Gene Symbol: PLU 1
Description: lysine (K)-specific demethylase 5B
Alias: 2010009J12Rik, 2210016I17Rik, AW556288, D1Ertd202e, Jarid1b, PLU-1, PUT1, Plu1, RBBP2H1A, Rb-Bp2, mKIAA4034, lysine-specific demethylase 5B, histone demethylase JARID1B, jumonji, AT rich interactive domain 1B (Rbp2 like), jumonji/ARID domain-containing protein 1B
Species: mouse
Products:     PLU 1

Top Publications

  1. Madsen B, Spencer Dene B, Poulsom R, Hall D, Lu P, Scott K, et al. Characterisation and developmental expression of mouse Plu-1, a homologue of a human nuclear protein (PLU-1) which is specifically up-regulated in breast cancer. Mech Dev. 2002;119 Suppl 1:S239-46 pubmed
    ..Thus Plu-1 appears to play an important role in mouse embryonic development which may involve interaction with Pax9 and Bf-1. ..
  2. Catteau A, Rosewell I, Solomon E, Taylor Papadimitriou J. A short region of the promoter of the breast cancer associated PLU-1 gene can regulate transcription in vitro and in vivo. Int J Oncol. 2004;25:5-16 pubmed
    ..This suggests that tissue specific controlling elements are found within the short fragment and are functional in the embryonic environment. ..
  3. Seward D, Cubberley G, Kim S, Schonewald M, Zhang L, Tripet B, et al. Demethylation of trimethylated histone H3 Lys4 in vivo by JARID1 JmjC proteins. Nat Struct Mol Biol. 2007;14:240-2 pubmed
    ..Ectopic overexpression of mouse Jarid1B, a Yjr119Cp homolog, greatly diminished H3-K4me3 and H3-K4me2 in HeLa cells, suggesting these proteins function ..
  4. Iwase S, Lan F, Bayliss P, de la Torre Ubieta L, Huarte M, Qi H, et al. The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases. Cell. 2007;128:1077-88 pubmed
    ..Our findings thus identify a family of H3K4me3 demethylases and uncover a critical link between histone modifications and XLMR...
  5. Dey B, Stalker L, Schnerch A, Bhatia M, Taylor Papidimitriou J, Wynder C. The histone demethylase KDM5b/JARID1b plays a role in cell fate decisions by blocking terminal differentiation. Mol Cell Biol. 2008;28:5312-27 pubmed publisher
    ..These findings demonstrate a role for KDM5b in the choice between proliferation and differentiation during development. ..
  6. Catchpole S, Spencer Dene B, Hall D, Santangelo S, Rosewell I, Guenatri M, et al. PLU-1/JARID1B/KDM5B is required for embryonic survival and contributes to cell proliferation in the mammary gland and in ER+ breast cancer cells. Int J Oncol. 2011;38:1267-77 pubmed publisher
    ..To investigate the function of the Jarid1B protein we examined the effects of deletion of the gene in mice...
  7. Schmitz S, Albert M, Malatesta M, Morey L, Johansen J, Bak M, et al. Jarid1b targets genes regulating development and is involved in neural differentiation. EMBO J. 2011;30:4586-600 pubmed publisher
    ..Here, we show that the H3K4me2/3 histone demethylase Jarid1b (Kdm5b/Plu1) is dispensable for ESC self-renewal, but essential for ESC differentiation along the ..
  8. He R, Kidder B. H3K4 demethylase KDM5B regulates global dynamics of transcription elongation and alternative splicing in embryonic stem cells. Nucleic Acids Res. 2017;45:6427-6441 pubmed publisher
    ..Altogether, our data indicate an epigenetic role for KDM5B in regulating RNAPII elongation and alternative splicing, which may support the diverse mRNA repertoire in ES cells. ..
  9. Zhou Q, Obana E, Radomski K, Sukumar G, Wynder C, Dalgard C, et al. Inhibition of the histone demethylase Kdm5b promotes neurogenesis and derepresses Reln (reelin) in neural stem cells from the adult subventricular zone of mice. Mol Biol Cell. 2016;27:627-39 pubmed publisher
    ..We show that the histone demethylase enzyme Kdm5b (Jarid1b) negatively regulates neurogenesis from adult subventricular zone (SVZ) neural stem cells (NSCs) in culture...

