Gene Symbol: Ppp1r11
Description: protein phosphatase 1, regulatory (inhibitor) subunit 11
Alias: 1500041B02Rik, AV117883, Hcgv, Tcte5, Tctex-5, Tctex5, E3 ubiquitin-protein ligase PPP1R11, T-complex testis expressed protein 5, protein phosphatase 1 regulatory subunit 11, t-complex testis-expressed 5
Jones E, Kumanovics A, Yoshino M, Fischer Lindahl K. Mhc class I and non-class I gene organization in the proximal H2-M region of the mouse. Immunogenetics. 1999;49:183-95 pubmed
..mapped to a 180 kilobase interval in the distal part of the class I region in mouse, and their order Znf173-Rfb30-Tctex5-Tctex6- Tctex4-Mog was found conserved between human and mouse...
Han Y, Feng H, Cheung C, Lam P, Wang C, Haines C. Expression of a novel T-complex testis expressed 5 (Tctex5) in mouse testis, epididymis, and spermatozoa. Mol Reprod Dev. 2007;74:1132-40 pubmed
Expression of T-complex testis expressed 5 (Tctex5), an orthologue of protein phosphatase-1 inhibitor-3 (PPP1R11), was enhanced in mouse testis and was also expressed in epididymis and spermatozoa...
Zhang J, Zhang L, Zhao S, Lee E. Identification and characterization of the human HCG V gene product as a novel inhibitor of protein phosphatase-1. Biochemistry. 1998;37:16728-34 pubmed
..These characteristics are shared by the previously described protein phosphatase-1 inhibitor-2 and inhibitor-1 proteins. ..
Ha H, Howard C, Yeom Y, Abe K, Uehara H, Artzt K, et al
. Several testis-expressed genes in the mouse t-complex have expression differences between wild-type and t-mutant mice. Dev Genet. 1991;12:318-32 pubmed
..Interestingly, four Tctex genes show differences in the amount of transcript between wild-type and t-mutant testes. The chromosomal location and expression pattern imply that Tctex genes might be candidate genes for sterility or TRD. ..
Giffon T, Lepourcelet M, Pichon L, Jezequel P, Bouric P, Carn G, et al
. Cloning of a human homologue of the mouse Tctex-5 gene within the MHC class I region. Immunogenetics. 1996;44:331-9 pubmed
..Therefore we conclude that HCG V is unlikely to be involved in the pathogenesis of hemochromatosis. ..
Han Y, Song X, Feng H, Cheung C, Lam P, Wang C, et al
. Mutations of t-complex testis expressed gene 5 transcripts in the testis of sterile t-haplotype mutant mouse. Asian J Androl. 2008;10:219-26 pubmed publisher
To determine the possible roles of the t-complex testis expressed gene 5 (Tctex5) on sperm functions, the full-length sequence of mRNA was studied and compared in the testis between the normal wild-type and the sterile t-haplotype mutant ..
Cheng L, Pilder S, Nairn A, Ramdas S, Vijayaraghavan S. PP1gamma2 and PPP1R11 are parts of a multimeric complex in developing testicular germ cells in which their steady state levels are reciprocally related. PLoS ONE. 2009;4:e4861 pubmed publisher
..forms an inactive complex with actin, protein phosphatase 1 regulatory subunit 7 (PPP1R7), and protein phosphatase 1 regulatory subunit 11 (PPP1R11), the latter, a potent PP1 inhibitor...
McKelvey A, Lear T, Dunn S, Evankovich J, Londino J, Bednash J, et al
. RING finger E3 ligase PPP1R11 regulates TLR2 signaling and innate immunity. elife. 2016;5: pubmed publisher
..We show a new mechanism in which an uncharacterized RING finger E3 ligase, PPP1R11, directly ubiquitinates TLR2 both in vitro and in vivo, which leads to TLR2 degradation and disruption of the ..