Prkaa2

Summary

Gene Symbol: Prkaa2
Description: protein kinase, AMP-activated, alpha 2 catalytic subunit
Alias: 2310008I11Rik, A830082D05, AMPKalpha2, 5'-AMP-activated protein kinase catalytic subunit alpha-2, ACACA kinase, AMP-activated protein kinase alpha-2 variant B, AMPK subunit alpha-2, HMGCR kinase, acetyl-CoA carboxylase kinase, hydroxymethylglutaryl-CoA reductase kinase
Species: mouse

Top Publications

  1. ncbi Induced adiposity and adipocyte hypertrophy in mice lacking the AMP-activated protein kinase-alpha2 subunit
    Josep A Villena
    Department of Nutritional Sciences and Toxicology, University of California, Berkeley, CA 94720
    Diabetes 53:2242-9. 2004
  2. ncbi AMP-activated protein kinase induces a p53-dependent metabolic checkpoint
    Russell G Jones
    Abramson Family Cancer Research Institute, Department of Cancer Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Mol Cell 18:283-93. 2005
  3. pmc 5'-AMP-activated protein kinase (AMPK) is induced by low-oxygen and glucose deprivation conditions found in solid-tumor microenvironments
    Keith R Laderoute
    SRI International, Bldg L, Rm A258, 333 Ravenswood Ave, Menlo Park, CA 94025, USA
    Mol Cell Biol 26:5336-47. 2006
  4. pmc Leptin stimulates fatty acid oxidation and peroxisome proliferator-activated receptor alpha gene expression in mouse C2C12 myoblasts by changing the subcellular localization of the alpha2 form of AMP-activated protein kinase
    Atsushi Suzuki
    Division of Endocrinology and Metabolism, Department of Developmental Physiology, National Institute for Physiological Sciences, 38 Nishigonaka, Myodaiji, Okazaki, Aichi, Japan
    Mol Cell Biol 27:4317-27. 2007
  5. pmc Upregulation of mitochondrial uncoupling protein-2 by the AMP-activated protein kinase in endothelial cells attenuates oxidative stress in diabetes
    Zhonglin Xie
    Division of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
    Diabetes 57:3222-30. 2008
  6. pmc The L-4F mimetic peptide prevents insulin resistance through increased levels of HO-1, pAMPK, and pAKT in obese mice
    Stephen J Peterson
    Department of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
    J Lipid Res 50:1293-304. 2009
  7. pmc AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation
    Katja A Lamia
    Gene Expression Laboratory, The Salk Institute, La Jolla, CA 92037, USA
    Science 326:437-40. 2009
  8. pmc Compound C inhibits hypoxic activation of HIF-1 independent of AMPK
    Brooke M Emerling
    Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    FEBS Lett 581:5727-31. 2007
  9. pmc Deficiency of insulin-like growth factor 1 reduces sensitivity to aging-associated cardiomyocyte dysfunction
    Qun Li
    Division of Pharmaceutical Sciences and Center for Cardiovascular Research and Alternative Medicine, University of Wyoming, Laramie, WY 82071, USA
    Rejuvenation Res 11:725-33. 2008
  10. pmc AMPKalpha2 deletion causes aberrant expression and activation of NAD(P)H oxidase and consequent endothelial dysfunction in vivo: role of 26S proteasomes
    Shuangxi Wang
    Section of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA
    Circ Res 106:1117-28. 2010

Scientific Experts

Detail Information

Publications108 found, 100 shown here

  1. ncbi Induced adiposity and adipocyte hypertrophy in mice lacking the AMP-activated protein kinase-alpha2 subunit
    Josep A Villena
    Department of Nutritional Sciences and Toxicology, University of California, Berkeley, CA 94720
    Diabetes 53:2242-9. 2004
    ..In the present study, we subjected AMPKalpha2 knockout (KO) mice to a high-fat diet to examine the effect of AMPK on adipose tissue formation...
  2. ncbi AMP-activated protein kinase induces a p53-dependent metabolic checkpoint
    Russell G Jones
    Abramson Family Cancer Research Institute, Department of Cancer Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Mol Cell 18:283-93. 2005
    ..However, persistent activation of AMPK leads to accelerated p53-dependent cellular senescence. Thus, AMPK is a cell-intrinsic regulator of the cell cycle that coordinates cellular proliferation with carbon source availability...
  3. pmc 5'-AMP-activated protein kinase (AMPK) is induced by low-oxygen and glucose deprivation conditions found in solid-tumor microenvironments
    Keith R Laderoute
    SRI International, Bldg L, Rm A258, 333 Ravenswood Ave, Menlo Park, CA 94025, USA
    Mol Cell Biol 26:5336-47. 2006
    ..We also showed that AMPK is important for the growth of this tumor model...
  4. pmc Leptin stimulates fatty acid oxidation and peroxisome proliferator-activated receptor alpha gene expression in mouse C2C12 myoblasts by changing the subcellular localization of the alpha2 form of AMP-activated protein kinase
    Atsushi Suzuki
    Division of Endocrinology and Metabolism, Department of Developmental Physiology, National Institute for Physiological Sciences, 38 Nishigonaka, Myodaiji, Okazaki, Aichi, Japan
    Mol Cell Biol 27:4317-27. 2007
    ..Our data thus suggest that the activation of and changes in the subcellular localization of alpha2AMPK are required for leptin-induced stimulation of fatty acid oxidation and PPARalpha gene expression in muscle cells...
  5. pmc Upregulation of mitochondrial uncoupling protein-2 by the AMP-activated protein kinase in endothelial cells attenuates oxidative stress in diabetes
    Zhonglin Xie
    Division of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
    Diabetes 57:3222-30. 2008
    ..The present study was conducted to determine how AMPK activation suppressed tyrosine nitration of prostacyclin synthase in diabetes...
  6. pmc The L-4F mimetic peptide prevents insulin resistance through increased levels of HO-1, pAMPK, and pAKT in obese mice
    Stephen J Peterson
    Department of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
    J Lipid Res 50:1293-304. 2009
    ..The anti-obesity effects of L-4F are manifested by a decrease in visceral fat content with reciprocal increases in adiponectin, pAMPK, pAKT, and phosphorylation of insulin receptors with improved insulin sensitivity...
  7. pmc AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation
    Katja A Lamia
    Gene Expression Laboratory, The Salk Institute, La Jolla, CA 92037, USA
    Science 326:437-40. 2009
    ..Thus, phosphorylation by AMPK enables cryptochrome to transduce nutrient signals to circadian clocks in mammalian peripheral organs...
