Ppara

Summary

Gene Symbol: Ppara
Description: peroxisome proliferator activated receptor alpha
Alias: 4933429D07Rik, AW742785, Nr1c1, PPAR-alpha, PPARalpha, Ppar, peroxisome proliferator-activated receptor alpha, nuclear receptor subfamily 1 group C member 1
Species: mouse
Products:     Ppara

Top Publications

  1. Inagaki T, Dutchak P, Zhao G, Ding X, Gautron L, Parameswara V, et al. Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21. Cell Metab. 2007;5:415-25 pubmed
    Peroxisome proliferator-activated receptor alpha (PPARalpha) regulates the utilization of fat as an energy source during starvation and is the molecular target for the fibrate dyslipidemia drugs...
  2. Smeets P, Teunissen B, Willemsen P, van Nieuwenhoven F, Brouns A, Janssen B, et al. Cardiac hypertrophy is enhanced in PPAR alpha-/- mice in response to chronic pressure overload. Cardiovasc Res. 2008;78:79-89 pubmed publisher
    Peroxisome proliferator-activated receptor-alpha (PPARalpha) is a nuclear receptor regulating cardiac metabolism that also has anti-inflammatory properties...
  3. Lundåsen T, Hunt M, Nilsson L, Sanyal S, Angelin B, Alexson S, et al. PPARalpha is a key regulator of hepatic FGF21. Biochem Biophys Res Commun. 2007;360:437-40 pubmed
    ..that the hepatic gene expression of FGF21 is regulated by the peroxisome proliferator-activated receptor alpha (PPARalpha)...
  4. Abdelmegeed M, Moon K, Hardwick J, Gonzalez F, Song B. Role of peroxisome proliferator-activated receptor-alpha in fasting-mediated oxidative stress. Free Radic Biol Med. 2009;47:767-78 pubmed publisher
    ..oxidative stress observed in the fasted Ppara-null mice compared with other groups demonstrate a role for PPAR alpha in fasting-mediated oxidative stress and that inhibition of PPAR alpha functions may increase the susceptibility ..
  5. Barak Y, Kim S. Genetic manipulations of PPARs: effects on obesity and metabolic disease. PPAR Res. 2007;2007:12781 pubmed
    ..Considering the effects of PPAR ligands on critical aspects of systemic physiology, including obesity, lipid metabolism, insulin resistance, and ..
  6. Duncan J, Bharadwaj K, Fong J, Mitra R, Sambandam N, Courtois M, et al. Rescue of cardiomyopathy in peroxisome proliferator-activated receptor-alpha transgenic mice by deletion of lipoprotein lipase identifies sources of cardiac lipids and peroxisome proliferator-activated receptor-alpha activators. Circulation. 2010;121:426-35 pubmed publisher
    ..fatty acid-activated nuclear receptor peroxisome proliferator-activated receptor-alpha (myosin heavy chain [MHC]-PPARalpha mice) exhibit phenotypic features of the diabetic heart, which are rescued by deletion of CD36, a fatty acid ..
  7. Stienstra R, Mandard S, Patsouris D, Maass C, Kersten S, Muller M. Peroxisome proliferator-activated receptor alpha protects against obesity-induced hepatic inflammation. Endocrinology. 2007;148:2753-63 pubmed
    ..The transcription factor peroxisome proliferator-activated receptor alpha (PPARalpha) has been shown to have a strong antiinflammatory action in liver...
  8. Dongol B, Shah Y, Kim I, Gonzalez F, Hunt M. The acyl-CoA thioesterase I is regulated by PPARalpha and HNF4alpha via a distal response element in the promoter. J Lipid Res. 2007;48:1781-91 pubmed
    ..located in the Acot1 gene promoter in mouse, which binds the peroxisome proliferator-activated receptor alpha (PPARalpha) and HNF4alpha...
  9. Chen W, Zhou X, Liu H, Xu C, Wang L, Li S. P633H, a novel dual agonist at peroxisome proliferator-activated receptors alpha and gamma, with different anti-diabetic effects in db/db and KK-Ay mice. Br J Pharmacol. 2009;157:724-35 pubmed publisher
    ..acid), a novel PPARalpha/gamma dual agonist, was investigated for its very different effects on insulin resistance and dyslipidemia in db/..
