Gene Symbol: Plod2
Description: procollagen lysine, 2-oxoglutarate 5-dioxygenase 2
Alias: D530025C14Rik, LH2, Plod-2, procollagen-lysine,2-oxoglutarate 5-dioxygenase 2, lysyl hydroxylase 2
Species: mouse
Products:     Plod2

Top Publications

  1. Scheurer S, Rybak J, Rösli C, Neri D, Elia G. Modulation of gene expression by hypoxia in human umbilical cord vein endothelial cells: A transcriptomic and proteomic study. Proteomics. 2004;4:1737-60 pubmed
    ..g., CXCR4, claudin 3, CD24, tetranectin, Del-1, procollagen lysyl hydroxylase 1 and 2) which are transcriptionally upregulated in hypoxic conditions. ..
  2. Yeowell H, Walker L, Mauger D, Seth P, Garcia Blanco M. TIA nuclear proteins regulate the alternate splicing of lysyl hydroxylase 2. J Invest Dermatol. 2009;129:1402-11 pubmed publisher
    ..These cross-links are derived by the action of the alternatively spliced long form of lysyl hydroxylase 2 (LH2), a collagen telopeptide LH...
  3. Tao G, Levay A, Peacock J, Huk D, Both S, Purcell N, et al. Collagen XIV is important for growth and structural integrity of the myocardium. J Mol Cell Cardiol. 2012;53:626-38 pubmed publisher
  4. Hjalt T, Amendt B, Murray J. PITX2 regulates procollagen lysyl hydroxylase (PLOD) gene expression: implications for the pathology of Rieger syndrome. J Cell Biol. 2001;152:545-52 pubmed
    ..Mutations and rearrangements in PLOD-1 are known to be prevalent in patients with Ehlers-Danlos syndrome, kyphoscoliosis type (type VI [EDVI]). Several of the same organ systems are involved in Rieger syndrome and EDVI. ..
  5. Ruotsalainen H, Vanhatupa S, Tampio M, Sipilä L, Valtavaara M, Myllyla R. Complete genomic structure of mouse lysyl hydroxylase 2 and lysyl hydroxylase 3/collagen glucosyltransferase. Matrix Biol. 2001;20:137-46 pubmed
    ..J. Biol. Chem. 275 (2000) 36158-36163]. We report here the characterization of mouse LH2 (Plod2) and LH3/glucosyltransferase (Plod3) genes...
  6. Pornprasertsuk S, Duarte W, Mochida Y, Yamauchi M. Overexpression of lysyl hydroxylase-2b leads to defective collagen fibrillogenesis and matrix mineralization. J Bone Miner Res. 2005;20:81-7 pubmed
    ..These results indicate a critical role of LH2b catalyzed post-translational modification of collagen (i.e., telopeptidyl lysine hydroxylation and subsequent cross-linking) in collagen matrix formation and mineralization in bone. ..
  7. Chen Y, Guo H, Terajima M, Banerjee P, Liu X, Yu J, et al. Lysyl Hydroxylase 2 Is Secreted by Tumor Cells and Can Modify Collagen in the Extracellular Space. J Biol Chem. 2016;291:25799-25808 pubmed
    b>Lysyl hydroxylase 2 (LH2) catalyzes the hydroxylation of lysine residues in the telopeptides of fibrillar collagens, which leads to the formation of stable collagen cross-links...
  8. Ruotsalainen H, Sipilä L, Kerkela E, Pospiech H, Myllyla R. Characterization of cDNAs for mouse lysyl hydroxylase 1, 2 and 3, their phylogenetic analysis and tissue-specific expression in the mouse. Matrix Biol. 1999;18:325-9 pubmed
    We report on the isolation and characterization of cDNA clones for mouse lysyl hydroxylases 1, 2 and 3 (LH1, LH2, LH3)...
  9. Sipilä L, Szatanik M, Vainionpää H, Ruotsalainen H, Myllyla R, Guenet J. The genes encoding mouse lysyl hydroxylase isoforms map to chromosomes 4,5, and 9. Mamm Genome. 2000;11:1132-4 pubmed

More Information


  1. Lu X, Borchers A, Jolicoeur C, Rayburn H, Baker J, Tessier Lavigne M. PTK7/CCK-4 is a novel regulator of planar cell polarity in vertebrates. Nature. 2004;430:93-8 pubmed
    ..These results identify PTK7 as a novel regulator of PCP in vertebrates. ..
  2. Ruotsalainen H, Sipilä L, Vapola M, Sormunen R, Salo A, Uitto L, et al. Glycosylation catalyzed by lysyl hydroxylase 3 is essential for basement membranes. J Cell Sci. 2006;119:625-35 pubmed
    ..Together our results demonstrate for the first time the importance of hydroxylysine-linked glycosylation for collagens. ..
  3. Salo A, Sipilä L, Sormunen R, Ruotsalainen H, Vainio S, Myllyla R. The lysyl hydroxylase isoforms are widely expressed during mouse embryogenesis, but obtain tissue- and cell-specific patterns in the adult. Matrix Biol. 2006;25:475-83 pubmed
    Lysyl hydroxylase catalyzes the hydroxylation of lysine residues in collagenous sequences. Three isoforms (LH1, LH2 and LH3) of lysyl hydroxylase have been characterized, and LH2 is present as two alternatively spliced forms...
  4. Wang C, Risteli M, Heikkinen J, Hussa A, Uitto L, Myllyla R. Identification of amino acids important for the catalytic activity of the collagen glucosyltransferase associated with the multifunctional lysyl hydroxylase 3 (LH3). J Biol Chem. 2002;277:18568-73 pubmed
    ..These amino acids were conserved in C. elegans LH and mammalian LH3, but not in LH1 or LH2, which lack GGT activity...
  5. Pornprasertsuk S, Duarte W, Mochida Y, Yamauchi M. Lysyl hydroxylase-2b directs collagen cross-linking pathways in MC3T3-E1 cells. J Bone Miner Res. 2004;19:1349-55 pubmed
    ..Recently, we proposed that LH2 might modulate collagen cross-linking pattern through its action on Lys residues located in the telopeptide domains ..
  6. Rautavuoma K, Takaluoma K, Sormunen R, Myllyharju J, Kivirikko K, Soininen R. Premature aggregation of type IV collagen and early lethality in lysyl hydroxylase 3 null mice. Proc Natl Acad Sci U S A. 2004;101:14120-5 pubmed
    ..We propose that the premature aggregation of collagen IV is due to the absence of the hydroxylysine-linked carbohydrates, which thus play an essential role in its supramolecular assembly. ..
  7. Remst D, Blaney Davidson E, Vitters E, Blom A, Stoop R, Snabel J, et al. Osteoarthritis-related fibrosis is associated with both elevated pyridinoline cross-link formation and lysyl hydroxylase 2b expression. Osteoarthritis Cartilage. 2013;21:157-64 pubmed publisher
    ..Sections of murine knee joints injected with Ad-TGF-? or Ad-CTGF or from experimental OA were stained for lysyl hydroxylase 2 (LH2)...