  8. pmc Compound C inhibits hypoxic activation of HIF-1 independent of AMPK
    Brooke M Emerling
    Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    FEBS Lett 581:5727-31. 2007
    ..Furthermore, we demonstrate that Compound C functions as a repressor of HIF-1 by inhibiting respiration and suppressing mitochondrial generated ROS...
  9. pmc Deficiency of insulin-like growth factor 1 reduces sensitivity to aging-associated cardiomyocyte dysfunction
    Qun Li
    Division of Pharmaceutical Sciences and Center for Cardiovascular Research and Alternative Medicine, University of Wyoming, Laramie, WY 82071, USA
    Rejuvenation Res 11:725-33. 2008
    ..Our data suggest that regulation of Akt, p53, adenosine monophosphate-activated protein kinase (AMPK) phosphorylation, and Klotho may play a role, at least in part, in IGF-1 deficiency-induced "desensitization" of cardiac aging...
  10. pmc AMPKalpha2 deletion causes aberrant expression and activation of NAD(P)H oxidase and consequent endothelial dysfunction in vivo: role of 26S proteasomes
    Shuangxi Wang
    Section of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA
    Circ Res 106:1117-28. 2010
    ..Recent studies suggest that AMPK activation improves endothelial function by counteracting oxidative stress in endothelial cells. How AMPK suppresses oxidative stress remains to be established...
  11. ncbi Knockout of the alpha2 but not alpha1 5'-AMP-activated protein kinase isoform abolishes 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranosidebut not contraction-induced glucose uptake in skeletal muscle
    Sebastian B Jørgensen
    Copenhagen Muscle Research Centre, Department of Human Physiology, 13 Universitetsparken, University of Copenhagen, DK 2100 Copenhagen, Denmark
    J Biol Chem 279:1070-9. 2004
    ..Alternatively, neither alpha-isoform of AMPK is involved in contraction-induced muscle glucose uptake...
  12. pmc The AMP-activated protein kinase alpha2 catalytic subunit controls whole-body insulin sensitivity
    Benoit Viollet
    Department of Genetic, Development, and Molecular Pathology, Institut National de la Sante et de la Recherche Medicale INSERM, Centre National de la Recherche Scientifique CNRS, Rene Descartes University, Paris, France
    J Clin Invest 111:91-8. 2003
    ..To better understand the physiological role of AMPK, we generated a knockout mouse model in which the AMPKalpha2 catalytic subunit gene was inactivated...
  13. pmc AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons
    Marc Claret
    Centre for Diabetes and Endocrinology, Rayne Institute, University College London, London, United Kingdom
    J Clin Invest 117:2325-36. 2007
    ....
  14. ncbi Diet-induced obesity alters AMP kinase activity in hypothalamus and skeletal muscle
    Tonya L Martin
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 281:18933-41. 2006
    ..Defective responses of AMPK to leptin may contribute to resistance to leptin action on food intake and energy expenditure in obese states...
  15. ncbi Akt activity negatively regulates phosphorylation of AMP-activated protein kinase in the heart
    Suzanne Kovacic
    Molecular Cardiology, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118 2256, USA
    J Biol Chem 278:39422-7. 2003
    ..In addition, our data suggest that the ability of insulin to inhibit AMPK may be controlled via an Akt-mediated mechanism...
  16. ncbi 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside and metformin inhibit hepatic glucose phosphorylation by an AMP-activated protein kinase-independent effect on glucokinase translocation
    Bruno Guigas
    Hormone and Metabolic Research Unit, Institute of Cellular Pathology, UCL 7529, Avenue Hippocrate 75, 1200 Brussels, Belgium
    Diabetes 55:865-74. 2006
    ....
  17. ncbi Activation of 5'-AMP-activated kinase with diabetes drug metformin induces casein kinase Iepsilon (CKIepsilon)-dependent degradation of clock protein mPer2
    Jee Hyun Um
    Laboratory of Biochemical Genetics, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 282:20794-8. 2007
    ..We conclude that metformin and AMPK have a previously unrecognized role in regulating the circadian rhythm...
  18. pmc Activation of AMP-activated protein kinase alpha1 alleviates endothelial cell apoptosis by increasing the expression of anti-apoptotic proteins Bcl-2 and survivin
    Chao Liu
    Section of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    J Biol Chem 285:15346-55. 2010
    ..Finally, we found that genetic deletion of the AMPKalpha1, but not AMPKalpha2, suppressed OGD-enhanced NF-kappaB activation, the expression of Bcl-2 and Survivin, and endothelial apoptosis...
  19. pmc Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms
    Aram F Hezel
    MGH Cancer Center, Simches Research Building, CPZN 4216, 185 Cambridge St, Boston, MA 02114, USA
    Mol Cell Biol 28:2414-25. 2008
    ..These genetic studies provide in vivo evidence of a key role for LKB1 in the establishment of epithelial cell polarity that is vital for pancreatic acinar cell function and viability and for the suppression of neoplasia...
  20. pmc AMPK phosphorylation of raptor mediates a metabolic checkpoint
    Dana M Gwinn
    Molecular and Cell Biology Laboratory, Dulbecco Center for Cancer Research, Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Mol Cell 30:214-26. 2008
    ..These findings uncover a conserved effector of AMPK that mediates its role as a metabolic checkpoint coordinating cell growth with energy status...
  21. ncbi Activation of the AMP-activated kinase by antidiabetes drug metformin stimulates nitric oxide synthesis in vivo by promoting the association of heat shock protein 90 and endothelial nitric oxide synthase
    Bradley J Davis
    Vascular Research Laboratory, Department of Surgery, Graduate School of Medicine, University of Tennessee, Knoxville, USA
    Diabetes 55:496-505. 2006
    ..Taken together, our results indicate that metformin might improve vascular endothelial functions in diabetes by increasing AMPK-dependent, hsp90-mediated eNOS activation...
  22. pmc Identification of nitric oxide as an endogenous activator of the AMP-activated protein kinase in vascular endothelial cells
    Junhua Zhang
    Division of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    J Biol Chem 283:27452-61. 2008
    ..Taken together, we conclude that NO might act as an endogenous AMPK activator...
