Gene Symbol: Prkcg
Description: protein kinase C, gamma
Alias: PKCgamma, Pkcc, Prkcc, protein kinase C gamma type, PKC-gamma
Species: mouse
Products:     Prkcg

Top Publications

  1. Pauken C, Capco D. The expression and stage-specific localization of protein kinase C isotypes during mouse preimplantation development. Dev Biol. 2000;223:411-21 pubmed
    ..Two isotypes have a stage-dependent nuclear localization. In addition, within each blastomere PKC isotypes occupy different subcellular locations in a stage-dependent fashion. ..
  2. Imamura T, Huang J, Usui I, Satoh H, Bever J, Olefsky J. Insulin-induced GLUT4 translocation involves protein kinase C-lambda-mediated functional coupling between Rab4 and the motor protein kinesin. Mol Cell Biol. 2003;23:4892-900 pubmed
  3. McNamara R, Lenox R. Acute restraint stress reduces protein kinase C gamma in the hippocampus of C57BL/6 but not DBA/2 mice. Neurosci Lett. 2004;368:293-6 pubmed
    Protein kinase C gamma (PKC gamma) is highly expressed in the rodent hippocampus and has been implicated in long-term alterations in synaptic efficacy...
  4. Shimobayashi E, Wagner W, Kapfhammer J. Carbonic Anhydrase 8 Expression in Purkinje Cells Is Controlled by PKCγ Activity and Regulates Purkinje Cell Dendritic Growth. Mol Neurobiol. 2016;53:5149-60 pubmed publisher
    ..Our results indicate that CA8 is a novel important regulator of Purkinje cell dendritic development and that its expression is controlled by PKCγ activity. ..
  5. Shutoh F, Katoh A, Ohki M, Itohara S, Tonegawa S, Nagao S. Role of protein kinase C family in the cerebellum-dependent adaptive learning of horizontal optokinetic response eye movements in mice. Eur J Neurosci. 2003;18:134-42 pubmed
    ..To reveal the functional differences of PKC subtypes, we examined the adaptability of ocular reflexes of PKCgamma mutant mice, which show mild ataxia and normal LTD...
  6. Gardell L, Ibrahim M, Wang R, Wang Z, Ossipov M, Malan T, et al. Mouse strains that lack spinal dynorphin upregulation after peripheral nerve injury do not develop neuropathic pain. Neuroscience. 2004;123:43-52 pubmed
    ..A null mutation of the gamma isoform of protein kinase C (PKCgamma KO [knockout]), as well as an inbred mouse strain, 129S6, also does not manifest behavioral signs of neuropathic ..
  7. Viveiros M, O Brien M, Eppig J. Protein kinase C activity regulates the onset of anaphase I in mouse oocytes. Biol Reprod. 2004;71:1525-32 pubmed
    ..Similarly, failure to regulate PKC activity at the preovulatory stage likely promotes arrest at MI. ..
  8. Darlington T, McCarthy R, Cox R, Miyamoto Ditmon J, Gallego X, Ehringer M. Voluntary wheel running reduces voluntary consumption of ethanol in mice: identification of candidate genes through striatal gene expression profiling. Genes Brain Behav. 2016;15:474-90 pubmed publisher
    ..interaction between ethanol consumption and wheel running include multiple potassium channel genes, Oprm1, Prkcg, Stxbp1, Crhr1, Gabra3, Slc6a13, Stx1b, Pomc, Rassf5 and Camta2...
  9. Gillespie C, Lee M, Fantes J, Brophy P. The gene encoding the Schwann cell protein periaxin localizes on mouse chromosome 7 (Prx). Genomics. 1997;41:297-8 pubmed

More Information

Publications102 found, 100 shown here

  1. Bowers B, Owen E, Collins A, Abeliovich A, Tonegawa S, Wehner J. Decreased ethanol sensitivity and tolerance development in gamma-protein kinase C null mutant mice is dependent on genetic background. Alcohol Clin Exp Res. 1999;23:387-97 pubmed
    ..These results stress the importance of including the effect of genetic background when evaluating the effects of single gene mutations on quantitative behavioral traits. ..
