Gene Symbol: Prkar1b
Description: protein kinase, cAMP dependent regulatory, type I beta
Alias: AI385716, RIbeta, cAMP-dependent protein kinase type I-beta regulatory subunit, cAMP dependent regulatory type I beta subunit transcript 1, cAMP dependent regulatory type I beta subunit transcript 2, cAMP dependent regulatory type I beta subunit transcript 3, cAMP dependent regulatory type I beta subunit transcript 4
Species: mouse
Products:     Prkar1b

Top Publications

  1. Zhou T, Li J, Zhao P, Liu H, Jia D, Jia H, et al. Palmitoyl acyltransferase Aph2 in cardiac function and the development of cardiomyopathy. Proc Natl Acad Sci U S A. 2015;112:15666-71 pubmed publisher
    ..These findings establish Aph2 as a critical in vivo regulator of cardiac function and reveal roles for protein palmitoylation in the development of other organs including eyes. ..
  2. Banday A, Azim S, Rehman S, Tabish M. Two novel N-terminal coding exons of Prkar1b gene of mouse: identified using a novel approach of in silico and molecular biology techniques. Gene. 2012;500:73-9 pubmed publisher
    The Prkar1b gene encodes regulatory type 1 beta subunit of protein kinase A...
  3. Watson R, Abdel Majid R, Barnett M, Willis B, Katsnelson A, Gillingwater T, et al. Involvement of protein kinase A in patterning of the mouse somatosensory cortex. J Neurosci. 2006;26:5393-401 pubmed
    ..These results give insight into activity-dependent mechanisms that regulate barrel formation. ..
  4. Hensch T, Gordon J, Brandon E, McKnight G, Idzerda R, Stryker M. Comparison of plasticity in vivo and in vitro in the developing visual cortex of normal and protein kinase A RIbeta-deficient mice. J Neurosci. 1998;18:2108-17 pubmed
    ..In mice lacking the RIbeta regulatory subunit of PKA, we observed three abnormalities of synaptic plasticity in layer II/III of visual cortex ..
  5. Kurosu T, Hernandez A, Wolk J, Liu J, Schwartz J. Alpha/beta-tubulin are A kinase anchor proteins for type I PKA in neurons. Brain Res. 2009;1251:53-64 pubmed publisher
    ..These observations suggest that the alpha/beta-tubulin anchoring type I PKA may have an important role in the formation of long-term synaptic plasticity. ..
  6. Ueyama T, Lennartz M, Noda Y, Kobayashi T, Shirai Y, Rikitake K, et al. Superoxide production at phagosomal cup/phagosome through beta I protein kinase C during Fc gamma R-mediated phagocytosis in microglia. J Immunol. 2004;173:4582-9 pubmed
    ..This study also suggests that DGKbeta plays a prominent role in regulation of O(2)(-) production during FcgammaR-mediated phagocytosis. ..
  7. Malmberg A, Brandon E, Idzerda R, Liu H, McKnight G, Basbaum A. Diminished inflammation and nociceptive pain with preservation of neuropathic pain in mice with a targeted mutation of the type I regulatory subunit of cAMP-dependent protein kinase. J Neurosci. 1997;17:7462-70 pubmed
    ..carry a null mutation in the gene that encodes the neuronal-specific isoform of the type I regulatory subunit (RIbeta) of PKA. Acute pain indices did not differ in the RIbeta PKA mutant mice compared with wild-type controls...
  8. Brandon E, Gerhold K, Qi M, McKnight G, Idzerda R. Derivation of novel embryonic stem cell lines and targeting of cyclic AMP-dependent protein kinase genes. Recent Prog Horm Res. 1995;50:403-8 pubmed
  9. Solberg R, Tasken K, Keiserud A, Jahnsen T. Molecular cloning, cDNA structure and tissue-specific expression of the human regulatory subunit RI beta of cAMP-dependent protein kinases. Biochem Biophys Res Commun. 1991;176:166-72 pubmed
    ..7 kb mRNA in human tissues and a 2.8 kb mRNA in mouse tissues. Both mouse and human RI beta mRNA were found to be expressed in most tissues, and not restricted to brain and testis as reported by others. ..

