Plk1

Summary

Gene Symbol: Plk1
Description: polo like kinase 1
Alias: Plk, STPK13, serine/threonine-protein kinase PLK1, PLK-1, serine/threonine-protein kinase 13
Species: mouse
Products:     Plk1

Top Publications

  1. Liu X, Lei M, Erikson R. Normal cells, but not cancer cells, survive severe Plk1 depletion. Mol Cell Biol. 2006;26:2093-108 pubmed
    We previously reported the phenotype of depletion of polo-like kinase 1 (Plk1) using RNA interference (RNAi) and showed that p53 is stabilized in Plk1-depleted cancer cells...
  2. Xiong B, Sun S, Lin S, Li M, Xu B, Ouyang Y, et al. Involvement of Polo-like kinase 1 in MEK1/2-regulated spindle formation during mouse oocyte meiosis. Cell Cycle. 2008;7:1804-9 pubmed
    ..In the present study, we found that Plk1 colocalized with p-MEK1/2 at various meiotic stages after GVBD when microtubule began to organize...
  3. Tong C, Fan H, Lian L, Li S, Chen D, Schatten H, et al. Polo-like kinase-1 is a pivotal regulator of microtubule assembly during mouse oocyte meiotic maturation, fertilization, and early embryonic mitosis. Biol Reprod. 2002;67:546-54 pubmed
    ..In this experiment, the changes in Plk1 expression were detected in mouse oocytes through Western blotting...
  4. Ito J, Yoon S, Lee B, Vanderheyden V, Vermassen E, Wojcikiewicz R, et al. Inositol 1,4,5-trisphosphate receptor 1, a widespread Ca2+ channel, is a novel substrate of polo-like kinase 1 in eggs. Dev Biol. 2008;320:402-13 pubmed publisher
    ..Here, we show that IP(3)R1 is a novel target for Polo-like kinase1 (Plk1), a conserved M-phase kinase, which phosphorylates it at an MPM-2 epitope...
  5. Lu L, Wood J, Minter Dykhouse K, Ye L, Saunders T, Yu X, et al. Polo-like kinase 1 is essential for early embryonic development and tumor suppression. Mol Cell Biol. 2008;28:6870-6 pubmed publisher
    ..Previous reports have shown that Plk1 is critical for all stages of mitosis and may play a role in DNA replication during S phase...
  6. Wianny F, Tavares A, Evans M, Glover D, Zernicka Goetz M. Mouse polo-like kinase 1 associates with the acentriolar spindle poles, meiotic chromosomes and spindle midzone during oocyte maturation. Chromosoma. 1998;107:430-9 pubmed
    We have examined the dynamics of the localisation of the polo-like kinase 1 (Plk1) during maturation of the mouse oocyte...
  7. Shirakawa J, Fernandez M, Takatani T, El Ouaamari A, Jungtrakoon P, Okawa E, et al. Insulin Signaling Regulates the FoxM1/PLK1/CENP-A Pathway to Promote Adaptive Pancreatic β Cell Proliferation. Cell Metab. 2017;25:868-882.e5 pubmed publisher
    ..insulin signaling promotes DNA-binding activity of FoxM1 to regulate expression of CENP-A and polo-like kinase-1 (PLK1) by modulating cyclin-dependent kinase-1/2...
  8. Wang H, Choe M, Lee I, Namgoong S, Kim J, Kim N, et al. CIP2A acts as a scaffold for CEP192-mediated microtubule organizing center assembly by recruiting Plk1 and aurora A during meiotic maturation. Development. 2017;144:3829-3839 pubmed publisher
    ..Aurora A and Plk1 are required for these events, but the underlying mechanisms remain largely unknown...
  9. Rios A, Fu N, Jamieson P, Pal B, Whitehead L, Nicholas K, et al. Essential role for a novel population of binucleated mammary epithelial cells in lactation. Nat Commun. 2016;7:11400 pubmed publisher

More Information

Publications85

  1. de Carcer G, Wachowicz P, Martínez Martínez S, Oller J, Méndez Barbero N, Escobar B, et al. Plk1 regulates contraction of postmitotic smooth muscle cells and is required for vascular homeostasis. Nat Med. 2017;23:964-974 pubmed publisher
    Polo-like kinase 1 (PLK1), an essential regulator of cell division, is currently undergoing clinical evaluation as a target for cancer therapy. We report an unexpected function of Plk1 in sustaining cardiovascular homeostasis...
