Gene Symbol: Ppia
Description: peptidylprolyl isomerase A
Alias: 2700098C05, Cphn, CyP-18, CypA, peptidyl-prolyl cis-trans isomerase A, PPIase A, SP18, cyclophilin A, cyclosporin A-binding protein, rotamase A
Species: mouse
Products:     Ppia

Top Publications

  1. Satoh K, Matoba T, Suzuki J, O Dell M, Nigro P, Cui Z, et al. Cyclophilin A mediates vascular remodeling by promoting inflammation and vascular smooth muscle cell proliferation. Circulation. 2008;117:3088-98 pubmed publisher
    Oxidative stress, generated by excessive reactive oxygen species, promotes cardiovascular disease. Cyclophilin A (CyPA) is a 20-kDa chaperone protein secreted from vascular smooth muscle cells (VSMCs) in response to reactive oxygen ..
  2. Colgan J, Asmal M, Neagu M, Yu B, Schneidkraut J, Lee Y, et al. Cyclophilin A regulates TCR signal strength in CD4+ T cells via a proline-directed conformational switch in Itk. Immunity. 2004;21:189-201 pubmed
    b>Cyclophilin A (CypA/Ppia) is a peptidyl-prolyl isomerase (PPIase) that binds the immunosuppressive drug cyclosporine. The resulting complex blocks T cell function by inhibiting the calcium-dependent phosphatase calcineurin...
  3. Jin Z, Lungu A, Xie L, Wang M, Wong C, Berk B. Cyclophilin A is a proinflammatory cytokine that activates endothelial cells. Arterioscler Thromb Vasc Biol. 2004;24:1186-91 pubmed
    b>Cyclophilin A (CyPA) is an abundant intracellular protein that is considered to be the main target of the immunosuppressive drug cyclosporine A...
  4. Satoh K, Nigro P, Zeidan A, Soe N, Jaffré F, Oikawa M, et al. Cyclophilin A promotes cardiac hypertrophy in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol. 2011;31:1116-23 pubmed publisher
    b>Cyclophilin A (CyPA, encoded by Ppia) is a proinflammatory protein secreted in response to oxidative stress in mice and humans...
  5. Khromykh L, Kulikova N, Anfalova T, Muranova T, Abramov V, Vasiliev A, et al. Cyclophilin A produced by thymocytes regulates the migration of murine bone marrow cells. Cell Immunol. 2007;249:46-53 pubmed
    ..of the 18 kDa protein, whose amino acid sequence fits with the sequence of the secretory form of murine cyclophilin A (SP-18)...
  6. Zhu C, Wang X, Deinum J, Huang Z, Gao J, Modjtahedi N, et al. Cyclophilin A participates in the nuclear translocation of apoptosis-inducing factor in neurons after cerebral hypoxia-ischemia. J Exp Med. 2007;204:1741-8 pubmed
    ..Garrido, et al. 2004. Oncogene. 23:1514-1521) performed in vitro suggests that AIF must interact with cyclophilin A (CypA) to form a proapoptotic DNA degradation complex...
  7. Sherry B, Yarlett N, Strupp A, Cerami A. Identification of cyclophilin as a proinflammatory secretory product of lipopolysaccharide-activated macrophages. Proc Natl Acad Sci U S A. 1992;89:3511-5 pubmed
    We have isolated an 18-kDa peptide (designated sp18, for 18-kDa secreted protein) from the conditioned medium of lipopolysaccharide-stimulated RAW 264.7 murine macrophages...
  8. Colgan J, Asmal M, Yu B, Luban J. Cyclophilin A-deficient mice are resistant to immunosuppression by cyclosporine. J Immunol. 2005;174:6030-8 pubmed
    ..of cyclosporine on immune cells and mice lacking Ppia, the gene encoding the prototypical cyclophilin protein cyclophilin A. TCR-induced proliferation and signal transduction by Ppia(-/-) CD4(+) T cells were resistant to cyclosporine, ..
  9. Nigro P, Satoh K, O Dell M, Soe N, Cui Z, Mohan A, et al. Cyclophilin A is an inflammatory mediator that promotes atherosclerosis in apolipoprotein E-deficient mice. J Exp Med. 2011;208:53-66 pubmed publisher
    b>Cyclophilin A (CyPA; encoded by Ppia) is a ubiquitously expressed protein secreted in response to inflammatory stimuli...

