Ppp2ca

Summary

Gene Symbol: Ppp2ca
Description: protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform
Alias: PP2A, R75353, serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform, PP2A-alpha, protein phosphatase 2a, catalytic subunit, alpha isoform
Species: mouse
Products:     Ppp2ca

Top Publications

  1. Gu P, Qi X, Zhou Y, Wang Y, Gao X. Generation of Ppp2Ca and Ppp2Cb conditional null alleles in mouse. Genesis. 2012;50:429-36 pubmed publisher
    ..There are two isoforms of the catalytic subunit of PP2A, Ppp2ca and Ppp2cb. Null mutation of Ppp2ca leads to early embryonic lethality at E6...
  2. Sontag J, Nunbhakdi Craig V, Mitterhuber M, Ogris E, Sontag E. Regulation of protein phosphatase 2A methylation by LCMT1 and PME-1 plays a critical role in differentiation of neuroblastoma cells. J Neurochem. 2010;115:1455-65 pubmed publisher
    Neuritic alterations are a major feature of many neurodegenerative disorders. Methylation of protein phosphatase 2A (PP2A) catalytic C subunit by the leucine carboxyl methyltransferase (LCMT1), and demethylation by the protein phosphatase ..
  3. Gotz J, Probst A, Ehler E, Hemmings B, Kues W. Delayed embryonic lethality in mice lacking protein phosphatase 2A catalytic subunit Calpha. Proc Natl Acad Sci U S A. 1998;95:12370-5 pubmed
    Protein phosphatase 2A (PP2A) is a multimeric enzyme, containing a catalytic subunit complexed with two regulatory subunits. The catalytic subunit PP2A C is encoded by two distinct and unlinked genes, termed Calpha and Cbeta...
  4. Chung H, Nairn A, Murata K, Brautigan D. Mutation of Tyr307 and Leu309 in the protein phosphatase 2A catalytic subunit favors association with the alpha 4 subunit which promotes dephosphorylation of elongation factor-2. Biochemistry. 1999;38:10371-6 pubmed
    The cellular location and substrate specificity of the catalytic subunit (C) of protein phosphatase 2A (PP2A) depend on its interaction with A and B subunits...
  5. Chen J, Parsons S, Brautigan D. Tyrosine phosphorylation of protein phosphatase 2A in response to growth stimulation and v-src transformation of fibroblasts. J Biol Chem. 1994;269:7957-62 pubmed
    The catalytic subunit of protein phosphatase 2A (PP2A) is inactivated by in vitro phosphorylation of Tyr307 by receptor and nonreceptor protein tyrosine kinases (Chen, J., Martin, B. L., and Brautigan, D. L. (1992) Science 257, 1261-1264)...
  6. Nawa M, Kanekura K, Hashimoto Y, Aiso S, Matsuoka M. A novel Akt/PKB-interacting protein promotes cell adhesion and inhibits familial amyotrophic lateral sclerosis-linked mutant SOD1-induced neuronal death via inhibition of PP2A-mediated dephosphorylation of Akt/PKB. Cell Signal. 2008;20:493-505 pubmed
    ..In vitro analysis indicated that BTBD10 bound to protein phosphatase 2A (PP2A) and inhibited dephosphorylation of Akts by PP2A...
  7. Cho U, Morrone S, Sablina A, Arroyo J, Hahn W, Xu W. Structural basis of PP2A inhibition by small t antigen. PLoS Biol. 2007;5:e202 pubmed
    The SV40 small t antigen (ST) is a potent oncoprotein that perturbs the function of protein phosphatase 2A (PP2A)...
  8. Ruediger R, Ruiz J, Walter G. Human cancer-associated mutations in the A? subunit of protein phosphatase 2A increase lung cancer incidence in A? knock-in and knockout mice. Mol Cell Biol. 2011;31:3832-44 pubmed publisher
    Strong evidence has indicated that protein phosphatase 2A (PP2A) is a tumor suppressor, but a mouse model for testing the tumor suppressor activity was missing...
