Prmt5

Summary

Gene Symbol: Prmt5
Description: protein arginine N-methyltransferase 5
Alias: Jbp1, Skb1, protein arginine N-methyltransferase 5, Jak-binding protein 1, SKB1 homolog, histone-arginine N-methyltransferase PRMT5, shk1 kinase-binding protein 1 homolog
Species: mouse
Products:     Prmt5

Top Publications

  1. Pal S, Vishwanath S, Erdjument Bromage H, Tempst P, SIF S. Human SWI/SNF-associated PRMT5 methylates histone H3 arginine 8 and negatively regulates expression of ST7 and NM23 tumor suppressor genes. Mol Cell Biol. 2004;24:9630-45 pubmed
    ..We have recently shown that PRMT5 can interact with flag-tagged BRG1- and hBRM-based hSWI/SNF chromatin remodelers and that both complexes can ..
  2. Ancelin K, Lange U, Hajkova P, Schneider R, Bannister A, Kouzarides T, et al. Blimp1 associates with Prmt5 and directs histone arginine methylation in mouse germ cells. Nat Cell Biol. 2006;8:623-30 pubmed
    ..Here, we show that Blimp1 has a novel interaction with Prmt5, an arginine-specific histone methyltransferase, which mediates symmetrical dimethylation of arginine 3 on histone ..
  3. Tee W, Pardo M, Theunissen T, Yu L, Choudhary J, Hajkova P, et al. Prmt5 is essential for early mouse development and acts in the cytoplasm to maintain ES cell pluripotency. Genes Dev. 2010;24:2772-7 pubmed publisher
    b>Prmt5, an arginine methyltransferase, has multiple roles in germ cells, and possibly in pluripotency. Here we show that loss of Prmt5 function is early embryonic-lethal due to the abrogation of pluripotent cells in blastocysts...
  4. Bezzi M, Teo S, Müller J, Mok W, Sahu S, Vardy L, et al. Regulation of constitutive and alternative splicing by PRMT5 reveals a role for Mdm4 pre-mRNA in sensing defects in the spliceosomal machinery. Genes Dev. 2013;27:1903-16 pubmed publisher
    ..We here investigate the role of protein arginine methyltransferase 5 (PRMT5), a putative splicing regulator and transcriptional cofactor, in mammalian development...
  5. Chittka A, Nitarska J, Grazini U, Richardson W. Transcription factor positive regulatory domain 4 (PRDM4) recruits protein arginine methyltransferase 5 (PRMT5) to mediate histone arginine methylation and control neural stem cell proliferation and differentiation. J Biol Chem. 2012;287:42995-3006 pubmed publisher
    ..We discovered that SC1 recruits the chromatin modifier PRMT5, an arginine methyltransferase that catalyzes symmetric dimethylation of histone H4 arginine 3 (H4R3me2s) and that ..
  6. Huang J, Vogel G, Yu Z, Almazan G, Richard S. Type II arginine methyltransferase PRMT5 regulates gene expression of inhibitors of differentiation/DNA binding Id2 and Id4 during glial cell differentiation. J Biol Chem. 2011;286:44424-32 pubmed publisher
    b>PRMT5 is a type II protein arginine methyltranferase that catalyzes monomethylation and symmetric dimethylation of arginine residues...
  7. Hou Z, Peng H, Ayyanathan K, Yan K, Langer E, Longmore G, et al. The LIM protein AJUBA recruits protein arginine methyltransferase 5 to mediate SNAIL-dependent transcriptional repression. Mol Cell Biol. 2008;28:3198-207 pubmed publisher
    ..Here, we describe the identification of the protein arginine methyltransferase 5 (PRMT5) as an effector recruited to SNAIL through an interaction with AJUBA that functions to repress the SNAIL target ..
  8. Vagin V, Wohlschlegel J, Qu J, Jonsson Z, Huang X, Chuma S, et al. Proteomic analysis of murine Piwi proteins reveals a role for arginine methylation in specifying interaction with Tudor family members. Genes Dev. 2009;23:1749-62 pubmed publisher
    ..Piwi proteins were found in complex with PRMT5/WDR77, an enzyme that dimethylates arginine residues...
  9. Li Z, Yu J, Hosohama L, Nee K, Gkountela S, Chaudhari S, et al. The Sm protein methyltransferase PRMT5 is not required for primordial germ cell specification in mice. EMBO J. 2015;34:748-58 pubmed publisher
    b>PRMT5 is a type II protein arginine methyltransferase with roles in stem cell biology, reprograming, cancer and neurogenesis...