More Information


  1. Handschumacher R, Harding M, Rice J, Drugge R, Speicher D. Cyclophilin: a specific cytosolic binding protein for cyclosporin A. Science. 1984;226:544-7 pubmed
    ..Isolation of cyclophilin from the cytosol of thymocytes suggests that the immunosuppressive activity of cyclosporin A is mediated by an intracellular mechanism, not by a membrane-associated mechanism. ..
  2. Colgan J, Asmal M, Luban J. Isolation, characterization and targeted disruption of mouse ppia: cyclophilin A is not essential for mammalian cell viability. Genomics. 2000;68:167-78 pubmed
    ..The founding member of the family, cyclophilin A (CyPA), is an abundant, ubiquitously expressed protein of unknown function that binds with nanomolar affinity ..
  3. Satoh K, Nigro P, Matoba T, O Dell M, Cui Z, Shi X, et al. Cyclophilin A enhances vascular oxidative stress and the development of angiotensin II-induced aortic aneurysms. Nat Med. 2009;15:649-56 pubmed publisher
    ..b>Cyclophilin A (CypA, encoded by Ppia) is highly expressed in vascular smooth muscle cells (VSMCs), is secreted in response ..
  4. Seizer P, Schonberger T, Schött M, Lang M, Langer H, Bigalke B, et al. EMMPRIN and its ligand cyclophilin A regulate MT1-MMP, MMP-9 and M-CSF during foam cell formation. Atherosclerosis. 2010;209:51-7 pubmed publisher
    ..Thus, we investigated the role of EMMPRIN (CD147) and its ligand cyclophilin A (CyPA) during foam cell formation originating from both monocytes/macrophages and CD34(+) progenitor cells...
  5. Galigniana M, Morishima Y, Gallay P, Pratt W. Cyclophilin-A is bound through its peptidylprolyl isomerase domain to the cytoplasmic dynein motor protein complex. J Biol Chem. 2004;279:55754-9 pubmed
    Although cyclophilin A (CyP-A) is a relatively abundant small immunophilin present in the cytoplasm of all mammalian cells, its general function(s) in the absence of the immunosuppressant drug cyclosporin A is not known...
  6. Song J, Lu Y, Yokoyama K, Rossi J, Chiu R. Cyclophilin A is required for retinoic acid-induced neuronal differentiation in p19 cells. J Biol Chem. 2004;279:24414-9 pubmed
    Stable transfectants with expression of small interfering RNA for targeting cyclophilin A (CypA) in p19 cells lose their potential for retinoic acid (RA)-induced neuronal differentiation but not Me(2)SO-induced mesodermal differentiation...
  7. Fischer G, Wittmann Liebold B, Lang K, Kiefhaber T, Schmid F. Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably identical proteins. Nature. 1989;337:476-8 pubmed
    ..The activities of both PPIase and cyclophilin depend on a single sulphydryl group. At present it is unknown whether the inhibition of prolyl isomerase activity is related with the immunosuppressive action of CsA. ..
  8. Li B, Lee K, Martin R. Overexpression of glucose transporter 2 in GT1-7 cells inhibits AMP-activated protein kinase and agouti-related peptide expression. Brain Res. 2006;1118:1-5 pubmed
  9. Berger J, Truppe C, Neumann H, Forss Petter S. cDNA cloning and mRNA distribution of a mouse very long-chain acyl-CoA synthetase. FEBS Lett. 1998;425:305-9 pubmed
  10. Raji B, Dansault A, Leemput J, de la Houssaye G, Vieira V, Kobetz A, et al. The RNA-binding protein Musashi-1 is produced in the developing and adult mouse eye. Mol Vis. 2007;13:1412-27 pubmed
  11. Takasaki N, McIsaac R, Dean J. Gpbox (Psx2), a homeobox gene preferentially expressed in female germ cells at the onset of sexual dimorphism in mice. Dev Biol. 2000;223:181-93 pubmed
    ..The persistence of GPBOX transcripts in female germ cells until E15.5 and their virtual disappearance in males by E13.5 suggest that Gpbox may play a role in mammalian oogenesis. ..