  2. Okuma Y, Murayama T, Tha K, Yamada C, Hosokawa M, Ishikawa A, et al. Learning deficiency and alterations in acetylcholine receptors and protein kinase C in the brain of senescence-accelerated mouse (SAM)-P10. Mech Ageing Dev. 2000;114:191-9 pubmed
    ..Thus, a reduction of mACh receptors and protein kinase C in the brain seems to underlie dysfunction of learning and memory in SAMP10. ..
  3. Bae S, Choi J, Oh Y, Yun S, Ryu S, Suh P. Regulation of phospholipase C-gamma1 by protein kinase A-dependent phosphorylation. Adv Enzyme Regul. 2002;42:195-211 pubmed
  4. Halet G. PKC signaling at fertilization in mammalian eggs. Biochim Biophys Acta. 2004;1742:185-9 pubmed
    ..Here, I review the recent development of PKC research in mammalian fertilization and the evidence for a specific role for certain PKC isotypes in fertilization-induced egg activation. ..
  5. Rottkamp C, Lobur K, Wladyka C, Lucky A, O GORMAN S. Pbx3 is required for normal locomotion and dorsal horn development. Dev Biol. 2008;314:23-39 pubmed
    ..Loss of Pbx3 function thus leads to the incorrect specification of some glutamatergic neurons in the dorsal horn and alters the integration of peripheral sensation into the spinal circuitry regulating locomotion. ..
  6. Liu Q, Chen X, MacDonnell S, Kranias E, Lorenz J, Leitges M, et al. Protein kinase C{alpha}, but not PKC{beta} or PKC{gamma}, regulates contractility and heart failure susceptibility: implications for ruboxistaurin as a novel therapeutic approach. Circ Res. 2009;105:194-200 pubmed publisher
    Protein kinase (PK)Calpha, PKCbeta, and PKCgamma comprise the conventional PKC isoform subfamily, which is thought to regulate cardiac disease responsiveness...
  7. Ross S, McCord A, Jung C, Atan D, Mok S, Hemberg M, et al. Bhlhb5 and Prdm8 form a repressor complex involved in neuronal circuit assembly. Neuron. 2012;73:292-303 pubmed publisher
    ..These findings suggest that Prdm8 is an obligate partner of Bhlhb5, forming a repressor complex that directs neural circuit assembly in part through the precise regulation of Cadherin-11. ..
  8. Buitrago L, Bhavanasi D, Dangelmaier C, Manne B, Badolia R, Borgognone A, et al. Tyrosine phosphorylation on spleen tyrosine kinase (Syk) is differentially regulated in human and murine platelets by protein kinase C isoforms. J Biol Chem. 2013;288:29160-9 pubmed publisher
    ..This result indicates that PKC? is the isoform responsible for Syk negative regulation in human platelets. In conclusion, we have elucidated a novel pathway of Syk regulation by PKC? in human platelets. ..
  9. Eckert J, McCallum A, Mears A, Rumsby M, Cameron I, Fleming T. Relative contribution of cell contact pattern, specific PKC isoforms and gap junctional communication in tight junction assembly in the mouse early embryo. Dev Biol. 2005;288:234-47 pubmed
    ..Our data suggest that the dynamics of cell contact patterns coordinate the spatial organization of TJ formation via specific PKC signaling pathways during blastocyst biogenesis. ..
  10. Smith A, Bowers B, Radcliffe R, Wehner J. Microarray analysis of the effects of a gamma-protein kinase C null mutation on gene expression in striatum: a role for transthyretin in mutant phenotypes. Behav Genet. 2006;36:869-81 pubmed
    ..Ethanol treatment of mutants reversed the dramatic increase in transthyretin expression seen in naïve and control-diet treated mutants, but did not affect transthyretin expression in wild types. ..
  11. Niikura K, Kobayashi Y, Okutsu D, Furuya M, Kawano K, Maitani Y, et al. Implication of spinal protein kinase Cgamma isoform in activation of the mouse brain by intrathecal injection of the protein kinase C activator phorbol 12,13-dibutyrate using functional magnetic resonance imaging analysis. Neurosci Lett. 2008;433:6-10 pubmed publisher
    ..could change brain activation using a functional magnetic resonance imaging (fMRI) analysis in mice that lack the PKCgamma gene. The activation of spinal PKC by intrathecal (i.t...
