Prdx6

Summary

Gene Symbol: Prdx6
Description: peroxiredoxin 6
Alias: 1-Cys Prx, 1-cysPrx, 9430088D19Rik, AA690119, Aop2, Brp-12, CP-3, GPx, Ltw-4, Ltw4, Lvtw-4, NSGPx, ORF06, Prdx5, aiPLA2, peroxiredoxin-6, 1-Cys peroxiredoxin, acidic calcium-independent phospholipase A2, anti-oxidant protein 2, related sequence 3, antioxidant protein 2, non-selenium glutathione peroxidase, peroxiredoxin 5, related sequence 3, peroxiredoxin 6, related sequence 3
Species: mouse
Products:     Prdx6

Top Publications

  1. Lee T, Yu S, Kim S, Kim Y, Choi I, Kang S, et al. Characterization of the murine gene encoding 1-Cys peroxiredoxin and identification of highly homologous genes. Gene. 1999;234:337-44 pubmed
    ..These results suggest that only the 1-Cys Prx gene might be relevant for studying the function of the 1-Cys Prx in the murine system. ..
  2. Prows D, Hafertepen A, Winterberg A, Gibbons W, Liu C, Nick T. Genetic analysis of hyperoxic acute lung injury survival in reciprocal intercross mice. Physiol Genomics. 2007;30:271-81 pubmed
    ..QTL results confirmed that both parental strains contribute dominant resistance alleles to their offspring to determine individual HALI susceptibility. ..
  3. Gallagher B, Phelan S. Investigating transcriptional regulation of Prdx6 in mouse liver cells. Free Radic Biol Med. 2007;42:1270-7 pubmed
    b>Prdx6, a unique member of the peroxiredoxin family of antioxidants, is highly expressed in liver and protects cells from oxidative damage by reducing H2O2 and various lipid peroxides...
  4. ROEDE J, Stewart B, Petersen D. Decreased expression of peroxiredoxin 6 in a mouse model of ethanol consumption. Free Radic Biol Med. 2008;45:1551-8 pubmed publisher
    ..study were to investigate the effect of chronic ethanol treatment on inducing hepatic oxidative stress and peroxiredoxin 6 expression...
  5. Kümin A, Huber C, Rülicke T, Wolf E, Werner S. Peroxiredoxin 6 is a potent cytoprotective enzyme in the epidermis. Am J Pathol. 2006;169:1194-205 pubmed
    b>Peroxiredoxin 6 is an enzyme that detoxifies hydrogen peroxide and various organic peroxides...
  6. Eismann T, Huber N, Shin T, Kuboki S, Galloway E, Wyder M, et al. Peroxiredoxin-6 protects against mitochondrial dysfunction and liver injury during ischemia-reperfusion in mice. Am J Physiol Gastrointest Liver Physiol. 2009;296:G266-74 pubmed publisher
    ..One of these proteins, peroxiredoxin-6 (Prdx6), has never before been described in mitochondria...
  7. Mo Y, Feinstein S, Manevich Y, Zhang Q, Lu L, Ho Y, et al. 1-Cys peroxiredoxin knock-out mice express mRNA but not protein for a highly related intronless gene. FEBS Lett. 2003;555:192-8 pubmed
    ..Thus, mouse 1-cysPrx-P1 is an mRNA-expressed pseudogene that does not result in detectable protein in vivo. ..
  8. Wang X, Phelan S, Forsman Semb K, Taylor E, Petros C, Brown A, et al. Mice with targeted mutation of peroxiredoxin 6 develop normally but are susceptible to oxidative stress. J Biol Chem. 2003;278:25179-90 pubmed
    ..Peroxiredoxin 6 (PRDX6) (also called antioxidant protein 2, or AOP2) is a novel peroxiredoxin family member whose function in vivo is unknown...
  9. Munz B, Frank S, Hübner G, Olsen E, Werner S. A novel type of glutathione peroxidase: expression and regulation during wound repair. Biochem J. 1997;326 ( Pt 2):579-85 pubmed
    ..gene in human keratinocytes that encodes the human homologue of a bovine non-selenium glutathione peroxidase (GPx)...

