- A novel mitochondrial matrix serine/threonine protein phosphatase regulates the mitochondria permeability transition pore and is essential for cellular survival and developmentGang Lu
Department of Anesthesiology, University of California at Los Angeles, Los Angeles, California 90095, USA
Genes Dev 21:784-96. 2007..Here, we report the finding of a mitochondrial matrix-targeted protein phosphatase 2C family member (PP2Cm) that regulates mitochondrial membrane permeability transition pore (MPTP) opening and is essential for cell ..
- Protein phosphatase 2Cm is a critical regulator of branched-chain amino acid catabolism in mice and cultured cellsGang Lu
Division of Molecular Medicine, Department of Anesthesiology, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA
J Clin Invest 119:1678-87. 2009..Using unbiased, proteomic approaches, we have found that a mitochondrial-targeted phosphatase, PP2Cm, specifically binds the BCKD complex and induces dephosphorylation of Ser293 in the presence of BCKD substrates...