. Cyclin-dependent kinase 5/p35 contributes synergistically with Reelin/Dab1 to the positioning of facial branchiomotor and inferior olive neurons in the developing mouse hindbrain. J Neurosci. 2002;22:4036-44 pubmed
    ..These results indicate that Cdk5/p35 and Reelin signaling regulates the selective mode of neuronal migration in the developing mouse hindbrain. ..
  30. Zhao X, Zhang H, Guo J, Zhang Y. The effects of bilateral common carotid artery occlusion on expression of peripherin and choline acetyltransferase activity in C57BL/6 mice. Brain Res. 2013;1491:167-75 pubmed publisher
    b>Peripherin is a 57-kDa type III neuronal intermediate filament protein that appears to play a role in neurite elongation during development and axonal regeneration...
  31. Li W, Mukouyama Y. Tissue-specific venous expression of the EPH family receptor EphB1 in the skin vasculature. Dev Dyn. 2013;242:976-88 pubmed publisher
    ..These studies introduce EphB1 as a new venous-restricted marker in a tissue-specific and time-dependent manner. ..
  32. Cariboni A, André V, Chauvet S, Cassatella D, Davidson K, Caramello A, et al. Dysfunctional SEMA3E signaling underlies gonadotropin-releasing hormone neuron deficiency in Kallmann syndrome. J Clin Invest. 2015;125:2413-28 pubmed publisher
  33. Parisi M, Baldessari A, Iida M, Clarke C, Doggett B, Shirasawa S, et al. Genetic background modifies intestinal pseudo-obstruction and the expression of a reporter gene in Hox11L1-/- mice. Gastroenterology. 2003;125:1428-40 pubmed
    ..Expression of the transgene by enteric neurons and penetrance of pseudo-obstruction in Hox11L1-null animals are influenced by one or more modifier genes, counterparts of which may play a similar role in human disease. ..
  34. Chen Z, Donnelly C, Dominguez B, Harada Y, Lin W, Halim A, et al. p75 Is Required for the Establishment of Postnatal Sensory Neuron Diversity by Potentiating Ret Signaling. Cell Rep. 2017;21:707-720 pubmed publisher
    ..These results suggest that p75 is required for the development of the nonpeptidergic nociceptor lineage by fine-tuning Ret-mediated trophic support. ..
  35. Maison S, Liberman L, Liberman M. Type II Cochlear Ganglion Neurons Do Not Drive the Olivocochlear Reflex: Re-Examination of the Cochlear Phenotype in Peripherin Knock-Out Mice. Eneuro. 2016;3: pubmed publisher
    ..A recent study (Froud et al., 2015) reported that targeted deletion of peripherin, a type of neurofilament, eliminated type II afferents and inactivated efferent feedback to the outer hair cells,..
  36. Nagashimada M, Ohta H, Li C, Nakao K, Uesaka T, Brunet J, et al. Autonomic neurocristopathy-associated mutations in PHOX2B dysregulate Sox10 expression. J Clin Invest. 2012;122:3145-58 pubmed publisher
    ..Our results also demonstrate that Sox10 regulation by PHOX2B is pivotal for the development and pathogenesis of the autonomic ganglia. ..
  37. Kramer P, Wray S. Novel gene expressed in nasal region influences outgrowth of olfactory axons and migration of luteinizing hormone-releasing hormone (LHRH) neurons. Genes Dev. 2000;14:1824-34 pubmed
    ..These results demonstrate that NELF plays a role as a common guidance molecule for olfactory axon projections and subsequently, either directly or indirectly, in the neurophilic migration of LHRH cells. ..
  38. Garabatos N, Alvarez R, Carrillo J, Carrascal J, Izquierdo C, Chapman H, et al. In vivo detection of peripherin-specific autoreactive B cells during type 1 diabetes pathogenesis. J Immunol. 2014;192:3080-90 pubmed publisher
    ..In this study, we analyzed the immune response in the NOD mouse model to the neuronal protein peripherin (PRPH), a target Ag of islet-infiltrating B cells...
  39. Meziane H, Fraulob V, Riet F, Krezel W, Selloum M, Geffarth M, et al. The homeodomain factor Gbx1 is required for locomotion and cell specification in the dorsal spinal cord. Peerj. 2013;1:e142 pubmed publisher
    ..Our study unveiled a role for Gbx1 in specifying a subset of GABAergic neurons in the dorsal horn of the spinal cord involved in the control of posterior limb movement. ..
