Prkce

Summary

Gene Symbol: Prkce
Description: protein kinase C, epsilon
Alias: 5830406C15Rik, PKC[e], PKCepsilon, Pkce, R75156, protein kinase C epsilon type, nPKC-epsilon
Species: mouse

Top Publications

  1. doi Selective activation of protein kinase C-delta and -epsilon by 6,11,12,14-tetrahydroxy-abieta-5,8,11,13-tetraene-7-one (coleon U)
    I Coutinho
    Laboratorio de Microbiologia, REQUIMTE CEQUP, Faculdade de Farmacia, Universidade do Porto, Rua Anibal Cunha, 164, 4050 047 Porto, Portugal
    Biochem Pharmacol 78:449-59. 2009
  2. pmc Protein kinase C isoforms epsilon, eta, delta and zeta in murine adipocytes: expression, subcellular localization and tissue-specific regulation in insulin-resistant states
    E U Frevert
    Department of Medicine, Beth Israel Hospital, Harvard Medical School, Boston, MA 02215, USA
    Biochem J 316:865-71. 1996
  3. ncbi A novel nociceptor signaling pathway revealed in protein kinase C epsilon mutant mice
    S G Khasar
    Department of Internal Medicine and Oral Surgery, National Institutes of Health University of California, USA
    Neuron 24:253-60. 1999
  4. ncbi Protein kinase C-epsilon transgenic mice: a unique model for metastatic squamous cell carcinoma
    A P Jansen
    Department of Human Oncology, Medical School, University of Wisconsin, Madison, 53792, USA
    Cancer Res 61:808-12. 2001
  5. pmc Protein kinase Cepsilon is required for macrophage activation and defense against bacterial infection
    A Castrillo
    Instituto de Bioquímica Centro Mixto Consejo Superior de Investigaciones Cientificas UCM, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain
    J Exp Med 194:1231-42. 2001
  6. ncbi Inhibition of glycogen synthesis by fatty acid in C(2)C(12) muscle cells is independent of PKC-alpha, -epsilon, and -theta
    R Cazzolli
    Garvan Institute of Medical Research, Sydney, New South Wales 2010, Australia
    Am J Physiol Endocrinol Metab 282:E1204-13. 2002
  7. ncbi Protein kinase C epsilon: a new target to control inflammation and immune-mediated disorders
    Ezra Aksoy
    Laboratory of Experimental Immunology, Universite Libre de Bruxelles, B 1070, Brussels, Belgium
    Int J Biochem Cell Biol 36:183-8. 2004
  8. ncbi Phorbol ester-induced translocation of PKC epsilon to the nucleus in fibroblasts: identification of nuclear PKC epsilon-associating proteins
    Tian Rui Xu
    Department of Biology, University of York, York YO10 5DD, UK
    FEBS Lett 570:20-4. 2004
  9. ncbi Protein kinase Cepsilon is dispensable for TCR/CD3-signaling
    Thomas Gruber
    Department for Medical Biology and Human Genetics, Medical University of Innsbruck, Schoepfstrasse 41, A 6020 Innsbruck, Austria
    Mol Immunol 42:305-10. 2005
  10. ncbi Increased collagen deposition and diastolic dysfunction but preserved myocardial hypertrophy after pressure overload in mice lacking PKCepsilon
    Gunnar Klein
    Department of Cardiovascular Medicine, Hannover Medical School, Germany
    Circ Res 96:748-55. 2005

Scientific Experts

Detail Information

Publications122 found, 100 shown here

  1. doi Selective activation of protein kinase C-delta and -epsilon by 6,11,12,14-tetrahydroxy-abieta-5,8,11,13-tetraene-7-one (coleon U)
    I Coutinho
    Laboratorio de Microbiologia, REQUIMTE CEQUP, Faculdade de Farmacia, Universidade do Porto, Rua Anibal Cunha, 164, 4050 047 Porto, Portugal
    Biochem Pharmacol 78:449-59. 2009
    ....
  2. pmc Protein kinase C isoforms epsilon, eta, delta and zeta in murine adipocytes: expression, subcellular localization and tissue-specific regulation in insulin-resistant states
    E U Frevert
    Department of Medicine, Beth Israel Hospital, Harvard Medical School, Boston, MA 02215, USA
    Biochem J 316:865-71. 1996
    ..We conclude that, although none of the isoforms investigated seems to be activated by insulin, the decrease in PKC-epsilon expression might contribute to metabolic alterations in adipocytes associated with insulin resistance and obesity...
  3. ncbi A novel nociceptor signaling pathway revealed in protein kinase C epsilon mutant mice
    S G Khasar
    Department of Internal Medicine and Oral Surgery, National Institutes of Health University of California, USA
    Neuron 24:253-60. 1999
    ..mechanical and thermal hyperalgesia and acetic acid-associated hyperalgesia are markedly attenuated in PKCepsilon mutant mice, but baseline nociceptive thresholds are normal...
  4. ncbi Protein kinase C-epsilon transgenic mice: a unique model for metastatic squamous cell carcinoma
    A P Jansen
    Department of Human Oncology, Medical School, University of Wisconsin, Madison, 53792, USA
    Cancer Res 61:808-12. 2001
    ..FVB/N transgenic mice, which overexpress (approximately 18-fold) epitope-tagged protein kinase C-epsilon (T7-PKCepsilon) protein in the epidermis provide a unique murine model system for highly malignant/metastatic SCC...
  5. pmc Protein kinase Cepsilon is required for macrophage activation and defense against bacterial infection
    A Castrillo
    Instituto de Bioquímica Centro Mixto Consejo Superior de Investigaciones Cientificas UCM, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain
    J Exp Med 194:1231-42. 2001
    ..kinase C (PKC)epsilon in the immune system, we generated mice that carried a homozygous disruption of the PKCepsilon locus...
  6. ncbi Inhibition of glycogen synthesis by fatty acid in C(2)C(12) muscle cells is independent of PKC-alpha, -epsilon, and -theta
    R Cazzolli
    Garvan Institute of Medical Research, Sydney, New South Wales 2010, Australia
    Am J Physiol Endocrinol Metab 282:E1204-13. 2002
    ..We conclude that neither mitochondrial lipid metabolism nor activation of PKC-alpha, -epsilon, or -theta plays a role in the direct inhibition of glycogen synthesis by unsaturated fatty acids...
