Gene Symbol: Prkcd
Description: protein kinase C, delta
Alias: AI385711, D14Ertd420e, PKC[d], PKCdelta, Pkcd, protein kinase C delta type, nPKC-delta, protein kinase C delta variant IX, protein kinase C, delta IV, protein kinase C, delta V, protein kinase C[d], tyrosine-protein kinase PRKCD
Species: mouse
Products:     Prkcd

Top Publications

  1. Le Good J, Ziegler W, Parekh D, Alessi D, Cohen P, Parker P. Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1. Science. 1998;281:2042-5 pubmed
    ..PDK1 phosphorylated the activation loop sites of PKCzeta and PKCdelta in vitro and in a phosphoinositide 3-kinase (PI 3-kinase)-dependent manner in vivo in human embryonic kidney (293)..
  2. Mecklenbrauker I, Kalled S, Leitges M, Mackay F, Tarakhovsky A. Regulation of B-cell survival by BAFF-dependent PKCdelta-mediated nuclear signalling. Nature. 2004;431:456-61 pubmed
    ..we report a mechanism for the regulation of peripheral B-cell survival by serine/threonine protein kinase Cdelta (PKCdelta): spontaneous death of resting B cells is regulated by nuclear localization of PKCdelta that contributes to ..
  3. Trollér U, Larsson C. Cdc42 is involved in PKCepsilon- and delta-induced neurite outgrowth and stress fibre dismantling. Biochem Biophys Res Commun. 2006;349:91-8 pubmed
    ..We conclude that Cdc42 is an important downstream factor in the pathway through which PKC mediates morphological and cytoskeletal effects. ..
  4. Yamanouchi D, Kato K, Ryer E, Zhang F, Liu B. Protein kinase C delta mediates arterial injury responses through regulation of vascular smooth muscle cell apoptosis. Cardiovasc Res. 2010;85:434-43 pubmed publisher
    ..We have previously demonstrated that protein kinase C delta (PKCdelta) regulates both apoptosis and proliferation of VSMC in vitro...
  5. Bezy O, Tran T, Pihlajamaki J, Suzuki R, Emanuelli B, Winnay J, et al. PKC? regulates hepatic insulin sensitivity and hepatosteatosis in mice and humans. J Clin Invest. 2011;121:2504-17 pubmed publisher
    ..b>PRKCD gene expression was also elevated in obese humans and was positively correlated with fasting glucose and ..
  6. Humphries M, Limesand K, Schneider J, Nakayama K, Anderson S, Reyland M. Suppression of apoptosis in the protein kinase Cdelta null mouse in vivo. J Biol Chem. 2006;281:9728-37 pubmed
    ..We have used the PKCdelta(-/-) mouse to ask if loss of PKCdelta protects salivary glands against gamma-irradiation-induced apoptosis in ..
  7. Zappelli F, Willems D, Osada S, Ohno S, Wetsel W, Molinaro M, et al. The inhibition of differentiation caused by TGFbeta in fetal myoblasts is dependent upon selective expression of PKCtheta: a possible molecular basis for myoblast diversification during limb histogenesis. Dev Biol. 1996;180:156-64 pubmed
    ..They also suggest a specific role for protein kinase C theta in determining the fate of different myoblasts during muscle histogenesis. ..
  8. Pauken C, Capco D. The expression and stage-specific localization of protein kinase C isotypes during mouse preimplantation development. Dev Biol. 2000;223:411-21 pubmed
    ..Two isotypes have a stage-dependent nuclear localization. In addition, within each blastomere PKC isotypes occupy different subcellular locations in a stage-dependent fashion. ..
  9. Geraldes P, Hiraoka Yamamoto J, Matsumoto M, Clermont A, Leitges M, Marette A, et al. Activation of PKC-delta and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy. Nat Med. 2009;15:1298-306 pubmed publisher
    ..Here we show that hyperglycemia persistently activates protein kinase C-delta (PKC-delta, encoded by Prkcd) and p38alpha mitogen-activated protein kinase (MAPK) to increase the expression of a previously unknown target of ..

More Information


  1. Osada S, Mizuno K, Saido T, Suzuki K, Kuroki T, Ohno S. A new member of the protein kinase C family, nPKC theta, predominantly expressed in skeletal muscle. Mol Cell Biol. 1992;12:3930-8 pubmed
    ..a protein, nPKC theta, which consists of 707 amino acid residues and showed the highest sequence similarity to nPKC delta (67.0% in total)...