  23. ncbi AMPK-mediated AS160 phosphorylation in skeletal muscle is dependent on AMPK catalytic and regulatory subunits
    Jonas T Treebak
    Department of Molecular Medicine and Surgery, Section for Integrative Physiology, Karolinska Institute, von Eulers vag 4, 4th Floor, S 171 77 Stockholm, Sweden
    Diabetes 55:2051-8. 2006
    ..Contraction-mediated AS160 phosphorylation was also impaired in alpha2 AMPK KO and KD but not gamma3 AMPK KO mice. Our results implicate AS160 as a downstream target of AMPK...
  24. ncbi AMP-activated protein kinase alpha2 activity is not essential for contraction- and hyperosmolarity-induced glucose transport in skeletal muscle
    Nobuharu Fujii
    Research Division, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 280:39033-41. 2005
    ..Muscle contraction- and hyperosmolarity-induced glucose transport may be regulated by a redundant mechanism in which AMPK alpha2 is one of multiple signaling pathways...
  25. ncbi Liver adenosine monophosphate-activated kinase-alpha2 catalytic subunit is a key target for the control of hepatic glucose production by adiponectin and leptin but not insulin
    Fabrizio Andreelli
    Institut National de la Santé et de la Recherche Médicale Unité 567, Centre National de la Recherche Scientifique Unite Mixte de Recherche 8104, Universite Rene Descartes Paris 5, France
    Endocrinology 147:2432-41. 2006
    ..Here we studied how hepatic AMPKalpha2 isoform affects hepatic glucose production and peripheral glucose uptake in vivo...
  26. pmc AMP-activated protein kinase-independent inhibition of hepatic mitochondrial oxidative phosphorylation by AICA riboside
    Bruno Guigas
    Université catholique de Louvain and Institute of Cellular Pathology, Hormone and Metabolic Research Unit, Brussels, Belgium
    Biochem J 404:499-507. 2007
    ..Our data also demonstrate that the cellular effects of AICA riboside are not necessarily caused by AMPK activation and that their interpretation should be taken with caution...
  27. ncbi Short-term overexpression of a constitutively active form of AMP-activated protein kinase in the liver leads to mild hypoglycemia and fatty liver
    Marc Foretz
    Institut Cochin, Département de génétique, Developpement et Pathologie Moleculaire, Universite Rene Descartes Paris 5, Institut National de la Sante et de la Recherche Medicale U567, Centre National de la Recherche Scientifique UMR8104, Paris, France
    Diabetes 54:1331-9. 2005
    ..specifically in the liver by adenovirus-mediated transfer of a gene encoding a constitutively active form of AMPKalpha2 (AMPKalpha2-CA)...
  28. pmc AMP kinase regulation of sugar transport in brain capillary endothelial cells during acute metabolic stress
    Anthony J Cura
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, USA
    Am J Physiol Cell Physiol 303:C806-14. 2012
    ....
  29. pmc AMP-activated protein kinase suppresses matrix metalloproteinase-9 expression in mouse embryonic fibroblasts
    Yuki Morizane
    Retina Service, Angiogenesis Laboratory, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Biol Chem 286:16030-8. 2011
    ..Overall, our results suggest that both AMPKα isoforms suppress MMP-9 expression and that both the activity and presence of AMPKα contribute to its function as a regulator of MMP-9 expression by inhibiting the NF-κB pathway...
  30. pmc Activation of AMP-activated protein kinase by vascular endothelial growth factor mediates endothelial angiogenesis independently of nitric-oxide synthase
    Nadine Stahmann
    Institute for Molecular Cell Biology, Center for Molecular Biomedicine, Friedrich Schiller University of Jena, 07745 Jena, Germany
    J Biol Chem 285:10638-52. 2010
    ..To investigate the role of AMPK in endothelial function, CaMKKbeta, AMPKalpha1, or AMPKalpha2 was down-regulated by RNA interference, and studies in AMPKalpha1(-/-) mice were performed...
  31. pmc Metabolic regulation of neuronal plasticity by the energy sensor AMPK
    Wyatt B Potter
    Department of Neurology, University of Wisconsin Madison, Madison, Wisconsin, United States of America
    PLoS ONE 5:e8996. 2010
    ..Our work opens up the possibility of using modulators of energy metabolism to control neuronal plasticity in diseases and conditions of aberrant plasticity such as epilepsy...
  32. pmc AMPK-dependent phosphorylation of ULK1 regulates ATG9 localization
    Hildegard I D Mack
    Cancer Biology Program, Division of Hematology Oncology, Department of Medicine Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    Autophagy 8:1197-214. 2012
    ..Taken together these data identify an ULK1-AMPK signaling cassette involved in regulation of the autophagy machinery...
  33. ncbi Antagonistic control of muscle cell size by AMPK and mTORC1
    Remi Mounier
    Inserm U1016, Centre National de la Recherche Scientifique CNRS, UMR8104, University Paris Descartes, Institut Cochin, Paris, France
    Cell Cycle 10:2640-6. 2011
    ..Thus, the crosstalk between AMPK and mTORC1 signaling is a highly regulated way to control changes in muscle growth and metabolic rate imposed by external cues...
  34. pmc AMPK is a negative regulator of the Warburg effect and suppresses tumor growth in vivo
    Brandon Faubert
    Department of Physiology, McGill University, Montreal, QC, H3G 1Y6, Canada
    Cell Metab 17:113-24. 2013
    ..Together our findings suggest that AMPK activity opposes tumor development and that its loss fosters tumor progression in part by regulating cellular metabolic pathways that support cell growth and proliferation...
  35. pmc AMPKalpha1 deletion shortens erythrocyte life span in mice: role of oxidative stress
    Shaobin Wang
    Division of Endocrinology and Diabetes, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma 73104, USA
    J Biol Chem 285:19976-85. 2010
    ..in murine erythrocytes and mice globally deficient in AMPKalpha1 (AMPKalpha1(-/-)), but not in those lacking AMPKalpha2, and the mice had markedly enlarged spleens with dramatically increased proportions of Ter119-positive erythroid ..
  36. pmc AMPK attenuates microtubule proliferation in cardiac hypertrophy
    John T Fassett
    Cardiovascular Division, University of Minnesota Medical School, Minneapolis, MN, USA
    Am J Physiol Heart Circ Physiol 304:H749-58. 2013
    ....
