Prkd1

Summary

Gene Symbol: Prkd1
Description: protein kinase D1
Alias: PKD, PKD1, Pkcm, Prkcm, serine/threonine-protein kinase D1, nPKC-D1, nPKC-mu, protein kinase C mu type, protein kinase C, mu, protein kinase D
Species: mouse

Top Publications

  1. ncbi Expression and characterization of PKD, a phorbol ester and diacylglycerol-stimulated serine protein kinase
    J V Van Lint
    Growth Regulation Laboratory, Imperial Cancer Research Fund, London, United Kingdom
    J Biol Chem 270:1455-61. 1995
  2. pmc Protein kinase D is implicated in the reversible commitment to differentiation in primary cultures of mouse keratinocytes
    Azadeh Jadali
    Graduate Program in Molecular and Cellular Biology, Stony Brook University, Stony Brook, New York 11794, USA
    J Biol Chem 285:23387-97. 2010
  3. pmc Distinct sarcomeric substrates are responsible for protein kinase D-mediated regulation of cardiac myofilament Ca2+ sensitivity and cross-bridge cycling
    Sonya C Bardswell
    Cardiovascular Division, King s College London, London SE1 7EH, United Kingdom
    J Biol Chem 285:5674-82. 2010
  4. pmc Protein kinase D1 is essential for MyD88-dependent TLR signaling pathway
    Jeoung Eun Park
    Department of Pediatrics, Children s Foundation Research Center, Le Bonheur Children s Medical Center, University of Tennessee Health Science Center, Memphis, TN 38103, USA
    J Immunol 182:6316-27. 2009
  5. pmc Regulation of PKD by the MAPK p38delta in insulin secretion and glucose homeostasis
    Grzegorz Sumara
    Institute of Cell Biology, ETH Zurich, CH 8093 Zurich, Switzerland
    Cell 136:235-48. 2009
  6. pmc Protein kinase D1: a new component in TLR9 signaling
    Jeoung Eun Park
    Children s Foundation Research Center at Le Bonheur Children s Medical Center and Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN 38103, USA
    J Immunol 181:2044-55. 2008
  7. pmc Requirement of protein kinase D1 for pathological cardiac remodeling
    Jens Fielitz
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9148, USA
    Proc Natl Acad Sci U S A 105:3059-63. 2008
  8. ncbi Protein kinase D selectively targets cardiac troponin I and regulates myofilament Ca2+ sensitivity in ventricular myocytes
    Friederike Cuello
    Cardiovascular Division, King s College London, London, UK
    Circ Res 100:864-73. 2007
  9. ncbi Diacylglycerol and protein kinase D localization during T lymphocyte activation
    Martin Spitaler
    University of Dundee WTB, Dow Street, Dundee DD2 1BE, United Kingdom
    Immunity 24:535-46. 2006
  10. ncbi Expression of the protein kinase D (PKD) family during mouse embryogenesis
    Henrik Oster
    Laboratories for Chronobiology and Signal Transduction, Max Planck Institute of Experimental Endocrinology, Feodor Lynen Str 7, 30625 Hannover, Germany
    Gene Expr Patterns 6:400-8. 2006

Scientific Experts

  • Yuji Nagayama
  • John C Lee
  • Joost J F P Luiken
  • H Oster
  • M Avkiran
  • Martin Spitaler
  • Elena Vigorito
  • Ellen Dirkx
  • James Sinnett-Smith
  • Young In Kim
  • Jeoung Eun Park
  • Geou Yarh Liou
  • Friederike Cuello
  • Enrique Rozengurt
  • Victoria McEneaney
  • Ae Kyung Yi
  • Robert S Haworth
  • Erda Avriyanti
  • Peter Storz
  • Heike Döppler
  • Nur Atik
  • Robert W Schwenk
  • Steven H Young
  • Guillaume J J M van Eys
  • Jan F C Glatz
  • Klaus Pfizenmaier
  • Angelika Hausser
  • Grzegorz Sumara
  • Sonya C Bardswell
  • Jens Fielitz
  • Mi Sung Kim
  • Jim C Norman
  • Mehran Najibi
  • Ruthala Kalyani
  • Michael Leitges
  • Howard C Crawford
  • Eric N Olson
  • Muhammet Ay
  • Norbert Bencsik
  • Akihiro Harada
  • Naomi Furumoto
  • Reiko Harada
  • Shin ichiro Yoshimura
  • Masataka Kunii
  • Dominic P White
  • Mohammad Rashel
  • Vivek Choudhary
  • C Blake Nichols
  • Alexandra J Candasamy
  • Nicole Hoebers
  • Will A Coumans
  • Jeffery J Ford
  • Mika Shimamura
  • Ligia I Bastea
  • Katalin Schlett
  • Kornelia Ellwanger
  • M Ferdaoussi
  • Márton Gulyás
  • Mathias Gautel
  • Soosan Ghazizadeh
  • Arne Ittner
  • Claudine Christoforides
  • Nora Rozengurt
  • Sakthivel Sadayappan
  • Ryan H Newton
  • Noriyuki Iwamoto
  • Motoyuki Kondo
  • S N Arun
  • Romeo Ricci
  • Manuel Mayr
  • Sharon A Matthews
  • Brian J Harvey
  • Kok Choi Kong
  • Dilja D Krueger
  • Jessica A Hall
  • Azadeh Jadali
  • Ruth Dooley
  • Warren Thomas
  • Wendy B Bollag
  • Kalani L Raphael
  • Katalin Czöndör
  • Eric D Jensen
  • Jonathan C Kentish
  • Linglin Xie
  • John M Shelton
  • Dong Min Yin
  • Yun Sook Lim
  • James A Richardson
  • Rhonda Bassel-Duby
  • Tim Eiseler

Detail Information

Publications73

  1. ncbi Expression and characterization of PKD, a phorbol ester and diacylglycerol-stimulated serine protein kinase
    J V Van Lint
    Growth Regulation Laboratory, Imperial Cancer Research Fund, London, United Kingdom
    J Biol Chem 270:1455-61. 1995
    A novel protein kinase (named PKD) with an NH2-terminal region containing two cysteine-rich motifs has been expressed in COS-7 cells and identified as a receptor for phorbol esters...
