Gene Symbol: Prok1
Description: prokineticin 1
Alias: EG-VEGF, prokineticin-1, endocrine-gland-derived vascular endothelial growth factor
Ngan E, Lee K, Sit F, Poon H, Chan J, Sham M, et al
. Prokineticin-1 modulates proliferation and differentiation of enteric neural crest cells. Biochim Biophys Acta. 2007;1773:536-45 pubmed
..Taken together, it is the first report demonstrating that Prok-1 acts as a gut mucosa/mesenchyme-derived factor and maintains proliferation and differentiation of enteric NCCs. ..
Hoffmann P, Feige J, Alfaidy N. Placental expression of EG-VEGF and its receptors PKR1 (prokineticin receptor-1) and PKR2 throughout mouse gestation. Placenta. 2007;28:1049-58 pubmed
..the expression of EG-VEGF (endocrine gland-derived vascular endothelial growth factor), also known as prokineticin 1 (PK1) in human placenta during the first trimester of pregnancy and showed that this factor is likely to play ..
Ngan E, Shum C, Poon H, Sham M, Garcia Barcelo M, Lui V, et al
. Prokineticin-1 (Prok-1) works coordinately with glial cell line-derived neurotrophic factor (GDNF) to mediate proliferation and differentiation of enteric neural crest cells. Biochim Biophys Acta. 2008;1783:467-78 pubmed
..Taken together, these findings provide evidence that Prok-1 crosstalks with GDNF/Ret signaling and probably provides an additional layer of signaling refinement to maintain proliferation and differentiation of enteric NCCs. ..
Alfaidy N. Prokineticin1 and pregnancy. Ann Endocrinol (Paris). 2016;77:101-4 pubmed publisher
b>Prokineticin 1 (PROK1), also called EG-VEGF, is a peptide of 86 amino acids with multiple biological functions. PROK1 acts via two G-protein coupled receptors: PROKR1 PROKR2. PROK1 is highly expressed in the placenta...
Cheng M, Bullock C, Li C, Lee A, Bermak J, Belluzzi J, et al
. Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus. Nature. 2002;417:405-10 pubmed
..The high expression of PKR2 mRNA within the SCN and the positive feedback of PK2 on its own transcription through activation of PKR2 suggest that PK2 may also function locally within the SCN to synchronize output. ..
Vogler C, Galvin N, Levy B, Grubb J, Jiang J, Zhou X, et al
. Transgene produces massive overexpression of human beta -glucuronidase in mice, lysosomal storage of enzyme, and strain-dependent tumors. Proc Natl Acad Sci U S A. 2003;100:2669-73 pubmed
LeCouter J, Lin R, Frantz G, Zhang Z, Hillan K, Ferrara N. Mouse endocrine gland-derived vascular endothelial growth factor: a distinct expression pattern from its human ortholog suggests different roles as a regulator of organ-specific angiogenesis. Endocrinology. 2003;144:2606-16 pubmed
..We propose that mouse EG-VEGF, like human EG-VEGF, plays a role in regulating the phenotype and growth properties of endothelial cells within distinct capillary beds. ..
Garnier V, Traboulsi W, Salomon A, Brouillet S, Fournier T, Winkler C, et al
. PPARÎ³ controls pregnancy outcome through activation of EG-VEGF: new insights into the mechanism of placental development. Am J Physiol Endocrinol Metab. 2015;309:E357-69 pubmed publisher
..The present data reveal EG-VEGF as a new mediator of PPARÎ³ effects during pregnancy and bring new insights into the fine mechanism of trophoblast invasion. ..
LeCouter J, Lin R, Tejada M, Frantz G, Peale F, Hillan K, et al
. The endocrine-gland-derived VEGF homologue Bv8 promotes angiogenesis in the testis: Localization of Bv8 receptors to endothelial cells. Proc Natl Acad Sci U S A. 2003;100:2685-90 pubmed
..The testis exhibits relatively high turnover of endothelial cells. Therefore, Bv8 and EG-VEGF, along with other factors such as VEGF-A, may maintain the integrity and also regulate proliferation of the blood vessels in the testis. ..