  12. Basu P, Lung T, Lemsaddek W, Sargent T, Williams D, Basu M, et al. EKLF and KLF2 have compensatory roles in embryonic beta-globin gene expression and primitive erythropoiesis. Blood. 2007;110:3417-25 pubmed
    ..The data indicate that EKLF and KLF2 have redundant functions in embryonic beta-like globin gene expression, primitive erythropoiesis, and endothelial development. ..
  13. Malin D, Kim I, Boetticher E, Kalin T, Ramakrishna S, Meliton L, et al. Forkhead box F1 is essential for migration of mesenchymal cells and directly induces integrin-beta3 expression. Mol Cell Biol. 2007;27:2486-98 pubmed
    ..Foxf1 plays an essential role in mesenchyme migration by transcriptionally regulating Itgbeta3. ..
  14. Agrawal M, Bowman L. Transcriptional and translational regulation of ribosomal protein formation during mouse myoblast differentiation. J Biol Chem. 1987;262:4868-75 pubmed
    ..Thus, the production of r-proteins is regulated both at the level of transcription and translation during mouse myoblast differentiation. ..
  15. Rouvinski A, Gahali Sass I, Stav I, Metzer E, Atlan H, Taraboulos A. Both raft- and non-raft proteins associate with CHAPS-insoluble complexes: some APP in large complexes. Biochem Biophys Res Commun. 2003;308:750-8 pubmed
    ..Large CHAPS-insoluble complexes resemble, but are not equal to, classical rafts. These findings extend considerably the range of detergent-insoluble membranal domains. ..
  16. Seizer P, Ochmann C, Schonberger T, Zach S, Rose M, Borst O, et al. Disrupting the EMMPRIN (CD147)-cyclophilin A interaction reduces infarct size and preserves systolic function after myocardial ischemia and reperfusion. Arterioscler Thromb Vasc Biol. 2011;31:1377-86 pubmed publisher
    ..The extracellular matrix metalloproteinase inducer EMMPRIN (CD147) and its ligand cyclophilin A (CyPA) may be involved in both processes...
  17. Hadsell D, Bonnette S, George J, Torres D, Klimentidis Y, Klementidis Y, et al. Diminished milk synthesis in upstream stimulatory factor 2 null mice is associated with decreased circulating oxytocin and decreased mammary gland expression of eukaryotic initiation factors 4E and 4G. Mol Endocrinol. 2003;17:2251-67 pubmed
  18. Theodor L, Peleg D, Meyuhas O. P31, a mammalian housekeeping protein encoded by a multigene family containing a high proportion of pseudogenes. Biochim Biophys Acta. 1985;826:137-46 pubmed
    ..Although the features of the mRNA and the genes encoding P31 exhibit extensive similarity with those of ribosomal proteins, neither the identity nor the biological function of the protein has yet been determined. ..
  19. Fitzpatrick G, Soloway P, Higgins M. Regional loss of imprinting and growth deficiency in mice with a targeted deletion of KvDMR1. Nat Genet. 2002;32:426-31 pubmed
    ..These findings support the hypothesis that loss of methylation in BWS patients activates the repressive function of KvDMR1 on the maternal chromosome, resulting in abnormal silencing of CDKN1C and the development of BWS. ..
  20. Pasetto L, Pozzi S, Castelnovo M, Basso M, ESTEVEZ A, Fumagalli S, et al. Targeting Extracellular Cyclophilin A Reduces Neuroinflammation and Extends Survival in a Mouse Model of Amyotrophic Lateral Sclerosis. J Neurosci. 2017;37:1413-1427 pubmed publisher
    ..b>Cyclophilin A, also known as peptidylprolyl cis-/trans-isomerase A (PPIA), as a foldase is beneficial intracellularly, but ..
  21. Lauren J, Airaksinen M, Saarma M, Timmusk T. Two novel mammalian Nogo receptor homologs differentially expressed in the central and peripheral nervous systems. Mol Cell Neurosci. 2003;24:581-94 pubmed
    ..We also show that all four members of the reticulon family, including Nogo-A, are widely expressed in the nervous system, and therefore are possible ligands for the NgRLs. ..
