Pon1

Summary

Gene Symbol: Pon1
Description: paraoxonase 1
Alias: Pon, serum paraoxonase/arylesterase 1, A-esterase 1, PON 1, aromatic esterase 1, serum aryldialkylphosphatase 1
Species: mouse
Products:     Pon1

Top Publications

  1. Shih D, Lusis A. The roles of PON1 and PON2 in cardiovascular disease and innate immunity. Curr Opin Lipidol. 2009;20:288-92 pubmed publisher
    The paraoxonase (PON) gene family includes three members, PON1, PON2, and PON3. In-vitro and mouse studies have demonstrated that all three PONs are atheroprotective...
  2. Rosenblat M, Vaya J, Shih D, Aviram M. Paraoxonase 1 (PON1) enhances HDL-mediated macrophage cholesterol efflux via the ABCA1 transporter in association with increased HDL binding to the cells: a possible role for lysophosphatidylcholine. Atherosclerosis. 2005;179:69-77 pubmed
    We investigated the role of HDL-associated paraoxonase 1 (PON1) in HDL-mediated macrophage cholesterol efflux by using HDL derived from wild type mice (Control-HDL), from human PON1-transgenic mice (HDL-PON1Tg) or from PON1-knockout mice (..
  3. García Heredia A, Kensicki E, Mohney R, Rull A, Triguero I, Marsillach J, et al. Paraoxonase-1 deficiency is associated with severe liver steatosis in mice fed a high-fat high-cholesterol diet: a metabolomic approach. J Proteome Res. 2013;12:1946-55 pubmed publisher
    ..The present study investigated the effect of paraoxonase-1 (PON1) deficiency on histological alterations and hepatic metabolism in mice fed a high-fat high-cholesterol diet...
  4. Ribas V, Sanchez Quesada J, Anton R, Camacho M, Julve J, Escola Gil J, et al. Human apolipoprotein A-II enrichment displaces paraoxonase from HDL and impairs its antioxidant properties: a new mechanism linking HDL protein composition and antiatherogenic potential. Circ Res. 2004;95:789-97 pubmed
    ..1 transgenic mice failed to protect LDL from oxidative modification. A decreased content of apoA-I, paraoxonase (PON1), and platelet-activated factor acetyl-hydrolase activities was found in HDL of 11.1 transgenic mice...
  5. Shih D, Gu L, Xia Y, Navab M, Li W, Hama S, et al. Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosis. Nature. 1998;394:284-7 pubmed
    Serum paraoxonase (PON1) is an esterase that is associated with high-density lipoproteins (HDLs) in the plasma; it is involved in the detoxification of organophosphate insecticides such as parathion and chlorpyrifos...
  6. Shih D, Xia Y, Wang X, Miller E, Castellani L, Subbanagounder G, et al. Combined serum paraoxonase knockout/apolipoprotein E knockout mice exhibit increased lipoprotein oxidation and atherosclerosis. J Biol Chem. 2000;275:17527-35 pubmed
    Serum paraoxonase (PON1), present on high density lipoprotein, may inhibit low density lipoprotein (LDL) oxidation and protect against atherosclerosis...
  7. Draganov D, Teiber J, Watson C, Bisgaier C, Nemzek J, Remick D, et al. PON1 and oxidative stress in human sepsis and an animal model of sepsis. Adv Exp Med Biol. 2010;660:89-97 pubmed publisher
    ..Oxidative stress is a major promoter and mediator of the systemic inflammatory response. Serum PON1 has been demonstrated in multiple clinical and animal studies to protect against oxidative stress, but also to ..
  8. Ozer E, Pezzulo A, Shih D, Chun C, Furlong C, Lusis A, et al. Human and murine paraoxonase 1 are host modulators of Pseudomonas aeruginosa quorum-sensing. FEMS Microbiol Lett. 2005;253:29-37 pubmed
    ..We found that paraoxonase 1 (PON1), a mammalian lactonase with an unknown natural substrate, hydrolyzed the P. aeruginosa acyl-HSL 3OC12-HSL...
  9. Cole T, Jansen K, Park S, Li W, Furlong C, Costa L. The toxicity of mixtures of specific organophosphate compounds is modulated by paraoxonase 1 status. Adv Exp Med Biol. 2010;660:47-60 pubmed publisher
    Most chemical exposures involve complex mixtures. The role of paraoxonase 1 (PON1) and the Q192R polymorphism in the detoxication of individual organophosphorous (OP) compounds has been well-established...

