pp GalNAc T13

Summary

Gene Symbol: pp GalNAc T13
Description: polypeptide N-acetylgalactosaminyltransferase 13
Alias: A230002A12, A230020F20, BB182356, polypeptide N-acetylgalactosaminyltransferase 13, UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 13, UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13, galNAc-T13, polypeptide GalNAc transferase 13, pp-GaNTase 13, pp-GalNAc-T13, protein-UDP acetylgalactosaminyltransferase 13
Species: mouse
Products:     pp GalNAc T13

Top Publications

  1. Young W, Holcomb D, Ten Hagen K, Tabak L. Expression of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase isoforms in murine tissues determined by real-time PCR: a new view of a large family. Glycobiology. 2003;13:549-57 pubmed
  2. Zhang Y, Iwasaki H, Wang H, Kudo T, Kalka T, Hennet T, et al. Cloning and characterization of a new human UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase, designated pp-GalNAc-T13, that is specifically expressed in neurons and synthesizes GalNAc alpha-serine/threonine antigen. J Biol Chem. 2003;278:573-84 pubmed
    ..pp-GalNAc-T13 would be a major enzyme responsible for the synthesis of O-glycan and specifically the Tn antigen epitope in neurons. ..
  3. Matsumoto Y, Zhang Q, Akita K, Nakada H, Hamamura K, Tokuda N, et al. pp-GalNAc-T13 induces high metastatic potential of murine Lewis lung cancer by generating trimeric Tn antigen. Biochem Biophys Res Commun. 2012;419:7-13 pubmed publisher
    ..These data suggested that high expression of pp-GalNAc-T13 gene generated trimeric Tn antigen on Syndecan-1, leading to the enhanced metastasis. ..
  4. Matsumoto Y, Zhang Q, Akita K, Nakada H, Hamamura K, Tsuchida A, et al. Trimeric Tn antigen on syndecan 1 produced by ppGalNAc-T13 enhances cancer metastasis via a complex formation with integrin ?5?1 and matrix metalloproteinase 9. J Biol Chem. 2013;288:24264-76 pubmed publisher
  5. Xu Y, Pang W, Lu J, Shan A, Zhang Y. Polypeptide N-Acetylgalactosaminyltransferase 13 Contributes to Neurogenesis via Stabilizing the Mucin-type O-Glycoprotein Podoplanin. J Biol Chem. 2016;291:23477-23488 pubmed
  6. Hennet T, Hagen F, Tabak L, Marth J. T-cell-specific deletion of a polypeptide N-acetylgalactosaminyl-transferase gene by site-directed recombination. Proc Natl Acad Sci U S A. 1995;92:12070-4 pubmed
    ..These results indicate a complexity in vertebrate O-glycan biosynthesis that involves multiple polypeptide GalNAc-Ts. We infer the potential for protein-specific O-glycan formation governed by distinct polypeptide GalNAc-Ts. ..