  2. pmc Protein kinase D is implicated in the reversible commitment to differentiation in primary cultures of mouse keratinocytes
    Azadeh Jadali
    Graduate Program in Molecular and Cellular Biology, Stony Brook University, Stony Brook, New York 11794, USA
    J Biol Chem 285:23387-97. 2010
    ..These responses were inhibited by Goedecke 6976, an inhibitor of protein kinase D (PKD) and PKCalpha, but not with GF109203X, a general inhibitor of PKCs, suggesting PKD activation by a PKC-..
  3. pmc Distinct sarcomeric substrates are responsible for protein kinase D-mediated regulation of cardiac myofilament Ca2+ sensitivity and cross-bridge cycling
    Sonya C Bardswell
    Cardiovascular Division, King s College London, London SE1 7EH, United Kingdom
    J Biol Chem 285:5674-82. 2010
    b>Protein kinase D (PKD), a serine/threonine kinase with emerging cardiovascular functions, phosphorylates cardiac troponin I (cTnI) at Ser(22)/Ser(23), reduces myofilament Ca(2+) sensitivity, and accelerates cross-bridge cycle kinetics...
  4. pmc Protein kinase D1 is essential for MyD88-dependent TLR signaling pathway
    Jeoung Eun Park
    Department of Pediatrics, Children s Foundation Research Center, Le Bonheur Children s Medical Center, University of Tennessee Health Science Center, Memphis, TN 38103, USA
    J Immunol 182:6316-27. 2009
    Protein kinase D1 (PKD1) has been shown to be involved in certain MAPK activation and cytokine expression by several TLR ligands...
  5. pmc Regulation of PKD by the MAPK p38delta in insulin secretion and glucose homeostasis
    Grzegorz Sumara
    Institute of Cell Biology, ETH Zurich, CH 8093 Zurich, Switzerland
    Cell 136:235-48. 2009
    ..Deletion of p38delta results in pronounced activation of protein kinase D (PKD), the latter of which we have identified as a pivotal regulator of stimulated insulin exocytosis...
  6. pmc Protein kinase D1: a new component in TLR9 signaling
    Jeoung Eun Park
    Children s Foundation Research Center at Le Bonheur Children s Medical Center and Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN 38103, USA
    J Immunol 181:2044-55. 2008
    Protein kinase D1 (PKD1) is expressed ubiquitously and regulates diverse cellular processes such as oxidative stress, gene expression, cell survival, and vesicle trafficking...
  7. pmc Requirement of protein kinase D1 for pathological cardiac remodeling
    Jens Fielitz
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9148, USA
    Proc Natl Acad Sci U S A 105:3059-63. 2008
    ..b>Protein kinase D (PKD) is a stress-responsive kinase that phosphorylates class II HDACs, resulting in their dissociation from ..
  8. ncbi Protein kinase D selectively targets cardiac troponin I and regulates myofilament Ca2+ sensitivity in ventricular myocytes
    Friederike Cuello
    Cardiovascular Division, King s College London, London, UK
    Circ Res 100:864-73. 2007
    b>Protein kinase D (PKD) is a serine/threonine kinase with emerging myocardial functions; in skinned adult rat ventricular myocytes (ARVMs), recombinant PKD catalytic domain phosphorylates cardiac troponin I at Ser22/Ser23 and reduces ..
  9. ncbi Diacylglycerol and protein kinase D localization during T lymphocyte activation
    Martin Spitaler
    University of Dundee WTB, Dow Street, Dundee DD2 1BE, United Kingdom
    Immunity 24:535-46. 2006
    The serine kinase protein kinase D (PKD) has a cysteine-rich domain (CRD) that binds diacylglycerol (DAG) with high affinity...