  12. Rodríguez Muñoz M, de la Torre Madrid E, Sánchez Blázquez P, Wang J, Garzón J. NMDAR-nNOS generated zinc recruits PKCgamma to the HINT1-RGS17 complex bound to the C terminus of Mu-opioid receptors. Cell Signal. 2008;20:1855-64 pubmed publisher
    ..this study, we found that intracerebroventricular (icv) administration of morphine recruits PKC isoforms, mostly PKCgamma, to the MOR via the HINT1/RGSZ complex...
  13. Clements R, Turk R, Campbell K, Wright K. Dystroglycan Maintains Inner Limiting Membrane Integrity to Coordinate Retinal Development. J Neurosci. 2017;37:8559-8574 pubmed publisher
    ..These results demonstrate that disorganization of retinal circuit development is a likely contributor to visual dysfunction in patients with dystroglycanopathy. ..
  14. Abeliovich A, Chen C, Goda Y, Silva A, Stevens C, Tonegawa S. Modified hippocampal long-term potentiation in PKC gamma-mutant mice. Cell. 1993;75:1253-62 pubmed
    ..We propose that PKC gamma is not part of the molecular machinery that produces LTP but is a key regulatory component.
  15. Kimura T, Merritt A, Lock F, Eckert J, Fleming T, Garrod D. Desmosomal adhesiveness is developmentally regulated in the mouse embryo and modulated during trophectoderm migration. Dev Biol. 2012;369:286-97 pubmed publisher
    ..We demonstrate that modulation of desmosomal adhesion by PKC can regulate migration of trophectoderm. It appears that tissue stabilisation is one of several roles played by desmosomes in animal development. ..
  16. Zechner U, Scheel S, Hemberger M, Hopp M, Haaf T, Fundele R, et al. Characterization of the mouse Src homology 3 domain gene Sh3d2c on Chr 7 demonstrates coexpression with huntingtin in the brain and identifies the processed pseudogene Sh3d2c-ps1 on Chr 2. Genomics. 1998;54:505-10 pubmed
    ..Because huntingtin and Sh3d2c are coexpressed in most regions of the brain, it can be speculated that there is a link between the association of huntingtin/Sh3d2c and the pathogenesis of Huntington disease. ..
  17. Balasubramanian G, Amann J, Reddy C. Expression and activity of protein kinase C isoenzymes during normal and abnormal murine palate development. J Craniofac Genet Dev Biol. 2000;20:26-34 pubmed
    ..0, which gradually decreased through GD 14.5, whereas PKC betaI and PKC gamma were negligible throughout...
  18. Bowers B, Collins A, Tritto T, Wehner J. Mice lacking PKC gamma exhibit decreased anxiety. Behav Genet. 2000;30:111-21 pubmed
    To investigate the contribution of the PKC gamma isoform of protein kinase C (PKC) in neurochemical pathways regulating anxiety, mice lacking the gene encoding PKC gamma were tested with heterozygote and wild-type littermates in three ..
  19. Proctor W, Poelchen W, Bowers B, Wehner J, Messing R, Dunwiddie T. Ethanol differentially enhances hippocampal GABA A receptor-mediated responses in protein kinase C gamma (PKC gamma) and PKC epsilon null mice. J Pharmacol Exp Ther. 2003;305:264-70 pubmed
    ..effects of ethanol on GABA(A) receptor-mediated inhibitory postsynaptic currents (IPSCs) in mice lacking either PKCgamma (PKCgamma(-/-)) or PKCepsilon (PKCepsilon(-/-)) isozymes and compared the results to those from corresponding ..
  20. Sato S, Omori Y, Katoh K, Kondo M, Kanagawa M, Miyata K, et al. Pikachurin, a dystroglycan ligand, is essential for photoreceptor ribbon synapse formation. Nat Neurosci. 2008;11:923-31 pubmed publisher
    ..This may also advance our understanding of the molecular mechanisms underlying the retinal electrophysiological abnormalities observed in muscular dystrophy patients. ..