  10. Gélinas R, Labarthe F, Bouchard B, Mc Duff J, Charron G, Young M, et al. Alterations in carbohydrate metabolism and its regulation in PPARalpha null mouse hearts. Am J Physiol Heart Circ Physiol. 2008;294:H1571-80 pubmed publisher
    ..of CHOs for energy production and anaplerosis in 12-wk-old peroxisome proliferator-activating receptor-alpha (PPARalpha) null mice (a model of FA beta-oxidation defects)...

Detail Information

Publications62

  1. Inagaki T, Dutchak P, Zhao G, Ding X, Gautron L, Parameswara V, et al. Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21. Cell Metab. 2007;5:415-25 pubmed
    Peroxisome proliferator-activated receptor alpha (PPARalpha) regulates the utilization of fat as an energy source during starvation and is the molecular target for the fibrate dyslipidemia drugs...
  2. Smeets P, Teunissen B, Willemsen P, van Nieuwenhoven F, Brouns A, Janssen B, et al. Cardiac hypertrophy is enhanced in PPAR alpha-/- mice in response to chronic pressure overload. Cardiovasc Res. 2008;78:79-89 pubmed publisher
    Peroxisome proliferator-activated receptor-alpha (PPARalpha) is a nuclear receptor regulating cardiac metabolism that also has anti-inflammatory properties...
  3. Lundåsen T, Hunt M, Nilsson L, Sanyal S, Angelin B, Alexson S, et al. PPARalpha is a key regulator of hepatic FGF21. Biochem Biophys Res Commun. 2007;360:437-40 pubmed
    ..that the hepatic gene expression of FGF21 is regulated by the peroxisome proliferator-activated receptor alpha (PPARalpha)...
  4. Abdelmegeed M, Moon K, Hardwick J, Gonzalez F, Song B. Role of peroxisome proliferator-activated receptor-alpha in fasting-mediated oxidative stress. Free Radic Biol Med. 2009;47:767-78 pubmed publisher
    ..oxidative stress observed in the fasted Ppara-null mice compared with other groups demonstrate a role for PPAR alpha in fasting-mediated oxidative stress and that inhibition of PPAR alpha functions may increase the susceptibility ..
  5. Barak Y, Kim S. Genetic manipulations of PPARs: effects on obesity and metabolic disease. PPAR Res. 2007;2007:12781 pubmed
    ..Considering the effects of PPAR ligands on critical aspects of systemic physiology, including obesity, lipid metabolism, insulin resistance, and ..
  6. Duncan J, Bharadwaj K, Fong J, Mitra R, Sambandam N, Courtois M, et al. Rescue of cardiomyopathy in peroxisome proliferator-activated receptor-alpha transgenic mice by deletion of lipoprotein lipase identifies sources of cardiac lipids and peroxisome proliferator-activated receptor-alpha activators. Circulation. 2010;121:426-35 pubmed publisher
    ..fatty acid-activated nuclear receptor peroxisome proliferator-activated receptor-alpha (myosin heavy chain [MHC]-PPARalpha mice) exhibit phenotypic features of the diabetic heart, which are rescued by deletion of CD36, a fatty acid ..
  7. Stienstra R, Mandard S, Patsouris D, Maass C, Kersten S, Muller M. Peroxisome proliferator-activated receptor alpha protects against obesity-induced hepatic inflammation. Endocrinology. 2007;148:2753-63 pubmed
    ..The transcription factor peroxisome proliferator-activated receptor alpha (PPARalpha) has been shown to have a strong antiinflammatory action in liver...
  8. Dongol B, Shah Y, Kim I, Gonzalez F, Hunt M. The acyl-CoA thioesterase I is regulated by PPARalpha and HNF4alpha via a distal response element in the promoter. J Lipid Res. 2007;48:1781-91 pubmed
    ..located in the Acot1 gene promoter in mouse, which binds the peroxisome proliferator-activated receptor alpha (PPARalpha) and HNF4alpha...