  2. Zhang D, Kanthasamy A, Yang Y, Anantharam V, Kanthasamy A. Protein kinase C delta negatively regulates tyrosine hydroxylase activity and dopamine synthesis by enhancing protein phosphatase-2A activity in dopaminergic neurons. J Neurosci. 2007;27:5349-62 pubmed
    ..present study, we report a novel interaction between a key member of the novel PKC family, protein kinase Cdelta (PKCdelta), and TH, in which the kinase modulates dopamine synthesis by negatively regulating TH activity via protein ..
  3. Liu J, Yang D, Minemoto Y, Leitges M, Rosner M, Lin A. NF-kappaB is required for UV-induced JNK activation via induction of PKCdelta. Mol Cell. 2006;21:467-80 pubmed
    ..In resting cells, the preexisting nuclear RelA has already been recruited to PKCdelta promoter and is essential for its expression...
  4. Uchida T, Iwashita N, Ohara Imaizumi M, Ogihara T, Nagai S, Choi J, et al. Protein kinase Cdelta plays a non-redundant role in insulin secretion in pancreatic beta cells. J Biol Chem. 2007;282:2707-16 pubmed
    ..In this study we investigated the role of PKCdelta, a major isoform expressed in pancreatic beta cells on beta cell function...
  5. Qu Y, Misaghi S, Izrael Tomasevic A, Newton K, Gilmour L, Lamkanfi M, et al. Phosphorylation of NLRC4 is critical for inflammasome activation. Nature. 2012;490:539-42 pubmed publisher
    ..Biochemical purification of the NLRC4-phosphorylating activity and a screen of kinase inhibitors identified PRKCD (PKC?) as a candidate NLRC4 kinase...
  6. Brodie C, Blumberg P. Regulation of cell apoptosis by protein kinase c delta. Apoptosis. 2003;8:19-27 pubmed
    ..b>PKCdelta a member of the novel PKC subfamily, is actively involved in cell apoptosis in a stimulus and tissue specific ..
  7. Miyamoto A, Nakayama K, Imaki H, Hirose S, Jiang Y, Abe M, et al. Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cdelta. Nature. 2002;416:865-9 pubmed
    ..These results suggest that PKC-delta has an indispensable function in negative regulation of B-cell proliferation, and is particularly important for the establishment of B-cell tolerance. ..
  8. Lee Y, Soh J, Dean N, Cho C, Kim T, Lee S, et al. Protein kinase Cdelta overexpression enhances radiation sensitivity via extracellular regulated protein kinase 1/2 activation, abolishing the radiation-induced G(2)-M arrest. Cell Growth Differ. 2002;13:237-46 pubmed
    ..However,the role of PKCdelta in radiosensitivity and cell cycle regulation remains unclear...
  9. Leitges M, Gimborn K, Elis W, Kalesnikoff J, Hughes M, Krystal G, et al. Protein kinase C-delta is a negative regulator of antigen-induced mast cell degranulation. Mol Cell Biol. 2002;22:3970-80 pubmed
    ..Altogether, our data suggest that PKC-delta is a negative regulator of antigen-induced mast cell degranulation. ..
  10. Ryer E, Sakakibara K, Wang C, Sarkar D, Fisher P, Faries P, et al. Protein kinase C delta induces apoptosis of vascular smooth muscle cells through induction of the tumor suppressor p53 by both p38-dependent and p38-independent mechanisms. J Biol Chem. 2005;280:35310-7 pubmed
    ..In the present study, we examined the novel PKC isoform protein kinase C delta (PKCdelta) and its role in vascular SMC apoptosis...
  11. Tu X, Joeng K, Nakayama K, Nakayama K, Rajagopal J, Carroll T, et al. Noncanonical Wnt signaling through G protein-linked PKCdelta activation promotes bone formation. Dev Cell. 2007;12:113-27 pubmed
    ..Wnt3a signals through the Galpha(q/11) subunits of G proteins to activate phosphatidylinositol signaling and PKCdelta in the murine ST2 cells...