More Information

Publications62

  1. Tward A, Xia Y, Wang X, Shi Y, Park C, Castellani L, et al. Decreased atherosclerotic lesion formation in human serum paraoxonase transgenic mice. Circulation. 2002;106:484-90 pubmed
    Serum paraoxonase (PON1), an enzyme carried on HDL, inhibits LDL oxidation, and in human population studies, low PON1 activity is associated with atherosclerosis...
  2. Burillo E, Tarin C, Torres Fonseca M, Fernandez García C, Martinez Pinna R, Martinez Lopez D, et al. Paraoxonase-1 overexpression prevents experimental abdominal aortic aneurysm progression. Clin Sci (Lond). 2016;130:1027-38 pubmed publisher
    ..Among identified proteins, paraoxonase-1 (PON1) was decreased in plasma of AAA patients compared with controls, which was further validated in a bigger cohort of ..
  3. Oczos J, Sutter I, Kloeckener Gruissem B, Berger W, Riwanto M, Rentsch K, et al. Lack of paraoxonase 1 alters phospholipid composition, but not morphology and function of the mouse retina. Invest Ophthalmol Vis Sci. 2014;55:4714-27 pubmed publisher
    Biochemical and genetic analyses established a contribution of lipid metabolism to AMD pathology. Paraoxonase 1 (PON1) is an antioxidative protein involved in high density lipoprotein (HDL) function and was found to be associated with AMD...
  4. Kumar D, Rizvi S. Age-dependent paraoxonase 1 (PON1) activity and LDL oxidation in Wistar rats during their entire lifespan. ScientificWorldJournal. 2014;2014:538049 pubmed publisher
    Paraoxonase 1 (PON1) is an HDL bound enzyme which plays a key role in the protection of LDL and HDL from oxidation by hydrolyzing activated phospholipids and lipid peroxide products...
  5. Sayin V, Nilton A, Ibrahim M, Agren P, Larsson E, Petit M, et al. Zfp148 deficiency causes lung maturation defects and lethality in newborn mice that are rescued by deletion of p53 or antioxidant treatment. PLoS ONE. 2013;8:e55720 pubmed publisher
    ..Our results establish Zfp148 as a novel player in mammalian lung maturation and demonstrate that Zfp148 is critical for cell cycle progression in vivo. ..
  6. Bhasin K, Yu J, Tward A, Shih D, Campbell D, Lusis A. Trypanosoma congolense: paraoxonase 1 prolongs survival of infected mice. Exp Parasitol. 2006;114:240-5 pubmed
    ..the involvement of two proteins located in the TLF fraction, apolipoprotein A-II (apoA-II) and paraoxonase 1 (PON1), against trypanosome infection...
  7. Janel N, Robert K, Chabert C, Ledru A, Gouédard C, Barouki R, et al. Mouse liver paraoxonase-1 gene expression is downregulated in hyperhomocysteinemia. Thromb Haemost. 2004;92:221-2 pubmed
  8. Jakubowski H. The role of paraoxonase 1 in the detoxification of homocysteine thiolactone. Adv Exp Med Biol. 2010;660:113-27 pubmed publisher
    ..One such mechanism involves paraoxonase 1 (PON1), which has the ability to hydrolyze Hcy-thiolactone...
  9. Suszynska Zajczyk J, Sikora M, Jakubowski H. Paraoxonase 1 deficiency and hyperhomocysteinemia alter the expression of mouse kidney proteins involved in renal disease. Mol Genet Metab. 2014;113:200-6 pubmed publisher
    ..Paraoxonase 1 (Pon1), a hydrolase that participates in homocysteine (Hcy) metabolism and is carried in the circulation on high-density ..
  10. Furlong C, Li W, Costa L, Richter R, Shih D, Lusis A. Genetically determined susceptibility to organophosphorus insecticides and nerve agents: developing a mouse model for the human PON1 polymorphism. Neurotoxicology. 1998;19:645-50 pubmed
    Several organophosphorus insecticides and nerve agents are detoxified through the cytochrome P450/paraoxonase (PON1) pathway. PON1 is an HDL-associated enzyme encoded as a 355 amino acid protein in humans...
  11. Tolgyesi G, Molnar V, Semsei A, Kiszel P, Ungvári I, Pocza P, et al. Gene expression profiling of experimental asthma reveals a possible role of paraoxonase-1 in the disease. Int Immunol. 2009;21:967-75 pubmed publisher
    ..Among the top down-regulated transcripts, an anti-oxidant enzyme, paraoxonase-1 (PON1), was identified...