  40. Eriksson K, Zhang S, Lin L, Lariviere R, Julien J, Mignot E. The type III neurofilament peripherin is expressed in the tuberomammillary neurons of the mouse. BMC Neurosci. 2008;9:26 pubmed publisher
    b>Peripherin, a type III neuronal intermediate filament, is widely expressed in neurons of the peripheral nervous system and in selected central nervous system hindbrain areas with projections towards peripheral structures, such as cranial ..
  41. Durbec P, Larsson Blomberg L, Schuchardt A, Costantini F, Pachnis V. Common origin and developmental dependence on c-ret of subsets of enteric and sympathetic neuroblasts. Development. 1996;122:349-58 pubmed
    ..Overall, our studies reveal previously unknown complexities of cell lineage and genetic control mechanisms in the developing mammalian peripheral nervous system. ..
  42. Leconte L, Santha M, Fort C, Poujeol C, Portier M, Simonneau M. Cell type-specific expression of the mouse peripherin gene requires both upstream and intragenic sequences in transgenic mouse embryos. Brain Res Dev Brain Res. 1996;92:1-9 pubmed
    b>Peripherin is a neuron-specific type III intermediate filament protein expressed in well-defined populations of neurons projecting towards peripheral targets...
  43. Hirsch M, Tiveron M, Guillemot F, Brunet J, Goridis C. Control of noradrenergic differentiation and Phox2a expression by MASH1 in the central and peripheral nervous system. Development. 1998;125:599-608 pubmed
  44. Memi F, Abe P, Cariboni A, Mackay F, Parnavelas J, Stumm R. CXC chemokine receptor 7 (CXCR7) affects the migration of GnRH neurons by regulating CXCL12 availability. J Neurosci. 2013;33:17527-37 pubmed publisher
    ..These findings imply that CXCR7 regulates CXCL12 availability by acting as a scavenger along the migratory path of GnRH neurons and, thus, influences the migration of these cells in a noncell-autonomous manner. ..
  45. Quina L, Tempest L, Hsu Y, Cox T, Turner E. Hmx1 is required for the normal development of somatosensory neurons in the geniculate ganglion. Dev Biol. 2012;365:152-63 pubmed
    ..Fate mapping of neural crest-derived tissues indicates that Hmx1-expressing somatosensory neurons at different axial levels may be derived from either the neural crest or the neurogenic placodes. ..
  46. Zou M, Li S, Klein W, Xiang M. Brn3a/Pou4f1 regulates dorsal root ganglion sensory neuron specification and axonal projection into the spinal cord. Dev Biol. 2012;364:114-27 pubmed publisher
    ..Our results together demonstrate a critical role for Brn3a in generating DRG sensory neuron diversity and regulating sensory afferent projections to the central targets. ..
  47. Kajimura D, Dragomir C, Ramirez F, Laub F. Identification of genes regulated by transcription factor KLF7 in differentiating olfactory sensory neurons. Gene. 2007;388:34-42 pubmed
    ..Collectively, these results advance knowledge of transcriptional regulation of olfactory neurogenesis and KLF7 action. ..
  48. Coppola E, D Autréaux F, Rijli F, Brunet J. Ongoing roles of Phox2 homeodomain transcription factors during neuronal differentiation. Development. 2010;137:4211-20 pubmed publisher
  49. Lek M, Dias J, Marklund U, Uhde C, Kurdija S, Lei Q, et al. A homeodomain feedback circuit underlies step-function interpretation of a Shh morphogen gradient during ventral neural patterning. Development. 2010;137:4051-60 pubmed publisher
    ..These data establish that dynamic, non-graded changes in responding cells are essential for Shh morphogen interpretation, and provide a rationale to explain mechanistically the phenomenon of cellular memory of morphogen exposure. ..
  50. Schmidt H, Stonkute A, Jüttner R, Schaffer S, Buttgereit J, Feil R, et al. The receptor guanylyl cyclase Npr2 is essential for sensory axon bifurcation within the spinal cord. J Cell Biol. 2007;179:331-40 pubmed
    ..Hence, our data demonstrate that Npr2 and cGKI are essential constituents of the signaling pathway underlying axonal bifurcation at the DREZ and neuronal connectivity in the dorsal spinal cord. ..
  51. McLean J, Liu H, Miletic D, Weng Y, Rogaeva E, Zinman L, et al. Distinct biochemical signatures characterize peripherin isoform expression in both traumatic neuronal injury and motor neuron disease. J Neurochem. 2010;114:1177-92 pubmed publisher
    b>Peripherin is a type III intermediate filament protein that is up-regulated during neuronal injury and is a major component of pathological inclusions found within degenerating motor neurons of patients with amyotrophic lateral sclerosis (..
