Prlr

Summary

Gene Symbol: Prlr
Description: prolactin receptor
Alias: AI987712, Pr-1, Pr-3, Prlr-rs1, prolactin receptor, PRL-R, prolactin receptor related sequence 1
Species: mouse
Products:     Prlr

Top Publications

  1. Kirschner M, Arriza J, Copeland N, Gilbert D, Jenkins N, Magenis E, et al. The mouse and human excitatory amino acid transporter gene (EAAT1) maps to mouse chromosome 15 and a region of syntenic homology on human chromosome 5. Genomics. 1994;22:631-3 pubmed
    ..The Eaat1 locus appears not to be linked to the epilepsy mutant stg locus, which is also on chromosome 15. The EAAT1 locus is located in a region of 5p deletions that have been associated with mental retardation and microcephaly. ..
  2. Lindeman G, Wittlin S, Lada H, Naylor M, Santamaria M, Zhang J, et al. SOCS1 deficiency results in accelerated mammary gland development and rescues lactation in prolactin receptor-deficient mice. Genes Dev. 2001;15:1631-6 pubmed
    ..Significantly, the lactogenic defect in prolactin receptor heterozygous females could be rescued by deletion of a single SOCS1 allele...
  3. Baran N, Kelly P, Binart N. Characterization of a prolactin-regulated gene in reproductive tissues using the prolactin receptor knockout mouse model. Biol Reprod. 2002;66:1210-8 pubmed
    ..Null mutation of the prolactin receptor (PRLR) gene leads to female sterility due to a failure of embryo implantation...
  4. Brisken C, Socolovsky M, Lodish H, Weinberg R. The signaling domain of the erythropoietin receptor rescues prolactin receptor-mutant mammary epithelium. Proc Natl Acad Sci U S A. 2002;99:14241-5 pubmed
    ..and erythropoietin mediate tissue-specific developmental outcomes by activating their cognate receptors, prolactin receptor (PrlR) and erythropoietin receptor (EpoR), respectively...
  5. Binart N, Imbert Bollore P, Baran N, Viglietta C, Kelly P. A short form of the prolactin (PRL) receptor is able to rescue mammopoiesis in heterozygous PRL receptor mice. Mol Endocrinol. 2003;17:1066-74 pubmed
    The heterozygous prolactin (PRL) receptor (PRLR +/-) mouse fails to develop a fully functional mammary gland at the end of the first pregnancy and shows markedly impaired lobuloalveolar development and milk secretion in young females...
  6. Binart N, Helloco C, Ormandy C, Barra J, Clement Lacroix P, Baran N, et al. Rescue of preimplantatory egg development and embryo implantation in prolactin receptor-deficient mice after progesterone administration. Endocrinology. 2000;141:2691-7 pubmed
    ..Our model establishes the PRL receptor as a key regulator of reproduction and provides novel insights into the function of lactogenic hormones and their receptor. ..
  7. Freemark M, Fleenor D, Driscoll P, Binart N, Kelly P. Body weight and fat deposition in prolactin receptor-deficient mice. Endocrinology. 2001;142:532-7 pubmed
    ..abdominal fat content, and plasma leptin concentrations in a unique model of lactogen resistance: the PRL receptor (PRLR)-deficient mouse...
  8. Riedlinger G, Okagaki R, Wagner K, Rucker E, Oka T, Miyoshi K, et al. Bcl-x is not required for maintenance of follicles and corpus luteum in the postnatal mouse ovary. Biol Reprod. 2002;66:438-44 pubmed
    ..To determine whether the prolactin receptor (PrlR), Stat5, and Bcl-x were required for establishment and maintenance of the corpus luteum, we induced ..
  9. Freemark M, Avril I, Fleenor D, Driscoll P, Petro A, Opara E, et al. Targeted deletion of the PRL receptor: effects on islet development, insulin production, and glucose tolerance. Endocrinology. 2002;143:1378-85 pubmed
    ..and the insulin secretory response to glucose in an experimental model of lactogen resistance: the PRL receptor (PRLR)-deficient mouse. We then measured plasma glucose concentrations after ip injections of glucose or insulin...