  7. ncbi Protein kinase C epsilon: a new target to control inflammation and immune-mediated disorders
    Ezra Aksoy
    Laboratory of Experimental Immunology, Universite Libre de Bruxelles, B 1070, Brussels, Belgium
    Int J Biochem Cell Biol 36:183-8. 2004
    ..Thus, controlling the kinase activity of PKC epsilon might represent an efficient strategy to prevent or treat certain inflammatory disorders of microbial origin...
  8. ncbi Phorbol ester-induced translocation of PKC epsilon to the nucleus in fibroblasts: identification of nuclear PKC epsilon-associating proteins
    Tian Rui Xu
    Department of Biology, University of York, York YO10 5DD, UK
    FEBS Lett 570:20-4. 2004
    ..We have confirmed that these proteins associate with PKC by gel overlay and/or dot blotting assays. The role of these PKC-associating proteins in the nucleus and their interaction with PKC are considered...
  9. ncbi Protein kinase Cepsilon is dispensable for TCR/CD3-signaling
    Thomas Gruber
    Department for Medical Biology and Human Genetics, Medical University of Innsbruck, Schoepfstrasse 41, A 6020 Innsbruck, Austria
    Mol Immunol 42:305-10. 2005
    b>PKCepsilon has been strongly linked to cell activation and proliferation in many cell types, including leukemic T-cell lines...
  10. ncbi Increased collagen deposition and diastolic dysfunction but preserved myocardial hypertrophy after pressure overload in mice lacking PKCepsilon
    Gunnar Klein
    Department of Cardiovascular Medicine, Hannover Medical School, Germany
    Circ Res 96:748-55. 2005
    Overexpression and activation of protein kinase C-epsilon (PKCepsilon) results in myocardial hypertrophy. However, these observations do not establish that PKCepsilon is required for the development of myocardial hypertrophy...
  11. ncbi Cross-desensitization among CXCR1, CXCR2, and CCR5: role of protein kinase C-epsilon
    Mohd W Nasser
    Julius L Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, 27707, USA
    J Immunol 174:6927-33. 2005
    ..induced time-dependent association of PKCalpha, -beta1, and -beta2 to the membrane, but only CXCR1 activated PKCepsilon. CXCL8 also failed to activate PKCepsilon in RBL-2H3 cells stably expressing CXCR2...
  12. pmc PKCepsilon-mediated phosphorylation of vimentin controls integrin recycling and motility
    Johanna Ivaska
    VTT Technical Research Centre for Finland, Medical Biotechnology and University of Turku Centre for Biotechnology, Turku, Finland
    EMBO J 24:3834-45. 2005
    b>PKCepsilon controls the transport of endocytosed beta1-integrins to the plasma membrane regulating directional cell motility...
  13. ncbi A redundant role for PKC-epsilon in mast cell signaling and effector function
    Eva Lessmann
    Department of Molecular Immunology, Institute for Biology III, University of Freiburg and Max Planck Institute for Immunobiology, Stubeweg 51, 79108 Freiburg, Germany
    Int Immunol 18:767-73. 2006
    ..These results strongly suggest that PKC-epsilon plays a redundant role in MCs stimulated by antigen as well as other well-known MC stimuli...
  14. pmc Trif-related adapter molecule is phosphorylated by PKC{epsilon} during Toll-like receptor 4 signaling
    Anne F McGettrick
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    Proc Natl Acad Sci U S A 103:9196-201. 2006
    b>PKCepsilon has been shown to play a key role in the effect of the Gram-negative bacterial product LPS; however, the target for PKCepsilon in LPS signaling is unknown...
  15. ncbi Peptides derived from the C2 domain of protein kinase C epsilon (epsilon PKC) modulate epsilon PKC activity and identify potential protein-protein interaction surfaces
    Relly Brandman
    Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Biol Chem 282:4113-23. 2007
    ....
  16. ncbi Protein kinase C epsilon regulates gamma-aminobutyrate type A receptor sensitivity to ethanol and benzodiazepines through phosphorylation of gamma2 subunits
    Zhan Heng Qi
    Ernest Gallo Clinic and Research Center, Department of Neurology, University of California San Francisco, 5858 Horton Street, Emeryville, CA 94608, USA
    J Biol Chem 282:33052-63. 2007
    ..We postulated that the epsilon isoform of protein kinase C (PKCepsilon) regulates the ethanol sensitivity of GABA(A) receptors, as mice lacking PKCepsilon show an increased behavioral ..
  17. ncbi Amygdala protein kinase C epsilon regulates corticotropin-releasing factor and anxiety-like behavior
    H M B Lesscher
    Department of Neurology, Ernest Gallo Clinic and Research Center, University of California at San Francisco, Emeryville, CA 94608, USA
    Genes Brain Behav 7:323-33. 2008
    ..Here, we report that protein kinase C epsilon (PKCepsilon) null mutant mice, which show reduced anxiety-like behavior, have reduced levels of CRF messenger RNA and ..
  18. ncbi Inhibition of PKCepsilon improves glucose-stimulated insulin secretion and reduces insulin clearance
    Carsten Schmitz-Peiffer
    Garvan Institute of Medical Research, Sydney, NSW 2010, Australia
    Cell Metab 6:320-8. 2007
    ..Here we report a role for the lipid-regulated protein kinase C isoform PKCepsilon in beta cell dysfunction...
  19. doi The regulated assembly of a PKCepsilon complex controls the completion of cytokinesis
    Adrian T Saurin
    Protein Phosphorylation Laboratory, London Research Institute, Cancer Research UK, London, WC2A 3PX, UK
    Nat Cell Biol 10:891-901. 2008
    ..Specifically, we have identified three phosphorylation sites within PKCepsilon that control its association with 14-3-3...
  20. doi Loss of protein kinase Cepsilon results in impaired cutaneous wound closure and myofibroblast function
    Andrew Leask
    CIHR Group in Skeletal Development and Remodeling, Division of Oral Biology and Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London ON, Canada N6A 5C1
    J Cell Sci 121:3459-67. 2008
    ..In this report, we show that, compared with wild-type littermates, PKCepsilon-/- mice display delayed impaired cutaneous wound closure and a reduction in myofibroblasts...