  2. Lake R, Jelinek W. Cell cycle- and terminal differentiation-associated regulation of the mouse mRNA encoding a conserved mitotic protein kinase. Mol Cell Biol. 1993;13:7793-801 pubmed
    We determined the nucleotide sequence of a mouse and a human cDNA, which we designate STPK13, that encodes an apparent protein kinase related to that encoded by the Drosophila melanogaster polo gene and the Saccharomyces cerevisiae CDC5 ..
  3. Bengoechea Alonso M, Ericsson J. The phosphorylation-dependent regulation of nuclear SREBP1 during mitosis links lipid metabolism and cell growth. Cell Cycle. 2016;15:2753-65 pubmed publisher
    ..The phosphorylation of this residue creates a docking site for a separate mitotic kinase, Plk1. Plk1 interacts with nuclear SREBP1 in mitotic cells and phosphorylates a number of residues in the C-terminal ..
  4. Liu X, Song B, Elzey B, Ratliff T, Konieczny S, Cheng L, et al. Polo-like kinase 1 facilitates loss of Pten tumor suppressor-induced prostate cancer formation. J Biol Chem. 2011;286:35795-800 pubmed publisher
    ..Further, depletion of Pten results in elevated expression of Polo-like kinase 1 (Plk1), a critical regulator of the cell cycle...
  5. Yeh T, Kowalska A, Scipioni B, Cheong F, Zheng M, Derewenda U, et al. Dynactin helps target Polo-like kinase 1 to kinetochores via its left-handed beta-helical p27 subunit. EMBO J. 2013;32:1023-35 pubmed publisher
    ..kinase 1 (Cdk1) at a single site, p27 Thr186, to generate an anchoring site for polo-like kinase 1 (Plk1) at kinetochores...
  6. Takai N, Yoshimatsu J, Nishida Y, Narahara H, Miyakawa I, Hamanaka R. Expression of polo-like kinase (PLK) in the mouse placenta and ovary. Reprod Fertil Dev. 1999;11:31-5 pubmed
    The polo-like kinase (PLK) is a mammalian serine/threonine kinase involved in cell cycle regulation...
  7. Krupczak Hollis K, Wang X, Kalinichenko V, Gusarova G, Wang I, Dennewitz M, et al. The mouse Forkhead Box m1 transcription factor is essential for hepatoblast mitosis and development of intrahepatic bile ducts and vessels during liver morphogenesis. Dev Biol. 2004;276:74-88 pubmed
  8. Baran V, Solc P, Kovaríková V, Rehak P, Sutovsky P. Polo-like kinase 1 is essential for the first mitotic division in the mouse embryo. Mol Reprod Dev. 2013;80:522-34 pubmed publisher
    Polo-like kinase 1 (PLK1), a member of the serine/threonine protein kinases family, is involved in multiple steps of mitotic progression. It regulates centrosome maturation, mitotic spindle formation, and cytokinesis...
  9. Lange L, Hemmerich P, Spänkuch B. Survival of primary, but not of cancer cells after combined Plk1-HDAC inhibition. Oncotarget. 2015;6:25801-14 pubmed publisher
    ..Western blot and quantitative real time analyses revealed reduced Plk1 mRNA and protein in all cells...
  10. Lin H, Ting N, Qin J, Lee W. M phase-specific phosphorylation of BRCA2 by Polo-like kinase 1 correlates with the dissociation of the BRCA2-P/CAF complex. J Biol Chem. 2003;278:35979-87 pubmed
    ..identified two phosphopeptides that contain "phosphorylation consensus motifs" for Polo-like kinase 1 (Plk1)...