More Information

Publications87

  1. Ormandy C, Camus A, Barra J, Damotte D, Lucas B, Buteau H, et al. Null mutation of the prolactin receptor gene produces multiple reproductive defects in the mouse. Genes Dev. 1997;11:167-78 pubmed
    Mice carrying a germ-line null mutation of the prolactin receptor gene have been produced by gene targeting in embryonic stem cells...
  2. Huang C, Snider F, Cross J. Prolactin receptor is required for normal glucose homeostasis and modulation of beta-cell mass during pregnancy. Endocrinology. 2009;150:1618-26 pubmed publisher
    ..The objective of this study was to determine whether prolactin receptor (Prlr) is required for normal maternal glucose homeostasis during pregnancy...
  3. Davis J, Linzer D. Expression of multiple forms of the prolactin receptor in mouse liver. Mol Endocrinol. 1989;3:674-80 pubmed
    ..These results suggest that the varied actions of PRL may involve multiple receptors that are part of distinct signal transduction pathways. ..
  4. Viengchareun S, Servel N, Feve B, Freemark M, Lombes M, Binart N. Prolactin receptor signaling is essential for perinatal brown adipocyte function: a role for insulin-like growth factor-2. PLoS ONE. 2008;3:e1535 pubmed publisher
    ..Given the prominent role of brown adipose tissue during the perinatal period, our results identified prolactin receptor signaling as a major player and a potential therapeutic target in protecting newborn mammals against ..
  5. Devi Y, Shehu A, Stocco C, Halperin J, Le J, Seibold A, et al. Regulation of transcription factors and repression of Sp1 by prolactin signaling through the short isoform of its cognate receptor. Endocrinology. 2009;150:3327-35 pubmed publisher
    ..Our in vivo and in culture data demonstrate that the PRL-RS activates a signaling pathway distinct from that of the PRL-RL. ..
  6. Ferraris J, Boutillon F, Bernadet M, Seilicovich A, Goffin V, Pisera D. Prolactin receptor antagonism in mouse anterior pituitary: effects on cell turnover and prolactin receptor expression. Am J Physiol Endocrinol Metab. 2012;302:E356-64 pubmed publisher
    ..prolactin on proliferation and apoptosis of anterior pituitary cells and its effect on the expression of the prolactin receptor. To determine the activity of endogenous prolactin, we evaluated the effect of the competitive prolactin ..
  7. Schuff K, Hentges S, Kelly M, Binart N, Kelly P, Iuvone P, et al. Lack of prolactin receptor signaling in mice results in lactotroph proliferation and prolactinomas by dopamine-dependent and -independent mechanisms. J Clin Invest. 2002;110:973-81 pubmed
    ..We used Drd2(-/-) and Prlr(-/-) mutant mice to bypass this feedback and investigate possible dopamine-independent effects of PRL on lactotroph ..
  8. Kedzia C, Lacroix L, Ameur N, Ragot T, Kelly P, Caillou B, et al. Medullary thyroid carcinoma arises in the absence of prolactin signaling. Cancer Res. 2005;65:8497-503 pubmed
    ..To analyze prolactin effects on the thyroid gland, we first identified prolactin receptor (PRLR) mRNAs by in situ hybridization...
  9. Flint D, Binart N, Boumard S, Kopchick J, Kelly P. Developmental aspects of adipose tissue in GH receptor and prolactin receptor gene disrupted mice: site-specific effects upon proliferation, differentiation and hormone sensitivity. J Endocrinol. 2006;191:101-11 pubmed
    ..Our results provide in vivo evidence that both GH and PRL stimulate differentiation of adipocytes but that the effects of GH are site specific and induce intrinsic changes in the precursor population, which are retained in vitro. ..
  10. Halperin J, Devi Y, Devi S, Elizur S, Stocco C, Shehu A, et al. Prolactin signaling through the short form of its receptor represses forkhead transcription factor FOXO3 and its target gene galt causing a severe ovarian defect. Mol Endocrinol. 2008;22:513-22 pubmed
    ..We also provide evidence of a link between the premature ovarian failure seen in mice expressing RS and in mice with FOXO3 gene deletion as well as in human with Galt mutation. ..