  9. Chen W, Zhou X, Liu H, Xu C, Wang L, Li S. P633H, a novel dual agonist at peroxisome proliferator-activated receptors alpha and gamma, with different anti-diabetic effects in db/db and KK-Ay mice. Br J Pharmacol. 2009;157:724-35 pubmed publisher
    ..acid), a novel PPARalpha/gamma dual agonist, was investigated for its very different effects on insulin resistance and dyslipidemia in db/..
  10. Gélinas R, Labarthe F, Bouchard B, Mc Duff J, Charron G, Young M, et al. Alterations in carbohydrate metabolism and its regulation in PPARalpha null mouse hearts. Am J Physiol Heart Circ Physiol. 2008;294:H1571-80 pubmed publisher
    ..of CHOs for energy production and anaplerosis in 12-wk-old peroxisome proliferator-activating receptor-alpha (PPARalpha) null mice (a model of FA beta-oxidation defects)...
  11. Garrido Urbani S, Jemelin S, Deffert C, Carnesecchi S, Basset O, Szyndralewiez C, et al. Targeting vascular NADPH oxidase 1 blocks tumor angiogenesis through a PPAR? mediated mechanism. PLoS ONE. 2011;6:e14665 pubmed publisher
    ..NOX1 silencing decreases endothelial cell migration and tube-like structure formation, through the inhibition of PPAR?, a regulator of NF-?B...
  12. Biscetti F, Gaetani E, Flex A, Aprahamian T, Hopkins T, Straface G, et al. Selective activation of peroxisome proliferator-activated receptor (PPAR)alpha and PPAR gamma induces neoangiogenesis through a vascular endothelial growth factor-dependent mechanism. Diabetes. 2008;57:1394-404 pubmed publisher
    ..In this study, we evaluated whether activation of PPAR alpha and PPAR gamma stimulates neoangiogenesis...
  13. Oishi K, Uchida D, Ishida N. Circadian expression of FGF21 is induced by PPARalpha activation in the mouse liver. FEBS Lett. 2008;582:3639-42 pubmed publisher
    Peroxisome proliferator-activated receptor alpha (PPARalpha) is a nuclear receptor that regulates the expression of genes associated with lipid metabolism...
  14. Leuenberger N, Pradervand S, Wahli W. Sumoylated PPARalpha mediates sex-specific gene repression and protects the liver from estrogen-induced toxicity in mice. J Clin Invest. 2009;119:3138-48 pubmed publisher
    ..Here we show that in mice, PPARalpha has broad female-dependent repressive actions on hepatic genes involved in steroid metabolism and immunity...
  15. Colin S, Bourguignon E, Boullay A, Tousaint J, Huet S, Caira F, et al. Intestine-specific regulation of PPARalpha gene transcription by liver X receptors. Endocrinology. 2008;149:5128-35 pubmed publisher
    ..Here, using gene expression assays, we identified PPARalpha as an intestine-specific LXR target gene...
  16. Iglesias J, Barg S, Vallois D, Lahiri S, Roger C, Yessoufou A, et al. PPAR?/? affects pancreatic ? cell mass and insulin secretion in mice. J Clin Invest. 2012;122:4105-17 pubmed publisher
    b>PPAR?/? protects against obesity by reducing dyslipidemia and insulin resistance via effects in muscle, adipose tissue, and liver. However, its function in pancreas remains ill defined...
  17. Rakhshandehroo M, Hooiveld G, Muller M, Kersten S. Comparative analysis of gene regulation by the transcription factor PPARalpha between mouse and human. PLoS ONE. 2009;4:e6796 pubmed publisher
    Studies in mice have shown that PPARalpha is an important regulator of hepatic lipid metabolism and the acute phase response. However, little information is available on the role of PPARalpha in human liver...
  18. Panigrahy D, Kaipainen A, Huang S, Butterfield C, Barnes C, Fannon M, et al. PPARalpha agonist fenofibrate suppresses tumor growth through direct and indirect angiogenesis inhibition. Proc Natl Acad Sci U S A. 2008;105:985-90 pubmed publisher
    ..Hence, we speculated that pharmacologic activation of PPARalpha would promote tumor growth...