  10. ncbi Expression of the protein kinase D (PKD) family during mouse embryogenesis
    Henrik Oster
    Laboratories for Chronobiology and Signal Transduction, Max Planck Institute of Experimental Endocrinology, Feodor Lynen Str 7, 30625 Hannover, Germany
    Gene Expr Patterns 6:400-8. 2006
    The serine/threonine protein kinase D (PKD) family comprises of three members, PKD1 (PKCmu), PKD2 and PKD3 (PKCnu). Like the related C-type protein kinases (PKCs), PKDs are activated by diacylglycerol (DAG)...
  11. ncbi Regulation of protein kinase D during differentiation and proliferation of primary mouse keratinocytes
    M Ernest Dodd
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Invest Dermatol 125:294-306. 2005
    ..b>Protein kinase D (PKD), a serine/threonine kinase, is expressed in proliferating keratinocytes, and PKD activation occurs in ..
  12. pmc PKD1/PKCmu promotes alphavbeta3 integrin recycling and delivery to nascent focal adhesions
    Alison J Woods
    Department of Biochemistry, University of Leicester, Leicester, UK
    EMBO J 23:2531-43. 2004
    ..Primaquine strongly promoted association of alphavbeta3 integrin with PKD1, and fluorescence microscopy indicated that integrin and PKD1 associate at a vesicular compartment that is ..
  13. ncbi Characterization of serine 916 as an in vivo autophosphorylation site for protein kinase D/Protein kinase Cmu
    S A Matthews
    Lymphocyte Activation Laboratory, Imperial Cancer Research Fund, Lincoln s Inn Fields, London WC2A 3PX, United Kingdom
    J Biol Chem 274:26543-9. 1999
    Activation of the serine kinase protein kinase D (PKD)/PKCmicro is controlled by the phosphorylation of two serine residues within its activation loop via a PKC-dependent signaling cascade...
  14. ncbi Protein kinase D regulates the fission of cell surface destined transport carriers from the trans-Golgi network
    M Liljedahl
    Biology Department, University of California, San Diego, La Jolla, CA 92093, USA
    Cell 104:409-20. 2001
    When a kinase inactive form of Protein Kinase D (PKD-K618N) was expressed in HeLa cells, it localized to the trans-Golgi network (TGN) and caused extensive tubulation...
  15. pmc Protein kinase D1 mediates class IIa histone deacetylase phosphorylation and nuclear extrusion in intestinal epithelial cells: role in mitogenic signaling
    James Sinnett-Smith
    Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine, CURE Digestive Diseases Research Center and Molecular Biology Institute, University of California at Los Angeles, Los Angeles, California and
    Am J Physiol Cell Physiol 306:C961-71. 2014
    ..whether class IIa histone deacetylases (HDACs) play a role in mitogenic signaling mediated by protein kinase D1 (PKD1) in IEC-18 intestinal epithelial cells...
  16. pmc An Evolutionarily Conserved PLC-PKD-TFEB Pathway for Host Defense
    Mehran Najibi
    Laboratory of Comparative Immunology, Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital Research Institute, Harvard Medical School, Boston, MA 02114, USA
    Cell Rep 15:1728-42. 2016
    ..elegans to discover a pathway that activates TFEB during infection. Gene dkf-1, which encodes a homolog of protein kinase D (PKD), was required for TFEB activation in nematodes infected with Staphylococcus aureus...
  17. doi Postnatal expression of BRAFV600E does not induce thyroid cancer in mouse models of thyroid papillary carcinoma
    Mika Shimamura
    MD, Department of Molecular Medicine, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki 852 8523 Japan
    Endocrinology 154:4423-30. 2013
    ..These results suggest that BRAF(V600E) does not appear to induce PTC-like lesions when expressed in a fraction of thyroid cells postnatally under normal TSH concentrations. ..
  18. pmc Protein kinase D1 is essential for bone acquisition during pubertal growth
    Jeffery J Ford
    PhD, Department of Biochemistry, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229
    Endocrinology 154:4182-91. 2013
    ..b>Protein kinase D (PKD) is a member of the Ca(2+)/calmodulin-dependent kinase superfamily of serine/threonine kinases and has ..
  19. pmc Protein kinase D1 has a key role in wound healing and skin carcinogenesis
    Mohammad Rashel
    Department of Oral Biology and Pathology, Stony Brook University, Stony Brook, New York, USA
    J Invest Dermatol 134:902-9. 2014
    b>Protein kinase D (PKD) is a family of stress-responsive serine/threonine kinases implicated in the regulation of diverse cellular functions including cell growth, differentiation, apoptosis, and cell motility...
  20. pmc Phosphoregulation of the titin-cap protein telethonin in cardiac myocytes
    Alexandra J Candasamy
    From the Cardiovascular Division, King s College London British Heart Foundation Centre, London SE1 7EH, United Kingdom
    J Biol Chem 289:1282-93. 2014
    ..Our previous work identified cardiac telethonin as an interaction partner for the protein kinase D catalytic domain...