  21. pmc Phorbol-12-myristate 13-acetate acting through protein kinase Cepsilon induces translocator protein (18-kDa) TSPO gene expression
    Amani Batarseh
    Department of Biochemistry and Molecular and Cell Biology, Georgetown University Medical Center, Washington, DC 20057, USA
    Biochemistry 47:12886-99. 2008
    ..blocked PMA induction of Tspo promoter activity with an inhibition profile suggestive of involvement of PKCepsilon. PKCepsilon expression correlated with TSPO content in the three cell lines...
  22. pmc Differential roles of the PKC novel isoforms, PKCdelta and PKCepsilon, in mouse and human platelets
    Catherine J Pears
    Department of Biochemistry, University of Oxford, Oxford, United Kingdom
    PLoS ONE 3:e3793. 2008
    ..Increasing evidence suggests that individual isoforms of protein kinase C (PKC) play distinct roles in regulating platelet activation...
  23. doi Opposite effects of protein kinase C beta1 (PKCbeta1) and PKCepsilon in the metastatic potential of a breast cancer murine model
    Valeria C Grossoni
    Research Area, Institute of Oncology Angel H Roffo, University of Buenos Aires, Av San Martin 5481, C1417DTB, Buenos Aires, Argentina
    Breast Cancer Res Treat 118:469-80. 2009
    In this paper we investigated whether protein kinase C (PKC) beta1 and PKCepsilon, members of the classical and novel PKC family, respectively, induce phenotypic alterations that could be associated with tumor progression and metastatic ..
  24. doi Diverse roles for protein kinase C delta and protein kinase C epsilon in the generation of high-fat-diet-induced glucose intolerance in mice: regulation of lipogenesis by protein kinase C delta
    G Frangioudakis
    Diabetes and Obesity Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, New South Wales, 2010, Australia
    Diabetologia 52:2616-20. 2009
    ..aimed to determine whether protein kinase C (PKC) delta plays a role in the glucose intolerance caused by a high-fat diet, and whether it could compensate for loss of PKCepsilon in the generation of insulin resistance in skeletal muscle.
  25. doi Time-dependent effects of Prkce deletion on glucose homeostasis and hepatic lipid metabolism on dietary lipid oversupply in mice
    K Raddatz
    Garvan Institute of Medical Research, 384 Victoria Street, Sydney, NSW 2010, Australia
    Diabetologia 54:1447-56. 2011
    We examined the time-dependent effects of deletion of the gene encoding protein kinase C epsilon (Prkce) on glucose homeostasis, insulin secretion and hepatic lipid metabolism in fat-fed mice.
  26. pmc Submaximal inhibition of protein kinase C restores ADP-induced dense granule secretion in platelets in the presence of Ca2+
    Amanda J Unsworth
    Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom
    J Biol Chem 286:21073-82. 2011
    ..These results also demonstrate isoform-specific inhibitory effects of PKC in platelets...
  27. pmc Protein kinase C isoform ε negatively regulates ADP-induced calcium mobilization and thromboxane generation in platelets
    Yamini S Bynagari-Settipalli
    Temple University School of Medicine, Philadelphia, PA 19140, USA
    Arterioscler Thromb Vasc Biol 32:1211-9. 2012
    ..We investigated the mechanism and specific isoforms involved in PKC-mediated negative regulation of ADP-induced functional responses...
  28. pmc Expression pattern of protein kinase C ϵ during mouse embryogenesis
    Sergio Carracedo
    Biotechnology Centre of Oslo, University of Oslo, Gaustadalleen 21, Oslo, N 0349, Norway
    BMC Dev Biol 13:16. 2013
    ..In this study, we contribute to expand the knowledge on PKCϵ by reporting its expression pattern during murine midgestation using the LacZ reporter gene and immunostaining procedures...
  29. ncbi Up-regulation of protein kinase C-epsilon promotes the expression of cytokine-inducible nitric oxide synthase in RAW 264.7 cells
    M J Diaz-Guerra
    Instituto de Bioquímica Consejo Superior de Investigaciones Cientifícas, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain
    J Biol Chem 271:32028-33. 1996
    ..These results suggest that PKC-epsilon can regulate a pathway that promotes iNOS expression in macrophages in response to phorbol ester activation...
  30. ncbi Regulation of tumor invasion and metastasis in protein kinase C epsilon-transformed NIH3T3 fibroblasts
    Souvenir D Tachado
    Department of Anatomy and Cell Biology, Brody School of Medicine at East Carolina University, Greenville, North Carolina 27858, USA
    J Cell Biochem 85:785-97. 2002
    ..Cells constitutively expressing PKCepsilon spontaneously acquire a polarized morphology and extend long cellular membrane protrusions...
  31. ncbi Functional proteomic analysis of a three-tier PKCepsilon-Akt-eNOS signaling module in cardiac protection
    Jun Zhang
    Division of Cardiology, Departments of Physiology and Medicine, University of California at Los Angeles, Los Angeles, California, USA
    Am J Physiol Heart Circ Physiol 288:H954-61. 2005
    Cardiac protective signaling networks have been shown to involve PKCepsilon. However, the molecular mechanisms by which PKCepsilon interacts with other members of these networks to form task-specific modules remain unknown...
  32. ncbi Pharmacological inhibition of epsilon PKC suppresses chronic inflammation in murine cardiac transplantation model
    Tomoyoshi Koyanagi
    Department of Chemical and Systems Biology, Stanford University School of Medicine CCSR, Rm 3145A, 269 Campus Drive Stanford, CA 94305 5174, USA
    J Mol Cell Cardiol 43:517-22. 2007
    ....
  33. pmc PKCepsilon overexpression, irrespective of genetic background, sensitizes skin to UVR-induced development of squamous-cell carcinomas
    Jordan M Sand
    Department of Human Oncology, School of Medicine and Public Health, University of Wisconsin Madison, Madison, Wisconsin, USA
    J Invest Dermatol 130:270-7. 2010
    ..We have previously shown that protein Kinase C epsilon (PKCepsilon) transgenic mice on FVB/N background, which overexpress PKCepsilon protein approximately eightfold over ..
