Genomes and Genes
Gene Symbol: Plg
Alias: AI649309, plasminogen, angiostatin, plasmin heavy chain A, plasmin light chain B
Publications119 found, 100 shown here
- Plasminogen deficiency causes severe thrombosis but is compatible with development and reproductionT H Bugge
Division of Basic Science Research, Children s Hospital Research Foundation, Cincinnati, Ohio 45229, USA
Genes Dev 9:794-807. 1995b>Plasminogen (Plg)-deficient mice were generated to define the physiological roles of this key fibrinolytic protein and its proteolytic derivatives, plasmin and angiostatin, in development, hemostasis, and reproduction...
- Impaired wound healing in mice with a disrupted plasminogen geneJ Romer
Finsen Laboratory, Rigshospitalet, Copenhagen, Denmark
Nat Med 2:287-92. 1996Activation of plasminogen (Plg) has been proposed to play a role in proteolytic degradation of extracellular matrices in tissue remodeling events, including wound healing...
- Persistent corneal haze after excimer laser photokeratectomy in plasminogen-deficient miceA F Drew
Children s Hospital Research Foundation, Cincinnati, Ohio, USA
Invest Ophthalmol Vis Sci 41:67-72. 2000..Fibrin deposition and resolution after excimer laser photokeratectomy were investigated in relation to corneal repair and restoration of clarity in mice with a genetic deficiency of plasminogen.
- In vivo plasminogen deficiency reduces fat accumulationJane Hoover-Plow
Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic Foundation, Ohio 44195, USA
Thromb Haemost 87:1011-9. 2002..and non-insulin dependent diabetes are associated with a decrease in fibrinolysis, which is mediated by the plasminogen system...
- A plasminogen-like protein selectively degrades stearoyl-CoA desaturase in liver microsomesF Scott Heinemann
Department of Pathology, Hoag Memorial Hospital Presbyterian, Newport Beach, California 92663, USA
J Biol Chem 278:42966-75. 2003..Here we show that the 90-kDa protein is a microsomal form of plasminogen (Pg) and that the purified SCD protease contains a spectrum of plasmin-like derivatives...
- Stromelysin-1 (MMP-3) is critical for intracranial bleeding after t-PA treatment of stroke in miceY Suzuki
Center for Molecular and Vascular Biology, KU Leuven, Leuven, Belgium
J Thromb Haemost 5:1732-9. 2007Tissue-type plasminogen activator (t-PA) is approved for treatment of ischemic stroke patients, but it may increase the risk of intracranial bleeding (ICB)...
- The low-density lipoprotein receptor-related protein 1 mediates tissue-type plasminogen activator-induced microglial activation in the ischemic brainChen Zhang
Department of Neurology and Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA 30322, USA
Am J Pathol 174:586-94. 2009..Tissue-type plasminogen activator (tPA) is a serine proteinase that is found in the intravascular space and the CNS...
- The pro- or antiangiogenic effect of plasminogen activator inhibitor 1 is dose dependentLaetitia Devy
Laboratory of Tumor and Developmental Biology, University of Liege, Tour de Pathologie B23, Sart Tilman, B 4000 Liege, Belgium
FASEB J 16:147-54. 2002b>Plasminogen activator inhibitor 1 (PAI-1) is believed to control proteolytic activity and cell migration during angiogenesis...
- Plasminogen activator inhibitor type-1 deficiency does not influence the outcome of murine pneumococcal pneumoniaAnita W Rijneveld
Academic Medical Center, University of Amsterdam, F4 222, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
Blood 102:934-9. 2003Urokinase-type plasminogen activator (uPA) and its receptor uPAR are components of the fibrinolytic system and are important for an adequate immune response to respiratory tract infection, in part through their role in the migration of ..
- Characterization of the cDNA coding for mouse plasminogen and localization of the gene to mouse chromosome 17S J Degen
Children s Hospital Research Foundation, University of Cincinnati, Ohio 45229
Genomics 8:49-61. 1990A full-length cDNA coding for mouse plasminogen has been isolated and characterized...
- Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinomaM S O'Reilly
Department of Surgery, Children s Hospital, Boston, Massachusetts
Cell 79:315-28. 1994..The activity copurifies with a 38 kDa plasminogen fragment that we have sequenced and named angiostatin. A corresponding fragment of human plasminogen has similar activity...
- Effects of disruption of the plasminogen gene on thrombosis, growth, and health in miceV A Ploplis
Center for Transgene Technology and Gene Therapy, Vlaams Interuniversitair Instituut voor Biotechnologie, KU Leuven, Belgium
Circulation 92:2585-93. 1995Circumstantial evidence suggests that the plasminogen/plasmin system plays a role in many biological processes, including hemostasis, cell migration, and development.
- Loss of fibrinogen rescues mice from the pleiotropic effects of plasminogen deficiencyT H Bugge
Division of Developmental Biology, Children s Hospital Research Foundation, Cincinnati, Ohio 45229, USA
Cell 87:709-19. 1996..b>Plasminogen (Plg) deficiency in mice results in high mortality, wasting, spontaneous gastrointestinal ulceration, rectal ..
- An extracellular proteolytic cascade promotes neuronal degeneration in the mouse hippocampusS E Tsirka
Department of Pharmacology, University Medical Center at Stony Brook, New York 11794 8651, USA
J Neurosci 17:543-52. 1997Mice lacking the serine protease tissue plasminogen activator (tPA) are resistant to excitotoxin-mediated hippocampal neuronal degeneration. We have used genetic and cellular analyses to study the role of tPA in neuronal cell death...