  37. pmc Cells lacking the fumarase tumor suppressor are protected from apoptosis through a hypoxia-inducible factor-independent, AMPK-dependent mechanism
    Chiara Bardella
    Department of Oncological Sciences, University of Torino, School of Medicine, Turin, Italy
    Mol Cell Biol 32:3081-94. 2012
    ..These findings reveal a new mechanism of tumorigenesis due to FH loss and an unexpected pro-oncogenic role for AMPK that is important in considering AMPK reactivation as a therapeutic strategy against cancer...
  38. pmc The asparaginyl hydroxylase factor inhibiting HIF-1alpha is an essential regulator of metabolism
    Na Zhang
    Molecular Biology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA
    Cell Metab 11:364-78. 2010
    ..These results demonstrate that FIH acts to a significant degree through the nervous system to regulate metabolism...
  39. pmc Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state
    Marc Foretz
    Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, Paris, France
    J Clin Invest 120:2355-69. 2010
    ..In conclusion, we demonstrate that metformin inhibits hepatic gluconeogenesis in an LKB1- and AMPK-independent manner via a decrease in hepatic energy state...
  40. pmc AMP-activated protein kinase restricts IFN-γ signaling
    Gordon P Meares
    Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 190:372-80. 2013
    ..Overall, these findings provide the first link between AMPK and STAT1 and may provide important clues about how bioenergetics and inflammation are linked...
  41. pmc Glucagon regulates ACC activity in adipocytes through the CAMKKβ/AMPK pathway
    I Chen Peng
    Division of Biomedical Sciences, University of California, Riverside, 92521, USA
    Am J Physiol Endocrinol Metab 302:E1560-8. 2012
    ..These results indicate that CaMKKβ/AMPK signaling is an important molecular component in regulating lipid metabolism in adipocytes responding to glucagon and could be a therapeutic target for the dysregulation of energy storage...
  42. pmc Benzo(a)pyrene causes PRKAA1/2-dependent ID2 loss in trophoblast stem cells
    Yufen Xie
    CS Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit, Michigan
    Mol Reprod Dev 77:533-9. 2010
    ..The threshold BaP dose that induces significant ID2 loss is in the range of a 2-3 pack/day habit, suggesting that this mechanism may be involved with implantation failure in smoking women...
  43. pmc Loss of AMP-activated protein kinase alpha2 subunit in mouse beta-cells impairs glucose-stimulated insulin secretion and inhibits their sensitivity to hypoglycaemia
    Craig Beall
    Biomedical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK
    Biochem J 429:323-33. 2010
    ..These results show that AMPK alpha2 activity is necessary to maintain normal pancreatic beta-cell glucose sensing, possibly by maintaining high beta-cell levels of UCP2...
  44. doi Differential regulation of eEF2 and p70S6K by AMPKalpha2 in heart
    Bénédicte Demeulder
    Universite Catholique de Louvain, Institut de Recherche Expérimentale et Clinique, Pôle de Recherche Cardiovasculaire, Avenue Hippocrate, 55, B1 55 05, 1200 Brussels, Belgium
    Biochim Biophys Acta 1832:780-90. 2013
    ..This challenges the accepted notion that mTOR-p70S6K is inhibited by myocardial ischemia mainly via an AMPK-dependent mechanism...
  45. pmc Exercise-induced TBC1D1 Ser237 phosphorylation and 14-3-3 protein binding capacity in human skeletal muscle
    Christian Frøsig
    Molecular Physiology Group, Department of Exercise and Sport Sciences, University of Copenhagen, DK 2100 Copenhagen, Denmark
    J Physiol 588:4539-48. 2010
    ..Furthermore, we show that the catalytic α2 AMPK subunit is the main (but probably not the only) donor of AMPK activity regulating TBC1D1 Ser237 phosphorylation in mouse EDL muscle...
  46. doi Genetic impairment of AMPKalpha2 signaling does not reduce muscle glucose uptake during treadmill exercise in mice
    Stine J Maarbjerg
    Department of Exercise and Sport Sciences, Copenhagen Muscle Research Centre, University of Copenhagen, Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 297:E924-34. 2009
    ..We studied this in male and female mice overexpressing kinase-dead AMPKalpha2 (AMPK-KD) in skeletal and heart muscles...
  47. pmc Effects of WY-14,643 on the phosphorylation and activation of AMP-dependent protein kinase
    Suthat Liangpunsakul
    Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine and Roudebush Veterans Administration Medical Center, 545 N Barnhill Drive, Indianapolis, IN 46202, USA
    Arch Biochem Biophys 485:10-5. 2009
    ..Whether WY-14,643, a PPARalpha agonist, has any effects on AMPK is not known. The aim of this study was to investigate the effect of WY-14,643 on AMPK activity...
  48. doi Activation of AMP-activated protein kinase is involved in vincristine-induced cell apoptosis in B16 melanoma cell
    Min Bin Chen
    Department of Medical Oncology, Kunshan First People s Hospital Affiliated to Jiangsu University, Kunshan, Jiangsu Province, China
    J Cell Physiol 226:1915-25. 2011
    ..We suggest that combining AMPK activator AICAR with vincristine may have potential to be used as a new therapeutic intervention against melanoma...
  49. pmc Isoform-selective 5'-AMP-activated protein kinase-dependent preconditioning mechanisms to prevent postischemic leukocyte-endothelial cell adhesive interactions
    F Spencer Gaskin
    Departments of Medical Pharmacology and Physiology, University of Missouri, Columbia, 65212, USA
    Am J Physiol Heart Circ Physiol 300:H1352-60. 2011
    ..In sharp contrast, EPC appears to be triggered by an AMPK α(2)-isoform-dependent mechanism...
  50. pmc AMP-activated protein kinase functionally phosphorylates endothelial nitric oxide synthase Ser633
    Zhen Chen
    Division of Biomedical Sciences, University of California, Riverside, CA 92521, USA
    Circ Res 104:496-505. 2009
    ..The aorta of AMPKalpha2(-/-) mice showed attenuated atorvastatin-induced eNOS phosphorylation...
  51. doi Lkb1 is required for TGFbeta-mediated myofibroblast differentiation
    Kari Vaahtomeri
    Genome Scale Biology Program, Institute of Biomedicine, Biomedicum Helsinki, P O Box 63, 00014 University of Helsinki, Finland
    J Cell Sci 121:3531-40. 2008
    ..These results suggest that tumorigenesis by Lkb1-deficient SM22-positive cells involves defective myogenic differentiation...