  34. pmc HASF is a stem cell paracrine factor that activates PKC epsilon mediated cytoprotection
    Jing Huang
    Duke Cardiovascular Research Center, Duke University Medical Center, NC 27710, USA Mandel Center for Hypertension and Atherosclerosis Research, Duke University Medical Center, NC 27710, USA
    J Mol Cell Cardiol 66:157-64. 2014
    ..Furthermore, the beneficial effects of HASF were lost in mice lacking PKCε. Collectively these results identify HASF as a protein of significant therapeutic potential, acting in part through PKCε. ..
  35. pmc Interleukin-1β reduces L-type Ca2+ current through protein kinase Cϵ activation in mouse heart
    Nabil El Khoury
    From the Research Center, Montreal Heart Institute, 5000 Belanger, Montreal, Quebec H1T 1C8, The Department of Physiology, Faculty of Medicine, Universite de Montreal, Montreal, Quebec, Canada
    J Biol Chem 289:21896-908. 2014
    ..These effects implicated ROS signaling and PKCϵ activation. These findings could contribute to explain the role of IL-1β in the development of arrhythmia and heart failure...
  36. ncbi The inhibition of differentiation caused by TGFbeta in fetal myoblasts is dependent upon selective expression of PKCtheta: a possible molecular basis for myoblast diversification during limb histogenesis
    F Zappelli
    Institute of Histology and General Embryology, University of Rome La Sapienza, Italy
    Dev Biol 180:156-64. 1996
    ..They also suggest a specific role for protein kinase C theta in determining the fate of different myoblasts during muscle histogenesis...
  37. ncbi Transgenic mice overexpressing protein kinase C epsilon in their epidermis exhibit reduced papilloma burden but enhanced carcinoma formation after tumor promotion
    P J Reddig
    Department of Human Oncology, Medical School, University of Wisconsin, Madison 53792, USA
    Cancer Res 60:595-602. 2000
    To determine the role that protein kinase C epsilon (PKCepsilon) may play in skin growth, differentiation, and tumor promotion, transgenic mice were generated that overexpressed an epitope-tagged protein kinase C epsilon (T7-PKCepsilon) ..
  38. ncbi The anchoring protein RACK1 links protein kinase Cepsilon to integrin beta chains. Requirements for adhesion and motility
    Arnaud Besson
    Department of Oncology, University of Calgary, Calgary, Alberta T2N 4N1, Canada
    J Biol Chem 277:22073-84. 2002
    ..Here, we report that PKCepsilon positively regulates integrin-dependent adhesion, spreading, and motility of human glioma cells...
  39. ncbi Expression of activated PKC epsilon (PKC epsilon) protects the ischemic heart, without attenuating ischemic H(+) production
    Heather R Cross
    Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
    J Mol Cell Cardiol 34:361-7. 2002
    ..Protection occurred in the PKC epsilon hearts without attenuation of ischemic H(+) production, implying that, at least in this ischemic model, reduced acidification during ischemia is not necessary for cardioprotection...
  40. pmc Decreased anxiety-like behavior, reduced stress hormones, and neurosteroid supersensitivity in mice lacking protein kinase Cepsilon
    Clyde W Hodge
    Ernest Gallo Clinic and Research Center, Department of Neurology, University of California San Francisco, Emeryville, California 94608, USA
    J Clin Invest 110:1003-10. 2002
    Mice lacking protein kinase Cepsilon (PKCepsilon) are supersensitive to positive allosteric modulators of gamma aminobutyrate type A (GABA(A)) receptors...
  41. ncbi Ethanol differentially enhances hippocampal GABA A receptor-mediated responses in protein kinase C gamma (PKC gamma) and PKC epsilon null mice
    W R Proctor
    Department of Veterans Affairs Medical Center, Research Service, Denver, Colorado, USA
    J Pharmacol Exp Ther 305:264-70. 2003
    ..receptor-mediated inhibitory postsynaptic currents (IPSCs) in mice lacking either PKCgamma (PKCgamma(-/-)) or PKCepsilon (PKCepsilon(-/-)) isozymes and compared the results to those from corresponding wild-type littermates (PKCgamma(+..
  42. ncbi Inhibition of PKC phosphorylation of cTnI improves cardiac performance in vivo
    Brian B Roman
    Section of Cardiology, University of Illinois, 840 S Wood Street M C 715, Chicago, IL 60612, USA
    Am J Physiol Heart Circ Physiol 286:H2089-95. 2004
    ....
  43. ncbi Divergent contractile and structural responses of the murine PKC-epsilon null pulmonary circulation to chronic hypoxia
    C M Littler
    Cardiovascular Pulmonary Research Laboratory, B 133, University of Colorado Health Sciences Center, 4200 E 9th Avenue, Denver, CO 80262, USA
    Am J Physiol Lung Cell Mol Physiol 289:L1083-93. 2005
    ..Blunting of Hx-induced eNOS and iNOS expression may contribute to the increased vascular tone. PKC-epsilon appears to be an important signaling intermediate in the hypoxic regulation of each NOS isoform...
  44. ncbi Suppression of protein kinase Cepsilon mediates 17beta-estradiol-induced neuroprotection in an immortalized hippocampal cell line
    Marianna E Jung
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA
    J Neurochem 95:745-55. 2005
    ..Among the isozymes tested, betaE2 altered only PKCepsilon; it reduced the activity and membrane translocation of PKCepsilon in a manner that correlated with its ..
  45. pmc PKCepsilon plays a causal role in acute ethanol-induced steatosis
    J Phillip Kaiser
    Department of Pharmacology and Toxicology, University of Louisville Health Sciences Center, Louisville, KY 40292, USA
    Arch Biochem Biophys 482:104-11. 2009
    ..b>PKCepsilon has been shown to contribute to hepatic steatosis in experimental non-alcoholic fatty liver disease (NAFLD); ..
  46. doi Sigma-1 receptor-induced increase in murine spinal NR1 phosphorylation is mediated by the PKCalpha and epsilon, but not the PKCzeta, isoforms
    Dae Hyun Roh
    Biotherapy Human Resources Center, College of Veterinary Medicine, Chonnam National University, Gwangju, Republic of Korea
    Neurosci Lett 477:95-9. 2010
    ..PRE-induced increase in the number of spinal pNR1-ir neurons was only blocked by inhibitors of the PKCalpha and PKCepsilon isoforms, but not the PKCzeta isoform...