  19. Smeets P, de Vogel van den Bosch H, Willemsen P, Stassen A, Ayoubi T, Van der Vusse G, et al. Transcriptomic analysis of PPARalpha-dependent alterations during cardiac hypertrophy. Physiol Genomics. 2008;36:15-23 pubmed publisher
    ..Although PPARalpha has been shown to mitigate cardiac hypertrophy, knowledge about underlying mechanisms and the nature of ..
  20. Seale P, Bjork B, Yang W, Kajimura S, Chin S, Kuang S, et al. PRDM16 controls a brown fat/skeletal muscle switch. Nature. 2008;454:961-7 pubmed publisher
    ..PRDM16 stimulates brown adipogenesis by binding to PPAR-gamma (peroxisome-proliferator-activated receptor-gamma) and activating its transcriptional function...
  21. Bünger M, van den Bosch H, van der Meijde J, Kersten S, Hooiveld G, Muller M. Genome-wide analysis of PPARalpha activation in murine small intestine. Physiol Genomics. 2007;30:192-204 pubmed
    The peroxisome proliferator-activated receptor alpha (PPARalpha) is a fatty acid-activated transcription factor that governs a variety of biological processes. Little is known about the role of PPARalpha in the small intestine...
  22. Chen H, Chen T, Lin H. Prostacyclin-induced peroxisome proliferator-activated receptor-alpha translocation attenuates NF-kappaB and TNF-alpha activation after renal ischemia-reperfusion injury. Am J Physiol Renal Physiol. 2009;297:F1109-18 pubmed publisher
    ..In this study, we examined the prostacyclin-enhanced protective effect of PPARalpha in I/R-induced kidney injury...
  23. Mysiorek C, Culot M, Dehouck L, Derudas B, Staels B, Bordet R, et al. Peroxisome-proliferator-activated receptor-alpha activation protects brain capillary endothelial cells from oxygen-glucose deprivation-induced hyperpermeability in the blood-brain barrier. Curr Neurovasc Res. 2009;6:181-93 pubmed
    ..Previous studies reported neuroprotection in animal models upon activation of the nuclear receptor PPARalpha(peroxisome proliferator-activated receptor)alpha, but the cellular targets at the BBB level remain largely ..
  24. Guellich A, Damy T, Lecarpentier Y, Conti M, Claes V, Samuel J, et al. Role of oxidative stress in cardiac dysfunction of PPARalpha-/- mice. Am J Physiol Heart Circ Physiol. 2007;293:H93-H102 pubmed
    This study was designed to determine the effects of PPARalpha lack on cardiac mechanical performance and to identify potential intracellular mechanisms linking PPARalpha pathway deficiency to cardiac contractile dysfunction...
  25. Lin H, Yu C, Jen C, Cheng C, Chou Y, Chang C, et al. Adiponectin-mediated heme oxygenase-1 induction protects against iron-induced liver injury via a PPAR? dependent mechanism. Am J Pathol. 2010;177:1697-709 pubmed publisher
    ..Furthermore, AMPK-mediated peroxisome proliferator-activated receptor-? (PPAR?) activation by APN was ascribable to HO-1 induction...
  26. Atherton H, Bailey N, Zhang W, Taylor J, Major H, Shockcor J, et al. A combined 1H-NMR spectroscopy- and mass spectrometry-based metabolomic study of the PPAR-alpha null mutant mouse defines profound systemic changes in metabolism linked to the metabolic syndrome. Physiol Genomics. 2006;27:178-86 pubmed
    ..beta-oxidation in the liver, in part under the regulation of peroxisome proliferator-activated receptor-alpha (PPAR-alpha)...
  27. Tseng Y, Kokkotou E, Schulz T, Huang T, Winnay J, Taniguchi C, et al. New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure. Nature. 2008;454:1000-4 pubmed publisher
    ..These data reveal an important role of BMP7 in promoting brown adipocyte differentiation and thermogenesis in vivo and in vitro, and provide a potential new therapeutic approach for the treatment of obesity. ..