  22. Varmuza S, Tate P. Isolation of epiblast-specific cDNA clones by differential hybridization with polymerase chain reaction-amplified probes derived from single embryos. Mol Reprod Dev. 1992;32:339-48 pubmed
    ..This approach may prove useful for identifying genes that play a role during development. ..
  23. Dagnino L, Fry C, Bartley S, Farnham P, Gallie B, Phillips R. Expression patterns of the E2F family of transcription factors during murine epithelial development. Cell Growth Differ. 1997;8:553-63 pubmed
    ..Thus, selective regulation of E2F forms occurs during murine epithelial development, irrespective of the ectodermal or endodermal origin of such epithelia. ..
  24. Seizer P, Ungern Sternberg S, Schönberger T, Borst O, Münzer P, Schmidt E, et al. Extracellular cyclophilin A activates platelets via EMMPRIN (CD147) and PI3K/Akt signaling, which promotes platelet adhesion and thrombus formation in vitro and in vivo. Arterioscler Thromb Vasc Biol. 2015;35:655-63 pubmed publisher
    b>Cyclophilin A (CyPA) is secreted under inflammatory conditions by various cell types...
  25. Bell R, Winkler E, Singh I, Sagare A, Deane R, Wu Z, et al. Apolipoprotein E controls cerebrovascular integrity via cyclophilin A. Nature. 2012;485:512-6 pubmed publisher
    ..Using different APOE transgenic mice, including mice with ablation and/or inhibition of cyclophilin A (CypA), here we show that expression of APOE4 and lack of murine Apoe, but not APOE2 and APOE3, leads to BBB ..
  26. Rezzani R, Favero G, Stacchiotti A, Rodella L. Endothelial and vascular smooth muscle cell dysfunction mediated by cyclophylin A and the atheroprotective effects of melatonin. Life Sci. 2013;92:875-82 pubmed publisher
    This study evaluated the role of cyclophilin A (CyPA) in early phase of atherosclerosis and also examined the atheroprotective effects of melatonin due to its antioxidant properties...
  27. Lindholm P, Peranen J, Andressoo J, Kalkkinen N, Kokaia Z, Lindvall O, et al. MANF is widely expressed in mammalian tissues and differently regulated after ischemic and epileptic insults in rodent brain. Mol Cell Neurosci. 2008;39:356-71 pubmed publisher
    ..The widespread expression of MANF together with its evolutionary conserved nature and regulation by brain insults suggest that it has important functions both under normal and pathological conditions in many tissue types. ..
  28. Joyner N, Smoak I. In vivo hyperglycemia and its effect on Glut-1 expression in the embryonic heart. Birth Defects Res A Clin Mol Teratol. 2004;70:438-48 pubmed
    ..Hyperglycemia-induced alterations in Glut-1 expression likely interfere with balance of glucose available to the embryonic heart that may affect cardiac morphogenesis. ..
  29. Vosseller K, Hansen K, Chalkley R, Trinidad J, Wells L, Hart G, et al. Quantitative analysis of both protein expression and serine / threonine post-translational modifications through stable isotope labeling with dithiothreitol. Proteomics. 2005;5:388-98 pubmed
    ..These results demonstate BEMAD is suitable for large-scale quantitative analysis of both protein expression and serine / threonine post-translational modifications. ..
  30. Chatterjee M, Seizer P, Borst O, Schonberger T, Mack A, Geisler T, et al. SDF-1? induces differential trafficking of CXCR4-CXCR7 involving cyclophilin A, CXCR7 ubiquitination and promotes platelet survival. FASEB J. 2014;28:2864-78 pubmed publisher
    ..Schönberger, T., Mack, A., Geisler, T., Langer, H. F., May, A. E., Vogel, S., Lang, F., Gawaz, M. SDF-1? induces differential trafficking of CXCR4-CXCR7 involving cyclophilin A, CXCR7 ubiquitination and promotes platelet survival.
  31. Yan J, Li Y, Wang Z, Liang Y, Yuan W, Wang C. Effects of OX40-OX40 ligand interaction on the levels of ROS and Cyclophilin A in C57BL/6J mice atherogenesis. Int J Cardiol. 2014;176:405-12 pubmed publisher
    ..of OX40-OX40L interaction on the levels of intracellular reactive oxygen species (ROS) and the secretion of Cyclophilin A (CyPA) in C57BL/6J mice atherogenesis...