  12. Rosenblat M, Volkova N, Aviram M. HDL3 stimulates paraoxonase 1 antiatherogenic catalytic and biological activities in a macrophage model system: in vivo and in vitro studies. Biofactors. 2014;40:536-45 pubmed publisher
    We analyzed in-vivo and in-vitro high density lipoprotein (HDL) effects on paraoxonase 1 (PON1) antiatherogenic properties in serum and in macrophages...
  13. Parker Katiraee L, Bousiaki E, Monk D, Moore G, Nakabayashi K, Scherer S. Dynamic variation in allele-specific gene expression of Paraoxonase-1 in murine and human tissues. Hum Mol Genet. 2008;17:3263-70 pubmed publisher
    ..We measured the expression of the murine Paraoxonase-1 gene (Pon1) in livers at different stages of embryonic development using F1 hybrid crosses and quantified the transcriptional ..
  14. Cheng X, Klaassen C. Hormonal and chemical regulation of paraoxonases in mice. J Pharmacol Exp Ther. 2012;342:688-95 pubmed publisher
    ..However, the underlining mechanisms of gender-divergent expression and chemical regulation of Pon1 remain largely unknown...
  15. Koren Gluzer M, Aviram M, Hayek T. Paraoxonase1 (PON1) reduces insulin resistance in mice fed a high-fat diet, and promotes GLUT4 overexpression in myocytes, via the IRS-1/Akt pathway. Atherosclerosis. 2013;229:71-8 pubmed publisher
    To analyze Paraoxonase1 (PON1) impact on GLUT4 expression, glucose metabolism, and the insulin signaling pathway in skeletal muscle cells...
  16. Primo Parmo S, Sorenson R, Teiber J, La Du B. The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family. Genomics. 1996;33:498-507 pubmed
    A physiological role for paraoxonase (PON1) is still uncertain, but it catalyzes the hydrolysis of toxic organophosphates. Evidence that the human genome contains two PON1-like genes, designated PON2 and PON3, is presented here...
  17. McNally E, Ly C, Kunkel L. Human epsilon-sarcoglycan is highly related to alpha-sarcoglycan (adhalin), the limb girdle muscular dystrophy 2D gene. FEBS Lett. 1998;422:27-32 pubmed
    ..The characterization of epsilon-sarcoglycan should make it possible to determine if it, like the other sarcoglycan genes, is mutated in muscular dystrophy. ..
  18. Forte T, Oda M, Knoff L, Frei B, Suh J, Harmony J, et al. Targeted disruption of the murine lecithin:cholesterol acyltransferase gene is associated with reductions in plasma paraoxonase and platelet-activating factor acetylhydrolase activities but not in apolipoprotein J concentration. J Lipid Res. 1999;40:1276-83 pubmed
    ..LCAT deficiency in mice is associated with a concomitant decrease in two antioxidative enzymes, paraoxonase (PON) and platelet-activating factor acetylhydrolase (PAF-AH)...
  19. Tong L, Perez Polo J. Effect of nerve growth factor on AP-1, NF-kappa B, and Oct DNA binding activity in apoptotic PC12 cells: extrinsic and intrinsic elements. J Neurosci Res. 1996;45:1-12 pubmed
    ..Our results suggest that AP-1 is likely to be a common component of signaling pathways associated with both the induction or suppression of apoptosis induced by intrinsic or extrinsic stimuli. ..
  20. Suszynska Zajczyk J, Luczak M, Marczak L, Jakubowski H. Inactivation of the paraoxonase 1 gene affects the expression of mouse brain proteins involved in neurodegeneration. J Alzheimers Dis. 2014;42:247-60 pubmed publisher
    Homocysteine (Hcy) is a risk factor for Alzheimer's disease (AD). Paraoxonase 1 (Pon1) participates in Hcy metabolism and is also linked to AD...
  21. Rodríguez Sanabria F, Rull A, Beltran Debon R, Aragones G, Camps J, Mackness B, et al. Tissue distribution and expression of paraoxonases and chemokines in mouse: the ubiquitous and joint localisation suggest a systemic and coordinated role. J Mol Histol. 2010;41:379-86 pubmed publisher
    ..Using immunohistochemistry and quantitative real-time PCR we have investigated the distribution of PON1, 2 and 3, CCL2, 7, 8 and 12 and the chemokine receptor CCR2 protein and mRNA in 23 tissues from C57BL/6J mice...