- Plasminogen deficiency differentially affects recruitment of inflammatory cell populations in miceV A Ploplis
Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Blood 91:2005-9. 1998It is widely held that the plasminogen (Plg) system plays a role in inflammation through plasmin-mediated directional cell migration...
- Reduced transplant arteriosclerosis in plasminogen-deficient miceL Moons
Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, B 3000 Leuven, Belgium
J Clin Invest 102:1788-97. 1998Recent gene targeting studies indicate that the plasminogen system is implicated in cell migration and matrix degradation during arterial neointima formation and atherosclerotic aneurysm formation...
- Role of plasminogen system components in focal cerebral ischemic infarction: a gene targeting and gene transfer study in miceN Nagai
Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, Center for Molecular and Vascular Biology, KU Leuven, Belgium
Circulation 99:2440-4. 1999The role of plasminogen system components in focal cerebral ischemic infarction (FCI) was studied in mice deficient in plasminogen (Plg-/-), in tissue or urokinase plasminogen activator (tPA-/- or uPA-/-), or in plasminogen activator ..
- Ovulation in plasminogen-deficient miceA Ny
Department of Medical Biosciences, Medical Biochemistry, Umea University, Sweden
Endocrinology 140:5030-5. 1999Many different studies suggest that plasmin generated from plasminogen plays a crucial role in the degradation of the follicular wall at the time of ovulation...
- The development of bleomycin-induced pulmonary fibrosis in mice deficient for components of the fibrinolytic systemC M Swaisgood
Joseph J Jacobs Center for Thrombosis and Vascular Biology and the Department of Molecular Cardiology, Cleveland Clinic Foundation, OH, USA
Am J Pathol 157:177-87. 2000..the effect of bleomycin, an agent that induces the development of pulmonary fibrosis, in mice deficient for plasminogen (Pg(-)(/-)), urokinase (u-PA(-)(/-)), urokinase receptor (u-PAR(-)(/-)), or tissue plasminogen activator (t-PA(-..
- Growth and behavioral development in plasminogen gene-targeted miceJ Hoover-Plow
Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic Foundation, Ohio 44196, USA
Growth Dev Aging 63:13-32. 1999The plasminogen system, in addition to its major role in fibrinolyis, is believed to play a key role in development of the nervous system...
- Lactational competence and involution of the mouse mammary gland require plasminogenL R Lund
Finsen Laboratory, Copenhagen University Hospital, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
Development 127:4481-92. 2000Urokinase-type plasminogen activator expression is induced in the mouse mammary gland during development and post-lactational involution...
- Mice lacking tPA, uPA, or plasminogen genes showed delayed functional recovery after sciatic nerve crushL B Siconolfi
Neuroscience Program and Department of Biochemistry and Molecular Genetics, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
J Neurosci 21:4348-55. 2001..These proteases include the plasminogen activators (PAs), tissue PA (tPA) and urokinase PA (uPA), and their substrate, plasminogen...
- Plasmin-dependent and -independent effects of plasminogen activators and inhibitor-1 on ex vivo angiogenesisS Brodsky
Department of Medicine, State University of New York, Stony Brook, New York 11794 8152, USA
Am J Physiol Heart Circ Physiol 281:H1784-92. 2001b>Plasminogen activator (PA) inhibitor-1 (PAI-1) has been recognized as a surrogate marker of endothelial dysfunction in diseases associated with impaired angiogenesis, including atherosclerosis, diabetic vasculopathy, and nephropathy...
- Plasmin activity is required for myogenesis in vitro and skeletal muscle regeneration in vivoMonica Suelves
Centre d Oncologia Molecular, Institut de Recerca Oncologica, Barcelona, Spain
Blood 99:2835-44. 2002..Active plasmin is generated from proteolytic cleavage of the zymogen plasminogen (Plg) by urokinase-type plasminogen activator (uPA) and tissue-type plasminogen activator (tPA)...
- Collagen dissolution by keratinocytes requires cell surface plasminogen activation and matrix metalloproteinase activitySarah Netzel-Arnett
Matrix Metalloproteinase Unit, NIDCR, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 277:45154-61. 2002..Here we show that keratinocytes use an alternative plasminogen and matrix metalloproteinase-13-dependent pathway for dissolution of collagen fibrils...
- Plasminogen is a critical host pathogenicity factor for group A streptococcal infectionHongmin Sun
Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
Science 305:1283-6. 2004..a common human pathogen, secrete streptokinase, which activates the host's blood clot-dissolving protein, plasminogen. Streptokinase is highly specific for human plasminogen, exhibiting little or no activity against other ..
- A central role for plasminogen in the inflammatory response to biomaterialsS J Busuttil
Case Western Reserve University and Cleveland VAMC, Cleveland, Ohio, USA
J Thromb Haemost 2:1798-805. 2004The inflammatory response to implanted biomaterials severely limits their deployment in patients. Plasminogen has been shown to play a central role in cell migration, and therefore could regulate this inflammatory response...
