Gene Symbol: Prickle1
Description: prickle planar cell polarity protein 1
Alias: 1110058P22Rik, AW215793, Prickle, b2b019Clo, mpk1, prickle-like protein 1, prickle homolog 1, prickle like 1
Species: mouse
Products:     Prickle1

Top Publications

  1. Vladar E, Bayly R, Sangoram A, Scott M, Axelrod J. Microtubules enable the planar cell polarity of airway cilia. Curr Biol. 2012;22:2203-12 pubmed publisher
  2. Okuda H, Miyata S, Mori Y, Tohyama M. Mouse Prickle1 and Prickle2 are expressed in postmitotic neurons and promote neurite outgrowth. FEBS Lett. 2007;581:4754-60 pubmed
    ..However, the functional role of prickle in the brain in particular is not known. We first indicated that mouse Prickle1 and Prickle2 are continually expressed in the brain throughout the embryonic stages and are observed to be ..
  3. Bassuk A, Wallace R, Buhr A, Buller A, Afawi Z, Shimojo M, et al. A homozygous mutation in human PRICKLE1 causes an autosomal-recessive progressive myoclonus epilepsy-ataxia syndrome. Am J Hum Genet. 2008;83:572-81 pubmed publisher
    ..This report identifies a mutation in PRICKLE1 (also known as RILP for REST/NRSF interacting LIM domain protein) in all three of these pedigrees...
  4. Tao H, Manak J, Sowers L, Mei X, Kiyonari H, Abe T, et al. Mutations in prickle orthologs cause seizures in flies, mice, and humans. Am J Hum Genet. 2011;88:138-49 pubmed publisher
    ..We identified human epilepsy patients with heterozygous mutations in either PRICKLE1 or PRICKLE2. In overexpression assays in zebrafish, prickle mutations resulted in aberrant prickle function...
  5. Liu C, Lin C, Whitaker D, Bakeri H, Bulgakov O, Liu P, et al. Prickle1 is expressed in distinct cell populations of the central nervous system and contributes to neuronal morphogenesis. Hum Mol Genet. 2013;22:2234-46 pubmed publisher
    ..For example, a missense mutation in Prickle 1 (Pk1) is associated with progressive myoclonus epilepsy (PME) in humans, and its reduced gene dosage increases ..
  6. Tao H, Inoue K, Kiyonari H, Bassuk A, Axelrod J, Sasaki H, et al. Nuclear localization of Prickle2 is required to establish cell polarity during early mouse embryogenesis. Dev Biol. 2012;364:138-48 pubmed publisher
    ..However, the mechanism of TE formation is currently not well understood. Prickle1 (Pk1), a core component of the planar cell polarity (PCP) pathway, is essential for epiblast polarization before ..
  7. Fujimura L, Hatano M. Role of Prickle1 and Prickle2 in neurite outgrowth in murine neuroblastoma cells. Methods Mol Biol. 2012;839:173-85 pubmed publisher
    Murine Prickle2 but not Prickle1 gene expression was induced in C1300 neuroblastoma cell line during neurite-like process formation induced by all trans-retinoic acid (RA)...
  8. Narimatsu M, Bose R, Pye M, Zhang L, Miller B, Ching P, et al. Regulation of planar cell polarity by Smurf ubiquitin ligases. Cell. 2009;137:295-307 pubmed publisher
    ..Further, we show that Smurfs engage in a noncanonical Wnt signaling pathway that targets the core PCP protein Prickle1 for ubiquitin-mediated degradation...
  9. Tao H, Suzuki M, Kiyonari H, Abe T, Sasaoka T, Ueno N. Mouse prickle1, the homolog of a PCP gene, is essential for epiblast apical-basal polarity. Proc Natl Acad Sci U S A. 2009;106:14426-31 pubmed publisher
    ..We focused on Prickle, one of the core components of the PCP pathway, and deleted one of two mouse prickle homologous genes, mpk1...

More Information


  1. Song M, Shirasaki R, Cai C, Ruiz E, Evans S, Lee S, et al. T-Box transcription factor Tbx20 regulates a genetic program for cranial motor neuron cell body migration. Development. 2006;133:4945-55 pubmed
    ..the coordinate downregulation of multiple components of the planar cell polarity pathway including Fzd7, Wnt11, Prickle1, Vang1 and Vang2...