  12. Pabla N, Dong G, Jiang M, Huang S, Kumar M, Messing R, et al. Inhibition of PKC? reduces cisplatin-induced nephrotoxicity without blocking chemotherapeutic efficacy in mouse models of cancer. J Clin Invest. 2011;121:2709-22 pubmed publisher
    ..Together these results demonstrate a role of PKC? in cisplatin nephrotoxicity and support targeting PKC? as an effective strategy for renoprotection during cisplatin-based cancer therapy. ..
  13. Bekhite M, Finkensieper A, Binas S, Müller J, Wetzker R, Figulla H, et al. VEGF-mediated PI3K class IA and PKC signaling in cardiomyogenesis and vasculogenesis of mouse embryonic stem cells. J Cell Sci. 2011;124:1819-30 pubmed publisher
    ..Akt downstream of PI3K is involved in both cardiomyogenesis and vasculogenesis, whereas PKC is involved only in vasculogenesis. ..
  14. Zhao C, Li K, Li J, Zheng W, Liang X, Geng A, et al. PKCdelta regulates cortical radial migration by stabilizing the Cdk5 activator p35. Proc Natl Acad Sci U S A. 2009;106:21353-8 pubmed publisher
    ..Here, we show that PKCdelta, a member of novel PKC expressing in cortical neurons, could stabilize p35 by direct phosphorylation...
  15. Lizotte F, Paré M, Denhez B, Leitges M, Guay A, Geraldes P. PKC? impaired vessel formation and angiogenic factor expression in diabetic ischemic limbs. Diabetes. 2013;62:2948-57 pubmed publisher
    ..Ischemic adductor muscles of diabetic Prkcd(+/+) mice exhibited reduced blood reperfusion, vascular density, and number of small vessels compared with ..
  16. Mecklenbrauker I, Saijo K, Zheng N, Leitges M, Tarakhovsky A. Protein kinase Cdelta controls self-antigen-induced B-cell tolerance. Nature. 2002;416:860-5 pubmed
    ..As deficiency of PKC-delta does not affect BCR-mediated B-cell activation in vitro and in vivo, our data suggest a selective and essential role of PKC-delta in tolerogenic, but not immunogenic, B-cell responses. ..
  17. Iwabu A, Smith K, Allen F, Lauffenburger D, Wells A. Epidermal growth factor induces fibroblast contractility and motility via a protein kinase C delta-dependent pathway. J Biol Chem. 2004;279:14551-60 pubmed
    ..Interestingly, PKCdelta is the most strongly phosphorylated isoform, and the preferential PKCdelta inhibitor rottlerin largely prevented ..
  18. Greene M, Burrington C, Ruhoff M, Johnson A, Chongkrairatanakul T, Kangwanpornsiri A. PKC{delta} is activated in a dietary model of steatohepatitis and regulates endoplasmic reticulum stress and cell death. J Biol Chem. 2010;285:42115-29 pubmed publisher
  19. Brandt D, Goerke A, Heuer M, Gimona M, Leitges M, Kremmer E, et al. Protein kinase C delta induces Src kinase activity via activation of the protein tyrosine phosphatase PTP alpha. J Biol Chem. 2003;278:34073-8 pubmed
  20. Bai X, Margariti A, Hu Y, Sato Y, Zeng L, Ivetic A, et al. Protein kinase C{delta} deficiency accelerates neointimal lesions of mouse injured artery involving delayed reendothelialization and vasohibin-1 accumulation. Arterioscler Thromb Vasc Biol. 2010;30:2467-74 pubmed publisher
    ..To use protein kinase C (PKC) ?-knockout mice to investigate the role of PKC? in lesion development and to understand the underlying mechanism of the vascular disease...
  21. Cremasco V, Decker C, Stumpo D, Blackshear P, Nakayama K, Nakayama K, et al. Protein kinase C-delta deficiency perturbs bone homeostasis by selective uncoupling of cathepsin K secretion and ruffled border formation in osteoclasts. J Bone Miner Res. 2012;27:2452-63 pubmed publisher
  22. Jin H, Kanthasamy A, Anantharam V, Rana A, Kanthasamy A. Transcriptional regulation of pro-apoptotic protein kinase Cdelta: implications for oxidative stress-induced neuronal cell death. J Biol Chem. 2011;286:19840-59 pubmed publisher
    ..To characterize the regulation of PKC? expression, we cloned an ?2-kbp 5'-promoter segment of the mouse Prkcd gene...