  28. Martinez Jimenez C, Kyrmizi I, Cardot P, Gonzalez F, Talianidis I. Hepatocyte nuclear factor 4alpha coordinates a transcription factor network regulating hepatic fatty acid metabolism. Mol Cell Biol. 2010;30:565-77 pubmed publisher
    ..fed animals, together with HNF4alpha, maintains PPARgamma expression at low levels and represses several PPARalpha-regulated genes...
  29. Bernal Mizrachi C, Xiaozhong L, Yin L, Knutsen R, Howard M, Arends J, et al. An afferent vagal nerve pathway links hepatic PPARalpha activation to glucocorticoid-induced insulin resistance and hypertension. Cell Metab. 2007;5:91-102 pubmed
    Glucocorticoid excess causes insulin resistance and hypertension. Hepatic expression of PPARalpha (Ppara) is required for glucocorticoid-induced insulin resistance...
  30. Son N, Yu S, Tuinei J, Arai K, Hamai H, Homma S, et al. PPAR?-induced cardiolipotoxicity in mice is ameliorated by PPAR? deficiency despite increases in fatty acid oxidation. J Clin Invest. 2010;120:3443-54 pubmed publisher
    ..b>PPAR? expression is increased in the hearts of humans with metabolic syndrome, and use of PPAR? agonists is associated ..
  31. Gao M, Bu L, Ma Y, Liu D. Concurrent activation of liver X receptor and peroxisome proliferator-activated receptor alpha exacerbates hepatic steatosis in high fat diet-induced obese mice. PLoS ONE. 2013;8:e65641 pubmed publisher
    ..Activation of peroxisome proliferator-activated receptor alpha (PPAR?), on the other hand, increases fatty acid oxidation, leading to a reduction of hyperlipidemia...
  32. Standage S, Caldwell C, Zingarelli B, Wong H. Reduced peroxisome proliferator-activated receptor ? expression is associated with decreased survival and increased tissue bacterial load in sepsis. Shock. 2012;37:164-9 pubmed publisher
    The peroxisome proliferator-activated receptor ? (PPAR-?) is a member of the nuclear receptor family with many important physiologic roles related to metabolism and inflammation...
  33. Li F, Patterson A, Krausz K, Tanaka N, Gonzalez F. Metabolomics reveals an essential role for peroxisome proliferator-activated receptor ? in bile acid homeostasis. J Lipid Res. 2012;53:1625-35 pubmed publisher
    ..metabolomics approach was used to profile metabolites in urine, serum, and bile of wild-type and Ppara-null mice following cholic acid (CA) dietary challenge...
  34. Yang Q, Nagano T, Shah Y, Cheung C, Ito S, Gonzalez F. The PPAR alpha-humanized mouse: a model to investigate species differences in liver toxicity mediated by PPAR alpha. Toxicol Sci. 2008;101:132-9 pubmed
    ..response to peroxisome proliferators (PPs) mediated by peroxisome proliferator-activated receptor (PPAR)alpha, PPAR alpha-humanized transgenic mice were generated using a P1 phage artificial chromosome (PAC) genomic clone bred onto a ..
  35. Shah Y, Morimura K, Yang Q, Tanabe T, Takagi M, Gonzalez F. Peroxisome proliferator-activated receptor alpha regulates a microRNA-mediated signaling cascade responsible for hepatocellular proliferation. Mol Cell Biol. 2007;27:4238-47 pubmed
    Activation of peroxisome proliferator-activated receptor alpha (PPARalpha) leads to hepatocellular proliferation and liver carcinomas. The early events mediating these effects are unknown...
  36. Huang J, Viswakarma N, Yu S, Jia Y, Bai L, Vluggens A, et al. Progressive endoplasmic reticulum stress contributes to hepatocarcinogenesis in fatty acyl-CoA oxidase 1-deficient mice. Am J Pathol. 2011;179:703-13 pubmed publisher
    ..substrates of this enzyme that function as biological ligands for peroxisome proliferator-activated receptor-? (PPAR?) in liver...