  9. Xiong Y, Jing X, Zhou X, Wang X, Yang Y, Sun X, et al. Zinc induces protein phosphatase 2A inactivation and tau hyperphosphorylation through Src dependent PP2A (tyrosine 307) phosphorylation. Neurobiol Aging. 2013;34:745-56 pubmed publisher
    ..and promotes the hyperphosphorylation of tau in the brains of Alzheimer's disease (AD), but the mechanism for PP2A inactivation has not been elucidated...

More Information

Publications62

  1. Ortega Gutierrez S, Leung D, Ficarro S, Peters E, Cravatt B. Targeted disruption of the PME-1 gene causes loss of demethylated PP2A and perinatal lethality in mice. PLoS ONE. 2008;3:e2486 pubmed publisher
    Phosphoprotein phosphatase 2A (PP2A), a major serine-threonine protein phosphatase in eukaryotes, is an oligomeric protein comprised of structural (A) and catalytic (C) subunits to which a variable regulatory subunit (B) can associate...
  2. Gotz J, Probst A, Mistl C, Nitsch R, Ehler E. Distinct role of protein phosphatase 2A subunit Calpha in the regulation of E-cadherin and beta-catenin during development. Mech Dev. 2000;93:83-93 pubmed
    Protein phosphatase 2A (PP2A) plays central roles in development, cell growth and transformation. Inactivation of the gene encoding the PP2A catalytic subunit Calpha by gene targeting generates a lethal embryonic phenotype...
  3. Wang Y, Yang R, Gu J, Yin X, Jin N, Xie S, et al. Cross talk between PI3K-AKT-GSK-3β and PP2A pathways determines tau hyperphosphorylation. Neurobiol Aging. 2015;36:188-200 pubmed publisher
    Glycogen synthase kinase-3β (GSK-3β) and protein phosphatase 2A (PP2A) are the important enzymes controlling tau hyperphosphorylation...
  4. Perera N, Sheean R, Scott J, Kemp B, Horne M, Turner B. Mutant TDP-43 deregulates AMPK activation by PP2A in ALS models. PLoS ONE. 2014;9:e90449 pubmed publisher
    ..We show that mutant TDP-43 induction of the AMPK phosphatase,protein phosphatase 2A (PP2A), is associated with AMPK inactivation in these ALS models...
  5. Jackson J, Young M. Protein phosphatase-2A regulates protein tyrosine phosphatase activity in Lewis lung carcinoma tumor variants. Clin Exp Metastasis. 2003;20:357-64 pubmed
  6. Wong P, Feng Y, Wang J, Shi R, Jiang X. Regulation of autophagy by coordinated action of mTORC1 and protein phosphatase 2A. Nat Commun. 2015;6:8048 pubmed publisher
    ..We identify the starvation-stimulated phosphatase for ULK1 as the PP2A-B55α complex...
  7. Crossthwaite A, Ciruela A, Rayner T, Cooper D. A direct interaction between the N terminus of adenylyl cyclase AC8 and the catalytic subunit of protein phosphatase 2A. Mol Pharmacol. 2006;69:608-17 pubmed
    ..HEK) 293 cell cDNA library and identified the catalytic subunit of the serine/threonine protein phosphatase 2A (PP2A(C)) as a binding partner...
  8. Qiu Q, Zheng Z, Chang L, Zhao Y, Tan C, Dandekar A, et al. Toll-like receptor-mediated IRE1? activation as a therapeutic target for inflammatory arthritis. EMBO J. 2013;32:2477-90 pubmed publisher
    ..IRE1? activation by catalysing IRE1? ubiquitination and blocking the recruitment of protein phosphatase 2A (PP2A), a phosphatase that inhibits IRE1? phosphorylation...