  21. Shim S, Kwan K, Li M, Lefebvre V, Sestan N. Cis-regulatory control of corticospinal system development and evolution. Nature. 2012;486:74-9 pubmed publisher
    ..These findings reveal that SOX transcription factors converge onto a cis-acting element of Fezf2 and form critical components of a regulatory network controlling the identity and connectivity of corticospinal neurons. ..
  22. Takanaga H, Mukai H, Shimakawa M, Konishi H, Kikkawa U, Koizumi T, et al. Functional characterization of the promoter region of the mouse protein kinase C gamma gene. FEBS Lett. 1995;368:276-8 pubmed
    ..from the cells transfected with various fusion constructs containing the 5'-flanking region of the mouse PKC gamma gene and CAT gene...
  23. Bowers B, Parham C, Sikela J, Wehner J. Isolation and sequence of a mouse brain cDNA coding for protein kinase C-gamma isozyme. Gene. 1993;123:263-5 pubmed
    ..Here, we report the cDNA sequence encoding mouse PKC-gamma isolated from a C57BL/6 brain cDNA library. The mouse and rat PKC-gamma nt and deduced amino acid sequences share 97 and 100% identity, respectively. ..
  24. Izumi Y, Hirata M, Hasuwa H, Iwamoto R, Umata T, Miyado K, et al. A metalloprotease-disintegrin, MDC9/meltrin-gamma/ADAM9 and PKCdelta are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. EMBO J. 1998;17:7260-72 pubmed
    ..These results suggest that MDC9 and PKCdelta are involved in the stimulus-coupled shedding of the proHB-EGF ectodomain. ..
  25. Koyama N, Kashimata M, Sakashita H, Sakagami H, Gresik E. EGF-stimulated signaling by means of PI3K, PLCgamma1, and PKC isozymes regulates branching morphogenesis of the fetal mouse submandibular gland. Dev Dyn. 2003;227:216-26 pubmed
    ..These findings indicate that signaling from the EGF receptor in the fetal mouse SMG varies with development and triggers stimulatory effects by means of ERK-1/2 and PI3K but inhibitory effects by means of PKC isozymes. ..
  26. Wang S, Lim G, Zeng Q, Sung B, Yang L, Mao J. Central glucocorticoid receptors modulate the expression and function of spinal NMDA receptors after peripheral nerve injury. J Neurosci. 2005;25:488-95 pubmed
    ..receiving intrathecal treatment with an interleukin-6 (IL-6) antiserum and in mice with protein kinase Cgamma (PKCgamma) knock-out...
  27. Tao H, Suzuki M, Kiyonari H, Abe T, Sasaoka T, Ueno N. Mouse prickle1, the homolog of a PCP gene, is essential for epiblast apical-basal polarity. Proc Natl Acad Sci U S A. 2009;106:14426-31 pubmed publisher
    ..Our results demonstrate a role for mpk1 in AB polarity formation rather than expected role as a PCP gene. ..
  28. Depienne C, Bouteiller D, Méneret A, Billot S, Groppa S, Klebe S, et al. RAD51 haploinsufficiency causes congenital mirror movements in humans. Am J Hum Genet. 2012;90:301-7 pubmed publisher
    ..These findings open a new field of investigation for researchers attempting to unravel the molecular pathways underlying bimanual motor control in humans...
  29. Qu Y, Huang Y, Feng J, Alvarez Bolado G, Grove E, Yang Y, et al. Genetic evidence that Celsr3 and Celsr2, together with Fzd3, regulate forebrain wiring in a Vangl-independent manner. Proc Natl Acad Sci U S A. 2014;111:E2996-3004 pubmed publisher
    ..Our results suggest that Celsr2-3 and Fzd3 regulate axonal navigation in the forebrain by using mechanisms different from classical epithelial PCP, and require interacting partners other than Vangl1-2 that remain to be identified. ..
  30. Narita M, Mizoguchi H, Khotib J, Suzuki M, Ozaki S, Yajima Y, et al. Influence of a deletion of protein kinase C gamma isoform in the G-protein activation mediated through opioid receptor-like-1 and mu-opioid receptors in the mouse pons/medulla. Neurosci Lett. 2002;331:5-8 pubmed was to investigate whether mice with a deletion of the gene that encodes the protein kinase C gamma (PKC gamma) isoform could affect the G-protein activation mediated through the opioid receptor-like (ORL-1) receptor and mu-..
