Genomes and Genes
Gene Symbol: Prex2
Description: phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
Alias: 6230420N16Rik, AI316880, AI553603, C030045D06Rik, D430013K02, Depdc2, P-Rex2, phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein, DEP domain containing 2, DEP domain-containing protein 2, ptdIns(3,4,5)-dependent Rac exchanger 2
- Li C, Yen C, Chen Y, Lee K, Fang C, Zhang X, et al. Characterization of the GNMT-HectH9-PREX2 tripartite relationship in the pathogenesis of hepatocellular carcinoma. Int J Cancer. 2017;140:2284-2297 pubmed publisher..We identified PREX2, a novel PTEN inhibitor, as a GNMT-interacting protein...
- Lawson C, Donald S, Anderson K, Patton D, Welch H. P-Rex1 and Vav1 cooperate in the regulation of formyl-methionyl-leucyl-phenylalanine-dependent neutrophil responses. J Immunol. 2011;186:1467-76 pubmed publisher..We conclude that P-Rex1 and Vav1 together are the major fMLFR-dependent Dbl family Rac-GEFs in neutrophils and cooperate in the control of fMLF-stimulated neutrophil responses. ..
- Hodakoski C, Hopkins B, Barrows D, Mense S, Keniry M, Anderson K, et al. Regulation of PTEN inhibition by the pleckstrin homology domain of P-REX2 during insulin signaling and glucose homeostasis. Proc Natl Acad Sci U S A. 2014;111:155-60 pubmed publisher..Consistent with its function as a PTEN inhibitor, deletion of Prex2 in fibroblasts and mice results in increased Pten activity and decreased insulin signaling in liver and adipose ..
- Lissanu Deribe Y. Interplay between PREX2 mutations and the PI3K pathway and its effect on epigenetic regulation of gene expression in NRAS-mutant melanoma. Small Gtpases. 2016;7:178-85 pubmed publisherb>PREX2 is a PTEN interacting protein that is significantly mutated in melanoma and pancreatic ductal adenocarcinoma. Recently, we reported the mechanistic basis of melanomagenesis by PREX2 mutations...