Pomc

Summary

Gene Symbol: Pomc
Description: pro-opiomelanocortin-alpha
Alias: ACTH, Beta-LPH, Clip, Gamma-LPH, Npp, Pomc-1, Pomc1, alpha-MSH, alphaMSH, beta-MSH, gamma-MSH, adrenal corticotropic hormone, adrenocorticotropic hormone, alpha-melanocyte stimulating hormone, beta-endorphin, corticotropin-like intermediary peptide, corticotropin-lipotropin, melanotropin gamma, met-enkephalin, pro-opiomelanocortin
Species: mouse

Top Publications

  1. ncbi The proopiomelanocortin gene is expressed as both full-length and 5'truncated transcripts in rodent Leydig cells
    R Ivell
    Institute for Hormone and Fertility Research, University of Hamburg, Germany
    Reprod Fertil Dev 6:791-4. 1994
  2. ncbi Endocrine response to surgical stress and postoperative confusion in depressed patients with alcohol abuse
    Akira Kudoh
    Department of Anesthesiology, Hirosaki National Hospital, Hirosaki, Aomori, Japan
    Neuropsychobiology 50:195-9. 2004
  3. pmc Identification of neuronal enhancers of the proopiomelanocortin gene by transgenic mouse analysis and phylogenetic footprinting
    Flavio S J de Souza
    INGEBI CONICET, Vuelta de Obligado 2490, 1428 Buenos Aires, Argentina
    Mol Cell Biol 25:3076-86. 2005
  4. ncbi Appropriate inhibition of orexigenic hypothalamic arcuate nucleus neurons independently of leptin receptor/STAT3 signaling
    Heike Munzberg
    Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Neurosci 27:69-74. 2007
  5. pmc Loss of agouti-related peptide does not significantly impact the phenotype of murine POMC deficiency
    Marcus P Corander
    University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Level 4, Addenbrooke s Hospital, Cambridge, UK
    Endocrinology 152:1819-28. 2011
  6. doi FoxO1 inhibits leptin regulation of pro-opiomelanocortin promoter activity by blocking STAT3 interaction with specificity protein 1
    Guoqing Yang
    Laboratory of Metabolic Medicine, Singapore Bioimaging Consortium, Agency for Science, Technology and Research, Singapore 138667
    J Biol Chem 284:3719-27. 2009
  7. pmc Noggin regulates Bmp4 activity during pituitary induction
    Shannon W Davis
    Department of Human Genetics, University of Michigan Medical School, 4909 Buhl Building, 1241 E Catherine St, Ann Arbor, MI 48109 0618, USA
    Dev Biol 305:145-60. 2007
  8. ncbi Inactivation of signal transducer and activator of transcription 3 in proopiomelanocortin (Pomc) neurons causes decreased pomc expression, mild obesity, and defects in compensatory refeeding
    Allison W Xu
    Department of Genetics, Stanford University School of Medicine, San Francisco, California 94143, USA
    Endocrinology 148:72-80. 2007
  9. pmc MicroRNAs regulate pituitary development, and microRNA 26b specifically targets lymphoid enhancer factor 1 (Lef-1), which modulates pituitary transcription factor 1 (Pit-1) expression
    Zichao Zhang
    Center for Environmental and Genetic Medicine, Institute of Biosciences and Technology, Texas A and M University Health Science Center, Houston, Texas 77030, USA
    J Biol Chem 285:34718-28. 2010
  10. pmc Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice
    Jennifer W Hill
    Division of Hypothalamic Research, Department of Internal Medicine and Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Clin Invest 118:1796-805. 2008

Scientific Experts

Detail Information

Publications101 found, 100 shown here

  1. ncbi The proopiomelanocortin gene is expressed as both full-length and 5'truncated transcripts in rodent Leydig cells
    R Ivell
    Institute for Hormone and Fertility Research, University of Hamburg, Germany
    Reprod Fertil Dev 6:791-4. 1994
    ..between full-length transcripts and functionally aberrant, truncated transcripts of the proopiomelanocortin (POMC) gene...
  2. ncbi Endocrine response to surgical stress and postoperative confusion in depressed patients with alcohol abuse
    Akira Kudoh
    Department of Anesthesiology, Hirosaki National Hospital, Hirosaki, Aomori, Japan
    Neuropsychobiology 50:195-9. 2004
    ..We investigated the incidence of postoperative confusion, plasma cortisol and ACTH response to surgical stress in depressed patients with alcohol abuse...
  3. pmc Identification of neuronal enhancers of the proopiomelanocortin gene by transgenic mouse analysis and phylogenetic footprinting
    Flavio S J de Souza
    INGEBI CONICET, Vuelta de Obligado 2490, 1428 Buenos Aires, Argentina
    Mol Cell Biol 25:3076-86. 2005
    The proopiomelanocortin (POMC) gene is expressed in the pituitary and arcuate neurons of the hypothalamus...
  4. ncbi Appropriate inhibition of orexigenic hypothalamic arcuate nucleus neurons independently of leptin receptor/STAT3 signaling
    Heike Munzberg
    Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Neurosci 27:69-74. 2007
    ..in s/s animals suggested that leptin appropriately suppresses the frequency of IPSCs on ARC proopiomelanocortin (POMC) neurons that are mediated by the release of GABA from orexigenic ARC neurons...
  5. pmc Loss of agouti-related peptide does not significantly impact the phenotype of murine POMC deficiency
    Marcus P Corander
    University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Level 4, Addenbrooke s Hospital, Cambridge, UK
    Endocrinology 152:1819-28. 2011
    ..is unique among neuropeptide systems controlling energy homeostasis, in that both anorexigenic proopiomelanocortin (POMC)-derived and orexigenic Agouti related-peptide (AgRP)-derived ligands act at the same receptors, namely ..
  6. doi FoxO1 inhibits leptin regulation of pro-opiomelanocortin promoter activity by blocking STAT3 interaction with specificity protein 1
    Guoqing Yang
    Laboratory of Metabolic Medicine, Singapore Bioimaging Consortium, Agency for Science, Technology and Research, Singapore 138667
    J Biol Chem 284:3719-27. 2009
    ..To understand the molecular mechanisms of leptin resistance, we studied the regulation of pro-opiomelanocortin (POMC) gene expression by leptin...
  7. pmc Noggin regulates Bmp4 activity during pituitary induction
    Shannon W Davis
    Department of Human Genetics, University of Michigan Medical School, 4909 Buhl Building, 1241 E Catherine St, Ann Arbor, MI 48109 0618, USA
    Dev Biol 305:145-60. 2007
    ..This work demonstrates the importance of attenuating the activity of Bmp signaling during pituitary induction in order to maintain the proper balance of signaling factors necessary for pituitary organogenesis...