More Information

Publications50

  1. van Dijk T, Gillemans N, Stein C, Fanis P, Demmers J, van de Corput M, et al. Friend of Prmt1, a novel chromatin target of protein arginine methyltransferases. Mol Cell Biol. 2010;30:260-72 pubmed publisher
    ..Our data indicate that Fop recruitment to the promoter is an early critical event in the activation of estradiol-dependent transcription. ..
  2. Du W, Amarachintha S, Erden O, Wilson A, Pang Q. The Fanconi anemia pathway controls oncogenic response in hematopoietic stem and progenitor cells by regulating PRMT5-mediated p53 arginine methylation. Oncotarget. 2016;7:60005-60020 pubmed publisher
    ..a compromised K-rasG12D-induced arginine methylation of p53 mediated by the protein arginine methyltransferase 5 (PRMT5)...
  3. Pollack B, Kotenko S, He W, Izotova L, Barnoski B, Pestka S. The human homologue of the yeast proteins Skb1 and Hsl7p interacts with Jak kinases and contains protein methyltransferase activity. J Biol Chem. 1999;274:31531-42 pubmed
    ..the clones identified represents a human homologue of the Schizosaccaromyces pombe Shk1 kinase-binding protein 1, Skb1, and the protein encoded by the Saccharomyces cerevisiae HSL7 (histone synthetic lethal 7) gene...
  4. Cho O, Mallappa C, Hernández Hernández J, Rivera Pérez J, Imbalzano A. Contrasting roles for MyoD in organizing myogenic promoter structures during embryonic skeletal muscle development. Dev Dyn. 2015;244:43-55 pubmed publisher
    ..MyoD differentially promotes activated and repressed chromatin structures at myogenic genes early after the onset of skeletal muscle differentiation in the developing mouse embryo. ..
  5. Dacwag C, Bedford M, SIF S, Imbalzano A. Distinct protein arginine methyltransferases promote ATP-dependent chromatin remodeling function at different stages of skeletal muscle differentiation. Mol Cell Biol. 2009;29:1909-21 pubmed publisher
    ..We previously demonstrated that the class II arginine methyltransferase Prmt5 was required for skeletal muscle differentiation at the early stages of myogenesis (C. S. Dacwag, Y. Ohkawa, S...
  6. Wang T, Gu S, Ronni T, Du Y, Chen X. In vivo dual-tagging proteomic approach in studying signaling pathways in immune response. J Proteome Res. 2005;4:941-9 pubmed
    ..This integrated approach provides global information on the functional link between MyD88 and other proteins in transducing the TLR-mediated signal and is generally applicable to in vivo analyses of other signaling pathways. ..
  7. Cheng D, Cote J, Shaaban S, Bedford M. The arginine methyltransferase CARM1 regulates the coupling of transcription and mRNA processing. Mol Cell. 2007;25:71-83 pubmed
  8. Aggarwal P, Vaites L, Kim J, Mellert H, Gurung B, Nakagawa H, et al. Nuclear cyclin D1/CDK4 kinase regulates CUL4 expression and triggers neoplastic growth via activation of the PRMT5 methyltransferase. Cancer Cell. 2010;18:329-40 pubmed publisher
    ..work reveals a molecular relationship between cyclin D1/CDK4 kinase and protein arginine methyltransferase 5 (PRMT5), an enzyme associated with histone methylation and transcriptional repression...
  9. Dacwag C, Ohkawa Y, Pal S, SIF S, Imbalzano A. The protein arginine methyltransferase Prmt5 is required for myogenesis because it facilitates ATP-dependent chromatin remodeling. Mol Cell Biol. 2007;27:384-94 pubmed
    ..The type II protein arginine methyltransferase Prmt5 symmetrically dimethylates histones H3 and H4 and numerous nonchromatin proteins, and prior work has implicated ..
  10. Koh C, Bezzi M, Low D, Ang W, Teo S, Gay F, et al. MYC regulates the core pre-mRNA splicing machinery as an essential step in lymphomagenesis. Nature. 2015;523:96-100 pubmed publisher
    ..upregulates the transcription of the core small nuclear ribonucleoprotein particle assembly genes, including Prmt5, an arginine methyltransferase that methylates Sm proteins...