  37. Lalloyer F, Wouters K, Baron M, Caron S, Vallez E, Vanhoutte J, et al. Peroxisome proliferator-activated receptor-alpha gene level differently affects lipid metabolism and inflammation in apolipoprotein E2 knock-in mice. Arterioscler Thromb Vasc Biol. 2011;31:1573-9 pubmed publisher
    Peroxisome proliferator-activated receptor-? (PPAR?) is a ligand-activated transcription factor that controls lipid metabolism and inflammation. PPAR? is activated by fibrates, hypolipidemic drugs used in the treatment of dyslipidemia...
  38. Uchida A, Slipchenko M, Cheng J, Buhman K. Fenofibrate, a peroxisome proliferator-activated receptor ? agonist, alters triglyceride metabolism in enterocytes of mice. Biochim Biophys Acta. 2011;1811:170-6 pubmed publisher
    ..These results suggest that the effects of fenofibrate on the small intestine play a critical role in the hypotriglyceridemic effects of fenofibrate...
  39. Han K, Choi J, Lee J, Song J, Joe M, Jung M, et al. Therapeutic potential of peroxisome proliferators--activated receptor-alpha/gamma dual agonist with alleviation of endoplasmic reticulum stress for the treatment of diabetes. Diabetes. 2008;57:737-45 pubmed
    ..This study evaluated the function of macelignan, a natural compound isolated from Myristica fragrans, as a dual agonist for PPARalpha/gamma and investigated its antidiabetes effects in animal models.
  40. Schmutz I, Ripperger J, Baeriswyl Aebischer S, Albrecht U. The mammalian clock component PERIOD2 coordinates circadian output by interaction with nuclear receptors. Genes Dev. 2010;24:345-57 pubmed publisher
    ..PER2 interacts with nuclear receptors including PPARalpha and REV-ERBalpha and serves as a coregulator of nuclear receptor-mediated transcription...
  41. Pozzi A, Ibanez M, Gatica A, Yang S, Wei S, Mei S, et al. Peroxisomal proliferator-activated receptor-alpha-dependent inhibition of endothelial cell proliferation and tumorigenesis. J Biol Chem. 2007;282:17685-95 pubmed
    The peroxisomal proliferator-activated nuclear receptor-alpha (PPARalpha), the target for most hypolipidemic drugs in current clinical use, regulates the transcription of genes involved in lipid metabolism and transport, and energy ..
  42. Ding L, Liang X, Zhu D, Lou Y. Peroxisome proliferator-activated receptor alpha is involved in cardiomyocyte differentiation of murine embryonic stem cells in vitro. Cell Biol Int. 2007;31:1002-9 pubmed
    Peroxisome proliferator-activated receptor alpha (PPARalpha) plays a key role in the transcriptional regulation of genes involved in cellular lipid and energy metabolism, which is abundantly expressed in tissues with high energy demand, ..
  43. Mansouri R, Bauge E, Staels B, Gervois P. Systemic and distal repercussions of liver-specific peroxisome proliferator-activated receptor-alpha control of the acute-phase response. Endocrinology. 2008;149:3215-23 pubmed publisher
    ..We previously found that peroxisome proliferator-activated receptor-alpha (PPARalpha) agonists attenuate the IL-6 induction of acute-phase response gene expression in vitro and in vivo...
  44. Burkart E, Sambandam N, Han X, Gross R, Courtois M, Gierasch C, et al. Nuclear receptors PPARbeta/delta and PPARalpha direct distinct metabolic regulatory programs in the mouse heart. J Clin Invest. 2007;117:3930-9 pubmed
    In the diabetic heart, chronic activation of the PPARalpha pathway drives excessive fatty acid (FA) oxidation, lipid accumulation, reduced glucose utilization, and cardiomyopathy...
  45. Fujita K, Maeda N, Sonoda M, Ohashi K, Hibuse T, Nishizawa H, et al. Adiponectin protects against angiotensin II-induced cardiac fibrosis through activation of PPAR-alpha. Arterioscler Thromb Vasc Biol. 2008;28:863-70 pubmed publisher
    ..Wild-type (WT), adiponectin knockout (Adipo-KO), and PPAR-alpha knockout (PPAR-alpha-KO) mice were infused with Ang II at 1.2 mg/kg/d...