More Information


  1. Stewart M, Albert M, Sroczynska P, Cruickshank V, Guo Y, Rossi D, et al. The histone demethylase Jarid1b is required for hematopoietic stem cell self-renewal in mice. Blood. 2015;125:2075-8 pubmed publisher
    b>Jarid1b/KDM5b is a histone demethylase that regulates self-renewal and differentiation in stem cells and cancer; however, its function in hematopoiesis is unclear...
  2. Li X, Liu L, Yang S, Song N, Zhou X, Gao J, et al. Histone demethylase KDM5B is a key regulator of genome stability. Proc Natl Acad Sci U S A. 2014;111:7096-101 pubmed publisher
  3. Fork C, Gu L, Hitzel J, Josipovic I, Hu J, SzeKa Wong M, et al. Epigenetic Regulation of Angiogenesis by JARID1B-Induced Repression of HOXA5. Arterioscler Thromb Vasc Biol. 2015;35:1645-52 pubmed publisher
    ..The histone 3 lysine 4 demethylase JARID1B was identified as a highly expressed enzyme at the mRNA and protein levels...
  4. Albert M, Schmitz S, Kooistra S, Malatesta M, Morales Torres C, Rekling J, et al. The histone demethylase Jarid1b ensures faithful mouse development by protecting developmental genes from aberrant H3K4me3. PLoS Genet. 2013;9:e1003461 pubmed publisher
    ..Here we show that deletion of the H3K4me2/3 histone demethylase Jarid1b (Kdm5b/Plu1) results in major neonatal lethality due to respiratory failure...
  5. Uslu V, Petretich M, Ruf S, Langenfeld K, Fonseca N, Marioni J, et al. Long-range enhancers regulating Myc expression are required for normal facial morphogenesis. Nat Genet. 2014;46:753-8 pubmed publisher
    ..This dual molecular etiology may account for the prominent influence of variants in the 8q24 region on human facial dysmorphologies. ..
  6. DiTacchio L, Le H, Vollmers C, Hatori M, Witcher M, Secombe J, et al. Histone lysine demethylase JARID1a activates CLOCK-BMAL1 and influences the circadian clock. Science. 2011;333:1881-5 pubmed publisher
    ..Drosophila lines with reduced expression of the Jarid1a homolog, lid, had lowered Per expression and similarly altered circadian rhythms. JARID1a thus has a nonredundant role in circadian oscillator function. ..
  7. Frank D, Mendelsohn C, Ciccone E, Svensson K, Ohlsson R, Tycko B. A novel pleckstrin homology-related gene family defined by Ipl/Tssc3, TDAG51, and Tih1: tissue-specific expression, chromosomal location, and parental imprinting. Mamm Genome. 1999;10:1150-9 pubmed
    ..The data also define a new subfamily of PH domain genes. ..
  8. Costello I, Nowotschin S, Sun X, Mould A, Hadjantonakis A, Bikoff E, et al. Lhx1 functions together with Otx2, Foxa2, and Ldb1 to govern anterior mesendoderm, node, and midline development. Genes Dev. 2015;29:2108-22 pubmed publisher
    ..These partnerships cooperatively regulate development of the anterior mesendoderm, node, and midline cell populations responsible for establishment of the left-right body axis and head formation. ..
  9. Shao G, Chen J, Zhang L, Huang P, Lu H, Jin J, et al. Dynamic patterns of histone H3 lysine 4 methyltransferases and demethylases during mouse preimplantation development. In Vitro Cell Dev Biol Anim. 2014;50:603-13 pubmed publisher
    ..H3K4me3 was correlated to the expression of its methyltransferase (KMT2B) and demethylase (KDM5A). Thus, these enzymes may function for the EGA and the first lineage segregation in preimplantation mouse embryos. ..
  10. Xie L, Pelz C, Wang W, Bashar A, Varlamova O, Shadle S, et al. KDM5B regulates embryonic stem cell self-renewal and represses cryptic intragenic transcription. EMBO J. 2011;30:1473-84 pubmed publisher
    ..We propose that KDM5B activates self-renewal-associated gene expression by repressing cryptic initiation and maintaining an H3K4me3 gradient important for productive transcriptional elongation. ..
  11. Cellot S, Hope K, Chagraoui J, Sauvageau M, Deneault E, Macrae T, et al. RNAi screen identifies Jarid1b as a major regulator of mouse HSC activity. Blood. 2013;122:1545-55 pubmed publisher
    ..stem cell (HSC) behavior, we performed an in vivo RNAi-based functional screen and demonstrated that Jarid1b and Jhdm1f play opposing roles in regulation of HSC activity...