- Cleavage of proBDNF by tPA/plasmin is essential for long-term hippocampal plasticityPetti T Pang
Section on Neural Development and Plasticity, Laboratory of Cellular and Synaptic Neurophysiology, National Institute of Child Health and Human Development NICHD, Bethesda, MD 20892, USA
Science 306:487-91. 2004..Two secretory proteins, tissue plasminogen activator (tPA) and brain-derived neurotrophic factor (BDNF), have been implicated in this process, but their ..
- MT1-MMP-dependent neovessel formation within the confines of the three-dimensional extracellular matrixTae Hwa Chun
Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
J Cell Biol 167:757-67. 2004..Unexpectedly, neither MMP-2, MMP-9, their cognate cell-surface receptors (i.e., beta3 integrin and CD44), nor plasminogen are essential for collagenolytic activity, endothelial cell invasion, or neovessel formation...
- Plasminogen/plasmin regulates c-fos and egr-1 expression via the MEK/ERK pathwayLirlândia P de Sousa
Grupo de Transdução de Sinal, Departamento de Microbiologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, 31270 901 Belo Horizonte, Minas Gerais, Brazil
Biochem Biophys Res Commun 329:237-45. 2005In this study, we showed that plasminogen (Plg) and plasmin (Pla) bind to lysine-binding sites on cell surface and trigger a signaling pathway that activates the mitogen-activated protein kinase (MAPK) MEK and ERK1/2, which in turn leads ..
- The plasminogen activator/plasmin system is essential for development of the joint inflammatory phase of collagen type II-induced arthritisJinan Li
Department of Medical Biochemistry and Biophysics, Umea University, SE 901 87 Umea, Sweden
Am J Pathol 166:783-92. 2005The plasminogen activator (PA) system has been proposed to have important roles in rheumatoid arthritis...
- Apo(a) promotes thrombosis in a vascular injury model by a mechanism independent of plasminogenJ Sha
Department of Molecular Cardiology, Joseph J Jacobs Center for Thrombosis and Vascular Biology, The Cleveland Clinic Lerner Research Institute, Cleveland, OH 44195, USA
J Thromb Haemost 3:2281-9. 2005Structural similarity between apolipoprotein(a) [apo(a)], the unique apoprotein of lipoprotein(a), and plasminogen (Plg), the zymogen for plasmin, results in inhibition of functions of Plg by apo(a) in vitro...
- Plasminogen activation independent of uPA and tPA maintains wound healing in gene-deficient miceLeif R Lund
Finsen Laboratory, Rigshospitalet, Strandboulevarden 49, Copenhagen, Denmark
EMBO J 25:2686-97. 2006Simultaneous ablation of the two known activators of plasminogen (Plg), urokinase-type (uPA) and the tissue-type (tPA), results in a substantial delay in skin wound healing...
- Profibrinolytic effects of metalloproteinases during skin wound healing in the absence of plasminogenKirsty A Green
Finsen Laboratory, Rigshospitalet, Copenhagen Biocenter, Copenhagen, Denmark
J Invest Dermatol 128:2092-101. 2008Genetic ablation of plasminogen (Plg) and pharmacological inhibition of metalloproteinase activity by galardin delay skin wound healing in mice, whereas the combined inhibition of these two enzyme systems completely prevents healing...
- The plasminogen fibrinolytic pathway is required for hematopoietic regenerationBeate Heissig
Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo, 108 8639, Japan
Cell Stem Cell 1:658-70. 2007..However, little is known about how this stress response is coordinated. Here, we show that plasminogen (Plg), a classical fibrinolytic factor, is a key player in controlling this stress response...
- Inflammatory macrophage migration requires MMP-9 activation by plasminogen in miceYanqing Gong
Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Cardiovascular Medicine, Cleveland Clinic Lerner Research Institute, Cleveland, Ohio 44195, USA
J Clin Invest 118:3012-24. 2008..b>Plasminogen (Plg) is a protease that binds to the ECM and, upon conversion to plasmin, degrades multiple ECM proteins...
- Tissue plasminogen activator promotes axonal outgrowth on CNS myelin after conditioned injuryKenneth Minor
Department of Biochemistry and Molecular Genetics, University of Colorado Denver, School of Medicine, Aurora, Colorado 8004, USA
J Neurochem 109:706-15. 2009..The following study suggests that the proteolytic enzyme tissue plasminogen activator (tPA) plays a major function in 'conditioning-injury induced' axon regeneration...
- Skin wound healing in MMP2-deficient and MMP2 / plasminogen double-deficient miceSigne Frøssing
Finsen Laboratory, Copenhagen University Hospital, Copenhagen Biocenter, Ole Maaløes Vej 5, Copenhagen N, Denmark
Exp Dermatol 19:e234-40. 2010..process depends on the concomitant activity of several extracellular proteases, including members of the plasminogen activation (PA) system and the matrix metalloproteinase (MMP) family...
- Phenotypic overlap between MMP-13 and the plasminogen activation system during wound healing in miceAnna Juncker-Jensen
Finsen Laboratory, Rigshospitalet, Copenhagen Biocenter, Copenhagen, Denmark
PLoS ONE 6:e16954. 2011..Thus, healing of skin wounds is delayed by either plasminogen-deficiency or by treatment with the broad-spectrum metalloproteinase (MP) inhibitor Galardin alone, while the ..
- PAR1 contributes to influenza A virus pathogenicity in miceKhaled Khoufache
Virologie et Pathologie Humaine, EA 4610, Université Lyon1, Faculté de médecine RTH Laennec, Lyon, France
J Clin Invest 123:206-14. 2013..Treatment with the PAR1 agonist did not alter survival of mice deficient in plasminogen (PLG), which suggests that PLG permits and/or interacts with a PAR1 function in this model...