  8. ncbi Inactivation of signal transducer and activator of transcription 3 in proopiomelanocortin (Pomc) neurons causes decreased pomc expression, mild obesity, and defects in compensatory refeeding
    Allison W Xu
    Department of Genetics, Stanford University School of Medicine, San Francisco, California 94143, USA
    Endocrinology 148:72-80. 2007
    ..by acting on multiple neuronal subgroups in the hypothalamus, including those that express proopiomelanocortin (Pomc) and agouti-related protein (Agrp)...
  9. pmc MicroRNAs regulate pituitary development, and microRNA 26b specifically targets lymphoid enhancer factor 1 (Lef-1), which modulates pituitary transcription factor 1 (Pit-1) expression
    Zichao Zhang
    Center for Environmental and Genetic Medicine, Institute of Biosciences and Technology, Texas A and M University Health Science Center, Houston, Texas 77030, USA
    J Biol Chem 285:34718-28. 2010
    ..This study demonstrates that microRNAs are critical for anterior pituitary development and that miR-26b regulates Pit-1 expression by inhibiting Lef-1 expression and may promote Pit-1 lineage differentiation during pituitary development...
  10. pmc Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice
    Jennifer W Hill
    Division of Hypothalamic Research, Department of Internal Medicine and Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Clin Invest 118:1796-805. 2008
    ..food intake and body weight homeostasis require the direct action of leptin on hypothalamic proopiomelanocortin (POMC) neurons. It has been proposed that leptin action requires PI3K activity...
  11. ncbi Specification of pituitary cell lineages by the LIM homeobox gene Lhx3
    H Z Sheng
    Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Science 272:1004-7. 1996
    ..The determination of all pituitary cell lineages, except the corticotrophs, was affected, suggesting that a distinct, Lhx3-independent ontogenetic pathway exists for the initial specification of this lineage...
  12. pmc Spatial and temporal localization of the melanocortin 1 receptor and its ligand α-melanocyte-stimulating hormone during cutaneous wound repair
    Lara A Muffley
    Department of Surgery, University of Washington, Seattle, Washington 98104, USA
    J Histochem Cytochem 59:278-88. 2011
    ..This article contains online supplemental material at http://www.jhc.org. Please visit this article online to view these materials...
  13. pmc Mechanisms underlying pituitary hypoplasia and failed cell specification in Lhx3-deficient mice
    Buffy S Ellsworth
    Department of Human Genetics, The University of Michigan, Medical School, 4909 Buhl Bldg, Ann Arbor, MI 48109 0618, USA
    Dev Biol 313:118-29. 2008
    ....
  14. doi Prenylated Rab acceptor domain family member 1 is involved in stimulated ACTH secretion and inhibition
    Shannon L Compton
    Pioneer Valley Life Sciences Institute, Springfield, MA 01199, United States
    Cell Signal 21:1901-9. 2009
    ..to corticotrophin-releasing hormone and Dex, upregulated expression of the ACTH prohormone pro-opiomelanocortin (POMC), altered POMC processing, and altered Golgi complex morphology with decreased intra-Golgi and intracellular co-..
  15. pmc Use of mutant mouse lines to investigate origin of gonadotropin-releasing hormone-1 neurons: lineage independent of the adenohypophysis
    Hillery Metz
    Cellular and Developmental Neurobiology Section, National Institute of Neurological Disorder and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Endocrinology 151:766-73. 2010
    ..These results indicate that in mice, GnRH-1 cells develop independent of the adenohypophyseal placode and are associated early with the formation of the nasal placode...
  16. ncbi Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin
    L Yaswen
    Unit on Molecular Genetics, Clinical Neuroscience Branch, NIMH, 49 Convent Drive, Bethesda, Maryland 20892, USA
    Nat Med 5:1066-70. 1999
    Pro-opiomelanocortin (POMC)-derived peptides (the melanocortins adrenocorticotropin, alpha-, beta- and gamma-melanocyte stimulating hormone; and the endogenous opioid beta-endorphin) have a diverse array of biological activities, ..
  17. ncbi Nur77 induction and activation are necessary for interleukin-1 stimulation of proopiomelanocortin in AtT-20 corticotrophs
    Damian Kovalovsky
    Departamento de Fisiologia y Biologia Molecular, FCEN, Universidad de Buenos Aires and CONICET, Buenos Aires, Argentina
    FEBS Lett 563:229-33. 2004
    Nur77 and Nurr1 are critical for proopiomelanocortin (POMC) regulation by corticotrophin releasing hormone (CRH) in corticotrophs...
  18. ncbi In vivo evidence for inverse agonism of Agouti-related peptide in the central nervous system of proopiomelanocortin-deficient mice
    Virginie Tolle
    Center for the Study of Weight Regulation and Associated Disorders, Oregon Health and Science University, Portland, Oregon, USA
    Diabetes 57:86-94. 2008
    Melanocyte-stimulating hormone (MSH) peptides processed from proopiomelanocortin (POMC) regulate energy homeostasis by activating neuronal melanocortin receptor (MC-R) signaling...
  19. ncbi PITX genes are required for cell survival and Lhx3 activation
    Michael A Charles
    4301 MSRB III, 1500 West Medical Center Drive, University of Michigan Medical School, Ann Arbor, MI 48109 0638, USA
    Mol Endocrinol 19:1893-903. 2005
    ..Thus, the combined dosage of these PITX family members is vital for pituitary development, and their persistent coexpression in the adult pituitary suggests a continued role in maintenance of pituitary function...
  20. ncbi FOXL2 in the pituitary: molecular, genetic, and developmental analysis
    Buffy S Ellsworth
    The University of Michigan Medical School, 4909 Buhl Building, Ann Arbor, Michigan 48109 0618, USA
    Mol Endocrinol 20:2796-805. 2006
    ..These data place FOXL2 in the hierarchy of pituitary developmental control and suggest a role in regulation of Cga gene expression...
  21. pmc Peripheral administration of the N-terminal pro-opiomelanocortin fragment 1-28 to Pomc-/- mice reduces food intake and weight but does not affect adrenal growth or corticosterone production
    Anthony P Coll
    Departments of Clinical Biochemistry and Medicine, Cambridge Institute for Medical Research, Addenbrooke s Hospital, Cambridge CB2 2XY, UK
    J Endocrinol 190:515-25. 2006
    Pro-opiomelanocortin (POMC) is a polypeptide precursor that undergoes extensive processing to yield a range of peptides with biologically diverse functions...