More Information

Publications76

  1. Rolfs F, Huber M, Gruber F, Böhm F, Pfister H, Bochkov V, et al. Dual role of the antioxidant enzyme peroxiredoxin 6 in skin carcinogenesis. Cancer Res. 2013;73:3460-9 pubmed publisher
    The antioxidant enzyme peroxiredoxin 6 (Prdx6) is a key regulator of the cellular redox balance, particularly under stress conditions. We identified Prdx6 as an important player in different phases of skin carcinogenesis...
  2. Wang Y, Phelan S, Manevich Y, Feinstein S, Fisher A. Transgenic mice overexpressing peroxiredoxin 6 show increased resistance to lung injury in hyperoxia. Am J Respir Cell Mol Biol. 2006;34:481-6 pubmed
    b>Peroxiredoxin 6 (Prd x 6) is a novel peroxidase enzyme that is expressed at a high level in the lung...
  3. Kim D, Lee D, Jo M, Son D, Park M, Hwang C, et al. Exacerbation of collagen antibody-induced arthritis in transgenic mice overexpressing peroxiredoxin 6. Arthritis Rheumatol. 2015;67:3058-69 pubmed publisher
    b>Peroxiredoxin 6 plays important and complex roles in the process of inflammation, but its role in the development of rheumatoid arthritis (RA) remains unclear...
  4. Mohar I, Stamper B, Rademacher P, White C, Nelson S, Kavanagh T. Acetaminophen-induced liver damage in mice is associated with gender-specific adduction of peroxiredoxin-6. Redox Biol. 2014;2:377-87 pubmed publisher
    ..We conclude that adduction of peroxiredoxin-6 sensitizes male C57BL/6 mice to toxicity by acetaminophen. ..
  5. Paigen B, Mitchell D, Reue K, Morrow A, Lusis A, LeBoeuf R. Ath-1, a gene determining atherosclerosis susceptibility and high density lipoprotein levels in mice. Proc Natl Acad Sci U S A. 1987;84:3763-7 pubmed
    ..The human trait phenotypically resembles Ath-1 in the mouse. ..
  6. Fatma N, Singh P, Chhunchha B, Kubo E, Shinohara T, Bhargavan B, et al. Deficiency of Prdx6 in lens epithelial cells induces ER stress response-mediated impaired homeostasis and apoptosis. Am J Physiol Cell Physiol. 2011;301:C954-67 pubmed publisher
    The multifunctional cytoprotective protein peroxiredoxin 6 (Prdx6) maintains cellular homeostasis and membrane integrity by regulating expression of intracellular reactive oxygen species (ROS) and phospholipid turnover...
  7. Meruelo D, Rossomando A, Offer M, Buxbaum J, Pellicer A. Association of endogenous viral loci with genes encoding murine histocompatibility and lymphocyte differentiation antigens. Proc Natl Acad Sci U S A. 1983;80:5032-6 pubmed
  8. Xu X, Lu D, Zhuang R, Wei X, Xie H, Wang C, et al. The phospholipase A2 activity of peroxiredoxin 6 promotes cancer cell death induced by tumor necrosis factor alpha in hepatocellular carcinoma. Mol Carcinog. 2016;55:1299-308 pubmed publisher
    ..We identified eight differentially expressed proteins (>3-fold), including Peroxiredoxin 6 (PRDX6)...
  9. Walsh B, Pearl A, Suchy S, Tartaglio J, Visco K, Phelan S. Overexpression of Prdx6 and resistance to peroxide-induced death in Hepa1-6 cells: Prdx suppression increases apoptosis. Redox Rep. 2009;14:275-84 pubmed publisher
    ..b>Prdx6, a cytoplasmic protein elevated in certain cancers, is highly expressed in liver and transcriptionally regulated ..
  10. Phelan S, Beier D, Higgins D, Paigen B. Confirmation and high resolution mapping of an atherosclerosis susceptibility gene in mice on Chromosome 1. Mamm Genome. 2002;13:548-53 pubmed
    ..of potential candidate genes including the thiol-specific antioxidant gene Aop2, also known as peroxiredoxin 5 (Prdx5). AOP2 is capable of reducing hydroperoxides and lipid peroxides in the cell...