  11. Goffin V, Hoang D, Bogorad R, Nevalainen M. Prolactin regulation of the prostate gland: a female player in a male game. Nat Rev Urol. 2011;8:597-607 pubmed publisher
    ..However, circulating prolactin is also detected in males and its receptor (PRLR) is expressed in the prostate, suggesting that the prostate is a target of prolactin...
  12. Gallego M, Binart N, Robinson G, Okagaki R, Coschigano K, Perry J, et al. Prolactin, growth hormone, and epidermal growth factor activate Stat5 in different compartments of mammary tissue and exert different and overlapping developmental effects. Dev Biol. 2001;229:163-75 pubmed
    ..Although Prl receptor (PrlR)-null mice are infertile, we were able to maintain pregnancies in a few mice by treatment with progesterone...
  13. Saiardi A, Bozzi Y, Baik J, Borrelli E. Antiproliferative role of dopamine: loss of D2 receptors causes hormonal dysfunction and pituitary hyperplasia. Neuron. 1997;19:115-26 pubmed
    ..These results point to prolactin as an autocrine proliferative factor in the pituitary gland. Additionally, they demonstrate an antiproliferative function for DA regulated through D2 receptor activation. ..
  14. Clarke D, Linzer D. Changes in prolactin receptor expression during pregnancy in the mouse ovary. Endocrinology. 1993;133:224-32 pubmed
    ..Some differences are also observed in the expression patterns of the individual receptor forms. Most notably, one of the short form PRL-R mRNAs is uniquely detected in atretic follicles in early to midgestation. ..
  15. Fleenor D, Oden J, Kelly P, Mohan S, Alliouachene S, Pende M, et al. Roles of the lactogens and somatogens in perinatal and postnatal metabolism and growth: studies of a novel mouse model combining lactogen resistance and growth hormone deficiency. Endocrinology. 2005;146:103-12 pubmed
    ..The model was created by breeding PRL receptor (PRLR)-deficient (knockout) males with GH-deficient (little) females...
  16. Rossi A, Teixeira Gomes R, de Jesus Simões M, Dos Santos Simões R, Oliveira P, Soares J, et al. Effects of metoclopramide-induced hyperprolactinemia on the prolactin receptor of murine endometrium. Fertil Steril. 2010;93:1643-9 pubmed publisher
    To evaluate the effects of metoclopramide-induced hyperprolactinemia on the prolactin receptor of murine endometrium.
  17. Maruoka M, Kedashiro S, Ueda Y, Mizutani K, Takai Y. Nectin-4 co-stimulates the prolactin receptor by interacting with SOCS1 and inhibiting its activity on the JAK2-STAT5a signaling pathway. J Biol Chem. 2017;292:6895-6909 pubmed publisher
    ..We previously showed that the Ig-like cell-adhesion molecule nectin-4 cis-interacts with the prolactin receptor through the extracellular region and stimulates prolactin-induced prolactin receptor activation and ..
  18. Herington A, Harrison D, Graystone J. Hepatic binding of human and bovine growth hormones and ovine prolactin in the dwarf "little" mouse. Endocrinology. 1983;112:2032-8 pubmed
    ..The failure of lit/lit mice to grow normally despite normal levels of GH receptor raises questions regarding the site and mechanism of the growth defect in the little mouse. ..
  19. Patil M, Ruparel S, Henry M, Akopian A. Prolactin regulates TRPV1, TRPA1, and TRPM8 in sensory neurons in a sex-dependent manner: Contribution of prolactin receptor to inflammatory pain. Am J Physiol Endocrinol Metab. 2013;305:E1154-64 pubmed publisher
    ..Thermal hyperalgesia in PRL KO females was restored by administration of PRL into hindpaws. Overall, we demonstrate a sex-dependent regulation of peripheral inflammatory hyperalgesia by the PRL system. ..
  20. Mayr S, Welte T, Windegger M, Lechner J, May P, Heinrich P, et al. Selective coupling of STAT factors to the mouse prolactin receptor. Eur J Biochem. 1998;258:784-93 pubmed
    ..of STAT5 by prolactin was also observed in COS-7 cells cotransfected with the long form of the mouse prolactin receptor (PRL-R) and expression vectors for STAT1, STAT3, STAT5 and STAT6...