  32. Jokela H, Rantakari P, Lamminen T, Strauss L, Ola R, Mutka A, et al. Hydroxysteroid (17beta) dehydrogenase 7 activity is essential for fetal de novo cholesterol synthesis and for neuroectodermal survival and cardiovascular differentiation in early mouse embryos. Endocrinology. 2010;151:1884-92 pubmed publisher
    ..The septum of the atrium was also defected in the knockout mice. ..
  33. Urano Y, Iiduka M, Sugiyama A, Akiyama H, Uzawa K, Matsumoto G, et al. Involvement of the mouse Prp19 gene in neuronal/astroglial cell fate decisions. J Biol Chem. 2006;281:7498-514 pubmed
    ..Based on yeast two-hybrid screening, cyclophilin A was identified as a specific binding partner of the beta-variant...
  34. Matsui T, Hayashi Kisumi F, Kinoshita Y, Katahira S, Morita K, Miyachi Y, et al. Identification of novel keratinocyte-secreted peptides dermokine-alpha/-beta and a new stratified epithelium-secreted protein gene complex on human chromosome 19q13.1. Genomics. 2004;84:384-97 pubmed
    ..These findings indicated that dermokine-alpha/-beta, suprabasin, and Kdap are secreted from the spinous layer of the stratified epithelia and that these genes form a novel gene complex on the chromosome. ..
  35. He H, Mou Z, Li W, Fei L, Tang Y, Zhang J, et al. Proteomic methods reveal cyclophilin A function as a host restriction factor against rotavirus infection. Proteomics. 2013;13:1121-32 pubmed publisher
    ..b>Cyclophilin A (CYPA), a peptidyl-prolyl cis-trans isomerase, was among these upregulated host proteins...
  36. Takapoo M, Chamseddine A, Bhalla R, Miller F. Glutathione peroxidase-deficient smooth muscle cells cause paracrine activation of normal smooth muscle cells via cyclophilin A. Vascul Pharmacol. 2011;55:143-8 pubmed publisher
    ..In response to oxidative stress, smooth muscle cells (SMCs) secrete the pro-inflammatory immunomodulator cyclophilin A (CyPA)...
  37. Pang C, Lemsaddek W, Alhashem Y, Bondzi C, Redmond L, Ah Son N, et al. Kruppel-like factor 1 (KLF1), KLF2, and Myc control a regulatory network essential for embryonic erythropoiesis. Mol Cell Biol. 2012;32:2628-44 pubmed publisher
    ..5 and E11.5. This study reveals a novel regulatory network by which KLF1 and KLF2 regulate Myc to control the primitive erythropoietic program. ..
  38. Soe N, Sowden M, Baskaran P, Kim Y, Nigro P, Smolock E, et al. Acetylation of cyclophilin A is required for its secretion and vascular cell activation. Cardiovasc Res. 2014;101:444-53 pubmed publisher
    b>Cyclophilin A (CyPA) is a pro-inflammatory mediator involved in oxidative stress-related cardiovascular diseases...
  39. Xue C, Sowden M, Berk B. Extracellular Cyclophilin A, Especially Acetylated, Causes Pulmonary Hypertension by Stimulating Endothelial Apoptosis, Redox Stress, and Inflammation. Arterioscler Thromb Vasc Biol. 2017;37:1138-1146 pubmed publisher
    Oxidative stress and inflammation play key roles in the development of pulmonary arterial hypertension (PAH). Cyclophilin A (CypA) is secreted in response to oxidative stress and promotes inflammation and cardiovascular disease...
  40. McClatchie T, Meredith M, Ouédraogo M, Slow S, Lever M, Mann M, et al. Betaine is accumulated via transient choline dehydrogenase activation during mouse oocyte meiotic maturation. J Biol Chem. 2017;292:13784-13794 pubmed publisher
    ..Overall, betaine accumulation is a previously unsuspected physiological process during mouse oocyte meiotic maturation whose underlying mechanism is the transient activation of CHDH. ..
  41. Kawasaki H, Mocarski E, Kosugi I, Tsutsui Y. Cyclosporine inhibits mouse cytomegalovirus infection via a cyclophilin-dependent pathway specifically in neural stem/progenitor cells. J Virol. 2007;81:9013-23 pubmed
    ..Finally, inhibition of endogenous CyP A (CyPA) by small interfering RNA also inhibited replication in NSPCs...