  11. Sakai D, Dixon J, Dixon M, Trainor P. Mammalian neurogenesis requires Treacle-Plk1 for precise control of spindle orientation, mitotic progression, and maintenance of neural progenitor cells. PLoS Genet. 2012;8:e1002566 pubmed publisher
    ..We determined that Treacle elicits its effect via a direct interaction with Polo-like kinase1 (Plk1), and furthermore we discovered novel in vivo roles for Plk1 in governing mitotic progression and spindle ..
  12. Sun S, Liu H, Sun Q. Survivin regulates Plk1 localization to kinetochore in mouse oocyte meiosis. Biochem Biophys Res Commun. 2012;421:797-800 pubmed publisher
    ..b>Plk1 (polo-like kinase 1) associates with the spindle poles and also distributes to the kinetochores and is shown to ..
  13. Jordan P, Karppinen J, Handel M. Polo-like kinase is required for synaptonemal complex disassembly and phosphorylation in mouse spermatocytes. J Cell Sci. 2012;125:5061-72 pubmed publisher
    ..All four PLKs are expressed during the first wave of spermatogenesis. Only PLK1 (not PLK2-4) localizes to the SC during the G2/MI transition...
  14. Li L, Sase A, Patil S, Sunyer B, Hoger H, Smalla K, et al. Distinct set of kinases induced after retrieval of spatial memory discriminate memory modulation processes in the mouse hippocampus. Hippocampus. 2013;23:672-83 pubmed publisher
    ..Together with its recently observed genetic association to autism-spectrum disorders our data suggest a role of this kinase in balancing preservation and flexibility of learned behavior. ..
  15. Zhang B, Wang G, Xu X, Yang S, Zhuang T, Wang G, et al. DAZ-interacting Protein 1 (Dzip1) Phosphorylation by Polo-like Kinase 1 (Plk1) Regulates the Centriolar Satellite Localization of the BBSome Protein during the Cell Cycle. J Biol Chem. 2017;292:1351-1360 pubmed publisher
    ..Phosphorylation of Dzip1 at Ser-210 by Plk1 (polo-like kinase 1) during the G2 phase promotes disassembly of this complex, resulting in removal of ..
  16. Yu A, Zhang Z, Bi Q, Sun B, Su W, Guan Y, et al. Regulation of cAMP on the first mitotic cell cycle of mouse embryos. Mol Reprod Dev. 2008;75:489-95 pubmed
    ..In the downstream of cAMP/PKA, there are some effectors such as polo-like kinase 1 (Plk1), Cdc25, Mos (mitogen-activated protein kinase kinase kinase), MEK (mitogen-activated protein kinase kinase), ..
  17. Yarm F. Plk phosphorylation regulates the microtubule-stabilizing protein TCTP. Mol Cell Biol. 2002;22:6209-21 pubmed
    ..and -stabilizing protein, the translationally controlled tumor protein (TCTP), was identified as a putative Plk-interacting clone by a two-hybrid screen...
  18. He Z, Wu J, Dang H, Lin H, Zheng H, Zhong D. Polo-like kinase 1 contributes to the tumorigenicity of BEL-7402 hepatoma cells via regulation of Survivin expression. Cancer Lett. 2011;303:92-8 pubmed publisher
    Polo-like kinase 1 (PLK1) is required for multiple stages of mitosis and has been found to be overexpressed in many human malignancies...
  19. Tay J, Richter J. Germ cell differentiation and synaptonemal complex formation are disrupted in CPEB knockout mice. Dev Cell. 2001;1:201-13 pubmed
    ..Synaptonemal complexes were not detected in these animals. CPEB therefore controls germ cell differentiation by regulating the formation of the synaptonemal complex. ..
  20. Guarguaglini G, Duncan P, Stierhof Y, Holmström T, Duensing S, Nigg E. The forkhead-associated domain protein Cep170 interacts with Polo-like kinase 1 and serves as a marker for mature centrioles. Mol Biol Cell. 2005;16:1095-107 pubmed
    ..Cep170 was identified in a yeast two-hybrid screen for interactors of Polo-like kinase 1 (Plk1). In human cells, Cep170 is constantly expressed throughout the cell cycle but phosphorylated during mitosis...