  21. ncbi The role of PKD in cell polarity, biosynthetic pathways, and organelle/F-actin distribution
    Nur Atik
    Department of Cell Biology, Graduate School of Medicine, Osaka University
    Cell Struct Funct 39:61-77. 2014
    b>Protein Kinase D (PKD) 1, 2, and 3 are members of the PKD family...
  22. pmc β-adrenergic signaling inhibits Gq-dependent protein kinase D activation by preventing protein kinase D translocation
    C Blake Nichols
    From the Department of Pharmacology, University of California, Davis C B N, C W C, M F, B M W, M L S, A J F, D H, R R R, J B Department of Physiology, Loyola University Chicago, Maywood, IL C W C and School of Engineering, Department of Engineering Design and Production, Aalto University School of Science and Technology, Helsinki, Finland S B
    Circ Res 114:1398-409. 2014
    ..How these stimuli interact at the level of protein kinase D (PKD), a nodal point in cardiac hypertrophic signaling, remains unclear.
  23. pmc Genes Frequently Coexpressed with Hoxc8 Provide Insight into the Discovery of Target Genes
    Ruthala Kalyani
    Department of Anatomy, Embryology Lab, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul 03722, Korea
    Mol Cells 39:395-402. 2016
    ..We randomly selected Adam19, Ptpn13, Prkd1, Tgfbi, and Aldh1a3, and validated their coexpression in mouse embryonic tissues and cell lines following TGF-β2 ..
  24. doi Protein kinase-D1 overexpression prevents lipid-induced cardiac insulin resistance
    Ellen Dirkx
    Department of Molecular Genetics, Cardiovascular Research Institute Maastricht CARIM, Maastricht University, The Netherlands
    J Mol Cell Cardiol 76:208-17. 2014
    ..Protein kinase-D1 (PKD1) is involved in contraction-induced glucose, but not LCFA, uptake allowing to hypothesize that this kinase is an ..
  25. pmc Protein kinase D1 deficiency promotes differentiation in epidermal keratinocytes
    Vivek Choudhary
    Charlie Norwood VA Medical Center, Augusta, GA 30904, USA Department of Physiology, Medical College of Georgia at Georgia Regents University, Augusta, GA 30912, USA Section of Dermatology, Department of Medicine, Medical College of Georgia at Georgia Regents University, Augusta, GA 30912, USA
    J Dermatol Sci 76:186-95. 2014
    b>Protein kinase D (PKD or PKD1) is a serine/threonine protein kinase that has been shown to play a role in a variety of cellular processes; however, the function of PKD1 in the skin has not been fully investigated...
  26. doi Functional redundancy of protein kinase D1 and protein kinase D2 in neuronal polarity
    Erda Avriyanti
    Department of Cell Biology, Graduate School of Medicine, Osaka University, Suita, 565 0871, Japan
    Neurosci Res 95:12-20. 2015
    Mammalian protein kinase D (PKD) isoforms have been proposed to regulate diverse biological processes, including the establishment and maintenance of neuronal polarity...
  27. pmc Protein kinase D1 drives pancreatic acinar cell reprogramming and progression to intraepithelial neoplasia
    Geou Yarh Liou
    Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Mayo Clinic, Jacksonville, Florida 32224, USA
    Nat Commun 6:6200. 2015
    ..Here, using a conditional knockout approach, we show that protein kinase D1 (PKD1) is sufficient to drive the reprogramming process to a ductal phenotype and progression to PanINs...
  28. pmc Molecular cloning, epigenetic regulation, and functional characterization of Prkd1 gene promoter in dopaminergic cell culture models of Parkinson's disease
    Muhammet Ay
    Parkinson s Disorder Research Laboratory, Department of Biomedical Sciences, Iowa Center for Advanced Neurotoxicology, Iowa State University, Ames, Iowa, USA
    J Neurochem 135:402-15. 2015
    ..To investigate the molecular mechanism of Prkd1 gene expression, we cloned the 5'-flanking region (1620-bp) of the mouse Prkd1 gene...
  29. pmc Protein kinase D promotes plasticity-induced F-actin stabilization in dendritic spines and regulates memory formation
    Norbert Bencsik
    Department of Physiology and Neurobiology, Eotvos Lorand University, H 1117 Budapest, Hungary
    J Cell Biol 210:771-83. 2015
    ..In nonneuronal cells, protein kinase D (PKD) has an important role in stabilizing F-actin via multiple molecular pathways...
  30. pmc Mutant KRas-Induced Mitochondrial Oxidative Stress in Acinar Cells Upregulates EGFR Signaling to Drive Formation of Pancreatic Precancerous Lesions
    Geou Yarh Liou
    Department of Cancer Biology, Mayo Clinic, Jacksonville, FL 32224, USA
    Cell Rep 14:2325-36. 2016
    ..Hence, our data provide insight into how oncogenic KRas interacts with growth factor signaling to induce the formation of pancreatic cancer...