  52. McLean J, Xiao S, Miyazaki K, Robertson J. A novel peripherin isoform generated by alternative translation is required for normal filament network formation. J Neurochem. 2008;104:1663-73 pubmed publisher
    b>Peripherin is a type III neuronal intermediate filament protein detected within the intraneuronal inclusions characteristic of amyotrophic lateral sclerosis...
  53. Finotto S, Krieglstein K, Schober A, Deimling F, Lindner K, Brühl B, et al. Analysis of mice carrying targeted mutations of the glucocorticoid receptor gene argues against an essential role of glucocorticoid signalling for generating adrenal chromaffin cells. Development. 1999;126:2935-44 pubmed
    ..b>Peripherin, an intermediate filament of sympathetic neurones, is undetectable in chromaffin cells of GR mutants...
  54. Abbott M, Joksimovic M, Tuggle C. Ectopic HOXA5 expression results in abnormal differentiation, migration and p53-independent cell death of superficial dorsal horn neurons. Brain Res Dev Brain Res. 2005;159:87-97 pubmed
    ..Our evidence suggests that the loss of dorsal horn neurons in Hoxa5SV2 mutants was due to misexpression of dorsal horn neuronal markers, aberrant migration, and inappropriate apoptosis. ..
  55. Sonnenberg Riethmacher E, Miehe M, Stolt C, Goerich D, Wegner M, Riethmacher D. Development and degeneration of dorsal root ganglia in the absence of the HMG-domain transcription factor Sox10. Mech Dev. 2001;109:253-65 pubmed
    ..5 and E 11.5). We show that both increased apoptosis as well as decreased proliferation of neural crest cells contribute to the observed hypomorphism. ..
  56. Schmidt H, Stonkute A, Jüttner R, Koesling D, Friebe A, Rathjen F. C-type natriuretic peptide (CNP) is a bifurcation factor for sensory neurons. Proc Natl Acad Sci U S A. 2009;106:16847-52 pubmed publisher
    ..Functionally, the bifurcation error in CNP mutant mice is maintained at mature stages and results in a reduced input on secondary neurons as detected by patch-clamp recordings. ..
  57. Sassone J, Taiana M, Lombardi R, Porretta Serapiglia C, Freschi M, Bonanno S, et al. ALS mouse model SOD1G93A displays early pathology of sensory small fibers associated to accumulation of a neurotoxic splice variant of peripherin. Hum Mol Genet. 2016;25:1588-99 pubmed publisher dorsal root ganglia (DRG), whose biochemical hallmark is the expression of type III intermediate filament peripherin. We tested here the hypothesis that small-diameter DRG neurons of ALS mouse model SOD1(G93A)suffer from axonal ..
  58. Faussone Pellegrini M, Matini P, DeFelici M. The cytoskeleton of the myenteric neurons during murine embryonic life. Anat Embryol (Berl). 1999;199:459-69 pubmed
    ..proteins (the low, NF-L, medium, NF-M, and heavy, NF-H, molecular weight subunits, alpha-internexin and peripherin) and of two of the microtubule-associated proteins (MAPI and MAP2a+2b)...
  59. Enomoto H, Heuckeroth R, Golden J, Johnson E, Milbrandt J. Development of cranial parasympathetic ganglia requires sequential actions of GDNF and neurturin. Development. 2000;127:4877-89 pubmed
  60. Buckley D, Burroughs Garcia J, Lewandoski M, Waters S. Characterization of the Gbx1-/- mouse mutant: a requirement for Gbx1 in normal locomotion and sensorimotor circuit development. PLoS ONE. 2013;8:e56214 pubmed publisher
    ..The generation of this null allele has enabled us to functionally characterize a novel role for Gbx1 in development of the spinal cord. ..
  61. Velkey J, O Shea K. Expression of Neurogenin 1 in mouse embryonic stem cells directs the differentiation of neuronal precursors and identifies unique patterns of down-stream gene expression. Dev Dyn. 2013;242:230-53 pubmed publisher
  62. Yuan A, Sasaki T, Kumar A, Peterhoff C, Rao M, LIEM R, et al. Peripherin is a subunit of peripheral nerve neurofilaments: implications for differential vulnerability of CNS and peripheral nervous system axons. J Neurosci. 2012;32:8501-8 pubmed publisher
    b>Peripherin, a neuronal intermediate filament protein implicated in neurodegenerative disease, coexists with the neurofilament triplet proteins [neurofilament light (NFL), medium (NFM), and heavy (NFH) chain] but has an unknown function...