  22. ncbi Proopiomelanocortin-deficient mice are hypersensitive to the adverse metabolic effects of glucocorticoids
    Anthony P Coll
    University Department of Medicine, Addenbrooke s Hospital, Cambridge CB2 2QR, UK
    Diabetes 54:2269-76. 2005
    Congenital lack of proopiomelanocortin (POMC) causes obesity and glucocorticoid deficiency. The responses of Pomc-/- and wild-type mice to the administration of corticosterone were compared...
  23. pmc Glucocorticoids exacerbate obesity and insulin resistance in neuron-specific proopiomelanocortin-deficient mice
    James L Smart
    Vollum Institute, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Clin Invest 116:495-505. 2006
    Null mutations of the proopiomelanocortin gene (Pomc) cause obesity in humans and rodents, but the contributions of central versus pituitary POMC deficiency are not fully established...
  24. ncbi The effects of proopiomelanocortin deficiency on murine adrenal development and responsiveness to adrenocorticotropin
    Anthony P Coll
    Department of Medicine, Box 232, Addenbrooke s Hospital, Cambridge CB2 2QR, United Kingdom
    Endocrinology 145:4721-7. 2004
    The mature adrenal cortex is dependent upon proopiomelanocortin (POMC)-derived peptides for the maintenance of its size, structure, and endocrine function...
  25. doi PDK-1/FoxO1 pathway in POMC neurons regulates Pomc expression and food intake
    Kristy Iskandar
    International Center for Medical Research and Treatment, Kobe University Graduate School of Medicine, Japan
    Am J Physiol Endocrinol Metab 298:E787-98. 2010
    ..protein kinase-1 (PDK-1)/protein kinase B (PKB, also known as Akt) in proopiomelanocortin (POMC) neurons. Forkhead box-containing protein-O1 (FoxO1) is inactivated in a PI(3)K-dependent manner...
  26. ncbi TCF and Groucho-related genes influence pituitary growth and development
    Michelle L Brinkmeier
    Department of Human Genetics, University of Michigan Medical School, 4301 MSRBIII, Ann Arbor, Michigan 48109 0638, USA
    Mol Endocrinol 17:2152-61. 2003
    ..Thus, we demonstrate that Tcf4 and Aes influence pituitary growth and development, and place Tcf4 and Tle3 in the genetic hierarchy with Prop1...
  27. ncbi Expression of syndecan-1 inhibits cell invasion into type I collagen
    B F Liebersbach
    Department of Pathology, University of Arkansas for Medical Sciences, Little Rock 72205
    J Biol Chem 269:20013-9. 1994
    ..These results demonstrate that expression of syndecan-1 inhibits cell invasion into collagen and that loss of syndecan-1 expression may be necessary prior to the migration of normal or metastatic cells...
  28. ncbi Characterization of glucosensing neuron subpopulations in the arcuate nucleus: integration in neuropeptide Y and pro-opio melanocortin networks?
    Xavier Fioramonti
    Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5018, Paul Sabatier University, Toulouse, France
    Diabetes 56:1219-27. 2007
    ..in glucose-inhibited neurons and the neurotransmitter identity (neuropeptide Y [NPY] or pro-opio melanocortin [POMC]) of glucosensing neurons has remained controversial...
  29. pmc A comparative study of the central effects of specific proopiomelancortin (POMC)-derived melanocortin peptides on food intake and body weight in pomc null mice
    Y C Loraine Tung
    Department of Clinical Biochemistry, Cambridge Institute for Medical Research, Addenbrooke s Hospital, Cambridge CB2 2QR, United Kingdom
    Endocrinology 147:5940-7. 2006
    ..The ligands for these receptors are derived from the prohormone proopiomelancortin (POMC), which is posttranslationally processed to produce a set of melanocortin peptides with a range of activities at ..
  30. ncbi Altered midline axon pathways and ectopic neurons in the developing hypothalamus of netrin-1- and DCC-deficient mice
    M S Deiner
    Departments of Ophthalmology and Physiology, Biomedical Sciences Program, Beckman Vision Center, University of California, San Francisco, San Francisco, California 94143 0730, USA
    J Neurosci 19:9900-12. 1999
    ..Netrin protein localization also indicates that unlike in more caudal CNS, guidance about the hypothalamic ventral midline does not require midline expression of netrin...
  31. ncbi Adrenalectomy reverses obese phenotype and restores hypothalamic melanocortin tone in leptin-deficient ob/ob mice
    H Makimura
    Fishberg Center for Neurobiology, Department of Geriatrics, Mount Sinai School of Medicine, New York, New York, USA
    Diabetes 49:1917-23. 2000
    ..Relative to lean controls, ob/ob mice also exhibit decreased hypothalamic proopiomelanocortin (POMC) mRNA and increased hypothalamic agouti-related peptide (AGRP) mRNA and neuropeptide Y (NPY) mRNA...
  32. pmc N-acetylation of hypothalamic alpha-melanocyte-stimulating hormone and regulation by leptin
    Li Guo
    Division of Endocrinology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 101:11797-802. 2004
    ..The POMC-derived peptide alpha-melanocyte-stimulating hormone (alphaMSH) is a melanocortin 4 receptor agonist, and its potency in reducing energy intake is strongly increased by N-..
  33. ncbi Targeted ablation of pituitary pre-proopiomelanocortin cells by herpes simplex virus-1 thymidine kinase differentially regulates mRNAs encoding the adrenocorticotropin receptor and aldosterone synthase in the mouse adrenal gland
    R G Allen
    Center for Research on Occupational and Environmental Toxicology, Vollum Institute, Oregon Health Sciences University, Portland 97201, USA
    Mol Endocrinol 9:1005-16. 1995
    ..of transgenic mice expressing a fusion gene composed of the pituitary expression-specific promoter region of the POMC gene, driving the herpes simplex viral-1 thymidine kinase...
  34. ncbi Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism
    M W Sornson
    Howard Hughes Medical Institute, University of California at San Diego, La Jolla 92093, USA
    Nature 384:327-33. 1996
    ..These results imply that a cascade of tissue-specific regulators is responsible for the determination and differentiation of specific cell lineages in pituitary organogenesis...
  35. pmc Multistep signaling requirements for pituitary organogenesis in vivo
    M Treier
    Howard Hughes Medical Institute, University of California, San Diego, School and Department of Medicine, La Jolla, California 92093 0648 USA
    Genes Dev 12:1691-704. 1998
    ....