- Plasminogen deficiency accelerates vessel wall disease in mice predisposed to atherosclerosisQ Xiao
Division of Developmental Biology, Children s Hospital Research Foundation, Cincinnati, OH 45229, USA
Proc Natl Acad Sci U S A 94:10335-40. 1997..To directly examine the role of the key fibrinolytic factor, plasminogen, in atherogenesis, plasminogen-deficient mice were crossed to hypercholesterolemic, apolipoprotein E-deficient ..
- Lack of plasminogen leads to milk stasis and premature mammary gland involution during lactationKirsty A Green
Finsen Laboratory, Rigshospitalet, Strandboulevarden 49, DK 2100, Copenhagen, Denmark
Dev Biol 299:164-75. 2006The extracellular serine protease, plasmin, is activated from its precursor, plasminogen (Plg), by the urokinase-type and tissue-type Plg activators (uPA and tPA respectively)...
- Plasminogen is a critical determinant of vascular remodeling in miceA F Drew
Children s Hospital Research Foundation, Cincinnati, OH 45229 3039, USA
Circ Res 87:133-9. 2000..To investigate the role of plasminogen-mediated proteolysis in remodeling, polyethylene cuffs were placed around the femoral arteries of mice with ..
- A functional overlap of plasminogen and MMPs regulates vascularization during placental developmentHelene Solberg
Finsen Laboratory, Rigshospitalet, Strandboulevarden 49, 2100 Copenhagen, Denmark
Development 130:4439-50. 2003Both plasminogen activators and matrix metalloproteinases (MMPs) have been implicated in a variety of developmental processes in the mouse during embryo implantation and placentation...
- Plasmin deficiency does not alter endogenous murine amyloid beta levels in miceH Michael Tucker
Department of Physiology, Sanders Brown Center on Aging, University of Kentucky, 800 S Limestone St, Lexington, KY 40536 0230, USA
Neurosci Lett 368:285-9. 2004..In this study, we sought to determine if plasminogen deficiency increases endogenous A beta...
- Synergy between a plasminogen cascade and MMP-9 in autoimmune diseaseZhi Liu
Department of Dermatology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
J Clin Invest 115:879-87. 2005Extracellular proteolysis by the plasminogen/plasmin (Plg/plasmin) system and MMPs is required for tissue injury in autoimmune and inflammatory diseases...
- Insulin-like growth factor-binding protein-5 activates plasminogen by interaction with tissue plasminogen activator, independently of its ability to bind to plasminogen activator inhibitor-1, insulin-like growth factor-I, or heparinAlice M Sorrell
Hannah Research Institute, Ayr KA6 5HL, United Kingdom
J Biol Chem 281:10883-9. 2006..Because IGFBP-5 has been reported to bind to plasminogen activator inhibitor-1 (PAI-1), we determined the effects of this interaction in HC11 cells...
- Endogenous tissue-type plasminogen activator is protective during Escherichia coli-induced abdominal sepsis in miceRosemarijn Renckens
Center of Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
J Immunol 177:1189-96. 2006Sepsis is associated with enhanced production of tissue-type plasminogen activator (tPA)...
- Proteolytic activation of monocyte chemoattractant protein-1 by plasmin underlies excitotoxic neurodegeneration in miceJohn J Sheehan
Department of Pharmacological Sciences and Program in Molecular and Cellular Pharmacology, Stony Brook University, Stony Brook, New York 11794 8651, USA
J Neurosci 27:1738-45. 2007..We show here that mice genetically deficient for MCP-1 phenocopy plasminogen deficiency by displaying decreased microglial recruitment and resisting excitotoxic neurodegeneration...
- Fibrinogen deficiency, but not plasminogen deficiency, increases mortality synergistically in combination with sickle hemoglobin SAD in transgenic miceNancy J Roszell
Comprehensive Sickle Cell Center, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
Am J Hematol 82:1044-8. 2007..between sickle cell pathology and activation of the hemostatic system, mice with targeted deletions of plasminogen (Plg) or fibrinogen (Fib) were crossed with transgenic mice expressing Hb SAD [beta(6Glu-Val) (HbS), beta(23Val-..
- Plasminogen activator induction facilitates recovery of respiratory function following spinal cord injuryKenneth H Minor
Department of Biochemistry and Molecular Genetics and Neuroscience Program, University of Colorado School of Medicine, UCDHSC, MS 8315, P O Box 6511, Aurora, CO 80045, USA
Mol Cell Neurosci 37:143-52. 2008The possibility that plasminogen activator (PA) plays a role in synaptic plasticity was explored in the spinal cord during the crossed phrenic phenomenon (CPP), where respiratory functional plasticity develops following spinal cord ..
- Histone H3 lysine 36 methyltransferase Hypb/Setd2 is required for embryonic vascular remodelingMing Hu
State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
Proc Natl Acad Sci U S A 107:2956-61. 2010..Taken together, these results indicate that Hypb is required for embryonic vascular remodeling and provide a tool to study the function of H3K36 methylation in vasculogenesis/angiogenesis...