  52. pmc AMP-activated protein kinase α2 subunit is required for the preservation of hepatic insulin sensitivity by n-3 polyunsaturated fatty acids
    Tomas Jelenik
    Department of Adipose Tissue Biology, Institute of Physiology of the Academy of Sciences of the Czech Republic, v v i, Prague, Czech Republic
    Diabetes 59:2737-46. 2010
    ..We tested a hypothesis whether AMP-activated protein kinase (AMPK) has a role in the beneficial effects of n-3 LC-PUFAs...
  53. pmc Human recombinant ACE2 reduces the progression of diabetic nephropathy
    Gavin Y Oudit
    Division of Cardiology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Diabetes 59:529-38. 2010
    ..Inhibition of ACE2 function accelerates diabetic kidney injury, whereas renal ACE2 is downregulated in diabetic nephropathy. We examined the ability of human recombinant ACE2 (hrACE2) to slow the progression of diabetic kidney injury...
  54. pmc PKA phosphorylates and inactivates AMPKalpha to promote efficient lipolysis
    Nabil Djouder
    Institute of Cell Biology, ETH Zurich, Zurich, Switzerland
    EMBO J 29:469-81. 2010
    ..These results suggest a new mechanism of negative regulation of AMPK activity by PKA that is important for converting a lipolytic signal into an effective lipolytic response...
  55. pmc Positive regulatory control loop between gut leptin and intestinal GLUT2/GLUT5 transporters links to hepatic metabolic functions in rodents
    Yassine Sakar
    INSERM, U773, Centre de recherche Biomedicale Bichat Beaujon, UFR de Médecine Paris 7 Denis Diderot, IFR02 Claude Bernard, Paris, France
    PLoS ONE 4:e7935. 2009
    ..In this study, we determine the effects of luminal leptin on activity/expression of GLUT2 and GLUT5 transporters in response to sugars intake and analyse their physiological consequences...
  56. doi Non-CDK-bound p27 (p27(NCDK)) is a marker for cell stress and is regulated through the Akt/PKB and AMPK-kinase pathways
    Mia A Björklund
    Molecular Cancer Biology Program, Biomedicum Helsinki and Haartman Institute, University of Helsinki, Helsinki, Finland
    Exp Cell Res 316:762-74. 2010
    ..These results indicate that p27(NCDK) is a sensitive marker for both cell stress and proliferation over and above p27 and is regulated by Akt/PKB and AMPK pathways...
  57. doi Ablation of AMP-activated protein kinase alpha1 and alpha2 from mouse pancreatic beta cells and RIP2.Cre neurons suppresses insulin release in vivo
    G Sun
    Section of Cell Biology, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, Sir Alexander Fleming Building, Exhibition Road, South Kensington, London, SW7 2AZ, UK
    Diabetologia 53:924-36. 2010
    ..AMP-activated protein kinase (AMPK) is an evolutionarily conserved enzyme and a target of glucose-lowering agents, including metformin. However, the precise role or roles of the enzyme in controlling insulin secretion remain uncertain...
  58. pmc Impaired expression of uncoupling protein 2 causes defective postischemic angiogenesis in mice deficient in AMP-activated protein kinase α subunits
    Ming jiang Xu
    Section of Molecular Medicine, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, 73104, USA
    Arterioscler Thromb Vasc Biol 31:1757-65. 2011
    ..The aim of the present study was to determine whether mitochondrial uncoupling protein (UCP) 2 is required for AMPK-dependent angiogenesis in ischemia in vivo...
  59. pmc AMP-activated protein kinase (AMPK) activation regulates in vitro bone formation and bone mass
    M Shah
    Department of Veterinary Basic Sciences Royal Veterinary College, Royal College Street, London, NW1 OTU, UK
    Bone 47:309-19. 2010
    ..Both cortical and trabecular bone compartments were smaller in the AMPK alpha1-deficient mice compared to the WT mice. Altogether, our data support a role for AMPK signalling in skeletal physiology...
  60. pmc Activation of AMP-activated protein kinase inhibits oxidized LDL-triggered endoplasmic reticulum stress in vivo
    Yunzhou Dong
    ection of Endocrinology and Diabetes, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
    Diabetes 59:1386-96. 2010
    ..Here we report that oxidized and glycated LDL (HOG-LDL) causes aberrant endoplasmic reticulum (ER) stress and that the AMP-activated protein kinase (AMPK) suppressed HOG-LDL-triggered ER stress in vivo...
  61. pmc Contraction-induced skeletal muscle FAT/CD36 trafficking and FA uptake is AMPK independent
    J Jeppesen
    Copenhagen Muscle Research Center, Molecular Physiology Group, Section of Human Physiology, University of Copenhagen, Copenhagen, Denmark
    J Lipid Res 52:699-711. 2011
    ..However, AMPK could be important in regulation of FAT/CD36 distribution in other physiological situations...
  62. pmc Stimulation of glucose transport in response to activation of distinct AMPK signaling pathways
    Ming Jing
    Dept of Medicine, Case Western Reserve Univ, 10900 Euclid Ave, Cleveland, OH 44106 4951, USA
    Am J Physiol Cell Physiol 295:C1071-82. 2008
    ..We conclude that although azide, hypoxia, and AICAR all activate AMPK, the downstream signaling pathways are distinct, with azide and hypoxia stimulating ERK1/2 and AICAR stimulating the p38 pathway...
  63. pmc AMP-activated protein kinase alpha2 deficiency affects cardiac cardiolipin homeostasis and mitochondrial function
    Yoni Athea
    INSERM U 769, Universite Paris Sud 11, 5 rue J6B Clément, F 92296 Chatenay Malabry, France
    Diabetes 56:786-94. 2007
    ..Here, we investigated whether deletion of AMPKalpha2, the main cardiac catalytic isoform, alters mitochondrial function and biogenesis...
  64. ncbi Estradiol-mediated endothelial nitric oxide synthase association with heat shock protein 90 requires adenosine monophosphate-dependent protein kinase
    Eberhard Schulz
    Evans Memorial Department of Medicine, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Mass 02118, USA
    Circulation 111:3473-80. 2005
    ..We therefore investigated whether AMPK is activated by estradiol in endothelial cells and plays a role in estradiol-induced eNOS activation...
  65. pmc Dissociation of AMP-activated protein kinase and p38 mitogen-activated protein kinase signaling in skeletal muscle
    Richard C Ho
    Research Division, Joslin Diabetes Center, Boston, MA 02215, USA
    Biochem Biophys Res Commun 362:354-9. 2007
    ..Next, we used transgenic mice expressing an inactive form of the AMPKalpha2 catalytic subunit in skeletal muscle (AMPKalpha2i TG mice)...