  36. pmc Mice lacking pro-opiomelanocortin are sensitive to high-fat feeding but respond normally to the acute anorectic effects of peptide-YY(3-36)
    B G Challis
    Department of Clinical Biochemistry and Medicine, Cambridge Institute for Medical Research, Addenbrookes Hospital, Cambridge CB2 2XY, United Kingdom
    Proc Natl Acad Sci U S A 101:4695-700. 2004
    Inactivating mutations of the pro-opiomelanocortin (POMC) gene in both mice and humans leads to hyperphagia and obesity...
  37. ncbi UV-induced expression of key component of the tanning process, the POMC and MC1R genes, is dependent on the p-38-activated upstream stimulating factor-1 (USF-1)
    Sébastien Corre
    CNRS UMR 6061 Laboratoire de Génétique et Développement, Faculte de Medecine, Universite de Rennes 1, 2 Avenue du Pr Leon Bernard, 35043 Rennes, France
    J Biol Chem 279:51226-33. 2004
    ..A key component of the tanning process is the UV-mediated induction of the pro-opiomelanocortin (POMC) and MC1R genes encoding the alpha-melanocyte-stimulating hormone and its receptor, respectively, which play a ..
  38. pmc Feedback control of glucocorticoid production is established during fetal development
    H M Reichardt
    Division Molecular Biology of the Cell I, German Cancer Research Center, Heidelberg, Germany
    Mol Med 2:735-44. 1996
    ....
  39. ncbi Adrenocorticotropic hormone-mediated signaling cascades coordinate a cyclic pattern of steroidogenic factor 1-dependent transcriptional activation
    Jonathon N Winnay
    Department of Molecular and Integrative Pysiology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0678, USA
    Mol Endocrinol 20:147-66. 2006
    ..Within the adrenal cortex, ACTH-dependent transcriptional responses, including transcriptional activation of several key steroidogenic enzymes ..
  40. pmc Rax is a selector gene for mediobasal hypothalamic cell types
    Fuqu Lu
    Department of Medical Genetics, Alberta Children s Hospital Research Institute, University of Calgary, Calgary, Alberta T2N 4N1, Canada
    J Neurosci 33:259-72. 2013
    ..Rax thus provides a molecular entry point for further study of the ontology and establishment of hypothalamic feeding circuits...
  41. pmc Embryonic gonadotropin-releasing hormone signaling is necessary for maturation of the male reproductive axis
    Shuping Wen
    Institute for Neural Signal Transduction, Center for Molecular Neurobiology, D 20253 Hamburg, Germany
    Proc Natl Acad Sci U S A 107:16372-7. 2010
    ..Our experiments define a functional role of embryonic GnRH signaling...
  42. pmc Proopiomelanocortin (POMC) expression and conditioned place aversion during protracted withdrawal from chronic intermittent escalating-dose heroin in POMC-EGFP promoter transgenic mice
    K Niikura
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Neuroscience 236:220-32. 2013
    ..Here, we investigate changes in proopiomelanocortin (POMC) expression at three time points across an extended period of heroin withdrawal in a clinically relevant rodent ..
  43. ncbi Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity
    Laura E Parton
    Department of Medicine, Division of Endocrinology, Beth Israel Deaconess Medical Center and Harvard Medical School, 99 Brookline Avenue, Boston, Massachusetts 02215, USA
    Nature 449:228-32. 2007
    ..To address these issues, we disrupted glucose sensing in glucose-excited pro-opiomelanocortin (POMC) neurons via transgenic expression of a mutant Kir6...
  44. pmc Peripheral mechanisms contributing to the glucocorticoid hypersensitivity in proopiomelanocortin null mice treated with corticosterone
    Zoi Michailidou
    Endocrine Unit, Queen s Medical Research Institute, Centre for Cardiovascular Sciences, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    J Endocrinol 194:161-70. 2007
    Proopiomelanocortin (POMC) deficiency causes severe obesity through hyperphagia of hypothalamic origin...
  45. ncbi Transcriptional regulation of pituitary POMC is conserved at the vertebrate extremes despite great promoter sequence divergence
    Viviana F Bumaschny
    Instituto de Investigaciones en Ingenieria Genetica y Biologia Molecular, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Buenos Aires, Argentina
    Mol Endocrinol 21:2738-49. 2007
    ..Key mediators of the stress response are pituitary hormones encoded by the proopiomelanocortin gene (POMC)...
  46. pmc Melanocortin 2 receptor is required for adrenal gland development, steroidogenesis, and neonatal gluconeogenesis
    Dai Chida
    Division of Cell Biology, Center for Experimental Medicine, and Fine Morphology Laboratory, Department of Basic Medical Science, Institute of Medical Science, University of Tokyo, 4 6 1, Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Proc Natl Acad Sci U S A 104:18205-10. 2007
    b>ACTH (i.e., corticotropin) is the principal regulator of the hypothalamus-pituitary-adrenal axis and stimulates steroidogenesis in the adrenal gland via the specific cell-surface melanocortin 2 receptor (MC2R)...
  47. doi Apelin and the proopiomelanocortin system: a new regulatory pathway of hypothalamic α-MSH release
    Annabelle Reaux-Le Goazigo
    Institut National de Santé et de Recherche Médicale, Unité Mixte de Recherche S 691, Centre for Interdisciplinary Research in Biology, College de France, and Université Pierre et Marie Curie Paris 6, Paris, France
    Am J Physiol Endocrinol Metab 301:E955-66. 2011
    ..neuropeptide Y (NPY)-producing neurons stimulate food intake, whereas neurons releasing the proopiomelanocortin (POMC)-derived peptide α-melanocyte-stimulating hormone (α-MSH) strongly decrease food intake...
  48. pmc Deficiency of PTP1B in POMC neurons leads to alterations in energy balance and homeostatic response to cold exposure
    Bart C De Jonghe
    Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Physiol Endocrinol Metab 300:E1002-11. 2011
    ..leptin regulates energy balance through catabolic effects on central circuits, including proopiomelanocortin (POMC) neurons. Leptin activation of POMC neurons increases thermogenesis and locomotor activity...
  49. pmc Birthdating studies reshape models for pituitary gland cell specification
    Shannon W Davis
    Department of Human Genetics, University of Michigan Medical School, 4909 Buhl Building, 1241 East Catherine Street, Ann Arbor, MI 48109 5618, USA
    Dev Biol 352:215-27. 2011
    ..We propose that signals intrinsic to Rathke's pouch are necessary for cell specification between e11.5 and e13.5 and that cell-cell communication likely plays an important role in regulating this process...