  23. Frangioudakis G, Burchfield J, Narasimhan S, Cooney G, Leitges M, Biden T, et al. Diverse roles for protein kinase C delta and protein kinase C epsilon in the generation of high-fat-diet-induced glucose intolerance in mice: regulation of lipogenesis by protein kinase C delta. Diabetologia. 2009;52:2616-20 pubmed publisher
    ..Neither the high-fat diet nor Prkcd deletion affected maximal insulin signalling. The activation of PKCdelta in muscle from fat-fed mice was enhanced by Prkce deletion...
  24. Choi B, Hur E, Lee J, Jun D, Kim K. Protein kinase Cdelta-mediated proteasomal degradation of MAP kinase phosphatase-1 contributes to glutamate-induced neuronal cell death. J Cell Sci. 2006;119:1329-40 pubmed
    ..Glutamate-induced activation of ERK1/2 was blocked by inhibition of PKCdelta, confirming that ERK1/2 is regulated by PKCdelta...
  25. Chou W, Choi D, Zhang H, Mu D, McMahon T, Kharazia V, et al. Neutrophil protein kinase Cdelta as a mediator of stroke-reperfusion injury. J Clin Invest. 2004;114:49-56 pubmed
    ..Here we describe studies with mice lacking protein kinase Cdelta (PKCdelta) showing that absence of this enzyme markedly reduces reperfusion injury following transient ischemia...
  26. Lima F, Niger C, Hebert C, Stains J. Connexin43 potentiates osteoblast responsiveness to fibroblast growth factor 2 via a protein kinase C-delta/Runx2-dependent mechanism. Mol Biol Cell. 2009;20:2697-708 pubmed publisher
    ..Inhibition of protein kinase C delta (PKCdelta) with rottlerin or siRNA-mediated knockdown abrogates the osteocalcin response to FGF2...
  27. Leitges M, Mayr M, Braun U, Mayr U, Li C, Pfister G, et al. Exacerbated vein graft arteriosclerosis in protein kinase Cdelta-null mice. J Clin Invest. 2001;108:1505-12 pubmed
    ..protein kinase C (PKC) family signal cells to undergo proliferation, differentiation, or apoptosis, we generated PKCdelta knockout mice and performed vein bypass grafts on these animals...
  28. Pula G, Schuh K, Nakayama K, Nakayama K, Walter U, Poole A. PKCdelta regulates collagen-induced platelet aggregation through inhibition of VASP-mediated filopodia formation. Blood. 2006;108:4035-44 pubmed
    Protein kinase Cdelta (PKCdelta) has been shown by pharmacologic approaches to negatively regulate collagen-induced platelet aggregation. Here we addressed the molecular and cellular mechanisms underlying this negative regulation...
  29. Jackson D, Foster D. The enigmatic protein kinase Cdelta: complex roles in cell proliferation and survival. FASEB J. 2004;18:627-36 pubmed
    Protein kinase Cdelta (PKCdelta) has been implicated both as a tumor suppressor and a positive regulator of cell cycle progression. PKCdelta has also been reported to positively and negatively regulate apoptotic programs...
  30. Viveiros M, O Brien M, Wigglesworth K, Eppig J. Characterization of protein kinase C-delta in mouse oocytes throughout meiotic maturation and following egg activation. Biol Reprod. 2003;69:1494-9 pubmed
  31. Carracedo S, Braun U, Leitges M. Expression pattern of protein kinase C? during mouse embryogenesis. BMC Dev Biol. 2013;13:2 pubmed publisher
  32. Cantley J, Boslem E, Laybutt D, Cordery D, Pearson G, Carpenter L, et al. Deletion of protein kinase C? in mice modulates stability of inflammatory genes and protects against cytokine-stimulated beta cell death in vitro and in vivo. Diabetologia. 2011;54:380-9 pubmed publisher
    ..Islets isolated from wild-type or Prkcd(-/-) mice were treated with IL-1?, TNF-? and IFN? and assayed for apoptosis, nitric oxide (NO) generation and ..
  33. Bhatt K, Pandey R, Dahiya Y, Sodhi A. Protein kinase Cdelta and protein tyrosine kinase regulate peptidoglycan-induced nuclear factor-kappaB activation and inducible nitric oxide synthase expression in mouse peritoneal macrophages in vitro. Mol Immunol. 2010;47:861-70 pubmed publisher
    ..Protein tyrosine kinase inhibitor, genestein and PKCdelta inhibitor, rottlerin attenuated the PGN-induced expression of iNOS and NO...