  66. pmc Ablation of AMP-activated protein kinase alpha2 activity exacerbates insulin resistance induced by high-fat feeding of mice
    Nobuharu Fujii
    Department of Medicine, Research Division, Joslin Diabetes Center, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 57:2958-66. 2008
    ..We determined whether muscle AMP-activated protein kinase (AMPK) has a role in the development of insulin resistance...
  67. pmc Resveratrol inhibits cardiac hypertrophy via AMP-activated protein kinase and Akt
    Anita Y M Chan
    Cardiovascular Research Group and the Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada
    J Biol Chem 283:24194-201. 2008
    ..Taken together, our data suggest that resveratrol exerts anti-hypertrophic effects by activating AMPK via LKB1 and inhibiting Akt, thus suppressing protein synthesis and gene transcription...
  68. doi Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice
    Xu Huang
    MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    Biochem J 412:211-21. 2008
    ....
  69. doi AMP-activated protein kinase regulates lymphocyte responses to metabolic stress but is largely dispensable for immune cell development and function
    Alice Mayer
    Laboratoire de Physiologie Animale, Universite Libre de Bruxelles, Gosselies, Belgium
    Eur J Immunol 38:948-56. 2008
    ..In conclusion, AMPK represents an important enzyme allowing lymphocytes to resist a mild energy crisis in vitro, but is largely dispensable for activation and expression of effector function in response to antigen stimulation...
  70. doi Role of AMP-activated protein kinase in autophagy and proteasome function
    Rosa Viana
    Instituto de Biomedicina de Valencia, CSIC, Nutrient signaling, Jaime Roig 11, 46010 Valencia, Spain Centre for Biomedical Research on Rare Diseases CIBERER, Valencia, Spain
    Biochem Biophys Res Commun 369:964-8. 2008
    ..On the other hand, AICAR inhibits the proteasomal degradation of proteins by an AMPK-dependent mechanism. This is a novel function of AMPK that allows the regulation of proteasomal activity under conditions of energy demand...
  71. doi Identification of protein kinase D as a novel contraction-activated kinase linked to GLUT4-mediated glucose uptake, independent of AMPK
    Joost J F P Luiken
    Department of Molecular Genetics, Cardiovascular Research Institute Maastricht CARIM, Maastricht University, Maastricht, The Netherlands
    Cell Signal 20:543-56. 2008
    ..activated under these same conditions, in vitro phosphorylation assays and studies with cardiac myocytes from AMPKalpha2(-/-) mice indicated that activation of PKD occurs independent of AMPK activation...
  72. ncbi Increased glucose disposal and AMP-dependent kinase signaling in a mouse model of hemochromatosis
    Jingyu Huang
    Department of Biochemistry, The University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    J Biol Chem 282:37501-7. 2007
    ..Instead, the Hfe(-/-) mice demonstrate increased adiponectin levels and activation of AMP-dependent kinase...
  73. ncbi Dual cardiac contractile effects of the alpha2-AMPK deletion in low-flow ischemia and reperfusion
    Karla Carvajal
    INSERM U 769, Faculte de Pharmacie, Universite Paris Sud, Chatenay Malabry, France
    Am J Physiol Heart Circ Physiol 292:H3136-47. 2007
    ..In conclusion, alpha(2)-AMPK is required for a normal glucose uptake and glycogen content, which protects the heart from the development of the ischemic contracture, but not for contractile recovery in the absence of fatty acids...
  74. ncbi Role of AMPKalpha2 in basal, training-, and AICAR-induced GLUT4, hexokinase II, and mitochondrial protein expression in mouse muscle
    Sebastian B Jørgensen
    Dept of Human Physiology, Copenhagen Muscle Research Centre, Inst of Exercise and Sport Sciences, 13 Universitetsparken, Univ of Copenhagen, DK 2100 Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 292:E331-9. 2007
    ..In both muscle types, AMPKalpha2 activity was increased in response to both stimuli, whereas AMPKalpha1 activity was increased only in response ..
  75. pmc Neuroprotective effects of adenosine monophosphate-activated protein kinase inhibition and gene deletion in stroke
    Jun Li
    Department of Neurology, University of Connecticut Health Center, Farmington, CT 06030, USA
    Stroke 38:2992-9. 2007
    ..In this study, we examined the effects of AMPK inhibition using both pharmacological and genetic approaches in an in vivo stroke model...
  76. ncbi Plectin scaffolds recruit energy-controlling AMP-activated protein kinase (AMPK) in differentiated myofibres
    Martin Gregor
    Department of Molecular Cell Biology, Max F Perutz Laboratories, University of Vienna, A 1030 Vienna, Austria
    J Cell Sci 119:1864-75. 2006
    ..The distinct plectin expression patterns in different fibre types combined with its involvement in the regulation of isoform compositions of AMPK complexes could provide a mechanism whereby cytoarchitecture influences energy homeostasis...
  77. ncbi Lack of AMPKalpha2 enhances pyruvate dehydrogenase activity during exercise
    Ditte K Klein
    Copenhagen Muscle Research Centre, Section of Human Physiology, Department of Exercise and Sport Sciences, University of Copenhagen, 13, Universitetsparken, 2100, Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 293:E1242-9. 2007
    ..01) and increased AMPKalpha2 activity in wild-type (WT) mice (110%, P < 0...
  78. ncbi Glucose metabolism and energy homeostasis in mouse hearts overexpressing dominant negative alpha2 subunit of AMP-activated protein kinase
    Yanqiu Xing
    Nuclear Magnetic Resonance Laboratory for Physiological Chemistry, Cardiovascular Division and Research Division, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 278:28372-7. 2003
    ..Thus, AMPK alpha2 is necessary for maintaining myocardial energy homeostasis during ischemia. It is likely that the functional role of AMPK in myocardial energy metabolism resides both in energy supply and utilization...
  79. doi The alpha-subunit of AMPK is essential for submaximal contraction-mediated glucose transport in skeletal muscle in vitro
    Natalie Lefort
    Department of Anatomy, Laval University Hospital Research Center, Quebec, Canada
    Am J Physiol Endocrinol Metab 295:E1447-54. 2008
    ..These data demonstrate that AMPK activation is essential for both AICAR and submaximal contraction-induced glucose transport in skeletal muscle but that AMPK-independent mechanisms are also involved...