  2. Minegishi K, Hashimoto M, Ajima R, Takaoka K, Shinohara K, Ikawa Y, et al. A Wnt5 Activity Asymmetry and Intercellular Signaling via PCP Proteins Polarize Node Cells for Left-Right Symmetry Breaking. Dev Cell. 2017;40:439-452.e4 pubmed publisher
    ..The absence of planar cell polarity (PCP) core proteins Prickle1 and Prickle2 in individual cells or local forced expression of Wnt5a perturbed polarization of neighboring wild-..
  3. Yang T, Bassuk A, Fritzsch B. Prickle1 stunts limb growth through alteration of cell polarity and gene expression. Dev Dyn. 2013;242:1293-306 pubmed publisher
    ..Based on the interaction between Van Gogh and Prickle in Drosophila, we hypothesized the vertebrate Prickle1 has a similar function as Vangl2 in limb development...
  4. Fujimura L, Watanabe Takano H, Sato Y, Tokuhisa T, Hatano M. Prickle promotes neurite outgrowth via the Dishevelled dependent pathway in C1300 cells. Neurosci Lett. 2009;467:6-10 pubmed publisher
    Murine Prickle1 and Prickle2 belong to the planar cell polarity genes. Prickle2 but not Prickle1 gene expression was induced in C1300 neuroblastoma cells during neurite-like process formation induced by retinoic acid (RA)...
  5. Nagy I, Xu Q, Naillat F, Ali N, Miinalainen I, Samoylenko A, et al. Impairment of Wnt11 function leads to kidney tubular abnormalities and secondary glomerular cystogenesis. BMC Dev Biol. 2016;16:30 pubmed publisher
    ..The C57Bl6 Wnt11 (-/-) mouse generated here provides a model for studying the mechanisms behind tubular anomalies and glomerular cyst formation. ..
  6. GARCIA GARCIA M, Shibata M, Anderson K. Chato, a KRAB zinc-finger protein, regulates convergent extension in the mouse embryo. Development. 2008;135:3053-62 pubmed publisher
  7. Liu C, Lin C, Gao C, May Simera H, Swaroop A, Li T. Null and hypomorph Prickle1 alleles in mice phenocopy human Robinow syndrome and disrupt signaling downstream of Wnt5a. Biol Open. 2014;3:861-70 pubmed publisher
    ..We recently demonstrated a role of Prickle1, a core PCP molecule in Drosophila, in mammalian neuronal development...
  8. Yang T, Jia Z, Bryant Pike W, Chandrasekhar A, Murray J, Fritzsch B, et al. Analysis of PRICKLE1 in human cleft palate and mouse development demonstrates rare and common variants involved in human malformations. Mol Genet Genomic Med. 2014;2:138-51 pubmed publisher
    ..We recently showed the noncanonical Wnt/planar cell polarity (PCP) signaling molecule Prickle1 (Prickle like 1) also stunts limb growth in mice...
  9. Yang T, Bassuk A, Stricker S, Fritzsch B. Prickle1 is necessary for the caudal migration of murine facial branchiomotor neurons. Cell Tissue Res. 2014;357:549-61 pubmed publisher
    ..Zebrafish prickle1a (prickle-like 1a) and prickle1b, two orthologs of Prickle1, act non-cell-autonomously and cell-autonomously, respectively, to regulate FBM migration...
  10. Kuss P, Kraft K, Stumm J, Ibrahim D, Vallecillo GarcĂ­a P, Mundlos S, et al. Regulation of cell polarity in the cartilage growth plate and perichondrium of metacarpal elements by HOXD13 and WNT5A. Dev Biol. 2014;385:83-93 pubmed publisher
    ..Concomitant we observed mislocalization of core planar cell polarity (PCP) components DVL2 and PRICKLE1 in spdh metacarpals indicating a defect in the WNT/PCP pathway...
  11. Dawe C, Kooistra M, Fairbridge N, Pisio A, McDermid H. Role of chromatin remodeling gene Cecr2 in neurulation and inner ear development. Dev Dyn. 2011;240:372-83 pubmed publisher
    ..The mechanism of Cecr2 action in neurogenesis and inner ear development is likely complex. ..
  12. Deans M, Antic D, Suyama K, Scott M, Axelrod J, Goodrich L. Asymmetric distribution of prickle-like 2 reveals an early underlying polarization of vestibular sensory epithelia in the inner ear. J Neurosci. 2007;27:3139-47 pubmed
    ..We report that the putative PCP protein Prickle-like 2 (Pk2) is distributed in crescents on the medial sides of vestibular epithelial cells before the ..
  13. Lim B, Matsumoto S, Yamamoto H, Mizuno H, Kikuta J, Ishii M, et al. Prickle1 promotes focal adhesion disassembly in cooperation with the CLASP-LL5? complex in migrating cells. J Cell Sci. 2016;129:3115-29 pubmed publisher
    ..Here, we show that Prickle1 regulates front-rear polarization and migration of gastric cancer MKN1 cells...