  34. Acin Perez R, Hoyos B, Gong J, Vinogradov V, Fischman D, Leitges M, et al. Regulation of intermediary metabolism by the PKCdelta signalosome in mitochondria. FASEB J. 2010;24:5033-42 pubmed publisher
    ..Our findings define the molecular mechanisms underlying the signaling function of PKC? in mitochondria. ..
  35. Mayr M, Chung Y, Mayr U, McGregor E, Troy H, Baier G, et al. Loss of PKC-delta alters cardiac metabolism. Am J Physiol Heart Circ Physiol. 2004;287:H937-45 pubmed
    ..The consequences of these metabolic alterations on sensitivity to myocardial ischemia are further explored in the accompanyingpaper (20). ..
  36. Qi X, Mochly Rosen D. The PKCdelta -Abl complex communicates ER stress to the mitochondria - an essential step in subsequent apoptosis. J Cell Sci. 2008;121:804-13 pubmed publisher
    ..In this study, we found that, in response to ER stress in vivo and in vitro, PKCdelta translocates to the ER where it binds to the tyrosine kinase Abl...
  37. Humphries M, Ohm A, Schaack J, Adwan T, Reyland M. Tyrosine phosphorylation regulates nuclear translocation of PKCdelta. Oncogene. 2008;27:3045-53 pubmed
    b>PKCdelta is essential for apoptosis, but regulation of the proapoptotic function of this ubiquitous kinase is not well understood...
  38. DeVries T, Neville M, Reyland M. Nuclear import of PKCdelta is required for apoptosis: identification of a novel nuclear import sequence. EMBO J. 2002;21:6050-60 pubmed
    We have shown previously that protein kinase Cdelta (PKCdelta) is required for mitochondrial-dependent apoptosis...
  39. Walker J, Castagnino P, Chung B, Kazanietz M, Assoian R. Post-transcriptional destabilization of p21cip1 by protein kinase C in fibroblasts. J Biol Chem. 2006;281:38127-32 pubmed, we have shown that pharmacological inhibition of protein kinase C (PKC), expression of dominant negative PKCdelta, or knockdown of PKCdelta with small interfering RNA elevates p21(cip1) protein levels in mouse embryo ..
  40. Li B, Ishii T, Tan C, Soh J, Goff S. Pathways of induction of peroxiredoxin I expression in osteoblasts: roles of p38 mitogen-activated protein kinase and protein kinase C. J Biol Chem. 2002;277:12418-22 pubmed
    ..Furthermore, rottlerin, an inhibitor of protein kinase Cdelta (PKCdelta) and calmodulin kinase III, abrogated the up-regulation at both protein and mRNA levels...
  41. Ma W, Baumann C, Viveiros M. Lack of protein kinase C-delta (PKCδ) disrupts fertilization and embryonic development. Mol Reprod Dev. 2015;82:797-808 pubmed publisher
    ..function of protein kinase C delta (PKCδ) during fertilization and embryonic development using gene-knockout (Prkcd(-/-)) mice...
  42. Mundell S, Jones M, Hardy A, Barton J, Beaucourt S, Conley P, et al. Distinct roles for protein kinase C isoforms in regulating platelet purinergic receptor function. Mol Pharmacol. 2006;70:1132-42 pubmed
    ..Expression of PKCalpha and PKCdelta dominant-negative mutants in 1321N1 cells revealed that both isoforms regulated P2Y1 receptor signaling and ..
  43. Yoshida K, Yamaguchi T, Shinagawa H, Taira N, Nakayama K, Miki Y. Protein kinase C delta activates topoisomerase IIalpha to induce apoptotic cell death in response to DNA damage. Mol Cell Biol. 2006;26:3414-31 pubmed
    ..The results also demonstrate that the proapoptotic kinase protein kinase C delta (PKCdelta) interacts with topoisomerase IIalpha...
  44. Lee Y, Cho H, Soh J, Jhon G, Cho C, Chung H, et al. Oxidative stress-induced apoptosis is mediated by ERK1/2 phosphorylation. Exp Cell Res. 2003;291:251-66 pubmed
    ..ERK1/2 activation was not only Ras-Raf dependent, but also both tyrosine kinase (PDGFbeta receptor and Src) and PKCdelta dependent...