  9. Martín Ávila A, Medina Tamayo J, Ibarra Sanchez A, Vázquez Victorio G, Castillo Arellano J, Hernández Mondragón A, et al. Protein Tyrosine Kinase Fyn Regulates TLR4-Elicited Responses on Mast Cells Controlling the Function of a PP2A-PKC?/? Signaling Node Leading to TNF Secretion. J Immunol. 2016;196:5075-88 pubmed publisher
    ..Increased responsiveness in Fyn(-/-) cells was associated with a lower activity of protein phosphatase 2A (PP2A) and augmented activity of protein kinase C (PKC)?/?, which was dissociated from PP2A and increased its association ..
  10. Vasudevan N, Mohan M, Gupta M, Hussain A, Naga Prasad S. Inhibition of protein phosphatase 2A activity by PI3K? regulates ?-adrenergic receptor function. Mol Cell. 2011;41:636-48 pubmed publisher
    ..We show here that PI3K? inhibits protein phosphatase 2A (PP2A) at the ?-adrenergic receptor (?AR, a GPCR) complex altering G protein coupling...
  11. Chen W, Gu P, Jiang X, Ruan H, Li C, Gao X. Protein phosphatase 2A catalytic subunit ? (PP2Ac?) maintains survival of committed erythroid cells in fetal liver erythropoiesis through the STAT5 pathway. Am J Pathol. 2011;178:2333-43 pubmed publisher
    ..As the major eukaryotic serine/threonine phosphatase, protein phosphatase 2A (PP2A) regulates multiple cellular processes, including apoptosis...
  12. Guenebeaud C, Goldschneider D, Castets M, Guix C, Chazot G, Delloye Bourgeois C, et al. The dependence receptor UNC5H2/B triggers apoptosis via PP2A-mediated dephosphorylation of DAP kinase. Mol Cell. 2010;40:863-76 pubmed publisher
    ..in UNC5H-induced apoptosis, we identified the structural subunit PR65? of the holoenzyme protein phosphatase 2A (PP2A). We show that UNC5H2/B recruits a protein complex that includes PR65? and DAPk and retains PP2A activity...
  13. Yang D, Okamura H, Morimoto H, Teramachi J, Haneji T. Protein phosphatase 2A C? regulates proliferation, migration, and metastasis of osteosarcoma cells. Lab Invest. 2016;96:1050-62 pubmed publisher
    Osteosarcoma is the most frequent primary bone tumor. Serine/threonine protein phosphatase 2A (PP2A) participates in regulating many important physiological processes, such as cell cycle, growth, apoptosis, and signal transduction...
  14. Machka C, Kersten M, Zobawa M, Harder A, Horsch M, Halder T, et al. Identification of Dll1 (Delta1) target genes during mouse embryogenesis using differential expression profiling. Gene Expr Patterns. 2005;6:94-101 pubmed
    ..The large set of regulated genes identified in this differential expression profiling approach is an important resource for further functional studies. ..
  15. Le Guelte A, Galan Moya E, Dwyer J, Treps L, Kettler G, Hebda J, et al. Semaphorin 3A elevates endothelial cell permeability through PP2A inactivation. J Cell Sci. 2012;125:4137-46 pubmed publisher
    ..From a mechanistic standpoint, Semaphorin 3A impinged upon the basal activity of the serine phosphatase PP2A and disrupted PP2A interaction with VE-cadherin, leading to cell-cell junction disorganization and increased ..
  16. Ling S, Sun Q, Li Y, Zhang L, Zhang P, Wang X, et al. CKIP-1 inhibits cardiac hypertrophy by regulating class II histone deacetylase phosphorylation through recruiting PP2A. Circulation. 2012;126:3028-40 pubmed publisher
    ..These results demonstrated a unique function of CKIP-1, by which it suppresses cardiac hypertrophy through its capacity to regulate HDAC4 dephosphorylation and fetal cardiac genes expression. ..