  47. pmc GABAA receptor trafficking is regulated by protein kinase C(epsilon) and the N-ethylmaleimide-sensitive factor
    Wen Hai Chou
    Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, Emeryville, California 94688, USA
    J Neurosci 30:13955-65. 2010
    ..Reducing NSF activity by inhibiting PKCε could help restore synaptic inhibition in disease states in which it is impaired...
  48. pmc Protein kinase Cδ mediates the activation of protein kinase D2 in platelets
    Dheeraj Bhavanasi
    Department of Physiology, Temple University School of Medicine, Philadelphia, PA, USA
    Biochem Pharmacol 82:720-7. 2011
    ..Hence, we conclude that PKD2 is a common signaling target downstream of various agonist receptors in platelets and G(q)-mediated signals along with calcium and novel PKC isoforms, in particular, PKCδ activate PKD2 in platelets...
  49. doi Insight into hypoxic preconditioning and ischemic injury through determination of nPKCε-interacting proteins in mouse brain
    Sujuan Feng
    Department of Neurobiology and Beijing Institute for Brain Disorders, Capital Medical University, Beijing 100069, PR China
    Neurochem Int 63:69-79. 2013
    ....
  50. pmc Protein kinase C isoforms α, δ and ε are differentially expressed in mouse ovaries at different stages of postnatal development
    Filiz Tepekoy
    J Ovarian Res 7:117. 2014
    ....
  51. pmc Morphine Promotes Astrocyte-Preferential Differentiation of Mouse Hippocampal Progenitor Cells via PKCε-Dependent ERK Activation and TRBP Phosphorylation
    Chi Xu
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota, USA
    Stem Cells 33:2762-72. 2015
    ..Thus, morphine modulates the lineage-specific differentiation of NPCs by PKCε-dependent ERK activation with subsequent TRBP phosphorylation and miR-181a maturation...
  52. pmc PKCε phosphorylates α4β2 nicotinic ACh receptors and promotes recovery from desensitization
    A M Lee
    Department of Pharmacology, University of Minnesota, Minneapolis, MN, USA
    Br J Pharmacol 172:4430-41. 2015
    ..We investigated whether PKCε phosphorylation of α4β2 nAChRs regulates receptor recovery from desensitization...
  53. pmc Phosphorylation of GAP-43 (growth-associated protein of 43 kDa) by conventional, novel and atypical isotypes of the protein kinase C gene family: differences between oligopeptide and polypeptide phosphorylation
    S A Oehrlein
    Institute of Physiological Chemistry, Johannes Gutenberg University, Mainz, Germany
    Biochem J 317:219-24. 1996
    ..These results suggest that there are multiple sites of interaction between GAP-43 and PKC...
  54. pmc Protein kinase C (PKC)ζ-mediated Gαq stimulation of ERK5 protein pathway in cardiomyocytes and cardiac fibroblasts
    Carlota García-Hoz
    Departamento de Biologia Molecular and Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas Universidad Autónoma de Madrid CSIC UAM, 28049 Madrid, Universidad Autonoma de Madrid, Spain
    J Biol Chem 287:7792-802. 2012
    ..Taken together, our results show that PKCζ is essential for Gq-dependent ERK5 activation in cardiomyocytes and cardiac fibroblasts and indicate a key cardiac physiological role for the Gα(q)/PKCζ/ERK5 signaling axis...
  55. pmc Non-small cell lung carcinoma cell motility, rac activation and metastatic dissemination are mediated by protein kinase C epsilon
    M Cecilia Caino
    Department of Pharmacology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 7:e31714. 2012
    ..The role of PKCε in lung cancer metastasis has not yet been established...
  56. pmc Phosphorylation of h1 calponin by PKC epsilon may contribute to facilitate the contraction of uterine myometrium in mice during pregnancy and labor
    Lesai Li
    Department of Obstetrics and Gynecology, Third Xiangya Hospital, Central South University, Changsha 410013, China
    Reprod Biol Endocrinol 10:37. 2012
    ..Here, we explore whether PKC-epsilon/h1 calponin pathway contribute to regulation of myometrial contractility and development of parturition...
  57. doi Deletion of protein kinase Cε in mice has limited effects on liver metabolite levels but alters fasting ketogenesis and gluconeogenesis
    K Raddatz
    Diabetes and Obesity Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, Australia
    Diabetologia 55:2789-93. 2012
    ..We investigated whether PKCε plays a role in other metabolic processes, to further examine its suitability as a therapeutic target...
  58. ncbi A phorbol ester receptor/protein kinase, nPKC eta, a new member of the protein kinase C family predominantly expressed in lung and skin
    S Osada
    Department of Molecular Biology, Tokyo Metropolitan Institute of Medical Science, Japan
    J Biol Chem 265:22434-40. 1990
    ..nPKC eta shows the highest sequence similarity to nPKC epsilon (59.4% identity)...
  59. ncbi Overexpressed protein kinase C-delta and -epsilon subtypes in NIH 3T3 cells exhibit differential subcellular localization and differential regulation of sodium-dependent phosphate uptake
    C Lehel
    Laboratory of Cellular Oncology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892
    J Biol Chem 269:4761-6. 1994
    ..These results suggest that each of the three PKC isotypes contribute to the regulation of sodium-dependent phosphate uptake, but through distinct mechanisms...
  60. ncbi Expression and activity of protein kinase C isoenzymes during normal and abnormal murine palate development
    G Balasubramanian
    Department of Veterinary Biomedical Sciences, University of Missouri Columbia, 65211, USA
    J Craniofac Genet Dev Biol 20:26-34. 2000
    ....
  61. ncbi Ethanol consumption and behavioral impulsivity are increased in protein kinase Cgamma null mutant mice
    B J Bowers
    Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado 80309, USA
    J Neurosci 21:RC180. 2001
    ..Therefore, PKCgamma may be an important mechanism within the cell that mediates one or more neurochemical pathways relevant to an increased predisposition to alcoholism...
  62. ncbi Molecular conformation dictates signaling module formation: example of PKCepsilon and Src tyrosine kinase
    Changxu Song
    Department of Physiology and Biophysics, University of Louisville, Louisville, Kentucky 40202, USA
    Am J Physiol Heart Circ Physiol 282:H1166-71. 2002
    ..components of protein kinase C (PKC)epsilon cardioprotective signaling complexes and found that activation of PKCepsilon induces dynamic modulation of these complexes...