  31. pmc alpha v beta3 and alpha5beta1 integrin recycling pathways dictate downstream Rho kinase signaling to regulate persistent cell migration
    Dominic P White
    Integrin Cell Biology Laboratory, Beatson Institute for Cancer Research, Bearsden, Glasgow, Scotland, UK
    J Cell Biol 177:515-25. 2007
    ..We show that autophosphorylation of protein kinase D1 (PKD1) at Ser(916) is necessary for its association with alphavbeta3 integrin...
  32. pmc Inactivation of Pkd1 in principal cells causes a more severe cystic kidney disease than in intercalated cells
    Kalani L Raphael
    Division of Nephrology, University of Utah Health Sciences Center, Salt Lake City, UT 84132, USA
    Kidney Int 75:626-33. 2009
    ..To determine this, we crossed mice containing loxP sites within introns 1 and 4 of the Pkd1 gene with transgenic mice expressing Cre recombinase under control of the aquaporin-2 promoter or the B1 subunit of ..
  33. pmc Regulation of PTEN activity by p38δ-PKD1 signaling in neutrophils confers inflammatory responses in the lung
    Arne Ittner
    Institute of Cell Biology, Eidgenossische Technische Hochschule Zurich, 8006 Zurich, Switzerland
    J Exp Med 209:2229-46. 2012
    ..p38δ counteracts the activity of its downstream target protein kinase D1 (PKD1) in neutrophils and myeloid-restricted inactivation of PKD1 leads to exacerbated lung inflammation...
  34. pmc Interleukin-1 receptor-associated kinase 2- and protein kinase D1-dependent regulation of IRAK-monocyte expression by CpG DNA
    Young In Kim
    Children s Foundation Research Institute at Le Bonheur Children s Hospital and Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America
    PLoS ONE 7:e43970. 2012
    ..or gene-specific knockdown of signaling modulators in the TLR9 pathway demonstrated that IRAK4, IRAK1, IRAK2, and PKD1 are required for Irak-m transcription induced by CpG DNA...
  35. doi Protein kinase D increases maximal Ca2+-activated tension of cardiomyocyte contraction by phosphorylation of cMyBP-C-Ser315
    Ellen Dirkx
    Department of Molecular Genetics, Cardiovascular Research Institute Maastricht, Maastricht University, The Netherlands
    Am J Physiol Heart Circ Physiol 303:H323-31. 2012
    ..Recent evidence showed that protein kinase D (PKD) is one of the kinases that phosphorylate cMyBP-C...
  36. pmc Rapid protein kinase D1 signaling promotes migration of intestinal epithelial cells
    Steven H Young
    Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine, CURE, University of California at Los Angeles, Los Angeles, CA 90095 1786, USA
    Am J Physiol Gastrointest Liver Physiol 303:G356-66. 2012
    We have examined the role of protein kinase D1 (PKD1) signaling in intestinal epithelial cell migration...
  37. pmc Protein kinase D1 is essential for contraction-induced glucose uptake but is not involved in fatty acid uptake into cardiomyocytes
    Ellen Dirkx
    Department of Molecular Genetics and Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht 6200 MD, The Netherlands
    J Biol Chem 287:5871-81. 2012
    ..contraction activates the signaling enzymes AMP-activated protein kinase (AMPK) and protein kinase D1 (PKD1)...
  38. pmc Bone morphogenic protein 2 activates protein kinase D to regulate histone deacetylase 7 localization and repression of Runx2
    Eric D Jensen
    School of Dentistry, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Biol Chem 284:2225-34. 2009
    ..The protein kinase D (PKD) inhibitor Gö6976 blocked both basal and BMP2-directed HDAC7 nuclear export...
  39. pmc PKD controls αvβ3 integrin recycling and tumor cell invasive migration through its substrate Rabaptin-5
    Claudine Christoforides
    Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Dev Cell 23:560-72. 2012
    Integrin recycling is critical for cell migration. Protein kinase D (PKD) mediates signals from the platelet-derived growth factor receptor (PDGF-R) to control αvβ3 integrin recycling...
  40. pmc G protein-coupled receptor (GPR)40-dependent potentiation of insulin secretion in mouse islets is mediated by protein kinase D1
    M Ferdaoussi
    Montreal Diabetes Research Center, CRCHUM, Technopole Angus, 2901 Rachel Est, Montreal, QC, Canada H1W 4A4
    Diabetologia 55:2682-92. 2012
    ..GPR40 couples to the G protein subunit Gα(q/11) but the signalling cascade activated downstream is unknown. This study aimed to determine the mechanisms of GPR40-dependent potentiation of GSIS by fatty acids...
  41. pmc Protein kinase D1 maintains the epithelial phenotype by inducing a DNA-bound, inactive SNAI1 transcriptional repressor complex
    Ligia I Bastea
    Department of Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America
    PLoS ONE 7:e30459. 2012
    ..In cancer cells loss of E-cadherin expression contributes to an invasive phenotype. This can be mediated by SNAI1, a transcriptional repressor for E-cadherin that contributes to epithelial-to-mesenchymal transition (EMT)...