- Tissue plasminogen activator and plasminogen are critical for osmotic homeostasis by regulating vasopressin secretionYuhki Imamura
Department of Applied Biology, Kyoto Institute of Technology, Matsugasaki, Sakyo ku, Kyoto, Japan
J Neurosci Res 88:1995-2006. 2010..In the present study, we demonstrated that the immunoreactivity of tissue plasminogen activator (tPA) was observed specifically at neurosecretory granules of AVP-positive magnocellular terminals ..
- Mouse plasminogen has oxidized phosphatidylcholine adducts that are not metabolized by lipoprotein-associated phospholipase A₂under basal conditionsCelina Edelstein
Department of Medicine, University of Chicago, Chicago, IL 60637, USA E Mails C E D P
Int J Mol Sci 11:5339-47. 2010We previously showed that plasminogen (Plg) isolated from the plasma of normal human subjects contains 1-2 moles of oxidized phosphatidylcholine (oxPtdPC) adducts/mole of protein...
- Regulation of macrophage migration by a novel plasminogen receptor Plg-R KTShahrzad Lighvani
Department of Cell Biology, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
Blood 118:5622-30. 2011..These functions are promoted by plasminogen receptors exposing C-terminal basic residues on the macrophage surface...
- Nucleocytoplasmic coagulation: an injury-induced aggregation event that disulfide crosslinks proteins and facilitates their removal by plasminAndre L Samson
Australian Centre for Blood Diseases, AMREP, Monash University, Melbourne, Victoria 3004, Australia
Cell Rep 2:889-901. 2012..oligomers, also seen in human brain tissue following neurotrauma, act as a cofactor and substrate for the plasminogen-activating system...
- Macrophage gene expression and foam cell formation are regulated by plasminogenRiku Das
Department of Molecular Cardiology, Cleveland Clinic, Cleveland, OH 44195, USA
Circulation 127:1209-18, e1-16. 2013..Deciphering the molecular and cellular processes that govern macrophage foam cell formation is critical to understanding the basic mechanisms underlying atherosclerosis and other vascular pathologies...
- Plasminogen-stimulated inflammatory cytokine production by airway smooth muscle cells is regulated by annexin A2Michael Schuliga
1 Department Pharmacol, University of Melbourne, Parkville, Victoria, Australia
Am J Respir Cell Mol Biol 49:751-8. 2013b>Plasminogen has a role in airway inflammation. Airway smooth muscle (ASM) cells cleave plasminogen into plasmin, a protease with proinflammatory activity...
- Pneumococcal phosphoglycerate kinase interacts with plasminogen and its tissue activatorM Fulde
Simone Bergmann, PhD, Technische Universitat Braunschweig, Spielmannstrasse 7, 38106 Braunschweig, Germany, Tel 49 531 391 5818, Fax 49 531 391 5854, E mail
Thromb Haemost 111:401-16. 2014..is localised on the pneumococcal surface of both capsulated and non-capsulated strains and colocalises with plasminogen. Since pneumococci may concentrate host plasminogen (PLG) together with its activators on the bacterial cell ..
- Staphylococcus aureus manganese transport protein C (MntC) is an extracellular matrix- and plasminogen-binding proteinNatália Salazar
Centro de Ciencias Naturais e Humanas, Universidade Federal do ABCSanto André, Brazil
PLoS ONE 9:e112730. 2014..ECM and coagulation cascade components, including laminin, collagen type IV, cellular and plasma fibronectin, plasminogen and fibrinogen by ELISA...
- The Tissue Fibrinolytic System Contributes to the Induction of Macrophage Function and CCL3 during Bone Repair in MiceNaoyuki Kawao
Department of Physiology and Regenerative Medicine, Kinki University Faculty of Medicine, Osakasayama, Japan
PLoS ONE 10:e0123982. 2015..system to the macrophage functions in bone repair after femoral bone defect by using male mice deficient in plasminogen (Plg-/-), urokinase-type plasminogen activator (uPA-/-) or tissue-type plasminogen activator (tPA-/-) genes and ..
- A CCR2 macrophage endocytic pathway mediates extravascular fibrin clearance in vivoMichael P Motley
Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD
Blood 127:1085-96. 2016..Cellular fibrin uptake was strictly dependent on plasminogen and plasminogen activator...
- Plasmin-dependent proteolysis of tissue factor pathway inhibitor in a mouse model of endotoxemiaC Lupu
Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
J Thromb Haemost 11:142-8. 2013..The mechanism for the decline in TFPI activity in the lung could involve plasmin-mediated cleavage of the inhibitor...
- Plasmin promotes foam cell formation by increasing macrophage catabolism of aggregated low-density lipoproteinAbigail S Haka
Department of Biochemistry, Weill Cornell Medical College, New York, NY 10065, USA
Arterioscler Thromb Vasc Biol 33:1768-78. 2013The plasmin/plasminogen system is involved in atherosclerosis. However, the mechanisms by which it stimulates disease are not fully defined...
- Genetic mapping of three human homologues of murine t-complex genes localizes TCP10 to 6q27, 15 cM distal to TCP1 and PLGH Blanche
Centre d Etude du Polymorphisme Humain CEPH, Paris, France
Genomics 12:826-8. 1992..TCP1, TCP10, and PLG are human homologues of genes located in the proximal portion of the t-complex on mouse chromosome 17...