  80. ncbi Functional role of AMP-activated protein kinase in the heart during exercise
    Nicolas Musi
    Research Division, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
    FEBS Lett 579:2045-50. 2005
    ..these increases by studying transgenic (TG) mice expressing a cardiac-specific dominant-negative (inactivating) AMPKalpha2 subunit. Exercise increased cardiac AMPKalpha2 activity in the wild type mice but not in TG...
  81. ncbi Inhibition of AMP-activated protein kinase protects pancreatic beta-cells from cytokine-mediated apoptosis and CD8+ T-cell-induced cytotoxicity
    Audrey Riboulet-Chavey
    Professor and Head of Department of Cell Biology, Division of Medicine, Sir Alexander Fleming Building, Imperial College, London, Exhibition Road, London SW7 2AZ, UK
    Diabetes 57:415-23. 2008
    ..Here, we examine the importance of beta-cell AMPK in cytokine-induced apoptosis and in the cytotoxic action of CD8(+) T-cells...
  82. ncbi Skeletal muscle adaptation to exercise training: AMP-activated protein kinase mediates muscle fiber type shift
    Katja S C Röckl
    Research Division, Joslin Diabetes Center and Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts 02215, USA
    Diabetes 56:2062-9. 2007
    ..this training-induced shift was reduced by approximately 40% in transgenic mice expressing a muscle-specific AMPKalpha2 inactive subunit. Sedentary mice carrying an AMPK-activating mutation (gamma1TG) showed a 2...
  83. pmc Activation of AMP kinase alpha1 subunit induces aortic vasorelaxation in mice
    Françoise Goirand
    Universite Paris Sud, IFR 141, Chatenay Malabry, France
    J Physiol 581:1163-71. 2007
    ..aorta were isolated from C57Bl6 mice and mice deficient in the AMPK catalytic alpha1 (AMPKalpha1-/-) or alpha2 (AMPKalpha2-/-) subunit and their littermate controls, and mounted in an organ bath...
  84. ncbi Cardioprotective effects of short-term caloric restriction are mediated by adiponectin via activation of AMP-activated protein kinase
    Ken Shinmura
    Division of Geriatric Medicine, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo, Japan 160 8582
    Circulation 116:2809-17. 2007
    ..We have demonstrated that short-term CR improves myocardial ischemic tolerance and increases adiponectin levels. Here, we investigated the specific role of adiponectin in CR-induced cardioprotection...
  85. pmc AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation
    Haihong Zong
    Howard Hughes Medical Institute and the Departments of Internal Medicine, Cell Biology, and Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 99:15983-7. 2002
    ..These data demonstrate that by sensing the energy status of the muscle cell, AMPK is a critical regulator involved in initiating mitochondrial biogenesis...
  86. pmc AMP-activated protein kinase mediates preconditioning in cardiomyocytes by regulating activity and trafficking of sarcolemmal ATP-sensitive K(+) channels
    Andrey Sukhodub
    Maternal and Child Health Sciences, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK
    J Cell Physiol 210:224-36. 2007
    ....
  87. ncbi Role of the alpha2-isoform of AMP-activated protein kinase in the metabolic response of the heart to no-flow ischemia
    Elham Zarrinpashneh
    Division of Cardiology, Universite Catholique de Louvain, B 1200 Brussels, Belgium
    Am J Physiol Heart Circ Physiol 291:H2875-83. 2006
    ..In conclusion, AMPKalpha(2) is required for the metabolic response of the heart to no-flow ischemia. The remaining AMPKalpha(1) cannot compensate for the absence of AMPKalpha(2)...
  88. ncbi Cellular distribution and developmental expression of AMP-activated protein kinase isoforms in mouse central nervous system
    A M Turnley
    The Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    J Neurochem 72:1707-16. 1999
    ....
  89. ncbi The relationship between p38 mitogen-activated protein kinase and AMP-activated protein kinase during myocardial ischemia
    Sebastien Jacquet
    Cardiovascular Division, King s College London, St Thomas Hospital, London SEI 7EH, UK
    Cardiovasc Res 76:465-72. 2007
    ..We therefore examined whether AMPK may be the principal "ischemia sensor" responsible for p38 MAPK activation during myocardial ischemia...
  90. ncbi Glucose recruits K(ATP) channels via non-insulin-containing dense-core granules
    Shao Nian Yang
    The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Cell Metab 6:217-28. 2007
    ..Our data suggest that glucose can recruit K(ATP) channels to the beta cell plasma membrane via non-insulin-containing dense-core granules in a Ca(2+)- and PKA-dependent manner...
  91. pmc AMP activated protein kinase-alpha2 deficiency exacerbates pressure-overload-induced left ventricular hypertrophy and dysfunction in mice
    Ping Zhang
    Cardiovascular Division, University of Minnesota, Minneapolis, MN 55455, USA
    Hypertension 52:918-24. 2008
    ..To test the hypothesis that AMPKalpha2 protects the heart against systolic overload-induced ventricular hypertrophy and dysfunction, we studied the ..
  92. doi Role of adenosine 5'-monophosphate-activated protein kinase in interleukin-6 release from isolated mouse skeletal muscle
    Stephan Glund
    Department of Molecular Medicine and Surgery, Section for Integrative Physiology, Karolinska Institutet, Stockholm, Sweden
    Endocrinology 150:600-6. 2009
    ..Skeletal muscle from AMPKalpha2 kinase-dead transgenic, AMPKalpha1 knockout (KO) and AMPKgamma3 KO mice and respective wild-type littermates was ..
  93. pmc AMPK-independent pathways regulate skeletal muscle fatty acid oxidation
    Nicolas Dzamko
    St Vincent s Institute, 9 Princes Street, Fitzroy, Victoria 3065, Australia
    J Physiol 586:5819-31. 2008
    ..These data demonstrate that AMPK is not essential for the regulation of fatty acid oxidation by AICAR or muscle contraction...
  94. pmc AMPK regulates basal skeletal muscle capillarization and VEGF expression, but is not necessary for the angiogenic response to exercise
    Kevin A Zwetsloot
    Department of Exercise and Sport Science, East Carolina University, Greenville, NC 27858, USA
    J Physiol 586:6021-35. 2008
    ....