  42. doi Both the establishment and maintenance of neuronal polarity require the activity of protein kinase D in the Golgi apparatus
    Dong Min Yin
    Neuroscience Research Institute and Department of Neurobiology, Key Laboratory for Neuroscience of Ministry of Education and Health, Peking University, Beijing 100083, People s Republic of China
    J Neurosci 28:8832-43. 2008
    ..b>Protein kinase D (PKD) constitutes a family of serine/threonine-specific protein kinases and is important in regulating Golgi ..
  43. ncbi Protein kinase D1 phosphorylates HDAC7 and induces its nuclear export after T-cell receptor activation
    Maribel Parra
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, California 94158, USA
    J Biol Chem 280:13762-70. 2005
    ..Protein kinase D1 (PKD1) was activated after TCR engagement, interacted with HDAC7, and phosphorylated three serines (Ser155, Ser318, and ..
  44. ncbi Protein kinase D1 and the beta 1 integrin cytoplasmic domain control beta 1 integrin function via regulation of Rap1 activation
    Ricardo B Medeiros
    Department of Laboratory Medicine and Pathology, Center for Immunology, Cancer Center, University of Minnesota Medical School, Minneapolis, 55455, USA
    Immunity 23:213-26. 2005
    ..We report a novel function for the PKC effector protein kinase D1 (PKD1) in integrin activation...
  45. ncbi G protein-coupled receptor-mediated phosphorylation of the activation loop of protein kinase D: dependence on plasma membrane translocation and protein kinase Cepsilon
    Osvaldo Rey
    Department of Medicine, UCLA CURE Digestive Diseases Research Center and Molecular Biology Institute, David Geffen School of Medicine, University of California Los Angeles, CA 90095, USA
    J Biol Chem 279:34361-72. 2004
    b>Protein kinase D (PKD) is a serine/threonine protein kinase activated by G protein-coupled receptor (GPCR) agonists through an incompletely characterized mechanism that includes its reversible plasma membrane translocation and activation ..
  46. ncbi Synergistic activation of PKD by the B cell antigen receptor and CD19 requires PI3K, Vav1 and PLCgamma
    Elena Vigorito
    Laboratory of Lymphocyte Signaling and Development, The Babraham Institute, Babraham Research Campus, Cambridge CB2 4AT, UK
    Cell Signal 18:1455-60. 2006
    ..We now show that protein kinase D (also known as PKCmu) is also a point of convergence of these signalling pathways...
  47. ncbi Up-regulation and increased phosphorylation of protein kinase C (PKC) delta, mu and theta in the degenerating rd1 mouse retina
    Seifollah Azadi
    Department of Ophthalmology, Lund University, BMC B13, SE 221 84 Lund, Sweden
    Mol Cell Neurosci 31:759-73. 2006
    ..Our results suggest that these PKC isoforms are involved in rd1 degeneration...
  48. ncbi Specific isoforms of protein kinase C are essential for prevention of folate-resistant neural tube defects by inositol
    Patricia Cogram
    Neural Development Unit, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Hum Mol Genet 13:7-14. 2004
    ..Hindgut cell proliferation was stimulated specifically by inositol, an effect that required activation of PKCbetaI. Our findings reveal an essential role of specific PKC isoforms in mediating the prevention of mouse NTDs by inositol...
  49. ncbi Protein kinase C-independent activation of protein kinase D is involved in BMP-2-induced activation of stress mitogen-activated protein kinases JNK and p38 and osteoblastic cell differentiation
    Jérome Lemonnier
    Division of Bone Diseases, Department of Geriatrics, University Hospital of Geneva, CH 1211 Geneva 14, Switzerland
    J Biol Chem 279:259-64. 2004
    ..Activation of JNK and p38 induced by BMP-2 was blocked by the protein kinase C/protein kinase D (PKC/PKD) inhibitor Go6976 but not by the related compound, Go6983, a selective inhibitor of conventional ..
  50. pmc Protein kinase Cmu plays an essential role in hypertonicity-induced heat shock protein 70 expression
    Yun Sook Lim
    ILCHUN Genomic Medicine Institute and Seoul National University College of Medicine, Seoul 110 799, Korea
    Exp Mol Med 40:596-606. 2008
    ..From our results, we have concluded that PKCmu performs a critical function in hypertonicity-induced HSP70 induction, and finally cellular protection, via the indirect regulation of TonEBP modification...
  51. ncbi PKD is recruited to sites of actin remodelling at the leading edge and negatively regulates cell migration
    Tim Eiseler
    Institute of Cell Biology and Immunology, University of Stuttgart, Allmandring 31, 70569 Stuttgart, Germany
    FEBS Lett 581:4279-87. 2007
    b>Protein kinase D (PKD) has been implicated in the regulation of cell shape, adhesion, and migration. At the leading edge of migrating cells active PKD co-localizes with F-actin, Arp3 and cortactin...
