Gene Symbol: Pros1
Description: protein S (alpha)
Alias: AW214361, vitamin K-dependent protein S
Species: mouse
Products:     Pros1

Top Publications

  1. Chu M, Sun J, Bird P. Cloning and sequencing of a cDNA encoding the murine vitamin K-dependent protein S. Biochim Biophys Acta. 1994;1217:325-8 pubmed
    ..Sequencing revealed an open reading frame encoding a 634 amino acid mature protein. Comparison to human and bovine sequences showed a high degree of similarity and the conservation of key residues between the species. ..
  2. Ginisty A, Gély Pernot A, Abaamrane L, Morel F, Arnault P, Coronas V, et al. Evidence for a subventricular zone neural stem cell phagocytic activity stimulated by the vitamin K-dependent factor protein S. Stem Cells. 2015;33:515-25 pubmed publisher
  3. Deng T, Zhang Y, Chen Q, Yan K, Han D. Toll-like receptor-mediated inhibition of Gas6 and ProS expression facilitates inflammatory cytokine production in mouse macrophages. Immunology. 2012;135:40-50 pubmed publisher
    ..These results describe a self-regulatory mechanism of TLR signalling through the suppression of Gas6 and ProS expression. ..
  4. Zelentsova K, Talmi Z, Abboud Jarrous G, Sapir T, Capucha T, Nassar M, et al. Protein S Regulates Neural Stem Cell Quiescence and Neurogenesis. Stem Cells. 2017;35:679-693 pubmed publisher
    ..Here, we report the expression of Protein S (PROS1) in adult NSCs, and show that genetic ablation of Pros1 in neural progenitors increased hippocampal NSC ..
  5. Chan P, Carrera Silva E, de Kouchkovsky D, Joannas L, Hao L, Hu D, et al. The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity. Science. 2016;352:99-103 pubmed publisher
    ..Furthermore, the TYRO3 agonist PROS1 was induced in T cells by the quintessential type 2 cytokine, interleukin-4...
  6. Fernandez J, Heeb M, Xu X, Singh I, Zlokovic B, Griffin J. Species-specific anticoagulant and mitogenic activities of murine protein S. Haematologica. 2009;94:1721-31 pubmed publisher
    ..This study extends previous observations regarding the remarkable species specificity of protein S to the mouse. ..
  7. Burstyn Cohen T, Lew E, Traves P, Burrola P, Hash J, Lemke G. Genetic dissection of TAM receptor-ligand interaction in retinal pigment epithelial cell phagocytosis. Neuron. 2012;76:1123-32 pubmed publisher
    ..These results demonstrate that Protein S and Gas6 function as independent, bona fide Mer ligands, and are, to a first approximation, interchangeable with respect to Mer-driven phagocytosis in the retina. ..
  8. Carrera Silva E, Chan P, Joannas L, Errasti A, Gagliani N, Bosurgi L, et al. T cell-derived protein S engages TAM receptor signaling in dendritic cells to control the magnitude of the immune response. Immunity. 2013;39:160-70 pubmed publisher
    ..T cells, once activated, produced Protein S (Pros1) that signaled through TAM receptor tyrosine kinases in DCs to limit the magnitude of DC activation...
  9. Lew E, Oh J, Burrola P, Lax I, Zagórska A, Través P, et al. Differential TAM receptor-ligand-phospholipid interactions delimit differential TAM bioactivities. elife. 2014;3: pubmed publisher
    ..In two settings of TAM-dependent homeostatic phagocytosis, Mer plays a predominant role while Axl is dispensable, and activation of Mer by Protein S is sufficient to drive phagocytosis. ..

More Information


  1. Tashima Y, Banno F, Kita T, Matsuda Y, Yanamoto H, Miyata T. Plasminogen Tochigi mice exhibit phenotypes similar to wild-type mice under experimental thrombotic conditions. PLoS ONE. 2017;12:e0180981 pubmed publisher
    ..PlgT/T mice can be used to investigate the potential pathophysiological impact of the Plg-A620T mutation. ..
  2. Lu D, Schmidel D, Long G. Structure of mouse protein S as determined by PCR amplification and DNA sequencing of cDNA. Thromb Res. 1994;74:135-42 pubmed
    ..The mouse protein S contains two potential N-glycosylation sites at positions #458 and 468 and is lacking the putative glycosylation site at #490 found in human protein S. ..
  3. Yasuma T, Yano Y, D Alessandro Gabazza C, Toda M, Gil Bernabe P, Kobayashi T, et al. Amelioration of Diabetes by Protein S. Diabetes. 2016;65:1940-51 pubmed publisher
    ..This study shows that protein S attenuates diabetes by inhibiting apoptosis of ?-cells and the development of diabetic nephropathy. ..
  4. Banno F, Kita T, Fernández J, Yanamoto H, Tashima Y, Kokame K, et al. Exacerbated venous thromboembolism in mice carrying a protein S K196E mutation. Blood. 2015;126:2247-53 pubmed publisher
  5. Zhu D, Wang Y, Singh I, Bell R, Deane R, Zhong Z, et al. Protein S controls hypoxic/ischemic blood-brain barrier disruption through the TAM receptor Tyro3 and sphingosine 1-phosphate receptor. Blood. 2010;115:4963-72 pubmed publisher
    ..Our findings indicate that PS protects the BBB integrity via Tyro3 and S1P(1), suggesting potentially novel treatments for neurovascular dysfunction resulting from hypoxic/ischemic BBB damage...
  6. Burstyn Cohen T, Heeb M, Lemke G. Lack of protein S in mice causes embryonic lethal coagulopathy and vascular dysgenesis. J Clin Invest. 2009;119:2942-53 pubmed publisher
    Protein S (ProS) is a blood anticoagulant encoded by the Pros1 gene, and ProS deficiencies are associated with venous thrombosis, stroke, and autoimmunity...
  7. Saller F, Brisset A, Tchaikovski S, Azevedo M, Chrast R, Fernandez J, et al. Generation and phenotypic analysis of protein S-deficient mice. Blood. 2009;114:2307-14 pubmed publisher
    ..5 and the full term. Thus, similar to human phenotypes, mild heterozygous PS deficiency in mice was associated with a thrombotic phenotype, whereas total homozygous deficiency in PS was incompatible with life. ..
  8. Tchaikovski S, van Vlijmen B, Cleuren A, Thomassen M, Tchaikovski V, Tans G, et al. Pregnancy-associated changes in the hemostatic system in wild-type and factor V Leiden mice. J Thromb Haemost. 2009;7:312-8 pubmed publisher
  9. Jones L, McCarthy K, Beard J, Keen C, Jones B. Quantitative genetic analysis of brain copper and zinc in BXD recombinant inbred mice. Nutr Neurosci. 2006;9:81-92 pubmed
    ..More importantly, revelation of the genetic underpinnings of copper and zinc brain homeostasis will aid our understanding of neurological diseases that are related to copper and zinc imbalance. ..