  11. Kümin A, Schafer M, Epp N, Bugnon P, Born Berclaz C, Oxenius A, et al. Peroxiredoxin 6 is required for blood vessel integrity in wounded skin. J Cell Biol. 2007;179:747-60 pubmed
    b>Peroxiredoxin 6 (Prdx6) is a cytoprotective enzyme with largely unknown in vivo functions. Here, we use Prdx6 knockout mice to determine its role in UV protection and wound healing...
  12. Erttmann S, Bast A, Seidel J, Breitbach K, Walther R, Steinmetz I. PGD2 and PGE2 regulate gene expression of Prx 6 in primary macrophages via Nrf2. Free Radic Biol Med. 2011;51:626-40 pubmed publisher
    b>Peroxiredoxin 6 (Prx 6) is a bifunctional enzyme with both glutathione peroxidase and acidic Ca(2+)-independent phospholipase A(2) activities...
  13. Pak J, Son W, Seo S, Hong S, Sohn W, Na B, et al. Peroxiredoxin 6 expression is inversely correlated with nuclear factor-?B activation during Clonorchis sinensis infestation. Free Radic Biol Med. 2016;99:273-285 pubmed publisher
    ..We examined the reciprocal regulation of two ESP-induced redox-active proteins, NF-?B and peroxiredoxin 6 (Prdx6), during C. sinensis infection...
  14. Wu Y, Manevich Y, Baldwin J, Dodia C, Yu K, Feinstein S, et al. Interaction of surfactant protein A with peroxiredoxin 6 regulates phospholipase A2 activity. J Biol Chem. 2006;281:7515-25 pubmed
    b>Peroxiredoxin 6 (Prdx6) is a "moonlighting" protein with both GSH peroxidase and phospholipase A(2) (PLA(2)) activities...
  15. Wang Y, Lu Q, Sheldon F, Ho Y, Phelan S, Beers M, et al. [Antioxidative role of peroxiredoxin 6 in acute lung injury]. Zhonghua Er Ke Za Zhi. 2008;46:739-44 pubmed
    To confirm the antioxidant protective effect of peroxiredoxin 6 (Prdx6) in acute lung injury in mice. Lung injury or lung alveolar type II epithelial cell (AEC II) injury models were induced in mice by 100% O2 exposure or H2O2 treatments...
  16. Tada N, Kimura S, Liu Lam Y, Hammerling U. Mouse alloantigen system Ly-m22 predominantly expressed on T lymphocytes and controlled by a gene linked to M1s region on chromosome 1. Hybridoma. 1983;2:29-38 pubmed
    ..Analysis of BXD and SWXL recombinant inbred strains revealed close linkage between Ly-m22 and Ltw-4 loci on chromosome 1. The estimated recombination frequency is 0.027 +/- 0.081. ..
  17. Strey C, Spellman D, Stieber A, Gonatas J, Wang X, Lambris J, et al. Dysregulation of stathmin, a microtubule-destabilizing protein, and up-regulation of Hsp25, Hsp27, and the antioxidant peroxiredoxin 6 in a mouse model of familial amyotrophic lateral sclerosis. Am J Pathol. 2004;165:1701-18 pubmed
    ..decrease of its most acidic and phosphorylated isoform, and up-regulation of heat shock proteins 25 and 27, peroxiredoxin 6, phosphatidylinositol transfer protein-alpha, apolipoprotein E, and ferritin heavy chain...
  18. Kubo E, Fatma N, Akagi Y, Beier D, Singh S, Singh D. TAT-mediated PRDX6 protein transduction protects against eye lens epithelial cell death and delays lens opacity. Am J Physiol Cell Physiol. 2008;294:C842-55 pubmed publisher
    ..b>Peroxiredoxin 6 (PRDX6), a protective molecule, regulates gene expression/function by controlling reactive oxygen species (..
  19. Abderrahim H, Jaramillo Babb V, Zhou Z, Vollrath D. Characterization of the murine TIGR/myocilin gene. Mamm Genome. 1998;9:673-5 pubmed
  20. Lusis A, Taylor B, Wangenstein R, LeBoeuf R. Genetic control of lipid transport in mice. II. Genes controlling structure of high density lipoproteins. J Biol Chem. 1983;258:5071-8 pubmed
    ..Thus, the mouse provides a useful model system for examining the genetic control of mammalian HDL structure and regulation. ..