- Restoration of thrombolytic potential in plasminogen-deficient mice by bolus administration of plasminogenH R Lijnen
Center for Molecular and Vascular Biology, University of Leuven, Belgium
Blood 88:870-6. 1996Homozygous plasminogen-deficient (Plg-/-) mice had a significantly reduced thrombolytic capacity toward intravenously injected 125I-fibrin labeled plasma clots prepared from Plg-/- murine plasma (9% +/- 3% lysis after 8 hours; (mean +/- ..
- Homozygous mutations in the plasminogen gene of two unrelated girls with ligneous conjunctivitisV Schuster
Children s Hospital, University of Wurzburg, Germany
Blood 90:958-66. 1997..Both children exhibited a severe plasminogen deficiency...
- Characterization of the C3 YAC contig from proximal mouse chromosome 17 and analysis of allelic expression of genes flanking the imprinted Igf2r geneN Schweifer
The Netherlands Cancer Institute H5, Amsterdam
Genomics 43:285-97. 1997..The remaining genes in this region have previously been shown to be biallelically expressed...
- Insulin-like growth factor II receptor, transforming growth factor-beta, and Cdk4 expression and the developmental epigenetics of mouse palate morphogenesis and dysmorphogenesisM Melnick
Laboratory for Developmental Genetics, University of Southern California, Los Angeles 90089 0641, USA
Dev Dyn 211:11-25. 1998..we show 1) the presence of insulin-like growth factor II (IGF-II), IGF-II receptor (IGF-IIR), IGF-IR, TGF-beta, plasminogen, plasminogen activators [urokinase plasminogen activator (uPA) and tissue plasminogen activator (tPA)], and ..
- Cloning of the mouse and human solute carrier 22a3 (Slc22a3/SLC22A3) identifies a conserved cluster of three organic cation transporters on mouse chromosome 17 and human 6q26-q27S Verhaagh
Department of Molecular Genetics H5, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, 1066CX, The Netherlands
Genomics 55:209-18. 1999..A BAC contig spanning the mouse Slc22a3 gene was constructed, and Slc22a3 was mapped between the Igf2r and Plg genes in close association with two additional members of the Slc22a gene family, mouse Slc22a1 and Slc22a2...
- Neuronal death and blood-brain barrier breakdown after excitotoxic injury are independent processesZ L Chen
Department of Pharmacology, University at Stony Brook, Stony Brook, New York 11794 8651, USA
J Neurosci 19:9813-20. 1999..To test plasma protein recruitment in neuronal degeneration, we used plasminogen-deficient (plg(-/-)) mice, which are resistant to excitotoxin-induced degeneration...
- Plasminogen-independent initiation of the pro-urokinase activation cascade in vivo. Activation of pro-urokinase by glandular kallikrein (mGK-6) in plasminogen-deficient miceK List
The Finsen Laboratory, Rigshospitalet, Strandboulevarden 49, DK 2100 Copenhagen O, Denmark
Biochemistry 39:508-15. 2000The plasminogen activation (PA) system is involved in the degradation of fibrin and various extracellular matrix proteins, taking part in a number of physiological and pathological tissue remodeling processes including cancer invasion...
- Selective behaviors altered in plasminogen-deficient mice are reconstituted with intracerebroventricular injection of plasminogenJ Hoover-Plow
Department of Molecular Cardiology, Joseph J Jacobs Center for Thrombosis and Vascular Biology, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44196, USA
Brain Res 898:256-64. 2001In vitro studies demonstrate a role for the plasminogen (Plg) system in neurological function and recently in vivo studies show a role of the Plg system in neurodegeneration after the injection of an excitotoxic agent...
- Deficiency of urokinase-type plasminogen activator-mediated plasmin generation impairs vascular remodeling during hypoxia-induced pulmonary hypertension in miceM Levi
Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven, Belgium
Circulation 103:2014-20. 2001Chronic hypoxia results in the development of pulmonary hypertension and subsequent right heart failure. A role of the plasminogen system in the pathogenesis of pulmonary hypertension and pulmonary vascular remodeling has been suggested.
- In vivo regulation of plasminogen function by plasma carboxypeptidase BCarmen M Swaisgood
Department of Molecular Cardiology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
J Clin Invest 110:1275-82. 2002The major functions of plasminogen (Plg) in fibrinolysis and cell migration depend on its binding to carboxy-terminal lysyl residues...
- Plasminogen directs the pleiotropic effects of uPA in liver injury and repairAngela R Currier
Division of Gastroenterology, Hepatology, and Nutrition, Children s Hospital Research Foundation and Department of Pediatrics, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
Am J Physiol Gastrointest Liver Physiol 284:G508-15. 2003The urokinase-type plasminogen activator (uPA) plays a central role in liver repair. Nevertheless, the hepatic overexpression of uPA results in panlobular injury and neonatal mortality...
- Tissue plasminogen activator in the amygdala is critical for stress-induced anxiety-like behaviorRobert Pawlak
Laboratory of Neurobiology and Genetics, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
Nat Neurosci 6:168-74. 2003..Here we found that the serine protease tissue-plasminogen activator (tPA) was upregulated in the central and medial amygdala by acute restraint stress, where it promoted ..
- Mice without uPA, tPA, or plasminogen genes are resistant to experimental choroidal neovascularizationJean Marie Rakic
Department of Ophthalmology, University Hospital, Sart Tilman, Liege, Belgium
Invest Ophthalmol Vis Sci 44:1732-9. 2003To evaluate the presence and potential involvement of members of the plasminogen/plasminogen activator (Plg/PA) system in the exudative form of age-related macular degeneration (AMD).