More Information


  1. Huang Y, Kandel E, Varshavsky L, Brandon E, Qi M, Idzerda R, et al. A genetic test of the effects of mutations in PKA on mossy fiber LTP and its relation to spatial and contextual learning. Cell. 1995;83:1211-22 pubmed
    ..In the absence of mossy fiber LTP, adequate spatial and contextual information might reach the CA1 region via other pathways from the entorhinal cortex. ..
  2. Imaizumi Scherrer T, Faust D, Benichou J, Hellio R, Weiss M. Accumulation in fetal muscle and localization to the neuromuscular junction of cAMP-dependent protein kinase A regulatory and catalytic subunits RI alpha and C alpha. J Cell Biol. 1996;134:1241-54 pubmed
    ..In the adult, the C alpha hybridization signal of muscle is weak and homogeneous...
  3. Clegg C, Koeiman N, Jenkins N, Gilbert D, Copeland N, Neubauer M. Structural features of the murine gene encoding the RI beta subunit of cAMP-dependent protein kinase. Mol Cell Neurosci. 1994;5:153-64 pubmed
    ..The mouse chromosomal locus (designated Prkar1b) was determined by interspecific backcross mapping and found to reside on the distal arm of chromosome 5...
  4. Rogers K, Boring L, McKnight G, Clegg C. Promoter for the regulatory type I beta subunit of the 3',5'-cyclic adenosine monophosphate-dependent protein kinase directs transgene expression in the central nervous system. Mol Endocrinol. 1992;6:1756-65 pubmed
    ..This promoter can also be used to target the expression of wild type and mutant cAPK subunit genes in order to investigate synaptic plasticity in animals. ..
  5. Krizhanovsky V, Soreq L, Kliminski V, Ben Arie N. Math1 target genes are enriched with evolutionarily conserved clustered E-box binding sites. J Mol Neurosci. 2006;28:211-29 pubmed
    ..Our findings may be useful to the study of other bHLH transcription factors, many of which control the development of the nervous system. ..
  6. Ilouz R, Bubis J, Wu J, Yim Y, Deal M, Kornev A, et al. Localization and quaternary structure of the PKA RI? holoenzyme. Proc Natl Acad Sci U S A. 2012;109:12443-8 pubmed publisher
    ..The creation of discrete isoform-specific PKA holoenzyme signaling "foci" paves the way for exploring further biological roles of PKA RI? and establishes a paradigm for PKA signaling. ..
  7. Clegg C, Haugen H, Boring L. Promoter sequences in the RI beta subunit gene of cAMP-dependent protein kinase required for transgene expression in mouse brain. J Biol Chem. 1996;271:1638-44 pubmed
    ..These results have identified specific regions of the RI beta promoter that are required for the expression of this signal transduction protein in mouse neurons. ..
  8. Woldeyesus M, Britsch S, Riethmacher D, Xu L, Sonnenberg Riethmacher E, Abou Rebyeh F, et al. Peripheral nervous system defects in erbB2 mutants following genetic rescue of heart development. Genes Dev. 1999;13:2538-48 pubmed
    ..Our results define the roles of Schwann cells during motoneuron and synapse development, and reveal different survival requirements for distinct motoneuron populations. ..
  9. Mucignat Caretta C, Caretta A. Localization of Triton-insoluble cAMP-dependent kinase type RIbeta in rat and mouse brain. J Neurocytol. 2001;30:885-94 pubmed
    ..By immunohistochemistry, the distribution of the detergent-insoluble fraction of RIbeta isoform has been examined in rat and mouse brain...
  10. Greene R, Lloyd M, Uberti M, Nugent P, Pisano M. Patterns of cyclic AMP-dependent protein kinase gene expression during ontogeny of the murine palate. J Cell Physiol. 1995;163:431-40 pubmed
    ..In addition, we have demonstrated adaptational changes of this kinase in MEPM cells in response to conditions of increased intracellular levels of cAMP. ..
  11. Brandon E, Zhuo M, Huang Y, Qi M, Gerhold K, Burton K, et al. Hippocampal long-term depression and depotentiation are defective in mice carrying a targeted disruption of the gene encoding the RI beta subunit of cAMP-dependent protein kinase. Proc Natl Acad Sci U S A. 1995;92:8851-5 pubmed
  12. Zhong H, Sia G, Sato T, Gray N, Mao T, Khuchua Z, et al. Subcellular dynamics of type II PKA in neurons. Neuron. 2009;62:363-74 pubmed publisher
    ..Therefore, the localization and activity-dependent translocation of type II PKA are important determinants of PKA function. ..
  13. Banday A, Azim S, Tabish M. Differentially expressed three non-coding alternate exons at 5' UTR of regulatory type I beta subunit gene of mouse. Mol Biol Rep. 2012;39:3375-83 pubmed publisher
    b>Prkar1b gene encodes regulatory type I, beta subunit (RI?) of cAMP dependent protein kinase A in mouse...
  14. Clegg C, Cadd G, McKnight G. Genetic characterization of a brain-specific form of the type I regulatory subunit of cAMP-dependent protein kinase. Proc Natl Acad Sci U S A. 1988;85:3703-7 pubmed
    ..RI beta protein produced in 3T3 cells was shown to be functional by its ability to form a cAMP-dependent holoenzyme with the catalytic subunit. ..