  42. Takahashi N, Hayano T, Suzuki M. Peptidyl-prolyl cis-trans isomerase is the cyclosporin A-binding protein cyclophilin. Nature. 1989;337:473-5 pubmed
    ..Thus we propose that the peptidyl-prolyl cis-trans isomerizing activity of PPIase may be involved in events, such as those occurring early in T-cell activation, that are suppressed by cyclosporin A. ..
  43. Li Y, Wu H, Weng C, Chen Y, Hung C, Yang C, et al. Cyclophilin A and nuclear factor of activated T cells are essential in cyclosporine-mediated suppression of polyomavirus BK replication. Am J Transplant. 2012;12:2348-62 pubmed publisher
    ..We previously demonstrated that cyclosporin A (CsA) suppressed polyomavirus BK (BKV) replication. The role of cyclophilin A (CypA) and nuclear factor of activated T cells (NFAT) in CsA-imposed suppression of BKV replication was ..
  44. Walsh C, Zydowsky L, McKeon F. Cyclosporin A, the cyclophilin class of peptidylprolyl isomerases, and blockade of T cell signal transduction. J Biol Chem. 1992;267:13115-8 pubmed
    ..The molecular insights gained over a short time in this area have been remarkable; they promise to elucidate the steps in T cell activation and delineate new targets for immunosuppressive therapy. ..
  45. Li Y, Yan J, Wu C, Wang Z, Yuan W, Wang D. CD137-CD137L interaction regulates atherosclerosis via cyclophilin A in apolipoprotein E-deficient mice. PLoS ONE. 2014;9:e88563 pubmed publisher
    Our previous studies showed that increased levels of cyclophilin A (CyPA) may be a valuable marker for predicting the severity of acute coronary syndromes and that interruption of CD137-CD137L interactions diminished the formation and ..
  46. Weissman I, Friedman J, Alpert S. An analysis of the expression of cyclophilin C reveals tissue restriction and an intriguing pattern in the mouse kidney. Am J Pathol. 1994;144:1247-56 pubmed
    ..The S3 segment has been shown to sustain histopathological damage from high dosages of CsA, raising the possibility that cyp C may be involved in mediating this damage. ..
  47. Kawamura Y, Uchijima Y, Horike N, Tonami K, Nishiyama K, Amano T, et al. Sirt3 protects in vitro-fertilized mouse preimplantation embryos against oxidative stress-induced p53-mediated developmental arrest. J Clin Invest. 2010;120:2817-28 pubmed publisher
    ..These results indicate that Sirt3 plays a protective role in preimplantation embryos against stress conditions during in vitro fertilization and culture...
  48. Suárez A, van Dyk L. Endothelial cells support persistent gammaherpesvirus 68 infection. PLoS Pathog. 2008;4:e1000152 pubmed publisher
  49. Fan L, Douglas G, Bendall J, McNeill E, Crabtree M, Hale A, et al. Endothelial cell-specific reactive oxygen species production increases susceptibility to aortic dissection. Circulation. 2014;129:2661-72 pubmed publisher
    ..Erk1/2 phosphorylation in vascular smooth muscle cells compared with wild-type controls through secreted cyclophilin A (CypA)...
  50. Kim S, Lessner S, Sakurai Y, Galis Z. Cyclophilin A as a novel biphasic mediator of endothelial activation and dysfunction. Am J Pathol. 2004;164:1567-74 pubmed
    ..We found that stimulation of human umbilical vein ECs with lipopolysaccharide induced secretion of cyclophilin (CyPA) an intracellular protein belonging to the immunophilin family...
  51. Seizer P, Klingel K, Sauter M, Westermann D, Ochmann C, Schonberger T, et al. Cyclophilin A affects inflammation, virus elimination and myocardial fibrosis in coxsackievirus B3-induced myocarditis. J Mol Cell Cardiol. 2012;53:6-14 pubmed publisher
    Extracellular cyclophilin A (CyPA) and its receptor Extracellular Matrix Metalloproteinase Inducer (EMMPRIN, CD147) modulate inflammatory processes beyond metalloproteinase (MMP) activity...
