Gene Symbol: Prdx4
Description: peroxiredoxin 4
Alias: AOE372, Prx-iv, Prx4, TRANK, peroxiredoxin-4, Prx IV, antioxidant enzyme AOE372, peroxiredoxin IV, thioredoxin peroxidase AO372, thioredoxin-dependent peroxide reductase A0372
Species: mouse
Products:     Prdx4

Top Publications

  1. Iuchi Y, Okada F, Tsunoda S, Kibe N, Shirasawa N, Ikawa M, et al. Peroxiredoxin 4 knockout results in elevated spermatogenic cell death via oxidative stress. Biochem J. 2009;419:149-58 pubmed publisher
    Prx (peroxiredoxin) is a multifunctional redox protein with thioredoxin-dependent peroxidase activity. Prx4 is present as a secretory protein in most tissues, whereas in sexually mature testes it is anchored in the ER (endoplasmic ..
  2. Zito E, Hansen H, Yeo G, Fujii J, Ron D. Endoplasmic reticulum thiol oxidase deficiency leads to ascorbic acid depletion and noncanonical scurvy in mice. Mol Cell. 2012;48:39-51 pubmed publisher
    ..We found that combined loss-of-function mutations in genes encoding the ER thiol oxidases ERO1α, ERO1β, and PRDX4 compromised the extracellular matrix in mice and interfered with the intracellular maturation of procollagen...
  3. Shan S, Tang M, Cai D, Chui Y, Chow P, Grotewold L, et al. Comparative proteomic analysis identifies protein disulfide isomerase and peroxiredoxin 1 as new players involved in embryonic interdigital cell death. Dev Dyn. 2005;233:266-81 pubmed
    ..Taken together, our study identifies two new players in interdigital cell death and highlights that PCD is regulated by a delicate balance of proapoptotic and survival-promoting activities. ..
  4. Kim T, Song J, Alcantara Llaguno S, Murnan E, Liyanarachchi S, Palanichamy K, et al. Suppression of peroxiredoxin 4 in glioblastoma cells increases apoptosis and reduces tumor growth. PLoS ONE. 2012;7:e42818 pubmed publisher
    ..Here, we report that peroxiredoxin 4 (PRDX4) is a putative tumor driver...
  5. Avezov E, Cross B, Kaminski Schierle G, Winters M, Harding H, Melo E, et al. Lifetime imaging of a fluorescent protein sensor reveals surprising stability of ER thiol redox. J Cell Biol. 2013;201:337-49 pubmed publisher
    ..These findings recommend fluorescent lifetime imaging as a sensitive method to track ER redox homeostasis in mammalian cells. ..
  6. Qian Y, Shao L, Yuan C, Jiang C, Liu J, Gao C, et al. Implication of Differential Peroxiredoxin 4 Expression with Age in Ovaries of Mouse and Human for Ovarian Aging. Curr Mol Med. 2016;16:243-51 pubmed
    ..The antioxidant peroxiredoxin 4 (Prdx4), as a member of Prdx protein family, controls cellular oxidative stress by reducing H2O2 levels...
  7. Lee T, Yu S, Kim S, Lee K, Rhee S, Yu D. Characterization of mouse peroxiredoxin I genomic DNA and its expression. Gene. 1999;239:243-50 pubmed
    ..e. the Prx I gene was well conserved in human and mice via its anti-oxidant activity. ..
  8. Nabeshima A, Yamada S, Guo X, Tanimoto A, Wang K, Shimajiri S, et al. Peroxiredoxin 4 protects against nonalcoholic steatohepatitis and type 2 diabetes in a nongenetic mouse model. Antioxid Redox Signal. 2013;19:1983-98 pubmed publisher
    ..b>Peroxiredoxin 4 (PRDX4) is a unique and only known secretory member of the PRDX antioxidant family...
  9. Yan Y, Wladyka C, Fujii J, Sockanathan S. Prdx4 is a compartment-specific H2O2 sensor that regulates neurogenesis by controlling surface expression of GDE2. Nat Commun. 2015;6:7006 pubmed publisher
    ..Here we show that Prdx4, an endoplasmic reticulum (ER) enzyme that metabolizes H2O2, acts as a tunable regulator of neurogenesis via its ..

More Information


  1. Nawata A, Noguchi H, Mazaki Y, Kurahashi T, Izumi H, Wang K, et al. Overexpression of Peroxiredoxin 4 Affects Intestinal Function in a Dietary Mouse Model of Nonalcoholic Fatty Liver Disease. PLoS ONE. 2016;11:e0152549 pubmed publisher
    ..We have reported that peroxiredoxin 4 (PRDX4), a unique secretory member of the PRDX antioxidant family, protects against NAFLD progression...
  2. Wong C, Chun A, Kok K, Zhou Y, Fung P, Kung H, et al. Characterization of human and mouse peroxiredoxin IV: evidence for inhibition by Prx-IV of epidermal growth factor- and p53-induced reactive oxygen species. Antioxid Redox Signal. 2000;2:507-18 pubmed
    The aim of this study was to identify and characterize human and mouse Prx-IV. We identified mouse peroxiredoxin IV (Prx-IV) by virtue of sequence homology to its human ortholog previously called AOE372...
  3. Meng Y, Liu X, Ma X, Shen Y, Fan L, Leng J, et al. The protein profile of mouse mature cumulus-oocyte complex. Biochim Biophys Acta. 2007;1774:1477-90 pubmed
    ..These data provide valuable information for future studies to identify proteins involved in ovarian follicular development and related reproductive abnormalities. ..
  4. Yim S, Kim Y, Oh S, Fujii J, Zhang Y, Gladyshev V, et al. Identification and characterization of alternatively transcribed form of peroxiredoxin IV gene that is specifically expressed in spermatids of postpubertal mouse testis. J Biol Chem. 2011;286:39002-12 pubmed publisher
    ..b>Prx IV was shown previously to be synthesized as a 31-kDa polypeptide with an NH(2)-terminal signal peptide that is ..
  5. Kojima R, Okumura M, Masui S, Kanemura S, Inoue M, Saiki M, et al. Radically different thioredoxin domain arrangement of ERp46, an efficient disulfide bond introducer of the mammalian PDI family. Structure. 2014;22:431-43 pubmed publisher
    ..disulfide isomerase (PDI) family, serves as an efficient disulfide bond introducer together with Peroxiredoxin-4 (Prx4)...
  6. Pirson M, Knoops B. Expression of peroxiredoxins and thioredoxins in the mouse spinal cord during embryonic development. J Comp Neurol. 2015;523:2599-617 pubmed publisher
    ..Our results highlight several patterns that contrast with available data for the adult. Indeed, Prdx1, Prdx4, and Prdx6, which are expressed in glial cells in the adult CNS, present clear neuronal localization in mouse ..