  21. Corbacho A, Valacchi G, Kubala L, Olano Martin E, Schock B, Kenny T, et al. Tissue-specific gene expression of prolactin receptor in the acute-phase response induced by lipopolysaccharides. Am J Physiol Endocrinol Metab. 2004;287:E750-7 pubmed
    ..cytokines characteristic of the APR (TNF-alpha, IL-1beta, and IFNgamma) induced the expression of the PRL receptor (PRLR) by pulmonary fibroblasts in vitro...
  22. Zhou J, Chehab R, Tkalcevic J, Naylor M, Harris J, Wilson T, et al. Elf5 is essential for early embryogenesis and mammary gland development during pregnancy and lactation. EMBO J. 2005;24:635-44 pubmed
    ..Elf5 expression was reduced in Prolactin receptor (Prlr) heterozygous mammary glands, which phenocopy Elf5(+/-) glands, suggesting that Elf5 and Prlr are in ..
  23. Nilsson L, Binart N, Bohlooly Y M, Bramnert M, Egecioglu E, Kindblom J, et al. Prolactin and growth hormone regulate adiponectin secretion and receptor expression in adipose tissue. Biochem Biophys Res Commun. 2005;331:1120-6 pubmed
    ..Decreased serum adiponectin levels have been associated with insulin resistance, and our data in human tissue and in transgenic mice suggest a role for adiponectin in PRL and GH induced insulin resistance. ..
  24. Lascols O, Cherqui G, Munier A, Picard J, Capeau J. Differences in both glycosylation and binding properties between rat and mouse liver prolactin receptors. Cell Mol Biol (Noisy-le-grand). 1994;40:359-71 pubmed
  25. Oakes S, Robertson F, Kench J, Gardiner Garden M, Wand M, Green J, et al. Loss of mammary epithelial prolactin receptor delays tumor formation by reducing cell proliferation in low-grade preinvasive lesions. Oncogene. 2007;26:543-53 pubmed
    ..carcinogenesis in transplants of mouse mammary epithelium expressing the SV40T oncogene, with or without the prolactin receptor, using host animals with a normal endocrine system...
  26. Brown R, Kokay I, Herbison A, Grattan D. Distribution of prolactin-responsive neurons in the mouse forebrain. J Comp Neurol. 2010;518:92-102 pubmed publisher
    ..mapping of the prolactin-responsive neurons in the female mouse forebrain by describing the distribution of prolactin receptor mRNA by in situ hybridization, and measuring prolactin-induced phosphorylation of signal transducer and ..
  27. Brouwers B, de Faudeur G, Osipovich A, Goyvaerts L, Lemaire K, Boesmans L, et al. Impaired islet function in commonly used transgenic mouse lines due to human growth hormone minigene expression. Cell Metab. 2014;20:979-90 pubmed publisher
    ..These findings may be important when interpreting results obtained when these and other hGH minigene-containing transgenic mice are used. ..
  28. Hilton H, Stanford P, Harris J, Oakes S, Kaplan W, Daly R, et al. KIBRA interacts with discoidin domain receptor 1 to modulate collagen-induced signalling. Biochim Biophys Acta. 2008;1783:383-93 pubmed publisher
    ..was identified as a transcript showing decreased expression associated with failed mammary gland development in Prlr knockout mammary epithelium...
  29. Devi Y, Shehu A, Halperin J, Stocco C, Le J, Seibold A, et al. Prolactin signaling through the short isoform of the mouse prolactin receptor regulates DNA binding of specific transcription factors, often with opposite effects in different reproductive issues. Reprod Biol Endocrinol. 2009;7:87 pubmed publisher
    ..This is the first report showing PRL/PRL-RS regulation of specific transcription factors. Many of these transcription factors were not previously known to be PRL targets, suggesting novel physiological roles for this hormone. ..
  30. Tzeng S, Linzer D. Prolactin receptor expression in the developing mouse embryo. Mol Reprod Dev. 1997;48:45-52 pubmed
    We have examined the developmental pattern of prolactin receptor expression in the mouse by reverse transcription-polymerase chain reaction, in situ hybridization, and radioligand binding and have found two unexpected aspects of temporal ..