  21. Kushner E, Ferro L, Liu J, Durrant J, Rogers S, Dudley A, et al. Excess centrosomes disrupt endothelial cell migration via centrosome scattering. J Cell Biol. 2014;206:257-72 pubmed publisher
    ..tumor endothelial cells with supernumerary centrosomes had less centrosome-localized ?-tubulin, and Plk1 blockade prevented MT growth, whereas overexpression rescued centrosome ?-tubulin levels and centrosome dynamics...
  22. Castiel A, Danieli M, David A, Moshkovitz S, Aplan P, Kirsch I, et al. The Stil protein regulates centrosome integrity and mitosis through suppression of Chfr. J Cell Sci. 2011;124:532-9 pubmed publisher
    ..5 Stil(-/-) embryos, express high levels of the Chfr protein and reduced levels of the Chfr substrate Plk1. Exogenous expression of Stil, knockdown of Chfr or overexpression of Plk1 reverse the abnormal mitotic phenotypes ..
  23. Matsubara N, Yanagisawa M, Nishimune Y, Obinata M, Matsui Y. Murine polo like kinase 1 gene is expressed in meiotic testicular germ cells and oocytes. Mol Reprod Dev. 1995;41:407-15 pubmed
    ..of the entire coding regions shows that this clone, designated Plk1(polo like kinase 1), is identical with STPK13 previously cloned from murine erythro-leukemia cells...
  24. Chatterjee R, Chattopadhyay S, Law S. Deregulation of vital mitotic kinase-phosphatase signaling in hematopoietic stem/progenitor compartment leads to cellular catastrophe in experimental aplastic anemia. Mol Cell Biochem. 2016;422:121-134 pubmed
    ..role of some crucial mitotic and apoptotic regulators like Protein kinase-B (PKB), Gsk-3?, Cyclin-D1, PP2A, Cdc25c, Plk-1, Aurora kinase-A, Chk-1 regarding the hematopoietic catastrophe...
  25. Holt J, Pye V, Boon E, Stewart J, Garcia Higuera I, Moreno S, et al. The APC/C activator FZR1 is essential for meiotic prophase I in mice. Development. 2014;141:1354-65 pubmed publisher
  26. Wachowicz P, Fernández Miranda G, Marugán C, Escobar B, de Cárcer G. Genetic depletion of Polo-like kinase 1 leads to embryonic lethality due to mitotic aberrancies. Bioessays. 2016;38 Suppl 1:S96-S106 pubmed publisher
    Polo-like kinase 1 (PLK1) is a serine/threonine kinase that plays multiple and essential roles during the cell division cycle. Its inhibition in cultured cells leads to severe mitotic aberrancies and cell death...
  27. Pearson J, Godinho S, Tavares A, Glover D. Heterologous expression of mammalian Plk1 in Drosophila reveals divergence from Polo during late mitosis. Exp Cell Res. 2006;312:770-81 pubmed
    ..We assessed the ability of mouse Polo-like kinase 1 (Plk1) to perform the multiple mitotic functions of Polo kinase, by expressing a Plk1-GFP fusion in Drosophila...
  28. Choi B, Pagano M, Dai W. Plk1 protein phosphorylates phosphatase and tensin homolog (PTEN) and regulates its mitotic activity during the cell cycle. J Biol Chem. 2014;289:14066-74 pubmed publisher
    ..Pulldown analysis revealed that Plk1 physically interacted with PTEN...
  29. Vertii A, Ivshina M, Zimmerman W, Hehnly H, Kant S, Doxsey S. The Centrosome Undergoes Plk1-Independent Interphase Maturation during Inflammation and Mediates Cytokine Release. Dev Cell. 2016;37:377-386 pubmed publisher
    ..maturation occurs during interphase in an MLK-dependent manner, independent of the classic mitotic kinase, Plk1. Centrosome disruption by chemical prevention of centriole assembly or genetic ablation of pericentrin attenuated ..
  30. Huo L, Fan H, Zhong Z, Chen D, Schatten H, Sun Q. Ubiquitin-proteasome pathway modulates mouse oocyte meiotic maturation and fertilization via regulation of MAPK cascade and cyclin B1 degradation. Mech Dev. 2004;121:1275-87 pubmed
    ..metaphase I spindle assembly was prevented, and the distribution of ubiquitin, cyclin B1, and polo-like kinase 1 (Plk1) was also distorted...