  50. doi Genetic modifications of mouse proopiomelanocortin peptide processing
    Jessica L Costa
    Department of Medicine, University of Auckland, Auckland, New Zealand
    Mol Cell Endocrinol 336:14-22. 2011
    Pro-opiomelanocortin (POMC) is a prohormone which undergoes extensive tissue and cell specific post-translational processing producing a number of active peptides with diverse biological roles ranging from control of adrenal function to ..
  51. pmc An intrinsic gut leptin-melanocortin pathway modulates intestinal microsomal triglyceride transfer protein and lipid absorption
    Jahangir Iqbal
    Department of Cell Biology and Pediatrics, State University of New York Health Science Center at Brooklyn SUNY Downstate Medical Center, Brooklyn, NY, USA
    J Lipid Res 51:1929-42. 2010
    ..Mice with spontaneous LEPR B mutations or targeted ablation of LEPR B in proopiomelanocortin (POMC) or agouti gene related peptide (AGRP) expressing cells had increased triglyceride in plasma, liver, and intestine...
  52. pmc PTP1B and SHP2 in POMC neurons reciprocally regulate energy balance in mice
    Ryoichi Banno
    Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104 6046, USA
    J Clin Invest 120:720-34. 2010
    ..Interestingly, hypothalamic Pomc mRNA and alpha-melanocyte-stimulating hormone (alphaMSH) peptide levels were markedly reduced in POMC-Shp2-/- mice...
  53. pmc Corticotropin and beta-endorphin: construction and analysis of recombinant DNA complementary to mRNA for the common precursor
    J L Roberts
    Proc Natl Acad Sci U S A 76:2153-7. 1979
    A cDNA fragment synthesized from mouse mRNA (ACTH/LPH mRNA) that codes for the precursor polypeptide containing corticotropin (ACTH), beta-lipotropin (LPH), and several other peptides has been cloned in bacteria...
  54. pmc A potential role for hypothalamomedullary POMC projections in leptin-induced suppression of food intake
    Huiyuan Zheng
    Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, USA
    Am J Physiol Regul Integr Comp Physiol 298:R720-8. 2010
    ..nucleus of the hypothalamus and the nucleus of the solitary tract (NTS) harbor populations of proopiomelanocortin (POMC)-expressing neurons...
  55. pmc {alpha}MSH and Cyclic AMP elevating agents control melanosome pH through a protein kinase A-independent mechanism
    Yann Cheli
    From INSERM, U895, Centre Méditerranéen de Médecine Moléculaire C3M, Equipe 1, Biology and Pathologies of Melanocytes, F 06204 Nice Cedex 3, France
    J Biol Chem 284:18699-706. 2009
    ..In the present study, we show that the activation of the cAMP pathway by alphaMSH or forskolin leads to an alkalinization of melanosomes and a concomitant regulation of vacuolar ATPases and ion ..
  56. pmc Nicotine anxiogenic and rewarding effects are decreased in mice lacking beta-endorphin
    Jose M Trigo
    Laboratori de Neurofarmacologia, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain
    Neuropharmacology 56:1147-53. 2009
    ..The dissociation between nicotine rewarding properties and physical dependence suggests a differential implication of beta-endorphin in these addictive related responses...
  57. pmc Analysis of mouse models carrying the I26T and R160C substitutions in the transcriptional repressor HESX1 as models for septo-optic dysplasia and hypopituitarism
    Ezat Sajedi
    Neural Development Unit, Institute of Child Health, University College London, London, UK
    Dis Model Mech 1:241-54. 2008
    ..Together, these results suggest that the I26T mutation yields a hypomorphic allele, whereas R160C produces a null allele and, consequently, a more severe phenotype in both mice and humans...
  58. doi Involvement of nuclear factor-kB and Nurr-1 in cytokine-induced transcription of proopiomelanocortin gene in AtT20 corticotroph cells
    Shinobu Takayasu
    Department of Endocrinology and Metabolism, Hirosaki University School of Medicine, Hirosaki, Japan
    Neuroimmunomodulation 17:88-96. 2010
    ..We examined whether transcription factors nuclear factor (NF)-kappaB and Nurr-1 are involved in the cytokine-induced proopiomelanocortin (POMC) gene expression.
  59. doi Novel modulators for body weight changes induced by fasting and re-feeding in mice
    Katsunori Nonogaki
    Center of Excellence, Division of Molecular Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Japan
    Biochem Biophys Res Commun 378:249-54. 2009
    ..Thus, social isolation, endogenous beta-endorphin, and age can be novel modulators for body weight changes induced by fasting and re-feeding in mice...
  60. doi Corticotropin-releasing factor (CRF) is involved in the acute anorexic effect of alpha-melanocyte-stimulating hormone: a study using CRF-deficient mice
    Shoko Kawashima
    Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki, Aomori 036 8562, Japan
    Peptides 29:2169-74. 2008
    ..The results would suggest that alpha-MSH-induced suppression of food intake at late phase was independent of glucocorticoids and CRF...
  61. doi Failure of adrenal corticosterone production in POMC-deficient mice results from lack of integrated effects of POMC peptides on multiple factors
    Jason Karpac
    Department of Neurobiology, Duke University Medical Center, 421 Research Drive, Durham, NC 27710, USA
    Am J Physiol Endocrinol Metab 295:E446-55. 2008
    ..The main hormone regulating the production of corticosterone is the proopiomelanocortin (POMC)-derived adrenocorticotropic hormone (ACTH)...
  62. pmc A model for obesity and gigantism due to disruption of the Ankrd26 gene
    Tapan K Bera
    Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 4264, USA
    Proc Natl Acad Sci U S A 105:270-5. 2008
    ..These results show that alterations in an unidentified gene can lead to obesity and identify a molecular target for the treatment of obesity...
  63. doi Loss of the protein NUPR1 (p8) leads to delayed LHB expression, delayed ovarian maturation, and testicular development of a sertoli-cell-only syndrome-like phenotype in mice
    Christina M Million Passe
    Medical Sciences Program, Indiana University School of Medicine, Bloomington, Indiana 47405, USA
    Biol Reprod 79:598-607. 2008
    ..Therefore, the ovarian and testicular phenotypes may be due to the loss of NUPR1 directly at the gonads...
