Gene Symbol: Ppib
Description: peptidylprolyl isomerase B
Alias: AA408962, AA553318, AI844835, Cphn-2, Cphn2, CyP-20b, peptidyl-prolyl cis-trans isomerase B, CYP-S1, PPIase B, S-cyclophilin, SCYLP, cyclophilin B, rotamase B
Species: mouse
Products:     Ppib

Top Publications

  1. Schumacher A, Schröter H, Multhaup G, Nordheim A. Murine cyclophilin-S1: a variant peptidyl-prolyl isomerase with a putative signal sequence expressed in differentiating F9 cells. Biochim Biophys Acta. 1991;1129:13-22 pubmed
    ..Specific subcellular localization of PPIases is postulated to contribute to functional specificities of this class of enzymes. ..
  2. Meunier L, Usherwood Y, Chung K, Hendershot L. A subset of chaperones and folding enzymes form multiprotein complexes in endoplasmic reticulum to bind nascent proteins. Mol Biol Cell. 2002;13:4456-69 pubmed
    ..BiP; GRP94; CaBP1; protein disulfide isomerase (PDI); ERdj3, a recently identified ER Hsp40 cochaperone; cyclophilin B; ERp72; GRP170; UDP-glucosyltransferase; and SDF2-L1...
  3. Choi J, Sutor S, Lindquist L, Evans G, Madden B, Bergen H, et al. Severe osteogenesis imperfecta in cyclophilin B-deficient mice. PLoS Genet. 2009;5:e1000750 pubmed publisher
    ..P3H1 exists in a complex with CRTAP and the peptidyl-prolyl isomerase cyclophilin B (CypB), encoded by the Ppib gene...
  4. Terajima M, Taga Y, Chen Y, Cabral W, Hou Fu G, Srisawasdi S, et al. Cyclophilin-B Modulates Collagen Cross-linking by Differentially Affecting Lysine Hydroxylation in the Helical and Telopeptidyl Domains of Tendon Type I Collagen. J Biol Chem. 2016;291:9501-12 pubmed publisher
    ..A recent study on cyclophilin B (CypB) null mice, a model of recessive osteogenesis imperfecta, demonstrated that lysine hydroxylation at the ..
  5. Ben Gedalya T, Moll L, Bejerano Sagie M, Frere S, Cabral W, Friedmann Morvinski D, et al. Alzheimer's disease-causing proline substitutions lead to presenilin 1 aggregation and malfunction. EMBO J. 2015;34:2820-39 pubmed publisher
    ..These substitutions were found to prevent the endoplasmic reticulum (ER)-resident chaperone, cyclophilin B, from assisting presenilin 1 to fold properly, leading to its aggregation, deposition in the ER, reduction of √..
  6. Cabral W, Perdivara I, Weis M, Terajima M, Blissett A, Chang W, et al. Abnormal type I collagen post-translational modification and crosslinking in a cyclophilin B KO mouse model of recessive osteogenesis imperfecta. PLoS Genet. 2014;10:e1004465 pubmed publisher
    b>Cyclophilin B (CyPB), encoded by PPIB, is an ER-resident peptidyl-prolyl cis-trans isomerase (PPIase) that functions independently and as a component of the collagen prolyl 3-hydroxylation complex...
  7. Balsley M, Malesevic M, Stemmy E, Gigley J, Jurjus R, Herzog D, et al. A cell-impermeable cyclosporine A derivative reduces pathology in a mouse model of allergic lung inflammation. J Immunol. 2010;185:7663-70 pubmed publisher
  8. Lane Guermonprez L, Morot Gaudry Talarmain Y, Meunier F, O Regan S, Onofri F, Le Caer J, et al. Synapsin associates with cyclophilin B in an ATP- and cyclosporin A-dependent manner. J Neurochem. 2005;93:1401-11 pubmed
    ..vesicle-associated protein, can be purified from Torpedo cholinergic synaptosomes through its affinity to cyclophilin B, an immunophilin that is particularly abundant in brain...
  9. Dioum E, Chen R, Alexander M, Zhang Q, Hogg R, Gerard R, et al. Regulation of hypoxia-inducible factor 2alpha signaling by the stress-responsive deacetylase sirtuin 1. Science. 2009;324:1289-93 pubmed publisher
    ..Thus, Sirt1 promotes HIF-2 signaling during hypoxia and likely other environmental stresses. ..