  21. Chhunchha B, Fatma N, Kubo E, Singh D. Aberrant sumoylation signaling evoked by reactive oxygen species impairs protective function of Prdx6 by destabilization and repression of its transcription. FEBS J. 2014;281:3357-81 pubmed publisher
    Loss of the cytoprotective protein peroxiredoxin 6 (Prdx6) in cells that are aging or under oxidative stress is known to be linked to the pathobiology of many age-related diseases...
  22. Fernandez Valdivia R, Zhang Y, Pai S, Metzker M, Schumacher A. l7Rn6 encodes a novel protein required for clara cell function in mouse lung development. Genetics. 2006;172:389-99 pubmed
    ..Thus, l7Rn6 represents a novel protein required for organization and/or function of the secretory apparatus in Clara cells in mouse lung. ..
  23. Hirota Y, Acar N, Tranguch S, Burnum K, Xie H, Kodama A, et al. Uterine FK506-binding protein 52 (FKBP52)-peroxiredoxin-6 (PRDX6) signaling protects pregnancy from overt oxidative stress. Proc Natl Acad Sci U S A. 2010;107:15577-82 pubmed publisher
    ..Using proteomics analysis, we found that uterine levels of peroxiredoxin-6 (PRDX6), a unique antioxidant, are significantly lower in Fkbp52(-/-) mice than in WT and PR-null (Pgr(-/-)) mice...
  24. Yang D, Bai C, Wang X, An X, Tong L, Bi J. [Roles of peroxiredoxin 6 in the regulation of oxidative stress to lipopolysaccharide-induced acute lung injury]. Zhonghua Jie He He Hu Xi Za Zhi. 2011;34:679-83 pubmed
    ..04). The above parameters were not statistically different between Prdx6 knockout control group and wild-type control group. Deletion of peroxiredoxin 6 exaggerated LPS-induced acute lung injury with increased oxidative stress.
  25. Phelan S, Johnson K, Beier D, Paigen B. Characterization of the murine gene encoding Aop2 (antioxidant protein 2) and identification of two highly related genes. Genomics. 1998;54:132-9 pubmed
    The mouse Aop2 (antioxidant protein 2) cDNA recently cloned from liver and kidney is a member of the thiol-specific antioxidant gene family...
  26. Goldman D, Pikus H. Fourteen genetically variant proteins of mouse brain: discovery of two new variants and chromosomal mapping of four loci. Biochem Genet. 1986;24:183-94 pubmed
    ..In addition to these 13 genetically variant polypeptides, the positions of 12 other polypeptides which have been identified on 2DE gels of mouse brain are given. ..
  27. Frank D, Mendelsohn C, Ciccone E, Svensson K, Ohlsson R, Tycko B. A novel pleckstrin homology-related gene family defined by Ipl/Tssc3, TDAG51, and Tih1: tissue-specific expression, chromosomal location, and parental imprinting. Mamm Genome. 1999;10:1150-9 pubmed
    ..The data also define a new subfamily of PH domain genes. ..
  28. Elliott R, Romejko C, Hohman C. Mapping the gene for LTW-4, a 26,000 molecular weight major protein of mouse liver and kidney. Mol Gen Genet. 1980;180:17-22 pubmed
    ..4 +/- 2.6, between ald and Ltw-4 7.1 +/- 4.6 cM, and between Ltw-4 and Mls 4.3 +/- 2.0 cM. The strain distribution pattern of Ltw-4 is reported for the SWXL recombinant inbred strains and for a large number of inbred strains of mice. ..
  29. Kubo E, Hasanova N, Tanaka Y, Fatma N, Takamura Y, Singh D, et al. Protein expression profiling of lens epithelial cells from Prdx6-depleted mice and their vulnerability to UV radiation exposure. Am J Physiol Cell Physiol. 2010;298:C342-54 pubmed publisher
    Oxidative stress is one of the causative factors in progression and etiology of age-related cataract. Peroxiredoxin 6 (Prdx6), a savior for cells from internal or external environmental stresses, plays a role in cellular signaling by ..