  14. Gibbs B, Damerla R, Vladar E, Chatterjee B, Wan Y, Liu X, et al. Prickle1 mutation causes planar cell polarity and directional cell migration defects associated with cardiac outflow tract anomalies and other structural birth defects. Biol Open. 2016;5:323-35 pubmed publisher
    ..Here, we show that mutant mice harboring a newly described mutation termed Beetlejuice (Bj) in Prickle1 (Pk1), a PCP component, exhibit developmental phenotypes involving cell polarity defects, including skeletal, ..
  15. Shimojo M. RE1-silencing transcription factor (REST) and REST-interacting LIM domain protein (RILP) affect P19CL6 differentiation. Genes Cells. 2011;16:90-100 pubmed publisher
    ..These results suggest that RILP expression and function control REST action more so than does REST expression and is an important regulatory role in cardiomyocyte differentiation. ..
  16. Crompton L, Du Roure C, Rodriguez T. Early embryonic expression patterns of the mouse Flamingo and Prickle orthologues. Dev Dyn. 2007;236:3137-43 pubmed
    ..Here, we show that the murine Flamingo orthologues Celsr1-3 and the Prickle orthologues Prickle1, Prickle2, and Testin have dynamic patterns of expression during pregastrulation and gastrulation stages...
  17. Bekman E, Henrique D. Embryonic expression of three mouse genes with homology to the Drosophila melanogaster prickle gene. Mech Dev. 2002;119 Suppl 1:S77-81 pubmed
    The Drosophila melanogaster gene prickle-spiny-legs (pk) functions in an intercellular feedback loop that is central to the establishment of planar cell polarity in the eye and epidermis of the fly, by modulating Frizzled-Disheveled ..
  18. Yang T, Kersigo J, Wu S, Fritzsch B, Bassuk A. Prickle1 regulates neurite outgrowth of apical spiral ganglion neurons but not hair cell polarity in the murine cochlea. PLoS ONE. 2017;12:e0183773 pubmed publisher
    ..b>Prickle1 is a PCP signaling gene that belongs to the prickle / espinas / testin family...
  19. Paemka L, Mahajan V, Skeie J, Sowers L, Ehaideb S, Gonzalez Alegre P, et al. PRICKLE1 interaction with SYNAPSIN I reveals a role in autism spectrum disorders. PLoS ONE. 2013;8:e80737 pubmed publisher
    ..Recently, PRICKLE1 missense mutations were found to segregate with ASD...
  20. Hoffman J, Wu C, Merrill B. Tcf7l1 prepares epiblast cells in the gastrulating mouse embryo for lineage specification. Development. 2013;140:1665-75 pubmed publisher
    ..We suggest that the role of Tcf7l1 in mammals is to inhibit the GRN to ensure the coordination of lineage specification with the dynamic cellular events occurring during gastrulation. ..
  21. Shafer B, Onishi K, Lo C, Colakoglu G, Zou Y. Vangl2 promotes Wnt/planar cell polarity-like signaling by antagonizing Dvl1-mediated feedback inhibition in growth cone guidance. Dev Cell. 2011;20:177-91 pubmed publisher
  22. Babayeva S, Zilber Y, Torban E. Planar cell polarity pathway regulates actin rearrangement, cell shape, motility, and nephrin distribution in podocytes. Am J Physiol Renal Physiol. 2011;300:F549-60 pubmed publisher
    ..Our observations indicate that PCP signaling may play an important role both in podocyte development and FP cytoskeleton dynamics. ..
  23. Tissir F, Goffinet A. Expression of planar cell polarity genes during development of the mouse CNS. Eur J Neurosci. 2006;23:597-607 pubmed
    ..Fzd3 with that of dishevelled 1, 2 and 3 (Dvl1-3), van gogh-like 1 and 2 (Vangl1, 2), and prickle-like 1 and 2 (Prickle1, 2), during mouse CNS development, from embryonic day 10.5 to postnatal day 21...
  24. Glasco D, Sittaramane V, Bryant W, Fritzsch B, Sawant A, Paudyal A, et al. The mouse Wnt/PCP protein Vangl2 is necessary for migration of facial branchiomotor neurons, and functions independently of Dishevelled. Dev Biol. 2012;369:211-22 pubmed publisher
    ..Interestingly, genetic-interaction experiments suggest that rostral FBM neuron migration, which is normally suppressed, depends upon Dvl function. ..