  31. Seki T, Shimahara T, Yamamoto K, Abe N, Amano T, Adachi N, et al. Mutant gammaPKC found in spinocerebellar ataxia type 14 induces aggregate-independent maldevelopment of dendrites in primary cultured Purkinje cells. Neurobiol Dis. 2009;33:260-73 pubmed publisher
    ..These molecular properties of mutant gammaPKC might affect the dendritic morphology in PCs, and be involved in the pathogenesis of SCA14. ..
  32. Ross S, Mardinly A, McCord A, Zurawski J, Cohen S, Jung C, et al. Loss of inhibitory interneurons in the dorsal spinal cord and elevated itch in Bhlhb5 mutant mice. Neuron. 2010;65:886-98 pubmed publisher
    ..Our findings suggest that Bhlhb5 is required for the survival of a specific population of inhibitory interneurons that regulate pruritus, and provide evidence that the loss of inhibitory synaptic input results in abnormal itch. ..
  33. Vesterlund L, Tohonen V, Hovatta O, Kere J. Co-localization of neural cell adhesion molecule and fibroblast growth factor receptor 2 in early embryo development. Int J Dev Biol. 2011;55:313-9 pubmed publisher
    ..In summary these findings show a co-localization of NCAM and FGFR2 in early vertebrate development with intracellular signaling pathways present to enable a cellular response. ..
  34. Ikeda A, Miyazaki T, Kakizawa S, Okuno Y, Tsuchiya S, Myomoto A, et al. Abnormal features in mutant cerebellar Purkinje cells lacking junctophilins. Biochem Biophys Res Commun. 2007;363:835-9 pubmed
    ..Moreover, gene expression was slightly altered in the JP-DKO cerebellum. Therefore, the mutant PCs bear marginal but widespread abnormalities, all of which likely cause cerebellar motor defects in JP-DKO mice. ..
  35. Matsumoto S, Murozono M, Nagaoka D, Matsuoka S, Takeda A, Narita H, et al. Isoflurane inhibits protein kinase Cgamma and calcium/calmodulin dependent protein kinase ii-alpha translocation to synaptic membranes in ischemic mice brains. Neurochem Res. 2008;33:2302-9 pubmed publisher
    ..We thus tested a hypothesis that isoflurane inhibits PKCgamma and CaMKII-alpha translocation after ischemic brain insults...
  36. Nithianantharajah J, Murphy M. Experience on the Barnes spatial maze influences PKCgamma levels in the hippocampus. Int J Neurosci. 2009;119:1014-30 pubmed publisher
    ..examine hippocampal plasticity following spatial learning, expression of the gamma isoform of protein kinase C (PKCgamma) was analyzed in mice, following experience and training on the Barnes spatial maze...
  37. Akimoto K, Mizuno K, Osada S, Hirai S, Tanuma S, Suzuki K, et al. A new member of the third class in the protein kinase C family, PKC lambda, expressed dominantly in an undifferentiated mouse embryonal carcinoma cell line and also in many tissues and cells. J Biol Chem. 1994;269:12677-83 pubmed
    ..These results, in conjunction with the results obtained in parallel experiments with PKC zeta and other PKC members, suggest a biochemical similarity between PKC lambda and zeta and their clear difference from other PKC members...
  38. Pinzon Guzman C, Zhang S, Barnstable C. Specific protein kinase C isoforms are required for rod photoreceptor differentiation. J Neurosci. 2011;31:18606-17 pubmed publisher
    ..These data unveil a novel signaling cascade that coordinates and regulates rod differentiation through specific PKC isoforms in mammals. ..
  39. Kim J, Ashworth L, Branscomb E, Stubbs L. The human homolog of a mouse-imprinted gene, Peg3, maps to a zinc finger gene-rich region of human chromosome 19q13.4. Genome Res. 1997;7:532-40 pubmed
    ..4 and mouse chromosome 7. ..