  30. Kim T, Dodia C, Chen X, Hennigan B, Jain M, Feinstein S, et al. Cloning and expression of rat lung acidic Ca(2+)-independent PLA2 and its organ distribution. Am J Physiol. 1998;274:L750-61 pubmed
    A clone for a rat acidic Ca(2+)-independent phospholipase A2 (aiPLA2) was isolated from a cDNA library prepared from rat granular pneumocytes with a probe based on the human aiPLA2 sequence (T.S. Kim, C.S. Sundaresh, S. I. Feinstein, C...
  31. Wang Y, Feinstein S, Manevich Y, Ho Y, Fisher A. Peroxiredoxin 6 gene-targeted mice show increased lung injury with paraquat-induced oxidative stress. Antioxid Redox Signal. 2006;8:229-37 pubmed
    Mice with knock-out of peroxiredoxin 6 (Prdx6), a recently described antioxidant enzyme, were evaluated for susceptibility to lung injury with paraquat (PQ) administration. With high dose PQ (30 mg/kg i.p...
  32. Diet A, Abbas K, Bouton C, Guillon B, Tomasello F, Fourquet S, et al. Regulation of peroxiredoxins by nitric oxide in immunostimulated macrophages. J Biol Chem. 2007;282:36199-205 pubmed
  33. Fatma N, Kubo E, Takamura Y, Ishihara K, Garcia C, Beebe D, et al. Loss of NF-kappaB control and repression of Prdx6 gene transcription by reactive oxygen species-driven SMAD3-mediated transforming growth factor beta signaling. J Biol Chem. 2009;284:22758-72 pubmed publisher
  34. Fisher A, Dodia C, Sorokina E, Li H, Zhou S, Raabe T, et al. A novel lysophosphatidylcholine acyl transferase activity is expressed by peroxiredoxin 6. J Lipid Res. 2016;57:587-96 pubmed publisher
    ..We now describe a lysophosphatidylcholine acyl transferase (LPCAT) activity for Prdx6 that showed a strong preference for lysophosphatidylcholine (LPC) as the head group and for palmitoyl CoA in the ..
  35. Matsumura K, Iwai H, Kato Miyazawa M, Kirikae F, Zhao J, Yanagawa T, et al. Peroxiredoxin 1 Contributes to Host Defenses against Mycobacterium tuberculosis. J Immunol. 2016;197:3233-3244 pubmed
    ..tuberculosis PRDX1 positively regulates IL-12 production by inducing c-Rel and activating p38 MAPK, and it positively regulates NO production by suppressing Arg1 expression in macrophages infected with M. tuberculosis. ..
  36. Phelan S, Wang X, Wallbrandt P, Forsman Semb K, Paigen B. Overexpression of Prdx6 reduces H2O2 but does not prevent diet-induced atherosclerosis in the aortic root. Free Radic Biol Med. 2003;35:1110-20 pubmed
    The mammalian 1-Cys peroxiredoxin (Prdx6) is a unique member of the peroxiredoxin family of proteins capable of protecting cells from metal-catalyzed oxidative damage...
  37. Douville P, Carbonetto S. Genetic linkage analysis in recombinant inbred mice of P40, a putative clone for the high-affinity laminin receptor. Mamm Genome. 1992;3:438-46 pubmed
    ..These P40 loci comprise part of a multimember gene family that is well dispersed in the mouse genome. ..
  38. Hsieh C, Sturm R, Herr W, Francke U. The gene for the ubiquitous octamer-binding protein Oct-1 is on human chromosome 1, region cen-q32, and near Ly-22 and Ltw-4 on mouse chromosome 1. Genomics. 1990;6:666-72 pubmed
    ..There were no recombinants among 26 strains with Ly-22 and 1 recombinant among 24 strains with Ltw-4. The gene symbol is OTF1 for humans and Oct-1 for mouse. ..