  17. Oaks J, Santhanam R, Walker C, Roof S, Harb J, Ferenchak G, et al. Antagonistic activities of the immunomodulator and PP2A-activating drug FTY720 (Fingolimod, Gilenya) in Jak2-driven hematologic malignancies. Blood. 2013;122:1923-34 pubmed publisher
    ..FTY720 is also a potent protein phosphatase 2A (PP2A)-activating drug (PAD). PP2A is a tumor suppressor found inactivated in different types of cancer...
  18. Beaulieu J, Sotnikova T, Marion S, Lefkowitz R, Gainetdinov R, Caron M. An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior. Cell. 2005;122:261-73 pubmed
    ..D2 class-receptor-mediated Akt regulation involves the formation of signaling complexes containing beta-arrestin 2, PP2A, and Akt...
  19. Xie L, Liu C, Wang L, Gunawardena H, Yu Y, Du R, et al. Protein phosphatase 2A catalytic subunit ? plays a MyD88-dependent, central role in the gene-specific regulation of endotoxin tolerance. Cell Rep. 2013;3:678-88 pubmed publisher
  20. Kanematsu T, Yasunaga A, Mizoguchi Y, Kuratani A, Kittler J, Jovanovic J, et al. Modulation of GABA(A) receptor phosphorylation and membrane trafficking by phospholipase C-related inactive protein/protein phosphatase 1 and 2A signaling complex underlying brain-derived neurotrophic factor-dependent regulation of GABAergic inhibiti. J Biol Chem. 2006;281:22180-9 pubmed
    ..Together, the results suggest that PRIP plays an important role in BDNF-dependent regulation of GABA(A) receptors by mediating the specific association between beta subunits of these receptors with protein phosphatases. ..
  21. Brüchert N, Mavila N, Boknik P, Baba H, Fabritz L, Gergs U, et al. Inhibitor-2 prevents protein phosphatase 1-induced cardiac hypertrophy and mortality. Am J Physiol Heart Circ Physiol. 2008;295:H1539-46 pubmed publisher
    ..Therefore, PP1 inhibitors such as I-2 could offer new therapeutic options to ameliorate the deleterious effects of heart failure. ..
  22. Ohama T, Brautigan D. Endotoxin conditioning induces VCP/p97-mediated and inducible nitric-oxide synthase-dependent Tyr284 nitration in protein phosphatase 2A. J Biol Chem. 2010;285:8711-8 pubmed publisher
    ..We purified the lipopolysaccharide-induced form of PP2A by chromatography plus immunoprecipitation and used mass spectrometry to identify VCP/p97 as a novel partner for ..
  23. Chang H, Jennings P, Stewart J, Verrills N, Jones K. Essential role of protein phosphatase 2A in metaphase II arrest and activation of mouse eggs shown by okadaic acid, dominant negative protein phosphatase 2A, and FTY720. J Biol Chem. 2011;286:14705-12 pubmed publisher
    ..Therefore, we explored the role of protein phosphatase 2A (PP2A) in mouse eggs using pharmacological inhibition and activation as well as a functionally dominant-negative ..
  24. Hoffmeister M, Prelle C, Küchler P, Kovacevic I, Moser M, Müller Esterl W, et al. The ubiquitin E3 ligase NOSIP modulates protein phosphatase 2A activity in craniofacial development. PLoS ONE. 2014;9:e116150 pubmed publisher
    ..based protein interaction screen we identified NOSIP as a novel interaction partner of protein phosphatase PP2A. NOSIP mediates the monoubiquitination of the PP2A catalytic subunit and the loss of NOSIP results in an increase ..
  25. Li G, Ji X, Gao H, Zhao J, Xu J, Sun Z, et al. EphB3 suppresses non-small-cell lung cancer metastasis via a PP2A/RACK1/Akt signalling complex. Nat Commun. 2012;3:667 pubmed publisher
  26. Giorgi C, Ito K, Lin H, Santangelo C, Wieckowski M, Lebiedzinska M, et al. PML regulates apoptosis at endoplasmic reticulum by modulating calcium release. Science. 2010;330:1247-51 pubmed publisher
    ..size with the inositol 1,4,5-trisphosphate receptor (IP(3)R), protein kinase Akt, and protein phosphatase 2a (PP2a)...
