Pomt2

Summary

Gene Symbol: Pomt2
Description: protein-O-mannosyltransferase 2
Alias: protein O-mannosyl-transferase 2, dolichyl-phosphate-mannose--protein mannosyltransferase 2
Species: mouse
Products:     Pomt2

Top Publications

  1. Lommel M, Willer T, Strahl S. POMT2, a key enzyme in Walker-Warburg syndrome: somatic sPOMT2, but not testis-specific tPOMT2, is crucial for mannosyltransferase activity in vivo. Glycobiology. 2008;18:615-25 pubmed publisher
    ..In mammals the protein O-mannosyltransferases POMT1 and POMT2 act as a heteromeric complex to initiate O-mannosylation in the endoplasmic reticulum...
  2. Li J, Yu M, Feng G, Hu H, Li X. Breaches of the pial basement membrane are associated with defective dentate gyrus development in mouse models of congenital muscular dystrophies. Neurosci Lett. 2011;505:19-24 pubmed publisher
    ..There are good mouse models for these CMDs that include POMGnT1 knockout, POMT2 knockout and Large(myd) mice with all exhibiting defects in dentate gyrus...
  3. Lommel M, Winterhalter P, Willer T, Dahlhoff M, Schneider M, Bartels M, et al. Protein O-mannosylation is crucial for E-cadherin-mediated cell adhesion. Proc Natl Acad Sci U S A. 2013;110:21024-9 pubmed publisher
    ..Our results redefine the significance of O-mannosylation in humans and other mammals, showing the immense impact of cadherins on normal as well as pathogenic cell behavior. ..
  4. Willer T, Amselgruber W, Deutzmann R, Strahl S. Characterization of POMT2, a novel member of the PMT protein O-mannosyltransferase family specifically localized to the acrosome of mammalian spermatids. Glycobiology. 2002;12:771-83 pubmed
    ..A detailed characterization of the mammalian POMT2, with emphasis on mouse Pomt2, shows that mammalian POMT2 is predominantly expressed in testis tissue...
  5. Prados B, Peña A, Cotarelo R, Valero M, Cruces J. Expression of the murine Pomt1 gene in both the developing brain and adult muscle tissues and its relationship with clinical aspects of Walker-Warburg syndrome. Am J Pathol. 2007;170:1659-68 pubmed
    ..This expression pattern in the testes could also be related to the gonadal anomalies observed in some patients with WWS. ..
  6. Hu H, Li J, Gagen C, Gray N, Zhang Z, Qi Y, et al. Conditional knockout of protein O-mannosyltransferase 2 reveals tissue-specific roles of O-mannosyl glycosylation in brain development. J Comp Neurol. 2011;519:1320-37 pubmed publisher
    ..To study the roles of O-mannosylation in brain development we generated a conditional allele of POMT2. POMT2 nulllizygosity resulted in embryonic lethality because of a defective Reichert's membrane...
  7. Yagi H, Nakagawa N, Saito T, Kiyonari H, Abe T, Toda T, et al. AGO61-dependent GlcNAc modification primes the formation of functional glycans on ?-dystroglycan. Sci Rep. 2013;3:3288 pubmed publisher
    ..These findings provide a key missing link for understanding how the physiologically critical glycan motif is displayed on ?-DG and provides new insights on the pathological mechanisms of dystroglycanopathy. ..