  63. pmc Formation of protein kinase C(epsilon)-Lck signaling modules confers cardioprotection
    Peipei Ping
    Department of Physiology and Biophysics, University of Louisville, Louisville, Kentucky, USA
    J Clin Invest 109:499-507. 2002
    The epsilon isoform of protein kinase C (PKCepsilon) is a member of the PKC family of serine/threonine kinases and plays a critical role in protection against ischemic injury in multiple organs...
  64. ncbi Protein kinase C-alpha and protein kinase C-epsilon are required for Grb2-associated binder-1 tyrosine phosphorylation in response to platelet-derived growth factor
    Yuji Saito
    Center for Cardiovascular Research, University of Rochester, Rochester, New York 14642, USA
    J Biol Chem 277:23216-22. 2002
    ..Studies using antisense protein kinase C (PKC) oligonucleotides and specific inhibitors showed that PKCalpha and PKCepsilon are required for Gab1 tyrosine phosphorylation...
  65. ncbi Targeted disruption of the protein kinase C epsilon gene abolishes the infarct size reduction that follows ischaemic preconditioning of isolated buffer-perfused mouse hearts
    Adrian T Saurin
    Department of Cardiology, KCL, The Rayne Institute, St Thomas Hospital, London SE1 7EH, UK
    Cardiovasc Res 55:672-80. 2002
    ..We investigated whether preconditioning still occurs in a mouse line lacking cardiac PKC-epsilon protein due to a targeted disruption within the pkc-epsilon allele...
  66. ncbi Conditional rescue of protein kinase C epsilon regulates ethanol preference and hypnotic sensitivity in adult mice
    Doo Sup Choi
    Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, Emeryville, California 94608, USA
    J Neurosci 22:9905-11. 2002
    ..Mice lacking protein kinase C epsilon (PKCepsilon) consume less alcohol and show greater acute sensitivity to alcohol than do wild-type mice...
  67. pmc A role for PKC-epsilon in Fc gammaR-mediated phagocytosis by RAW 264.7 cells
    Elaine C Larsen
    Centers for Cell Biology and Cancer Research, Albany Medical College, Albany, NY 12208, USA
    J Cell Biol 159:939-44. 2002
    ..These results demonstrate a role for PKC- epsilon in Fc gammaR-mediated phagocytosis that is independent of its effects on actin assembly...
  68. ncbi Protein kinase C-epsilon-null mice have decreased hypoxic pulmonary vasoconstriction
    Cassana M Littler
    Cardiovascular Pulmonary Research Laboratory, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Am J Physiol Heart Circ Physiol 284:H1321-31. 2003
    ..Instead, the absence of PKC-epsilon allows increased expression of K(V) channels (like Kv3.1b) to occur in PASMC, which likely contributes to decreased HPV...
  69. ncbi Inhibition of the development of metastatic squamous cell carcinoma in protein kinase C epsilon transgenic mice by alpha-difluoromethylornithine accompanied by marked hair follicle degeneration and hair loss
    Deric L Wheeler
    Department of Human Oncology, Medical School, University of Wisconsin, Madison, Wisconsin 53762, USA
    Cancer Res 63:3037-42. 2003
    ..Severe hair loss observed in PKC epsilon transgenic mice on DFMO during skin tumor promotion has not been reported before in the prevention of cancer in other animal models or in human cancer prevention trials...
  70. ncbi Protein kinase Cepsilon is linked to 12-O-tetradecanoylphorbol-13-acetate-induced tumor necrosis factor-alpha ectodomain shedding and the development of metastatic squamous cell carcinoma in protein kinase Cepsilon transgenic mice
    Deric L Wheeler
    Department of Human Oncology, Medical School, University of Wisconsin, Madison, WI 53792, USA
    Cancer Res 63:6547-55. 2003
    Protein kinase Cepsilon (PKCepsilon), a Ca(2+)-independent, phospholipid-dependent serine/threonine kinase, is among the PKC isoforms expressed in mouse epidermis...
  71. ncbi Specific isoforms of protein kinase C are essential for prevention of folate-resistant neural tube defects by inositol
    Patricia Cogram
    Neural Development Unit, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Hum Mol Genet 13:7-14. 2004
    ..Hindgut cell proliferation was stimulated specifically by inositol, an effect that required activation of PKCbetaI. Our findings reveal an essential role of specific PKC isoforms in mediating the prevention of mouse NTDs by inositol...
  72. ncbi Sublethal simulated ischemia promotes delayed resistance against ischemia via ATP-sensitive (K+) channels in murine myocytes: role of PKC and iNOS
    Mohammed A Nayeem
    DIR ETP LPC MEM, National Institute of Environment and Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Antioxid Redox Signal 6:375-83. 2004
    ..88 +/- 1.31), and 5-HD (47.20 +/- 1.56). Simultaneously, SSI-induced up-regulation of A(1) adenosine receptor, PKC-epsilon, iNOS, and opening of both membrane and mitochondrial K(ATP) channels also was observed compared with controls...
  73. ncbi Activation of protein kinase C epsilon inhibits the two-pore domain K+ channel, TASK-1, inducing repolarization abnormalities in cardiac ventricular myocytes
    Alessandra Besana
    Center for Molecular Therapeutics, Department of Pharmacology, Columbia University, New York, New York 10032, USA
    J Biol Chem 279:33154-60. 2004
    ..PKC inhibitor or activator peptides in patch clamp experiments, we now demonstrate that activation of PKCepsilon is both necessary and sufficient to regulate murine TASK-1 current in a heterologous expression system and to ..
  74. ncbi Protein kinase C activity regulates the onset of anaphase I in mouse oocytes
    Maria M Viveiros
    Center for Animal Transgenesis and Germ Cell Research, Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, Pennsylvania 19348, USA
    Biol Reprod 71:1525-32. 2004
    ..Similarly, failure to regulate PKC activity at the preovulatory stage likely promotes arrest at MI...
  75. ncbi Specific modulation of Na+ channels in hippocampal neurons by protein kinase C epsilon
    Yuan Chen
    Department of Pharmacology, University of Washington, Seattle, Washington 98195 7280, USA
    J Neurosci 25:507-13. 2005
    ..Inclusion of a selective PKCepsilon-anchoring inhibitor peptide (PKCepsilon-I) in the recording pipette prevented the reduction of peak Na+ current ..