  27. Bertoli C, Copetti T, Lam E, Demarchi F, Schneider C. Calpain small-1 modulates Akt/FoxO3A signaling and apoptosis through PP2A. Oncogene. 2009;28:721-33 pubmed publisher
    ..Both okadaic acid treatment and silencing of the protein phosphatase 2A (PP2A) catalytic subunit can partially reduce starvation-induced FoxO3A activation and apoptosis in CAPNS1-/- fibroblasts...
  28. Kong M, Ditsworth D, Lindsten T, Thompson C. Alpha4 is an essential regulator of PP2A phosphatase activity. Mol Cell. 2009;36:51-60 pubmed publisher
    ..alpha4 is an evolutionarily conserved noncatalytic subunit for PP2A-like phosphatases...
  29. McHugh W, Russell W, Fleszar A, Rodenhouse P, Rietberg S, Sun L, et al. Protein phosphatase 2A activation attenuates inflammation in murine models of acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2016;311:L903-L912 pubmed publisher
    ..Protein phosphatase 2A (PP2A) has been shown to be a key regulator of the mitogen-activated protein kinase (MAPK) cascades, which control the ..
  30. Zhang Y, Jiang X, Qin C, Cuevas S, Jose P, Armando I. Dopamine D2 receptors' effects on renal inflammation are mediated by regulation of PP2A function. Am J Physiol Renal Physiol. 2016;310:F128-34 pubmed publisher
    ..Inhibition of protein phosphatase 2A (PP2A) with okadaic acid reproduced the effects of D2R downregulation on Akt, GSK3β, and cyclin D1...
  31. Xiao Y, Freire de Lima C, Janssen W, Morimoto K, Lyu D, Bratton D, et al. Oxidants selectively reverse TGF-beta suppression of proinflammatory mediator production. J Immunol. 2006;176:1209-17 pubmed
    ..This was mediated through Src tyrosine kinases and protein phosphatase-1/2A. By contrast, hydrogen peroxide had no effects on TGF-beta-induced Smad2 phosphorylation and SBE-luc reporter gene transcription. ..
  32. Mackay K, Tu Y, Young S, Clarke S. Circumventing embryonic lethality with Lcmt1 deficiency: generation of hypomorphic Lcmt1 mice with reduced protein phosphatase 2A methyltransferase expression and defects in insulin signaling. PLoS ONE. 2013;8:e65967 pubmed publisher
    Protein phosphatase 2A (PP2A), the major serine/threonine phosphatase in eukaryotic cells, is a heterotrimeric protein composed of structural, catalytic, and targeting subunits...
  33. Taira J, Kida Y, Kuwano K, Higashimoto Y. Protein phosphatase 2A dephosphorylates phosphoserines in nucleocytoplasmic shuttling and secretion of high mobility group box 1. J Biochem. 2013;154:299-308 pubmed publisher
    ..Herein, we demonstrate the physical interaction between HMGB1 and protein phosphatase 2A (PP2A) in the RAW264.7...
  34. Fakira A, Portugal G, Carusillo B, Melyan Z, Morón J. Increased small conductance calcium-activated potassium type 2 channel-mediated negative feedback on N-methyl-D-aspartate receptors impairs synaptic plasticity following context-dependent sensitization to morphine. Biol Psychiatry. 2014;75:105-14 pubmed publisher
    ..After the challenge, the hippocampi were removed to assay phosphatase 2A (PP2A) activity, NMDAR, and SK2 channel synaptic expression or to perform electrophysiological recordings...
  35. Okamura H, Yang D, Yoshida K, Haneji T. Protein phosphatase 2A C? is involved in osteoclastogenesis by regulating RANKL and OPG expression in osteoblasts. FEBS Lett. 2013;587:48-53 pubmed publisher
    We examined whether alteration of PP2A C? expression in osteoblasts is involved in osteoclast differentiation...