  63. Banks G, Haas M, Line S, Shepherd H, AlQatari M, Stewart S, et al. Behavioral and other phenotypes in a cytoplasmic Dynein light intermediate chain 1 mutant mouse. J Neurosci. 2011;31:5483-94 pubmed publisher
    ..These results demonstrate the important role that dynein-controlled processes play in the correct development and function of the mammalian nervous system. ..
  64. Dessaud E, Salaün D, Gayet O, Chabbert M, Delapeyrière O. Identification of lynx2, a novel member of the ly-6/neurotoxin superfamily, expressed in neuronal subpopulations during mouse development. Mol Cell Neurosci. 2006;31:232-42 pubmed
    ..Comparison of its spatio-temporal expression pattern with that of two other members of this family, lynx1 and ly-6h, shows that these genes are detected both in distinct and overlapping neuron populations. ..
  65. Sun W, Gould T, Vinsant S, Prevette D, Oppenheim R. Neuromuscular development after the prevention of naturally occurring neuronal death by Bax deletion. J Neurosci. 2003;23:7298-310 pubmed
    ..Although sensory neurons in the dorsal root ganglia are also rescued from PCD by Bax deletion, their subsequent development is less affected than that of MNs. ..
  66. Pernas Alonso R, Schaffner A, Hansen C, Barker J, di Porzio U. Acetylcholine esterase and peripherin mRNA level decrease in wobbler mouse. Neuroreport. 1995;6:597-600 pubmed
    ..Thus, similarly to medium neurofilament gene over-expression, reduced acetylcholinesterase gene expression is an early molecular marker for the wobbler mutation before onset of the illness. ..
  67. Nishimura K, Noda T, Dabdoub A. Dynamic Expression of Sox2, Gata3, and Prox1 during Primary Auditory Neuron Development in the Mammalian Cochlea. PLoS ONE. 2017;12:e0170568 pubmed publisher
    ..Moreover, we describe two subtypes of type II neurons based on Peripherin expression...
  68. Espinosa Medina I, Outin E, Picard C, Chettouh Z, Dymecki S, Consalez G, et al. Neurodevelopment. Parasympathetic ganglia derive from Schwann cell precursors. Science. 2014;345:87-90 pubmed publisher
    ..Thus, cranial Schwann cell precursors are the source of parasympathetic neurons during normal development. ..
  69. Mansouri A, Voss A, Thomas T, Yokota Y, Gruss P. Uncx4.1 is required for the formation of the pedicles and proximal ribs and acts upstream of Pax9. Development. 2000;127:2251-8 pubmed
    ..1 upstream of Pax9 in the caudolateral sclerotome. Our results further indicate that Uncx4.1 may be involved in the differential cell adhesion properties of the somite. ..
  70. Karunadasa D, Chapman C, Bicknell R. Expression of pheromone receptor gene families during olfactory development in the mouse: expression of a V1 receptor in the main olfactory epithelium. Eur J Neurosci. 2006;23:2563-72 pubmed
    ..However, no expression of this gene or of other V1Rs and V2Rs is detectable at the cellular level in migrating GnRH neurons in the mouse...
  71. Albert Y, Whitehead J, Eldredge L, Carter J, Gao X, Tourtellotte W. Transcriptional regulation of myotube fate specification and intrafusal muscle fiber morphogenesis. J Cell Biol. 2005;169:257-68 pubmed
    ..Hence, Egr3 is a target gene that is regulated by sensory innervation and that mediates gene expression involved in myotube fate specification and intrafusal muscle fiber morphogenesis. ..
  72. Rebelo S, Chen Z, Anderson D, Lima D. Involvement of DRG11 in the development of the primary afferent nociceptive system. Mol Cell Neurosci. 2006;33:236-46 pubmed
  73. Pattyn A, Vallstedt A, Dias J, Sander M, Ericson J. Complementary roles for Nkx6 and Nkx2 class proteins in the establishment of motoneuron identity in the hindbrain. Development. 2003;130:4149-59 pubmed
    ..Thus, both visceral and somatic motoneuron differentiation appear to rely on the combined activity of cell intrinsic determinants, rather than on a single key determinant of neuronal cell fate. ..
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