Ppm1k

Summary

Gene Symbol: Ppm1k
Description: protein phosphatase 1K (PP2C domain containing)
Alias: 2900063A19Rik, A930026L03Rik, PP2Cm, PP2C-kappa, protein phosphatase 1K, mitochondrial, protein phosphatase 2C isoform kappa
Species: mouse

Top Publications

  1. pmc Tissue-specific and nutrient regulation of the branched-chain α-keto acid dehydrogenase phosphatase, protein phosphatase 2Cm (PP2Cm)
    Meiyi Zhou
    Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    J Biol Chem 287:23397-406. 2012
  2. pmc A novel mitochondrial matrix serine/threonine protein phosphatase regulates the mitochondria permeability transition pore and is essential for cellular survival and development
    Gang Lu
    Department of Anesthesiology, University of California at Los Angeles, Los Angeles, California 90095, USA
    Genes Dev 21:784-96. 2007
  3. pmc Protein phosphatase 2Cm is a critical regulator of branched-chain amino acid catabolism in mice and cultured cells
    Gang Lu
    Division of Molecular Medicine, Department of Anesthesiology, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA
    J Clin Invest 119:1678-87. 2009

Detail Information

Publications3

  1. pmc Tissue-specific and nutrient regulation of the branched-chain α-keto acid dehydrogenase phosphatase, protein phosphatase 2Cm (PP2Cm)
    Meiyi Zhou
    Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    J Biol Chem 287:23397-406. 2012
    ..Our previous study has identified a mitochondria-targeted protein phosphatase, PP2Cm, as the BCKD phosphatase and thus serves as a key regulator for BCAA catabolism...
  2. pmc A novel mitochondrial matrix serine/threonine protein phosphatase regulates the mitochondria permeability transition pore and is essential for cellular survival and development
    Gang Lu
    Department of Anesthesiology, University of California at Los Angeles, Los Angeles, California 90095, USA
    Genes Dev 21:784-96. 2007
    ..Here, we report the finding of a mitochondrial matrix-targeted protein phosphatase 2C family member (PP2Cm) that regulates mitochondrial membrane permeability transition pore (MPTP) opening and is essential for cell ..
  3. pmc Protein phosphatase 2Cm is a critical regulator of branched-chain amino acid catabolism in mice and cultured cells
    Gang Lu
    Division of Molecular Medicine, Department of Anesthesiology, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA
    J Clin Invest 119:1678-87. 2009
    ..Using unbiased, proteomic approaches, we have found that a mitochondrial-targeted phosphatase, PP2Cm, specifically binds the BCKD complex and induces dephosphorylation of Ser293 in the presence of BCKD substrates...