  40. Woo C, Lim J, Kim J. Lipopolysaccharide induces matrix metalloproteinase-9 expression via a mitochondrial reactive oxygen species-p38 kinase-activator protein-1 pathway in Raw 264.7 cells. J Immunol. 2004;173:6973-80 pubmed
    ..Finally, we showed that the ROS-p38 kinase cascade targets the transcription factor AP-1. Taken together, our findings identify a ROS-p38 kinase-AP-1 cascade as a novel pathway mediating LPS signaling to MMP-9 expression in macrophages. ..
  41. Zhang L, Abraham D, Lin S, Oster H, Eichele G, Fu Y, et al. PKC? participates in food entrainment by regulating BMAL1. Proc Natl Acad Sci U S A. 2012;109:20679-84 pubmed publisher
    ..Taken together, these results suggest that PKC? plays a role in food entrainment by regulating BMAL1 stability. ..
  42. Celerier E, Simonnet G, Maldonado R. Prevention of fentanyl-induced delayed pronociceptive effects in mice lacking the protein kinase Cgamma gene. Neuropharmacology. 2004;46:264-72 pubmed
    ..Events upstream of the NMDA receptor, especially the activation of the protein kinase Cgamma (PKCgamma), have been involved in the persistence of pain states associated with central sensitisation...
  43. Schmitz Peiffer C. The tail wagging the dog--regulation of lipid metabolism by protein kinase C. FEBS J. 2013;280:5371-83 pubmed publisher
    ..Although PKCs may inhibit insulin signal transduction, these enzymes are not merely downstream effectors of lipid accumulation, but in fact control the fate of fatty acids, thus the tail wags the dog. ..
  44. Passalacqua M, Patrone M, Sparatore B, Melloni E, Pontremoli S. Protein kinase C-theta is specifically localized on centrosomes and kinetochores in mitotic cells. Biochem J. 1999;337 ( Pt 1):113-8 pubmed
    ..We propose that, unlike other members of the PKC family, PKC-straight theta may play a role in cell proliferation. ..
  45. Hix D, Bowers B, Miyamoto J, Wehner J. Open field activity and EtOH activation of gamma-PKC null mutants. Addict Biol. 2003;8:399-412 pubmed
    ..This reflects the pleiotropic effects of the gamma-PKC null mutation on the behavioral effects of ethanol. ..
  46. Steinberg S. Distinctive activation mechanisms and functions for protein kinase Cdelta. Biochem J. 2004;384:449-59 pubmed
    ..Collectively, these studies argue that the conventional model for PKCdelta activation must be broadened to allow for stimulus-specific differences in PKCdelta signalling during growth factor stimulation and oxidant stress. ..
  47. Szabo N, Da Silva R, Sotocinal S, Zeilhofer H, Mogil J, Kania A. Hoxb8 intersection defines a role for Lmx1b in excitatory dorsal horn neuron development, spinofugal connectivity, and nociception. J Neurosci. 2015;35:5233-46 pubmed publisher
    ..Together, our results demonstrate an important role for the intersection of Lmx1b and Hoxb8::cre expression in the development of nociceptive dorsal horn circuits critical for mechanical and thermal pain processing. ..
  48. Narita M, Aoki T, Ozaki S, Yajima Y, Suzuki T. Involvement of protein kinase Cgamma isoform in morphine-induced reinforcing effects. Neuroscience. 2001;103:309-14 pubmed
    ..The protein level of PKCgamma was significantly up-regulated in membrane preparations of the limbic forebrain obtained from the morphine-..
  49. Jardemark K, Ninan I, Liang X, Wang R. Protein kinase C is involved in clozapine's facilitation of N-methyl-D-aspartate- and electrically evoked responses in pyramidal cells of the medial prefrontal cortex. Neuroscience. 2003;118:501-12 pubmed
    ..To further test the role of PKC in mediating the augmenting action of clozapine, we performed experiments in PKCgamma mutant and wild-type mice...
  50. Wang Q, Lu G, Schlapkohl W, Goerke A, Larsson C, Mischak H, et al. The V5 domain of protein kinase C plays a critical role in determining the isoform-specific localization, translocation, and biological function of protein kinase C-delta and -epsilon. Mol Cancer Res. 2004;2:129-40 pubmed
    ..Thus, the V5 domain is critical in several of the isozyme-specific functions of PKC-delta and -epsilon. ..