  31. Piwnica D, Fernandez I, Binart N, Touraine P, Kelly P, Goffin V. A new mechanism for prolactin processing into 16K PRL by secreted cathepsin D. Mol Endocrinol. 2006;20:3263-78 pubmed
    ..Our data support the concept that secreted lysosomal enzymes could be involved in the maintenance of angiogenesis dormancy via the generation of active antiangiogenic peptides in nonpathological contexts. ..
  32. Robertson F, Harris J, Naylor M, Oakes S, Kindblom J, Dillner K, et al. Prostate development and carcinogenesis in prolactin receptor knockout mice. Endocrinology. 2003;144:3196-205 pubmed
    ..prostate development, gene expression, and simian virus 40 (SV40)T-induced prostate carcinogenesis in prolactin receptor knockout mice...
  33. Moreno Carranza B, Goya Arce M, Vega C, Adán N, Triebel J, Lopez Barrera F, et al. Prolactin promotes normal liver growth, survival, and regeneration in rodents: effects on hepatic IL-6, suppressor of cytokine signaling-3, and angiogenesis. Am J Physiol Regul Integr Comp Physiol. 2013;305:R720-6 pubmed publisher
    ..Here, we used hyperprolactinemic rats and PRL receptor-null mice (PRLR(-/-)) to study the effect of PRL on liver growth and angiogenesis before and after partial hepatectomy (PH)...
  34. Auffret J, Viengchareun S, Carré N, Denis R, Magnan C, Marie P, et al. Beige differentiation of adipose depots in mice lacking prolactin receptor protects against high-fat-diet-induced obesity. FASEB J. 2012;26:3728-37 pubmed publisher
    ..Here we show that lack of prolactin receptor (PRLR) causes resistance to high-fat-diet-induced obesity due to enhanced energy expenditure and increased ..
  35. Chen C, Stairs D, Boxer R, Belka G, Horseman N, Alvarez J, et al. Autocrine prolactin induced by the Pten-Akt pathway is required for lactation initiation and provides a direct link between the Akt and Stat5 pathways. Genes Dev. 2012;26:2154-68 pubmed publisher
    ..to the PI3K-Akt-dependent synthesis and secretion of autocrine prolactin and downstream activation of the prolactin receptor (Prlr)-Jak-Stat5 pathway...
  36. Tsuchida Y, Kaneko Y, Otsuka T, Goto K, Saito A, Yamamoto K, et al. Upregulation of prolactin receptor in proximal tubular cells was induced in cardiac dysfunction model mice. Clin Exp Nephrol. 2014;18:65-74 pubmed publisher
    ..Gene expression of all three variants of the murine prolactin receptor was enhanced by aortic banding...
  37. Patil M, Green D, Henry M, Akopian A. Sex-dependent roles of prolactin and prolactin receptor in postoperative pain and hyperalgesia in mice. Neuroscience. 2013;253:132-41 pubmed publisher
  38. Long W, Wagner K, Lloyd K, Binart N, Shillingford J, Hennighausen L, et al. Impaired differentiation and lactational failure of Erbb4-deficient mammary glands identify ERBB4 as an obligate mediator of STAT5. Development. 2003;130:5257-68 pubmed
  39. Faisal M, Kim H, Kim J. Sexual differences of imprinted genes' expression levels. Gene. 2014;533:434-8 pubmed publisher
  40. Kim J, Mizoguchi Y, Yamaguchi H, Enami J, Sakai S. Removal of milk by suckling acutely increases the prolactin receptor gene expression in the lactating mouse mammary gland. Mol Cell Endocrinol. 1997;131:31-8 pubmed
    To determine the effect of suckling on the prolactin receptor (PRL-R) gene expression, we measured the quantity of PRL-R mRNA in the lactating mouse mammary gland...
  41. Bachelot A, Beaufaron J, Servel N, Kedzia C, Monget P, Kelly P, et al. Prolactin independent rescue of mouse corpus luteum life span: identification of prolactin and luteinizing hormone target genes. Am J Physiol Endocrinol Metab. 2009;297:E676-84 pubmed publisher
    ..We attempted to treat PRLR(-/-) females with human chorionic gonadotropin (hCG) and showed a de novo expression of LHR mRNA in the corpora ..
  42. Pasek R, Gannon M. Advancements and challenges in generating accurate animal models of gestational diabetes mellitus. Am J Physiol Endocrinol Metab. 2013;305:E1327-38 pubmed publisher
    ..Continued development of animal models of GDM is essential for understanding the consequences of this disease as well as providing insights into potential treatments and preventative measures. ..