  64. ncbi Altered estrogenic modulation of hypothalamic proopiomelanocortin gene expression in aging mice
    J F Nelson
    Department of Physiology, University of Texas Health Science Center, San Antonio 78284 7756
    Ann N Y Acad Sci 663:501-4. 1992
  65. ncbi State-dependent modulation of feeding behavior by proopiomelanocortin-derived beta-endorphin
    Malcolm J Low
    Vollum Institute, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    Ann N Y Acad Sci 994:192-201. 2003
    ..the opioid peptide beta-endorphin is co-synthesized and released with melanocortins from proopiomelanocortin (POMC) neuronal terminals, we examined the physiological role of beta-endorphin in feeding and energy homeostasis using a ..
  66. ncbi Mechanism of sorting proopiomelanocortin and proenkephalin to the regulated secretory pathway of neuroendocrine cells
    Y Peng Loh
    Section on Cellular Neurobiology, Laboratory of Developmental Biology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Ann N Y Acad Sci 971:416-25. 2002
    Proopiomelanocortin (POMC) and proenkephalin (PE) are synthesized at the endoplasmic reticulum and transported to the trans-Golgi network (TGN) where they are sorted and packaged into dense-core granules of the regulated secretory pathway ..
  67. ncbi Pitx2 is required at multiple stages of pituitary organogenesis: pituitary primordium formation and cell specification
    Hoonkyo Suh
    Neuroscience Program, Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109 0638, USA
    Development 129:329-37. 2002
    ..The model developed for PITX gene function in pituitary development provides a better understanding of the etiology of Rieger syndrome and may extend to other PITX-sensitive developmental processes...
  68. ncbi Rapid communication: Mapping of the pro-opiomelanocortin (POMC) gene to pig chromosome by linkage analysis using a PCR-RFLP
    L A Messer
    Department of Animal Science, University of Nebraska, Lincoln 68583 0908, USA
    J Anim Sci 79:2241-2. 2001
  69. ncbi Characterization of the cDNA and gene for mouse tumour necrosis factor alpha converting enzyme (TACE/ADAM17) and its location to mouse chromosome 12 and human chromosome 2p25
    D P Cerretti
    Immunex Corporation, 51 University St, Seattle, WA, 98101, USA
    Cytokine 11:541-51. 1999
    ..The gene for TACE/ADAM17 is approximately 50 kb and contains 19 exons. Chromosomal mapping places TACE/ADAM17 on mouse chromosome 12 and human chromosome 2p25...
  70. ncbi Motor and learning dysfunction during postnatal development in mice defective in dopamine neuronal transmission
    K Nishii
    Institute for Comprehensive Medical Science, School of Medicine, Fujita Health University, Toyoake, Aichi, Japan
    J Neurosci Res 54:450-64. 1998
    ..These results demonstrate that dopamine neurotransmission is essential for controlling spontaneous and voluntary movement and associative learning during postnatal development through the nigrostriatal and mesocorticolimbic pathways...
  71. ncbi Involvement of microphthalmia in the inhibition of melanocyte lineage differentiation and of melanogenesis by agouti signal protein
    E Aberdam
    INSERM U385, Biologie et Physiopathologie de la Peau, Faculte de Medecine, 06107 Nice Cedex 2, France
    J Biol Chem 273:19560-5. 1998
    ..of two intercellular signaling molecules that exert opposite actions, alpha-melanocyte-stimulating hormone (alphaMSH) which preferentially increases the synthesis of eumelanins, and agouti signal protein (ASP) whose expression ..
  72. ncbi Obesity, diabetes and functions for proopiomelanocortin-derived peptides
    K G Mountjoy
    Research Centre for Developmental Medicine and Biology, Department of Paediatrics, University of Auckland, New Zealand
    Mol Cell Endocrinol 128:171-7. 1997
    ..and gamma-melanocyte stimulating hormone (MSH), and fragments thereof) derived from proopiomelanocortin (POMC) have a diverse array of biological activities, many of which have yet to be fully elucidated...
  73. ncbi Targeted ablation of cells in the pituitary primordia of transgenic mice
    H L Burrows
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor 48109 0618, USA
    Mol Endocrinol 10:1467-77. 1996
    ..In spite of the absence of gonadotropes and thyrotropes, the GH and ACTH-producing cells developed normally...
  74. ncbi Ptx1, a bicoid-related homeo box transcription factor involved in transcription of the pro-opiomelanocortin gene
    T Lamonerie
    Laboratoire de Genetique Moleculaire, Institut de Recherches Cliniquesde Montréal, Quebec, Canada
    Genes Dev 10:1284-95. 1996
    ..The first cells to differentiate are those that express the pro-opiomelanocortin (POMC) gene in the anterior pituitary lobe...
  75. ncbi Alpha-melanocyte-stimulating hormone is a peripheral, integrative regulator of glucose and fat metabolism
    Miles B Brennan
    Eleanor Roosevelt Institute for Cancer Research, Denver, Colorado 80206, USA
    Ann N Y Acad Sci 994:282-7. 2003
    ..of glucose and insulin, we investigated the nature of glucose homeostasis in the obese pro-opiomelanocortin (POMC) knockout mouse...
  76. ncbi The involvement of the nociceptin receptor in the antinociceptive action of nitrous oxide
    Shugaku Himukashi
    Department of Anesthesia, Kyoto University Hospital, Kyoto, Japan
    Anesth Analg 103:738-41. 2006
    ..and nitrous oxide (70%), intraperitoneal injection of acetic acid resulted in an increase of plasma adrenocorticotropic hormone concentrations in NOP-/- mice but not in NOP+/+ mice...
  77. ncbi Cell proliferation and vascularization in mouse models of pituitary hormone deficiency
    Robert D Ward
    Graduate Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor 48109 0618, USA
    Mol Endocrinol 20:1378-90. 2006
    ..This suggests that Prop1 and/or Pit1 may be necessary for caspase-3 expression. These studies provide further insight as to the mechanisms of Prop1 and Pit1 action in mice...
  78. ncbi Control of ACTH secretion by excitatory amino acids: functional significance and clinical implications
    Daniela Jezova
    Laboratory of Pharmacological Neuroendocrinology, Institute of Experimental Endocrinology, Slovak Academy of Sciences, Vlarska 3, Bratislava 83306, Slovakia
    Endocrine 28:287-94. 2005
    The involvement of excitatory amino acids in the control of ACTH release is well established...
  79. pmc The vasopressin V1b receptor critically regulates hypothalamic-pituitary-adrenal axis activity under both stress and resting conditions
    Akito Tanoue
    Department of Molecular, Cell Pharmacology, National Research Institute for Child Health and Development, Tokyo, Japan
    J Clin Invest 113:302-9. 2004
    ..receptor is specifically expressed in pituitary corticotrophs and mediates the stimulatory effect of vasopressin on ACTH release...