  51. DeVries T, Kalkofen R, Matassa A, Reyland M. Protein kinase Cdelta regulates apoptosis via activation of STAT1. J Biol Chem. 2004;279:45603-12 pubmed
    ..Our data identify STAT1 as a downstream target of PKCdelta and suggest that PKCdelta may regulate apoptosis by activation of STAT1 target genes. ..
  52. Takahashi N, Shuvaev A, Konno A, Matsuzaki Y, Watanave M, Hirai H. Regulatory connection between the expression level of classical protein kinase C and pruning of climbing fibers from cerebellar Purkinje cells. J Neurochem. 2017;143:660-670 pubmed publisher
    ..Although both PKC? and PKC? are capable of pruning supernumerary CF synapses from developing PCs, these results suggest that the expression levels of cPKCs in PKC? KO PCs are too low for CF pruning. ..
  53. Chen Z, Rebelo S, White F, Malmberg A, Baba H, Lima D, et al. The paired homeodomain protein DRG11 is required for the projection of cutaneous sensory afferent fibers to the dorsal spinal cord. Neuron. 2001;31:59-73 pubmed
    ..Drg11 is thus required for the formation of spatio-temporally appropriate projections from nociceptive sensory neurons to their central targets in the dorsal horn of the spinal cord. ..
  54. Wouters M, Roeder J, Tharayil V, Stanich J, Strege P, Lei S, et al. Protein kinase C{gamma} mediates regulation of proliferation by the serotonin 5-hydroxytryptamine receptor 2B. J Biol Chem. 2009;284:21177-84 pubmed publisher
    ..Of all the PKC isoforms blocked by Gö6976, PKCgamma and micro mRNAs were found by single-cell PCR to be expressed in ICC...
  55. Kou Z, Zhang Y, Zhang T, Li H, Li Y. Age-related increase in PKC gamma expression in the cochlear nucleus of hearing impaired C57BL/6J and BALB/c mice. J Chem Neuroanat. 2011;41:20-4 pubmed publisher
    ..05). Thus our findings demonstrate a potential link between the increased PKC? expression and the age-related hearing loss in these mice, suggesting novel strategies for the prevention and therapy of age-associated auditory disorders. ..
  56. Zhang Q, Wang D, Singh N, Kundumani Sridharan V, Gadiparthi L, Rao C, et al. Activation of cytosolic phospholipase A2 downstream of the Src-phospholipase D1 (PLD1)-protein kinase C ? (PKC?) signaling axis is required for hypoxia-induced pathological retinal angiogenesis. J Biol Chem. 2011;286:22489-98 pubmed publisher
    ..These observations suggest that cPLA(2)-dependent AA release is required for VEGF-induced Src-PLD1-PKC?-mediated pathological retinal angiogenesis. ..
  57. Shuvaev A, Horiuchi H, Seki T, Goenawan H, Irie T, Iizuka A, et al. Mutant PKC? in spinocerebellar ataxia type 14 disrupts synapse elimination and long-term depression in Purkinje cells in vivo. J Neurosci. 2011;31:14324-34 pubmed publisher
  58. Shirafuji T, Ueyama T, Yoshino K, Takahashi H, Adachi N, Ago Y, et al. The role of Pak-interacting exchange factor-? phosphorylation at serines 340 and 583 by PKC? in dopamine release. J Neurosci. 2014;34:9268-80 pubmed publisher
    ..Therefore, we propose that PKC? positively modulates dopamine release through ?2PIX phosphorylation. The PKC?-?PIX-Cdc42/Rac1 phosphorylation axis may provide a new therapeutic target for the treatment of parkinsonian syndrome. ..
  59. Ramakers G, Gerendasy D, de Graan P. Substrate phosphorylation in the protein kinase Cgamma knockout mouse. J Biol Chem. 1999;274:1873-4 pubmed
  60. Barton P, Mullen A, Cullen M, Dhoot G, Simon Chazottes D, Guenet J. Genes encoding troponin I and troponin T are organized as three paralogous pairs in the mouse genome. Mamm Genome. 2000;11:926-9 pubmed
  61. Avazeri N, Courtot A, Lefevre B. Regulation of spontaneous meiosis resumption in mouse oocytes by various conventional PKC isozymes depends on cellular compartmentalization. J Cell Sci. 2004;117:4969-78 pubmed
    ..Further investigations are however necessary to discover the molecular targets of these cPKCs to better understand the links with the cell cycle progression. ..