  43. Chan C, Liu X, Ensslin M, Dillehay D, Ormandy C, Sohn P, et al. PIKE-A is required for prolactin-mediated STAT5a activation in mammary gland development. EMBO J. 2010;29:956-68 pubmed publisher
    ..The defective mammary gland development in PIKE-/- mice was rescued by overexpression of a mammary-specific cyclin D1 transgene. These data establish a critical function for PIKE-A in mediating PRL functions. ..
  44. Davis J, Linzer D. Mutational analysis of mouse placental lactogen II, and molecular characterization of the mouse prolactin receptor. Prog Clin Biol Res. 1990;342:127-32 pubmed
  45. Le J, Wilson H, Shehu A, Mao J, Devi Y, Halperin J, et al. Generation of mice expressing only the long form of the prolactin receptor reveals that both isoforms of the receptor are required for normal ovarian function. Biol Reprod. 2012;86:86 pubmed publisher
    ..of corpus luteum (CL) function and pregnancy, transduces its signal through two types of receptors, a short form (PRLR-S) and a long form (PRLR-L)...
  46. Tabata H, Kobayashi M, Ikeda J, Nakao N, Saito T, Tanaka M. Characterization of multiple first exons in murine prolactin receptor gene and the effect of prolactin on their expression in the choroid plexus. J Mol Endocrinol. 2012;48:169-76 pubmed publisher
    Prolactin (Prl) receptor (Prlr) gene is expressed in various brain regions, with the highest level present in the choroid plexus, a site for receptor-mediated PRL transport from the blood to cerebrospinal fluid...
  47. Kiapekou E, Loutradis D, Patsoula E, Koussidis G, Minas V, Bletsa R, et al. Prolactin receptor mRNA expression in oocytes and preimplantation mouse embryos. Reprod Biomed Online. 2005;10:339-46 pubmed
    ..Studies with knockout animals have shown that prolactin receptor deficient mice present reproductive defects, whereas prolactin promotes the developmental potential of ..
  48. Barker C, Bear S, Keler T, Copeland N, Gilbert D, Jenkins N, et al. Activation of the prolactin receptor gene by promoter insertion in a Moloney murine leukemia virus-induced rat thymoma. J Virol. 1992;66:6763-8 pubmed
    The prolactin receptor (Prlr) and growth hormone receptor (Ghr) genes and the Moloney murine leukemia virus integration-2 (Mlvi-2) locus were mapped to mouse chromosome 15 and human chromosome 5 bands p12-p14...
  49. Das R, Vonderhaar B. Transduction of prolactin's (PRL) growth signal through both long and short forms of the PRL receptor. Mol Endocrinol. 1995;9:1750-9 pubmed
    ..Thus, while the long form of the receptor can transduce the differentiation signal, both the long and the short forms of the receptor can signal the cells to grow. ..
  50. Gourdou I, Paly J, Hue Beauvais C, Pessemesse L, Clark J, Djiane J. Expression by transgenesis of a constitutively active mutant form of the prolactin receptor induces premature abnormal development of the mouse mammary gland and lactation failure. Biol Reprod. 2004;70:718-28 pubmed
    ..In conclusion, the expression of a constitutively active PRL-R by transgenesis induces a premature and abnormal mammary development and impairs terminal differentiation and milk production at the end of pregnancy. ..
  51. Shao S, Yao Z, Lu J, Song Y, He Z, Yu C, et al. Ablation of prolactin receptor increases hepatic triglyceride accumulation. Biochem Biophys Res Commun. 2018;498:693-699 pubmed publisher
    ..Here, we found that the estrogen-responsive pituitary hormone prolactin (PRL), through specific PRL receptor (PRLR), down-regulates hepatic triglyceride (TG) accumulation...
  52. Banerjee R, Cyphert H, Walker E, Chakravarthy H, Peiris H, Gu X, et al. Gestational Diabetes Mellitus From Inactivation of Prolactin Receptor and MafB in Islet ?-Cells. Diabetes. 2016;65:2331-41 pubmed publisher
    ..Prolactin and placental lactogen signal through the prolactin receptor (PRLR) and contribute to adaptive ?-cell responses in pregnancy; however, the in vivo requirement for PRLR ..