  31. Brown M, Yui K, Smith J, LeBoeuf R, Weng W, Umeda P, et al. The murine macrophage apoB-48 receptor gene (Apob-48r): homology to the human receptor. J Lipid Res. 2002;43:1181-91 pubmed
  32. Hopitzan A, Himmelbauer H, Spevak W, Castanon M. The mouse Psma1 gene coding for the alpha-type C2 proteasome subunit: structural and functional analysis, mapping, and colocalization with Pde3b on mouse chromosome 7. Genomics. 2000;66:313-23 pubmed
    ..3 in a region syntenic to human chromosome 11p15. Our results extend the structural and functional analysis of genes encoding the 20S proteasome subunits and provide the basis for the study of their regulation. ..
  33. Raab M, Kappel S, Kramer A, Sanhaji M, Matthess Y, Kurunci Csacsko E, et al. Toxicity modelling of Plk1-targeted therapies in genetically engineered mice and cultured primary mammalian cells. Nat Commun. 2011;2:395 pubmed publisher
    ..Although polo-like kinase 1 (Plk1) inhibitors are attractive candidates for drug development, the role of Plk1 in primary cells remains widely ..
  34. Xu S, Ladak R, Swanson D, Soltyk A, Sun H, Ploder L, et al. PHR1 encodes an abundant, pleckstrin homology domain-containing integral membrane protein in the photoreceptor outer segments. J Biol Chem. 1999;274:35676-85 pubmed
    ..This activity and subcellular location suggests that PHR1 may function as a previously unrecognized modulator of the phototransduction pathway. ..
  35. Ferris D, Maloid S, Li C. Ubiquitination and proteasome mediated degradation of polo-like kinase. Biochem Biophys Res Commun. 1998;252:340-4 pubmed
    Polo-like kinase (Plk) is a cell cycle-regulated, cyclin-independent serine/threonine protein kinase...
  36. Treekitkarnmongkol W, Katayama H, Kai K, Sasai K, Jones J, Wang J, et al. Aurora kinase-A overexpression in mouse mammary epithelium induces mammary adenocarcinomas harboring genetic alterations shared with human breast cancer. Carcinogenesis. 2016;37:1180-1189 pubmed
    ..Aurora-A overexpression in the tumor tissues accompanied activation of Akt, elevation of Cyclin D1, Tpx2 and Plk1 along with downregulation of ER? and p53 proteins, albeit at varying levels...
  37. Baran V, Brzakova A, Rehák P, Kovarikova V, Solc P. PLK1 regulates spindle formation kinetics and APC/C activation in mouse zygote. Zygote. 2016;24:338-45 pubmed publisher
    Polo-like kinase 1 (PLK1) is involved in essential events of cell cycle including mitosis in which it participates in centrosomal microtubule nucleation, spindle bipolarity establishment and cytokinesis...
  38. Feitosa W, Hwang K, Morris P. Temporal and SUMO-specific SUMOylation contribute to the dynamics of Polo-like kinase 1 (PLK1) and spindle integrity during mouse oocyte meiosis. Dev Biol. 2018;434:278-291 pubmed publisher
    During mammalian meiosis, Polo-like kinase 1 (PLK1) is essential during cell cycle progression...
  39. Mondal G, Ohashi A, Yang L, Rowley M, Couch F. Tex14, a Plk1-regulated protein, is required for kinetochore-microtubule attachment and regulation of the spindle assembly checkpoint. Mol Cell. 2012;45:680-95 pubmed publisher
    ..that testis-expressed protein 14 (Tex14), which has been implicated in midbody function, is recruited to KTs by Plk1 in a Cdk1-dependent manner during early mitosis...
  40. Yagi M, Roth G. Megakaryocyte polyploidization is associated with decreased expression of polo-like kinase (PLK). J Thromb Haemost. 2006;4:2028-34 pubmed
    ..The gene encoding mouse polo-like kinase 1 (PLK-1) was introduced into MK by retroviral transduction, and its effects measured by flow cytometry...