  45. Panicker N, Saminathan H, Jin H, Neal M, Harischandra D, Gordon R, et al. Fyn Kinase Regulates Microglial Neuroinflammatory Responses in Cell Culture and Animal Models of Parkinson's Disease. J Neurosci. 2015;35:10058-77 pubmed publisher
    ..Our finding has important clinical significance to PD because it identifies Fyn as a potential translational target for intervention of progressive neurodegenerative processes in PD. ..
  46. Okuyama R, Nguyen B, Talora C, Ogawa E, Tommasi di Vignano A, Lioumi M, et al. High commitment of embryonic keratinocytes to terminal differentiation through a Notch1-caspase 3 regulatory mechanism. Dev Cell. 2004;6:551-62 pubmed
    ..Thus, a Notch1-caspase 3 regulatory mechanism underlies the intrinsically high commitment of embryonic keratinocytes to terminal differentiation. ..
  47. Ma J, Haydar T, Radoja S. Protein kinase C delta localizes to secretory lysosomes in CD8+ CTL and directly mediates TCR signals leading to granule exocytosis-mediated cytotoxicity. J Immunol. 2008;181:4716-22 pubmed
  48. Chen J, Lin H, Kim K, Lin A, Forman H, Ann D. Novel roles for protein kinase Cdelta-dependent signaling pathways in acute hypoxic stress-induced autophagy. J Biol Chem. 2008;283:34432-44 pubmed publisher
    ..puncta accumulation, hallmarks of autophagic processing, and that this process involves protein kinase Cdelta (PKCdelta), and occurs prior to the induction of BNIP3 (Bcl-2/adenovirus E1B 19-kDa interacting protein 3)...
  49. Ramnath R, Sun J, Adhikari S, Zhi L, Bhatia M. Role of PKC-delta on substance P-induced chemokine synthesis in pancreatic acinar cells. Am J Physiol Cell Physiol. 2008;294:C683-92 pubmed
    ..These results show that PKC-delta is an important proinflammatory signal transducer for SP-NK1R-induced chemokine production in pancreatic acinar cells...
  50. Ehre C, Zhu Y, Abdullah L, Olsen J, Nakayama K, Nakayama K, et al. nPKCepsilon, a P2Y2-R downstream effector in regulated mucin secretion from airway goblet cells. Am J Physiol Cell Physiol. 2007;293:C1445-54 pubmed
    ..The translocation of nPKCdelta observed in activated cells is likely not related to mucin secretion but to some other aspect of goblet cell biology...
  51. Oehrlein S, Parker P, Herget T. Phosphorylation of GAP-43 (growth-associated protein of 43 kDa) by conventional, novel and atypical isotypes of the protein kinase C gene family: differences between oligopeptide and polypeptide phosphorylation. Biochem J. 1996;317 ( Pt 1):219-24 pubmed
    ..These results suggest that there are multiple sites of interaction between GAP-43 and PKC. ..
  52. Ma W, Koch J, Viveiros M. Protein kinase C delta (PKCdelta) interacts with microtubule organizing center (MTOC)-associated proteins and participates in meiotic spindle organization. Dev Biol. 2008;320:414-25 pubmed publisher
    ..In this study the potential role of protein kinase C delta (PKCdelta) on meiotic spindle organization was evaluated in mouse oocytes...
  53. Bertram A, Zhang H, von Vietinghoff S, de Pablo C, Haller H, Shushakova N, et al. Protein kinase C-? is required for murine neutrophil recruitment and adhesion strengthening under flow. J Immunol. 2012;188:4043-51 pubmed publisher
    ..These findings suggest that the role of PKC-? in outside-in signaling following engagement of neutrophil integrins is relevant for inflammation in vivo. ..
  54. Strasser D, Neumann K, Bergmann H, Marakalala M, Guler R, Rojowska A, et al. Syk kinase-coupled C-type lectin receptors engage protein kinase C-σ to elicit Card9 adaptor-mediated innate immunity. Immunity. 2012;36:32-42 pubmed publisher
    ..b>Prkcd(-/-) dendritic cells, but not those lacking PKCα, PKCβ, or PKCθ, were defective in innate responses to ..