  39. Trudel S, Kelly M, Fritsch J, Nguyen Khoa T, Therond P, Couturier M, et al. Peroxiredoxin 6 fails to limit phospholipid peroxidation in lung from Cftr-knockout mice subjected to oxidative challenge. PLoS ONE. 2009;4:e6075 pubmed publisher
    ..despite a strong enzymatic antioxidant response involving superoxide dismutases, glutathione peroxidases and peroxiredoxin 6 (Prdx6). The latter has the unique capacity to directly reduce membrane phospholipid hydroperoxides (PL-OOH)...
  40. Pirson M, Knoops B. Expression of peroxiredoxins and thioredoxins in the mouse spinal cord during embryonic development. J Comp Neurol. 2015;523:2599-617 pubmed publisher
    ..Our results highlight several patterns that contrast with available data for the adult. Indeed, Prdx1, Prdx4, and Prdx6, which are expressed in glial cells in the adult CNS, present clear neuronal localization in mouse spinal cord ..
  41. Wang J, Lin Y, Chen H, Kong X, Xiong H, Shen N, et al. Calcium prevents tumorigenesis in a mouse model of colorectal cancer. PLoS ONE. 2011;6:e22566 pubmed publisher
    ..Defa20, Mmp10, Mmp7, Ptgs2, and Ang2 were among the most downregulated genes, whereas Per3, Tef, Rnf152, and Prdx6 were significantly upregulated in the DMH + Calcium group compared with the DMH group...
  42. Goldman D, Crabbe J. Use of chromosomally mapped and identified mouse brain proteins for behavioral genetic analysis of alcoholism. Prog Neuropsychopharmacol Biol Psychiatry. 1986;10:177-89 pubmed
    ..6 protein) and ethanol intake. Though tentative, these findings illustrate the power of this approach for behavioral genetic analysis and may allow the biochemical genetic bases of these traits to be understood. ..
  43. Wang X, Phelan S, Petros C, Taylor E, Ledinski G, Jurgens G, et al. Peroxiredoxin 6 deficiency and atherosclerosis susceptibility in mice: significance of genetic background for assessing atherosclerosis. Atherosclerosis. 2004;177:61-70 pubmed
    Peroxiredoxin 6 (Prdx6; also called antioxidant protein 2, or Aop2) is a candidate gene for Ath1, a locus responsible for the respective susceptibility and resistance of mouse strains C57BL/6J (B6) and C3H/HeJ (C3H) to diet-induced ..
  44. Sorokina E, Feinstein S, Milovanova T, Fisher A. Identification of the amino acid sequence that targets peroxiredoxin 6 to lysosome-like structures of lung epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2009;297:L871-80 pubmed publisher
    b>Peroxiredoxin 6 (Prdx6), an enzyme with glutathione peroxidase and PLA2 (aiPLA2) activities, is highly expressed in respiratory epithelium, where it participates in phospholipid turnover and antioxidant defense...
  45. Tabakoff B, Bhave S, Hoffman P. Selective breeding, quantitative trait locus analysis, and gene arrays identify candidate genes for complex drug-related behaviors. J Neurosci. 2003;23:4491-8 pubmed
  46. Lee T, Yu S, Kim S, Lee K, Rhee S, Yu D. Characterization of mouse peroxiredoxin I genomic DNA and its expression. Gene. 1999;239:243-50 pubmed
    ..e. the Prx I gene was well conserved in human and mice via its anti-oxidant activity. ..
  47. Li H, Benipal B, Zhou S, Dodia C, Chatterjee S, Tao J, et al. Critical role of peroxiredoxin 6 in the repair of peroxidized cell membranes following oxidative stress. Free Radic Biol Med. 2015;87:356-65 pubmed publisher
    ..b>Peroxiredoxin 6 (Prdx6), a protein with both GSH peroxidase and phospholipase A(2) (PLA(2)) activity, plays a critical role ..
  48. Lee I, Dodia C, Chatterjee S, Feinstein S, Fisher A. Protection against LPS-induced acute lung injury by a mechanism-based inhibitor of NADPH oxidase (type 2). Am J Physiol Lung Cell Mol Physiol. 2014;306:L635-44 pubmed publisher
    The phospholipase A2 activity of peroxiredoxin 6 is inhibited by the transition state analog, 1-hexadecyl-3-(trifluoroethyl)-sn-glycero-2-phosphomethanol (MJ33). This activity is required for the activation of NADPH oxidase, type 2...