  41. Zheng P, Dean J. Role of Filia, a maternal effect gene, in maintaining euploidy during cleavage-stage mouse embryogenesis. Proc Natl Acad Sci U S A. 2009;106:7473-8 pubmed publisher
    ..e., AURKA, PLK1, and gamma-tubulin) to the microtubule-organizing center via the RhoA signaling pathway...
  42. Mihalas A, Araki Y, Huganir R, Meffert M. Opposing action of nuclear factor ?B and Polo-like kinases determines a homeostatic end point for excitatory synaptic adaptation. J Neurosci. 2013;33:16490-501 pubmed publisher
    ..Chronic elevated activity, which induces Plk expression, also produces Plk-dependent activation of NF-?B...
  43. Ajduk A, Strauss B, Pines J, Zernicka Goetz M. Delayed APC/C activation extends the first mitosis of mouse embryos. Sci Rep. 2017;7:9682 pubmed publisher
    ..Our findings that the SAC prevents cyclin A2 degradation, whereas over-expressed Plk1 stimulates it, support our conclusion that the delay in cyclin A2 degradation is caused by low APC/C activity...
  44. Li J, Wang R, Gannon O, Rezey A, Jiang S, Gerlach B, et al. Polo-like Kinase 1 Regulates Vimentin Phosphorylation at Ser-56 and Contraction in Smooth Muscle. J Biol Chem. 2016;291:23693-23703 pubmed
    Polo-like kinase 1 (Plk1) is a serine/threonine-protein kinase that has been implicated in mitosis, cytokinesis, and smooth muscle cell proliferation. The role of Plk1 in smooth muscle contraction has not been investigated...
  45. Hwang G, Sun F, O Brien M, Eppig J, Handel M, Jordan P. SMC5/6 is required for the formation of segregation-competent bivalent chromosomes during meiosis I in mouse oocytes. Development. 2017;144:1648-1660 pubmed publisher
  46. Studach L, Rakotomalala L, Wang W, Hullinger R, Cairo S, Buendia M, et al. Polo-like kinase 1 inhibition suppresses hepatitis B virus X protein-induced transformation in an in vitro model of liver cancer progression. Hepatology. 2009;50:414-23 pubmed publisher
    ..One of these genes is the mitotic kinase Polo-like kinase 1 (Plk1). Oncogenic transformation is suppressed in the absence of pX expression, and significantly, by inhibition of Plk1...
  47. Lee K, Johmura Y, Yu L, Park J, Gao Y, Bang J, et al. Identification of a novel Wnt5a-CK1?-Dvl2-Plk1-mediated primary cilia disassembly pathway. EMBO J. 2012;31:3104-17 pubmed publisher
    ..Here, we report unexpected roles of Dishevelled 2 (Dvl2) and interphase polo-like kinase 1 (Plk1) in primary cilia disassembly...
  48. Ward A, Hudson J. p53-Dependent and cell specific epigenetic regulation of the polo-like kinases under oxidative stress. PLoS ONE. 2014;9:e87918 pubmed publisher
    ..The PLKs have been implicated in a variety of cancers, such as hepatocellular carcinoma (HCC), with PLK1 typically overexpressed and PLKs 2-5 often downregulated...
  49. Valianou M, Cox A, Pichette B, Hartley S, Paladhi U, Astrinidis A. Pharmacological inhibition of Polo-like kinase 1 (PLK1) by BI-2536 decreases the viability and survival of hamartin and tuberin deficient cells via induction of apoptosis and attenuation of autophagy. Cell Cycle. 2015;14:399-407 pubmed publisher
    ..Hamartin interacts with the centrosomal and mitotic kinase polo-like kinase 1 (PLK1)...
  50. Masuhara M, Nagao K, Nishikawa M, Sasaki M, Yoshimura A, Osawa M. Molecular cloning of murine STAP-1, the stem-cell-specific adaptor protein containing PH and SH2 domains. Biochem Biophys Res Commun. 2000;268:697-703 pubmed
    ..These suggest that STAP-1 functions as an adaptor molecule downstream of c-kit in hematopoietic stem cells. ..
