Gene Symbol: Ppa1
Description: pyrophosphatase (inorganic) 1
Alias: 2010317E03Rik, Pyp, inorganic pyrophosphatase, PPase, pyrophosphate phospho-hydrolase
Lalley P, Francke U, Minna J. Assignment of the genes coding for pyrophosphatase and hexokinase-1 to mouse chromosome 10: implications for comparative gene mapping in man and mouse. Cytogenet Cell Genet. 1978;22:570-2 pubmed
O Brien S, Nash W. Genetic mapping in mammals: chromosome map of domestic cat. Science. 1982;216:257-65 pubmed
..Many of these same linkage groups have not been conserved in the murine genome. The genetic and evolutionary implications of comparative mapping analysis among mammalian species are discussed. ..
Tezuka Y, Okada M, Tada Y, Yamauchi J, Nishigori H, Sanbe A. Regulation of neurite growth by inorganic pyrophosphatase 1 via JNK dephosphorylation. PLoS ONE. 2013;8:e61649 pubmed publisher
..In this study, we examined the role of pyrophosphatase1 (PPA1) in neuronal differentiation using the loss and gain of function analysis...
Lalley P, Minna J, Francke U. Conservation of autosomal gene synteny groups in mouse and man. Nature. 1978;274:160-3 pubmed
Naylor S, Gray P, Lalley P. Mouse immune interferon (IFN-gamma) gene is on chromosome 10. Somat Cell Mol Genet. 1984;10:531-4 pubmed
..This region of chromosome 12 also contains the genes for peptidase B and citrate synthase. The homologous genes in mouse are also located on chromosome 10, suggesting that these genes comprise a conserved linkage group. ..
Zobeley E, Sufalko D, Adkins S, Burmeister M. Fine genetic and comparative mapping of the deafness mutation Ames waltzer on mouse chromosome 10. Genomics. 1998;50:260-6 pubmed
..In addition, nine different genes (Ank3, Bcr, Gnaz, Tfam, Mif, Mmp11, Dcoh, Pyp, and Gstt2) were mapped and eliminated genetically as candidate genes for av...
Yang D, Li Q, So I, Huang C, Ando H, Mizutani A, et al
. IRBIT governs epithelial secretion in mice by antagonizing the WNK/SPAK kinase pathway. J Clin Invest. 2011;121:956-65 pubmed publisher
..They also have implications for WNK/SPAK kinase-regulated processes involved in systemic fluid homeostasis, hypertension, and cystic fibrosis. ..