  52. ncbi Regulation of protein kinase D activity in adult myocardium: novel counter-regulatory roles for protein kinase Cepsilon and protein kinase A
    Robert S Haworth
    Cardiovascular Division, King s College London, The Rayne Institute, St Thomas Hospital, Lambeth Palace Road, London, UK
    J Mol Cell Cardiol 43:686-95. 2007
    b>Protein kinase D (PKD) is activated downstream of protein kinase C (PKC) in many cell types, although little is known about the mechanisms that regulate PKD in adult myocardium...
  53. doi Identification of protein kinase D as a novel contraction-activated kinase linked to GLUT4-mediated glucose uptake, independent of AMPK
    Joost J F P Luiken
    Department of Molecular Genetics, Cardiovascular Research Institute Maastricht CARIM, Maastricht University, Maastricht, The Netherlands
    Cell Signal 20:543-56. 2008
    ..We examined whether the diacylglycerol-sensitive protein kinase D (PKD; also known as novel PKC isoform mu) is also involved in the regulation of glucose uptake in the ..
  54. pmc Adiponectin and leptin are secreted through distinct trafficking pathways in adipocytes
    Linglin Xie
    Division of Biology, Kansas State University, Manhattan, KS 66506, USA
    Biochim Biophys Acta 1782:99-108. 2008
    ..Taken together, these results suggest that leptin and adiponectin secretion involve distinct intracellular compartments and that endosomal compartments are required for adiponectin but not for leptin secretion...
  55. doi Protein kinase d in the cardiovascular system: emerging roles in health and disease
    Metin Avkiran
    Cardiovascular Division, King s College London, The Rayne Institute, St Thomas Hospital, London SE1 7EH, United Kingdom
    Circ Res 102:157-63. 2008
    The protein kinase D (PKD) family is a recent addition to the calcium/calmodulin-dependent protein kinase group of serine/threonine kinases, within the protein kinase complement of the mammalian genome...
  56. pmc Protein kinase D1 stimulates MEF2 activity in skeletal muscle and enhances muscle performance
    Mi Sung Kim
    Department of Molecular Biology, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
    Mol Cell Biol 28:3600-9. 2008
    ..Here we demonstrate that protein kinase D1 (PKD1), a highly effective class II HDAC kinase, is predominantly expressed in type I myofibers and, when misexpressed in ..
  57. ncbi The expression and stage-specific localization of protein kinase C isotypes during mouse preimplantation development
    C M Pauken
    Molecular and Cellular Biology Program, Department of Biology, Arizona State University, Tempe, Arizona, 85287 1501, USA
    Dev Biol 223:411-21. 2000
    ..Two isotypes have a stage-dependent nuclear localization. In addition, within each blastomere PKC isotypes occupy different subcellular locations in a stage-dependent fashion...
  58. pmc Absence of thyroid hormone activation during development underlies a permanent defect in adaptive thermogenesis
    Jessica A Hall
    Biological and Biomedical Sciences Program, Harvard Medical School, Boston, Massachusetts 02115, USA
    Endocrinology 151:4573-82. 2010
    ..This discovery highlights the importance of deiodinase-controlled thyroid hormone signaling in BAT development, where it has important metabolic repercussions for energy homeostasis in adulthood...
  59. pmc Protein kinase D controls the integrity of Golgi apparatus and the maintenance of dendritic arborization in hippocampal neurons
    Katalin Czöndör
    Department of Physiology and Neurobiology, Eotvos Lorand University, Budapest, Hungary H 1117
    Mol Biol Cell 20:2108-20. 2009
    b>Protein kinase D (PKD) is known to participate in various cellular functions, including secretory vesicle fission from the Golgi and plasma membrane-directed transport...
  60. pmc Protein kinase C-theta is specifically localized on centrosomes and kinetochores in mitotic cells
    M Passalacqua
    Institute of Biological Chemistry, University of Genoa, Viale Benedetto XV, 1 16132 Genoa, Italy
    Biochem J 337:113-8. 1999
    ..We propose that, unlike other members of the PKC family, PKC-straight theta may play a role in cell proliferation...
  61. doi Protein kinase D stabilizes aldosterone-induced ERK1/2 MAP kinase activation in M1 renal cortical collecting duct cells to promote cell proliferation
    Victoria McEneaney
    Department of Molecular Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland
    J Steroid Biochem Mol Biol 118:18-28. 2010
    ..Aldosterone promoted the proliferative growth of M1-CCD cells, an effect that was protein kinase D1 (PKD1), PKCdelta and ERK1/2-dependent...
  62. pmc Molecular cloning and characterization of protein kinase D: a target for diacylglycerol and phorbol esters with a distinctive catalytic domain
    A M Valverde
    Imperial Cancer Research Fund, London, United Kingdom
    Proc Natl Acad Sci U S A 91:8572-6. 1994
    A serine/threonine protein kinase that binds phorbol esters and diacylglycerol (named protein kinase D, PKD) has been identified...