  22. Huang Y, Wu Z, Riwanto M, Gao S, Levison B, Gu X, et al. Myeloperoxidase, paraoxonase-1, and HDL form a functional ternary complex. J Clin Invest. 2013;123:3815-28 pubmed publisher
    Myeloperoxidase (MPO) and paraoxonase 1 (PON1) are high-density lipoprotein-associated (HDL-associated) proteins mechanistically linked to inflammation, oxidant stress, and atherosclerosis...
  23. Van Eck M, Hoekstra M, Hildebrand R, Yaong Y, Stengel D, Kruijt J, et al. Increased oxidative stress in scavenger receptor BI knockout mice with dysfunctional HDL. Arterioscler Thromb Vasc Biol. 2007;27:2413-9 pubmed
    ..of SR-BI, a prominent regulator of HDL metabolism, on the activity of the HDL-associated antioxidant enzymes PON1 and PAF-AH as well as in vivo oxidative stress were investigated. SR-BI deficiency resulted in 1.4-fold (P<0...
  24. Rozenberg O, Shiner M, Aviram M, Hayek T. Paraoxonase 1 (PON1) attenuates diabetes development in mice through its antioxidative properties. Free Radic Biol Med. 2008;44:1951-9 pubmed publisher
    Paraoxonase 1 (PON1) is a lipo-lactonase which is associated with HDL and possesses antioxidative properties. Diabetes is characterized by increased oxidative stress and by decreased PON1 activity...
  25. Borowczyk K, Shih D, Jakubowski H. Metabolism and neurotoxicity of homocysteine thiolactone in mice: evidence for a protective role of paraoxonase 1. J Alzheimers Dis. 2012;30:225-31 pubmed publisher
    ..Paraoxonase 1 (Pon1), a component of high-density lipoprotein, hydrolyzes Hcy-thiolactone in vitro...
  26. Cole T, Li W, Co A, Hay A, MacDonald J, Bammler T, et al. Repeated gestational exposure of mice to chlorpyrifos oxon is associated with paraoxonase 1 (PON1) modulated effects in maternal and fetal tissues. Toxicol Sci. 2014;141:409-22 pubmed publisher
    ..CPO is hydrolyzed by paraoxonase-1 (PON1), with protection determined by PON1 levels and the human Q192R polymorphism...
  27. Gutierrez A, Ratliff E, Andres A, Huang X, McKeehan W, Davis R. Bile acids decrease hepatic paraoxonase 1 expression and plasma high-density lipoprotein levels via FXR-mediated signaling of FGFR4. Arterioscler Thromb Vasc Biol. 2006;26:301-6 pubmed
    The purpose of this research was to determine how dietary bile acids repress hepatic expression of paraoxonase 1 (PON1)...
  28. Gamliel Lazarovich A, Gantman A, Shiner M, Coleman R, Aviram M, Keidar S. Paraoxonase 1 deficiency in mice is associated with reduced steroid biosynthesis: effects on HDL binding, cholesteryl ester accumulation and scavenger receptor type BI expression. Atherosclerosis. 2010;211:130-5 pubmed publisher
    ..As paraoxonase 1 (PON1) is an HDL-associated lipo-lactonase that has been shown to increase binding of HDL to macrophages, we used PON1 ..
  29. Koren Gluzer M, Aviram M, Meilin E, Hayek T. The antioxidant HDL-associated paraoxonase-1 (PON1) attenuates diabetes development and stimulates ?-cell insulin release. Atherosclerosis. 2011;219:510-8 pubmed publisher
    To analyze the direct effects of paraoxonase-1 (PON1) on diabetes development and on ?-cell insulin release...
  30. Aharoni S, Aviram M, Fuhrman B. Paraoxonase 1 (PON1) reduces macrophage inflammatory responses. Atherosclerosis. 2013;228:353-61 pubmed publisher
    Paraoxonase 1 (PON1) was suggested to play an anti-inflammatory role. In the present study we questioned whether PON1 has a direct impact on macrophage inflammatory responses, and the possible functional implications of such effects...
  31. Furlong C, Cole T, Walter B, Shih D, Tward A, Lusis A, et al. Paraoxonase 1 (PON1) status and risk of insecticide exposure. J Biochem Mol Toxicol. 2005;19:182-3 pubmed
  32. Clendenning J, Humbert R, Green E, Wood C, Traver D, Furlong C. Structural organization of the human PON1 gene. Genomics. 1996;35:586-9 pubmed
    Serum paraoxonase/arylesterase (PON) is an "A" esterase found in the HDL2 fraction of mammalian sera closely associated with apolipoproteins A1 and J...