Scientific Experts

More Information


  1. Hasel K, Glass J, Godbout M, Sutcliffe J. An endoplasmic reticulum-specific cyclophilin. Mol Cell Biol. 1991;11:3484-91 pubmed
    ..These results suggest that cyclosporin A mediates its effect on cells through more than one cyclophilin and that cyclosporin A-induced misfolding of T-cell membrane proteins normally mediated by CPH2 plays a role in immunosuppression. ..
  2. Weissman I, Friedman J, Alpert S. An analysis of the expression of cyclophilin C reveals tissue restriction and an intriguing pattern in the mouse kidney. Am J Pathol. 1994;144:1247-56 pubmed
    ..The S3 segment has been shown to sustain histopathological damage from high dosages of CsA, raising the possibility that cyp C may be involved in mediating this damage. ..
  3. Walsh C, Zydowsky L, McKeon F. Cyclosporin A, the cyclophilin class of peptidylprolyl isomerases, and blockade of T cell signal transduction. J Biol Chem. 1992;267:13115-8 pubmed
    ..The molecular insights gained over a short time in this area have been remarkable; they promise to elucidate the steps in T cell activation and delineate new targets for immunosuppressive therapy. ..
  4. Ortsäter H, Sundsten T, Lin J, Bergsten P. Evaluation of the SELDI-TOF MS technique for protein profiling of pancreatic islets exposed to glucose and oleate. Proteomics. 2007;7:3105-15 pubmed
    ..In conclusion, the study demonstrates that SELDI-technique can be used not only to obtain islet protein patterns but is also helpful in the subsequent identification of differentially expressed proteins. ..
  5. Hershko K, Simhadri V, Blaisdell A, Hunt R, Newell J, Tseng S, et al. Cyclosporin A impairs the secretion and activity of ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 repeat). J Biol Chem. 2012;287:44361-71 pubmed publisher
    ..Until now, the reason for such a link was unclear. Here we provide evidence demonstrating that cyclophilin B (CypB) activity plays an important role in the secretion of active ADAMTS13...
  6. Heard M, Besio R, Weis M, Rai J, Hudson D, Dimori M, et al. Sc65-Null Mice Provide Evidence for a Novel Endoplasmic Reticulum Complex Regulating Collagen Lysyl Hydroxylation. PLoS Genet. 2016;12:e1006002 pubmed publisher
    ..complex affects the activity of lysyl-hydroxylase 1 potentially through interactions with the enzyme and/or cyclophilin B. Loss of Sc65 in the mouse results in instability of this complex, altered collagen lysine hydroxylation and ..
  7. Eickhoff H, Schuchhardt J, Ivanov I, Meier Ewert S, O Brien J, Malik A, et al. Tissue gene expression analysis using arrayed normalized cDNA libraries. Genome Res. 2000;10:1230-40 pubmed
    ..The obtained results are publicly available (http://www.rzpd.de) and can be used by other researchers as a digital expression reference. ..
  8. Galat A. Variations of sequences and amino acid compositions of proteins that sustain their biological functions: An analysis of the cyclophilin family of proteins. Arch Biochem Biophys. 1999;371:149-62 pubmed
  9. Ishikawa Y, Bachinger H. An additional function of the rough endoplasmic reticulum protein complex prolyl 3-hydroxylase 1·cartilage-associated protein·cyclophilin B: the CXXXC motif reveals disulfide isomerase activity in vitro. J Biol Chem. 2013;288:31437-46 pubmed publisher
    ..Prolyl 3-hydroxylase 1 (P3H1) forms a hetero-trimeric complex with cartilage-associated protein and cyclophilin B (CypB)...
  10. Kanaki T, Bujo H, Hirayama S, Tanaka K, Yamazaki H, Seimiya K, et al. Developmental regulation of LR11 expression in murine brain. DNA Cell Biol. 1998;17:647-57 pubmed
    ..In addition, detailed knowledge of LR11 biology will help to elucidate the roles of other mosaic proteins that share with LR11 elements whose function is not yet known. ..
  11. Snowball J, Ambalavanan M, Whitsett J, Sinner D. Endodermal Wnt signaling is required for tracheal cartilage formation. Dev Biol. 2015;405:56-70 pubmed publisher
    ..In conclusion, Wnt ligands produced by the tracheal epithelium pattern the tracheal mesenchyme via modulation of gene expression and cell proliferation required for proper tracheal cartilage and smooth muscle differentiation. ..
  12. Himmels P, Paredes I, Adler H, Karakatsani A, Luck R, Marti H, et al. Motor neurons control blood vessel patterning in the developing spinal cord. Nat Commun. 2017;8:14583 pubmed publisher