  52. Dorner M, Horwitz J, Donovan B, Labitt R, Budell W, Friling T, et al. Completion of the entire hepatitis C virus life cycle in genetically humanized mice. Nature. 2013;501:237-41 pubmed publisher
    ..In mice lacking the essential cellular co-factor cyclophilin A (CypA), HCV RNA replication is markedly diminished, providing genetic evidence that this process is faithfully ..
  53. Soe N, Sowden M, Baskaran P, Smolock E, Kim Y, Nigro P, et al. Cyclophilin A is required for angiotensin II-induced p47phox translocation to caveolae in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 2013;33:2147-53 pubmed publisher
    ..b>Cyclophilin A (CyPA) is a ubiquitously expressed cytosolic protein that possesses peptidyl-prolyl cis-trans isomerase ..
  54. Kim I, Ramakrishna S, Gusarova G, Yoder H, Costa R, Kalinichenko V. The forkhead box m1 transcription factor is essential for embryonic development of pulmonary vasculature. J Biol Chem. 2005;280:22278-86 pubmed
    ..In summary, development of mouse lungs depends on the Foxm1 transcription factor, which regulates expression of genes essential for mesenchyme proliferation, extracellular matrix remodeling, and vasculogenesis. ..
  55. Spears N, Molinek M, Robinson L, Fulton N, Cameron H, Shimoda K, et al. The role of neurotrophin receptors in female germ-cell survival in mouse and human. Development. 2003;130:5481-91 pubmed
    ..The results indicate that signalling through TrkB is an important component of the mechanism that regulates the early survival of female germ cells. ..
  56. Galat A. Variations of sequences and amino acid compositions of proteins that sustain their biological functions: An analysis of the cyclophilin family of proteins. Arch Biochem Biophys. 1999;371:149-62 pubmed
  57. Dear J, Simpson K, Nicolai M, Catterson J, Street J, Huizinga T, et al. Cyclophilin A is a damage-associated molecular pattern molecule that mediates acetaminophen-induced liver injury. J Immunol. 2011;187:3347-52 pubmed publisher
    ..b>Cyclophilin A (CypA) is an intracellular protein that is proinflammatory when released by cells...
  58. Biben C, Stanley E, Fabri L, Kotecha S, Rhinn M, Drinkwater C, et al. Murine cerberus homologue mCer-1: a candidate anterior patterning molecule. Dev Biol. 1998;194:135-51 pubmed
    ..The data suggest that mCer-1 shares structural, functional, and expression characteristics with Xcer and may participate in patterning the anterior of the embryo and nascent somite region, in part, through a BMP-inhibitory mechanism. ..
  59. Lauren J, Airaksinen M, Saarma M, Timmusk T. A novel gene family encoding leucine-rich repeat transmembrane proteins differentially expressed in the nervous system. Genomics. 2003;81:411-21 pubmed
    ..The structure and expression profile of LRRTM mRNAs suggest that they may have a role in the development and maintenance of the vertebrate nervous system. ..
  60. Hasel K, Sutcliffe J. Nucleotide sequence of a cDNA coding for mouse cyclophilin. Nucleic Acids Res. 1990;18:4019 pubmed
  61. Su Z, Lin R, Chen Y, Shu X, Zhang H, Liang S, et al. Oxidized Low-Density Lipoprotein-Induced Cyclophilin A Secretion Requires ROCK-Dependent Diphosphorylation of Myosin Light Chain. J Vasc Res. 2016;53:206-215 pubmed
    Accumulation of cyclophilin A (CyPA) within atherosclerotic lesions is thought to be implicated in the progression of atherosclerosis. However, the source of CyPA within atherosclerotic lesions is still unknown...
  62. Sun S, Guo M, Zhang J, Ha A, Yokoyama K, CHIU R. Cyclophilin A (CypA) interacts with NF-κB subunit, p65/RelA, and contributes to NF-κB activation signaling. PLoS ONE. 2014;9:e96211 pubmed publisher
    Peptidyl-prolyl isomerase cyclophilin A (CypA) plays important roles in signaling, protein translocation, inflammation, and cancer formation. However, little is known about the mechanisms by which CypA exerts its effects...