  76. ncbi Regulation of highly cytokinergic IgE-induced mast cell adhesion by Src, Syk, Tec, and protein kinase C family kinases
    Jiro Kitaura
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Immunol 174:4495-504. 2005
    ..Thus, binding of HC IgEs to Fc epsilon RI induces adhesion of mast cells to fibronectin by modulating cellular activation signals in a unique fashion...
  77. ncbi Protein kinase C epsilon induces systolic cardiac failure marked by exhausted inotropic reserve and intact Frank-Starling mechanism
    David E Montgomery
    Department of Medicine, Section of Cardiology, Univ of Illinois at Chicago, College of Medicine, Chicago, IL 60612, USA
    Am J Physiol Heart Circ Physiol 289:H1881-8. 2005
    ....
  78. ncbi The very C-terminus of protein kinase Cepsilon is critical for the full catalytic competence but its hydrophobic motif is dispensable for the interaction with 3-phosphoinositide-dependent kinase-1
    Yimin Zhu
    Department of Biochemistry, Faculty of Medicine, National University of Singapore, 8 Medical Drive, 117597, Singapore
    Cell Signal 18:807-18. 2006
    In this article, we explore the role of the C-terminus (V5 domain) of PKCepsilon plays in the catalytic competence of the kinase using serial truncations followed by immune-complex kinase assays...
  79. ncbi Expression profile of protein kinase C isozymes in preimplantation mouse development
    Hesam Dehghani
    Department of Biomedical Sciences, University of Guelph, Guelph, Ontario, N1G 2W1 Canada
    Reproduction 130:441-51. 2005
    ....
  80. ncbi Stimulation of oncogenic metabotropic glutamate receptor 1 in melanoma cells activates ERK1/2 via PKCepsilon
    YARI E MARIN
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers University, 164 Frelinghuysen Rd, Piscataway, NJ 08854, USA
    Cell Signal 18:1279-86. 2006
    ..We also show that ERK1/2 activation by Grm1 was PKC-dependent, but cAMP and PKA-independent. PKCepsilon was shown to play a pivotal role in Grm1-mediated ERK1/2 phosphorylation...
  81. ncbi Cdc42 is involved in PKCepsilon- and delta-induced neurite outgrowth and stress fibre dismantling
    Ulrika Trollér
    Lund University, Department of Laboratory Medicine, Molecular Medicine, Entrance 78, 3rd Floor, Malmo University Hospital, SE 205 02 Malmo, Sweden
    Biochem Biophys Res Commun 349:91-8. 2006
    ..We conclude that Cdc42 is an important downstream factor in the pathway through which PKC mediates morphological and cytoskeletal effects...
  82. ncbi Fucoidan prevents C epsilon germline transcription and NFkappaB p52 translocation for IgE production in B cells
    Souichi Oomizu
    Hiroshima Prefectural Institute of Industrial Science and Technology, Higashi Hiroshima, Japan
    Biochem Biophys Res Commun 350:501-7. 2006
    ..These results suggest that fucoidan inhibited IgE production by preventing the NFkappaB p52-mediated pathways activated by CD40...
  83. pmc Mitochondrial ROS-PKCepsilon signaling axis is uniquely involved in hypoxic increase in [Ca2+]i in pulmonary artery smooth muscle cells
    Rakesh Rathore
    Center for Cardiovascular Sciences, Albany Medical College, Albany, NY 12208, USA
    Biochem Biophys Res Commun 351:784-90. 2006
    ..Here we for the first time report that acute hypoxia significantly increased total PKC and PKCepsilon activity in pulmonary, but not mesenteric arteries, while these two tissues showed comparable PKCepsilon protein ..
  84. ncbi Fatty acid represses insulin receptor gene expression by impairing HMGA1 through protein kinase Cepsilon
    Debleena Dey
    Molecular Endocrinology Laboratory, Indian Institute of Chemical Biology, 4, Raja S C Mullick Road, Kolkata 700032, India
    Biochem Biophys Res Commun 357:474-9. 2007
    ..Consequently, PDK1 phosphorylation of plasma membrane bound PKCepsilon was also inhibited...
  85. pmc Protein kinase Cepsilon (PKCepsilon) and Src control PKCdelta activation loop phosphorylation in cardiomyocytes
    Vitalyi O Rybin
    Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Biol Chem 282:23631-8. 2007
    ..We used a PKCepsilon overexpression strategy as an initial approach to discriminate two possible novel PKC mechanisms, namely ..
  86. ncbi Phosphorylation at Ser729 specifies a Golgi localisation for protein kinase C epsilon (PKCepsilon) in 3T3 fibroblasts
    Tian Rui Xu
    SHWFGF Proteomics Section, Joseph Black Building, University of Glasgow, University Avenue, Glasgow, G12 8QQ, UK
    Cell Signal 19:1986-95. 2007
    We demonstrate that GFP-PKCepsilon concentrates at a perinuclear site in living fibroblasts and that cell passage induces rapid translocation of PKCepsilon to the periphery where it appears to colocalise with F-actin...
  87. ncbi nPKCepsilon, a P2Y2-R downstream effector in regulated mucin secretion from airway goblet cells
    Camille Ehre
    CCystic Fibrosis Pulmonary Research and Treatment Center, University of North Carolina, Chapel Hill, North Carolina 27599 7248, USA
    Am J Physiol Cell Physiol 293:C1445-54. 2007
    ..The translocation of nPKCdelta observed in activated cells is likely not related to mucin secretion but to some other aspect of goblet cell biology...
  88. doi Role of protein kinase C in selective inhibition of mouse retinal neurites during contacts with chondroitin sulfates
    Joyce Shi Ying Lam
    Department of Anatomy, The Chinese University of Hong Kong, Shatin, N T, Hong Kong, China
    Neurosci Lett 434:150-4. 2008
    ....
  89. doi Acrolein consumption exacerbates myocardial ischemic injury and blocks nitric oxide-induced PKCepsilon signaling and cardioprotection
    Guang Wu Wang
    Department of Physiology and the Cardiovascular Research Laboratories, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    J Mol Cell Cardiol 44:1016-22. 2008
    ..To examine potential intracellular targets of aldehydes, we investigated the impact of acrolein on mitochondrial PKCepsilon signaling in the heart...