  36. Bollag B, Hofstetter C, Reviriego Mendoza M, Frisque R. JC virus small T antigen binds phosphatase PP2A and Rb family proteins and is required for efficient viral DNA replication activity. PLoS ONE. 2010;5:e10606 pubmed publisher
    ..at a conserved proline, which in the SV40 tAg is required for efficient interaction with protein phosphatase 2A (PP2A), and the C157A mutant tAg is altered at one of two newly recognized LxCxE motifs...
  37. Bottiglieri T, Arning E, Wasek B, Nunbhakdi Craig V, Sontag J, Sontag E. Acute administration of L-DOPA induces changes in methylation metabolites, reduced protein phosphatase 2A methylation, and hyperphosphorylation of Tau protein in mouse brain. J Neurosci. 2012;32:9173-81 pubmed publisher
    ..enzymes, including leucine carboxyl methyltransferase that specifically methylates Ser/Thr protein phosphatase 2A (PP2A), a major Tau phosphatase...
  38. Kickstein E, Krauss S, Thornhill P, Rutschow D, Zeller R, Sharkey J, et al. Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling. Proc Natl Acad Sci U S A. 2010;107:21830-5 pubmed publisher
    ..Though diverse kinases have been implicated in tau phosphorylation, protein phosphatase 2A (PP2A) seems to be the major tau phosphatase...
  39. Xian L, Hou S, Huang Z, Tang A, Shi P, Wang Q, et al. Liver-specific deletion of Ppp2cα enhances glucose metabolism and insulin sensitivity. Aging (Albany NY). 2015;7:223-32 pubmed
    Protein phosphatase 2A (PP2A) is a key negative regulator of phosphatidylinositol 3-kinase/Akt pathway...
  40. Wang L, Wang X, Chen J, Yang Z, Yu L, Hu L, et al. Activation of protein serine/threonine phosphatase PP2C? efficiently prevents liver fibrosis. PLoS ONE. 2010;5:e14230 pubmed publisher
    ..Moreover, our study might provide the first evidence for the role of PP2C family members in the fibrotic disease. ..
  41. LeNoue Newton M, Watkins G, Zou P, Germane K, McCorvey L, Wadzinski B, et al. The E3 ubiquitin ligase- and protein phosphatase 2A (PP2A)-binding domains of the Alpha4 protein are both required for Alpha4 to inhibit PP2A degradation. J Biol Chem. 2011;286:17665-71 pubmed publisher
    Protein phosphatase 2A (PP2A) is regulated through a variety of mechanisms, including post-translational modifications and association with regulatory proteins...
  42. Lin S, Lee Y, Wang J, Miller S, Chiou S, Hung M, et al. Survival of cancer stem cells under hypoxia and serum depletion via decrease in PP2A activity and activation of p38-MAPKAPK2-Hsp27. PLoS ONE. 2012;7:e49605 pubmed publisher
    ..Thus, activation of PP2A or inactivation of the p38MAPK-MAPKAPK2-Hsp27 pathway may develop new strategies for cancer therapy by suppression ..
  43. Vacaru A, den Hertog J. Serine dephosphorylation of receptor protein tyrosine phosphatase alpha in mitosis induces Src binding and activation. Mol Cell Biol. 2010;30:2850-61 pubmed publisher
    ..and knockdown experiments, we demonstrated that dephosphorylation of RPTPalpha pSer204 in mitosis was mediated by PP2A. Mutation of Ser204 to Ala did not activate RPTPalpha, and intrinsic catalytic activity of RPTPalpha was not ..
  44. Apostolidis S, Rauen T, Hedrich C, Tsokos G, Crispin J. Protein phosphatase 2A enables expression of interleukin 17 (IL-17) through chromatin remodeling. J Biol Chem. 2013;288:26775-84 pubmed publisher
    Protein phosphatase 2A (PP2A) is a heterotrimeric serine/threonine phosphatase involved in essential cellular functions...