  95. doi Crucial role for LKB1 to AMPKalpha2 axis in the regulation of CD36-mediated long-chain fatty acid uptake into cardiomyocytes
    Daphna D J Habets
    Department of Molecular Genetics, Cardiovascular Research Institute Maastricht, Maastricht University, 6200 MD Maastricht, The Netherlands
    Biochim Biophys Acta 1791:212-9. 2009
    ..However, which catalytic isoform (AMPKalpha1 versus AMPKalpha2) is involved, is unknown...
  96. pmc AMP-activated protein kinase deficiency enhances myocardial ischemia/reperfusion injury but has minimal effect on the antioxidant/antinitrative protection of adiponectin
    Yajing Wang
    Department of Emergency Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Circulation 119:835-44. 2009
    ..Deficiency of both AMP-activated protein kinase (AMPK) and adiponectin occurs in diabetes, but whether AMPK is cardioprotective or a central mediator of adiponectin cardioprotection in vivo remains unknown...
  97. pmc AMP-activated protein kinase phosphorylates retinoblastoma protein to control mammalian brain development
    Biplab Dasgupta
    Department of Pathology, Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, MO 63110, USA
    Dev Cell 16:256-70. 2009
    ..The AMPK-Rb axis is utilized by both growth factors and energy restriction to increase NPC growth. Our results reveal that AMPK integrates growth factor signaling with cell cycle control to regulate brain development...
  98. doi AMPKalpha2 counteracts the development of cardiac hypertrophy induced by isoproterenol
    Elham Zarrinpashneh
    Universite Catholique de Louvain, Division of Cardiology, 55 Avenue Hippocrate, CARD5550, B 1200 Brussels, Belgium
    Biochem Biophys Res Commun 376:677-81. 2008
    ..However, there is no genetic evidence to confirm this hypothesis. We investigated the contribution of AMPKalpha2 in the control of cardiac hypertrophy by using AMPKalpha2-/- mice submitted to isoproterenol...
  99. pmc Loss of AMPK exacerbates experimental autoimmune encephalomyelitis disease severity
    Narender Nath
    Department of Pediatrics, Medical University of South Carolina, SC 29425, USA
    Biochem Biophys Res Commun 386:16-20. 2009
    ..exhibited severe EAE disease with profound infiltration of mononuclear cells compared to wild type mice however, AMPKalpha2 is not involved in enhancing the severity of the disease...
  100. pmc Genetic disruption of AMPK signaling abolishes both contraction- and insulin-stimulated TBC1D1 phosphorylation and 14-3-3 binding in mouse skeletal muscle
    Christian Pehmøller
    Molecular Physiology Group, Copenhagen Muscle Research Centre, Dept of Exercise and Sport Sciences, Univ of Copenhagen, DK 2100, Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 297:E665-75. 2009
    ..Thus, TBC1D1 is differentially regulated in response to insulin and contraction. This study provides genetic evidence to support an important role for AMPK in regulating TBC1D1 in response to both of these physiological stimuli...
  101. pmc Endogenous peroxisome proliferator-activated receptor-gamma augments fatty acid uptake in oxidative muscle
    Andrew W Norris
    Department of Pediatrics, University of Iowa, Iowa City, Iowa 52242, USA
    Endocrinology 149:5374-83. 2008
    ..Thus, when PPARgamma activity in muscle is absent or reduced, there will be decreased fatty acid disposal leading to diminished energy utilization and ultimately adiposity...

Research Grants26

  1. THE c-jun PROTO-ONCOGENE AND TUMOR HYPOXIA
    Keith Laderoute; Fiscal Year: 2005
    ..They will also identify new mammalian transcriptional regulators responsive to a wide range of low oxygen conditions. ..
  2. Role of LKB1 and AMPK in Metformin and TZD Control of Glucose Metabolism in Liver
    REUBEN SHAW; Fiscal Year: 2007
    ..These studies will better illuminate the mechanism of action of these two widely used type 2 diabetes modalities, as well as identifying many new targets for the development of future therapeutics. ..
  3. Muscle PPARgamma and Metabolic Regulation
    Andrew Norris; Fiscal Year: 2007
    ..abstract_text> ..
  4. HYPOXIC STRESS MECHANISMS IN RADIATION AND CHEMOTHERAPY
    Keith Laderoute; Fiscal Year: 2009
    ..An understanding of these MTF-1-dependent properties should aid in the development of novel prognostic and new modalities for neoplastic diseases. ..
  5. Regulatory Control of Metabolic Flexibility in Skeletal Muscle.
    Andrew Norris; Fiscal Year: 2009
    ..The knowledge gained from the successful completion of this project will help design new strategies to prevent and treat type 2 diabetes onset and progression. ..
  6. ROLE OF AMPK IN TUMOR DEVELOPMENT AND THERAPY
    Keith R Laderoute; Fiscal Year: 2010
    ..Ultimately, we intend to determine whether the AMPK "emergency stress response" can be exploited for the therapy or prognosis of human cancer. ..
  7. Role of LKB1 and AMPK in Metformin and TZD Control of Glucose Metabolism in Liver
    REUBEN JAMES SHAW; Fiscal Year: 2010
    ..These studies will better illuminate the mechanism of action of these two widely used type 2 diabetes modalities, as well as identifying many new targets for the development of future therapeutics. ..
  8. ROLE OF AMPK IN TUMOR DEVELOPMENT AND THERAPY
    Keith Laderoute; Fiscal Year: 2007
    ..Ultimately, we intend to determine whether the AMPK "emergency stress response" can be exploited for the therapy or prognosis of human cancer. ..
  9. Regulation of Mammalian Oocyte Maturation
    Stephen Downs; Fiscal Year: 2007
    ..Furthermore, these studies will benefit the development of in vitro systems where either meiotic arrest or completion of meiotic maturation is the desired endpoint. ..
  10. TUMOR HYPOXIA AND C JUN PROTOONCOGENE EXPRESSION
    Keith Laderoute; Fiscal Year: 2000
    ..Genes such as these regulated by the c- jun/AP1 complexes may be part of a concerted response to injury or environmental stress associated with perturbations of cellular redox states. ..
  11. FORMAL METHODS APPLIED TO BIOLOGICAL SIGNALING NETWORKS
    Keith Laderoute; Fiscal Year: 2006
    ..abstract_text> ..
  12. Regulatory Control of Metabolic Flexibility in Skeletal Muscle.
    Andrew W Norris; Fiscal Year: 2010
    ..The knowledge gained from the successful completion of this project will help design new strategies to prevent and treat type 2 diabetes onset and progression. ..