  53. Gouilleux F, Moritz D, Humar M, Moriggl R, Berchtold S, Groner B. Prolactin and interleukin-2 receptors in T lymphocytes signal through a MGF-STAT5-like transcription factor. Endocrinology. 1995;136:5700-8 pubmed
    ..Our results emphasize the role of PRL as a regulator of the immune response and indicate that the Stat factors mammary gland factor-Stat5 and Stat1 play a role in the regulation of gene expression during T cell development. ..
  54. Adán N, Guzmán Morales J, Ledesma Colunga M, Perales Canales S, Quintanar Stephano A, Lopez Barrera F, et al. Prolactin promotes cartilage survival and attenuates inflammation in inflammatory arthritis. J Clin Invest. 2013;123:3902-13 pubmed publisher
    ..into the knee joints of rats, whereas the proapoptotic effect of cytokines was enhanced in PRL receptor-null (Prlr(-/-)) mice...
  55. Bouchard B, Ormandy C, Di Santo J, Kelly P. Immune system development and function in prolactin receptor-deficient mice. J Immunol. 1999;163:576-82 pubmed
    ..In this report, we have characterized the development and function of the immune system in PRLR-deficient mice...
  56. Oliver C, Khaled W, Frend H, Nichols J, Watson C. The Stat6-regulated KRAB domain zinc finger protein Zfp157 regulates the balance of lineages in mammary glands and compensates for loss of Gata-3. Genes Dev. 2012;26:1086-97 pubmed publisher
    ..These data suggest that the luminal alveolar compartment of the mammary gland is comprised of a number of distinct cell populations that, although interdependant, exhibit considerable cell fate plasticity. ..
  57. Ueda E, Huang K, Nguyen V, Ferreira M, André S, Walker A. Distribution of prolactin receptors suggests an intraductal role for prolactin in the mouse and human mammary gland, a finding supported by analysis of signaling in polarized monolayer cultures. Cell Tissue Res. 2011;346:175-89 pubmed publisher
    ..mammary gland development and function, little is known about the distribution of the different forms of the prolactin receptor (PRLR) under various physiological circumstances...
  58. Mak G, Weiss S. Paternal recognition of adult offspring mediated by newly generated CNS neurons. Nat Neurosci. 2010;13:753-8 pubmed publisher
    ..Rescuing this neurogenesis restored recognition behavior. Thus, neurogenesis in the paternal brain may be involved in offspring recognition. ..
  59. Stocco C, Djiane J, Gibori G. Prostaglandin F(2alpha) (PGF(2alpha)) and prolactin signaling: PGF(2alpha)-mediated inhibition of prolactin receptor expression in the Corpus luteum. Endocrinology. 2003;144:3301-5 pubmed
    ..The results further suggest that PGF(2alpha)-mediated stimulation of 20alphaHSD is independent from PGF(2alpha) inhibition of PRL signaling in luteal cell. ..
  60. Grosdemouge I, Bachelot A, Lucas A, Baran N, Kelly P, Binart N. Effects of deletion of the prolactin receptor on ovarian gene expression. Reprod Biol Endocrinol. 2003;1:12 pubmed
    ..development, implantation and decidualization in the mouse appear to be dependent on ovarian rather than uterine PRLR expression, since progesterone replacement permits the rescue of normal implantation and early pregnancy...
  61. Shillingford J, Miyoshi K, Flagella M, Shull G, Hennighausen L. Mouse mammary epithelial cells express the Na-K-Cl cotransporter, NKCC1: characterization, localization, and involvement in ductal development and morphogenesis. Mol Endocrinol. 2002;16:1309-21 pubmed
  62. Belugin S, Diogenes A, Patil M, Ginsburg E, Henry M, Akopian A. Mechanisms of transient signaling via short and long prolactin receptor isoforms in female and male sensory neurons. J Biol Chem. 2013;288:34943-55 pubmed publisher
    ..We next reconstituted PRL-induced signaling in a heterologous expression system and TG neurons from PRL receptor (PRLR)-null mutant mice by expressing rat PRLR-long isoform (PRLR-L), PRLR-short isoform (PRLR-S), or a mix of both...