  46. Biscetti F, Gaetani E, Flex A, Straface G, Pecorini G, Angelini F, et al. Peroxisome proliferator-activated receptor alpha is crucial for iloprost-induced in vivo angiogenesis and vascular endothelial growth factor upregulation. J Vasc Res. 2009;46:103-8 pubmed publisher
    ..angiogenesis and VEGF upregulation are modulated by peroxisome proliferator-activated receptor-alpha (PPARalpha), a ligand-inducible transcription factor that belongs to the nuclear hormone receptor superfamily and plays ..
  47. Dalen K, Dahl T, Holter E, Arntsen B, Londos C, Sztalryd C, et al. LSDP5 is a PAT protein specifically expressed in fatty acid oxidizing tissues. Biochim Biophys Acta. 2007;1771:210-27 pubmed
    ..Expression of LSDP5 is stimulated by ligand activation of peroxisomal proliferator-activated receptor alpha (PPARalpha), and significantly reduced in liver and heart in the absence of this transcription factor...
  48. Longuet C, Sinclair E, Maida A, Baggio L, Maziarz M, Charron M, et al. The glucagon receptor is required for the adaptive metabolic response to fasting. Cell Metab. 2008;8:359-71 pubmed publisher
    ..The actions of glucagon on TG synthesis and FAO were abolished in PPARalpha-/- hepatocytes...
  49. Knauf C, Rieusset J, Foretz M, Cani P, Uldry M, Hosokawa M, et al. Peroxisome proliferator-activated receptor-alpha-null mice have increased white adipose tissue glucose utilization, GLUT4, and fat mass: Role in liver and brain. Endocrinology. 2006;147:4067-78 pubmed
    ..Here we compared PPARalpha knockout mice with wild type and confirmed that the former developed hypoglycemia during fasting...
  50. Fernández Alvarez A, Alvarez M, Gonzalez R, Cucarella C, Muntane J, Casado M. Human SREBP1c expression in liver is directly regulated by peroxisome proliferator-activated receptor alpha (PPARalpha). J Biol Chem. 2011;286:21466-77 pubmed publisher
    ..We discovered that peroxisome proliferation-activated receptor alpha (PPAR?) agonists enhance the activity of the SREBP1c promoter; a DR1 element, at -453 in the human promoter was involved ..
  51. Ahmadian M, Abbott M, Tang T, Hudak C, Kim Y, Bruss M, et al. Desnutrin/ATGL is regulated by AMPK and is required for a brown adipose phenotype. Cell Metab. 2011;13:739-48 pubmed publisher
    ..thermogenesis with increased expression of WAT-enriched genes but decreased BAT genes, including UCP-1 with lower PPAR? binding to its promoter, revealing the requirement of desnutrin-catalyzed lipolysis for maintaining a BAT ..
  52. Valasek M, Clarke S, Repa J. Fenofibrate reduces intestinal cholesterol absorption via PPARalpha-dependent modulation of NPC1L1 expression in mouse. J Lipid Res. 2007;48:2725-35 pubmed
    ..These effects of fenofibrate are dependent on PPARalpha, as Ppar alpha-knockout mice fail to respond like wild-type littermates...
  53. Neschen S, Morino K, Dong J, Wang Fischer Y, Cline G, Romanelli A, et al. n-3 Fatty acids preserve insulin sensitivity in vivo in a peroxisome proliferator-activated receptor-alpha-dependent manner. Diabetes. 2007;56:1034-41 pubmed
    ..oil, protect against high-fat diet-induced insulin resistance through peroxisome proliferator-activated receptor (PPAR)-alpha activation and a subsequent decrease in intracellular lipid abundance...
  54. Wolins N, Quaynor B, Skinner J, Tzekov A, Croce M, Gropler M, et al. OXPAT/PAT-1 is a PPAR-induced lipid droplet protein that promotes fatty acid utilization. Diabetes. 2006;55:3418-28 pubmed
    ..pharmacological (peroxisome proliferator-activated receptor [PPAR] agonists), and genetic (muscle-specific PPARalpha overexpression) perturbations that increase fatty acid utilization...