  90. pmc Protein kinase C epsilon mediation of CRF- and ethanol-induced GABA release in central amygdala
    Michal Bajo
    Molecular and Integrative Neurosciences Department, Committee on Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 105:8410-5. 2008
    ..Because mutant mice that lack PKCepsilon exhibit reduced anxiety-like behavior and alcohol consumption, we investigated whether PKCepsilon lies ..
  91. pmc PKCepsilon stimulated arginine methylation of RIP140 for its nuclear-cytoplasmic export in adipocyte differentiation
    Pawan Gupta
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota, United States of America
    PLoS ONE 3:e2658. 2008
    ..Previously we identified three methylated arginine residues in RIP140, which rendered its export to the cytoplasm; but it was unclear what triggered RIP140 arginine methylation...
  92. doi Role of protein kinase C and phosphoinositide 3-kinase-Akt in substance P-induced proinflammatory pathways in mouse macrophages
    Jia Sun
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    FASEB J 23:997-1010. 2009
    ..Collectively, our results suggest that SP/NK-1R activates two convergent proinflammatory signaling pathways, PKCs and PI3K-Akt, resulting in ERK1/2 and NF-kappaB activation and chemokine production in mouse macrophages...
  93. pmc Protein kinase Cepsilon inhibits UVR-induced expression of FADD, an adaptor protein, linked to both Fas- and TNFR1-mediated apoptosis
    Moammir Hasan Aziz
    Department of Human Oncology, Medical School, University of Wisconsin, Madison, Wisconsin 53792, USA
    J Invest Dermatol 129:2011-21. 2009
    ..Here, we elucidated the mechanisms associated with the inhibition of UVR-induced appearance of sunburn cells in PKCepsilon transgenic mice...
  94. pmc Deletion of PKCepsilon selectively enhances the amplifying pathways of glucose-stimulated insulin secretion via increased lipolysis in mouse beta-cells
    James Cantley
    Diabetes and Obesity Research Program, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia
    Diabetes 58:1826-34. 2009
    ..Functional ablation of protein kinase C epsilon (PKCepsilon) has been shown to improve glucose homeostasis in models of type 2 diabetes and, in particular, to enhance ..
  95. doi PKC epsilon has an alcohol-binding site in its second cysteine-rich regulatory domain
    Joydip Das
    Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX 77204, USA
    Biochem J 421:405-13. 2009
    ..The present results provide direct evidence for the presence of an allosteric alcohol-binding site on protein kinase C epsilon and underscore the role of His236 and Tyr238 residues in alcohol binding...
  96. doi A role for PKCepsilon during C2C12 myogenic differentiation
    Gian Carlo Gaboardi
    Cellular Signalling Laboratory, Department of Human Anatomical Sciences, University of Bologna, 40126 Bologna, Italy
    Cell Signal 22:629-35. 2010
    ..We show that during myotube formation, there is a marked increase of PKCepsilon and eta expression, and that PKCepsilon is able to form a complex with PLCgamma1...
  97. pmc Interleukin-1 Receptor-Associated Kinase-1 (IRAK-1) functionally associates with PKCepsilon and VASP in the regulation of macrophage migration
    Lu Gan
    Department of Biology, Virginia Tech, Blacksburg, VA 24061, USA
    Mol Immunol 47:1278-82. 2010
    ..Mechanistically, we demonstrated that IRAK-1 works downstream of PKCepsilon and upstream of VASP, a member of Ena/VASP family proteins...
  98. doi PKCε regulates contraction-stimulated GLUT4 traffic in skeletal muscle cells
    Wenyan Niu
    Department of Immunology, Tianjin Key Laboratory of Cellular and Molecular Immunology, Key Laboratory of Immuno Microenvironment and Disease of the Educational Ministry of China, Tianjin Medical University, Tianjin, China
    J Cell Physiol 226:173-80. 2011
    ..These findings support a role for novel PKC isoforms, especially PKCε, in contraction-stimulated GLUT4 traffic in muscle cells...
  99. doi High-molecular weight hyaluronan reduced renal PKC activation in genetically diabetic mice
    Giuseppe M Campo
    Department of Biochemical, Physiological and Nutritional Sciences, section of Medical Chemistry, School of Medicine, University of Messina, Policlinico Universitario, Messina, Italy
    Biochim Biophys Acta 1802:1118-30. 2010
    ..These results suggest that the CD44 and PKC play an important role in diabetes and interaction of high-molecular weight HA with these proteins may reduce inflammation and secondary pathologies due to this disease...
  100. pmc Differential expression of protein kinase C isoforms in coronary arteries of diabetic mice lacking the G-protein Gα11
    Dieter Paul Hoyer
    Department of Internal Medicine III, University of Cologne, Kerpener Str, 62, 50937 Cologne, Germany
    Cardiovasc Diabetol 9:93. 2010
    ..The present study was therefore designed to determine the role of Gq-protein signalling via Gα11 in diabetes for the expression of PKC isozymes in the coronary vessels...
  101. pmc Transgenic overexpression of PKCε in the mouse prostate induces preneoplastic lesions
    Fernando Benavides
    Department of Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Smithville, TX, USA
    Cell Cycle 10:268-77. 2011
    ..PKCε, the product of the PRKCE gene, is up-regulated in various types of cancers including prostate, lung and breast cancer...

Research Grants4

  1. Alcohol modulates TLR2 signaling in airway epithelium
    KRISTINA BAILEY; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  2. Alcohol Modulation of Cerebellar Synaptic Currents
    William Proctor; Fiscal Year: 2006
    ..The combination of our proposed and ongoing genetic studies may aid the identification of more sensitive drug targets and the development of novel drugs for rational therapeutic approaches to alcoholism. ..
  3. High Gulcose Promotes Myocyte Apoptosis by PKC Pathways
    Ashwani Malhotra; Fiscal Year: 2008
    ..The proposed investigations are novel and fundamental to the development of gene based therapy to inhibit myocyte apoptosis in the diabetic heart. ..
  4. Identification of Alcohol Binding Site(s) in Protein Kinase C Epsilon
    Joydip Das; Fiscal Year: 2007
    ..of this proposal is to identify alcohol binding sites on a signal transducing protein, protein kinase C epsilon (PKCe), and to determine the secondary structure of these sites...