  63. pmc Protein kinase D1 is essential for the proinflammatory response induced by hypersensitivity pneumonitis-causing thermophilic actinomycetes Saccharopolyspora rectivirgula
    Young In Kim
    Children s Foundation Research Center at Le Bonheur Children s Medical Center, Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN 38103, USA
    J Immunol 184:3145-56. 2010
    ..In the current study, we found that S. rectivirgula induces the activation of protein kinase D (PKD)1 in lung cells in vitro and in vivo. Activation of PKD1 by S. rectivirgula was dependent on MyD88...
  64. pmc Activation of mGluR5 induces rapid and long-lasting protein kinase D phosphorylation in hippocampal neurons
    Dilja D Krueger
    Howard Hughes Medical Institute, Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, 43 Vassar St, 46 3301, Cambridge, MA 02139, USA
    J Mol Neurosci 42:1-8. 2010
    ..Here, we report that stimulation of mGluR5 in hippocampal cultures and slices results in phosphorylation of protein kinase D (PKD) at the autophosphorylation site Ser-916...
  65. doi Protein kinase D1 modulates aldosterone-induced ENaC activity in a renal cortical collecting duct cell line
    Victoria McEneaney
    Department of Molecular Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Smurfit Building, Beaumont Hospital, Dublin 9, Ireland
    Mol Cell Endocrinol 325:8-17. 2010
    ..b>PKD1-suppressed cells constitutively expressed ENaCalpha at low abundance, with no increase after aldosterone treatment...
  66. ncbi A phorbol ester receptor/protein kinase, nPKC eta, a new member of the protein kinase C family predominantly expressed in lung and skin
    S Osada
    Department of Molecular Biology, Tokyo Metropolitan Institute of Medical Science, Japan
    J Biol Chem 265:22434-40. 1990
    ..These results clearly demonstrate the existence and the possible importance of nPKC eta as a member of the phorbol ester receptor/protein kinase, PKC, family...
  67. doi Postprandial activation of protein kinase Cµ regulates the expression of adipocytokines via the transcription factor AP-2β
    Motoyuki Kondo
    Division of Endocrinology and Metabolism, Department of Medicine, Shiga University of Medical Science, Seta, Tsukinowa cho, Otsu, Shiga 520 2192, Japan
    Int J Mol Med 28:95-100. 2011
    ..Finally, PKCµ could not activate a mutant MCP-1 promoter lacking the AP-2β binding domain. Our results suggest that postprandial activation of PKCµ plays a role in disordered postprandial adipocytokine expression through AP-2β...
  68. doi Protein kinase D regulates the adiponectin gene expression through phosphorylation of AP-2: a common pathway to the ABCA1 gene regulation
    Noriyuki Iwamoto
    Nagoya City University Graduate School of Medical Sciences, Kawasumi 1, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Atherosclerosis 216:90-6. 2011
    ..We therefore investigated the involvement of PKD in regulation of the adiponectin gene expression...
  69. pmc Protein kinase D orchestrates the activation of DRAK2 in response to TCR-induced Ca2+ influx and mitochondrial reactive oxygen generation
    Ryan H Newton
    Institute for Immunology, University of California, Irvine, Irvine, CA 92697, USA
    J Immunol 186:940-50. 2011
    ..Blockade of DRAK2 activity with the protein kinase D (PKD) inhibitor Gö6976 or expression of a kinase-dead PKD mutant prevented activation of DRAK2, whereas a ..
  70. pmc Ultraviolet B irradiation and activation of protein kinase D in primary mouse epidermal keratinocytes
    S N Arun
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA, USA
    Oncogene 30:1586-96. 2011
    Our previous studies demonstrated that protein kinase D (PKD), a serine/threonine kinase implicated in various cell processes, is upregulated in basal cell carcinoma (BCC), supporting a possible tumorigenic role for PKD in skin...
  71. pmc M3-muscarinic receptor promotes insulin release via receptor phosphorylation/arrestin-dependent activation of protein kinase D1
    Kok Choi Kong
    Department of Cell Physiology and Pharmacology, and Biomedical Services Division, University of Leicester, Leicester LE1 9HN, United Kingdom
    Proc Natl Acad Sci U S A 107:21181-6. 2010
    ....
  72. pmc Protein kinase D1 mediates stimulation of DNA synthesis and proliferation in intestinal epithelial IEC-18 cells and in mouse intestinal crypts
    James Sinnett-Smith
    Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine, CURE Digestive Diseases Research Center and Molecular Biology Institute, University of California, Los Angeles, California 90095, USA
    J Biol Chem 286:511-20. 2011
    We examined whether protein kinase D1 (PKD1), the founding member of a new protein kinase family, plays a critical role in intestinal epithelial cell proliferation...
  73. pmc Unique functions for protein kinase D1 and protein kinase D2 in mammalian cells
    Sharon A Matthews
    Ninewells Hospital, University of Dundee, Scotland, UK
    Biochem J 432:153-63. 2010
    Mammalian PKD (protein kinase D) isoforms have been implicated in the regulation of diverse biological processes in response to diacylglycerol and PKC (protein kinase C) signalling...