  49. Liu G, Feinstein S, Wang Y, Dodia C, Fisher D, Yu K, et al. Comparison of glutathione peroxidase 1 and peroxiredoxin 6 in protection against oxidative stress in the mouse lung. Free Radic Biol Med. 2010;49:1172-81 pubmed publisher
    b>Peroxiredoxin 6 (Prdx6) and cytosolic GSH peroxidase (GPx1), both GSH-dependent peroxidases, were compared for the effects of their knockout on injury and lipid peroxidation in: (a) lungs of mice exposed to 0.85 or 1...
  50. Fisher A, Dodia C, Feinstein S, Ho Y. Altered lung phospholipid metabolism in mice with targeted deletion of lysosomal-type phospholipase A2. J Lipid Res. 2005;46:1248-56 pubmed
    ..This enzyme is identical to peroxiredoxin 6 (Prdx6), a bifunctional protein with PLA2 and GSH peroxidase activities...
  51. Smani T, Zakharov S, Leno E, Csutora P, Trepakova E, Bolotina V. Ca2+-independent phospholipase A2 is a novel determinant of store-operated Ca2+ entry. J Biol Chem. 2003;278:11909-15 pubmed
    ..Thus, functional iPLA(2) is required for activation of store-operated channels and capacitative Ca(2+) influx in wide variety of cell types. ..
  52. Lin L, Wang S, Zhou J. [Effects of yiqi chutan recipe on tumor growth, survival time and expressions of PRDX-1 and PRDX-6 in Lewis lung carcinoma model mice with pi-deficiency syndrome]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2011;31:99-103 pubmed
    ..YCR can remarkably inhibit the growth and metastasis of Lewis lung carcinoma in mice with Pi-asthenia syndrome, prolong their survival period, and its mechanism is possibly related to the reduction of over expressed PRDX-1 and PRDX-6. ..
  53. Panupinthu N, Zhao L, Possmayer F, Ke H, Sims S, Dixon S. P2X7 nucleotide receptors mediate blebbing in osteoblasts through a pathway involving lysophosphatidic acid. J Biol Chem. 2007;282:3403-12 pubmed
    ..This pathway may contribute to P2X7-stimulated osteogenesis during skeletal development and mechanotransduction. ..
  54. Paigen B, Albee D, Holmes P, Mitchell D. Genetic analysis of murine strains C57BL/6J and C3H/HeJ to confirm the map position of Ath-1, a gene determining atherosclerosis susceptibility. Biochem Genet. 1987;25:501-11 pubmed
    ..8 (SE) cM. The phenotypic characteristics of Ath-1 resemble a genetic trait in humans, hyperalphalipoproteinemia, which is characterized by elevated levels of HDL-cholesterol, reduced risk of heart disease, and increased longevity. ..
  55. Krishnaiah S, Dodia C, Feinstein S, Fisher A. p67(phox) terminates the phospholipase A(2)-derived signal for activation of NADPH oxidase (NOX2). FASEB J. 2013;27:2066-73 pubmed publisher
    The phospholipase A2 (PLA2)activity of phosphorylated peroxiredoxin 6 (Prdx6) is required for activation of NADPH oxidase (NOX2). We investigated the interaction of Prdx6 with p67(phox) and its effect on NOX2 activity...
  56. Becamel C, Gavarini S, Chanrion B, Alonso G, Galeotti N, Dumuis A, et al. The serotonin 5-HT2A and 5-HT2C receptors interact with specific sets of PDZ proteins. J Biol Chem. 2004;279:20257-66 pubmed
    ..The interaction of the 5-HT(2A) and the 5-HT(2C) receptor with specific sets of PDZ proteins may contribute to their different signal transduction properties. ..
  57. Yun H, Choi D, Oh K, Hong J. PRDX6 Exacerbates Dopaminergic Neurodegeneration in a MPTP Mouse Model of Parkinson's Disease. Mol Neurobiol. 2015;52:422-31 pubmed publisher
    b>Peroxiredoxin 6 (PRDX6) is a bifunctional protein with both glutathione peroxidase (GPx) and calcium-independent phospholipase A2 (iPLA2) activities...