- Ethanol-withdrawal seizures are controlled by tissue plasminogen activator via modulation of NR2B-containing NMDA receptorsRobert Pawlak
Laboratory of Neurobiology and Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
Proc Natl Acad Sci U S A 102:443-8. 2005..Here we show that tissue-plasminogen activator (tPA), a protease implicated in neuronal plasticity and seizures, is induced in the limbic system by ..
- The effects of intrinsic pathway protease deficiencies on plasminogen-deficient miceQiufang Cheng
Hematology Oncology Division, Department of Pathology, Vanderbilt University, 777 MRB II, 2220 Pierce Ave, Nashville, TN 37232 6307, USA
Blood 106:3055-7. 2005b>Plasminogen (Plg)-deficient mice experience wasting and have decreased longevity due to disseminated fibrin deposition...
- Potentiation of TLR4 signalling by plasmin activityJon R Ward
Division of Genomic Medicine, University of Sheffield Medical School, University of Sheffield, Sheffield S10 2JF, UK
Biochem Biophys Res Commun 341:299-303. 2006..These studies link fibrinolysis and TLR signalling, identifying further mechanisms potentially involved in activation of innate immunity...
- Spontaneous development of otitis media in plasminogen-deficient micePer Olof Eriksson
Department of Clinical Sciences, Otorhinolaryngology, Umea University, SE 901 85 Umea, Sweden
Int J Med Microbiol 296:501-9. 2006..In this study, the role of the plasminogen (plg)/plasmin system for the spontaneous development of chronic otitis media was investigated by the analysis ..
- Genetic background determines response to hemostasis and thrombosisJane Hoover-Plow
Department of Cardiovascular Medicine, Joseph J Jacobs Center for Thrombosis and Vascular Biology, Ohio, USA
BMC Blood Disord 6:6. 2006..The objective of this study was to evaluate thrombosis and hemostasis in these two inbred strains and determine the phenotypic response of A/J chromosomes in the C57BL/6J background...
- Reduction of experimental diabetic vascular leakage by delivery of angiostatin with a recombinant adeno-associated virus vectorMong Ping Shyong
Institute of Clinical Medicine, National Yang Ming University, Taipei and Su Ao Veterans Hospital, I Lan, Taiwan
Mol Vis 13:133-41. 2007To evaluate the efficacy of recombinant adeno-associated virus (rAAV) vector expressing mouse angiostatin (Kringle domains 1 to 4) in reducing retinal vascular leakage in an experimental diabetic rat model.
- Regulation of hepatic stellate cell differentiation by the neurotrophin receptor p75NTRMelissa A Passino
Department of Pharmacology, University of California, San Diego UCSD, La Jolla, CA 92093 0636, USA
Science 315:1853-6. 2007..Our results identify signaling from p75NTR to Rho as a mechanism for the regulation of HSC differentiation to regeneration-promoting cells that support hepatocyte proliferation in the diseased liver...
- Histone H2B as a functionally important plasminogen receptor on macrophagesRiku Das
Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Cleveland Clinic, OH, USA
Blood 110:3763-72. 2007b>Plasminogen (Plg) facilitates inflammatory cell recruitment, a function that depends upon its binding to Plg receptors (Plg-Rs). However, the Plg-Rs that are critical for cell migration are not well defined...
- Tissue-type plasminogen activator and the low-density lipoprotein receptor-related protein mediate cerebral ischemia-induced nuclear factor-kappaB pathway activationXiaohui Zhang
Department of Neurology and Center for Neurodegenerative Disease, Emory University School of Medicine, Whitehead Biomedical Research Bldg, 615 Michael St, Suite 505J, Atlanta, GA 30322, USA
Am J Pathol 171:1281-90. 2007Tissue-type plasminogen activator (tPA) is a serine proteinase found in the intravascular space and the central nervous system...
- Protective role of thrombin activatable fibrinolysis inhibitor in obstructive nephropathy-associated tubulointerstitial fibrosisN E Bruno
Department of Diabetes and Endocrinology, Mie University Graduate School of Medicine, Tsu City, Mie, Japan
J Thromb Haemost 6:139-46. 2008..Thrombin-activatable fibrinolysis inhibitor (TAFI) has been reported to affect wound healing and fibrotic processes, but its role in renal tubulointerstitial fibrosis remains unknown...
- Tissue-type plasminogen activator and the low-density lipoprotein receptor-related protein induce Akt phosphorylation in the ischemic brainJie An
Institute of Pharmacology, Shandong University School of Medicine, Jinan, China
Blood 112:2787-94. 2008Tissue-type plasminogen activator (tPA) is found in the intravascular space and in the central nervous system. The low-density lipoprotein receptor-related protein (LRP) is expressed in neurons and in perivascular astrocytes...
- Plasmin-mediated processing of protein tyrosine phosphatase receptor type Z in the mouse brainJeremy Pak Hong Chow
Division of Molecular Neurobiology, National Institute for Basic Biology, 5 1 Higashiyama, Myodaiji cho, Okazaki, Aichi 444 8787, Japan
Neurosci Lett 442:208-12. 2008....