  45. Park S, Jung H, Kim Y, Park T, Kim C, Choi H, et al. Asp664 cleavage of amyloid precursor protein induces tau phosphorylation by decreasing protein phosphatase 2A activity. J Neurochem. 2012;123:856-65 pubmed publisher
    ..Compared with wild-type APP, protein phosphatase 2A (PP2A) activity was significantly increased when Asp664 cleavage was blocked by the D664A point mutation...
  46. Chen S, Huang S, Lu C, Hsu Y, Wang D. Microvascular dysfunction with increased vascular leakage response in mice systemically exposed to arsenic. Cardiovasc Toxicol. 2014;14:222-31 pubmed publisher
    ..have an increased vascular leakage response to vasoactive agents and whether enhanced type-2 protein phosphatase (PP2A) activity is involved in mustard oil-induced leakage...
  47. Li L, Fang C, Xu D, Xu Y, Fu H, Li J. Cardiomyocyte specific deletion of PP2A causes cardiac hypertrophy. Am J Transl Res. 2016;8:1769-79 pubmed
    ..Cardiac function of mice was determined by echocardiography. Decrease in PP2A activity leads to increased cardiomyocyte hypertrophy and fibrosis...
  48. Wang Y, Xia Y, Kuang D, Duan Y, Wang G. PP2A regulates SCF-induced cardiac stem cell migration through interaction with p38 MAPK. Life Sci. 2017;191:59-67 pubmed publisher
    ..Earlier studies on the migration mechanism only focused on the activation of kinases; here, we aimed to explore the functional role of protein phosphatase 2A (PP2A) in SCF-induced CSC migration.
  49. Okamura H, Yoshida K, Yang D, Haneji T. Protein phosphatase 2A C? regulates osteoblast differentiation and the expressions of bone sialoprotein and osteocalcin via osterix transcription factor. J Cell Physiol. 2013;228:1031-7 pubmed publisher
    Serine/threonine protein phosphatase 2A (PP2A) participates in regulating many important physiological processes such as cell cycle, growth, apoptosis, and signal transduction...
  50. Deepa S, Zhou L, Ryu J, Wang C, Mao X, Li C, et al. APPL1 mediates adiponectin-induced LKB1 cytosolic localization through the PP2A-PKCzeta signaling pathway. Mol Endocrinol. 2011;25:1773-85 pubmed publisher
    ..demonstrate that treating C2C12 myotubes with adiponectin promoted APPL1 interaction with protein phosphatase 2A (PP2A) and protein kinase C? (PKC?), leading to the activation of PP2A and subsequent dephosphorylation and inactivation ..
  51. Prickett T, Brautigan D. The alpha4 regulatory subunit exerts opposing allosteric effects on protein phosphatases PP6 and PP2A. J Biol Chem. 2006;281:30503-11 pubmed
    The protein Ser/Thr phosphatase family contains three enzymes called PP2A, PP4, and PP6 with separate biological functions inferred from genetics of the yeast homologues Pph21/22, Pph3, and Sit4...
  52. Weston W, Freeman A, Haberecht C, Hackmiller R, Ma L, Nugent P, et al. Phosphatase regulation of gene expression during development of the palate. Life Sci. 2002;71:1849-62 pubmed
    ..These results demonstrate that transcriptional regulation of CREB in embryonic palatal issue is dependent on the coordinate activity of specific kinases and phosphatases. ..
  53. Veeranna -, Yang D, Lee J, Vinod K, Stavrides P, Amin N, et al. Declining phosphatases underlie aging-related hyperphosphorylation of neurofilaments. Neurobiol Aging. 2011;32:2016-29 pubmed publisher
    ..Purified PP2A or PP2B dephosphorylated the heavy neurofilament (NFH) subunit or its extensively phorphorylated carboxyl-terminal ..