  51. Shen W, Ahmad F, Hockman S, Ma J, Omi H, Raghavachari N, et al. Female infertility in PDE3A(-/-) mice: polo-like kinase 1 (Plk1) may be a target of protein kinase A (PKA) and involved in meiotic arrest of oocytes from PDE3A(-/-) mice. Cell Cycle. 2010;9:4720-34 pubmed
    ..G2/M-arrested PDE3A(-/-) murine oocytes, elevated PKA activity was associated with inactivation of Cdc2 and Plk1, and inhibition of phosphorylation of histone H3 (S10) and of dephosphorylation of Cdc25B (S323) and Cdc2 (Thr14/..
  52. Lundberg Y, Cabrera R, Greer K, Zhao J, Garg R, Finnell R. Mapping a chromosomal locus for valproic acid-induced exencephaly in mice. Mamm Genome. 2004;15:361-9 pubmed
    ..These results suggest a major chromosomal locus associated with the sensitivity to VPA-induced exencephaly in mice. ..
  53. Izumiyama T, Minoshima S, Yoshida T, Shimizu N. A novel big protein TPRBK possessing 25 units of TPR motif is essential for the progress of mitosis and cytokinesis. Gene. 2012;511:202-17 pubmed publisher
  54. Xiao D, Yue M, Su H, Ren P, Jiang J, Li F, et al. Polo-like Kinase-1 Regulates Myc Stabilization and Activates a Feedforward Circuit Promoting Tumor Cell Survival. Mol Cell. 2016;64:493-506 pubmed publisher
    ..Here, we identify a molecular mechanism responsible for reciprocal activation between Polo-like kinase-1 (PLK1) and N-Myc...
  55. Kim I, Ramakrishna S, Gusarova G, Yoder H, Costa R, Kalinichenko V. The forkhead box m1 transcription factor is essential for embryonic development of pulmonary vasculature. J Biol Chem. 2005;280:22278-86 pubmed
    ..In summary, development of mouse lungs depends on the Foxm1 transcription factor, which regulates expression of genes essential for mesenchyme proliferation, extracellular matrix remodeling, and vasculogenesis. ..
  56. Solc P, Kitajima T, Yoshida S, Brzakova A, Kaido M, Baran V, et al. Multiple requirements of PLK1 during mouse oocyte maturation. PLoS ONE. 2015;10:e0116783 pubmed publisher
    Polo-like kinase 1 (PLK1) orchestrates multiple events of cell division...
  57. Clay F, McEwen S, Bertoncello I, Wilks A, Dunn A. Identification and cloning of a protein kinase-encoding mouse gene, Plk, related to the polo gene of Drosophila. Proc Natl Acad Sci U S A. 1993;90:4882-6 pubmed
    ..is closely related to the enzyme encoded by the Drosophila melanogaster mutant polo and that we have designated Plk (polo-like kinase)...
  58. Anger M, Kues W, Klima J, Mielenz M, Kubelka M, Motlik J, et al. Cell cycle dependent expression of Plk1 in synchronized porcine fetal fibroblasts. Mol Reprod Dev. 2003;65:245-53 pubmed
    ..We have cloned cDNA fragments of the porcine homologues of Plk1, Plk2, and Plk3 employing fetal fibroblasts as source...
  59. Ramakrishna S, Kim I, Petrovic V, Malin D, Wang I, Kalin T, et al. Myocardium defects and ventricular hypoplasia in mice homozygous null for the Forkhead Box M1 transcription factor. Dev Dyn. 2007;236:1000-13 pubmed
    ..Foxm1 regulates expression of genes essential for the proliferation of cardiomyocytes during heart development. ..
  60. Glowacki G, Braren R, Cetkovic Cvrlje M, Leiter E, Haag F, Koch Nolte F. Structure, chromosomal localization, and expression of the gene for mouse ecto-mono(ADP-ribosyl)transferase ART5. Gene. 2001;275:267-77 pubmed
    ..The secreted epitope-tagged ART5 protein resembled rat ART2 in exhibiting potent NAD-glycohydrolase activity. This study provides important experimental tools to further elucidate the function of ART5. ..