  11. Chittka A. Differential regulation of SC1/PRDM4 and PRMT5 mediated protein arginine methylation by the nerve growth factor and the epidermal growth factor in PC12 cells. Neurosci Lett. 2013;550:87-92 pubmed publisher
    ..the PRDM family of transcriptional regulators, PRDM4/SC1, recruits a type II protein arginine methyltransferase, PRMT5, to maintain the "stem-like" cellular state of the embryonic mouse cortical NSCs...
  12. Nagamatsu G, Kosaka T, Kawasumi M, Kinoshita T, Takubo K, Akiyama H, et al. A germ cell-specific gene, Prmt5, works in somatic cell reprogramming. J Biol Chem. 2011;286:10641-8 pubmed publisher
    ..Here, we show that Blimp-1, Prdm14, and Prmt5, each of which is crucial for PGC development, have the potential to reprogram somatic cells into pluripotent stem ..
  13. Liu F, Cheng G, Hamard P, Greenblatt S, Wang L, Man N, et al. Arginine methyltransferase PRMT5 is essential for sustaining normal adult hematopoiesis. J Clin Invest. 2015;125:3532-44 pubmed publisher
    ..The major type II protein arginine methyltransferase PRMT5 catalyzes the formation of symmetric dimethyl arginine and has been implicated in various cellular processes, ..
  14. Zhang T, Günther S, Looso M, Künne C, Krüger M, Kim J, et al. Prmt5 is a regulator of muscle stem cell expansion in adult mice. Nat Commun. 2015;6:7140 pubmed publisher
    ..screen, and identify 120 genes important for MuSC function including the arginine methyltransferase Prmt5. MuSC-specific inactivation of Prmt5 in adult mice prevents expansion of MuSC, abolishes long-term MuSC ..
  15. Berrens R, Reik W. Prmt5: a guardian of the germline protects future generations. EMBO J. 2015;34:689-90 pubmed publisher
  16. Webb L, Amici S, Jablonski K, Savardekar H, Panfil A, Li L, et al. PRMT5-Selective Inhibitors Suppress Inflammatory T Cell Responses and Experimental Autoimmune Encephalomyelitis. J Immunol. 2017;198:1439-1451 pubmed publisher
    ..b>PRMT5 is the main PRMT responsible for symmetric dimethylation of arginine residues of histones and other proteins...
  17. Na J, Lee K, Kim H, Shin J, Na W, Jeong H, et al. Role of type II protein arginine methyltransferase 5 in the regulation of Circadian Per1 gene. PLoS ONE. 2012;7:e48152 pubmed publisher
    ..In this study, we identified the type II protein arginine methyltransferase 5 (PRMT5) as an interacting molecule of CRY1...
  18. Costa Y, Speed R, Gautier P, Semple C, Maratou K, Turner J, et al. Mouse MAELSTROM: the link between meiotic silencing of unsynapsed chromatin and microRNA pathway?. Hum Mol Genet. 2006;15:2324-34 pubmed
    ..The presence of MAEL in these critical compartments of male germ cells and its interactions provide a link suggesting the involvement of the miRNA pathway in MSUC...
  19. Fan Z, Kong X, Xia J, Wu X, Li H, Xu H, et al. The arginine methyltransferase PRMT5 regulates CIITA-dependent MHC II transcription. Biochim Biophys Acta. 2016;1859:687-96 pubmed publisher
    ..augmented expression, nuclear translocation, and promoter binding of the protein arginine methyltransferase PRMT5 in macrophages...
  20. Kanamaluru D, Xiao Z, Fang S, Choi S, Kim D, Veenstra T, et al. Arginine methylation by PRMT5 at a naturally occurring mutation site is critical for liver metabolic regulation by small heterodimer partner. Mol Cell Biol. 2011;31:1540-50 pubmed publisher
    ..of SHP is also increased by posttranslational methylation at Arg-57 by protein arginine methyltransferase 5 (PRMT5)...
  21. Muhammad A, Xing B, Liu C, Naji A, Ma X, Simmons R, et al. Menin and PRMT5 suppress GLP1 receptor transcript and PKA-mediated phosphorylation of FOXO1 and CREB. Am J Physiol Endocrinol Metab. 2017;313:E148-E166 pubmed publisher
    ..Here, we show that menin and protein arginine methyltransferase 5 (PRMT5) suppress GLP1 receptor (GLP1R) transcript levels...