  55. Baig M, Liu D, Muthu K, Roy A, Saqib U, Naim A, et al. Heterotrimeric complex of p38 MAPK, PKCδ, and TIRAP is required for AP1 mediated inflammatory response. Int Immunopharmacol. 2017;48:211-218 pubmed publisher
    ..studied the novel mechanism of p38 MAPK activation through the formation of a heterotrimeric complex of Protein kinase C delta type (PKCδ), Toll-Interleukin 1 Receptor (TIR) Domain Containing Adaptor Protein (TIRAP), and p38 ..
  56. Brutman Barazani T, Horovitz Fried M, Aga Mizrachi S, Brand C, Brodie C, Rosa J, et al. Protein kinase C? but not PKC? is involved in insulin-induced glucose metabolism in hepatocytes. J Cell Biochem. 2012;113:2064-76 pubmed publisher
    ..We conclude that PKC?, but not PKC?, plays an essential role in insulin-induced glucose uptake and glycogenesis in hepatocytes. ..
  57. Grossoni V, Falbo K, Kazanietz M, de Kier Joffé E, Urtreger A. Protein kinase C delta enhances proliferation and survival of murine mammary cells. Mol Carcinog. 2007;46:381-90 pubmed
    ..In this study we show that in murine NMuMG mammary cells PKCdelta promotes a mitogenic response...
  58. Jin H, Kanthasamy A, Harischandra D, Kondru N, Ghosh A, Panicker N, et al. Histone hyperacetylation up-regulates protein kinase Cδ in dopaminergic neurons to induce cell death: relevance to epigenetic mechanisms of neurodegeneration in Parkinson disease. J Biol Chem. 2014;289:34743-67 pubmed publisher
    ..Together, these results indicate that histone acetylation regulates PKCδ expression to augment nigrostriatal dopaminergic cell death, which could contribute to the progressive neuropathogenesis of Parkinson disease. ..
  59. Jelacic T, Linnekin D. PKCdelta plays opposite roles in growth mediated by wild-type Kit and an oncogenic Kit mutant. Blood. 2005;105:1923-9 pubmed
    ..Here we investigate the role of protein kinase Cdelta (PKCdelta) in responses mediated by wild-type murine Kit and the D814Y mutant in a murine mast cell-like line...
  60. Cheng N, He R, Tian J, Dinauer M, Ye R. A critical role of protein kinase C delta activation loop phosphorylation in formyl-methionyl-leucyl-phenylalanine-induced phosphorylation of p47(phox) and rapid activation of nicotinamide adenine dinucleotide phosphate oxidase. J Immunol. 2007;179:7720-8 pubmed
    ..In this study, we report that PKCdelta phosphorylation in its activation loop is rapidly induced by fMLF and is essential for its ability to catalyze ..
  61. Kumar V, Weng Y, Geldenhuys W, Wang D, Han X, Messing R, et al. Generation and characterization of ATP analog-specific protein kinase Cδ. J Biol Chem. 2015;290:1936-51 pubmed publisher
    ..Such homology modeling could prove useful in designing molecules to target PKCδ and other kinases to understand their function in cell signaling and to identify unique substrates. ..
  62. Joseloff E, Cataisson C, Aamodt H, Ocheni H, Blumberg P, Kraker A, et al. Src family kinases phosphorylate protein kinase C delta on tyrosine residues and modify the neoplastic phenotype of skin keratinocytes. J Biol Chem. 2002;277:12318-23 pubmed
  63. Griner E, Caino M, Sosa M, Colon Gonzalez F, Chalmers M, Mischak H, et al. A novel cross-talk in diacylglycerol signaling: the Rac-GAP beta2-chimaerin is negatively regulated by protein kinase Cdelta-mediated phosphorylation. J Biol Chem. 2010;285:16931-41 pubmed publisher
  64. Lee Y, Lee D, Cho C, Bae S, Jhon G, Lee S, et al. HSP25 inhibits protein kinase C delta-mediated cell death through direct interaction. J Biol Chem. 2005;280:18108-19 pubmed
    ..HSP25 binds to kinase-active PKCdelta to inhibit its kinase activity and translocation to the membrane, which results in reduced cell death...
  65. Almind K, Kulkarni R, Lannon S, Kahn C. Identification of interactive loci linked to insulin and leptin in mice with genetic insulin resistance. Diabetes. 2003;52:1535-43 pubmed