  55. Ducheix S, Podechard N, Lasserre F, Polizzi A, Pommier A, Murzilli S, et al. A systems biology approach to the hepatic role of the oxysterol receptor LXR in the regulation of lipogenesis highlights a cross-talk with PPAR?. Biochimie. 2013;95:556-67 pubmed publisher
    The Liver X Receptors (LXRs) ? and ? and the Peroxisome Proliferator-Activated Receptor ? (PPAR?) are transcription factors that belong to class II nuclear receptors...
  56. Boergesen M, Pedersen T, Gross B, van Heeringen S, Hagenbeek D, Bindesbøll C, et al. Genome-wide profiling of liver X receptor, retinoid X receptor, and peroxisome proliferator-activated receptor ? in mouse liver reveals extensive sharing of binding sites. Mol Cell Biol. 2012;32:852-67 pubmed publisher
    ..association with classical LXR-regulated pathways as well as peroxisome proliferator-activated receptor (PPAR) signaling pathways, and subsequent chromatin immunoprecipitation-sequencing (ChIP-seq) mapping of PPAR? binding ..
  57. Damiano F, Gnoni G, Siculella L. Citrate carrier promoter is target of peroxisome proliferator-activated receptor alpha and gamma in hepatocytes and adipocytes. Int J Biochem Cell Biol. 2012;44:659-68 pubmed publisher
    ..we provide evidences demonstrating that CiC expression is regulated by peroxisome proliferator-activated receptor (PPAR) alpha and gamma in hepatocytes and adipocytes, respectively...
  58. Hu Y, Chen Y, Ding L, He X, Takahashi Y, Gao Y, et al. Pathogenic role of diabetes-induced PPAR-? down-regulation in microvascular dysfunction. Proc Natl Acad Sci U S A. 2013;110:15401-6 pubmed publisher
    Two independent clinical studies have reported that fenofibrate, a peroxisome proliferator-activated receptor ? (PPAR?) agonist, has robust therapeutic effects on microvascular complications of diabetes, including diabetic retinopathy (DR)..
  59. Bernal Mizrachi C, Weng S, Feng C, Finck B, Knutsen R, Leone T, et al. Dexamethasone induction of hypertension and diabetes is PPAR-alpha dependent in LDL receptor-null mice. Nat Med. 2003;9:1069-75 pubmed
    ..PPAR-alpha) mediates these sequelae, mice deficient in low-density lipoprotein receptor (Ldlr-/-), with (Ppara+/+) or without (Ppara-/-) PPAR-alpha, were treated chronically with dexamethasone...
  60. Anderson S, Yoon L, Richard E, Dunn C, Cattley R, Corton J. Delayed liver regeneration in peroxisome proliferator-activated receptor-alpha-null mice. Hepatology. 2002;36:544-54 pubmed
    Peroxisome proliferator chemicals, acting via the peroxisome proliferator-activated receptor-alpha (Pparalpha), are potent hepatic mitogens and carcinogens in mice and rats...
  61. Watanabe K, Fujii H, Takahashi T, Kodama M, Aizawa Y, Ohta Y, et al. Constitutive regulation of cardiac fatty acid metabolism through peroxisome proliferator-activated receptor alpha associated with age-dependent cardiac toxicity. J Biol Chem. 2000;275:22293-9 pubmed
    The peroxisome proliferator-activated receptor alpha (PPARalpha) is a member of the nuclear receptor superfamily and mediates the biological effects of peroxisome proliferators...
  62. Poynter M, Daynes R. Peroxisome proliferator-activated receptor alpha activation modulates cellular redox status, represses nuclear factor-kappaB signaling, and reduces inflammatory cytokine production in aging. J Biol Chem. 1998;273:32833-41 pubmed
    ..aged mice of agents capable of activating the alpha isoform of the peroxisome proliferator-activated receptor (PPARalpha) was found to restore the cellular redox balance, evidenced by a lowering of tissue lipid peroxidation, an ..