  33. Cole T, Beyer R, Bammler T, Park S, Farin F, Costa L, et al. Repeated developmental exposure of mice to chlorpyrifos oxon is associated with paraoxonase 1 (PON1)-modulated effects on cerebellar gene expression. Toxicol Sci. 2011;123:155-69 pubmed publisher
    ..The high-density lipoprotein-associated enzyme paraoxonase 1 (PON1) plays a significant role in the detoxication of CPO, which is present in exposures and generated from chlorpyrifos ..
  34. Sogorb M, García Argüelles S, Carrera V, Vilanova E. Serum albumin is as efficient as paraxonase in the detoxication of paraoxon at toxicologically relevant concentrations. Chem Res Toxicol. 2008;21:1524-9 pubmed publisher
    ..These results explain why mice deficient in paraoxonase associated with lipoprotein are not more sensitive to paraoxon than wild animals. ..
  35. Forte T, Subbanagounder G, Berliner J, Blanche P, Clermont A, Jia Z, et al. Altered activities of anti-atherogenic enzymes LCAT, paraoxonase, and platelet-activating factor acetylhydrolase in atherosclerosis-susceptible mice. J Lipid Res. 2002;43:477-85 pubmed
    We examined whether the putative anti-atherogenic enzymes LCAT, paraoxonase (PON), and platelet-activating factor acetylhydrolase (PAF-AH) are impaired in 8 week old atherosclerosis susceptible apolipoprotein E (apoE)(-/-) and LDL ..
  36. Ng D, Chu T, Esposito B, Hui P, Connelly P, Gross P. Paraoxonase-1 deficiency in mice predisposes to vascular inflammation, oxidative stress, and thrombogenicity in the absence of hyperlipidemia. Cardiovasc Pathol. 2008;17:226-32 pubmed publisher
    ..We explored additional vascular changes in Pon1 knockout mice in the absence of atherogenic diet challenge...
  37. Saha A, Mazumder S. An aqueous extract of Murraya koenigii leaves induces paraoxonase 1 activity in streptozotocin induced diabetic mice. Food Funct. 2013;4:420-5 pubmed publisher
    Murraya koenigii (Mk) leaves possess a hypoglycemic effect. Activity of paraoxonase 1 (PON1), a HDL-associated antioxidant enzyme, was found to be decreased during hyperglycemia...
  38. Sorenson R, Primo Parmo S, Kuo C, Adkins S, Lockridge O, La Du B. Reconsideration of the catalytic center and mechanism of mammalian paraoxonase/arylesterase. Proc Natl Acad Sci U S A. 1995;92:7187-91 pubmed
    For three decades, mammalian paraoxonase (A-esterase, aromatic esterase, arylesterase; PON, EC 3.1.8...
  39. Eryanni Levin S, Khatib S, Levy Rosenzvig R, Tamir S, Szuchman Sapir A. 5,6-δ-DHTL, a stable metabolite of arachidonic acid, is a potential substrate for paraoxonase 1. Biochim Biophys Acta. 2015;1851:1118-22 pubmed publisher
    Paraoxonase 1 (PON1) is an antiatherogenic high density lipoprotein-associated lactonase...
  40. Aviram M, Rosenblat M. Paraoxonases (PON1, PON2, PON3) analyses in vitro and in vivo in relation to cardiovascular diseases. Methods Mol Biol. 2008;477:259-76 pubmed publisher
    ..All three members of the PON family (PON 1/2/3) were shown to protect from atherosclerosis development...
  41. bin Ali A, Zhang Q, Lim Y, Fang D, Retnam L, Lim S. Expression of major HDL-associated antioxidant PON-1 is gender dependent and regulated during inflammation. Free Radic Biol Med. 2003;34:824-9 pubmed
    ..However, serum PON-1 activity is highly variable and its regulation is complex, involving both genetic and environmental factors...
  42. Fuhrman B, Gantman A, Aviram M. Paraoxonase 1 (PON1) deficiency in mice is associated with reduced expression of macrophage SR-BI and consequently the loss of HDL cytoprotection against apoptosis. Atherosclerosis. 2010;211:61-8 pubmed publisher
    Paraoxonase 1 (PON1) was shown to stimulate HDL binding and HDL-mediated cholesterol efflux from macrophages. This study examined the role of PON1 in the expression of proteins that enhance macrophage HDL binding, i.e. ABCA1 and SR-BI...