  80. ncbi Rabphilin localizes with the cell actin cytoskeleton and stimulates association of granules with F-actin cross-linked by {alpha}-actinin
    Giovanna Baldini
    Dipartimento di Morfologia Umana Normale, Via Manzoni 16, Trieste, Universita di Trieste, Trieste I 34138, Italy
    J Biol Chem 280:34974-84. 2005
    ..These results suggest that rabphilin, by interacting with alpha-actinin, organizes the cell cytoskeleton to facilitate granule localization within F-actin-rich regions...
  81. ncbi The contribution of endogenous opioids to food reward is dependent on sex and background strain
    M D Hayward
    Center for the Study of Weight Regulation, Oregon Health and Science University, 3181 Southwest Sam Jackson Park Road, Portland, OR 97239, USA
    Neuroscience 144:17-25. 2007
    ....
  82. ncbi Altered glucose homeostasis in proopiomelanocortin-null mouse mutants lacking central and peripheral melanocortin
    Ute Hochgeschwender
    Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104
    Endocrinology 144:5194-202. 2003
    ..We tested this in a mouse model where the proopiomelanocortin (POMC) gene encoding all of the melanocortins has been genetically deleted...
  83. pmc Ontogeny of the prohormone convertases PC1 and PC2 in the mouse hypophysis and their colocalization with corticotropin and alpha-melanotropin
    M Marcinkiewicz
    J A DeSève Laboratory of Biochemical Neuroendocrinology, Clinical Research Institute of Montreal, Quebec, Canada
    Proc Natl Acad Sci U S A 90:4922-6. 1993
    ..corticotrophs, POMC is processed mainly to corticotropin (ACTH) and beta-lipotropin, while alpha-melanotropin (alpha MSH) and beta-endorphin are the major end products in the melanotrophs...
  84. ncbi In situ hybridization analysis of anterior pituitary hormone gene expression during fetal mouse development
    M A Japón
    Vollum Institute for Advanced Biomedical Research, Oregon Health Sciences University, Portland
    J Histochem Cytochem 42:1117-25. 1994
    ..5 (E9.5) to postnatal Day 1 (P1). Pro-opiomelanocortin (POMC) mRNA was expressed in the basal diencephalon on Day E10...
  85. pmc Pax6 is essential for establishing ventral-dorsal cell boundaries in pituitary gland development
    C Kioussi
    Howard Hughes Medical Institute, University of California San Diego, School, Department of Medicine, 9500 Gilman Drive, Cellular and Molecular Medicine Room 345, La Jolla, CA 92093 0648, USA
    Proc Natl Acad Sci U S A 96:14378-82. 1999
    ..We suggest that the transient dorsal expression of Pax6 is essential for establishing a sharp boundary between dorsal and ventral cell types, based on the inhibition of Shh ventral signals...
  86. ncbi Detection and quantitation of pro-opiomelanocortin mRNA in pituitary and brain tissues from different species
    O Civelli
    J Biol Chem 257:6783-7. 1982
    ..These results support the hypothesis that adrenocorticotropic hormone/endorphin peptides previously detected in the hypothalamus and amygdala with immunological techniques ..
  87. ncbi Localization of the muscle, liver, and brain glycogen phosphorylase genes on linkage maps of mouse chromosomes 19, 12, and 2, respectively
    T Glaser
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139
    Genomics 5:510-21. 1989
    ..However, muscle phosphorylase gene structure and expression appear to be unaltered in mdf/mdf mice, indicating that this mutation is not an animal model for the human genetic disorder McArdle's disease...
  88. pmc Id proteins Id1 and Id2 selectively inhibit DNA binding by one class of helix-loop-helix proteins
    X H Sun
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142
    Mol Cell Biol 11:5603-11. 1991
    ..E47 and E2B.m3, but not that of the other set, including TFE3, USF, and AP4. The Id proteins also homodimerize poorly. Expression of both Id genes is down-regulated during differentiation in a variety of cell types...
  89. pmc Identification of DNA elements cooperatively activating proopiomelanocortin gene expression in the pituitary glands of transgenic mice
    B Liu
    Vollum Institute for Advanced Biomedical Research, Oregon Health Sciences University, Portland 97201
    Mol Cell Biol 12:3978-90. 1992
    The proopiomelanocortin (POMC) gene is highly expressed in adult mouse pituitary anterior lobe corticotrophs and intermediate lobe melanotrophs...
  90. ncbi Selective reward deficit in mice lacking beta-endorphin and enkephalin
    Michael D Hayward
    The Vollum Institute, Oregon Health and Science University, Portland, Oregon 97201, USA
    J Neurosci 22:8251-8. 2002
    ..Because the attenuation of operant responding was observed only during a nondeprived motivational state, the hedonics of feeding are likely altered rather than energy homeostasis...
  91. pmc Essential role of mu opioid receptor in the regulation of delta opioid receptor-mediated antihyperalgesia
    L Gendron
    Department of Pharmacology, Health Sciences Building, University of Washington, Seattle, WA 98195 7280, USA
    Neuroscience 150:807-17. 2007
    ..We therefore conclude that DOR-mediated antihyperalgesia is dependent on MOR expression but that activation of MOR by endogenous opioids is probably not required...
  92. ncbi Coordinated regression of adrenocortical endocrine and endothelial compartments under adrenocorticotropin deprivation
    Michelle Keramidas
    Department of Cellular Responses and Dynamics, Commisariat à l Energie Atomique, Institut National de la Sante et de la Recherche Medicale, Grenoble, France
    Endocr Res 30:543-9. 2004
    ..The pituitary hormone ACTH controls the coordinated development of the vasculature and the endocrine tissue mass...
  93. ncbi Male-to-female sex reversal in mice lacking fibroblast growth factor 9
    J S Colvin
    Department of Molecular Biology and, Pharmacology, Washington University Medical School, Campus Box 8103, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Cell 104:875-89. 2001
    ..While Sry is found only in some mammals, Fgfs are highly conserved. Thus, Fgfs may function in sex determination and reproductive system development in many species...
  94. ncbi Dosage requirement of Pitx2 for development of multiple organs
    P J Gage
    Departments of Human Genetics and Neuroscience Program, University of Michigan Medical School, Ann Arbor, MI 48109 0638, USA
    Development 126:4643-51. 1999
    ..This allelic series establishes that Pitx2 is required for the development of mulitple organs in a dosage-sensitive manner...