  62. Zheng Z, Li Q, Chen D, Schatten H, Sun Q. Translocation of phospho-protein kinase Cs implies their roles in meiotic-spindle organization, polar-body emission and nuclear activity in mouse eggs. Reproduction. 2005;129:229-34 pubmed
    ..The results suggest that PKC activation may play important roles in regulating spindle organization and stabilization, polar-body extrusion, and nuclear activity during mouse oocyte meiosis, fertilization, and early embryonic mitosis. ..
  63. Kelher M, McLaughlin N, Banerjee A, Elzi D, Gamboni F, Khan S, et al. LysoPCs induce Hck- and PKC?-mediated activation of PKC? causing p47phox phosphorylation and membrane translocation in neutrophils. J Leukoc Biol. 2017;101:261-273 pubmed publisher
    ..We conclude that lysoPCs prime PMNs through Hck-dependent activation of PKC?, which stimulates PKC?, resulting in translocation of phosphorylated p47phox. ..
  64. Palmer S, Perry J, Ashworth A. A contravention of Ohno's law in mice. Nat Genet. 1995;10:472-6 pubmed
    ..The consequence of this chromosomal rearrangement is that the gene is lost by mendelian segregation in a subset of the male progeny of a (C57BL/6 x Mus spretus) x Mus spretus backcross. ..
  65. Xiaoping G, Xiaofang Z, Yaguo Z, Juan Z, Junhua W, Zhengliang M. Involvement of the spinal NMDA receptor/PKC? signaling pathway in the development of bone cancer pain. Brain Res. 2010;1335:83-90 pubmed publisher
    ..It has been shown that spinal NMDA receptor-dependent activation of PKCgamma facilitates nociception during neuropathic and inflammatory pain, but its involvement in bone cancer pain has not ..
  66. Yu J, Halder D, Baek M, Das N, Choi M, Oh D, et al. Changes in the expression of transthyretin and protein kinase C? genes in the prefrontal cortex in response to naltrexone. Neurosci Lett. 2011;488:288-93 pubmed publisher
    ..These findings provide a basis for conducting pharmacogenetic research on the effect of naltrexone in specific brain areas, which would enhance our understanding of the underlying causes and possible treatments of alcohol use disorders. ..
  67. Walser R, Burke J, Gogvadze E, Bohnacker T, Zhang X, Hess D, et al. PKC? phosphorylates PI3K? to activate it and release it from GPCR control. PLoS Biol. 2013;11:e1001587 pubmed publisher
    ..Our data show that the interaction of p110? with its adapter subunit is vulnerable to phosphorylation, and outline a novel level of PI3K control. ..
  68. Mandai K, Reimert D, Ginty D. Linx mediates interaxonal interactions and formation of the internal capsule. Neuron. 2014;83:93-103 pubmed publisher
    ..Thus, Linx guides the extension of thalamocortical axons in the ventral forebrain, and subsequently, it mediates reciprocal interactions between thalamocortical and corticofugal axons to form the IC. ..
  69. Takahashi H, Adachi N, Shirafuji T, Danno S, Ueyama T, Vendruscolo M, et al. Identification and characterization of PKCγ, a kinase associated with SCA14, as an amyloidogenic protein. Hum Mol Genet. 2015;24:525-39 pubmed publisher
    ..More generally, our results provide novel insights into the mechanism of amyloid-like fibril formation by multi-domain proteins. ..
  70. Watson M, Rao J, Gilkeson G, Ruiz P, Eicher E, Pisetsky D, et al. Genetic analysis of MRL-lpr mice: relationship of the Fas apoptosis gene to disease manifestations and renal disease-modifying loci. J Exp Med. 1992;176:1645-56 pubmed
    ..Moreover, this study provides a model for dissecting the complex genetic interactions that result in manifestations of autoimmune disease. ..
  71. Saunders A, Seldin M. The syntenic relationship of proximal mouse chromosome 7 and the myotonic dystrophy gene region on human chromosome 19q. Genomics. 1990;6:324-32 pubmed
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