  22. Akpinar M, Lesche M, Fanourgakis G, Fu J, Anastassiadis K, Dahl A, et al. TDRD6 mediates early steps of spliceosome maturation in primary spermatocytes. PLoS Genet. 2017;13:e1006660 pubmed publisher
    ..we show that in meiotic prophase I spermatocytes TDRD6 interacts with the key protein arginine methyl transferase PRMT5, which supports splicing...
  23. Zhang B, Zhang S, Zhu L, Chen X, Zhao Y, Chao L, et al. Arginine methyltransferase inhibitor 1 inhibits gastric cancer by downregulating eIF4E and targeting PRMT5. Toxicol Appl Pharmacol. 2017;336:1-7 pubmed publisher
    ..However, the effects of AMI-1 on type II PRMT5 activity and gastric cancer (GC) remain unclear...
  24. Chung J, Karkhanis V, Tae S, Yan F, Smith P, Ayers L, et al. Protein arginine methyltransferase 5 (PRMT5) inhibition induces lymphoma cell death through reactivation of the retinoblastoma tumor suppressor pathway and polycomb repressor complex 2 (PRC2) silencing. J Biol Chem. 2013;288:35534-47 pubmed publisher
    ..an essential role in tumorigenesis, and enhanced expression of the type II protein arginine methyltransferase PRMT5 as well as the polycomb repressor complex PRC2 has been associated with increased cell proliferation and survival...
  25. Fronz K, Otto S, Kölbel K, Kuhn U, Friedrich H, Schierhorn A, et al. Promiscuous modification of the nuclear poly(A)-binding protein by multiple protein-arginine methyltransferases does not affect the aggregation behavior. J Biol Chem. 2008;283:20408-20 pubmed publisher
    ..Thus, arginine methylation might be relevant for oculopharyngeal muscular dystrophy. However, in two different types of assays we have been unable to detect any effect of arginine methylation on the aggregation of bovine PABPN1. ..
  26. Miranda T, Khusial P, Cook J, Lee J, Gunderson S, Pestka S, et al. Spliceosome Sm proteins D1, D3, and B/B' are asymmetrically dimethylated at arginine residues in the nucleus. Biochem Biophys Res Commun. 2004;323:382-7 pubmed
    ..In reactions in which Sm D1 or Sm D3 was methylated in vitro with a hemagglutinin-tagged PRMT5 purified from HeLa cells, we detected both symmetric omega-NG,NG'-dimethylarginine and asymmetric omega-NG,NG-..
  27. Wang Y, Li Q, Liu C, Han F, Chen M, Zhang L, et al. Protein arginine methyltransferase 5 (Prmt5) is required for germ cell survival during mouse embryonic development. Biol Reprod. 2015;92:104 pubmed publisher
    ..In this study, we found that protein arginine methyltransferase 5 (Prmt5) was abundantly expressed in the germ cells of both male and female gonads...
  28. Pei Y, Niu L, Lu F, Liu C, Zhai J, Kong X, et al. Mutations in the Type II protein arginine methyltransferase AtPRMT5 result in pleiotropic developmental defects in Arabidopsis. Plant Physiol. 2007;144:1913-23 pubmed
    Human PROTEIN ARGININE METHYLTRANSFERASE5 (PRMT5) encodes a type II protein arginine (Arg) methyltransferase and its homologs in animals and yeast (Saccharomyces cerevisiae and Schizosaccharomyces pombe) are known to regulate RNA ..
  29. Leblanc S, Konda S, Wu Q, Hu Y, Oslowski C, SIF S, et al. Protein arginine methyltransferase 5 (Prmt5) promotes gene expression of peroxisome proliferator-activated receptor ?2 (PPAR?2) and its target genes during adipogenesis. Mol Endocrinol. 2012;26:583-97 pubmed publisher
    ..Here we report that inhibition of protein arginine methyltransferase 5 (Prmt5) expression in multiple cell culture models for adipogenesis prevented the activation of adipogenic genes...
  30. Clarke T, Sanchez Bailon M, Chiang K, Reynolds J, Herrero Ruiz J, Bandeiras T, et al. PRMT5-Dependent Methylation of the TIP60 Coactivator RUVBL1 Is a Key Regulator of Homologous Recombination. Mol Cell. 2017;65:900-916.e7 pubmed publisher
    ..Here we identify the arginine methyltransferase PRMT5 as a key regulator of homologous recombination (HR)-mediated double-strand break (DSB) repair, which is mediated ..