  12. Ma P, Pan H, Montgomery R, Olson E, Schultz R. Compensatory functions of histone deacetylase 1 (HDAC1) and HDAC2 regulate transcription and apoptosis during mouse oocyte development. Proc Natl Acad Sci U S A. 2012;109:E481-9 pubmed publisher
    ..Taken together, these results suggest seminal roles of acetylation of histone and nonhistone proteins in oocyte development. ..
  13. Rojas A, Aguilar R, Henriquez B, Lian J, Stein J, Stein G, et al. Epigenetic Control of the Bone-master Runx2 Gene during Osteoblast-lineage Commitment by the Histone Demethylase JARID1B/KDM5B. J Biol Chem. 2015;290:28329-42 pubmed publisher
    ..and Polycomb group complexes together with histone arginine methylases like PRMT5 and lysine demethylases like JARID1B/KDM5B...
  14. Nijwening J, Geutjes E, Bernards R, Beijersbergen R. The histone demethylase Jarid1b (Kdm5b) is a novel component of the Rb pathway and associates with E2f-target genes in MEFs during senescence. PLoS ONE. 2011;6:e25235 pubmed publisher
    ..We identified the H3K4-demethylase Jarid1b as novel component of the Rb pathway in this screening model...
  15. Pospisil V, Vargova K, Kokavec J, Rybarova J, Savvulidi F, Jonasova A, et al. Epigenetic silencing of the oncogenic miR-17-92 cluster during PU.1-directed macrophage differentiation. EMBO J. 2011;30:4450-64 pubmed publisher
    ..the secondary determinant Egr2 which, in turn, directly represses miR-17-92 expression by recruiting histone demethylase Jarid1b leading to histone H3 lysine K4 demethylation within the CpG island at the miR-17-92 promoter...
  16. Kidder B, Hu G, Yu Z, Liu C, Zhao K. Extended self-renewal and accelerated reprogramming in the absence of Kdm5b. Mol Cell Biol. 2013;33:4793-810 pubmed publisher
    ..These findings provide functional insight into the role for KDM5B in regulating ES cell differentiation and as a barrier to the reprogramming process. ..
  17. Zou M, Cao J, Liu Z, Huh S, Polyak K, Yan Q. Histone demethylase jumonji AT-rich interactive domain 1B (JARID1B) controls mammary gland development by regulating key developmental and lineage specification genes. J Biol Chem. 2014;289:17620-33 pubmed publisher
    The JmjC domain-containing H3K4 histone demethylase jumonji AT-rich interactive domain 1B (JARID1B) (also known as KDM5B and PLU1) is overexpressed in breast cancer and is a potential target for breast cancer treatment...
  18. Ptaschinski C, Mukherjee S, Moore M, Albert M, Helin K, Kunkel S, et al. RSV-Induced H3K4 Demethylase KDM5B Leads to Regulation of Dendritic Cell-Derived Innate Cytokines and Exacerbates Pathogenesis In Vivo. PLoS Pathog. 2015;11:e1004978 pubmed publisher
    ..RSV-infected bone marrow-derived DCs (BMDCs) upregulated expression of Kdm5b/Jarid1b H3K4 demethylase...
  19. Yoshida M, Ishimura A, Terashima M, Enkhbaatar Z, Nozaki N, Satou K, et al. PLU1 histone demethylase decreases the expression of KAT5 and enhances the invasive activity of the cells. Biochem J. 2011;437:555-64 pubmed publisher
    b>PLU1 is a candidate oncogene that encodes H3K4 (Lys(4) of histone H3) demethylase...
  20. Dahl J, Jung I, Aanes H, Greggains G, Manaf A, Lerdrup M, et al. Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition. Nature. 2016;537:548-552 pubmed publisher
    ..Our results provide insight into the onset of the developmental program in mouse embryos and demonstrate a role for broad H3K4me3 domains in MZT. ..
  21. Frankenberg S, Smith L, Greenfield A, Zernicka Goetz M. Novel gene expression patterns along the proximo-distal axis of the mouse embryo before gastrulation. BMC Dev Biol. 2007;7:8 pubmed
    ..5. At E5.5, prospective anterior markers are expressed at the distal tip of the embryo, whereas prospective posterior markers are expressed more proximally, close to the boundary with the extraembryonic region...