- Binding of plasminogen to hepatocytes isolated from injured mouse liver and nonparenchymal-cell-dependent proliferation of hepatocytesKiyotaka Okada
Department of Physiology, Kinki University School of Medicine, Osaka, Japan
Blood Coagul Fibrinolysis 19:503-11. 2008..in alpha2-antiplasmin gene knockout mice as compared to wild-type mice, but it was significantly decreased in plasminogen knockout mice, or Plg/alpha2-antiplasmin gene knockout mice...
- A physiological function for apolipoprotein(a): a natural regulator of the inflammatory responseJane Hoover-Plow
Department of Molecular Cardiology, NB50, Cleveland Clinic Lerner Research Institute, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Exp Biol Med (Maywood) 234:28-34. 2009Structural similarities between apolipoprotein(a) (apo(a)), the unique apoprotein of lipoprotein(a), and plasminogen, the zymogen of plasmin, can interfere with functions of plasmin (ogen) in vitro...
- Angiostatin regulates the expression of antiangiogenic and proapoptotic pathways via targeted inhibition of mitochondrial proteinsTong Young Lee
Department of Surgery, Children s Hospital Boston and Harvard Medical School, MA, USA
Blood 114:1987-98. 2009b>Angiostatin, a proteolytic fragment of plasminogen, is a potent endogenous antiangiogenic agent. The molecular mechanisms governing angiostatin's antiangiogenic and antitumor effects are not well understood...
- Feedback regulation of endothelial cell surface plasmin generation by PKC-dependent phosphorylation of annexin A2Kai Li He
Department of Cell and Developmental Biology, Weill Cornell Medical College, New York, New York 10065, USA
J Biol Chem 286:15428-39. 2011..Annexin A2 (A2) heterotetramer (A2·p11)(2) is a key profibrinolytic complex that assembles plasminogen and tissue plasminogen activator and promotes plasmin generation...
- Localization of plasminogen in mouse hippocampus, cerebral cortex, and hypothalamusYuki Taniguchi
Department of Applied Biology, Kyoto Institute of Technology, Matsugasaki, Sakyo ku, Kyoto, 606 8585, Japan
Cell Tissue Res 343:303-17. 2011Although the tissue plasminogen activator/plasminogen system contributes to numerous brain functions, such as learning, memory, and anxiety behavior, little attention has as yet been given to the localization of plasminogen in the brain...
- The mouse plasminogen locus maps to the recombination breakpoints of the tLub2 and TtOrl partial t haplotypes but is not at the tw73 locusN Schweifer
Research Institute of Molecular Pathology, Vienna, Austria
Mamm Genome 2:260-8. 1992The mouse plasminogen (Plg) locus maps to a region of chromosome (Chr) 17 which is inverted in the t haplotype Chromosomal variant...
- Plasminogen Tochigi: inactive plasmin resulting from replacement of alanine-600 by threonine in the active siteT Miyata
Proc Natl Acad Sci U S A 79:6132-6. 1982Structural studies on a hereditarily abnormal plasminogen, plasminogen Tochigi, have been performed to identify the difference responsible for its lack of proteolytic activity...
- High-resolution comparative mapping of mouse chromosome 17H Himmelbauer
Department of Molecular Biology, Princeton University, New Jersey 08544 1014
Genomics 17:110-20. 1993..We present the localization of four new DNA markers and determined map positions for 10 other loci, which previously had been assigned to intervals of the t complex only through the study of partial t haplotype chromosomes...
- Growth and dissemination of Lewis lung carcinoma in plasminogen-deficient miceT H Bugge
Divisions of Developmental Biology and Pathology, Children s Hospital Research Foundation, Cincinnati, OH, USA
Blood 90:4522-31. 1997b>Plasminogen activation has been proposed to play a critical role in cancer invasion and metastasis...
- Reduced metastasis of Polyoma virus middle T antigen-induced mammary cancer in plasminogen-deficient miceT H Bugge
Division of Developmental Biology, Children s Hospital Research Foundation, Cincinnati, Ohio 45229, USA
Oncogene 16:3097-104. 1998To investigate the role of plasmin(ogen) in mammary tumor development and progression, plasminogen-deficient mice were crossed with transgenic mice expressing Polyoma middle T antigen under the control of the mouse mammary tumor virus ..
- Bidirectional action of the Igf2r imprint control element on upstream and downstream imprinted genesR Zwart
Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
Genes Dev 15:2361-6. 2001..These results identify a new cluster of imprinted genes whose repression by the bidirectional action of the Region2-ICE is independent of transcript overlap by the Air RNA...
- SYSTEMATIC EVALUATION OF THE PLASMINOGEN SYSTEMJane Hoover Plow; Fiscal Year: 2003..of the influential variables implicated in both human and mouse models of atherosclerosis and of obesity is the plasminogen system...
- The Mechanism of IVIG Action in PemphigusZhi Liu; Fiscal Year: 2006..The overall goal of this project is to study the mechanisms of WIG action in autoantibody-mediated diseases and develop novel therapies to replace current immunosuppressive treatments, which confer severe side effects. ..
- Mechanisms of cardiac fibrosisApril Stempien Otero; Fiscal Year: 2006..Recent work in the Dichek lab has indicated a possible role for urokinase plasminogen activator(uPA) in cardiac fibrosis...
- Genetic Determinants of A. Fumigatus SusceptibilityAimee Zaas; Fiscal Year: 2008..fumigatus infection, this proposal will identify and characterize genetic polymorphisms related to IA susceptibility in mice and validate these findings in a cohort of human bone marrow transplant donors and recipients. ..