  95. ncbi Expression of hypothalamic peptides in mice lacking neuronal nitric oxide synthase: reduced beta-END immunoreactivity in the arcuate nucleus
    H G Bernstein
    Department of Psychiatry, University of Magdeburg, Germany
    Neuroendocrinology 68:403-11. 1998
    ..the cellular expression of CRH, neurophysin (the carrier protein of vasopressin/oxytocin) and pro-opiomelanocortin (POMC), as well as of the POMC-derived peptides beta-endorphin (beta-END), alpha-melanocyte-stimulating hormone (alpha-..
  96. doi PDK1 deficiency in POMC-expressing cells reveals FOXO1-dependent and -independent pathways in control of energy homeostasis and stress response
    Bengt F Belgardt
    Institute for Genetics, Department of Mouse Genetics and Metabolism, Center for Molecular Medicine Cologne CMMC, University of Cologne, D 50674 Cologne, Germany
    Cell Metab 7:291-301. 2008
    ..To delineate the importance of pathways downstream of PI3K specifically in pro-opiomelanocortin (POMC) cell regulation, we have generated mice with selective inactivation of 3-phosphoinositide-dependent protein kinase ..
  97. ncbi ANF(1-28) is a potent suppressor of pro-opiomelanocortin (POMC) mRNA but a weak inhibitor of beta EP-LI release from AtT-20 cells
    T T Tan
    Cell Biology Unit, Mental Health Research Institute of Victoria, Royal Park Hospital, Parkville, Australia
    J Endocrinol 143:R1-4. 1994
    ..Furthermore, the cellular contents and secretion of (beta endorphin-like immunoreactivity) beta EP-LI from these cultures were also examined...
  98. ncbi Ethanol oral self-administration is increased in mutant mice with decreased beta-endorphin expression
    J E Grisel
    Department of Psychology, Furman University, Greenville, SC 29613
    Brain Res 835:62-7. 1999
    ..In this study, we used the beta-endorphin deficient mutant mouse line C57BL/6-Pomc1(tm1Low) to investigate the possible role of a specific opioid peptide on EtOH consumption...
  99. ncbi Pitx2 regulates lung asymmetry, cardiac positioning and pituitary and tooth morphogenesis
    C R Lin
    Howard Hughes Medical Institute, Department and School of Medicine, University of California, San Diego, La Jolla 92093, USA
    Nature 401:279-82. 1999
    ..Thus, Pitx2 is a transcription factor that encodes 'leftness' of the lung...
  100. pmc Hes1 is required for pituitary growth and melanotrope specification
    Lori T Raetzman
    University of Michigan, Ann Arbor 48109 0618, USA
    Dev Biol 304:455-66. 2007
    ..These results demonstrate that Notch signaling plays multiple roles in pituitary development, influencing precursor number, organ size, cell differentiation and ultimately cell fate...
  101. pmc Development of neuroendocrine lineages requires the bHLH-PAS transcription factor SIM1
    J L Michaud
    Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21210 USA
    Genes Dev 12:3264-75. 1998
    ..Our results strongly indicate that SIM1 functions upstream to maintain Brn2 expression, which in turn directs the terminal differentiation of specific neuroendocrine lineages within the PVN/SON...

Research Grants31

  1. Hypothalamic PI3K signaling in regulation of energy balance & glucose homeostasis
    Allison W Xu; Fiscal Year: 2010
    ..We will also evaluate the function of PI3K and Jak-Stat3 signaling in Pomc and Agrp neurons, two key leptin and insulin target neurons in the hypothalamus...
  2. Notch signaling regulates pituitary gland organogenesis
    Lori Raetzman; Fiscal Year: 2009
    ..They may also reveal genetic causes of congenital pituitary hormone deficiency and pituitary tumorigenesis and offer novel insight into the function of Notch signaling in endocrine cell differentiation. ..
  3. Melanocortin-4 Receptor Traffic and Signaling
    Giulia Baldini; Fiscal Year: 2010
    ..In conclusion, we anticipate that this project will help understand the cell biology of MC4R and that this will be important to find new therapeutic targets to prevent or reverse obesity. ..
  4. Hypothalamic circuits regulating energy balance and obesity: synaptic physiology
    SHANE THERESE HENTGES; Fiscal Year: 2010
    ..Proopiomelanocortin (POMC) neurons in the hypothalamic arcuate nucleus release multiple neuropeptides that are necessary for the maintenance ..
  5. Compensatory regulation of energy balance by neurogenesis in adult hypothalamus
    Allison W Xu; Fiscal Year: 2010
    ..It will provide novel insight into therapeutic potential of neural stem cells in treatment of hypothalamic neurodegeneration that are associated with a variety of chronic diseases and brain injuries. ..
  6. Hypothalamic circuits regulating energy balance and obesity: synaptic physiology
    SHANE THERESE HENTGES; Fiscal Year: 2010
    ..Proopiomelanocortin (POMC) neurons in the hypothalamic arcuate nucleus release multiple neuropeptides that are necessary for the maintenance ..
  7. Neurogenesis as a compensatory mechanism to regulate energy balance
    ALLISON XU; Fiscal Year: 2007
    ..The identification of neuronal substrates critical for body weight regulation will lay the groundwork for future therapeutic interventions designed to target these specific neurons. ..
  8. Mechanisms of Hormonal Release by Endocrine Cells
    Giulia Baldini; Fiscal Year: 2006
    ..This study of hormone release will help elucidate possible defects underlying endocrine diseases such as Diabetes Mellitus and Cushing syndrome. ..
  9. CRH--ENDOCRINE/IMMUNE INTERACTIONS
    CATHERINE KARALIS; Fiscal Year: 2001
    ..The proposed studies will advance the understanding of the pathogenesis of inflammation and autoimmunity, and thus, may provide new insignts for more effective management of autoimmune diseases and endotoxemia. ..
  10. MECHANISMS OF HORMONE RELEASE BY ENDOCRINE CELLS
    Giulia Baldini; Fiscal Year: 2002
    ..AtT-20 cells, which secrete adrenocorticotropic hormone (ACTH) are a very well characterized cellular model for regulated secretion...
  11. Operant Responding in Opioid-Deficient Mice
    Malcolm Low; Fiscal Year: 2004
    ..abstract_text> ..
  12. Hypothalamic PI3K signaling in regulation of energy balance & glucose homeostasis
    Allison W Xu; Fiscal Year: 2010
    ..We will also evaluate the function of PI3K and Jak-Stat3 signaling in Pomc and Agrp neurons, two key leptin and insulin target neurons in the hypothalamus...