  63. Brown Borg H, Zhang F, Huhtaniemi I, Bartke A. Developmental aspects of prolactin receptor gene expression in fetal and neonatal mice. Eur J Endocrinol. 1996;134:751-7 pubmed
    The prolactin receptor (PRL-R), a member of the hematopoietin cytokine receptor superfamily, is widely distributed among mammalian tissues...
  64. Hennighausen L, Robinson G, Wagner K, Liu W. Prolactin signaling in mammary gland development. J Biol Chem. 1997;272:7567-9 pubmed
  65. Lucas B, Ormandy C, Binart N, Bridges R, Kelly P. Null mutation of the prolactin receptor gene produces a defect in maternal behavior. Endocrinology. 1998;139:4102-7 pubmed
    We have studied pup-directed maternal behavior in mice carrying a germ line null mutation of the PRL receptor (PRLR) gene. Homozygous mutant and heterozygous mutant nulliparous females show a deficiency in pup-induced maternal behavior...
  66. Costanza M, Musio S, Abou Hamdan M, Binart N, Pedotti R. Prolactin is not required for the development of severe chronic experimental autoimmune encephalomyelitis. J Immunol. 2013;191:2082-8 pubmed publisher
    ..Using PRL receptor-deficient (Prlr(-/-)) and PRL-deficient (Prl(-/-)) mice, we show that PRL plays a redundant role in the development of chronic EAE...
  67. Mori M, Kitazume M, Ose R, Kurokawa J, Koga K, Osuga Y, et al. Death effector domain-containing protein (DEDD) is required for uterine decidualization during early pregnancy in mice. J Clin Invest. 2011;121:318-27 pubmed publisher
    ..These results indicate that DEDD is indispensable for the establishment of an adequate uterine environment to support early pregnancy in mice. ..
  68. Huang C. Wild-type offspring of heterozygous prolactin receptor-null female mice have maladaptive ?-cell responses during pregnancy. J Physiol. 2013;591:1325-38 pubmed publisher
    ..This increase is accompanied by an increase in ?-cell proliferation, a process that requires intact prolactin receptor (Prlr) signalling...
  69. Reese J, Binart N, Brown N, Ma W, Paria B, Das S, et al. Implantation and decidualization defects in prolactin receptor (PRLR)-deficient mice are mediated by ovarian but not uterine PRLR. Endocrinology. 2000;141:1872-81 pubmed
    PRL and its homologs accomplish their biological effects through the PRL receptor (PRLR)...
  70. Miyoshi K, Shillingford J, Smith G, Grimm S, Wagner K, Oka T, et al. Signal transducer and activator of transcription (Stat) 5 controls the proliferation and differentiation of mammary alveolar epithelium. J Cell Biol. 2001;155:531-42 pubmed
    ..We examined the specific contributions of the prolactin receptor (PrlR) and the signal transducers and activators of transcription 5a and 5b (referred to as Stat5) in the ..
  71. Goffin V, Binart N, Clement Lacroix P, Bouchard B, Bole Feysot C, Edery M, et al. From the molecular biology of prolactin and its receptor to the lessons learned from knockout mice models. Genet Anal. 1999;15:189-201 pubmed
    ..The initial step of PRL action is the binding to a specific membrane receptor, the PRLR, which belongs to the class 1 cytokine receptor superfamily...
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    ..Moreover, retinas from prolactin receptor-deficient mice exhibited photoresponsive dysfunction and gliosis that correlated with decreased levels of ..
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    ..In addition, it provides a basis for targeted studies designed to identify causes of idiopathic XY DSD. ..
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    PRL has been reported to regulate fat metabolism in several species. We recently reported PRL receptor (PRLR) expression in mouse adipocytes and increased levels of PRLR expression in the adipose tissue of lactating and PRL-transgenic ..
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    ..Since anterior pituitary cells express the prolactin receptor (PRLR), we aimed to address the actual role of PRL in the regulation of pituitary cell turnover in cycling ..
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    The heterozygous prolactin (PRL) receptor (PRLR(+/-)) mouse fails to develop a fully functional mammary gland at the end of the first pregnancy and shows markedly impaired lobuloalveolar development and milk secretion in young females...