  63. Römer I, Jungblut P, Reik W, Otto A, Klose J. A novel strategy to identify maternal and paternal inheritance in the mouse. Electrophoresis. 1995;16:823-30 pubmed
    ..For the beta-group hemoglobins our results suggested parental effects on the transcriptional level. ..
  64. Lin X, Shah S, Bulleit R. The expression of MEF2 genes is implicated in CNS neuronal differentiation. Brain Res Mol Brain Res. 1996;42:307-16 pubmed
    ..These observations suggest that MEF2 molecules may be an important factor involved in CNS neuron differentiation similar to their role in muscle differentiation. ..
  65. Krummrei U, Bang R, Schmidtchen R, Brune K, Bang H. Cyclophilin-A is a zinc-dependent DNA binding protein in macrophages. FEBS Lett. 1995;371:47-51 pubmed
    ..Immunofluorescence microscopy of mouse macrophages cell line with a monoclonal antibody mAb7F1 raised against CypA shows a co-localisation of CypA in the nucleus and in the cytosol...
  66. Guo M, James A, Kwak J, Shen J, Yokoyama K, Ting K, et al. Cyclophilin A (CypA) Plays Dual Roles in Regulation of Bone Anabolism and Resorption. Sci Rep. 2016;6:22378 pubmed publisher
    CypA (Cyclophilin A) is a peptidyl-prolyl isomerase previously shown to be required for chondrogenic differentiation and endochondral ossification...
  67. Elvers M, Herrmann A, Seizer P, Münzer P, Beck S, Schonberger T, et al. Intracellular cyclophilin A is an important Ca(2+) regulator in platelets and critically involved in arterial thrombus formation. Blood. 2012;120:1317-26 pubmed publisher
    ..In the present study, we show for the first time that the chaperone protein cyclophilin A (CyPA) acts as a Ca(2+) modulator in platelets...
  68. Balsley M, Malesevic M, Stemmy E, Gigley J, Jurjus R, Herzog D, et al. A cell-impermeable cyclosporine A derivative reduces pathology in a mouse model of allergic lung inflammation. J Immunol. 2010;185:7663-70 pubmed publisher
  69. Tribouillard Tanvier D, Carroll J, Moore R, Striebel J, Chesebro B. Role of cyclophilin A from brains of prion-infected mice in stimulation of cytokine release by microglia and astroglia in vitro. J Biol Chem. 2012;287:4628-39 pubmed publisher
    ..This stimulation was greatly reduced both by antibody to cyclophilin A (CyPA), a known mediator of inflammation in peripheral tissues, and by cyclosporine A, a CyPA inhibitor...
  70. Gogstad G, Hagen I, Korsmo R, Solum N. Characterization of the proteins of isolated human platelet alpha-granules. Evidence for a separate alpha-granule-pool of the glycoproteins IIb and IIIa. Biochim Biophys Acta. 1981;670:150-62 pubmed
    ..The dominant three represented the main granule glycoprotein, glycoprotein IIb and glycoprotein IIIa, respectively. More glycoproteins seem to be present in the alpha-granules than was previously recognized. ..
  71. Ren Y, Wang S, Fan J, Sun S, Li X, Padhiar A, et al. CD147 stimulates hepatoma cells escaping from immune surveillance of T cells by interaction with Cyclophilin A. Biomed Pharmacother. 2016;80:289-297 pubmed publisher
    ..b>Cyclophilin A (CypA) is an intracellular protein promoting inflammation when released from cells...
  72. Ramakrishna S, Kim I, Petrovic V, Malin D, Wang I, Kalin T, et al. Myocardium defects and ventricular hypoplasia in mice homozygous null for the Forkhead Box M1 transcription factor. Dev Dyn. 2007;236:1000-13 pubmed
    ..Foxm1 regulates expression of genes essential for the proliferation of cardiomyocytes during heart development. ..
  73. Sherry B, Zybarth G, Alfano M, Dubrovsky L, Mitchell R, Rich D, et al. Role of cyclophilin A in the uptake of HIV-1 by macrophages and T lymphocytes. Proc Natl Acad Sci U S A. 1998;95:1758-63 pubmed
    ..More recently, host-derived cyclophilin A (CyPA) has been shown to be incorporated into HIV-1 virions and its incorporation essential for viral ..