  43. Kalyuzhny A, Hensleigh H, Arvidsson U, Elde R. Immunocytochemical localization of mu-opioid receptors in follicular cells and preimplantation mouse embryos. Anat Embryol (Berl). 1997;195:451-5 pubmed
    ..Embryonic opioid receptors may play a role in the regulation of preimplantation development and implantation. ..
  44. Oda M, Bielicki J, Ho T, Berger T, Rubin E, Forte T. Paraoxonase 1 overexpression in mice and its effect on high-density lipoproteins. Biochem Biophys Res Commun. 2002;290:921-7 pubmed
    Paraoxonase (PON1) is a high-density lipoprotein (HDL)-associated enzyme believed to protect against the early events of atherogenesis by its ability to hydrolyze oxidized phospholipids...
  45. Ono R, Nakamura K, Inoue K, Naruse M, Usami T, Wakisaka Saito N, et al. Deletion of Peg10, an imprinted gene acquired from a retrotransposon, causes early embryonic lethality. Nat Genet. 2006;38:101-6 pubmed
    ..This indicates that Peg10 is critical for mouse parthenogenetic development and provides the first direct evidence of an essential role of an evolutionarily conserved retrotransposon-derived gene in mammalian development...
  46. Efrat M, Aviram M. Macrophage paraoxonase 1 (PON1) binding sites. Biochem Biophys Res Commun. 2008;376:105-10 pubmed publisher
    Paraoxonase 1 (PON1), an HDL-associated esterase, is known to possess anti-oxidant and anti-atherogenic properties...
  47. Xu Y, Wang Y, Besnard V, Ikegami M, Wert S, Heffner C, et al. Transcriptional programs controlling perinatal lung maturation. PLoS ONE. 2012;7:e37046 pubmed publisher
    ..The present study systemically mapped key regulators, bioprocesses, and transcriptional networks controlling lung maturation, providing the basis for new therapeutic strategies to enhance lung function in preterm infants. ..
  48. Briquet Laugier V, Xia Y, Rooke K, Mehrabian M, Lusis A, Doolittle M. Mapping of three members of the mouse protein disulfide isomerase family. Mamm Genome. 1998;9:176-7 pubmed
  49. Reynolds S, Zemke A, Giangreco A, Brockway B, Teisanu R, Drake J, et al. Conditional stabilization of beta-catenin expands the pool of lung stem cells. Stem Cells. 2008;26:1337-46 pubmed publisher
    ..Our data demonstrate that the differentiation-modulating activities of stabilized beta-catenin account for expansion of tissue stem cells. ..
  50. Tavori H, Aviram M, Khatib S, Musa R, Mannheim D, Karmeli R, et al. Paraoxonase 1 protects macrophages from atherogenicity of a specific triglyceride isolated from human carotid lesion. Free Radic Biol Med. 2011;51:234-42 pubmed publisher
    ..LDLs, and oxidative stress (OS)-sensitive markers and inhibit the antiatherogenic enzyme paraoxonase 1 (PON1)...
  51. Rozenberg O, Rosenblat M, Coleman R, Shih D, Aviram M. Paraoxonase (PON1) deficiency is associated with increased macrophage oxidative stress: studies in PON1-knockout mice. Free Radic Biol Med. 2003;34:774-84 pubmed
    Human serum paraoxonase (PON1), an HDL-associated esterase, protects lipoproteins against oxidation, probably by hydrolyzing specific lipid peroxides...
  52. Yamashita J, Iwamura C, Ito T, Narita M, Hara Y, Sasaki T, et al. Paraoxonase-1 suppresses experimental colitis via the inhibition of IFN-? production from CD4 T cells. J Immunol. 2013;191:949-60 pubmed publisher
    ..We performed experiments to identify immunologically bioactive proteins in human plasma and found that paraoxonase (PON)-1, which has esterase activity and is associated with high-density lipoproteins, inhibited the IFN-? production by ..
  53. Rosenblat M, Gaidukov L, Khersonsky O, Vaya J, Oren R, Tawfik D, et al. The catalytic histidine dyad of high density lipoprotein-associated serum paraoxonase-1 (PON1) is essential for PON1-mediated inhibition of low density lipoprotein oxidation and stimulation of macrophage cholesterol efflux. J Biol Chem. 2006;281:7657-65 pubmed
    High density lipoprotein (HDL)-associated paraoxonase-1 (PON1) anti-atherogenic properties in macrophages, i.e...