  31. Kim S, Günesdogan U, Zylicz J, Hackett J, Cougot D, Bao S, et al. PRMT5 protects genomic integrity during global DNA demethylation in primordial germ cells and preimplantation embryos. Mol Cell. 2014;56:564-79 pubmed publisher
    ..We found that PRMT5, an arginine methyltransferase, translocates from the cytoplasm to the nucleus during this process...
  32. Paul C, Sardet C, Fabbrizio E. The histone- and PRMT5-associated protein COPR5 is required for myogenic differentiation. Cell Death Differ. 2012;19:900-8 pubmed publisher
    ..Recently, it has been reported that the Protein aRginine Methyl Transferase PRMT5 modulates the early phase of induction of MYOG expression...
  33. Leblanc S, Wu Q, Lamba P, Sif S, Imbalzano A. Promoter-enhancer looping at the PPARγ2 locus during adipogenic differentiation requires the Prmt5 methyltransferase. Nucleic Acids Res. 2016;44:5133-47 pubmed publisher
    ..The arginine methyltransferase Prmt5 was required for loop formation, and overexpression of Prmt5 resulted in premature loop formation and earlier ..
  34. Cho E, Zheng S, Munro S, Liu G, Carr S, Moehlenbrink J, et al. Arginine methylation controls growth regulation by E2F-1. EMBO J. 2012;31:1785-97 pubmed publisher
    ..We show here that E2F-1 is directly methylated by PRMT5 (protein arginine methyltransferase 5), and that arginine methylation is responsible for regulating its ..
  35. Girardot M, Hirasawa R, Kacem S, Fritsch L, Pontis J, Kota S, et al. PRMT5-mediated histone H4 arginine-3 symmetrical dimethylation marks chromatin at G + C-rich regions of the mouse genome. Nucleic Acids Res. 2014;42:235-48 pubmed publisher
    ..Here, we show that the type-II protein arginine methyltransferase PRMT5 controls H4R3me2s in mouse embryonic fibroblasts (MEFs)...
  36. Yildirim A, Bulau P, Zakrzewicz D, Kitowska K, Weissmann N, Grimminger F, et al. Increased protein arginine methylation in chronic hypoxia: role of protein arginine methyltransferases. Am J Respir Cell Mol Biol. 2006;35:436-43 pubmed
    ..These data suggest that structural and functional changes caused by hypoxia may be linked to ADMA metabolism. ..
  37. Li Y, Chitnis N, Nakagawa H, Kita Y, Natsugoe S, Yang Y, et al. PRMT5 is required for lymphomagenesis triggered by multiple oncogenic drivers. Cancer Discov. 2015;5:288-303 pubmed publisher
    Protein arginine methyltransferase 5 (PRMT5) has been implicated as a key modulator of lymphomagenesis...
  38. Pettitt S, Liang Q, Rairdan X, Moran J, Prosser H, Beier D, et al. Agouti C57BL/6N embryonic stem cells for mouse genetic resources. Nat Methods. 2009;6:493-5 pubmed publisher
    ..These cells provide a robust foundation for large-scale mouse knockout programs that aim to provide a public resource of targeted mutations in the C57BL/6 genetic background. ..
  39. Gao G, Dhar S, Bedford M. PRMT5 regulates IRES-dependent translation via methylation of hnRNP A1. Nucleic Acids Res. 2017;45:4359-4369 pubmed publisher
    The type II arginine methyltransferase PRMT5 is responsible for the symmetric dimethylation of histone to generate the H3R8me2s and H4R3me2s marks, which correlate with the repression of transcription...
  40. Wang Y, Zhu T, Li Q, Liu C, Han F, Chen M, et al. Prmt5 is required for germ cell survival during spermatogenesis in mice. Sci Rep. 2015;5:11031 pubmed publisher
    ..Abnormal epigenetic modifications usually result in germ cell loss and reproductive defect. Prmt5 (Protein arginine methyltransferase 5) encodes a protein arginine methyltransferase which has been demonstrated to ..
  41. Dong Y, Song C, Wang Y, Lei Z, Xu F, Guan H, et al. Inhibition of PRMT5 suppresses osteoclast differentiation and partially protects against ovariectomy-induced bone loss through downregulation of CXCL10 and RSAD2. Cell Signal. 2017;34:55-65 pubmed publisher
    Protein arginine methyltransferase 5 (PRMT5) is an arginine methylation methyltransferase that regulates various physiological processes. Abnormal PRMT5 activity has been reported in inflammation and various types of cancers...