  58. Reinartz M, Ding Z, Flogel U, Gödecke A, Schrader J. Nitrosative stress leads to protein glutathiolation, increased s-nitrosation, and up-regulation of peroxiredoxins in the heart. J Biol Chem. 2008;283:17440-9 pubmed publisher
    ..Furthermore, S-nitrosation of Prxs may serve a new function in the signaling cascade of nitrosative stress. ..
  59. Godoy J, Oesteritz S, Hanschmann E, Ockenga W, Ackermann W, Lillig C. Segment-specific overexpression of redoxins after renal ischemia and reperfusion: protective roles of glutaredoxin 2, peroxiredoxin 3, and peroxiredoxin 6. Free Radic Biol Med. 2011;51:552-61 pubmed publisher
  60. Shan S, Tang M, Cai D, Chui Y, Chow P, Grotewold L, et al. Comparative proteomic analysis identifies protein disulfide isomerase and peroxiredoxin 1 as new players involved in embryonic interdigital cell death. Dev Dyn. 2005;233:266-81 pubmed
    ..Taken together, our study identifies two new players in interdigital cell death and highlights that PCD is regulated by a delicate balance of proapoptotic and survival-promoting activities. ..
  61. Lyman S, Poland A, Taylor B. Genetic polymorphism of microsomal epoxide hydrolase activity in the mouse. J Biol Chem. 1980;255:8650-4 pubmed
    ..Using 24 recombinant inbred strains derived from C57BL/6J and DBA/2J mice, Eph-1 was found to be linked to two loci on Chromosome 1. ..
  62. Ishii T, Yamada M, Sato H, Matsue M, Taketani S, Nakayama K, et al. Cloning and characterization of a 23-kDa stress-induced mouse peritoneal macrophage protein. J Biol Chem. 1993;268:18633-6 pubmed
    ..One of the proteins is the C22 component of alkyl hydroperoxide reductase, which is induced by hydrogen peroxide in Salmonella typhimurium. ..
  63. Iakoubova O, Pacella L, Her H, Beier D. LTW4 protein on mouse chromosome 1 is a member of a family of antioxidant proteins. Genomics. 1997;42:474-8 pubmed
    ..The murine MER5 gene is also a member of this gene family and has recently been renamed Antioxidant protein 1 (Aop1), based on its functional characterization. We therefore propose that the gene encoding LTW4 be called Aop2.
  64. Bast A, Erttmann S, Walther R, Steinmetz I. Influence of iNOS and COX on peroxiredoxin gene expression in primary macrophages. Free Radic Biol Med. 2010;49:1881-91 pubmed publisher
    ..Taken together our results indicate a possible role for Prxs in defense mechanisms of activated macrophages against oxidative stress during inflammation or infection. ..
  65. Lien Y, Feinstein S, Dodia C, Fisher A. The roles of peroxidase and phospholipase A2 activities of peroxiredoxin 6 in protecting pulmonary microvascular endothelial cells against peroxidative stress. Antioxid Redox Signal. 2012;16:440-51 pubmed publisher
    b>Peroxiredoxin 6 (Prdx6), a bifunctional enzyme with glutathione peroxidase and phospholipase A(2) (PLA(2)) activities, has been demonstrated as playing a critical role in antioxidant defense of the lung...
  66. Lee I, Choi W, Kim J, Jeong J, Kim M, Nam J, et al. Transcriptional regulation of the murine 1-cys peroxiredoxin gene by the B cell-specific activator protein, Pax5. J Cell Biochem. 2008;104:465-76 pubmed publisher
    ..Lipopolysaccharides (LPS) stimulation of murine splenocytes resulted in coordinated expression of Pax5 and 1-cysPrx proteins. These findings suggest that Pax5 may function as a transactivator of 1-cysPrx gene expression. ..
  67. Goldman D, Nelson R, Deitrich R, Baker R, Spuhler K, Markley H, et al. Genetic brain polypeptide variants in inbred mice and in mouse strains with high and low sensitivity to alcohol. Brain Res. 1985;341:130-8 pubmed
    ..abstract truncated at 250 words) ..