  61. Xiong F, Lin Y, Han Z, Shi G, Tian L, Wu X, et al. Plk1-mediated phosphorylation of UAP56 regulates the stability of UAP56. Mol Biol Rep. 2012;39:1935-42 pubmed publisher
    Polo-like kinase 1 (Plk1) is a conserved serine/threonine protein kinase that plays pivotal roles during the cell cycle and cell proliferation...
  62. Bräuninger A, Strebhardt K, Rübsamen Waigmann H. Identification and functional characterization of the human and murine polo-like kinase (Plk) promoter. Oncogene. 1995;11:1793-800 pubmed
    The Plk gene encodes a serine/theronine kinase which is located in the nucleus. Northern blot analysis linked Plk expression to the proliferative activity of cells and tissues...
  63. Wang X, Harding H, Zhang Y, Jolicoeur E, Kuroda M, Ron D. Cloning of mammalian Ire1 reveals diversity in the ER stress responses. EMBO J. 1998;17:5708-17 pubmed
    ..These results indicate that a single upstream component, Ire1, plays a role in multiple facets of the ER stress-response in mammalian cells. ..
  64. Arai T, Haze K, Iimura Morita Y, Machida T, Iida M, Tanaka K, et al. Identification of beta-catenin as a novel substrate of Polo-like kinase 1. Cell Cycle. 2008;7:3556-63 pubmed
    Polo-like kinase 1 (Plk1) is a serine/threonine kinase that plays an important role in M phase progression by regulating various downstream substrates via phosphorylation...
  65. Lee K, Yuan Y, Kuriyama R, Erikson R. Plk is an M-phase-specific protein kinase and interacts with a kinesin-like protein, CHO1/MKLP-1. Mol Cell Biol. 1995;15:7143-51 pubmed
    PLK (STPK13) encodes a murine protein kinase closely related to those encoded by the Drosophila melanogaster polo gene and the Saccharomyces cerevisiae CDC5 gene, which are required for normal mitotic and meiotic divisions...
  66. Ruiz J, Conlon F, Robertson E. Identification of novel protein kinases expressed in the myocardium of the developing mouse heart. Mech Dev. 1994;48:153-64 pubmed
    ..75-8.5 dpc developing heart. Subsequently, msk mRNA expression is rapidly downregulated. The patterns of Hek2 and msk expression suggest that these protein kinases may function during development of the primitive heart. ..
  67. Nelms K, O Neill T, Li S, Hubbard S, Gustafson T, Paul W. Alternative splicing, gene localization, and binding of SH2-B to the insulin receptor kinase domain. Mamm Genome. 1999;10:1160-7 pubmed
    ..Additionally, the chromosomal location of the SH2-B gene was determined to be the distal arm of mouse Chromosome (Chr) 7 in a region linked to obesity in mice. ..
  68. Du J, Cao Y, Wang Q, Zhang N, Liu X, Chen D, et al. Unique subcellular distribution of phosphorylated Plk1 (Ser137 and Thr210) in mouse oocytes during meiotic division and pPlk1(Ser137) involvement in spindle formation and REC8 cleavage. Cell Cycle. 2015;14:3566-79 pubmed publisher
    Polo-like kinase 1 (Plk1) is pivotal for proper mitotic progression, its targeting activity is regulated by precise subcellular positioning and phosphorylation...
  69. Kim S, Yoon S, Choi N, Hong K, Murugan R, Cho G, et al. In vivo tumor imaging using polo-box domain of polo-like kinase 1 targeted peptide. Biomaterials. 2012;33:6915-25 pubmed publisher
    Polo-like kinase 1 (Plk1) is a regulator of cell cycle progression during mitosis; it is overexpressed in many different tumors and has been implicated as a potential antimitotic target...
  70. Miyara F, Han Z, Gao S, Vassena R, Latham K. Non-equivalence of embryonic and somatic cell nuclei affecting spindle composition in clones. Dev Biol. 2006;289:206-17 pubmed
    ..These results reveal a striking control of SCC formation by the transplanted nucleus and provide the first identified molecular correlate of donor stage-dependent restriction in nuclear potency. ..
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